Research Topics
| Ottmar JanssenSummaryAffiliation: University of Kiel Country: Germany Publications
| Collaborators
|
Detail Information
Publications
Signal transduction in the footsteps of goethe and schillerKarlheinz Friedrich
Institute of Biochemistry, University of Jena Medical School, Jena, Germany
Cell Commun Signal 7:2. 2009..This report is intended to share with the readers of CCS some highlights of the Meeting Workshops devoted to specific aspects of signal transduction...- Posttranslational regulation of Fas ligand functionMatthias Voss
Molecular Immunology, Institute of Immunology, Medical Center Schleswig Holstein Campus Kiel, Arnold Heller Str, 3, Bldg, 17, D 24105 Kiel, Germany
Cell Commun Signal 6:11. 2008..Since FasL is regarded as a potential target for immunotherapy, the further characterisation of its biological regulation and function will be of great importance for the development and evaluation of future therapeutic strategies... 
CD95 ligand--death factor and costimulatory molecule?O Janssen
Institute for Immunology, Medical Center Schleswig Holstein, Campus Kiel, Michaelisstrasse 5, D 24105 Kiel, Germany
Cell Death Differ 10:1215-25. 2003....- Effector granules in human T lymphocytes: the luminal proteome of secretory lysosomes from human T cellsHendrik Schmidt
Institute of Immunology, Christian Albrechts University, UK S H Campus Kiel, Kiel, Germany
Cell Commun Signal 9:4. 2011..abstract:.. - The adapter protein Nck: role of individual SH3 and SH2 binding modules for protein interactions in T lymphocytesMarcus Lettau
Molecular Immunology, Institute for Immunology, Christian Albrechts University, D 24105 Kiel, Germany
Protein Sci 19:658-69. 2010..Our data highlight the fundamental role of Nck in the TCR-to-cytoskeleton crosstalk and point to yet unknown nuclear functions of Nck also in T lymphocytes... 
Effector granules in human T lymphocytes: proteomic evidence for two distinct species of cytotoxic effector vesiclesHendrik Schmidt
Institute of Immunology, Christian Albrechts University, Kiel, Germany
J Proteome Res 10:1603-20. 2011..To our knowledge, this is the first comprehensive description of distinct effector granules in T cells...- Identification of interaction partners for individual SH3 domains of Fas ligand associated members of the PCH protein family in T lymphocytesAndreas Linkermann
Institute for Immunology, University Hospital Schleswig Holstein Campus Kiel, Michaelisstr 5, D 24105 Kiel, Germany
Biochim Biophys Acta 1794:168-76. 2009.... - 2-D DIGE analyses of enriched secretory lysosomes reveal heterogeneous profiles of functionally relevant proteins in leukemic and activated human NK cellsHendrik Schmidt
Institute of Immunology, University Hospital Schleswig Holstein Campus Kiel, Kiel, Germany
Proteomics 8:2911-25. 2008.... - The adaptor protein Nck interacts with Fas ligand: Guiding the death factor to the cytotoxic immunological synapseMarcus Lettau
Institute for Immunology, University Hospital Schleswig Holstein Campus Kiel, 24105 Kiel, Germany
Proc Natl Acad Sci U S A 103:5911-6. 2006..Our observations support the previous notion that the unique cytoplasmic tail of FasL is crucial for its directed transport to the cell surface and into the assembling cytotoxic IS... - Enrichment and analysis of secretory lysosomes from lymphocyte populationsHendrik Schmidt
Molecular Immunology, Institute of Immunology, University Hospital Schleswig Holstein Campus Kiel, Kiel, Germany
BMC Immunol 10:41. 2009..In order to analyze the function and content of secretory lysosomes in different cell populations, an efficient enrichment of these organelles is mandatory... - FasL cross-linking inhibits activation of human peripheral T cellsMaren Paulsen
Institute of Immunology, University Hospital Schleswig Holstein Campus Kiel, Arnold Heller Strasse 3, Building 17, D 24105 Kiel, Germany
Int Immunol 21:587-98. 2009.... - Detection and structural characterization of natural Ara h 7, the third peanut allergen of the 2S albumin familyHendrik Schmidt
Molecular Immunology, Institute for Immunology, Christian Albrechts University of Kiel, Building 17, Arnold Heller Strasse 3, D 24105 Kiel, Germany
J Proteome Res 9:3701-9. 2010..0101. Moreover, a putative cleavage site in the Ara h 7.0202 isoform points to the characteristic biological function of conglutins as amylase/trypsin inhibitors... - Regulation of FasL expression: a SH3 domain containing protein family involved in the lysosomal association of FasLJing Qian
Institute of Immunology, University Hospital Schleswig Holstein Campus Kiel, Michaelisstr 5, D 24105 Kiel, Germany
Cell Signal 18:1327-37. 2006.... - Secretory lysosomes and their cargo in T and NK cellsMarcus Lettau
Institute of Immunology, Medical Center Schleswig Holstein Campus Kiel, Michaelisstr 5, D 24105 Kiel, Germany
Immunol Lett 108:10-9. 2007.... - Characterization of Phleum pratense pollen extracts by 2-D DIGE and allergen immunoreactivityHendrik Schmidt
Molecular Immunology, Institute for Immunology, Christian Albrechts University of Kiel, Kiel, Germany
Proteomics 10:4352-62. 2010..As a consequence, it is suggested that the observed differences should be taken into consideration aiming for a standardized diagnosis and therapy of grass pollen allergies as recommended by international medical agencies... - Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screeningMatthias Voss
Institute of Immunology, Christian Albrechts University of Kiel, D 24105 Kiel, Germany
BMC Immunol 10:53. 2009..So far, protein-protein interactions that specifically regulate the fate of the intracellular fragments have not been identified... - Storage, expression and function of Fas ligand, the key death factor of immune cellsMarcus Lettau
Institute of Immunology, University Hospital Schleswig Holstein Campus Kiel, Michaelisstr 5, D 24105 Kiel, Germany
Curr Med Chem 15:1684-96. 2008..This knowledge should allow to improve Fas/FasL-based therapeutical approaches that are currently under development... - Considering Fas ligand as a target for therapyAndreas Linkermann
Medical Center Schleswig-Holstein Campus Kiel, Institute of Immunology, Michaelisstr. 5, D-24105 Kiel, Germany
Expert Opin Ther Targets 9:119-34. 2005..This review summarises the current facts and ideas about the clinical and pharmacological potential of FasL and sFasL as targets for therapeutic interventions... - 2-D DIGE analysis of the proteome of extracts from peanut variants reveals striking differences in major allergen contentsHendrik Schmidt
Laboratory for Molecular Immunology, Institute for Immunology, University Hospital Schleswig Holstein Campus Kiel, Kiel, Germany
Proteomics 9:3507-21. 2009.... - Insights into the molecular regulation of FasL (CD178) biologyMarcus Lettau
Christian Albrechts University, Institute of Immunology, D 24105 Kiel, Germany
Eur J Cell Biol 90:456-66. 2011..This review summarizes the work in the framework of the Collaborative Research Consortium 415 (CRC 415) and provides facts and hypotheses about FasL-interacting proteins and their potential role in FasL biology... - Regulation of activation-induced cell death of mature T-lymphocyte populationsO Janssen
Institute for Immunology, Christian Albrechts University, Kiel, Germany
Cell Tissue Res 301:85-99. 2000.... - Differential regulation of activation-induced cell death in individual human T cell clonesO Janssen
Institute for Immunology, Christian Albrechts University, Kiel, Germany
Int Arch Allergy Immunol 121:183-93. 2000..We and others demonstrated that AICD resistance is associated with a reduced surface expression of CD95L upon restimulation... - Cationic detergents enable the separation of membrane proteins of Plasmodium falciparum-infected erythrocytes by 2D gel electrophoresisStephan Philipp
Department of Zoophysiology, Zoological Institute, University of Kiel, Kiel, Germany
Electrophoresis 33:1120-8. 2012..By using the alternative 2D approach, characteristic host cell membrane proteins and, more importantly, membrane-associated and exported plasmodial proteins were identified that might play a role in parasite-induced host cell modulation... - Identification of interaction partners of the cytosolic polyproline region of CD95 ligand (CD178)Markus Philipp Ghadimi
Institute of Immunology, University Hospital Kiel, Michaelisstr 5, Kiel, Germany
FEBS Lett 519:50-8. 2002..Protein-protein interactions are mediated via Src homology 3 (SH3) domain binding to the polyproline region of CD95L and can be abolished by mutation or deletion of the respective SH3 domain... - Signal transduction, receptors, mediators and genes: younger than ever - the 13th meeting of the Signal Transduction Society focused on aging and immunologyFrank Entschladen
Institute of Immunology, Witten Herdecke University, Germany
Cell Commun Signal 8:2. 2010..This report gives an overview of the presentations of the conference... - Death receptors and caspases: role in lymphocyte proliferation, cell death, and autoimmunitySabine Adam-Klages
Institut fur Immunologie, Universitätsklinikum Schleswig Holstein Campus Kiel, Kiel, Germany
Immunol Res 33:149-66. 2005.... - Signal transduction--receptors, mediators, and genesFrank Entschladen
Institute of Immunology, Witten Herdecke University, Witten, Germany
Sci Signal 2:mr3. 2009..This international and interdisciplinary scientific gathering induced lively discussions and close interactions between participants... - Slowly getting a clue on CD95 ligand biologyAndreas Linkermann
Institute for Immunology, Medical Center Schleswig-Holstein, Campus Kiel, Michaelisstr. 5, D-24105 Kiel, Germany
Biochem Pharmacol 66:1417-26. 2003.... - FasL expression and reverse signallingM Lettau
Institute of Immunology, University Hospital Schleswig Holstein Campus Kiel, Michaelisstr 5, D 24105 Kiel, Germany
Results Probl Cell Differ 49:49-61. 2009.... - ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell deathM Schulte
Biochemical Institute, Christian Albrecht University, Kiel, Germany
Cell Death Differ 14:1040-9. 2007..Overall, our findings suggest that ADAM10 represents an important molecular modulator of FasL-mediated cell death... - Pro- and anti-apoptotic CD95 signaling in T cellsMaren Paulsen
Christian Albrechts University of Kiel Institute of Immunology, University Hospital Schleswig Holstein Campus Kiel, Arnold Heller Str, 3 Bldg 17, D 24105 Kiel, Germany
Cell Commun Signal 9:7. 2011.... - Nck adapter proteins: functional versatility in T cellsMarcus Lettau
University Hospital Schleswig Holstein Campus Kiel, Institute of Immunology, Molecular Immunology, Arnold Heller Str 3, Bldg 17, D 24105 Kiel, Germany
Cell Commun Signal 7:1. 2009..g. in the control of gene expression and proliferation... - The responsiveness of human V delta 1 gamma delta T cells to Borrelia burgdorferi is largely restricted to synovial-fluid cells from patients with Lyme arthritisAndrea Glatzel
Institute of Immunology, University of Kiel, Kiel, Germany
J Infect Dis 186:1043-6. 2002..Thus, the responsiveness to Borrelia antigens is not a general property of V delta 1-expressing gamma delta T cells but is largely restricted to V delta 1 gamma delta T cells recruited into the inflamed tissue... - Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factorJ Wenzel
Institute for Immunology, Christian Albrechts University, Michaelisstrasse 5, 24105 Kiel, Germany
FEBS Lett 509:255-62. 2001..These results may help to explain the costimulatory capacity of CD95L... - Regulation of T-cell death-associated gene 51 (TDAG51) expression in human T-cellsH H Oberg
Institute of Immunology, University Hospital Schleswig Holstein Campus Kiel, Kiel, Germany
Cell Death Differ 11:674-84. 2004..Our results indicate that the expression of TDAG51 in human T-cells does not correlate with AICD...