Ottmar Janssen

Summary

Affiliation: University of Kiel
Country: Germany

Publications

  1. pmc Meeting report: Signal transduction meets systems biology
    Christine Louis-Dit-Sully
    Max Planck Institute of Immunobiology and Epigenetics and Biology III, Faculty of Biology, University of Freiburg, 79108, Freiburg, Germany
    Cell Commun Signal 10:11. 2012
  2. pmc Down-regulation of the cancer/testis antigen 45 (CT45) is associated with altered tumor cell morphology, adhesion and migration
    Anja Koop
    Institute for Immunology, University Hospital Schleswig Holstein Campus Kiel, Arnold Heller Str, 3, Bldg 17, Kiel, 24105, Germany
    Cell Commun Signal 11:41. 2013
  3. pmc Signal transduction in the footsteps of goethe and schiller
    Karlheinz Friedrich
    Institute of Biochemistry, University of Jena Medical School, Jena, Germany
    Cell Commun Signal 7:2. 2009
  4. ncbi request reprint CD95 ligand--death factor and costimulatory molecule?
    O Janssen
    Institute for Immunology, Medical Center Schleswig Holstein, Campus Kiel, Michaelisstrasse 5, D 24105 Kiel, Germany
    Cell Death Differ 10:1215-25. 2003
  5. pmc Effector granules in human T lymphocytes: the luminal proteome of secretory lysosomes from human T cells
    Hendrik Schmidt
    Institute of Immunology, Christian Albrechts University, UK S H Campus Kiel, Kiel, Germany
    Cell Commun Signal 9:4. 2011
  6. pmc Posttranslational regulation of Fas ligand function
    Matthias Voss
    Molecular Immunology, Institute of Immunology, Medical Center Schleswig Holstein Campus Kiel, Arnold Heller Str, 3, Bldg, 17, D 24105 Kiel, Germany
    Cell Commun Signal 6:11. 2008
  7. pmc The adapter protein Nck: role of individual SH3 and SH2 binding modules for protein interactions in T lymphocytes
    Marcus Lettau
    Molecular Immunology, Institute for Immunology, Christian Albrechts University, D 24105 Kiel, Germany
    Protein Sci 19:658-69. 2010
  8. ncbi request reprint Regulation of FasL expression: a SH3 domain containing protein family involved in the lysosomal association of FasL
    Jing Qian
    Institute of Immunology, University Hospital Schleswig Holstein Campus Kiel, Michaelisstr 5, D 24105 Kiel, Germany
    Cell Signal 18:1327-37. 2006
  9. pmc The adaptor protein Nck interacts with Fas ligand: Guiding the death factor to the cytotoxic immunological synapse
    Marcus Lettau
    Institute for Immunology, University Hospital Schleswig Holstein Campus Kiel, 24105 Kiel, Germany
    Proc Natl Acad Sci U S A 103:5911-6. 2006
  10. doi request reprint Effector granules in human T lymphocytes: proteomic evidence for two distinct species of cytotoxic effector vesicles
    Hendrik Schmidt
    Institute of Immunology, Christian Albrechts University, Kiel, Germany
    J Proteome Res 10:1603-20. 2011

Collaborators

Detail Information

Publications41

  1. pmc Meeting report: Signal transduction meets systems biology
    Christine Louis-Dit-Sully
    Max Planck Institute of Immunobiology and Epigenetics and Biology III, Faculty of Biology, University of Freiburg, 79108, Freiburg, Germany
    Cell Commun Signal 10:11. 2012
    ..Here we report on a selection of ongoing projects of SYBILLA and how they were discussed at this interdisciplinary conference...
  2. pmc Down-regulation of the cancer/testis antigen 45 (CT45) is associated with altered tumor cell morphology, adhesion and migration
    Anja Koop
    Institute for Immunology, University Hospital Schleswig Holstein Campus Kiel, Arnold Heller Str, 3, Bldg 17, Kiel, 24105, Germany
    Cell Commun Signal 11:41. 2013
    ..As for many CT antigens, the biological function of CT45 in developing germ cells and in tumor cells is largely unknown...
  3. pmc Signal transduction in the footsteps of goethe and schiller
    Karlheinz Friedrich
    Institute of Biochemistry, University of Jena Medical School, Jena, Germany
    Cell Commun Signal 7:2. 2009
    ..This report is intended to share with the readers of CCS some highlights of the Meeting Workshops devoted to specific aspects of signal transduction...
  4. ncbi request reprint CD95 ligand--death factor and costimulatory molecule?
    O Janssen
    Institute for Immunology, Medical Center Schleswig Holstein, Campus Kiel, Michaelisstrasse 5, D 24105 Kiel, Germany
    Cell Death Differ 10:1215-25. 2003
    ....
  5. pmc Effector granules in human T lymphocytes: the luminal proteome of secretory lysosomes from human T cells
    Hendrik Schmidt
    Institute of Immunology, Christian Albrechts University, UK S H Campus Kiel, Kiel, Germany
    Cell Commun Signal 9:4. 2011
    ..abstract:..
  6. pmc Posttranslational regulation of Fas ligand function
    Matthias Voss
    Molecular Immunology, Institute of Immunology, Medical Center Schleswig Holstein Campus Kiel, Arnold Heller Str, 3, Bldg, 17, D 24105 Kiel, Germany
    Cell Commun Signal 6:11. 2008
    ..Since FasL is regarded as a potential target for immunotherapy, the further characterisation of its biological regulation and function will be of great importance for the development and evaluation of future therapeutic strategies...
  7. pmc The adapter protein Nck: role of individual SH3 and SH2 binding modules for protein interactions in T lymphocytes
    Marcus Lettau
    Molecular Immunology, Institute for Immunology, Christian Albrechts University, D 24105 Kiel, Germany
    Protein Sci 19:658-69. 2010
    ..Our data highlight the fundamental role of Nck in the TCR-to-cytoskeleton crosstalk and point to yet unknown nuclear functions of Nck also in T lymphocytes...
  8. ncbi request reprint Regulation of FasL expression: a SH3 domain containing protein family involved in the lysosomal association of FasL
    Jing Qian
    Institute of Immunology, University Hospital Schleswig Holstein Campus Kiel, Michaelisstr 5, D 24105 Kiel, Germany
    Cell Signal 18:1327-37. 2006
    ....
  9. pmc The adaptor protein Nck interacts with Fas ligand: Guiding the death factor to the cytotoxic immunological synapse
    Marcus Lettau
    Institute for Immunology, University Hospital Schleswig Holstein Campus Kiel, 24105 Kiel, Germany
    Proc Natl Acad Sci U S A 103:5911-6. 2006
    ..Our observations support the previous notion that the unique cytoplasmic tail of FasL is crucial for its directed transport to the cell surface and into the assembling cytotoxic IS...
  10. doi request reprint Effector granules in human T lymphocytes: proteomic evidence for two distinct species of cytotoxic effector vesicles
    Hendrik Schmidt
    Institute of Immunology, Christian Albrechts University, Kiel, Germany
    J Proteome Res 10:1603-20. 2011
    ..To our knowledge, this is the first comprehensive description of distinct effector granules in T cells...
  11. doi request reprint Identification of interaction partners for individual SH3 domains of Fas ligand associated members of the PCH protein family in T lymphocytes
    Andreas Linkermann
    Institute for Immunology, University Hospital Schleswig Holstein Campus Kiel, Michaelisstr 5, D 24105 Kiel, Germany
    Biochim Biophys Acta 1794:168-76. 2009
    ....
  12. doi request reprint 2-D DIGE analyses of enriched secretory lysosomes reveal heterogeneous profiles of functionally relevant proteins in leukemic and activated human NK cells
    Hendrik Schmidt
    Institute of Immunology, University Hospital Schleswig Holstein Campus Kiel, Kiel, Germany
    Proteomics 8:2911-25. 2008
    ....
  13. doi request reprint FasL cross-linking inhibits activation of human peripheral T cells
    Maren Paulsen
    Institute of Immunology, University Hospital Schleswig Holstein Campus Kiel, Arnold Heller Strasse 3, Building 17, D 24105 Kiel, Germany
    Int Immunol 21:587-98. 2009
    ....
  14. pmc Enrichment and analysis of secretory lysosomes from lymphocyte populations
    Hendrik Schmidt
    Molecular Immunology, Institute of Immunology, University Hospital Schleswig Holstein Campus Kiel, Kiel, Germany
    BMC Immunol 10:41. 2009
    ..In order to analyze the function and content of secretory lysosomes in different cell populations, an efficient enrichment of these organelles is mandatory...
  15. doi request reprint Detection and structural characterization of natural Ara h 7, the third peanut allergen of the 2S albumin family
    Hendrik Schmidt
    Molecular Immunology, Institute for Immunology, Christian Albrechts University of Kiel, Building 17, Arnold Heller Strasse 3, D 24105 Kiel, Germany
    J Proteome Res 9:3701-9. 2010
    ..0101. Moreover, a putative cleavage site in the Ara h 7.0202 isoform points to the characteristic biological function of conglutins as amylase/trypsin inhibitors...
  16. ncbi request reprint Secretory lysosomes and their cargo in T and NK cells
    Marcus Lettau
    Institute of Immunology, Medical Center Schleswig Holstein Campus Kiel, Michaelisstr 5, D 24105 Kiel, Germany
    Immunol Lett 108:10-9. 2007
    ....
  17. pmc Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening
    Matthias Voss
    Institute of Immunology, Christian Albrechts University of Kiel, D 24105 Kiel, Germany
    BMC Immunol 10:53. 2009
    ..So far, protein-protein interactions that specifically regulate the fate of the intracellular fragments have not been identified...
  18. doi request reprint Characterization of Phleum pratense pollen extracts by 2-D DIGE and allergen immunoreactivity
    Hendrik Schmidt
    Molecular Immunology, Institute for Immunology, Christian Albrechts University of Kiel, Kiel, Germany
    Proteomics 10:4352-62. 2010
    ..As a consequence, it is suggested that the observed differences should be taken into consideration aiming for a standardized diagnosis and therapy of grass pollen allergies as recommended by international medical agencies...
  19. ncbi request reprint Slowly getting a clue on CD95 ligand biology
    Andreas Linkermann
    Institute for Immunology, Medical Center Schleswig Holstein, Campus Kiel, Michaelisstr 5, D 24105 Kiel, Germany
    Biochem Pharmacol 66:1417-26. 2003
    ....
  20. ncbi request reprint Considering Fas ligand as a target for therapy
    Andreas Linkermann
    Medical Center Schleswig Holstein Campus Kiel, Institute of Immunology, Michaelisstr 5, D 24105 Kiel, Germany
    Expert Opin Ther Targets 9:119-34. 2005
    ..This review summarises the current facts and ideas about the clinical and pharmacological potential of FasL and sFasL as targets for therapeutic interventions...
  21. ncbi request reprint Storage, expression and function of Fas ligand, the key death factor of immune cells
    Marcus Lettau
    Institute of Immunology, University Hospital Schleswig Holstein Campus Kiel, Michaelisstr 5, D 24105 Kiel, Germany
    Curr Med Chem 15:1684-96. 2008
    ..This knowledge should allow to improve Fas/FasL-based therapeutical approaches that are currently under development...
  22. doi request reprint Shedding of endogenous MHC class I-related chain molecules A and B from different human tumor entities: heterogeneous involvement of the "a disintegrin and metalloproteases" 10 and 17
    Guranda Chitadze
    Institute of Immunology, Christian Albrechts University Kiel, Kiel, Germany
    Int J Cancer 133:1557-66. 2013
    ..These data indicate that the release of NKG2D ligands from individual tumor entities is by far more complex than suggested in previously reported MICA/B transfection systems. ..
  23. doi request reprint Differential protein-protein interactions of full length human FasL and FasL fragments generated by proteolysis
    Marcus Lettau
    Institute of Immunology, University Hospital Schleswig Holstein, Campus Kiel, Arnold Heller Str 3, Building 17, D 24105 Kiel, Germany Electronic address
    Exp Cell Res 320:290-301. 2014
    ..The differential binding most likely governs the fate and function of the intracellular FasL fragments. ..
  24. ncbi request reprint The responsiveness of human V delta 1 gamma delta T cells to Borrelia burgdorferi is largely restricted to synovial-fluid cells from patients with Lyme arthritis
    Andrea Glatzel
    Institute of Immunology, University of Kiel, Kiel, Germany
    J Infect Dis 186:1043-6. 2002
    ..Thus, the responsiveness to Borrelia antigens is not a general property of V delta 1-expressing gamma delta T cells but is largely restricted to V delta 1 gamma delta T cells recruited into the inflamed tissue...
  25. doi request reprint 2-D DIGE analysis of the proteome of extracts from peanut variants reveals striking differences in major allergen contents
    Hendrik Schmidt
    Laboratory for Molecular Immunology, Institute for Immunology, University Hospital Schleswig Holstein Campus Kiel, Kiel, Germany
    Proteomics 9:3507-21. 2009
    ....
  26. doi request reprint Insights into the molecular regulation of FasL (CD178) biology
    Marcus Lettau
    Christian Albrechts University, Institute of Immunology, D 24105 Kiel, Germany
    Eur J Cell Biol 90:456-66. 2011
    ..This review summarizes the work in the framework of the Collaborative Research Consortium 415 (CRC 415) and provides facts and hypotheses about FasL-interacting proteins and their potential role in FasL biology...
  27. ncbi request reprint Regulation of activation-induced cell death of mature T-lymphocyte populations
    O Janssen
    Institute for Immunology, Christian Albrechts University, Kiel, Germany
    Cell Tissue Res 301:85-99. 2000
    ....
  28. ncbi request reprint Differential regulation of activation-induced cell death in individual human T cell clones
    O Janssen
    Institute for Immunology, Christian Albrechts University, Kiel, Germany
    Int Arch Allergy Immunol 121:183-93. 2000
    ..We and others demonstrated that AICD resistance is associated with a reduced surface expression of CD95L upon restimulation...
  29. doi request reprint Signal transduction--receptors, mediators, and genes
    Frank Entschladen
    Institute of Immunology, Witten Herdecke University, Witten, Germany
    Sci Signal 2:mr3. 2009
    ..This international and interdisciplinary scientific gathering induced lively discussions and close interactions between participants...
  30. ncbi request reprint Death receptors and caspases: role in lymphocyte proliferation, cell death, and autoimmunity
    Sabine Adam-Klages
    Institut fur Immunologie, Universitätsklinikum Schleswig Holstein Campus Kiel, Kiel, Germany
    Immunol Res 33:149-66. 2005
    ....
  31. doi request reprint Cationic detergents enable the separation of membrane proteins of Plasmodium falciparum-infected erythrocytes by 2D gel electrophoresis
    Stephan Philipp
    Department of Zoophysiology, Zoological Institute, University of Kiel, Kiel, Germany
    Electrophoresis 33:1120-8. 2012
    ..By using the alternative 2D approach, characteristic host cell membrane proteins and, more importantly, membrane-associated and exported plasmodial proteins were identified that might play a role in parasite-induced host cell modulation...
  32. ncbi request reprint Identification of interaction partners of the cytosolic polyproline region of CD95 ligand (CD178)
    Markus Philipp Ghadimi
    Institute of Immunology, University Hospital Kiel, Michaelisstr 5, Kiel, Germany
    FEBS Lett 519:50-8. 2002
    ..Protein-protein interactions are mediated via Src homology 3 (SH3) domain binding to the polyproline region of CD95L and can be abolished by mutation or deletion of the respective SH3 domain...
  33. pmc Signal transduction, receptors, mediators and genes: younger than ever - the 13th meeting of the Signal Transduction Society focused on aging and immunology
    Frank Entschladen
    Institute of Immunology, Witten Herdecke University, Germany
    Cell Commun Signal 8:2. 2010
    ..This report gives an overview of the presentations of the conference...
  34. ncbi request reprint ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death
    M Schulte
    Biochemical Institute, Christian Albrecht University, Kiel, Germany
    Cell Death Differ 14:1040-9. 2007
    ..Overall, our findings suggest that ADAM10 represents an important molecular modulator of FasL-mediated cell death...
  35. doi request reprint FasL expression and reverse signalling
    M Lettau
    Institute of Immunology, University Hospital Schleswig Holstein Campus Kiel, Michaelisstr 5, D 24105 Kiel, Germany
    Results Probl Cell Differ 49:49-61. 2009
    ....
  36. pmc Differential surface expression of ADAM10 and ADAM17 on human T lymphocytes and tumor cells
    Henriette Ebsen
    University of Kiel, Institute for Immunology, University Hospital Schleswig Holstein Campus Kiel, Kiel, Germany
    PLoS ONE 8:e76853. 2013
    ....
  37. ncbi request reprint Patterns of chemokine receptor expression on peripheral blood gamma delta T lymphocytes: strong expression of CCR5 is a selective feature of V delta 2/V gamma 9 gamma delta T cells
    Andrea Glatzel
    Institute of Immunology, University of Kiel, Michaelisstrasse 5, D 24105 Kiel, Germany
    J Immunol 168:4920-9. 2002
    ..Our results identify high level expression of CCR5 as a characteristic and selective feature of circulating Vdelta2 gammadelta T cells, which is in line with their suspected function as Th1 effector T cells...
  38. pmc Pro- and anti-apoptotic CD95 signaling in T cells
    Maren Paulsen
    Christian Albrechts University of Kiel Institute of Immunology, University Hospital Schleswig Holstein Campus Kiel, Arnold Heller Str, 3 Bldg 17, D 24105 Kiel, Germany
    Cell Commun Signal 9:7. 2011
    ....
  39. pmc Nck adapter proteins: functional versatility in T cells
    Marcus Lettau
    University Hospital Schleswig Holstein Campus Kiel, Institute of Immunology, Molecular Immunology, Arnold Heller Str 3, Bldg 17, D 24105 Kiel, Germany
    Cell Commun Signal 7:1. 2009
    ..g. in the control of gene expression and proliferation...
  40. ncbi request reprint Regulation of T-cell death-associated gene 51 (TDAG51) expression in human T-cells
    H H Oberg
    Institute of Immunology, University Hospital Schleswig Holstein Campus Kiel, Kiel, Germany
    Cell Death Differ 11:674-84. 2004
    ..Our results indicate that the expression of TDAG51 in human T-cells does not correlate with AICD...
  41. ncbi request reprint Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor
    J Wenzel
    Institute for Immunology, Christian Albrechts University, Michaelisstrasse 5, 24105 Kiel, Germany
    FEBS Lett 509:255-62. 2001
    ..These results may help to explain the costimulatory capacity of CD95L...