H Jahn

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. ncbi request reprint Sleep endocrine effects of the 11-beta-hydroxysteroiddehydrogenase inhibitor metyrapone
    Holger Jahn
    Department of Psychiatry and Psychotherapy, University of Hamburg, Hamburg, Germany
    Sleep 26:823-9. 2003
  2. ncbi request reprint Activation of guanylate cyclase by natriuretic peptides in mouse pituitary AtT20 cells is influenced by phosphorylation of ANP
    H Jahn
    Clinic of Psychiatry and Psychotherapy, University of Hamburg, Germany
    Neurochem Res 26:473-8. 2001
  3. pmc Peptide fingerprinting of Alzheimer's disease in cerebrospinal fluid: identification and prospective evaluation of new synaptic biomarkers
    Holger Jahn
    Department of Psychiatry, University Hospital Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 6:e26540. 2011
  4. ncbi request reprint Alpha-helical-corticotropin-releasing hormone reverses anxiogenic effects of C-type natriuretic peptide in rats
    H Jahn
    University of Hamburg, Department of Psychiatry and Psychotherapy, Martinistr 52, 20251 Hamburg, Germany
    Brain Res 893:21-8. 2001
  5. ncbi request reprint Metyrapone as additive treatment in major depression: a double-blind and placebo-controlled trial
    Holger Jahn
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Arch Gen Psychiatry 61:1235-44. 2004
  6. ncbi request reprint [Diabetes mellitus as a complication of treatment with atypical neuroleptics. Possible pathomechanisms and treatment recommendations]
    H Jahn
    Klinik fur Psychiatrie und Psychotherapie, Universitat Hamburg
    Nervenarzt 75:442-50. 2004
  7. doi request reprint Amyloid beta peptides in plasma in early diagnosis of Alzheimer's disease: A multicenter study with multiplexing
    P Lewczuk
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Exp Neurol 223:366-70. 2010
  8. ncbi request reprint Leptin: a modulator of alcohol craving?
    F Kiefer
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg, Hamburg, Germany
    Biol Psychiatry 49:782-7. 2001
  9. ncbi request reprint A combination of galantamine and memantine modifies cognitive function in subjects with amnestic MCI
    O Peters
    Department of Psychiatry, Charite Campus Benjamin Franklin, Berlin, Germany
    J Nutr Health Aging 16:544-8. 2012
  10. doi request reprint Biomarker validation of a cued recall memory deficit in prodromal Alzheimer disease
    M Wagner
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Neurology 78:379-86. 2012

Detail Information

Publications42

  1. ncbi request reprint Sleep endocrine effects of the 11-beta-hydroxysteroiddehydrogenase inhibitor metyrapone
    Holger Jahn
    Department of Psychiatry and Psychotherapy, University of Hamburg, Hamburg, Germany
    Sleep 26:823-9. 2003
    ....
  2. ncbi request reprint Activation of guanylate cyclase by natriuretic peptides in mouse pituitary AtT20 cells is influenced by phosphorylation of ANP
    H Jahn
    Clinic of Psychiatry and Psychotherapy, University of Hamburg, Germany
    Neurochem Res 26:473-8. 2001
    ..The activity of CNP was unaffected in these experiments. Phosphorylation by ectokinases may be a physiological mechanism to regulate the biological activity of ANP in different tissues, such as pituitary and CNS...
  3. pmc Peptide fingerprinting of Alzheimer's disease in cerebrospinal fluid: identification and prospective evaluation of new synaptic biomarkers
    Holger Jahn
    Department of Psychiatry, University Hospital Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 6:e26540. 2011
    ....
  4. ncbi request reprint Alpha-helical-corticotropin-releasing hormone reverses anxiogenic effects of C-type natriuretic peptide in rats
    H Jahn
    University of Hamburg, Department of Psychiatry and Psychotherapy, Martinistr 52, 20251 Hamburg, Germany
    Brain Res 893:21-8. 2001
    ..Our data suggest opposing effects of CNP and ANP on anxiety-related behavior and neuroendocrine regulation in rats, which appear to be mediated via different receptor occupation and brain regions, and by a CRH-dependent mechanism...
  5. ncbi request reprint Metyrapone as additive treatment in major depression: a double-blind and placebo-controlled trial
    Holger Jahn
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Arch Gen Psychiatry 61:1235-44. 2004
    ..Inhibitors of steroid synthesis have been reported to exert antidepressive effects, according to preliminary findings...
  6. ncbi request reprint [Diabetes mellitus as a complication of treatment with atypical neuroleptics. Possible pathomechanisms and treatment recommendations]
    H Jahn
    Klinik fur Psychiatrie und Psychotherapie, Universitat Hamburg
    Nervenarzt 75:442-50. 2004
    ..Changes in leptin release and development of leptin resistance possibly play an important role. These new results should be considered when planning therapy, although a final risk analysis is not yet possible...
  7. doi request reprint Amyloid beta peptides in plasma in early diagnosis of Alzheimer's disease: A multicenter study with multiplexing
    P Lewczuk
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Exp Neurol 223:366-70. 2010
    ..Our findings reconfirm the hypothesis that alterations of biomarker concentrations occur early in a preclinical AD stage and that these alterations are also reflected in plasma...
  8. ncbi request reprint Leptin: a modulator of alcohol craving?
    F Kiefer
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg, Hamburg, Germany
    Biol Psychiatry 49:782-7. 2001
    ..Leptin has been shown to regulate food intake and energy expenditure. Because leptin acts via regulation of appetite, we studied the hypothesis that suggests leptin modulates craving for alcohol as well...
  9. ncbi request reprint A combination of galantamine and memantine modifies cognitive function in subjects with amnestic MCI
    O Peters
    Department of Psychiatry, Charite Campus Benjamin Franklin, Berlin, Germany
    J Nutr Health Aging 16:544-8. 2012
    ..One subtype of this syndrome, amnestic MCI, occurs preferentially but not exclusively in prodromal AD and is characterized by defined deficits of episodic memory...
  10. doi request reprint Biomarker validation of a cued recall memory deficit in prodromal Alzheimer disease
    M Wagner
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Neurology 78:379-86. 2012
    ..To compare cued recall measures with other memory and nonmemory tests regarding their association with a biomarker profile indicative of Alzheimer disease (AD) in CSF among patients with mild cognitive impairment (MCI)...
  11. ncbi request reprint Anxiolyticlike effects of atrial natriuretic peptide on cholecystokinin tetrapeptide-induced panic attacks: preliminary findings
    K Wiedemann
    Department of Psychiatry and Psychotherapy, University of Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
    Arch Gen Psychiatry 58:371-7. 2001
    ....
  12. doi request reprint Soluble amyloid precursor proteins in the cerebrospinal fluid as novel potential biomarkers of Alzheimer's disease: a multicenter study
    P Lewczuk
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Mol Psychiatry 15:138-45. 2010
    ..001), from the patients clinically assessed as having other dementias and supported by NDD untypical for AD. We conclude sAPP alpha and sAPP beta might be regarded as novel promising biomarkers supporting the clinical diagnosis of AD...
  13. ncbi request reprint Free-choice alcohol consumption in mice after application of the appetite regulating peptide leptin
    F Kiefer
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg, Hamburg, Germany
    Alcohol Clin Exp Res 25:787-9. 2001
    ..Therefore, we tested the hypothesis that the application of exogenous leptin modulates voluntary alcohol consumption in mice...
  14. ncbi request reprint Effects of natriuretic peptides upon hypothalamo-pituitary-adrenocortical system activity and anxiety behaviour
    K Wiedemann
    University of Hamburg, Dept of Psychiatry and Psychotherapy, Germany
    Exp Clin Endocrinol Diabetes 108:5-13. 2000
    ..Hence, it may be surmised that in man and rodents ANP reduces anxiety and terminates panic attacks and their neuroendocrine sequelae...
  15. ncbi request reprint Involvement of plasma atrial natriuretic peptide in protracted alcohol withdrawal
    F Kiefer
    Department of Psychiatry, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Acta Psychiatr Scand 105:65-70. 2002
    ..We tested the hypothesis of whether ANP is associated with endocrine and psychopathological disturbances during acute alcohol withdrawal...
  16. ncbi request reprint Alcohol intake, tumour necrosis factor-alpha, leptin and craving: factors of a possibly vicious circle?
    F Kiefer
    Department of Psychiatry, University Hospital of Hamburg, Martinistrasse 52, D 20246 Hamburg, Germany
    Alcohol Alcohol 37:401-4. 2002
    ....
  17. ncbi request reprint Intravenous C-type natriuretic peptide augments behavioral and endocrine effects of cholecystokinin tetrapeptide in healthy men
    M Kellner
    University Hospital Hamburg Eppendorf, Department of Psychiatry and Psychotherapy, Martinistrasse 52, 20246 Hamburg, Germany
    J Psychiatr Res 36:1-6. 2002
    ..However, no effect of CNP was seen upon panic symptoms. Our preliminary data support a role of type-B natriuretic peptide receptors in anxiety modulation in normal man...
  18. ncbi request reprint Comparison of the effects of endothelin-1 and -3 on secretion of pituitary hormones in healthy male volunteers
    F Kiefer
    Department of Psychiatry, University Hospital Eppendorf, Hamburg, Germany
    Exp Clin Endocrinol Diabetes 108:378-81. 2000
    ..Whether this supports a possible role of ET-1 as a modulator of the hypothalamo-pituitary-adrenal (HPA) axis remains to be clarified...
  19. ncbi request reprint C-type natriuretic peptide exerts effects opposing those of atrial natriuretic peptide on anxiety-related behaviour in rats
    A Montkowski
    Max Planck Institute of Psychiatry, Clinical Institute, Department of Neuroendocrinology, Munich, Germany
    Brain Res 792:358-60. 1998
    ..Our data suggest opposing effects of CNP and ANP on anxiety-related behaviour in rats, which appear to be mediated via different receptor occupation and brain regions by a corticotropin-releasing hormone (CRH)-dependent mechanism...
  20. doi request reprint A multicenter (1)H-MRS study of the medial temporal lobe in AD and MCI
    F Jessen
    Department of Psychiatry, University of Bonn, Germany
    Neurology 72:1735-40. 2009
    ..Within the German Competence Network on Dementia, we conducted a (1)H-MRS study in patients with mild dementia and mild cognitive impairment (MCI) at four sites to investigate the multicenter feasibility of (1)H-MRS...
  21. ncbi request reprint Elevation of beta-amyloid peptide 2-42 in sporadic and familial Alzheimer's disease and its generation in PS1 knockout cells
    J Wiltfang
    Department of Psychiatry, Molecular Neurobiology, and Department of Biochemistry II, University of Gottingen, D 37073 Gottingen, Germany
    J Biol Chem 276:42645-57. 2001
    ..Moreover, our results indicate that the latter Abeta peptide species could be generated by a beta(Asp/Ala)-secretase activity...
  22. ncbi request reprint Harman and norharman plasma levels in weaned alcoholics: correlations with depression and tobacco smoking
    F Kiefer
    Department of Psychiatry, University Hospital Eppendorf, Hamburg, Germany
    Addict Biol 5:437-41. 2000
    ..The partial correlations support this hypothesis...
  23. ncbi request reprint Disruption of ClC-3, a chloride channel expressed on synaptic vesicles, leads to a loss of the hippocampus
    S M Stobrawa
    Zentrum fur Molekulare Neurobiologie Hamburg, Universitat Hamburg, Martinistrasse 85, D 20246, Hamburg, Germany
    Neuron 29:185-96. 2001
    ..Mice almost lacking the hippocampus survive and show several behavioral abnormalities but are still able to acquire motor skills...
  24. ncbi request reprint Mineralocorticoid receptor-mediated inhibition of the hypothalamic-pituitary-adrenal axis in aged humans
    Christian Otte
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Gerontol A Biol Sci Med Sci 58:B900-5. 2003
    ..Our results implicate that a decrease in MR-mediated negative feedback contributes to the diminished feedback activity in older humans...
  25. ncbi request reprint Alcohol self-administration, craving and HPA-axis activity: an intriguing relationship
    Falk Kiefer
    Psychopharmacology (Berl) 164:239-40. 2002
  26. ncbi request reprint Multiplexed quantification of dementia biomarkers in the CSF of patients with early dementias and MCI: a multicenter study
    Piotr Lewczuk
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Neurobiol Aging 29:812-8. 2008
    ..9 pg/mL. These cutoff values were also applied to discriminate between MCI-AD and MCI-O subjects. Simultaneous measurement of the biomarkers significantly improves management of the samples and quality control of the assays' performance...
  27. doi request reprint Asymmetrical dimethylarginine is increased in plasma and decreased in cerebrospinal fluid of patients with Alzheimer's disease
    Sönke Arlt
    Department of Psychiatry and Psychotherapy, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Dement Geriatr Cogn Disord 26:58-64. 2008
    ..Concerning Alzheimer's disease (AD), there are reports on altered cerebral NO metabolism, but only few studies on ADMA concentrations in plasma and cerebrospinal fluid (CSF)...
  28. ncbi request reprint Modulation of sympathetic activity by corticotropin-releasing hormone and atrial natriuretic peptide
    Josef Arlt
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
    Neuropeptides 37:362-8. 2003
    ..Hence, we attempted to investigate the ANS-effects of a CRH bolus and the modulatory influences of atrial natriuretic peptide (ANP), one of the most important functional antagonist of CRH actions...
  29. ncbi request reprint Prolactin but not ACTH increases during sodium lactate-induced panic attacks
    Christian Otte
    University Hospital Hamburg Eppendorf, Department of Psychiatry and Psychotherapy, Martinistrasse 52, 20246, Germany
    Psychiatry Res 109:201-5. 2002
    ..Prolactin release was significantly elevated (P < 0.05) in panickers compared with non-panickers, whereas ACTH secretion was not activated at all. This differential stress response needs further investigation...
  30. ncbi request reprint Hypothalamic-pituitary-adrenocortical axis activity: a target of pharmacological anticraving treatment?
    Falk Kiefer
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Biol Psychiatry 60:74-6. 2006
    ..We examined the relationship between efficacy of pharmacological anticraving treatment and HPA axis activity in the relapse prevention treatment of alcoholism...
  31. ncbi request reprint Megestrol attenuates the hormonal response to CCK-4-induced panic attacks
    Thomas J Raedler
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Depress Anxiety 23:139-44. 2006
    ..Further studies in a larger sample of subjects, including both females and patients suffering from panic disorder, seem warranted...
  32. ncbi request reprint Acute effects of megestrol on the hypothalamic-pituitary-adrenal axis
    Thomas J Raedler
    Department of Psychiatry and Psychotherapy, University of Hamburg Medical Center, Martinistr 52, 20246, Hamburg, Germany
    Cancer Chemother Pharmacol 52:482-6. 2003
    ..As part of an endocrine study, we evaluated the acute effects of megestrol, hydrocortisone and placebo on morning cortisol and ACTH levels...
  33. ncbi request reprint Dimensional structure of the Hamilton Depression Rating Scale in patients with obsessive-compulsive disorder
    Steffen Moritz
    University Hospital Hamburg Eppendorf, Hospital for Psychiatry and Psychotherapy, Martinistrasse 52, 20246 Hamburg, Germany
    Psychiatry Res 125:171-80. 2004
    ....
  34. ncbi request reprint Overnight metyrapone and combined dexamethasone/metyrapone tests in post-traumatic stress disorder: preliminary findings
    Michael Kellner
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Eur Neuropsychopharmacol 14:337-9. 2004
    ..Dose-response studies using metyrapone and glucocorticoid agonists are needed to further investigate HPA axis regulation in PTSD...
  35. ncbi request reprint The mineralocorticoid receptor agonist, fludrocortisone, inhibits pituitary-adrenal activity in humans after pre-treatment with metyrapone
    Christian Otte
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Life Sci 73:1835-45. 2003
    ..05), whereas no such effect was observed after aldosterone or placebo. These preliminary data suggest that MR are involved in the inhibition of the HPA axis during the circadian nadir of glucocorticoid concentrations in humans...
  36. ncbi request reprint Adjunctive use of reboxetine in schizophrenia
    Thomas J Raedler
    University Hospital Hamburg Eppendorf, Department of Psychiatry and Psychotherapy, Martini str 52, 20246 Hamburg, Germany
    Eur Psychiatry 19:366-9. 2004
    ..We sought to study the efficacy and tolerability of the adjunctive use of reboxetine in a cohort of schizophrenic patients with prominent depressive or negative symptoms...
  37. ncbi request reprint Comparing and combining naltrexone and acamprosate in relapse prevention of alcoholism: a double-blind, placebo-controlled study
    Falk Kiefer
    Department of Psychiatry, University Hospital of Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    Arch Gen Psychiatry 60:92-9. 2003
    ..Since it remains uncertain whether both substances are equally efficient and whether a combination of both drugs potentiates the efficacy, we conducted the first published controlled study comparing and combining both compounds...
  38. ncbi request reprint Is withdrawal-induced anxiety in alcoholism based on beta-endorphin deficiency?
    Falk Kiefer
    Department of Psychiatry, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20251 Hamburg, Germany
    Psychopharmacology (Berl) 162:433-7. 2002
    ..During alcohol withdrawal, a decreased secretion of beta E with a delayed normalization has been reported, but up to now only few data became available regarding the interaction of plasma beta E and psychopathological parameters...
  39. ncbi request reprint Amyloid beta peptide ratio 42/40 but not A beta 42 correlates with phospho-Tau in patients with low- and high-CSF A beta 40 load
    Jens Wiltfang
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    J Neurochem 101:1053-9. 2007
    ..We conclude that the amyloid beta concentration ratio should replace the 'raw' concentrations of corresponding A beta peptides to improve reliability of the neurochemical dementia diagnosis...
  40. ncbi request reprint Pharmacological relapse prevention of alcoholism: clinical predictors of outcome
    Falk Kiefer
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health CIMH, University of Heidelberg, Heidelberg, Germany
    Eur Addict Res 11:83-91. 2005
    ..The efficacy of pharmacological relapse prevention in alcoholism with acamprosate and naltrexone has been supported by several controlled trials. It remains uncertain whether any differential indication for treatment exists...
  41. ncbi request reprint Increasing leptin precedes craving and relapse during pharmacological abstinence maintenance treatment of alcoholism
    Falk Kiefer
    Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health CIMH, University of Heidelberg, J5, 68159 Mannheim, Germany
    J Psychiatr Res 39:545-51. 2005
    ..Moreover, there are hints for an interaction between pharmacological anti-craving treatment, plasma concentration of leptin, and abstinence duration...
  42. ncbi request reprint Effects of treatment with acamprosate on beta-endorphin plasma concentration in humans with high alcohol preference
    Falk Kiefer
    Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health CIMH, University of Heidelberg, Mannheim, Germany
    Neurosci Lett 404:103-6. 2006
    ....