Rolf D Issels

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi request reprint Novel temperature-sensitive liposomes with prolonged circulation time
    Lars H Lindner
    Department of Internal Medicine III, Klinikum Grosshadern Medical Center KGMC, Ludwig Maximilians University, Munich, Germany
    Clin Cancer Res 10:2168-78. 2004
  2. ncbi request reprint The role of hyperthermia in combined treatment in the management of soft tissue sarcoma
    Rolf D Issels
    University Hospital Medical Center Grosshadern Medical Clinic III, GSF National Research Center for the Environment and Health, 81377 Munich, Germany
    Curr Oncol Rep 8:305-9. 2006
  3. ncbi request reprint Emerging treatments for soft tissue sarcoma of adults
    Werner Fahn
    Medizinische Klinik III, Klinikum Grosshadern, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Expert Opin Emerg Drugs 9:313-34. 2004
  4. doi request reprint Regional hyperthermia in high-risk soft tissue sarcomas
    Rolf D Issels
    University Hospital Medical Center Grosshadern, Medical Clinic III and Helmholtz Zentrum münchen German Research Center for Environmetal Health, Munich, Germany
    Curr Opin Oncol 20:438-43. 2008
  5. pmc Neo-adjuvant chemotherapy alone or with regional hyperthermia for localised high-risk soft-tissue sarcoma: a randomised phase 3 multicentre study
    Rolf D Issels
    Klinikum der Universität München Campus Grosshadern, Munchen, Germany
    Lancet Oncol 11:561-70. 2010
  6. pmc Anti-tumor activity of patient-derived NK cells after cell-based immunotherapy--a case report
    Valeria Milani
    Department of Internal Medicine, University Medical Center Grosshadern, Ludwig Maximilians Universitat Munchen, Germany
    J Transl Med 7:50. 2009
  7. doi request reprint Hyperthermia adds to chemotherapy
    Rolf D Issels
    University of Munich, Campus Grosshadern, Medical Clinic III, Munich, Germany
    Eur J Cancer 44:2546-54. 2008
  8. ncbi request reprint High-risk soft tissue sarcoma: clinical trial and hyperthermia combined chemotherapy
    Rolf D Issels
    University Hospital Medical Center Grosshadern, Medical Clinic III, LMU Munich and KKG Hyperthermie, GSF, National Research Center for Environment and Health, Munich, Germany
    Int J Hyperthermia 22:235-9. 2006
  9. doi request reprint Non-ionic Gd-based MRI contrast agents are optimal for encapsulation into phosphatidyldiglycerol-based thermosensitive liposomes
    Martin Hossann
    Department of Internal Medicine III, University Hospital of Munich, Ludwig Maximilians University, Munich, Germany
    J Control Release 166:22-9. 2013
  10. doi request reprint Size of thermosensitive liposomes influences content release
    Martin Hossann
    Department of Internal Medicine III, University Hospital Grosshadern, Ludwig Maximilians University, Munich, Germany
    J Control Release 147:436-43. 2010

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Novel temperature-sensitive liposomes with prolonged circulation time
    Lars H Lindner
    Department of Internal Medicine III, Klinikum Grosshadern Medical Center KGMC, Ludwig Maximilians University, Munich, Germany
    Clin Cancer Res 10:2168-78. 2004
    ..This adds positively to the results with lipid-grafted polyethylenglycol used thus far in temperature sensitive liposomes and widens the possibilities for clinical applications...
  2. ncbi request reprint The role of hyperthermia in combined treatment in the management of soft tissue sarcoma
    Rolf D Issels
    University Hospital Medical Center Grosshadern Medical Clinic III, GSF National Research Center for the Environment and Health, 81377 Munich, Germany
    Curr Oncol Rep 8:305-9. 2006
    ..This short overview summarizes the results of the combination with regional hyperthermia as a new treatment strategy to open a new therapeutic window...
  3. ncbi request reprint Emerging treatments for soft tissue sarcoma of adults
    Werner Fahn
    Medizinische Klinik III, Klinikum Grosshadern, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Expert Opin Emerg Drugs 9:313-34. 2004
    ..The main body of the review summarises information on new and emerging clinical compounds for patients with soft tissue sarcoma of adults, including recent developments of targeted therapy...
  4. doi request reprint Regional hyperthermia in high-risk soft tissue sarcomas
    Rolf D Issels
    University Hospital Medical Center Grosshadern, Medical Clinic III and Helmholtz Zentrum münchen German Research Center for Environmetal Health, Munich, Germany
    Curr Opin Oncol 20:438-43. 2008
    ..On the basis of the definition of high-risk soft tissue sarcomas and prognostic factors, the most recent developments of preoperative treatment strategies with special emphasis on regional hyperthermia combined chemotherapy are reviewed...
  5. pmc Neo-adjuvant chemotherapy alone or with regional hyperthermia for localised high-risk soft-tissue sarcoma: a randomised phase 3 multicentre study
    Rolf D Issels
    Klinikum der Universität München Campus Grosshadern, Munchen, Germany
    Lancet Oncol 11:561-70. 2010
    ..We designed a parallel-group randomised controlled trial to assess the safety and efficacy of regional hyperthermia with chemotherapy...
  6. pmc Anti-tumor activity of patient-derived NK cells after cell-based immunotherapy--a case report
    Valeria Milani
    Department of Internal Medicine, University Medical Center Grosshadern, Ludwig Maximilians Universitat Munchen, Germany
    J Transl Med 7:50. 2009
    ..This study investigated the maintenance of the cytolytic activity of NK cells against K562 cells and autologous tumor after 6 plus 3 infusions of TKD/IL-2-activated effector cells...
  7. doi request reprint Hyperthermia adds to chemotherapy
    Rolf D Issels
    University of Munich, Campus Grosshadern, Medical Clinic III, Munich, Germany
    Eur J Cancer 44:2546-54. 2008
    ..In Europe, more specialised centres should be created and maintained as network of excellence for hyperthermia in the field of oncology...
  8. ncbi request reprint High-risk soft tissue sarcoma: clinical trial and hyperthermia combined chemotherapy
    Rolf D Issels
    University Hospital Medical Center Grosshadern, Medical Clinic III, LMU Munich and KKG Hyperthermie, GSF, National Research Center for Environment and Health, Munich, Germany
    Int J Hyperthermia 22:235-9. 2006
    ..This short overview summarizes the results of the combination with regional hyperthermia as a new treatment strategy to open a new therapeutic window...
  9. doi request reprint Non-ionic Gd-based MRI contrast agents are optimal for encapsulation into phosphatidyldiglycerol-based thermosensitive liposomes
    Martin Hossann
    Department of Internal Medicine III, University Hospital of Munich, Ludwig Maximilians University, Munich, Germany
    J Control Release 166:22-9. 2013
    ..Hence, the optimal CA is characterized by a non-ionic structure and a low contribution to osmolality...
  10. doi request reprint Size of thermosensitive liposomes influences content release
    Martin Hossann
    Department of Internal Medicine III, University Hospital Grosshadern, Ludwig Maximilians University, Munich, Germany
    J Control Release 147:436-43. 2010
    ..Even small changes in size or a wider size distribution might affect stability and release properties and thus yield in decreased efficacy or unwanted side effects of drug loaded TSL during in vivo applications...
  11. doi request reprint Proteins and cholesterol lipid vesicles are mediators of drug release from thermosensitive liposomes
    Martin Hossann
    Department of Internal Medicine III, University Hospital Munich, Ludwig Maximilians University, Munich, Germany
    J Control Release 162:400-6. 2012
    ..Hence, the use of plasma or serum is still inevitable to investigate stability and release properties of novel TSL formulations until all serum components have been identified that alter TSL integrity...
  12. ncbi request reprint Response to neoadjuvant chemotherapy combined with regional hyperthermia predicts long-term survival for adult patients with retroperitoneal and visceral high-risk soft tissue sarcomas
    Clemens M Wendtner
    Department of Internal Medicine III, Diagnostic Radiology and Institute for Biostatistics and Epidemiology, Klinikum Grosshadern Medical Center, Ludwig Maximilians University, Munich, Germany
    J Clin Oncol 20:3156-64. 2002
    ....
  13. doi request reprint In vitro characterization of phosphatidylglyceroglycerol-based thermosensitive liposomes with encapsulated 1H MR T1-shortening gadodiamide
    Tungte Wang
    Department of Internal Medicine III, University Hospital Grosshadern, University of Munich, Munich, Germany
    Contrast Media Mol Imaging 3:19-26. 2008
    ....
  14. ncbi request reprint Dual role of hexadecylphosphocholine (miltefosine) in thermosensitive liposomes: active ingredient and mediator of drug release
    Lars H Lindner
    Department of Medicine III, University Hospital Grosshadern, Ludwig Maximilians University, Munich, Germany
    J Control Release 125:112-20. 2008
    ..A possible explanation for this raise in cytotoxicity of HePC in TSL is the increased cellular transfer of HePC under heating conditions demonstrated by LC-MS/MS...
  15. doi request reprint Hsp70, a messenger from hyperthermia for the immune system
    Anna Jolesch
    Helmholtz Zentrum Munchen German Research Center for Environmental Health, Institute of Molecular Immunology, Marchioninistrasse 25, Munich, Germany
    Eur J Cell Biol 91:48-52. 2012
    ..Further, we discuss that clinical hyperthermia could be a way to initiate the immunologic activity of Hsp70 by upregulating its expression and facilitating release through local necrosis...
  16. ncbi request reprint In vitro stability and content release properties of phosphatidylglyceroglycerol containing thermosensitive liposomes
    Martin Hossann
    Department of Internal Medicine III, Klinikum Grosshadern Medical Center KGMC, Ludwig Maximilians University, Munich, Germany
    Biochim Biophys Acta 1768:2491-9. 2007
    ....
  17. ncbi request reprint Ferrite-enhanced MRI monitoring in hyperthermia
    Herbert M Reinl
    Department of Clinical Radiology, Ludwig Maximilians University Munich, Grosshadern, D 81377 Munich, Germany
    Magn Reson Imaging 23:1017-20. 2005
    ..The ferrofluid is stable and allows RF heating at 100 MHz. This method of signal extinction may also be useful for other experimental setups where suppression of water is necessary...
  18. doi request reprint Comparison of radiological and pathohistological response to neoadjuvant chemotherapy combined with regional hyperthermia (RHT) and study of response dependence on the applied thermal parameters in patients with soft tissue sarcomas (STS)
    Robert Stahl
    Department of Internal Medicine III, University Hospitals Grosshadern Campus, Ludwig Maximilians University of Munich, D 81377 Munich, Germany
    Int J Hyperthermia 25:289-98. 2009
    ....
  19. ncbi request reprint Human heat shock protein 70 enhances tumor antigen presentation through complex formation and intracellular antigen delivery without innate immune signaling
    Henriette Bendz
    Institute of Molecular Immunology, GSF National Research Center for Environment and Health Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistrasse 25, 81377 Munich, Germany
    J Biol Chem 282:31688-702. 2007
    ..As Hsp70 supports the cross-presentation of different antigens and APCs and is inert to APC function, it may show efficacy in various settings of immune modulation, including induction of antigen-specific immunity or tolerance...
  20. ncbi request reprint Ifosfamide impairs the allostimulatory capacity of human dendritic cells by intracellular glutathione depletion
    Maria C Kuppner
    Klinikum Grosshadern Medical Clinic II, Ludwig Maximillians University, Munich, Germany
    Blood 102:3668-74. 2003
    ..These studies suggest that in cancer patients treated with ifosfamide, protection strategies based on glutathione reconstitution may enhance DC function...
  21. doi request reprint Hyperthermia in soft tissue sarcoma
    Lars H Lindner
    University of Munich, Munich, Germany
    Curr Treat Options Oncol 12:12-20. 2011
    ....
  22. doi request reprint Oral capecitabine in gemcitabine-pretreated patients with advanced pancreatic cancer
    Stefan Boeck
    Department ofInternal Medicine III, Klinikum Grosshadern, Ludwig Maximilians University of Munich, Munich, Germany
    Oncology 73:221-7. 2007
    ..Oral capecitabine (Cap) has shown promising activity in first-line chemotherapy trials in PC patients...
  23. ncbi request reprint T1 relaxation time at 0.2 Tesla for monitoring regional hyperthermia: feasibility study in muscle and adipose tissue
    Michael Peller
    Department of Clinical Radiology, Ludwig Maximilians University, Munich, Grosshadern, Germany
    Magn Reson Med 47:1194-201. 2002
    ..T(1) mapping allows the characterization of hyperthermia-related tissue response in healthy tissue. T(1), in combination with fast mapping, is suitable for controlling regional hyperthermia at 0.2 T within the hybrid system...