Berend Isermann

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi Autoantibodies in diabetes mellitus: current utility and perspectives
    B Isermann
    Department of Internal Medicine I Endocrinology and Clinical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany
    Exp Clin Endocrinol Diabetes 115:483-90. 2007
  2. ncbi [Relevance of platelets in placental development and function]
    B Isermann
    Abteilung Innere Medizin I und Klinische Chemie, INF 410, Universitat Heidelberg, 69120 Heidelberg
    Hamostaseologie 27:263-7. 2007
  3. ncbi The role of platelets during reproduction
    Berend Isermann
    Department of Internal Medicine I and Clinical Chemistry, University of Heidelberg, Germany
    Pathophysiol Haemost Thromb 35:23-7. 2006
  4. ncbi Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis
    Berend Isermann
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, INF 410, 69120 Heidelberg, Germany
    Nat Med 13:1349-58. 2007
  5. ncbi [AGE-RAGE: a hypothesis or a mechanism?]
    Berend Isermann
    Abteilung Endokrinologie und Stoffwechsel, Universitätsklinik Heidelberg, Heidelberg
    Herz 29:504-9. 2004
  6. ncbi Nuclear factor erythroid-derived 2 (Nfe2) regulates JunD DNA-binding activity via acetylation: a novel mechanism regulating trophoblast differentiation
    Muhammed Kashif
    Department of Internal Medicine I and Clinical Chemistry, University of Heidelberg, INF 410, 69120 Heidelberg, Germany
    J Biol Chem 287:5400-11. 2012
  7. ncbi Hypercoagulability inhibits monocyte transendothelial migration through protease-activated receptor-1-, phospholipase-Cbeta-, phosphoinositide 3-kinase-, and nitric oxide-dependent signaling in monocytes and promotes plaque stability
    Stefanie Seehaus
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, INF 410, 69120 Heidelberg, Germany
    Circulation 120:774-84. 2009
  8. ncbi Minocycline reduces plaque size in diet induced atherosclerosis via p27(Kip1)
    Khurrum Shahzad
    Internal Medicine I and Clinical Chemistry, University of Heidelberg, INF 410, 69120 Heidelberg, Germany
    Atherosclerosis 219:74-83. 2011
  9. ncbi Evaluation of plaque stability of advanced atherosclerotic lesions in apo E-deficient mice after treatment with the oral factor Xa inhibitor rivaroxaban
    Qianxing Zhou
    Department of Internal Medicine III, University of Heidelberg, 69120 Heidelberg, Germany
    Mediators Inflamm 2011:432080. 2011
  10. ncbi Long-term administration of 3-deazaadenosine does not alter progression of advanced atherosclerotic lesions in apolipoprotein E-deficient mice
    Michael R Preusch
    Department of Internal Medicine III, University of Heidelberg, Germany
    J Cardiovasc Pharmacol 50:206-12. 2007

Collaborators

Detail Information

Publications31

  1. ncbi Autoantibodies in diabetes mellitus: current utility and perspectives
    B Isermann
    Department of Internal Medicine I Endocrinology and Clinical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany
    Exp Clin Endocrinol Diabetes 115:483-90. 2007
    ..This review focuses on the current knowledge about antibody assays for diabetes associated autoimmunity, their clinical value, their role in diagnosing and predicting autoimmune associated diabetes mellitus, and research applications...
  2. ncbi [Relevance of platelets in placental development and function]
    B Isermann
    Abteilung Innere Medizin I und Klinische Chemie, INF 410, Universitat Heidelberg, 69120 Heidelberg
    Hamostaseologie 27:263-7. 2007
    ....
  3. ncbi The role of platelets during reproduction
    Berend Isermann
    Department of Internal Medicine I and Clinical Chemistry, University of Heidelberg, Germany
    Pathophysiol Haemost Thromb 35:23-7. 2006
    ....
  4. ncbi Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis
    Berend Isermann
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, INF 410, 69120 Heidelberg, Germany
    Nat Med 13:1349-58. 2007
    ..Conversely, maintaining high APC levels during long-term diabetes protects against diabetic nephropathy...
  5. ncbi [AGE-RAGE: a hypothesis or a mechanism?]
    Berend Isermann
    Abteilung Endokrinologie und Stoffwechsel, Universitätsklinik Heidelberg, Heidelberg
    Herz 29:504-9. 2004
    ..Thus, further studies are needed for the characterization of the ligand-RAGE-interaction. These studies will provide a rationale for the development of new therapeutic approaches for accelerated atherosclerosis in diabetes mellitus...
  6. ncbi Nuclear factor erythroid-derived 2 (Nfe2) regulates JunD DNA-binding activity via acetylation: a novel mechanism regulating trophoblast differentiation
    Muhammed Kashif
    Department of Internal Medicine I and Clinical Chemistry, University of Heidelberg, INF 410, 69120 Heidelberg, Germany
    J Biol Chem 287:5400-11. 2012
    ..This identifies a novel mechanism through which bZip transcription factors interact. Within the placenta this interaction regulates Gcm1 expression, syncytiotrophoblast formation, placental vascularization, and embryonic growth...
  7. ncbi Hypercoagulability inhibits monocyte transendothelial migration through protease-activated receptor-1-, phospholipase-Cbeta-, phosphoinositide 3-kinase-, and nitric oxide-dependent signaling in monocytes and promotes plaque stability
    Stefanie Seehaus
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, INF 410, 69120 Heidelberg, Germany
    Circulation 120:774-84. 2009
    ..These seemingly opposing data suggest that hypercoagulability might exert both proatherogenic and antiatherogenic effects. We therefore investigated whether hypercoagulability mediates a beneficial effect during de novo atherogenesis...
  8. ncbi Minocycline reduces plaque size in diet induced atherosclerosis via p27(Kip1)
    Khurrum Shahzad
    Internal Medicine I and Clinical Chemistry, University of Heidelberg, INF 410, 69120 Heidelberg, Germany
    Atherosclerosis 219:74-83. 2011
    ..Whether minocycline has an effect on primary atherogenesis remains unknown...
  9. ncbi Evaluation of plaque stability of advanced atherosclerotic lesions in apo E-deficient mice after treatment with the oral factor Xa inhibitor rivaroxaban
    Qianxing Zhou
    Department of Internal Medicine III, University of Heidelberg, 69120 Heidelberg, Germany
    Mediators Inflamm 2011:432080. 2011
    ..We assessed the hypothesis that rivaroxaban, a direct FXa inhibitor, attenuates plaque progression and promotes stability of advanced atherosclerotic lesions in an in vivo model...
  10. ncbi Long-term administration of 3-deazaadenosine does not alter progression of advanced atherosclerotic lesions in apolipoprotein E-deficient mice
    Michael R Preusch
    Department of Internal Medicine III, University of Heidelberg, Germany
    J Cardiovasc Pharmacol 50:206-12. 2007
    ....
  11. ncbi Low but sustained coagulation activation ameliorates glucose-induced podocyte apoptosis: protective effect of factor V Leiden in diabetic nephropathy
    Hongjie Wang
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany
    Blood 117:5231-42. 2011
    ..These results identify a nephroprotective function of low but sustained thrombin levels in FVL carriers, supporting a dual, context-dependent function of thrombin in chronic diseases...
  12. ncbi Human RAGE antibody protects against AGE-mediated podocyte dysfunction
    Sandra Muller-Krebs
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Nephrol Dial Transplant 27:3129-36. 2012
    ..We hypothesize that GDP and AGE affect the structure and function of podocytes and investigate whether these effects can be rescued by human RAGE antibody (hRAGEab) to prevent AGE/RAGE interaction and podocyte damage...
  13. ncbi Anti-atherosclerotic properties of telmisartan in advanced atherosclerotic lesions in apolipoprotein E deficient mice
    Erwin Blessing
    Medizinische Klinik III, Universitat Heidelberg, Heidelberg, Germany
    Atherosclerosis 199:295-303. 2008
    ....
  14. ncbi p45NF-E2 represses Gcm1 in trophoblast cells to regulate syncytium formation, placental vascularization and embryonic growth
    Muhammed Kashif
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, INF 410, 69120 Heidelberg, Germany
    Development 138:2235-47. 2011
    ..These studies identify a novel function of p45NF-E2 during placental development: in trophoblast cells, p45NF-E2 represses Gcm1 and syncytiotrophoblast formation via acetylation...
  15. ncbi Protein C concentrate controls leukocyte recruitment during inflammation and improves survival during endotoxemia after efficient in vivo activation
    David Frommhold
    Department of Neonatology, University Children s Hospital, Heidelberg, Germany
    Am J Pathol 179:2637-50. 2011
    ..We conclude that during acute inflammation and sepsis, PC is a fast acting and effective therapeutic approach to block leukocyte recruitment and improve survival...
  16. ncbi Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with a reduced prevalence of diabetic neuropathy in patients with type 2 diabetes
    Gottfried Rudofsky
    Department Medicine I, University of Heidelberg, Heidelberg, Germany
    Diabetes Care 27:179-83. 2004
    ..To establish whether single nucleotide polymorphisms (Asp299Gly and Thr399Ile) of the toll-like receptor 4 have an association with late diabetic complications...
  17. ncbi Effect of alpha-lipoic acid on the progression of endothelial cell damage and albuminuria in patients with diabetes mellitus: an exploratory study
    M Morcos
    Department of Internal Medicine I, University of Heidelberg, Bergheimerstr 58, 69115 Heidelberg, Germany
    Diabetes Res Clin Pract 52:175-83. 2001
    ..Furthermore, progression of the disease might be inhibited by antioxidant drugs. A placebo-controlled study is needed...
  18. ncbi [Prevention of type 2 diabetes mellitus: proven and new aspects]
    R A Ritzel
    Medizinische Klinik I, , 69120 Heidelberg
    Dtsch Med Wochenschr 132:1057-61. 2007
  19. ncbi A 63bp deletion in the promoter of rage correlates with a decreased risk for nephropathy in patients with type 2 diabetes
    G Rudofsky
    Department of Medicine I, Otto Meyerhof Zentrum and Department of Nephrology, University of Heidelberg, Germany
    Exp Clin Endocrinol Diabetes 112:135-41. 2004
    ..The observed difference between type 1 and type 2 diabetes might point to diverse pathomechanisms of nephropathy in both types of diabetes...
  20. ncbi Hepatic arterial infusion enhances DOTATOC radiopeptide therapy in patients with neuroendocrine liver metastases
    Clemens Kratochwil
    Department of Nuclear Medicine, University Hospital Heidelberg, INF 400, 69120 Heidelberg, Germany
    Endocr Relat Cancer 18:595-602. 2011
    ....
  21. ncbi Targeting activation of specific NF-κB subunits prevents stress-dependent atherothrombotic gene expression
    Zdenka Djuric
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany
    Mol Med 18:1375-86. 2012
    ....
  22. ncbi Melagatran reduces advanced atherosclerotic lesion size and may promote plaque stability in apolipoprotein E-deficient mice
    Florian Bea
    Medizinische Klinik III, , 69120 Heidelberg, Germany
    Arterioscler Thromb Vasc Biol 26:2787-92. 2006
    ....
  23. ncbi The protein C system (TM EPCR)
    B Isermann
    Department of Internal Medicine I, University of Heidelberg, Germany
    Thromb Res 115:34-9. 2005
  24. ncbi Steroid-refractory GVHD: T-cell attack within a vulnerable endothelial system
    Thomas Luft
    Department of Medicine V, University of Heidelberg, Heidelberg, Germany
    Blood 118:1685-92. 2011
    ..These results suggest that endothelial cell vulnerability and dysfunction, rather than refractory T-cell activity, drives treatment refractoriness of GVHD and opens new avenues for prediction and control of this devastating condition...
  25. ncbi [Neuroendocrine carcinoma of the lung: a diagnostic and therapeutic challenge]
    Claudia Böttger
    Innere Medizin I und Klinische Chemie, Universitat Heidelberg, Heidelberg, Germany
    Med Klin (Munich) 105:237-41. 2010
    ..Based on this case, the diagnostic criteria, prognostic factors and therapeutic options of neuroendocrine bronchial carcinomas are discussed...
  26. ncbi Reduction of postprandial hyperglycemia in patients with type 2 diabetes reduces NF-kappaB activation in PBMCs
    G Rudofsky
    Department of Medicine I, University of Heidelberg, Germany
    Horm Metab Res 36:630-8. 2004
    ....
  27. ncbi Glimepiride reduces mononuclear activation of the redox-sensitive transcription factor nuclear factor-kappa B
    S Schiekofer
    Department of Medicine I, University of Heidelberg, Heidelberg, Germany
    Diabetes Obes Metab 5:251-61. 2003
    ..Finally, a cell-free detection system showed that glimepiride has radical quenching properties. CONCLUSION: Glimepiride can affect the activation of the redox-sensitive transcription factor NF-kappaB in vitro and in vivo...
  28. ncbi Maternal Par4 and platelets contribute to defective placenta formation in mouse embryos lacking thrombomodulin
    Rashmi Sood
    Blood Research Institute, Blood Center of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Blood 112:585-91. 2008
    ..Our findings demonstrate that fetal prothrombotic mutations can cause localized activation of maternal platelets at the feto-maternal interface in a mother with normal hemostatic function...
  29. ncbi The thrombomodulin-protein C system is essential for the maintenance of pregnancy
    Berend Isermann
    Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, Wisconsin, USA
    Nat Med 9:331-7. 2003
    ..These findings show a new function for the thrombomodulin-protein C system in controlling the growth and survival of trophoblast cells in the placenta. This function is essential for the maintenance of pregnancy...
  30. ncbi The role of junctional adhesion molecule-C (JAM-C) in oxidized LDL-mediated leukocyte recruitment
    Tanja Keiper
    Experimental Immunology Branch, NCI, NIH, Bethesda, Maryland 20892, USA
    FASEB J 19:2078-80. 2005
    ..JAM-C may therefore provide a novel molecular target for antagonizing interactions between vascular cells in atherosclerosis...
  31. ncbi Lipoprotein(a) in atherosclerotic plaques recruits inflammatory cells through interaction with Mac-1 integrin
    Sotirios N Sotiriou
    Experimental Immunology Branch, NCI, NIH, Bethesda, Maryland 20892, USA
    FASEB J 20:559-61. 2006
    ..These observations suggest a novel mechanism for the atherogenic properties of Lp(a)...