N Inoue

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi request reprint Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo
    J Katahira
    Department of Bacterial Toxinology, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565, Japan
    J Biol Chem 272:26652-8. 1997
  2. pmc Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2
    R Watanabe
    Department of Immunoregulation, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    EMBO J 19:4402-11. 2000
  3. ncbi request reprint Dissecting and manipulating the pathway for glycosylphos-phatidylinositol-anchor biosynthesis
    T Kinoshita
    Department of Immunoregulation, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, 565 0871, Osaka, Japan
    Curr Opin Chem Biol 4:632-8. 2000
  4. ncbi request reprint Requirement of PIG-F and PIG-O for transferring phosphoethanolamine to the third mannose in glycosylphosphatidylinositol
    Y Hong
    Department of Immunoregulation, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    J Biol Chem 275:20911-9. 2000
  5. pmc The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1
    R Watanabe
    Department of Immunoregulation, Research Institute for Microbial Diseases, Osaka University, Japan
    EMBO J 17:877-85. 1998
  6. pmc Molecular cloning and functional characterization of the receptor for Clostridium perfringens enterotoxin
    J Katahira
    Department of Bacterial Toxicology, Osaka University, Japan
    J Cell Biol 136:1239-47. 1997
  7. ncbi request reprint A homologue of Saccharomyces cerevisiae Dpm1p is not sufficient for synthesis of dolichol-phosphate-mannose in mammalian cells
    S Tomita
    Department of Immunoregulation, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    J Biol Chem 273:9249-54. 1998
  8. pmc PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8
    K Ohishi
    Department of Immunoregulation, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    EMBO J 20:4088-98. 2001
  9. ncbi request reprint Structures and chromosomal localizations of the glycosylphosphatidylinositol synthesis gene PIGC and its pseudogene PIGCP1
    Y Hong
    Department of Immunoregulation, Osaka University, Japan
    Genomics 44:347-9. 1997
  10. ncbi request reprint Human and mouse GPAA1 (Glycosylphosphatidylinositol anchor attachment 1) genes: genomic structures, chromosome loci and the presence of a minor class intron
    N Inoue
    Department of Immunoregulation, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    Cytogenet Cell Genet 84:199-205. 1999

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo
    J Katahira
    Department of Bacterial Toxinology, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka, Suita, Osaka 565, Japan
    J Biol Chem 272:26652-8. 1997
    ..These results indicate that CPE uses structurally related cellular proteins as functional receptors in vivo and that organs that have not so far been recognized as CPE-sensitive have the potential to be targets of CPE...
  2. pmc Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2
    R Watanabe
    Department of Immunoregulation, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    EMBO J 19:4402-11. 2000
    ..These results reveal new essential and regulatory components of GPI-GnT and imply co-regulation of GPI-GnT and the dolichol-phosphate-mannose synthase that generates a mannosyl donor for GPI...
  3. ncbi request reprint Dissecting and manipulating the pathway for glycosylphos-phatidylinositol-anchor biosynthesis
    T Kinoshita
    Department of Immunoregulation, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, 565 0871, Osaka, Japan
    Curr Opin Chem Biol 4:632-8. 2000
    ..These studies have revealed the common and also different characteristics of glycosylphosphatidyl-inositol biosynthesis enzymes in different organisms, leading to the development of species-specific inhibitors of the pathway...
  4. ncbi request reprint Requirement of PIG-F and PIG-O for transferring phosphoethanolamine to the third mannose in glycosylphosphatidylinositol
    Y Hong
    Department of Immunoregulation, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    J Biol Chem 275:20911-9. 2000
    ..Therefore, mammalian cells have redundant activities in transferring phosphoethanolamine to the third mannose, both of which require PIG-F...
  5. pmc The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1
    R Watanabe
    Department of Immunoregulation, Research Institute for Microbial Diseases, Osaka University, Japan
    EMBO J 17:877-85. 1998
    ..These results suggest that GPI-GnT recognizes the fatty acyl chains of PI. The unusually complex organization of GPI-GnT may be relevant to selective usage of PI and/or regulation...
  6. pmc Molecular cloning and functional characterization of the receptor for Clostridium perfringens enterotoxin
    J Katahira
    Department of Bacterial Toxicology, Osaka University, Japan
    J Cell Biol 136:1239-47. 1997
    ..From these results, it is proposed that the enterotoxin receptor is required for both target cell recognition and pore formation in the cell membrane...
  7. ncbi request reprint A homologue of Saccharomyces cerevisiae Dpm1p is not sufficient for synthesis of dolichol-phosphate-mannose in mammalian cells
    S Tomita
    Department of Immunoregulation, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    J Biol Chem 273:9249-54. 1998
    ..Therefore, in contrast to yeast, mammalian cells require hDPM1/mDPM1 protein and a product of another gene that is defective in Lec15 mutant cells for synthesis of Dol-P-Man...
  8. pmc PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8
    K Ohishi
    Department of Immunoregulation, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    EMBO J 20:4088-98. 2001
    ..Saccharomyces cerevisiae Gpi16p (YHR188C) and Gpi17p (YDR434W) are orthologues of PIG-T and PIG-S, respectively...
  9. ncbi request reprint Structures and chromosomal localizations of the glycosylphosphatidylinositol synthesis gene PIGC and its pseudogene PIGCP1
    Y Hong
    Department of Immunoregulation, Osaka University, Japan
    Genomics 44:347-9. 1997
    ..PIGC is an intronless gene. We found an intronless pseudogene of PIGC, PIGCP1, and mapped it to chromosome 11p12-p13. The presence of a processed pseudogene is a common feature of PIGA, PIGF, and PIGC...
  10. ncbi request reprint Human and mouse GPAA1 (Glycosylphosphatidylinositol anchor attachment 1) genes: genomic structures, chromosome loci and the presence of a minor class intron
    N Inoue
    Department of Immunoregulation, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    Cytogenet Cell Genet 84:199-205. 1999
    ..The mouse GPAA1 gene (Gpaa1) bearing AG at the 3' splice site prepared by site-directed mutagenesis was functional, indicating that any nucleotide is allowed at the 3' end of a minor class intron...
  11. pmc Gaa1p and gpi8p are components of a glycosylphosphatidylinositol (GPI) transamidase that mediates attachment of GPI to proteins
    K Ohishi
    Department of Immunoregulation, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Mol Biol Cell 11:1523-33. 2000
    ..Moreover, Gaa1p and Gpi8p are associated with each other. Therefore, Gaa1p and Gpi8p constitute a GPI transamidase and cooperate in generating a carbonyl intermediate, a prerequisite for GPI attachment...
  12. pmc PIG-B, a membrane protein of the endoplasmic reticulum with a large lumenal domain, is involved in transferring the third mannose of the GPI anchor
    M Takahashi
    Department of Immunoregulation, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
    EMBO J 15:4254-61. 1996
    ..This autosomal location would explain why PIG-B is not involved in the defective GPI anchor synthesis in paroxysmal nocturnal hemoglobinuria, which is always caused by a somatic mutation of the X-linked PIG-A gene...
  13. ncbi request reprint Expression cloning of PIG-L, a candidate N-acetylglucosaminyl-phosphatidylinositol deacetylase
    N Nakamura
    Department of Immunoregulation, Research Institute for Microbial Diseases, Osaka University, Osaka 565, Japan
    J Biol Chem 272:15834-40. 1997
    ..This orientation of PIG-L protein is consistent with the notion that the second step of GPI anchor biosynthesis occurs on the cytoplasmic side of the endoplasmic reticulum...
  14. pmc Bordetella bronchiseptica dermonecrotizing toxin induces reorganization of actin stress fibers through deamidation of Gln-63 of the GTP-binding protein Rho
    Y Horiguchi
    Department of Bacterial Toxicology, Research Institute for Microbial Diseases, Osaka University, 3 1, Yamada oka, Suita, Osaka 565, Japan
    Proc Natl Acad Sci U S A 94:11623-6. 1997
    ..These results indicate that the toxin catalyzes deamidation of Gln-63 of Rho and renders it constitutively active, leading to formation of actin stress fibers...
  15. ncbi request reprint PIG-A and PIG-H, which participate in glycosylphosphatidylinositol anchor biosynthesis, form a protein complex in the endoplasmic reticulum
    R Watanabe
    Department of Immunoregulation, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565, Japan
    J Biol Chem 271:26868-75. 1996
    ..Taken together with the cytoplasmic orientation of GlcNAc-PI, these results indicated that PIG-A and PIG-H are subunits of the GPI GlcNAc transferase that transfers GlcNAc to PI on the cytoplasmic side of the ER...
  16. ncbi request reprint PIG-C, one of the three human genes involved in the first step of glycosylphosphatidylinositol biosynthesis is a homologue of Saccharomyces cerevisiae GPI2
    N Inoue
    Department of Immunoregulation, Osaka University, Japan
    Biochem Biophys Res Commun 226:193-9. 1996
    ..Since there are several human EST sequences that have homology to GPI1, our results suggest that four genes are involved in the first step of GPI anchor synthesis in mammalian cells...
  17. pmc Association of functional GITR gene polymorphisms related to expression of glucocorticoid-induced tumour necrosis factor-receptor (GITR) molecules with prognosis of autoimmune thyroid disease
    R Tomizawa
    Department of Biomedical Informatics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Clin Exp Immunol 165:141-7. 2011
    ..In conclusion, the rs3753348 C/G SNP in the GITR is associated with HD prognosis and expression on T(reg) and T(eff) cells...
  18. ncbi request reprint Cloning and characterization of the murine GPI anchor synthesis gene Pigf, a homologue of the human PIGF gene
    K Ohishi
    Department of Immunoregulation, Research Institute for Microbial Diseases, Osaka University, Osaka, 565, Japan
    Genomics 34:340-6. 1996
    ..The results also extend a region in murine distal chromosome 17 that is syntenic to human chromosome 2p16-p22...
  19. ncbi request reprint Structure and chromosomal localization of the GPI-anchor synthesis gene PIGF and its pseudogene psi PIGF
    K Ohishi
    Department of Immunoregulation, Research Institute for Microbial Diseases, Osaka University, Japan
    Genomics 29:804-7. 1995
    ..We also identified the processed pseudogene of PIGF (psi PIGF) and mapped it to 5q35...
  20. ncbi request reprint Expression cloning of genes for GPI-anchor biosynthesis
    T Kinoshita
    Department of Immunoregulation, Osaka University, Japan
    Braz J Med Biol Res 27:127-32. 1994
    ..PIG-B cDNA restored the surface expression of Thy-1 on SIA-b cells and also synthesis of mature type GPI-anchor precursors in these cells.(ABSTRACT TRUNCATED AT 250 WORDS)..
  21. ncbi request reprint The cloning of PIG-A, a component in the early step of GPI-anchor biosynthesis
    T Miyata
    Department of Immunoregulation, Osaka University, Japan
    Science 259:1318-20. 1993
    ..PIG-A was necessary for synthesis of N-acetylglucosaminyl-phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis...
  22. ncbi request reprint Age-related decreases in the response of aquaporin-5 to acetylcholine in rat parotid glands
    N Inoue
    Department of Pharmacology, Tokushima University School of Dentistry, Kuramoto Cho, Tokushima 770 8504, Japan
    J Dent Res 82:476-80. 2003
    ..These results suggest that SNI-2011 might have therapeutic benefit for the treatment of age-related xerostomia...
  23. ncbi request reprint Three soluble form messages of murine CD46 are produced through alternative mRNA splicing
    A Tsujimura
    Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari-ku, Osaka 537-8511, Japan
    J Biochem 130:841-8. 2001
    ....
  24. ncbi request reprint Molecular cloning and functional characterization of chicken toll-like receptors. A single chicken toll covers multiple molecular patterns
    A Fukui
    Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Nakamichi, Higashinari ku, Osaka 537 8511, Japan
    J Biol Chem 276:47143-9. 2001
    ..In oviparous animals, the duplicated TLRs in the pattern-recognition system may function for host-pathogen discrimination in a manner that is distinct from that in mammals...
  25. ncbi request reprint Involvement of NADH/NADPH oxidase in human platelet ROS production
    T Seno
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
    Thromb Res 103:399-409. 2001
    ..Thus, human platelets have the enzymatic activity of p22(phox)-based NADH/NADPH oxidase, and this oxidase is likely one of the important sources of ROS in platelets...
  26. ncbi request reprint A 14-3-3 protein homologue is expressed in feline enteroepithelial-stages of Toxoplasma gondii
    T Koyama
    Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan
    Vet Parasitol 96:65-74. 2001
    ..These findings suggest that T. gondii parasites produce a protein showing partial homology with members of the 14-3-3 protein family and this protein is expressed in feline enteroepithelial-stages parasites...
  27. ncbi request reprint A novel chicken membrane-associated complement regulatory protein: molecular cloning and functional characterization
    N Inoue
    Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    J Immunol 166:424-31. 2001
    ..These results suggested that even in nonmammals a C regulatory membrane protein with ubiquitous tissue distribution should be a prerequisite for protection of host cells from homologous C attack...
  28. ncbi request reprint Characterization of genomic PIG-A gene: a gene for glycosylphosphatidylinositol-anchor biosynthesis and paroxysmal nocturnal hemoglobinuria
    Y Iida
    Department of Internal Medicine, Branch Hospital, Nagoya University School of Medicine, Japan
    Blood 83:3126-31. 1994
    ..We report pairs of oligonucleotide primers for polymerase chain reaction that should be useful to amplify and analyze various regions of the PIG-A gene in patients with PNH...
  29. pmc Transcription and initiation of ColE1 DNA replication in Escherichia coli K-12
    N Inoue
    Institute of Medical Science, University of Tokyo, Japan
    J Bacteriol 173:1208-14. 1991
    ....