Robert Benjamin Illing
Affiliation: University Hospital
Jakob T, Illing R, Rosskothen Kuhl N. Monaural Neonatal Deafness Induces Inhibition among Bilateral Auditory Networks under Binaural Activation. Neuroscience. 2018;: pubmed publisher
..These findings indicate changes in inhibitory interactions among neuronal networks as a result of monaural deafness. ..
Fredrich M, Zeber A, Hildebrandt H, Illing R. Differential molecular profiles of astrocytes in degeneration and re-innervation after sensory deafferentation of the adult rat cochlear nucleus. Eur J Neurosci. 2013;38:2041-56 pubmed publisher
Jakob T, DÃ¶ring U, Illing R. The pattern of Fos expression in the rat auditory brainstem changes with the temporal structure of binaural electrical intracochlear stimulation. Exp Neurol. 2015;266:55-67 pubmed publisher
..The differential response to synchronicity of the stimulation puts emphasis on the importance of the temporal structure of EIS with respect to its potential for changing brain structure and brain function in stimulus-specific ways. ..
Jakob T, Rosskothen Kuhl N, Illing R. Induction of single-sided deafness in the newborn rat and its consequence for cochlear nucleus volume development. Hear Res. 2016;333:210-215 pubmed publisher
..Thus, loss of sensory activation leads mainly, but not exclusively, to a reduction of tissue volume in the ventral CN of the deaf side, leaving the contralateral side apparently unaffected. ..
Illing R, Kraus K, Meidinger M. Reconnecting neuronal networks in the auditory brainstem following unilateral deafening. Hear Res. 2005;206:185-99 pubmed
Fredrich M, Illing R. MMP-2 is involved in synaptic remodeling after cochlear lesion. Neuroreport. 2010;21:324-7 pubmed publisher
..These results indicate a major role of MMP-2 in lesion-induced remodeling of central auditory networks and suggest a cooperativity with GAP-43-directed axonal outgrowth and synaptogenesis. ..
Rauch A, Rosskothen Kuhl N, Illing R. Counter-regulation of the AP-1 monomers pATF2 and Fos: Molecular readjustment of brainstem neurons in hearing and deaf adult rats after electrical intracochlear stimulation. Neuroscience. 2016;313:184-98 pubmed publisher
..This change in AP-1 constellation is expected to invoke different transcriptional cascades leading to distinct modes of tissue reorganization and plasticity responses in the mature central auditory system under stimulation. ..