Robert Benjamin Illing

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. pmc Deafferentation-induced redistribution of MMP-2, but not of MMP-9, depends on the emergence of GAP-43 positive axons in the adult rat cochlear nucleus
    Michaela Fredrich
    Neurobiological Research Laboratory, Department of Otorhinolaryngology, University of Freiburg, Killianst 5, D 79106 Freiburg, Germany
    Neural Plast 2011:859359. 2011
  2. pmc Synaptic reorganization in the adult rat's ventral cochlear nucleus following its total sensory deafferentation
    Heika Hildebrandt
    Neurobiological Research Laboratory, Department of Otorhinolaryngology, University of Freiburg, Freiburg, Germany
    PLoS ONE 6:e23686. 2011
  3. doi request reprint Differential molecular profiles of astrocytes in degeneration and re-innervation after sensory deafferentation of the adult rat cochlear nucleus
    Michaela Fredrich
    Neurobiological Research Laboratory, Department of Otorhinolaryngology, University of Freiburg, Killianst 5, Freiburg 79106, Germany
    Eur J Neurosci 38:2041-56. 2013
  4. doi request reprint MMP-2 is involved in synaptic remodeling after cochlear lesion
    Michaela Fredrich
    Neurobiological Research Laboratory, Department of Otorhinolaryngology, University of Freiburg, Freiburg, Germany
    Neuroreport 21:324-7. 2010
  5. ncbi request reprint Reconnecting neuronal networks in the auditory brainstem following unilateral deafening
    Robert Benjamin Illing
    Neurobiological Research Laboratory, Department of Otorhinolaryngology, University of Freiburg, D 79106 Freiburg, Germany
    Hear Res 206:185-99. 2005
  6. ncbi request reprint Specific plasticity responses to unilaterally decreased or increased hearing intensity in the adult cochlear nucleus and beyond
    Robert Benjamin Illing
    Neurobiological Research Laboratory, Department of Otorhinolaryngology, University of Freiburg, Killianstr 5, D 79106 Freiburg, Germany
    Hear Res 216:189-97. 2006
  7. ncbi request reprint Transcription factor modulation and expression in the rat auditory brainstem following electrical intracochlear stimulation
    Robert Benjamin Illing
    Neurobiological Research Laboratory, Department of Otorhinolaryngology, University of Freiburg, Killianstrasse 5, Freiburg, D 79106, Germany
    Exp Neurol 175:226-44. 2002
  8. ncbi request reprint Superior olivary contributions to auditory system plasticity: medial but not lateral olivocochlear neurons are the source of cochleotomy-induced GAP-43 expression in the ventral cochlear nucleus
    Kari Suzanne Kraus
    Neurobiological Research Laboratory, Department of Otorhinolaryngology, University of Freiburg, D 79106 Freiburg, Germany
    J Comp Neurol 475:374-90. 2004
  9. ncbi request reprint Immediate early gene expression invoked by electrical intracochlear stimulation in some but not all types of neurons in the rat auditory brainstem
    Adrian Reisch
    Neurobiological Research Laboratory, Killianstr 5, D 79106 Freiburg, Germany
    Exp Neurol 208:193-206. 2007
  10. ncbi request reprint Acoustic trauma induces reemergence of the growth- and plasticity-associated protein GAP-43 in the rat auditory brainstem
    Steffen A Michler
    Neurobiological Research Laboratory, Department of Otorhinolaryngology, University of Freiburg, D 79106 Freiburg, Germany
    J Comp Neurol 451:250-66. 2002

Collaborators

  • Nicole Rosskothen-Kuhl
  • Roland Laszig
  • Michaela Fredrich
  • Heika Hildebrandt
  • Adrian Reisch
  • Steffen A Michler
  • Nicole Rosskothen
  • Markus A Meidinger
  • Kari Suzanne Kraus
  • Anne C Zeber
  • Nadine A Hoffmann
  • Ingeborg Hirschm├╝ller-Ohmes
  • Heika Hildebrandt-Schoenfeld

Detail Information

Publications18

  1. pmc Deafferentation-induced redistribution of MMP-2, but not of MMP-9, depends on the emergence of GAP-43 positive axons in the adult rat cochlear nucleus
    Michaela Fredrich
    Neurobiological Research Laboratory, Department of Otorhinolaryngology, University of Freiburg, Killianst 5, D 79106 Freiburg, Germany
    Neural Plast 2011:859359. 2011
    ..In conclusion, GAP-43-containing axons emerging in AVCN after cochlear ablation seem to be causal for the maintenance of MMP-2-mediated ECM remodeling...
  2. pmc Synaptic reorganization in the adult rat's ventral cochlear nucleus following its total sensory deafferentation
    Heika Hildebrandt
    Neurobiological Research Laboratory, Department of Otorhinolaryngology, University of Freiburg, Freiburg, Germany
    PLoS ONE 6:e23686. 2011
    ..In conclusion, there appears to be a substantial potential for network reorganization and synaptogenesis in the auditory brainstem after loss of hearing, even in the adult brain...
  3. doi request reprint Differential molecular profiles of astrocytes in degeneration and re-innervation after sensory deafferentation of the adult rat cochlear nucleus
    Michaela Fredrich
    Neurobiological Research Laboratory, Department of Otorhinolaryngology, University of Freiburg, Killianst 5, Freiburg 79106, Germany
    Eur J Neurosci 38:2041-56. 2013
    ..In conclusion, re-innervation, including axonal growth and synaptogenesis, seems to prompt astrocytes to recompose their molecular profile, paving the way for tissue reorganisation after nerve degeneration and loss of synaptic contacts. ..
  4. doi request reprint MMP-2 is involved in synaptic remodeling after cochlear lesion
    Michaela Fredrich
    Neurobiological Research Laboratory, Department of Otorhinolaryngology, University of Freiburg, Freiburg, Germany
    Neuroreport 21:324-7. 2010
    ..These results indicate a major role of MMP-2 in lesion-induced remodeling of central auditory networks and suggest a cooperativity with GAP-43-directed axonal outgrowth and synaptogenesis...
  5. ncbi request reprint Reconnecting neuronal networks in the auditory brainstem following unilateral deafening
    Robert Benjamin Illing
    Neurobiological Research Laboratory, Department of Otorhinolaryngology, University of Freiburg, D 79106 Freiburg, Germany
    Hear Res 206:185-99. 2005
    ....
  6. ncbi request reprint Specific plasticity responses to unilaterally decreased or increased hearing intensity in the adult cochlear nucleus and beyond
    Robert Benjamin Illing
    Neurobiological Research Laboratory, Department of Otorhinolaryngology, University of Freiburg, Killianstr 5, D 79106 Freiburg, Germany
    Hear Res 216:189-97. 2006
    ..We tentatively suggest that after hearing loss or intracochlear stimulation responses of the central neural network in the adult brainstem suit the concept of functional adaptation...
  7. ncbi request reprint Transcription factor modulation and expression in the rat auditory brainstem following electrical intracochlear stimulation
    Robert Benjamin Illing
    Neurobiological Research Laboratory, Department of Otorhinolaryngology, University of Freiburg, Killianstrasse 5, Freiburg, D 79106, Germany
    Exp Neurol 175:226-44. 2002
    ....
  8. ncbi request reprint Superior olivary contributions to auditory system plasticity: medial but not lateral olivocochlear neurons are the source of cochleotomy-induced GAP-43 expression in the ventral cochlear nucleus
    Kari Suzanne Kraus
    Neurobiological Research Laboratory, Department of Otorhinolaryngology, University of Freiburg, D 79106 Freiburg, Germany
    J Comp Neurol 475:374-90. 2004
    ..We conclude that, after cochlear dysfunction, MOC neurons are the major (if not exclusive) source of synaptic reorganization in the VCN that could possibly entail compensatory activation of the affected ascending auditory pathway...
  9. ncbi request reprint Immediate early gene expression invoked by electrical intracochlear stimulation in some but not all types of neurons in the rat auditory brainstem
    Adrian Reisch
    Neurobiological Research Laboratory, Killianstr 5, D 79106 Freiburg, Germany
    Exp Neurol 208:193-206. 2007
    ..The pattern of IEG expression caused by unilateral EIS led us to suggest that dominant sensory activity may quickly initiate a facilitation of central pathways serving the active ear at the expense of those serving the unstimulated ear...
  10. ncbi request reprint Acoustic trauma induces reemergence of the growth- and plasticity-associated protein GAP-43 in the rat auditory brainstem
    Steffen A Michler
    Neurobiological Research Laboratory, Department of Otorhinolaryngology, University of Freiburg, D 79106 Freiburg, Germany
    J Comp Neurol 451:250-66. 2002
    ....
  11. doi request reprint The impact of hearing experience on signal integration in the auditory brainstem: a c-Fos study of the rat
    Nicole Rosskothen-Kuhl
    Neurobiological Research Laboratory, Department of Otorhinolaryngology, University of Freiburg, Killianst 5, D 79106 Freiburg, Germany
    Brain Res 1435:40-55. 2012
    ..When hearing fails, EIS entails expression of c-Fos in populations of neurons that are much larger than normally, essentially disregard tonotopic order, and lack much of spatio-temporal variations seen in hearing-experienced rats...
  12. ncbi request reprint Cochlear damage induces GAP-43 expression in cholinergic synapses of the cochlear nucleus in the adult rat: a light and electron microscopic study
    Markus A Meidinger
    Neurobiological Research Laboratory, Department of Otorhinolaryngology, University of Freiburg, D 79106 Freiburg, Germany
    Eur J Neurosci 23:3187-99. 2006
    ..We conclude that there is extensive deafness-induced GAP-43-mediated synaptic plasticity in the cochlear nucleus, and that this plasticity is predominantly, if not exclusively, based on cholinergic afferents...
  13. ncbi request reprint Molecular plasticity in the rat auditory brainstem: modulation of expression and distribution of phosphoserine, phospho-CREB and TrkB after noise trauma
    Steffen A Michler
    Neurobiological Research Laboratory, Department of Otorhinolaryngology, University of Freiburg, Freiburg, Germany
    Audiol Neurootol 8:190-206. 2003
    ....
  14. doi request reprint Nonlinear development of the populations of neurons expressing c-Fos under sustained electrical intracochlear stimulation in the rat auditory brainstem
    Nicole Rosskothen-Kuhl
    Neurobiological Research Laboratory, Department of Otorhinolaryngology, University of Freiburg, Killianst, 5, D 79106 Freiburg, Germany
    Brain Res 1347:33-41. 2010
    ..In conclusion, spatiotemporally varying recruitments of neuronal subpopulations into cellular networks responding to specific patterns of sensory activity take place in the auditory brainstem...
  15. doi request reprint Neuronal subtype identity in the rat auditory brainstem as defined by molecular profile and axonal projection
    Michaela Fredrich
    Neurobiological Research Laboratory, Department of Otorhinolaryngology, University of Freiburg, Freiburg, Germany
    Exp Brain Res 195:241-60. 2009
    ..Our data provide distinct extensions to previous characterizations of neuronal subtypes and reveal regularities and differences across auditory brainstem nuclei that are discussed for their functional implications...
  16. doi request reprint AP-1 activity rises by stimulation-dependent c-Fos expression in auditory neurons
    Nicole Rosskothen
    Neurobiological Research Laboratory, Department of Otorhinolaryngology, University of Freiburg, Freiburg, Germany
    Neuroreport 19:1091-3. 2008
    ..We conclude that stimulation triggers Fos-Jun dimerization, causing cascades of gene expression that potentially culminate in structural changes of neurons affected by the specific pattern of activity imposed on the neuronal system...
  17. ncbi request reprint The developmental dynamics of the brain is reflected by a regionally specific rise and fall of molecular complexity
    Robert Benjamin Illing
    Department of Otorhinolaryngology, University of Freiburg, Killianst 5, D 79106 Freiburg, Germany
    Eur J Neurosci 19:1417-20. 2004
    ..We conclude that the changing diversity of proteins may be used to identify landmarks in brain development...
  18. doi request reprint Gap43 transcription modulation in the adult brain depends on sensory activity and synaptic cooperation
    Nicole Rosskothen-Kuhl
    Neurobiological Research Laboratory, Department of Otorhinolaryngology, University of Freiburg, Freiburg, Germany
    PLoS ONE 9:e92624. 2014
    ..We suggest that as a function of input balance and activity pattern, Gap43 mRNA expression changes as cells associate converging afferent signals. ..