Marco Idzko

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. ncbi request reprint Attenuated allergic airway inflammation in Cd39 null mice
    M Idzko
    Department of Pneumology, University Medical Center, Freiburg, Germany
    Allergy 68:472-80. 2013
  2. pmc Chemotactic activity of extracellular nucleotideson human immune cells
    Daniel Myrtek
    Department of Pneumology, University Hospital Freiburg, Killianstrasse 5, 79106, Freiburg, Germany
    Purinergic Signal 3:5-11. 2007
  3. doi request reprint P2X7 receptor signaling in the pathogenesis of smoke-induced lung inflammation and emphysema
    Monica Lucattelli
    Department of Pulmonary Medicine, University of Freiburg, Germany
    Am J Respir Cell Mol Biol 44:423-9. 2011
  4. ncbi request reprint Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells
    Marco Idzko
    Department of Pulmonary Medicine, Erasmus University Medical Center, Dr Molewaterplein 50, P O Box 1738, 3000 DR Rotterdan, The Netherlands
    Nat Med 13:913-9. 2007
  5. doi request reprint A potential role for P2X7R in allergic airway inflammation in mice and humans
    Tobias Müller
    Department of Pneumology, University Medical Center Freiburg, Freiburg, Germany
    Am J Respir Cell Mol Biol 44:456-64. 2011
  6. ncbi request reprint Inosine stimulates chemotaxis, Ca2+-transients and actin polymerization in immature human dendritic cells via a pertussis toxin-sensitive mechanism independent of adenosine receptors
    Marco Idzko
    Department of Pneumology, University of Freiburg, Germany
    J Cell Physiol 199:149-56. 2004
  7. ncbi request reprint Lysophosphatidic acid induces chemotaxis, oxygen radical production, CD11b up-regulation, Ca2+ mobilization, and actin reorganization in human eosinophils via pertussis toxin-sensitive G proteins
    Marco Idzko
    Department of Pneumonology and Experimental Dermatology, University of Freiburg, Freiburg, Germany
    J Immunol 172:4480-5. 2004
  8. pmc 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo
    Tobias Müller
    Department of Pneumology, University Hospital Freiburg, Freiburg, Germany
    PLoS ONE 4:e6453. 2009
  9. pmc AMP affects intracellular Ca2+ signaling, migration, cytokine secretion and T cell priming capacity of dendritic cells
    Elisabeth Panther
    Department of Gastroenterology, University Medical Centre Freiburg, Freiburg, Germany
    PLoS ONE 7:e37560. 2012
  10. ncbi request reprint The serotoninergic receptors of human dendritic cells: identification and coupling to cytokine release
    Marco Idzko
    Department of Pneumology, University of Freiburg, Freiburg, Germany
    J Immunol 172:6011-9. 2004

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Attenuated allergic airway inflammation in Cd39 null mice
    M Idzko
    Department of Pneumology, University Medical Center, Freiburg, Germany
    Allergy 68:472-80. 2013
    ..In this study, we have evaluated the impact of Cd39 deletion and associated perturbation of purinergic signaling in AAI...
  2. pmc Chemotactic activity of extracellular nucleotideson human immune cells
    Daniel Myrtek
    Department of Pneumology, University Hospital Freiburg, Killianstrasse 5, 79106, Freiburg, Germany
    Purinergic Signal 3:5-11. 2007
    ..In this review, we summarise recent findings in this field and put forward a hypothesis on the role of P2 receptors in the early recruitment of human immune cells to the site of inflammation...
  3. doi request reprint P2X7 receptor signaling in the pathogenesis of smoke-induced lung inflammation and emphysema
    Monica Lucattelli
    Department of Pulmonary Medicine, University of Freiburg, Germany
    Am J Respir Cell Mol Biol 44:423-9. 2011
    ..Inhibition of this receptor may be a new therapeutic target for the treatment of chronic obstructive pulmonary disease...
  4. ncbi request reprint Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells
    Marco Idzko
    Department of Pulmonary Medicine, Erasmus University Medical Center, Dr Molewaterplein 50, P O Box 1738, 3000 DR Rotterdan, The Netherlands
    Nat Med 13:913-9. 2007
    ..Together these data show that purinergic signaling has a key role in allergen-driven lung inflammation that is likely to be amenable to therapeutic intervention...
  5. doi request reprint A potential role for P2X7R in allergic airway inflammation in mice and humans
    Tobias Müller
    Department of Pneumology, University Medical Center Freiburg, Freiburg, Germany
    Am J Respir Cell Mol Biol 44:456-64. 2011
    ..Our data suggest that targeting P2X₇R on hematopoietic cells (e.g., DCs or eosinophils) might be a new therapeutic option for the treatment of asthma...
  6. ncbi request reprint Inosine stimulates chemotaxis, Ca2+-transients and actin polymerization in immature human dendritic cells via a pertussis toxin-sensitive mechanism independent of adenosine receptors
    Marco Idzko
    Department of Pneumology, University of Freiburg, Germany
    J Cell Physiol 199:149-56. 2004
    ..In aggregate, our study indicates that inosine may be involved in the trafficking control system of immature DC, and mediates its chemotactic activity by a PTX-sensitive mechanism independent of adenosine receptors...
  7. ncbi request reprint Lysophosphatidic acid induces chemotaxis, oxygen radical production, CD11b up-regulation, Ca2+ mobilization, and actin reorganization in human eosinophils via pertussis toxin-sensitive G proteins
    Marco Idzko
    Department of Pneumonology and Experimental Dermatology, University of Freiburg, Freiburg, Germany
    J Immunol 172:4480-5. 2004
    ..These findings point to a novel role of LPA in the pathogenesis of diseases with eosinophilic inflammation such as atopic diseases as chemotaxin as well as activator of proinflammatory effector functions...
  8. pmc 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo
    Tobias Müller
    Department of Pneumology, University Hospital Freiburg, Freiburg, Germany
    PLoS ONE 4:e6453. 2009
    ..In summary, our study shows that 5-HT is a potent regulator of human dendritic cell function, and that targeting serotoninergic receptors might be a promising approach for the treatment of inflammatory disorders...
  9. pmc AMP affects intracellular Ca2+ signaling, migration, cytokine secretion and T cell priming capacity of dendritic cells
    Elisabeth Panther
    Department of Gastroenterology, University Medical Centre Freiburg, Freiburg, Germany
    PLoS ONE 7:e37560. 2012
    ..In summary our data show that AMP when present during maturation is a potent regulator of dendritic cell function and point out the role for AMP in the pathogenesis of inflammatory disorders...
  10. ncbi request reprint The serotoninergic receptors of human dendritic cells: identification and coupling to cytokine release
    Marco Idzko
    Department of Pneumology, University of Freiburg, Freiburg, Germany
    J Immunol 172:6011-9. 2004
    ..In summary, our study shows that 5-HT stimulated, in a maturation-dependent manner, different signaling pathways in DC. These data point to a role for 5-HT in regulating the immune response at peripheral sites...
  11. ncbi request reprint 5-Hydroxytryptamine modulates cytokine and chemokine production in LPS-primed human monocytes via stimulation of different 5-HTR subtypes
    Thorsten Dürk
    Department of Pneumology, University Medical Clinic, University of Freiburg, Germany
    Int Immunol 17:599-606. 2005
    ..Our results point to a new role for 5-HT in inflammation by modulating cytokine production in monocytes via activation of 5-HTR(3), 5-HTR(4) and 5-HTR(7) subtypes...
  12. ncbi request reprint Purinergic receptor inhibition prevents the development of smoke-induced lung injury and emphysema
    Sanja Cicko
    Department of Pulmonary Medicine, University Hospital, Freiburg, Germany
    J Immunol 185:688-97. 2010
    ..We demonstrate, for the first time, that endogenous ATP contributes to smoke-induced lung inflammation and then development of emphysema via activation of the purinergic receptor subtypes, such as P2Y(2)R...
  13. ncbi request reprint Characterization of the biological activities of uridine diphosphate in human dendritic cells: Influence on chemotaxis and CXCL8 release
    Marco Idzko
    Department of Pneumology, University of Freiburg, Germany
    J Cell Physiol 201:286-93. 2004
    ..Moreover, our study indicates that UDP stimulates different signaling pathways in immature and mature DC in order to favor the accumulation of immature DC and to augment the capacity to secrete CXCL8 in mature DC...
  14. pmc Inhaled iloprost suppresses the cardinal features of asthma via inhibition of airway dendritic cell function
    Marco Idzko
    Department of Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Clin Invest 117:464-72. 2007
    ..These data should pave the way for a clinical effectiveness study using inhaled iloprost for the treatment of asthma...
  15. ncbi request reprint Functional characterization of histamine receptor subtypes in a human bronchial epithelial cell line
    Tobias Müller
    Department of Pneumology, University of Freiburg, Freiburg, Germany
    Int J Mol Med 18:925-31. 2006
    ..In summary our data provide evidence that histamine released during allergic lung diseases exerts regulatory influence on airway epithelial cells...
  16. ncbi request reprint The P2Y14 receptor of airway epithelial cells: coupling to intracellular Ca2+ and IL-8 secretion
    Tobias Müller
    Department of Pneumology, University Medical Clinic, University of Freiburg, D 79104 Freiburg i Br, Germany
    Am J Respir Cell Mol Biol 33:601-9. 2005
    ..In addition, UDP-glc did not affect proliferation of the two cell lines. In summary, our data provide evidence for a distinct physiologic role of P2Y(14) in the selective release of specific chemokines from human airway epithelial cells...
  17. ncbi request reprint The influence of lysophosphatidic acid on the functions of human dendritic cells
    Elisabeth Panther
    Department of Experimental Dermatology, University of Freiburg, Hauptstrasse 7, D 79104 Freiburg i Br, Germany
    J Immunol 169:4129-35. 2002
    ..In summary, our study implicates that LPA might regulate the trafficking, cytokine production, and T cell-activating functions of DCs...
  18. ncbi request reprint Adenosine affects expression of membrane molecules, cytokine and chemokine release, and the T-cell stimulatory capacity of human dendritic cells
    Elisabeth Panther
    Department of Experimental Dermatology and Pneumology, University of Freiburg, Germany
    Blood 101:3985-90. 2003
    ..In aggregate, the results provide initial evidence that adenosine diminishes the capacity of DCs to initiate and amplify Th1 immune responses...
  19. doi request reprint Extracellular adenosine triphosphate and chronic obstructive pulmonary disease
    Marek Lommatzsch
    Department of Pneumology, University of Rostock, Rostock, Germany
    Am J Respir Crit Care Med 181:928-34. 2010
    ..Extracellular ATP promotes inflammation, but its role in chronic obstructive pulmonary disease (COPD) is unknown...
  20. pmc Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function
    Marco Idzko
    Department of Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Clin Invest 116:2935-44. 2006
    ..These data support the concept that targeting the function of airway DCs with locally acting drugs is a powerful new strategy in the treatment of asthma...
  21. ncbi request reprint Activation of human alveolar macrophages via P2 receptors: coupling to intracellular Ca2+ increases and cytokine secretion
    Daniel Myrtek
    University Hospital Freiburg, Department of Pneumology, Freiburg, Germany
    J Immunol 181:2181-8. 2008
    ..In summary, our data further support the hypothesis that purinoceptors are involved in the pathogenesis of inflammatory lung diseases...
  22. ncbi request reprint Nucleotides induce chemotaxis and actin polymerization in immature but not mature human dendritic cells via activation of pertussis toxin-sensitive P2y receptors
    Marco Idzko
    Department of Experimental Dermatology, University of Freiburg, Germany
    Blood 100:925-32. 2002
    ....
  23. doi request reprint Production of serotonin by tryptophan hydroxylase 1 and release via platelets contribute to allergic airway inflammation
    Thorsten Dürk
    Department of Pneumology, University Medical Center Freiburg, Freiburg, Germany
    Am J Respir Crit Care Med 187:476-85. 2013
    ..It is unclear, however, how 5-HT contributes to AAI and whether this depends on tryptophan hydroxylase (TPH) 1, the critical enzyme for peripheral 5-HT synthesis...
  24. ncbi request reprint Serotoninergic receptors on human airway epithelial cells
    Hans Bayer
    University Hospital Freiburg, Department of Pneumology, Hugstetterstrasse 55, D 79106 Freiburg i Br, Germany
    Am J Respir Cell Mol Biol 36:85-93. 2007
    ..In summary, our data implicate a pathophysiologic role of 5-HT in the asthmatic inflammatory responses in human airway epithelial cells...
  25. doi request reprint Purinergic receptor type 6 contributes to airway inflammation and remodeling in experimental allergic airway inflammation
    Rodolfo Paula Vieira
    University Hospital Freiburg, Department of Pneumology, Freiburg, Germany
    Am J Respir Crit Care Med 184:215-23. 2011
    ....
  26. pmc Expression of interleukin-13 receptor alpha 1-subunit on peripheral blood eosinophils is regulated by cytokines
    Daniel Myrtek
    Department of Pneumology, University Hospital Freiburg, Freiburg, Germany
    Immunology 112:597-604. 2004
    ..These findings suggest a regulatory cytokine network influencing the reactivity of eosinophils to IL-13...
  27. pmc Stimulation of P2 purinergic receptors induces the release of eosinophil cationic protein and interleukin-8 from human eosinophils
    Marco Idzko
    Department of Pneumology, University of Freiburg, D 79104 Freiburg i Br, Germany
    Br J Pharmacol 138:1244-50. 2003
    ....
  28. doi request reprint Purinergic P2Y₂ receptors promote neutrophil infiltration and hepatocyte death in mice with acute liver injury
    Cemil Korcan Ayata
    Department of Medicine V, University Hospital Freiburg, Freiburg, Germany
    Gastroenterology 143:1620-1629.e4. 2012
    ..Endogenous release of adenosine triphosphate (ATP) in the liver activates purinergic P2 receptors (P2R), which regulate inflammatory responses, but little is known about the roles of these processes in the development of acute hepatitis...
  29. ncbi request reprint Pasteurella multocida toxin (PMT) activates RhoGTPases, induces actin polymerization and inhibits migration of human dendritic cells, but does not influence macropinocytosis
    Dagmar Blöcker
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Freiburg, Germany
    Int Immunol 18:459-64. 2006
    ..In summary, these data indicate that PMT inhibits proper function of the motility machinery in DCs, which might limit the development of adaptive immune surveillance during infection with Pasteurella multocida...
  30. doi request reprint Graft-versus-host disease is enhanced by extracellular ATP activating P2X7R
    Konrad Wilhelm
    Department of Hematology and Oncology, Freiburg University Medical Center, Albert Ludwigs University, Freiburg, Germany
    Nat Med 16:1434-8. 2010
    ..These data have major implications for transplantation medicine, as pharmacological interference with danger signals that act via P2X(7)R could lead to the development of tolerance without the need for intensive immunosuppression...
  31. pmc Graft-versus-host disease reduces regulatory T-cell migration into the tumour tissue
    Christoph Dürr
    Department of Haematology and Oncology, Freiburg University Medical Centre, Albert Ludwigs University, Freiburg, Germany
    Immunology 137:80-8. 2012
    ..In conclusion, we demonstrate that GvHD-related inflammation reduced Treg-cell numbers at the tumour sites, which may in turn help to explain the observation that patients with GvHD have a lower risk of tumour relapse...
  32. ncbi request reprint Danger signals activating innate immunity in graft-versus-host disease
    Robert Zeiser
    Department of Hematology and Oncology, Freiburg University Medical Center, Albert Ludwigs University, Hugstetterstr 55, 79106 Freiburg, Germany
    J Mol Med (Berl) 89:833-45. 2011
    ..This review covers both the impact of endogenous and exogenous danger signals activating innate immunity in GvHD...
  33. ncbi request reprint Expression and function of histamine receptors in human monocyte-derived dendritic cells
    Marco Idzko
    Department of Experimental Dermatology, University Hospital, Freiburg, Germany
    J Allergy Clin Immunol 109:839-46. 2002
    ..Histamine is a well-known mediator eliciting different responses in immune and nonimmune cells, but its role in modulating dendritic cell (DC) functions has been marginally investigated...
  34. ncbi request reprint Epidemiology of staphylococcal scalded skin syndrome in Germany
    Maja Mockenhaupt
    Dokumentationszentrum schwerer Hautreaktionen dZh, Department of Dermatology, University of Freiburg, Freiburg, Germany
    J Invest Dermatol 124:700-3. 2005
    ..The mortality rate was much lower in children than in adults. Young age was the main risk factor, whereas immunosuppression and consumptive infectious disease were the detected risk factors in adults...
  35. ncbi request reprint Nucleotide signalling during inflammation
    Marco Idzko
    Department of Pneumology, Freiburg University Medical Center, Albert Ludwigs University, 79106 Freiburg, Germany
    Nature 509:310-7. 2014
    ....
  36. ncbi request reprint Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses
    Marco Idzko
    Department of Experimental Dermatology of Freiburg, D 79104 Freiburg, Germany
    FASEB J 16:625-7. 2002
    ..In summary, our study implicates that S1P might regulate the trafficking of DC and ultimately favor Th2 lymphocyte-dominated immunity...
  37. ncbi request reprint Alerting and tuning the immune response by extracellular nucleotides
    Andrea la Sala
    Immune Cell Interaction Unit, Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Leukoc Biol 73:339-43. 2003
    ..Chronic exposure to low-dose nucleotides can redirect cellular responses to prototypic activation stimuli, leading to suppressed inflammation and immune deviation...
  38. ncbi request reprint Distinct effects of sphingosine-1-phosphate, lysophosphatidic acid and histamine in human and mouse dendritic cells
    Andreas Renkl
    Department of Dermatology, University of Ulm, Germany
    Int J Mol Med 13:203-9. 2004
    ..These findings suggest that mouse models might underestimate the complex regulative network between mast cells, platelets and DC...
  39. ncbi request reprint Dendritic cells exposed to extracellular adenosine triphosphate acquire the migratory properties of mature cells and show a reduced capacity to attract type 1 T lymphocytes
    Andrea la Sala
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata, IRCCS, Rome, Italy
    Blood 99:1715-22. 2002
    ..Our data suggest that ATP provides a signal for enhanced lymph node localization of DCs but that it may, at the same time, diminish the capacity of DCs to amplify type 1 immune responses...
  40. ncbi request reprint IL-6 and IL-8 release is mediated via multiple signaling pathways after stimulating dendritic cells with lysophospholipids
    Devrim Oz-Arslan
    Department of Anatomy, University of Oslo, Norway
    J Leukoc Biol 80:287-97. 2006
    ....
  41. ncbi request reprint The P2X7 receptor: a key player in IL-1 processing and release
    Davide Ferrari
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Italy
    J Immunol 176:3877-83. 2006
    ....
  42. ncbi request reprint Activation of human eosinophils via P2 receptors: novel findings and future perspectives
    Davide Ferrari
    Department of Experimental and Diagnostic Medicine, Interdisciplinary Center for the Study of Inflammation, University of Ferrara, Ferrara, Italy
    J Leukoc Biol 79:7-15. 2006
    ..In this review, we will summarize recent developments in this field and put forward a hypothesis about the role of P2 receptors in pathophysiological conditions where eosinophils are major players...