Affiliation: University of Giessen
- Regional and age-dependent expression of the nitric oxide receptor, soluble guanylyl cyclase, in the human brainC Ibarra
Justus Liebig University, Rudolf Buchheim Institute for Pharmacology, Frankfurter Strasse 107, D 35392, Giessen, Germany
Brain Res 907:54-60. 2001..Our data suggest that sGCalpha1 and sGCbeta1 subunits are widely distributed in human brain, consistent with a major role in NO signaling. Moreover, the NO/cGMP pathway appears to be affected by ageing in the human brain...
- Phosphorylation of blood vessel vasodilator-stimulated phosphoprotein at serine 239 as a functional biochemical marker of endothelial nitric oxide/cyclic GMP signalingCésar Ibarra-Alvarado
Rudolf Buchheim Institute for Pharmacology, Justus Liebig University, Giessen, Germany
Mol Pharmacol 61:312-9. 2002..These data suggest that vascular P(Ser239)-VASP is primarily regulated by the NO/cGMP pathway and may thus serve as a biochemical marker for the activity state of this essential pathway in endothelial function...