Research Topics
| Roman HuberSummaryAffiliation: University of Freiburg Country: Germany Publications
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Detail Information
Publications
Oral silymarin for chronic hepatitis C - a retrospective analysis comparing three dose regimensR Huber
Center for Complementary Medicine, Department of Internal Medicine II, University Hospital Freiburg, Germany
Eur J Med Res 10:68-70. 2005..Silymarin therapy had no side effects. Silymarin at the doses used, does not improve elevated aminotransferases in patients with chronic hepatitis C...- Coping strategies and the request for a consultation on complementary and alternative medicine -- a cross-sectional survey of patients in a psychosomatic and three medical departments of a german university hospitalR Huber
Uni Zentrum Naturheilkunde, Universitätsklinik Freiburg i Br, Germany
Forsch Komplementarmed Klass Naturheilkd 11:207-11. 2004..To identify factors, predicting which patients of a large German university hospital request for a consultation on complementary and alternative medicine (CAM)... - DDB treatment of patients with chronic hepatitisRoman Huber
University Hospital Freiburg, Department of Medicine II, Freiburg, Germany
Hepatology 39:1732-3. 2004..In conclusion, the normalization of ALT during DDB treatment does not indicate therapeutic efficacy. In view of the wide use of DDB in patients with chronic liver diseases who participate in clinical studies DDB use should be excluded... - Effects of subtotal fasting on plasmatic coagulation, fibrinolytic status and platelet activation: a controlled pilot study in healthy subjectsRoman Huber
Department of Medicine II Gastroenterology, Hepatology, Endocrinology and Infectious Diseases, University Hospital Freiburg, Hugstetter Strasse 55, D 79106 Freiburg, Germany
Nutr Metab Cardiovasc Dis 15:212-8. 2005..The objective of this study was to determine whether a well-known method of 1-week subtotal fasting affects hemostasis in healthy subjects... - Effects of one week juice fasting on lipid metabolism: a cohort study in healthy subjectsR Huber
Ambulanz für Naturheilverfahren Abteilung Innere Medizin II, Universitatsklinik Freiburg
Forsch Komplementarmed Klass Naturheilkd 10:7-10. 2003..We investigated the effects of a popular modified juice fasting program on lipid metabolism... - Effects of a lectin- and a viscotoxin-rich mistletoe preparation on clinical and hematologic parameters: a placebo-controlled evaluation in healthy subjectsRoman Huber
Center for Complementary Medicine Department of Internal Medicine II, University Hospital Freiburg, Germany
J Altern Complement Med 8:857-66. 2002..and a lectin-poor but viscotoxin-rich (Iscador Pini [IP] Weleda Company) mistletoe preparation on clinical and hematologic parameters in healthy subjects... - [Oral enzyme therapy for chronic hepatitis C--a retrospective analysis]Roman Huber
Uni Zentrum Naturheilkunde Freiburg i Br, Deutschland
Forsch Komplementarmed Klass Naturheilkd 12:144-7. 2005..In our study, we investigated whether comparable effects can be found in daily practice in German patients... - [Frequency of the common cold in healthy subjects during exposure to a lectin-rich and a lectin-poor mistletoe preparation in a randomized, double-blind, placebo-controlled study]R Huber
Ambulanz für Naturheilverfahren Abteilung Innere Medizin II, Universitätsklinikum Freiburg i Br
Forsch Komplementarmed Klass Naturheilkd 8:354-8. 2001..Mistletoe preparations have immunomodulatory properties in vitro and in vivo. We wanted to investigate whether or not these properties have an effect on the frequency of the common cold in healthy subjects... - Effects of a mistletoe preparation with defined lectin content on chronic hepatitis C: an individually controlled cohort studyR Huber
Center for Complementary Medicien, Department of Internal Medicine II, University Hospital Freiburg, Germany
Eur J Med Res 6:399-405. 2001..A significant eosinophilia suggests that ML containing mistletoe preparations induce a T-helper 2 immune response... - [Clinical remission of an HLA B27-positive sacroiliitis on vegan diet]R Huber
Ambulanz für Naturheilverfahren und Umweltmedizin, Abteilung Innere Medizin II, Universitatsklinik Freiburg
Forsch Komplementarmed Klass Naturheilkd 8:228-31. 2001..5 mg and ibuprofen 400-800 mg and the analgetic tramadol 50-150 mg, but evening and night pain and morning stiffness persisted under this treatment... - Immunologic effects of mistletoe lectins: a placebo-controlled study in healthy subjectsRoman Huber
Center for Complementary Medicine, University Hospital Freiburg, Freiburg, Germany
J Soc Integr Oncol 4:3-7. 2006..This effect might be related to a stimulation of IL-5 and/or GM-CSF, which was demonstrated ex vivo in vitro. ML resulted in a temporary increase of the granulocyte count, which is probably related to an acute-phase reaction... 
In vitro antiallergic effects of aqueous fermented preparations from Citrus and Cydonia fruitsRoman Huber
Center for Complementary Medicine, Department of Environmental Health Sciences, University Medical Center Freiburg, Freiburg, Germany
Planta Med 78:334-40. 2012....- Pharmacokinetics of natural mistletoe lectins after subcutaneous injectionRoman Huber
Department of Environmental Health Sciences, University Hospital Freiburg, Breisacher Str 115B, 79106 Freiburg, Germany
Eur J Clin Pharmacol 66:889-97. 2010..This open-label, phase I, monocenter clinical trial was performed in order to describe the pharmacokinetics of nML... - Mistletoe treatment induces GM-CSF- and IL-5 production by PBMC and increases blood granulocyte- and eosinophil counts: a placebo controlled randomized study in healthy subjectsRoman Huber
Center for Complementary Medicine, University Hospital Freiburg, Breisacher Str 60, D 79106 Freiburg, Germany
Eur J Med Res 10:411-8. 2005.... - In vivo-induction of antibodies to mistletoe lectin-1 and viscotoxin by exposure to aqueous mistletoe extracts: a randomised double-blinded placebo controlled phase I study in healthy individualsR Klein
Department of Internal Medicine II, University of Tubingen, Germany
Eur J Med Res 7:155-63. 2002.... - In vitro cytotoxicity of cyclodextrin-bonded birch bark extractAnke Hertrampf
Center for Complementary Medicine, Department of Environmental Health Sciences, University Medical Center Freiburg, Freiburg, Germany
Planta Med 78:881-9. 2012..STE is far less toxic in hepatocytes. The anticancer potential of STE should be further characterised and also investigated in animal models... - Arnica and stinging nettle for treating burns - a self-experimentRoman Huber
Center for Complementary Medicine, Department of Environmental Health Sciences, University Hospital Freiburg, Germany
Complement Ther Med 19:276-80. 2011..Because clinical investigations are lacking we wanted to investigate its efficacy in partial thickness burns... - Experience and attitudes towards CAM--a survey of internal and psychosomatic patients in a German university hospitalRoman Huber
Center for Complementary Medicine, University Hospital, Freiburg, Germany
Altern Ther Health Med 10:32-6. 2004..22), desire to participate in therapeutic decisions (r = 0.29), motivation to change, if recommended, the life style (r = 0.31) and desire for a holistic treatment (r = 0.37)... - Artichoke leave extract for chronic hepatitis C - a pilot studyR Huber
Center for Complementary Medicine, University Hospital Freiburg, Freiburg, Germany
Phytomedicine 16:801-4. 2009..Artichoke leave extracts (ALE) have hepatoprotektive properties and are used by patients with chronic liver disease. Effects in patients with chronic hepatitis C are unclear... - Immunomodulatory properties of a lemon-quince preparation (Gencydo®) as an indicator of anti-allergic potencyCarsten Gründemann
Center for Complementary Medicine, Department of Environmental Health Sciences, University Medical Center Freiburg, Freiburg, Germany
Phytomedicine 18:760-8. 2011..Because there are no reports about the mode of action, we investigated the anti-allergic effects of this preparation in vitro by using cell lines and primary cells in various biological and immunological endpoints... - Randomized and double-blind studies--demands and reality as demonstrated by two examples of mistletoe researchM Rostock
Klinik für Tumorbiologie an der Albert Ludwigs Universität, Breisacher Strasse 117, D 79106 Freiburg i Br, Germany
Forsch Komplementarmed Klass Naturheilkd 11:18-22. 2004..CONCLUSION: This background elucidates the need for improving the methodology of non-randomized trials to obtain objective and reliable results even in these fields of clinical research... - Anticancer activity of a lectin-rich mistletoe extract injected intratumorally into human pancreatic cancer xenograftsM Rostock
Center for Complementary Medicine, Department of Gastroenterology, University Hospital Freiburg, Hugstetter Str 55, D 79106 Freiburg, Germany
Anticancer Res 25:1969-75. 2005..In single case observations, tumour remissions after intratumoral injections of mistletoe extracts have been described... - Hypereosinophilia induced by high-dose intratumoral and peritumoral mistletoe application to a patient with pancreatic carcinomaR Huber
Center for Complementary Medicine, Department of Gastroenterology, University of Freiburg, Germany
J Altern Complement Med 6:305-10. 2000..CONCLUSION: Before high-dose intratumoral and peritumoral treatment with a Viscum album L. extract containing mistletoe, lectin 1 can be associated with hypereosinophilia and strong production of TH1 as TH2 cytokines as well... - An aqueous birch leaf extract of Betula pendula inhibits the growth and cell division of inflammatory lymphocytesCarsten Gründemann
Center for Complementary Medicine, Department of Environmental Health Sciences, University Medical Centre Freiburg, Breisacher Strasse 115B, Freiburg, Germany
J Ethnopharmacol 136:444-51. 2011..Leaf extracts of Betula pendula have been traditionally used for the treatment of patients with rheumatoid arthritis (RA) or osteoarthritis... - Tormentil for active ulcerative colitis: an open-label, dose-escalating studyRoman Huber
Department for Internal Medicine II, University Hospital Freiburg, Germany
J Clin Gastroenterol 41:834-8. 2007..Tormentil extracts (TE) have antioxidative properties and are used as a complementary therapy for chronic inflammatory bowel disease. In individual patients with ulcerative colitis (UC) positive effects have been observed... 
Safety and effects of two mistletoe preparations on production of Interleukin-6 and other immune parameters - a placebo controlled clinical trial in healthy subjectsRoman Huber
Uni Zentrum Naturheilkunde, University Medical Center Freiburg, Germany
BMC Complement Altern Med 11:116. 2011..Since mistletoe preparations are suspected to induce production of potentially tumor promoting cytokines like interleukin (IL)-6, further studies on the immunological effects are of interest...- Do plant cyclotides have potential as immunosuppressant peptides?Carsten Gründemann
Center for Complementary Medicine, Department of Environmental Health Sciences, University Medical Center Freiburg, Breisacher Straße 115B, D 79111 Freiburg, Germany
J Nat Prod 75:167-74. 2012.... - Enhanced in vitro activation of immunocompetent cells in healthy individuals being subcutaneously 'vaccinated' with placebo (physiological saline)Reinhild Klein
Department of Internal Medicine II, University of Tuebingen, Otfried Muller Strasse 10, 72076 Tuebingen, Germany
Clin Immunol 126:322-31. 2008..Subcutaneous injection of placebo, therefore, enhances immunoreactivity. Psychological aspects, activation of the autonomous nerve system or local activation of mast cells or dendritic cells may be responsible for this phenomenon... 
Effects of abdominal hot compresses on indocyanine green elimination--a randomized cross over study in healthy subjectsRoman Huber
Department of Internal Medicine II, Freiburg University Hospital, Germany
BMC Gastroenterol 7:27. 2007..Hot compresses on the right upper abdomen are used as support for patients with liver diseases in Germany. The study was designed to determine, whether they affect hepatic blood flow...- Quality of life, immunomodulation and safety of adjuvant mistletoe treatment in patients with gastric carcinoma - a randomized, controlled pilot studyKab Choong Kim
Center for Complementary Medicine, University Medical Center Freiburg, Freiburg, Germany
BMC Complement Altern Med 12:172. 2012..abstract:.. - Effectiveness of subcutaneous injections of a cartilage preparation in osteoarthritis of the knee--a randomized, placebo controlled phase II studyRoman Huber
Department of Environmental Health Sciences, University Hospital Freiburg, Breisacher Str 115B, D 79106 Freiburg, Germany
Complement Ther Med 18:113-8. 2010..Outcome parameters were the Western Ontario and Mc. Masters University Arthritis Index (WOMAC) scores and the use of concomitant pain medication during a follow up period of 2 months... - In vitro immunoreactivity towards lectin-rich or viscotoxin-rich mistletoe (Viscum album L.) extracts Iscador applied to healthy individualsRoman Huber
Centre for Complementary Medicine Department of Internal Medicine II, University of Freiburg, Germany
Arzneimittelforschung 56:447-56. 2006..Intriguingly, also in individuals receiving placebo injections immunological alterations were detected during the observation period... - Effect of rosiglitazone treatment on plaque inflammation and collagen content in nondiabetic patients: data from a randomized placebo-controlled trialFranz Meisner
Department of Thoracic and Vascular Surgery, University of Ulm, Germany
Arterioscler Thromb Vasc Biol 26:845-50. 2006..CONCLUSIONS: Four weeks of treatment with rosiglitazone significantly reduces vascular inflammation in nondiabetic patients, leading to a more stable type of arteriosclerotic lesion... - Biochemical and histological effects of 26 weeks of glycyrrhizin treatment in chronic hepatitis C: a randomized phase II trialHans Orlent
Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, The Netherlands
J Hepatol 45:539-46. 2006..The observed ALT response did not translate in a significant histological improvement after 6 months treatment... - Erythropoietin in cerebrospinal fluid: age-related reference values and relevance in neurological diseaseKarin Widl
Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany
Neurochem Res 32:1163-8. 2007..The establishment of age-related reference values in a large cohort of controls will improve the interpretation of future CSF EPO evaluations in neurological diseases... - Spatial navigation in complex and radial mazes in APP23 animals and neurotrophin signaling as a biological marker of early impairmentRainer Hellweg
Department of Psychiatry, , 14050 Berlin, Germany
Learn Mem 13:63-71. 2006..NGF and BDNF levels on maze learning are different in wild-type and transgenic animals, indicating that biological markers of AD may be altered on challenge even though equilibrium levels are alike...