Roman Huber

Summary

Affiliation: University of Freiburg
Country: Germany

Publications

  1. ncbi request reprint Effects of subtotal fasting on plasmatic coagulation, fibrinolytic status and platelet activation: a controlled pilot study in healthy subjects
    Roman Huber
    Department of Medicine II Gastroenterology, Hepatology, Endocrinology and Infectious Diseases, University Hospital Freiburg, Hugstetter Strasse 55, D 79106 Freiburg, Germany
    Nutr Metab Cardiovasc Dis 15:212-8. 2005
  2. ncbi request reprint [Oral enzyme therapy for chronic hepatitis C--a retrospective analysis]
    Roman Huber
    Uni Zentrum Naturheilkunde Freiburg i Br, Deutschland
    Forsch Komplementarmed Klass Naturheilkd 12:144-7. 2005
  3. ncbi request reprint Oral silymarin for chronic hepatitis C - a retrospective analysis comparing three dose regimens
    R Huber
    Center for Complementary Medicine, Department of Internal Medicine II, University Hospital Freiburg, Germany
    Eur J Med Res 10:68-70. 2005
  4. ncbi request reprint Coping strategies and the request for a consultation on complementary and alternative medicine -- a cross-sectional survey of patients in a psychosomatic and three medical departments of a german university hospital
    R Huber
    Uni Zentrum Naturheilkunde, Universitätsklinik Freiburg i Br, Germany
    Forsch Komplementarmed Klass Naturheilkd 11:207-11. 2004
  5. ncbi request reprint DDB treatment of patients with chronic hepatitis
    Roman Huber
    University Hospital Freiburg, Department of Medicine II, Freiburg, Germany
    Hepatology 39:1732-3. 2004
  6. ncbi request reprint Effects of one week juice fasting on lipid metabolism: a cohort study in healthy subjects
    R Huber
    Ambulanz für Naturheilverfahren Abteilung Innere Medizin II, Universitatsklinik Freiburg
    Forsch Komplementarmed Klass Naturheilkd 10:7-10. 2003
  7. ncbi request reprint Effects of a lectin- and a viscotoxin-rich mistletoe preparation on clinical and hematologic parameters: a placebo-controlled evaluation in healthy subjects
    Roman Huber
    Center for Complementary Medicine Department of Internal Medicine II, University Hospital Freiburg, Germany
    J Altern Complement Med 8:857-66. 2002
  8. ncbi request reprint [Clinical remission of an HLA B27-positive sacroiliitis on vegan diet]
    R Huber
    Ambulanz für Naturheilverfahren und Umweltmedizin, Abteilung Innere Medizin II, Universitatsklinik Freiburg
    Forsch Komplementarmed Klass Naturheilkd 8:228-31. 2001
  9. ncbi request reprint [Frequency of the common cold in healthy subjects during exposure to a lectin-rich and a lectin-poor mistletoe preparation in a randomized, double-blind, placebo-controlled study]
    R Huber
    Ambulanz für Naturheilverfahren Abteilung Innere Medizin II, Universitätsklinikum Freiburg i Br
    Forsch Komplementarmed Klass Naturheilkd 8:354-8. 2001
  10. ncbi request reprint Effects of a mistletoe preparation with defined lectin content on chronic hepatitis C: an individually controlled cohort study
    R Huber
    Center for Complementary Medicien, Department of Internal Medicine II, University Hospital Freiburg, Germany
    Eur J Med Res 6:399-405. 2001

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Effects of subtotal fasting on plasmatic coagulation, fibrinolytic status and platelet activation: a controlled pilot study in healthy subjects
    Roman Huber
    Department of Medicine II Gastroenterology, Hepatology, Endocrinology and Infectious Diseases, University Hospital Freiburg, Hugstetter Strasse 55, D 79106 Freiburg, Germany
    Nutr Metab Cardiovasc Dis 15:212-8. 2005
    ..The objective of this study was to determine whether a well-known method of 1-week subtotal fasting affects hemostasis in healthy subjects...
  2. ncbi request reprint [Oral enzyme therapy for chronic hepatitis C--a retrospective analysis]
    Roman Huber
    Uni Zentrum Naturheilkunde Freiburg i Br, Deutschland
    Forsch Komplementarmed Klass Naturheilkd 12:144-7. 2005
    ..In our study, we investigated whether comparable effects can be found in daily practice in German patients...
  3. ncbi request reprint Oral silymarin for chronic hepatitis C - a retrospective analysis comparing three dose regimens
    R Huber
    Center for Complementary Medicine, Department of Internal Medicine II, University Hospital Freiburg, Germany
    Eur J Med Res 10:68-70. 2005
    ..Silymarin therapy had no side effects. Silymarin at the doses used, does not improve elevated aminotransferases in patients with chronic hepatitis C...
  4. ncbi request reprint Coping strategies and the request for a consultation on complementary and alternative medicine -- a cross-sectional survey of patients in a psychosomatic and three medical departments of a german university hospital
    R Huber
    Uni Zentrum Naturheilkunde, Universitätsklinik Freiburg i Br, Germany
    Forsch Komplementarmed Klass Naturheilkd 11:207-11. 2004
    ..To identify factors, predicting which patients of a large German university hospital request for a consultation on complementary and alternative medicine (CAM)...
  5. ncbi request reprint DDB treatment of patients with chronic hepatitis
    Roman Huber
    University Hospital Freiburg, Department of Medicine II, Freiburg, Germany
    Hepatology 39:1732-3. 2004
    ..In conclusion, the normalization of ALT during DDB treatment does not indicate therapeutic efficacy. In view of the wide use of DDB in patients with chronic liver diseases who participate in clinical studies DDB use should be excluded...
  6. ncbi request reprint Effects of one week juice fasting on lipid metabolism: a cohort study in healthy subjects
    R Huber
    Ambulanz für Naturheilverfahren Abteilung Innere Medizin II, Universitatsklinik Freiburg
    Forsch Komplementarmed Klass Naturheilkd 10:7-10. 2003
    ..We investigated the effects of a popular modified juice fasting program on lipid metabolism...
  7. ncbi request reprint Effects of a lectin- and a viscotoxin-rich mistletoe preparation on clinical and hematologic parameters: a placebo-controlled evaluation in healthy subjects
    Roman Huber
    Center for Complementary Medicine Department of Internal Medicine II, University Hospital Freiburg, Germany
    J Altern Complement Med 8:857-66. 2002
    ..and a lectin-poor but viscotoxin-rich (Iscador Pini [IP] Weleda Company) mistletoe preparation on clinical and hematologic parameters in healthy subjects...
  8. ncbi request reprint [Clinical remission of an HLA B27-positive sacroiliitis on vegan diet]
    R Huber
    Ambulanz für Naturheilverfahren und Umweltmedizin, Abteilung Innere Medizin II, Universitatsklinik Freiburg
    Forsch Komplementarmed Klass Naturheilkd 8:228-31. 2001
    ..Positive effects of fasting and vegan diet in patients with rheumatic diseases are reported in the literature...
  9. ncbi request reprint [Frequency of the common cold in healthy subjects during exposure to a lectin-rich and a lectin-poor mistletoe preparation in a randomized, double-blind, placebo-controlled study]
    R Huber
    Ambulanz für Naturheilverfahren Abteilung Innere Medizin II, Universitätsklinikum Freiburg i Br
    Forsch Komplementarmed Klass Naturheilkd 8:354-8. 2001
    ..Mistletoe preparations have immunomodulatory properties in vitro and in vivo. We wanted to investigate whether or not these properties have an effect on the frequency of the common cold in healthy subjects...
  10. ncbi request reprint Effects of a mistletoe preparation with defined lectin content on chronic hepatitis C: an individually controlled cohort study
    R Huber
    Center for Complementary Medicien, Department of Internal Medicine II, University Hospital Freiburg, Germany
    Eur J Med Res 6:399-405. 2001
    ..A significant eosinophilia suggests that ML containing mistletoe preparations induce a T-helper 2 immune response...
  11. ncbi request reprint Immunologic effects of mistletoe lectins: a placebo-controlled study in healthy subjects
    Roman Huber
    Center for Complementary Medicine, University Hospital Freiburg, Freiburg, Germany
    J Soc Integr Oncol 4:3-7. 2006
    ..This effect might be related to a stimulation of IL-5 and/or GM-CSF, which was demonstrated ex vivo in vitro. ML resulted in a temporary increase of the granulocyte count, which is probably related to an acute-phase reaction...
  12. doi request reprint In vitro antiallergic effects of aqueous fermented preparations from Citrus and Cydonia fruits
    Roman Huber
    Center for Complementary Medicine, Department of Environmental Health Sciences, University Medical Center Freiburg, Freiburg, Germany
    Planta Med 78:334-40. 2012
    ....
  13. doi request reprint Pharmacokinetics of natural mistletoe lectins after subcutaneous injection
    Roman Huber
    Department of Environmental Health Sciences, University Hospital Freiburg, Breisacher Str 115B, 79106 Freiburg, Germany
    Eur J Clin Pharmacol 66:889-97. 2010
    ..This open-label, phase I, monocenter clinical trial was performed in order to describe the pharmacokinetics of nML...
  14. doi request reprint Traditionally used Veronica officinalis inhibits proinflammatory mediators via the NF-κB signalling pathway in a human lung cell line
    Carsten Gründemann
    Center for Complementary Medicine, Department of Environmental Health Sciences, University Medical Center Freiburg, Breisacher Str 115B, 79111 Freiburg, Germany
    J Ethnopharmacol 145:118-26. 2013
    ..Extracts from Veronica officinalis L. are traditionally used for the treatment of lung diseases; however, the effective compounds and the mode of action are still unknown...
  15. ncbi request reprint Mistletoe treatment induces GM-CSF- and IL-5 production by PBMC and increases blood granulocyte- and eosinophil counts: a placebo controlled randomized study in healthy subjects
    Roman Huber
    Center for Complementary Medicine, University Hospital Freiburg, Breisacher Str 60, D 79106 Freiburg, Germany
    Eur J Med Res 10:411-8. 2005
    ....
  16. ncbi request reprint In vivo-induction of antibodies to mistletoe lectin-1 and viscotoxin by exposure to aqueous mistletoe extracts: a randomised double-blinded placebo controlled phase I study in healthy individuals
    R Klein
    Department of Internal Medicine II, University of Tubingen, Germany
    Eur J Med Res 7:155-63. 2002
    ....
  17. doi request reprint In vitro cytotoxicity of cyclodextrin-bonded birch bark extract
    Anke Hertrampf
    Center for Complementary Medicine, Department of Environmental Health Sciences, University Medical Center Freiburg, Freiburg, Germany
    Planta Med 78:881-9. 2012
    ..STE is far less toxic in hepatocytes. The anticancer potential of STE should be further characterised and also investigated in animal models...
  18. doi request reprint Arnica and stinging nettle for treating burns - a self-experiment
    Roman Huber
    Center for Complementary Medicine, Department of Environmental Health Sciences, University Hospital Freiburg, Germany
    Complement Ther Med 19:276-80. 2011
    ..Because clinical investigations are lacking we wanted to investigate its efficacy in partial thickness burns...
  19. ncbi request reprint Experience and attitudes towards CAM--a survey of internal and psychosomatic patients in a German university hospital
    Roman Huber
    Center for Complementary Medicine, University Hospital, Freiburg, Germany
    Altern Ther Health Med 10:32-6. 2004
    ..22), desire to participate in therapeutic decisions (r = 0.29), motivation to change, if recommended, the life style (r = 0.31) and desire for a holistic treatment (r = 0.37)...
  20. ncbi request reprint Artichoke leave extract for chronic hepatitis C - a pilot study
    R Huber
    Center for Complementary Medicine, University Hospital Freiburg, Freiburg, Germany
    Phytomedicine 16:801-4. 2009
    ..Artichoke leave extracts (ALE) have hepatoprotektive properties and are used by patients with chronic liver disease. Effects in patients with chronic hepatitis C are unclear...
  21. doi request reprint Immunomodulatory properties of a lemon-quince preparation (Gencydo®) as an indicator of anti-allergic potency
    Carsten Gründemann
    Center for Complementary Medicine, Department of Environmental Health Sciences, University Medical Center Freiburg, Freiburg, Germany
    Phytomedicine 18:760-8. 2011
    ..Because there are no reports about the mode of action, we investigated the anti-allergic effects of this preparation in vitro by using cell lines and primary cells in various biological and immunological endpoints...
  22. ncbi request reprint Anticancer activity of a lectin-rich mistletoe extract injected intratumorally into human pancreatic cancer xenografts
    M Rostock
    Center for Complementary Medicine, Department of Gastroenterology, University Hospital Freiburg, Hugstetter Str 55, D 79106 Freiburg, Germany
    Anticancer Res 25:1969-75. 2005
    ..In single case observations, tumour remissions after intratumoral injections of mistletoe extracts have been described...
  23. ncbi request reprint Randomized and double-blind studies--demands and reality as demonstrated by two examples of mistletoe research
    M Rostock
    Klinik für Tumorbiologie an der Albert Ludwigs Universität, Breisacher Strasse 117, D 79106 Freiburg i Br, Germany
    Forsch Komplementarmed Klass Naturheilkd 11:18-22. 2004
    ..Faced with a life-threatening disease they wish to determine this part of their treatment themselves...
  24. ncbi request reprint Hypereosinophilia induced by high-dose intratumoral and peritumoral mistletoe application to a patient with pancreatic carcinoma
    R Huber
    Center for Complementary Medicine, Department of Gastroenterology, University of Freiburg, Germany
    J Altern Complement Med 6:305-10. 2000
    ..It is, however, still an open question whether this transient benefit was due to the induction of eosinophilia by a type-2 response...
  25. pmc Preclinical evaluation of 4-methylthiobutyl isothiocyanate on liver cancer and cancer stem cells with different p53 status
    Evelyn Lamy
    Department of Environmental Health Sciences, Freiburg University Medical Center, Freiburg, Germany
    PLoS ONE 8:e70846. 2013
    ..Our study could serve for a better understanding of the chemotherapeutic properties of isothiocyanates on human liver-derived cancer cells. ..
  26. ncbi request reprint Tormentil for active ulcerative colitis: an open-label, dose-escalating study
    Roman Huber
    Department for Internal Medicine II, University Hospital Freiburg, Germany
    J Clin Gastroenterol 41:834-8. 2007
    ..Tormentil extracts (TE) have antioxidative properties and are used as a complementary therapy for chronic inflammatory bowel disease. In individual patients with ulcerative colitis (UC) positive effects have been observed...
  27. doi request reprint An aqueous birch leaf extract of Betula pendula inhibits the growth and cell division of inflammatory lymphocytes
    Carsten Gründemann
    Center for Complementary Medicine, Department of Environmental Health Sciences, University Medical Centre Freiburg, Breisacher Strasse 115B, Freiburg, Germany
    J Ethnopharmacol 136:444-51. 2011
    ..Leaf extracts of Betula pendula have been traditionally used for the treatment of patients with rheumatoid arthritis (RA) or osteoarthritis...
  28. pmc Safety and effects of two mistletoe preparations on production of Interleukin-6 and other immune parameters - a placebo controlled clinical trial in healthy subjects
    Roman Huber
    Uni Zentrum Naturheilkunde, University Medical Center Freiburg, Germany
    BMC Complement Altern Med 11:116. 2011
    ..Since mistletoe preparations are suspected to induce production of potentially tumor promoting cytokines like interleukin (IL)-6, further studies on the immunological effects are of interest...
  29. pmc Do plant cyclotides have potential as immunosuppressant peptides?
    Carsten Gründemann
    Center for Complementary Medicine, Department of Environmental Health Sciences, University Medical Center Freiburg, Breisacher Straße 115B, D 79111 Freiburg, Germany
    J Nat Prod 75:167-74. 2012
    ....
  30. ncbi request reprint Enhanced in vitro activation of immunocompetent cells in healthy individuals being subcutaneously 'vaccinated' with placebo (physiological saline)
    Reinhild Klein
    Department of Internal Medicine II, University of Tuebingen, Otfried Muller Strasse 10, 72076 Tuebingen, Germany
    Clin Immunol 126:322-31. 2008
    ..Subcutaneous injection of placebo, therefore, enhances immunoreactivity. Psychological aspects, activation of the autonomous nerve system or local activation of mast cells or dendritic cells may be responsible for this phenomenon...
  31. pmc Effects of abdominal hot compresses on indocyanine green elimination--a randomized cross over study in healthy subjects
    Roman Huber
    Department of Internal Medicine II, Freiburg University Hospital, Germany
    BMC Gastroenterol 7:27. 2007
    ..Hot compresses on the right upper abdomen are used as support for patients with liver diseases in Germany. The study was designed to determine, whether they affect hepatic blood flow...
  32. pmc Quality of life, immunomodulation and safety of adjuvant mistletoe treatment in patients with gastric carcinoma - a randomized, controlled pilot study
    Kab Choong Kim
    Division of Stomach surgery, Department of Surgery, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea
    BMC Complement Altern Med 12:172. 2012
    ..Mistletoe (Viscum album L.) extracts are widely used in complementary cancer therapy. Aim of this study was to evaluate safety and efficacy of a standardized mistletoe extract (abnobaVISCUM(®) Quercus, aVQ) in patients with gastric cancer...
  33. doi request reprint Effectiveness of subcutaneous injections of a cartilage preparation in osteoarthritis of the knee--a randomized, placebo controlled phase II study
    Roman Huber
    Department of Environmental Health Sciences, University Hospital Freiburg, Breisacher Str 115B, D 79106 Freiburg, Germany
    Complement Ther Med 18:113-8. 2010
    ..Outcome parameters were the Western Ontario and Mc. Masters University Arthritis Index (WOMAC) scores and the use of concomitant pain medication during a follow up period of 2 months...
  34. ncbi request reprint In vitro immunoreactivity towards lectin-rich or viscotoxin-rich mistletoe (Viscum album L.) extracts Iscador applied to healthy individuals
    Roman Huber
    Centre for Complementary Medicine Department of Internal Medicine II, University of Freiburg, Germany
    Arzneimittelforschung 56:447-56. 2006
    ..Intriguingly, also in individuals receiving placebo injections immunological alterations were detected during the observation period...
  35. ncbi request reprint Erythropoietin in cerebrospinal fluid: age-related reference values and relevance in neurological disease
    Karin Widl
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany
    Neurochem Res 32:1163-8. 2007
    ..The establishment of age-related reference values in a large cohort of controls will improve the interpretation of future CSF EPO evaluations in neurological diseases...
  36. pmc Spatial navigation in complex and radial mazes in APP23 animals and neurotrophin signaling as a biological marker of early impairment
    Rainer Hellweg
    Department of Psychiatry, Charite University, 14050 Berlin, Germany
    Learn Mem 13:63-71. 2006
    ..NGF and BDNF levels on maze learning are different in wild-type and transgenic animals, indicating that biological markers of AD may be altered on challenge even though equilibrium levels are alike...
  37. ncbi request reprint Effect of rosiglitazone treatment on plaque inflammation and collagen content in nondiabetic patients: data from a randomized placebo-controlled trial
    Franz Meisner
    Department of Thoracic and Vascular Surgery, University of Ulm, Germany
    Arterioscler Thromb Vasc Biol 26:845-50. 2006
    ....
  38. ncbi request reprint Biochemical and histological effects of 26 weeks of glycyrrhizin treatment in chronic hepatitis C: a randomized phase II trial
    Hans Orlent
    Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, The Netherlands
    J Hepatol 45:539-46. 2006
    ..Our aim was to determine the dose frequency of glycyrrhizin required to maintain the ALT response beyond 4 weeks and evaluate its effect on liver histology and quality of life...