Siegfried Hoyer

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi Brain glucose and energy metabolism abnormalities in sporadic Alzheimer disease. Causes and consequences: an update
    S Hoyer
    Department of Pathochemistry and General Neurochemistry, University of Heidelberg, Im Neuenheimer Feld 220 221, 69120, Heidelberg, Germany
    Exp Gerontol 35:1363-72. 2000
  2. doi Long-term effects of corticosterone on behavior, oxidative and energy metabolism of parietotemporal cerebral cortex and hippocampus of rats: comparison to intracerebroventricular streptozotocin
    Siegfried Hoyer
    Department of Pathology, University of Heidelberg, Im Neuenheimer Feld 220 221, 69120 Heidelberg, Germany
    J Neural Transm 115:1241-9. 2008
  3. ncbi Glucose metabolism and insulin receptor signal transduction in Alzheimer disease
    Siegfried Hoyer
    Department of Pathology, University of Heidelberg, Im Neuenheimer Feld 220 221, 69120 Heidelberg, Germany
    Eur J Pharmacol 490:115-25. 2004
  4. ncbi Relationship between cerebral energy metabolism in parietotemporal cortex and hippocampus and mental activity during aging in rats
    S Hoyer
    Department of Pathology, University of Heidelberg, Heidelberg, Germany
    J Neural Transm 111:575-89. 2004
  5. ncbi The aging brain. Changes in the neuronal insulin/insulin receptor signal transduction cascade trigger late-onset sporadic Alzheimer disease (SAD). A mini-review
    Siegfried Hoyer
    Department of Pathochemistry and General Neurochemistry, Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220 221, D 69120 Heidelberg, Federal Republic of Germany
    J Neural Transm 109:991-1002. 2002
  6. ncbi Inhibition of the neuronal insulin receptor. An in vivo model for sporadic Alzheimer disease?
    S Hoyer
    Department of Pathochemistry and General Neurochemistry, University of Heidelberg, Im Neuenheimer Feld 220 221, D 69120 Heidelberg, Germany
    Ann N Y Acad Sci 920:256-8. 2000
  7. doi Insulin-resistant brain state after intracerebroventricular streptozotocin injection exacerbates Alzheimer-like changes in Tg2576 AbetaPP-overexpressing mice
    Konstanze Plaschke
    Clinic of Anesthesiology, University of Heidelberg Medical School, Heidelberg, Germany
    J Alzheimers Dis 19:691-704. 2010
  8. doi Insulin-resistant brain state (IRBS) changes membrane composition of fatty acids in temporal and entorhinal brain cortices of rats: relevance to sporadic Alzheimer's disease?
    Konstanze Plaschke
    Department of Anesthesiology, Experimental Anesthesiology, Medical Faculty of the University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    J Neural Transm 117:1419-22. 2010
  9. ncbi Causes and consequences of disturbances of cerebral glucose metabolism in sporadic Alzheimer disease: therapeutic implications
    Siegfried Hoyer
    Department of Pathochemistry and General Neurochemistry, University of Heidelberg, Im Neuenheimer Feld 220 221, Heidelberg, Germany 69120
    Adv Exp Med Biol 541:135-52. 2004
  10. ncbi Alzheimer disease--no target for statin treatment. A mini review
    Siegfried Hoyer
    Department of Pathology, University of Heidelberg, Im Neuenheimer Feld 220 221, D 69120 Heidelberg, Germany
    Neurochem Res 32:695-706. 2007

Collaborators

Detail Information

Publications18

  1. ncbi Brain glucose and energy metabolism abnormalities in sporadic Alzheimer disease. Causes and consequences: an update
    S Hoyer
    Department of Pathochemistry and General Neurochemistry, University of Heidelberg, Im Neuenheimer Feld 220 221, 69120, Heidelberg, Germany
    Exp Gerontol 35:1363-72. 2000
    ....
  2. doi Long-term effects of corticosterone on behavior, oxidative and energy metabolism of parietotemporal cerebral cortex and hippocampus of rats: comparison to intracerebroventricular streptozotocin
    Siegfried Hoyer
    Department of Pathology, University of Heidelberg, Im Neuenheimer Feld 220 221, 69120 Heidelberg, Germany
    J Neural Transm 115:1241-9. 2008
    ..However, further studies are needed on the gene expression of insulin and the insulin receptor and its protein levels to clarify the exact action of CORT on the neuronal insulin receptor function...
  3. ncbi Glucose metabolism and insulin receptor signal transduction in Alzheimer disease
    Siegfried Hoyer
    Department of Pathology, University of Heidelberg, Im Neuenheimer Feld 220 221, 69120 Heidelberg, Germany
    Eur J Pharmacol 490:115-25. 2004
    ..In late-onset sporadic Alzheimer disease changes in the brain are similar to those caused by non-insulin-dependent diabetes mellitus...
  4. ncbi Relationship between cerebral energy metabolism in parietotemporal cortex and hippocampus and mental activity during aging in rats
    S Hoyer
    Department of Pathology, University of Heidelberg, Heidelberg, Germany
    J Neural Transm 111:575-89. 2004
    ..In human beings, PP approximately poorly educated people found to be prone to sporadic Alzheimer disease...
  5. ncbi The aging brain. Changes in the neuronal insulin/insulin receptor signal transduction cascade trigger late-onset sporadic Alzheimer disease (SAD). A mini-review
    Siegfried Hoyer
    Department of Pathochemistry and General Neurochemistry, Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220 221, D 69120 Heidelberg, Federal Republic of Germany
    J Neural Transm 109:991-1002. 2002
    ..These processes as a whole may increase the vulnerability of the aging brain and may facilitate the generation of late-onset sporadic AD...
  6. ncbi Inhibition of the neuronal insulin receptor. An in vivo model for sporadic Alzheimer disease?
    S Hoyer
    Department of Pathochemistry and General Neurochemistry, University of Heidelberg, Im Neuenheimer Feld 220 221, D 69120 Heidelberg, Germany
    Ann N Y Acad Sci 920:256-8. 2000
    ..To prove this, this receptor was inhibited by a triplicate icv application of STZ. Insulin binding sites were upregulated as in SAD. With respect to glucose transport proteins, detailed investigations are necessary...
  7. doi Insulin-resistant brain state after intracerebroventricular streptozotocin injection exacerbates Alzheimer-like changes in Tg2576 AbetaPP-overexpressing mice
    Konstanze Plaschke
    Clinic of Anesthesiology, University of Heidelberg Medical School, Heidelberg, Germany
    J Alzheimers Dis 19:691-704. 2010
    ..In conclusion, IRBS may aggravate AD-like changes such as behavioral and increase the formation of pathomorphological AD hallmarks via GSK-3alpha/beta pathway in AbetaPP-overexpressing mice...
  8. doi Insulin-resistant brain state (IRBS) changes membrane composition of fatty acids in temporal and entorhinal brain cortices of rats: relevance to sporadic Alzheimer's disease?
    Konstanze Plaschke
    Department of Anesthesiology, Experimental Anesthesiology, Medical Faculty of the University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    J Neural Transm 117:1419-22. 2010
    ..The relevance of these changes is discussed in relation to sporadic Alzheimer's disease...
  9. ncbi Causes and consequences of disturbances of cerebral glucose metabolism in sporadic Alzheimer disease: therapeutic implications
    Siegfried Hoyer
    Department of Pathochemistry and General Neurochemistry, University of Heidelberg, Im Neuenheimer Feld 220 221, Heidelberg, Germany 69120
    Adv Exp Med Biol 541:135-52. 2004
    ..Therefore, the therapeutic goal in SAD should be the improvement of the neuronal energy state. Findings from both basic and clinical studies showed that Ginkgo biloba extract (EGb 761) may be appropiate to approach that goal...
  10. ncbi Alzheimer disease--no target for statin treatment. A mini review
    Siegfried Hoyer
    Department of Pathology, University of Heidelberg, Im Neuenheimer Feld 220 221, D 69120 Heidelberg, Germany
    Neurochem Res 32:695-706. 2007
    ..However, this experimentally induced condition may not be compatible to sporadic AD. The application of statins in sporadic AD did not yield results to assume that this therapeutic strategy may prevent or treat successfully sporadic AD...
  11. ncbi Reduced brain antioxidant capacity in rat models of betacytotoxic-induced experimental sporadic Alzheimer's disease and diabetes mellitus
    Ismet Tahirovic
    Department of Chemistry, Faculty of Science, University of Sarajevo, Zmaja od Bosne 35, 71 000, Sarajevo, Bosnia and Herzegovina
    Neurochem Res 32:1709-17. 2007
    ..Only those diabetic animals which demonstrated decreased withdrawal threshold values in comparison with the control non-diabetic animals (C) were considered to have developed the PDN...
  12. ncbi Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein
    Edna Grunblatt
    Clinical Neurochemistry and National Parkinson Foundation Centre of Excellence Laboratory, Clinic for Psychiatry and Psychotherapy, Bayrische Julius Maximilian University of Würzburg, Wurzburg, Germany
    J Neurochem 101:757-70. 2007
    ..Brain insulin system dysfunction is discussed as possible pathological core in the generation of hyperphosphorylated tau protein as a morphological marker of sporadic Alzheimer's disease...
  13. ncbi Gene expression alterations in brain areas of intracerebroventricular streptozotocin treated rat
    Edna Grunblatt
    Institute of Clinical Neurochemistry, National Parkinson Foundation Centre of Excellence Laboratories, Bayerische Julius Maximilians University of Würzburg, D 97080 Wurzburg, Germany
    J Alzheimers Dis 9:261-71. 2006
    ..Additionally, similarities to neuronal cell death in sporadic Alzheimer's disease may become apparent...
  14. ncbi Alzheimer-like changes in protein kinase B and glycogen synthase kinase-3 in rat frontal cortex and hippocampus after damage to the insulin signalling pathway
    Melita Salkovic-Petrisic
    Department of Pharmacology and Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Zagreb, Croatia
    J Neurochem 96:1005-15. 2006
    ..The IR signalling cascade alteration and its consequences in rats treated with STZ are similar to those found in humans with sporadic Alzheimer's disease, and our results suggest a role for GLUT2 in Alzheimer's pathophysiology...
  15. ncbi Cultivation in glucose-deprived medium stimulates mitochondrial biogenesis and oxidative metabolism in HepG2 hepatoma cells
    Katharina Weber
    Institut für Vegetative Physiologie, Universitat zu Koln, Germany
    Biol Chem 383:283-90. 2002
    ..These results show that mitochondrial biogenesis and oxidative metabolism are stimulated in HepG2 cells grown in the absence of fermentable glucose, probably in order to compensate for the diminished supply of glycolytic ATP...
  16. ncbi The role of the metabolic lesion in Alzheimer's disease
    John P Blass
    Weill Cornell Medical College at Burke Medical Research Institute, 785 Mamaroneck Ave, White Plains, NY 10605, USA
    J Alzheimers Dis 4:225-32. 2002
    ..However, those other abnormalities including amyloidosis can occur in people whose mentation is still clinically unimpaired. In contrast, once significant decrease in the rate of brain metabolism occurs, mentation becomes defective...
  17. ncbi Cholesterol and Alzheimer's disease
    Siegfried Hoyer
    Neurology 59:150; author reply 150-1. 2002