S Hoyer

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi request reprint The brain insulin signal transduction system and sporadic (type II) Alzheimer disease: an update
    S Hoyer
    Department of Pathochemistry and General Neurochemistry, University of Heidelberg, Federal Republic of Germany
    J Neural Transm 109:341-60. 2002
  2. ncbi request reprint Inhibition of the neuronal insulin receptor. An in vivo model for sporadic Alzheimer disease?
    S Hoyer
    Department of Pathochemistry and General Neurochemistry, University of Heidelberg, Im Neuenheimer Feld 220 221, D 69120 Heidelberg, Germany
    Ann N Y Acad Sci 920:256-8. 2000
  3. ncbi request reprint Relationship between cerebral energy metabolism in parietotemporal cortex and hippocampus and mental activity during aging in rats
    S Hoyer
    Department of Pathology, University of Heidelberg, Heidelberg, Germany
    J Neural Transm 111:575-89. 2004
  4. ncbi request reprint Brain glucose and energy metabolism abnormalities in sporadic Alzheimer disease. Causes and consequences: an update
    S Hoyer
    Department of Pathochemistry and General Neurochemistry, University of Heidelberg, Im Neuenheimer Feld 220 221, 69120, Heidelberg, Germany
    Exp Gerontol 35:1363-72. 2000
  5. ncbi request reprint Effect of Ginkgo biloba extract (EGb761) on glucose metabolism-related markers in streptozotocin-damaged rat brain
    T Löffler
    Paul Flechsig Institute for Brain Research, University of Leipzig, Leipzig, Federal Republic of Germany
    J Neural Transm 108:1457-74. 2001
  6. ncbi request reprint Differentiated effect of ageing on the enzymes of Krebs' cycle, electron transfer complexes and glutamate metabolism of non-synaptic and intra-synaptic mitochondria from cerebral cortex
    R F Villa
    Department of Physiological Pharmacological Cellular Molecular Sciences, Laboratory of Neurochemistry and Molecular Medicine, University of Pavia, Pavia, Italy
    J Neural Transm 113:1659-70. 2006
  7. ncbi request reprint [Pathomechanisms and hypothesis-guided therapeutic strategies for late-onset Alzheimer's disease]
    S Hoyer
    Abteilung für Pathochemie und Allgemeine Neurochemie, Universitat Heidelberg
    Fortschr Neurol Psychiatr 71:S16-26. 2003
  8. ncbi request reprint Memory function and brain glucose metabolism
    S Hoyer
    Dept of Pathochemistry and General Neurochemistry, Institute of Pathology of the University, Im Neuenheimer Feld 220 221, 69120 Heidelberg, Germany
    Pharmacopsychiatry 36:S62-7. 2003
  9. ncbi request reprint Alois Alzheimer revisited: differences in origin of the disease carrying his name
    K Maurer
    Clinic for Psychiatry, University of Frankfurt, Frankfurt Main, Germany
    J Neural Transm 113:1645-58. 2006
  10. ncbi request reprint From benefit to damage. Glutamate and advanced glycation end products in Alzheimer brain
    P Riederer
    Institute of Clinical Neurochemistry and National Parkinson Foundation Centre of Excellence Laboratory, Clinic for Psychiatry and Psychotherapy, Bayerische Julius Maximilians University of Würzburg, Wurzburg, Germany
    J Neural Transm 113:1671-7. 2006

Collaborators

Detail Information

Publications16

  1. ncbi request reprint The brain insulin signal transduction system and sporadic (type II) Alzheimer disease: an update
    S Hoyer
    Department of Pathochemistry and General Neurochemistry, University of Heidelberg, Federal Republic of Germany
    J Neural Transm 109:341-60. 2002
    ..Sporadic Alzheimer disease may, thus, be considered to be the brain type of diabetes mellitus II. Experimental evidence is provided and discussed...
  2. ncbi request reprint Inhibition of the neuronal insulin receptor. An in vivo model for sporadic Alzheimer disease?
    S Hoyer
    Department of Pathochemistry and General Neurochemistry, University of Heidelberg, Im Neuenheimer Feld 220 221, D 69120 Heidelberg, Germany
    Ann N Y Acad Sci 920:256-8. 2000
    ..To prove this, this receptor was inhibited by a triplicate icv application of STZ. Insulin binding sites were upregulated as in SAD. With respect to glucose transport proteins, detailed investigations are necessary...
  3. ncbi request reprint Relationship between cerebral energy metabolism in parietotemporal cortex and hippocampus and mental activity during aging in rats
    S Hoyer
    Department of Pathology, University of Heidelberg, Heidelberg, Germany
    J Neural Transm 111:575-89. 2004
    ..In human beings, PP approximately poorly educated people found to be prone to sporadic Alzheimer disease...
  4. ncbi request reprint Brain glucose and energy metabolism abnormalities in sporadic Alzheimer disease. Causes and consequences: an update
    S Hoyer
    Department of Pathochemistry and General Neurochemistry, University of Heidelberg, Im Neuenheimer Feld 220 221, 69120, Heidelberg, Germany
    Exp Gerontol 35:1363-72. 2000
    ....
  5. ncbi request reprint Effect of Ginkgo biloba extract (EGb761) on glucose metabolism-related markers in streptozotocin-damaged rat brain
    T Löffler
    Paul Flechsig Institute for Brain Research, University of Leipzig, Leipzig, Federal Republic of Germany
    J Neural Transm 108:1457-74. 2001
    ..The data suggest beneficial effects of EGb671 on impaired brain glucose metabolism, at least under the experimental conditions used in the study presented...
  6. ncbi request reprint Differentiated effect of ageing on the enzymes of Krebs' cycle, electron transfer complexes and glutamate metabolism of non-synaptic and intra-synaptic mitochondria from cerebral cortex
    R F Villa
    Department of Physiological Pharmacological Cellular Molecular Sciences, Laboratory of Neurochemistry and Molecular Medicine, University of Pavia, Pavia, Italy
    J Neural Transm 113:1659-70. 2006
    ..These results indicate a different age-related vulnerability of subpopulations of mitochondria in vivo located into synapses than non-synaptic ones...
  7. ncbi request reprint [Pathomechanisms and hypothesis-guided therapeutic strategies for late-onset Alzheimer's disease]
    S Hoyer
    Abteilung für Pathochemie und Allgemeine Neurochemie, Universitat Heidelberg
    Fortschr Neurol Psychiatr 71:S16-26. 2003
    ..Future development must take in account that with sporadic AD aging influences cannot or can hardly be influenced. Therapeutic goals should consist to improve the cellular energy status and the membrane functioning...
  8. ncbi request reprint Memory function and brain glucose metabolism
    S Hoyer
    Dept of Pathochemistry and General Neurochemistry, Institute of Pathology of the University, Im Neuenheimer Feld 220 221, 69120 Heidelberg, Germany
    Pharmacopsychiatry 36:S62-7. 2003
    ..Mimicking these metabolic and behavioral abnormalities in experimental animals, it was found that EGb 761 (definition see editorial) shows beneficial effects both on brain glucose and energy metabolism and on behavior...
  9. ncbi request reprint Alois Alzheimer revisited: differences in origin of the disease carrying his name
    K Maurer
    Clinic for Psychiatry, University of Frankfurt, Frankfurt Main, Germany
    J Neural Transm 113:1645-58. 2006
    ..Alois Alzheimer may have been so prescient to assume most of this 100 years ago...
  10. ncbi request reprint From benefit to damage. Glutamate and advanced glycation end products in Alzheimer brain
    P Riederer
    Institute of Clinical Neurochemistry and National Parkinson Foundation Centre of Excellence Laboratory, Clinic for Psychiatry and Psychotherapy, Bayerische Julius Maximilians University of Würzburg, Wurzburg, Germany
    J Neural Transm 113:1671-7. 2006
    ..First data from animal studies and investigations on human beings may indicate that the NMDA receptor antagonist memantine may have beneficial effects on the course of SAD and its clinical symptoms...
  11. ncbi request reprint Odour and taste sensitivity is associated with body weight and extent of misreporting of body weight
    U Simchen
    German Institute of Human Nutrition, Potsdam Rehbruecke, Germany
    Eur J Clin Nutr 60:698-705. 2006
    ..Sensory factors are important determinants of appetite and food choices but little is known about the relationship between body weight and sensory capabilities...
  12. ncbi request reprint Central administration of alloxan impairs glucose tolerance in rats
    M Salkovic-Petrisic
    Department of Pharmacology, School of Medicine and Croatian Institute for Brain Research, University of Zagreb, Croatia
    J Neural Transm 112:1391-5. 2005
    ..Centrally administered alloxan seems to have brain related effect on the regulation of peripheral glucose tolerance and insulin secretion...
  13. ncbi request reprint Gene expression profile in streptozotocin rat model for sporadic Alzheimer's disease
    E Grunblatt
    Department of Neurochemistry, Clinic for Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Neural Transm 111:367-86. 2004
    ..These pathways may reveal molecular events causing the neuronal death in SAD...
  14. ncbi request reprint ATPases of synaptic plasma membranes from hippocampus after ischemia and recovery during ageing
    R F Villa
    Department of Physiological Pharmacological Cellular Molecular Sciences, University of Pavia, Italy
    Neurochem Res 27:861-70. 2002
    ....
  15. ncbi request reprint [Etiologic and pathogenetic heterogeneity of Alzheimer disease]
    L Frolich
    Klinik für Psychiatrie und Psychotherapie I, Klinikum der Johann Wolfgang Goethe Universitat, Heinrich Hoffmannstrasse 10, 60528 Frankfurt Main
    Nervenarzt 73:422-7. 2002
    ..Therefore, the sporadic subtype of AD may be regarded as an age-associated metabolic disease of the brain...
  16. ncbi request reprint Antioxidant capacity in rat brain after intracerebroventricular treatment with streptozotocin and alloxan--a preliminary study
    A Sapcanin
    Department of Chemistry, Faculty of Science, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
    Neurotox Res 13:97-104. 2008
    ....