Affiliation: University of Heidelberg
- The brain insulin signal transduction system and sporadic (type II) Alzheimer disease: an updateS Hoyer
Department of Pathochemistry and General Neurochemistry, University of Heidelberg, Federal Republic of Germany
J Neural Transm 109:341-60. 2002..Sporadic Alzheimer disease may, thus, be considered to be the brain type of diabetes mellitus II. Experimental evidence is provided and discussed...
- Inhibition of the neuronal insulin receptor. An in vivo model for sporadic Alzheimer disease?S Hoyer
Department of Pathochemistry and General Neurochemistry, University of Heidelberg, Im Neuenheimer Feld 220 221, D 69120 Heidelberg, Germany
Ann N Y Acad Sci 920:256-8. 2000..To prove this, this receptor was inhibited by a triplicate icv application of STZ. Insulin binding sites were upregulated as in SAD. With respect to glucose transport proteins, detailed investigations are necessary...
- Relationship between cerebral energy metabolism in parietotemporal cortex and hippocampus and mental activity during aging in ratsS Hoyer
Department of Pathology, University of Heidelberg, Heidelberg, Germany
J Neural Transm 111:575-89. 2004..In human beings, PP approximately poorly educated people found to be prone to sporadic Alzheimer disease...
- Brain glucose and energy metabolism abnormalities in sporadic Alzheimer disease. Causes and consequences: an updateS Hoyer
Department of Pathochemistry and General Neurochemistry, University of Heidelberg, Im Neuenheimer Feld 220 221, 69120, Heidelberg, Germany
Exp Gerontol 35:1363-72. 2000....
- Effect of Ginkgo biloba extract (EGb761) on glucose metabolism-related markers in streptozotocin-damaged rat brainT Löffler
Paul Flechsig Institute for Brain Research, University of Leipzig, Leipzig, Federal Republic of Germany
J Neural Transm 108:1457-74. 2001..The data suggest beneficial effects of EGb671 on impaired brain glucose metabolism, at least under the experimental conditions used in the study presented...
- Differentiated effect of ageing on the enzymes of Krebs' cycle, electron transfer complexes and glutamate metabolism of non-synaptic and intra-synaptic mitochondria from cerebral cortexR F Villa
Department of Physiological Pharmacological Cellular Molecular Sciences, Laboratory of Neurochemistry and Molecular Medicine, University of Pavia, Pavia, Italy
J Neural Transm 113:1659-70. 2006..These results indicate a different age-related vulnerability of subpopulations of mitochondria in vivo located into synapses than non-synaptic ones...
- [Pathomechanisms and hypothesis-guided therapeutic strategies for late-onset Alzheimer's disease]S Hoyer
Abteilung für Pathochemie und Allgemeine Neurochemie, Universitat Heidelberg
Fortschr Neurol Psychiatr 71:S16-26. 2003..Future development must take in account that with sporadic AD aging influences cannot or can hardly be influenced. Therapeutic goals should consist to improve the cellular energy status and the membrane functioning...
- Memory function and brain glucose metabolismS Hoyer
Dept of Pathochemistry and General Neurochemistry, Institute of Pathology of the University, Im Neuenheimer Feld 220 221, 69120 Heidelberg, Germany
Pharmacopsychiatry 36:S62-7. 2003..Mimicking these metabolic and behavioral abnormalities in experimental animals, it was found that EGb 761 (definition see editorial) shows beneficial effects both on brain glucose and energy metabolism and on behavior...
- Alois Alzheimer revisited: differences in origin of the disease carrying his nameK Maurer
Clinic for Psychiatry, University of Frankfurt, Frankfurt Main, Germany
J Neural Transm 113:1645-58. 2006..Alois Alzheimer may have been so prescient to assume most of this 100 years ago...
- From benefit to damage. Glutamate and advanced glycation end products in Alzheimer brainP Riederer
Institute of Clinical Neurochemistry and National Parkinson Foundation Centre of Excellence Laboratory, Clinic for Psychiatry and Psychotherapy, Bayerische Julius Maximilians University of Würzburg, Wurzburg, Germany
J Neural Transm 113:1671-7. 2006..First data from animal studies and investigations on human beings may indicate that the NMDA receptor antagonist memantine may have beneficial effects on the course of SAD and its clinical symptoms...
- Odour and taste sensitivity is associated with body weight and extent of misreporting of body weightU Simchen
German Institute of Human Nutrition, Potsdam Rehbruecke, Germany
Eur J Clin Nutr 60:698-705. 2006..Sensory factors are important determinants of appetite and food choices but little is known about the relationship between body weight and sensory capabilities...
- Central administration of alloxan impairs glucose tolerance in ratsM Salkovic-Petrisic
Department of Pharmacology, School of Medicine and Croatian Institute for Brain Research, University of Zagreb, Croatia
J Neural Transm 112:1391-5. 2005..Centrally administered alloxan seems to have brain related effect on the regulation of peripheral glucose tolerance and insulin secretion...
- Gene expression profile in streptozotocin rat model for sporadic Alzheimer's diseaseE Grunblatt
Department of Neurochemistry, Clinic for Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
J Neural Transm 111:367-86. 2004..These pathways may reveal molecular events causing the neuronal death in SAD...
- ATPases of synaptic plasma membranes from hippocampus after ischemia and recovery during ageingR F Villa
Department of Physiological Pharmacological Cellular Molecular Sciences, University of Pavia, Italy
Neurochem Res 27:861-70. 2002....
- [Etiologic and pathogenetic heterogeneity of Alzheimer disease]L Frolich
Klinik für Psychiatrie und Psychotherapie I, Klinikum der Johann Wolfgang Goethe Universitat, Heinrich Hoffmannstrasse 10, 60528 Frankfurt Main
Nervenarzt 73:422-7. 2002..Therefore, the sporadic subtype of AD may be regarded as an age-associated metabolic disease of the brain...
- Antioxidant capacity in rat brain after intracerebroventricular treatment with streptozotocin and alloxan--a preliminary studyA Sapcanin
Department of Chemistry, Faculty of Science, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Neurotox Res 13:97-104. 2008....