M Hornyak

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. doi Efficacy and safety of dopamine agonists in restless legs syndrome
    Magdolna Hornyak
    Interdisciplinary Pain Centre, University Medical Centre, Breisacher Strasse 64, 79106 Freiburg, Germany
    Sleep Med 13:228-36. 2012
  2. pmc Psychological distress of patients suffering from restless legs syndrome: a cross-sectional study
    Hanna Scholz
    Interdisciplinary Pain Centre, University Medical Centre, Freiburg 79106, Germany
    Health Qual Life Outcomes 9:73. 2011
  3. doi Depressive disorders in restless legs syndrome: epidemiology, pathophysiology and management
    Magdolna Hornyak
    Interdisciplinary Pain Center and Department of Psychiatry and Psychotherapy, University Medical Center, Breisacher Strasse 64, Freiburg, Germany
    CNS Drugs 24:89-98. 2010
  4. doi [Depression in restless legs syndrome. Pathogenesis, assessment, and implications for treatment]
    M Hornyak
    Interdisziplinäres Schmerzzentrum und Abteilung für Psychiatrie und Psychotherapie, Freiburg, Universitatsklinikum, 79106, Freiburg, Deutschland
    Nervenarzt 80:1160-6, 1164-6, 1168. 2009
  5. ncbi Voxel-based morphometry in unmedicated patients with restless legs syndrome
    Magdolna Hornyak
    Center for Sleep Research and Sleep Medicine, Department of Psychiatry and Psychotherapy, University Hospital, Freiburg, Germany
    Sleep Med 9:22-6. 2007
  6. doi Evaluation of painful sensory symptoms in restless legs syndrome: experience from two clinical trials
    Magdolna Hornyak
    Interdisciplinary Pain Center, University Medical Center, Breisacher Strasse 64, 79106 Freiburg, Germany
    Sleep Med 12:186-9. 2011
  7. doi [Restless legs syndrome and nocturnal leg pain : Differential diagnosis and treatment]
    M Hornyak
    Interdisziplinäres Schmerzzentrum, Universitatsklinikum Freiburg, Breisacher Str 64, 79106, Freiburg, Deutschland
    Schmerz 25:544-51. 2011
  8. doi Low-dose hydrocortisone in the evening modulates symptom severity in restless legs syndrome
    M Hornyak
    Center for Sleep Research and Sleep Medicine, Department of Psychiatry and Psychotherapy, University Medical Center, Freiburg, Germany
    Neurology 70:1620-2. 2008
  9. doi Cognitive behavioural group therapy to improve patients' strategies for coping with restless legs syndrome: a proof-of-concept trial
    M Hornyak
    Interdisciplinary Pain Centre and Department of Psychiatry and Psychotherapy, University Medical Centre, Breisacher Strasse 64, D 79106 Freiburg, Germany
    J Neurol Neurosurg Psychiatry 79:823-5. 2008
  10. pmc Polysomnography findings in patients with restless legs syndrome and in healthy controls: a comparative observational study
    Magdolna Hornyak
    Center for Sleep Research and Sleep Medicine, Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Germany
    Sleep 30:861-5. 2007

Detail Information

Publications42

  1. doi Efficacy and safety of dopamine agonists in restless legs syndrome
    Magdolna Hornyak
    Interdisciplinary Pain Centre, University Medical Centre, Breisacher Strasse 64, 79106 Freiburg, Germany
    Sleep Med 13:228-36. 2012
    ..This article is an overview of a comprehensive Cochrane meta-analysis on the efficacy and safety of dopamine agonists (DAs), the first-line treatment of RLS...
  2. pmc Psychological distress of patients suffering from restless legs syndrome: a cross-sectional study
    Hanna Scholz
    Interdisciplinary Pain Centre, University Medical Centre, Freiburg 79106, Germany
    Health Qual Life Outcomes 9:73. 2011
    ..Little is known about the psychological characteristics of RLS patients although psychological factors may contribute to unfavourable treatment outcome...
  3. doi Depressive disorders in restless legs syndrome: epidemiology, pathophysiology and management
    Magdolna Hornyak
    Interdisciplinary Pain Center and Department of Psychiatry and Psychotherapy, University Medical Center, Breisacher Strasse 64, Freiburg, Germany
    CNS Drugs 24:89-98. 2010
    ..Data from recent trials with dopamine receptor agonists indicate that mild to moderate depressive symptoms are often relieved with improvement of RLS symptoms...
  4. doi [Depression in restless legs syndrome. Pathogenesis, assessment, and implications for treatment]
    M Hornyak
    Interdisziplinäres Schmerzzentrum und Abteilung für Psychiatrie und Psychotherapie, Freiburg, Universitatsklinikum, 79106, Freiburg, Deutschland
    Nervenarzt 80:1160-6, 1164-6, 1168. 2009
    ..In the present work, the clinical relevance of depression in RLS and antidepressive treatment in RLS symptoms is discussed and a therapeutic algorithm (evidence level C) for the treatment of depression in RLS is provided...
  5. ncbi Voxel-based morphometry in unmedicated patients with restless legs syndrome
    Magdolna Hornyak
    Center for Sleep Research and Sleep Medicine, Department of Psychiatry and Psychotherapy, University Hospital, Freiburg, Germany
    Sleep Med 9:22-6. 2007
    ..To address this issue, we performed VBM in unmedicated RLS patients...
  6. doi Evaluation of painful sensory symptoms in restless legs syndrome: experience from two clinical trials
    Magdolna Hornyak
    Interdisciplinary Pain Center, University Medical Center, Breisacher Strasse 64, 79106 Freiburg, Germany
    Sleep Med 12:186-9. 2011
    ..Although "uncomfortable and unpleasant" limb sensations are a core symptom of restless legs syndrome (RLS), change in sensory symptomatology is usually not evaluated as a treatment outcome...
  7. doi [Restless legs syndrome and nocturnal leg pain : Differential diagnosis and treatment]
    M Hornyak
    Interdisziplinäres Schmerzzentrum, Universitatsklinikum Freiburg, Breisacher Str 64, 79106, Freiburg, Deutschland
    Schmerz 25:544-51. 2011
    ..In addition, the differential diagnoses for exclusion of other specific causes of nocturnal pain in the legs are discussed...
  8. doi Low-dose hydrocortisone in the evening modulates symptom severity in restless legs syndrome
    M Hornyak
    Center for Sleep Research and Sleep Medicine, Department of Psychiatry and Psychotherapy, University Medical Center, Freiburg, Germany
    Neurology 70:1620-2. 2008
    ..We investigated the effect of late-evening application of exogenous cortisol (hydrocortisone) on sensory leg discomfort (SLD), one of the main complaints of patients with RLS...
  9. doi Cognitive behavioural group therapy to improve patients' strategies for coping with restless legs syndrome: a proof-of-concept trial
    M Hornyak
    Interdisciplinary Pain Centre and Department of Psychiatry and Psychotherapy, University Medical Centre, Breisacher Strasse 64, D 79106 Freiburg, Germany
    J Neurol Neurosurg Psychiatry 79:823-5. 2008
    ..To date, no psychologically based approach is available to improve the coping strategies and quality of life of RLS sufferers...
  10. pmc Polysomnography findings in patients with restless legs syndrome and in healthy controls: a comparative observational study
    Magdolna Hornyak
    Center for Sleep Research and Sleep Medicine, Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Germany
    Sleep 30:861-5. 2007
    ..Sleep disturbances and their sequelae are the most common complaints of patients with restless legs syndrome (RLS). We compared polysomnography (PSG) findings in a large cohort of patients with idiopathic RLS and of healthy subjects...
  11. ncbi A double-blind, randomized and placebo-controlled study on the polysomnographic withdrawal effects of zopiclone, zolpidem and triazolam in healthy subjects
    U Voderholzer
    Department of Psychiatry and Psychotherapy, Klinikum of the Albert Ludwigs University Hauptstrasse 5 79104 Freiburg, Germany
    Eur Arch Psychiatry Clin Neurosci 251:117-23. 2001
    ..Assuming that rebound insomnia is part of a withdrawal reaction, this study indicates that the risks of tolerance and dependency are low when administering zopiclone or zolpidem at the recommended doses...
  12. ncbi Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome: an open pilot study
    M Hornyak
    Department of Psychiatry and Psychotherapy, Albert-Ludwigs-University, Freiburg, Germany
    Sleep 21:501-5. 1998
    ..Further investigations regarding the role of magnesium in the pathophysiology of RLS and placebo-controlled studies need to be performed...
  13. ncbi Restless legs syndrome in older adults
    Kai Spiegelhalder
    Sleep Disorders Center, Department of Psychiatry and Psychotherapy, University Hospital Freiburg, Hauptstrasse 5, D 79104 Freiburg, Germany
    Clin Geriatr Med 24:167-80, ix. 2008
    ..Secondary forms of RLS and possible interaction with other medications require particular consideration in the elderly...
  14. doi [Nicotine. Influence on sleep and its relevance for psychiatry and psychotherapy]
    A Jahne
    Abteilung für Psychiatrie und Psychotherapie, Universitatsklinikum Freiburg, Freiburg, Deutschland
    Nervenarzt 81:844-59. 2010
    ..Nicotine, by its impact on several neurotransmitter systems, influences sleep. Sleep disturbance is a common symptom in different psychiatric disorders and there is a high prevalence of smoking in psychiatric patients...
  15. doi Are adolescents chronically sleep-deprived? An investigation of sleep habits of adolescents in the Southwest of Germany
    B Loessl
    Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Hauptstrasse 5, 79104 Freiburg, Germany
    Child Care Health Dev 34:549-56. 2008
    ..Adolescent sleep receives increasing attention. Several studies have shown that adolescents generally do not sleep enough. This survey assessed adolescents' sleep patterns, and results were compared with sleep logs...
  16. ncbi Impact of sleep-related complaints on depressive symptoms in patients with restless legs syndrome
    Magdolna Hornyak
    Department of Psychiatry and Psychotherapy, University Hospital, Freiburg, Germany
    J Clin Psychiatry 66:1139-45. 2005
    ..RLS has been reported to be associated with depression and anxiety. The aim of the present study was to investigate the relationship between RLS symptom severity, sleep disturbances, and depressive symptoms...
  17. pmc Chronic insomnia and MRI-measured hippocampal volumes: a pilot study
    Dieter Riemann
    Department of Psychiatry and Psychotherapy, Freiburg University Medical Center, Hauptstr 5, D 79104 Germany
    Sleep 30:955-8. 2007
    ..Morphometric analysis of magnetic resonance imaging brain scans was used to investigate possible neuroanatomic differences between patients with primary insomnia compared to good sleepers...
  18. doi Does REM sleep contribute to subjective wake time in primary insomnia? A comparison of polysomnographic and subjective sleep in 100 patients
    Bernd Feige
    Department of Psychiatry and Psychotherapy, University Medical Center, Freiburg, Germany
    J Sleep Res 17:180-90. 2008
    ..This REM sleep contribution was larger for PI than for GSC subjects. The findings suggest that REM sleep-related processes might contribute to subjectively disturbed sleep and the perception of waking time in patients with PI...
  19. ncbi Spectral analysis of sleep EEG in patients with restless legs syndrome
    Magdolna Hornyak
    Department of Psychiatry and Psychotherapy, University Hospital, Hauptstrasse 5, D 79104 Freiburg, Germany
    Clin Neurophysiol 116:1265-72. 2005
    ..Furthermore, we studied the relationship of sleep EEG spectral power to the occurrence of periodic leg movements in sleep (PLMS) and arousal events...
  20. ncbi Sleep and sleep disorders in adults with attention deficit/hyperactivity disorder
    Alexandra Philipsen
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Haupt strasse 5, 79104 Freiburg, Germany
    Sleep Med Rev 10:399-405. 2006
    ..To date, larger studies with adequate sample sizes that compare sleep in adult patients with ADHD, healthy control groups and patients with other primary sleep disorders are still lacking...
  21. ncbi Periodic leg movements in sleep and periodic limb movement disorder: prevalence, clinical significance and treatment
    Magdolna Hornyak
    Department of Psychiatry and Psychotherapy, University Hospital Freiburg, Hauptstrasse 5, D 79104 Freiburg, Germany
    Sleep Med Rev 10:169-77. 2006
    ..To date, only a few studies have evaluated the efficacy of therapeutic substances in reducing PLMS in PLMD patients. Their results need to be confirmed in controlled randomized trials...
  22. doi Cerebral correlates of heart rate variations during a spontaneous panic attack in the fMRI scanner
    Kai Spiegelhalder
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical Center, Hauptstrasse 5, 79104 Freiburg, Germany
    Neurocase 15:527-34. 2009
    ..Additionally, regions-of-interest (ROI) analyses indicated significant positive associations in the left amygdala, and trends towards significance in the right amygdala and left insula...
  23. ncbi [Restless legs syndrome in childhood]
    M Hornyak
    Abteilung für Psychiatrie und Psychotherapie der Universität Freiburg, Freiburg, Deutschland
    Nervenarzt 75:742-8. 2004
    ....
  24. ncbi Sleep in adults with attention-deficit/hyperactivity disorder: a controlled polysomnographic study including spectral analysis of the sleep EEG
    Alexandra Philipsen
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Germany
    Sleep 28:877-84. 2005
    ..We investigated objective and subjective sleep quality in adultADHD, including an electroencephalogram spectral power analysis...
  25. ncbi Relationship of periodic leg movements and severity of restless legs syndrome: a study in unmedicated and medicated patients
    Magdolna Hornyak
    Department of Psychiatry and Psychotherapy, University Medical Center, Freiburg, Germany
    Clin Neurophysiol 118:1532-7. 2007
    ....
  26. ncbi The tryptophan depletion test: impact on sleep in primary insomnia - a pilot study
    Dieter Riemann
    Department of Psychiatry and Psychotherapy, University of Freiburg, Hauptstrasse 5, Germany
    Psychiatry Res 109:129-35. 2002
    ..The results suggest a negative impact of tryptophan depletion on sleep continuity and a stimulating effect on phasic measures of REM sleep in patients with primary insomnia...
  27. ncbi Variability of periodic leg movements in various sleep disorders: implications for clinical and pathophysiologic studies
    Magdolna Hornyak
    Sleep Disorders Unit, Department of Psychiatry and Psychotherapy, University Hospital, Freiburg, Germany
    Sleep 28:331-5. 2005
    ..In the present study, we investigated the intrasubject variance of PLMS from one night to the other because a fluctuation in the number of PLMS may influence the outcome of pharmacologic and pathophysiologic studies...
  28. ncbi Do periodic leg movements influence patients' perception of sleep quality?
    Magdolna Hornyak
    Department of Psychiatry and Psychotherapy, University Hospital of Freiburg, Hauptstrasse 5, D 79104 Freiburg, Germany
    Sleep Med 5:597-600. 2004
    ..We investigated the relationship of the occurrence of PLMS to patients' perception of sleep quality during a night of polysomnography in various sleep disorders...
  29. ncbi Sleep electroencephalographic spectral power after withdrawal from alcohol in alcohol-dependent patients
    Bernd Feige
    Department of Psychiatry and Psychotherapy, University of Freiburg, Hauptstrasse 5, Freiburg 79104, Germany
    Alcohol Clin Exp Res 31:19-27. 2007
    ..Our hypothesis was that the subgroup of patients who relapsed within the 3 months to follow-up would exhibit-increased dysfunctional arousal manifested by higher-frequency (beta) EEG power during sleep...
  30. ncbi Restless legs syndrome and periodic limb movement disorder in the elderly
    Magdolna Hornyak
    Department of Psychiatry and Psychotherapy, University of Freiburg, Hauptstrasse 5, D 79104 Freiburg, Germany
    J Psychosom Res 56:543-8. 2004
    ..However, interaction with other medications and the possibility of severe sedation due to slower metabolism in the elderly should be considered...
  31. ncbi Cerebral correlates of muscle tone fluctuations in restless legs syndrome: a pilot study with combined functional magnetic resonance imaging and anterior tibial muscle electromyography
    Kai Spiegelhalder
    Department of Psychiatry and Psychotherapy, University Hospital, Hauptstrasse 5, 79104 Freiburg, Germany
    Sleep Med 9:177-83. 2008
    ..To investigate the pathomechanism of the disorder further we recorded a surface electromyogram (EMG) of the anterior tibial muscle during functional magnetic resonance imaging (fMRI) in patients with idiopathic RLS...
  32. ncbi Transient total sleep loss in cerebral Whipple's disease: a longitudinal study
    Ulrich Voderholzer
    Department of Psychiatry and Psychotherapy, University of Freiburg, Freiburg, Germany
    J Sleep Res 11:321-9. 2002
    ..The extent of sleep disruption in this case of organic insomnia was similar to cases of familial fatal insomnia, but was at least partially reversible with treatment...
  33. ncbi Effects of alcohol on polysomnographically recorded sleep in healthy subjects
    Bernd Feige
    Department of Psychiatry and Psychotherapy, University Hospital of Freiburg, Freiburg, Germany
    Alcohol Clin Exp Res 30:1527-37. 2006
    ..The study evaluated a short-term acute drinking period for 3 and 2 days of withdrawal from alcohol not only for polysomnographic variables but also for subjective estimates of sleep quality...
  34. ncbi Magnesium treatment of primary alcohol-dependent patients during subacute withdrawal: an open pilot study with polysomnography
    Magdolna Hornyak
    Department of Psychiatry and Psychotherapy, University Hospital of Freiburg, Hauptstrasse 5, D 79104 Freiburg, Germany
    Alcohol Clin Exp Res 28:1702-9. 2004
    ..We conducted an open pilot study to evaluate the effects of magnesium treatment on the sleep of primary alcohol-dependent patients during subacute withdrawal...
  35. doi Sleep and memory in healthy children and adolescents - a critical review
    Marta Kopasz
    Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Hauptstrasse 5, 79104 Freiburg, Germany
    Sleep Med Rev 14:167-77. 2010
    ..This line of research can provide valuable input relevant to teaching, learning and public health policy...
  36. doi Effect of illicit recreational drugs upon sleep: cocaine, ecstasy and marijuana
    Thomas Schierenbeck
    Department of Psychiatry and Psychotherapy, Freiburg University Medical Center, Hauptstrasse 5, D 79104 Freiburg, Germany
    Sleep Med Rev 12:381-9. 2008
    ..Longer sleep onset latency, reduced slow wave sleep and a REM rebound can be observed. Prospective studies are needed in order to verify whether sleep disturbances during cocaine and cannabis withdrawal predict treatment outcome...
  37. doi No persisting effect of partial sleep curtailment on cognitive performance and declarative memory recall in adolescents
    Marta Kopasz
    Department of Psychiatry and Psychotherapy, University Medical Center, Freiburg, Germany
    J Sleep Res 19:71-9. 2010
    ..This may be explained by the high ability of adolescents to compensate for acute sleep loss. The correlation between non-REM sleep and declarative memory performance supports earlier findings...
  38. ncbi Validation of the Augmentation Severity Rating Scale (ASRS): a multicentric, prospective study with levodopa on restless legs syndrome
    Diego Garcia-Borreguero
    Fundacion Jimenez Diaz, Madrid, Spain
    Sleep Med 8:455-63. 2007
    ..The changes in each dimension are summed to give an ASRS total score...
  39. ncbi The official World Association of Sleep Medicine (WASM) standards for recording and scoring periodic leg movements in sleep (PLMS) and wakefulness (PLMW) developed in collaboration with a task force from the International Restless Legs Syndrome Study Grou
    Marco Zucconi
    Sleep Disorders Center, San Raffaele Hospital, Milano, Italy
    Sleep Med 7:175-83. 2006
  40. ncbi Clinical significance of RLS
    Wayne A Hening
    UMDNJ RW Johnson Medical School, New Brunswick, New Jersey, USA
    Mov Disord 22:S395-400. 2007
    ..In dialysis patients, RLS has been found to be a risk factor for mortality. Therefore, those with RLS who have clinically significant symptoms suffer increased morbidity and are at risk for impaired long-term medical outcomes...
  41. ncbi Clinical trials in restless legs syndrome--recommendations of the European RLS Study Group (EURLSSG)
    Claudia Trenkwalder
    Paracelsus Elena Hospital, Center of Parkinsonism and Movement Disorders, Klinikstr 16, 34128 Kassel, Germany
    Mov Disord 22:S495-504. 2007
    ..The aim of these recommendations is to support research groups or pharmaceutical companies in the design of optimized study protocols...
  42. ncbi Treatment of depression in patients with restless legs syndrome: what is evidence-based?
    Magdolna Hornyak
    Sleep Med 7:301-2; author reply 303-4. 2006