Research Topics
Genomes and Genes
| Veit HornungSummaryAffiliation: University of Bonn Country: Germany Publications
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Detail Information
Publications
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASCVeit Hornung
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Nature 458:514-8. 2009..Collectively, these observations identify AIM2 as a new receptor for cytoplasmic DNA, which forms an inflammasome with the ligand and ASC to activate caspase-1...
Intracellular DNA recognitionVeit Hornung
Institute for Clinical Chemistry and Pharmacology, University Hospital, University of Bonn, Bonn, Germany
Nat Rev Immunol 10:123-30. 2010..DNA can be detected in different cellular compartments and can induce a range of cellular responses, such as an antiviral response and pyroptotic cell death together with the maturation and release of active interleukin-1beta...- Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasomeSarah Kim
Institute for Clinical Chemistry and Pharmacology, Unit for Clinical Biochemistry, University Hospital, University of Bonn, Bonn, Germany
Eur J Immunol 40:1545-51. 2010..monocytogenes. Altogether, these data establish a role for DNA sensing through the AIM2 inflammasome in the detection of intracellularly replicating bacteria... - The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA virusesVijay A K Rathinam
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
Nat Immunol 11:395-402. 2010..Collectively, our observations demonstrate the importance of AIM2 in the sensing of both bacterial and viral pathogens and in triggering innate immunity... - NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystalsPeter Duewell
Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Nature 464:1357-61. 2010..These findings provide new insights into the pathogenesis of atherosclerosis and indicate new potential molecular targets for the therapy of this disease... - The NLRP3/ASC/Caspase-1 axis regulates IL-1β processing in neutrophilsArun K Mankan
Institute for Clinical Chemistry and Clinical Pharmacology, Unit for Clinical Biochemistry, University Hospital, University of Bonn, Bonn, Germany
Eur J Immunol 42:710-5. 2012..Our findings establish the NLRP3 inflammasome as a key step in the secretion of matured IL-1β by neutrophils... - Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expressionFranz G Bauernfeind
Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
J Immunol 183:787-91. 2009..Signals provided by NF-kappaB activators are necessary but not sufficient for NLRP3 activation, and a second stimulus such as ATP or crystal-induced damage is required for NLRP3 activation... - Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasomeFranz Bauernfeind
Unit for Clinical Biochemistry, Institute for Clinical Chemistry and Pharmacology, University Hospital, University of Bonn, 53127 Bonn, Germany
J Immunol 187:613-7. 2011..Although these data do not exclude a general role for ROS production in the process of NLRP3-triggered inflammation, they would put ROS upstream of NLRP3 induction, but not activation... - RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediateAndrea Ablasser
Institute for Clinical Chemistry and Pharmacology, University of Bonn, Bonn, Germany
Nat Immunol 10:1065-72. 2009..This pathway was important in the sensing of Epstein-Barr virus-encoded small RNAs, which were transcribed by RNA polymerase III and then triggered RIG-I activation. Thus, RNA polymerase III and RIG-I are pivotal in sensing viral DNA... - Critical role of nucleotide-binding oligomerization domain-like receptor 3 in vascular repairSebastian Schlaweck
Department of Medicine Cardiology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
Biochem Biophys Res Commun 411:627-31. 2011..In all, NLRP3 plays a non-redundant role in vascular damage mediated neointima formation. Our data establish NLRP3 as a key player in the response to vascular damage, which could open new avenues to therapeutic intervention... - Inflammasomes: current understanding and open questionsFranz Bauernfeind
Unit for Clinical Biochemistry, Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
Cell Mol Life Sci 68:765-83. 2011..In particular, we focus on the controversial molecular mechanisms that regulate NLRP3 signaling and highlight recent advancements in DNA sensing by the inflammasome receptor AIM2... - Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilizationVeit Hornung
Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Nat Immunol 9:847-56. 2008..Our results indicate that the NALP3 inflammasome senses lysosomal damage as an endogenous 'danger' signal... 
An unexpected role for RNA in the recognition of DNA by the innate immune systemFranz Bauernfeind
Institute for Clinical Chemistry and Pharmacology, Unit for Clinical Biochemistry, University Hospital, University of Bonn, Bonn, Germany
RNA Biol 7:151-7. 2010..In this review article, we will discuss the mechanisms and implications of this novel pathway...- NLRP3 inflammasome activity is negatively controlled by miR-223Franz Bauernfeind
Unit for Clinical Biochemistry, Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, 53127 Bonn, Germany
J Immunol 189:4175-81. 2012..Therefore, given the tight transcriptional control of NLRP3 message itself, miR-223 functions as an important rheostat controlling NLRP3 inflammasome activity... - Induction of type I IFNs by intracellular DNA-sensing pathwaysTaner Cavlar
Institute for Clinical Chemistry and Clinical Pharmacology, Unit for Clinical Biochemistry, University Hospital, University of Bonn, Bonn, Germany
Immunol Cell Biol 90:474-82. 2012..In this review, we outline the recent advancements in the elucidation of intracellular DNA-sensing pathways and discuss the future directions of this emerging field... - 5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanomaHendrik Poeck
Institute of Clinical Chemistry and Pharmacology, University Hospital, University of Bonn, Bonn, Germany
Nat Med 14:1256-63. 2008.... - The NALP3 inflammasome is involved in the innate immune response to amyloid-betaAnnett Halle
Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Nat Immunol 9:857-65. 2008..Our findings suggest that activation of the NALP3 inflammasome is important for inflammation and tissue damage in Alzheimer's disease... - Critical functions of priming and lysosomal damage for NLRP3 activationVeit Hornung
Institute for Clinical Chemistry and Pharmacology, University Hospital, University of Bonn, Bonn, Germany
Eur J Immunol 40:620-3. 2010..Here, we discuss the critical roles of priming and lysosomal damage in NLRP3 inflammasome activation... - Selection of molecular structure and delivery of RNA oligonucleotides to activate TLR7 versus TLR8 and to induce high amounts of IL-12p70 in primary human monocytesAndrea Ablasser
Institute of Clinical Chemistry and Pharmacology, University Hospital, University of Bonn, Bonn, Germany
J Immunol 182:6824-33. 2009.... - Retroviral Danger from Within: TLR7 Is in ControlArun K Mankan
Institute for Clinical Chemistry and Clinical Pharmacology, Unit for Clinical Biochemistry, University Hospital, University of Bonn, 53127 Bonn, Germany
Immunity 37:763-6. 2012.... - siRNA and isRNA: two edges of one swordMartin Schlee
Division of Clinical Pharmacology, Department of Medicine, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany
Mol Ther 14:463-70. 2006....