Lars Cristian Horn

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. ncbi request reprint Histopathology of endometrial hyperplasia and endometrial carcinoma: an update
    Lars Christian Horn
    Division of Gynecologic Pathology, Institute of Pathology, Leipzig University, D 04103 Leipzig, Germany
    Ann Diagn Pathol 11:297-311. 2007
  2. ncbi request reprint [Morphology of secondary ovarian tumors and metastases]
    L C Horn
    Abteilung Mamma, Gynäko and Perinatalpathologie, Institut fur Pathologie, Department für Diagnostik, Universitatsklinikum Leipzig AoR, Liebigstr 24, 04103, Leipzig, Deutschland
    Pathologe 35:336-47. 2014
  3. ncbi request reprint A cut-off value of 2 cm in tumor size is of prognostic value in surgically treated FIGO stage IB cervical cancer
    Lars Christian Horn
    Institute of Pathology, Division of Breast, Gynecologic and Perinatal Pathology, University of Leipzig, Germany Electronic address
    Gynecol Oncol 134:42-6. 2014
  4. doi request reprint CD34(low) and SMA(high) represent stromal signature in uterine cervical cancer and are markers for peritumoral stromal remodeling
    Lars Christian Horn
    Institute of Pathology, Division of Breast, Gynecologic and Perinatal Pathology, University of Leipzig, Leipzig, Germany Electronic address
    Ann Diagn Pathol 17:531-5. 2013
  5. doi request reprint Serous tubal in situ carcinoma (STIC) in primary peritoneal serous carcinomas
    Lars Christian Horn
    Division of Breast, Gynecologic and Perinatal Pathology, Institute of Trier, University of Leipzig, Leipzig, Germany
    Int J Gynecol Pathol 32:339-44. 2013
  6. ncbi request reprint Peritumoral stromal remodeling, pattern of invasion and expression of c-met/HGF in advanced squamous cell carcinoma of the cervix uteri, FIGO stages III and IV
    L C Horn
    Institute of Pathology, Division of Breast, Gynecologic and Perinatal Pathology, University of Leipzig, Leipzig, Germany
    Eur J Obstet Gynecol Reprod Biol 163:76-80. 2012
  7. doi request reprint c-kit/CD 117 positive cells in the myometrium of pregnant women and those with uterine endometriosis
    L C Horn
    Institute of Pathology, University of Leipzig, Germany
    Arch Gynecol Obstet 286:105-7. 2012
  8. ncbi request reprint COX-2 and Her-2/neu are overexpressed in Paget's disease of the vulva and the breast: results of a preliminary study
    Lars Christian Horn
    Institute of Pathology, Division of Gynecologic and Perinatal Pathology, University of Leipzig, Liebigstrasse 26, Leipzig, 04103, Germany
    Arch Gynecol Obstet 277:135-8. 2008
  9. ncbi request reprint Juxtatumoral desmoplastic stromal reaction is associated with high tumor cell dissociation in squamous cell carcinomas of the uterine cervix
    Lars Cristian Horn
    Institute of Pathology, University of Leipzig, D 04103 Leipzig, Germany
    Ann Diagn Pathol 10:253-6. 2006
  10. ncbi request reprint Pattern of invasion is of prognostic value in surgically treated cervical cancer patients
    L C Horn
    Institute of Pathology, Division of Gynecologic Pathology, University of Leipzig, Liebigstrasse 26, Leipzig, D 04103, Germany
    Gynecol Oncol 103:906-11. 2006

Detail Information

Publications77

  1. ncbi request reprint Histopathology of endometrial hyperplasia and endometrial carcinoma: an update
    Lars Christian Horn
    Division of Gynecologic Pathology, Institute of Pathology, Leipzig University, D 04103 Leipzig, Germany
    Ann Diagn Pathol 11:297-311. 2007
    ..Finally, a short practical description for the handling of surgical specimens from fractional curetting and hysterctomies is given...
  2. ncbi request reprint [Morphology of secondary ovarian tumors and metastases]
    L C Horn
    Abteilung Mamma, Gynäko and Perinatalpathologie, Institut fur Pathologie, Department für Diagnostik, Universitatsklinikum Leipzig AoR, Liebigstr 24, 04103, Leipzig, Deutschland
    Pathologe 35:336-47. 2014
    ..It is necessary to note that the correct diagnosis of ovarian metastases always needs interdisciplinary and multidisciplinary approaches. ..
  3. ncbi request reprint A cut-off value of 2 cm in tumor size is of prognostic value in surgically treated FIGO stage IB cervical cancer
    Lars Christian Horn
    Institute of Pathology, Division of Breast, Gynecologic and Perinatal Pathology, University of Leipzig, Germany Electronic address
    Gynecol Oncol 134:42-6. 2014
    ..Limited knowledge exists about the value of tumor size in surgically treated cervical cancer (CX) using a tumor size of 2 cm as cut-off value...
  4. doi request reprint CD34(low) and SMA(high) represent stromal signature in uterine cervical cancer and are markers for peritumoral stromal remodeling
    Lars Christian Horn
    Institute of Pathology, Division of Breast, Gynecologic and Perinatal Pathology, University of Leipzig, Leipzig, Germany Electronic address
    Ann Diagn Pathol 17:531-5. 2013
    ..9 vs 81.0%; P=0.025 and 64.6 vs 81.1%; P=0.243). Peritumoral stromal response in cervical carcinoma is immunohistochemically characterized by CD34(low)/SMA(high) and associated reduced overall survival...
  5. doi request reprint Serous tubal in situ carcinoma (STIC) in primary peritoneal serous carcinomas
    Lars Christian Horn
    Division of Breast, Gynecologic and Perinatal Pathology, Institute of Trier, University of Leipzig, Leipzig, Germany
    Int J Gynecol Pathol 32:339-44. 2013
    ..There might be the 2 different carcinogenetic pathways within PPC, and further studies are required to identify the source of serous cancer in cases without an STIC lesion...
  6. ncbi request reprint Peritumoral stromal remodeling, pattern of invasion and expression of c-met/HGF in advanced squamous cell carcinoma of the cervix uteri, FIGO stages III and IV
    L C Horn
    Institute of Pathology, Division of Breast, Gynecologic and Perinatal Pathology, University of Leipzig, Leipzig, Germany
    Eur J Obstet Gynecol Reprod Biol 163:76-80. 2012
    ..This study evaluates the association between different PI, peritumoral DSR and its correlation to the expression of c-met/HGF in squamous cell carcinomas of the uterine cervix (CX)...
  7. doi request reprint c-kit/CD 117 positive cells in the myometrium of pregnant women and those with uterine endometriosis
    L C Horn
    Institute of Pathology, University of Leipzig, Germany
    Arch Gynecol Obstet 286:105-7. 2012
    ..Abnormal myometrial motility may play a role in the pathogenesis of endometriosis. Uterine contractility is a major contribution to labour. Myometrial motility might be controlled by CD 117-positive uterine smooth muscle cells...
  8. ncbi request reprint COX-2 and Her-2/neu are overexpressed in Paget's disease of the vulva and the breast: results of a preliminary study
    Lars Christian Horn
    Institute of Pathology, Division of Gynecologic and Perinatal Pathology, University of Leipzig, Liebigstrasse 26, Leipzig, 04103, Germany
    Arch Gynecol Obstet 277:135-8. 2008
    ..Recurrent disease after breast and vulvar surgery might be a challenge. To evaluate relevant molecules therapeutically, tissue from mammary and vulvar PD lesions was investigated immunohistochemically...
  9. ncbi request reprint Juxtatumoral desmoplastic stromal reaction is associated with high tumor cell dissociation in squamous cell carcinomas of the uterine cervix
    Lars Cristian Horn
    Institute of Pathology, University of Leipzig, D 04103 Leipzig, Germany
    Ann Diagn Pathol 10:253-6. 2006
    ..The intensity of DSR, as understood in the context of a remodeling of the juxtatumoral stroma to the infiltrative tumor growth, might be indicative of a highly dissociative tumor growth and is correlated to poorly differentiated tumors...
  10. ncbi request reprint Pattern of invasion is of prognostic value in surgically treated cervical cancer patients
    L C Horn
    Institute of Pathology, Division of Gynecologic Pathology, University of Leipzig, Liebigstrasse 26, Leipzig, D 04103, Germany
    Gynecol Oncol 103:906-11. 2006
    ..We evaluated the prognostic value of different patterns of invasion (PI) in cervical carcinomas (CX)...
  11. ncbi request reprint p16, p14, p53, cyclin D1, and steroid hormone receptor expression and human papillomaviruses analysis in primary squamous cell carcinoma of the endometrium
    Lars Christian Horn
    Institute of Pathology, University of Leipzig, D 04103 Leipzig, Germany
    Ann Diagn Pathol 10:193-6. 2006
    ..Factors known to play a pathogenetic role in types 1 and 2 of endometrial carcinomas are not associated with primary ESCC. However, prognostically, ESCCs are more related to type 1 cancers...
  12. doi request reprint Frozen section analysis of vulvectomy specimens: results of a 5-year study period
    Lars Christian Horn
    Institute of Pathology, Division of Breast, Gynecologic and Perinatal Pathology, University of Leipzig, Leipzig, Germany
    Int J Gynecol Pathol 29:165-72. 2010
    ..Therefore, all cutaneous vulvar resection margins, and the vaginal, urethral, and anal (mucosal) margin as well as the deep soft tissue margin should also be examined...
  13. ncbi request reprint Serous carcinoma of the endometrium with choriocarcinomatous differentiation: a case report and review of the literature indicate the existence of 2 prognostically relevant tumor types
    Lars Christian Horn
    Institute of Pathology and Division of Gynecologic Pathology, University of Leipzig, Leipzig, Germany
    Int J Gynecol Pathol 25:247-51. 2006
    ..The prognostically relevant component for long-time survival in the latter variant is the nontrophoblastic component...
  14. ncbi request reprint Umbilical cord hypercoiling and thinning: a rare cause of intrauterine death in the second trimester of pregnancy
    Lars Christian Horn
    Institute of Pathology, University Hospital of Leipzig, Leipzig, Germany
    Pediatr Dev Pathol 9:20-4. 2006
    ..Careful pathologic examination of the umbilical cord is recommended to detect TCS and to reduce the cases with unexplained intrauterine death...
  15. ncbi request reprint Mixed small cell carcinomas of the uterine cervix: prognostic impact of focal neuroendocrine differentiation but not of Ki-67 labeling index
    Lars Christian Horn
    Institute of Pathology, Division of Gynecologic Pathology, University of Leipzig, Germany
    Ann Diagn Pathol 10:140-3. 2006
    ..8% vs 70.8%; P < .001). Even a small SmCC component in mixed carcinomas of the uterine cervix was associated with adverse outcome. Proliferative activity, determined by Ki-67 labeling index, is of no prognostic value...
  16. ncbi request reprint p16, p14, p53, and cyclin D1 expression and HPV analysis in small cell carcinomas of the uterine cervix
    Lars Christian Horn
    Institute of Pathology, Division of Gynecopathology, and Department of Obstetrics and Gynecology, University of Leipzig, Leipzig, Germany
    Int J Gynecol Pathol 25:182-6. 2006
    ..p14 inactivation is of high prevalence in SmCCs and detection rate of p53 is similar to other histologic types of cervical carcinomas...
  17. ncbi request reprint Clinicopathologic characteristics and subsequent pregnancy outcome in 139 complete hydatidiform moles
    L C Horn
    Institute of Pathology, Division of Perinatal and Gynecologic Pathology, Leipzig University, Germany
    Eur J Obstet Gynecol Reprod Biol 128:10-4. 2006
    ..The most common form of gestational trophoblastic disease is the complete hydatidiform mole (CHM). The study reports our experience of clinicopathologic characteristics and subsequent pregnancy outcome of patients with CHM...
  18. ncbi request reprint Extracapsular extension of pelvic lymph node metastases is of prognostic value in carcinoma of the cervix uteri
    Lars Christian Horn
    Institute of Pathology, Division of Gynecologic Pathology, University Leipzig, Liebigstrasse 26, Leipzig, D 04103, Germany
    Gynecol Oncol 108:63-7. 2008
    ..Pelvic lymph node involvement is a well-recognized prognostic factor in cervical carcinoma (CX). Limited knowledge exists about extranodal extension of the tumor outside the lymph node capsule, i.e. extracapsular spread (ECS)...
  19. doi request reprint Mixed serous carcinoma of the endometrium with trophoblastic differentiation: analysis of the p53 tumor suppressor gene suggests stem cell origin
    Lars Christian Horn
    Institute of Pathology, University of Leipzig, D 04103 Leipzig, Germany
    Ann Diagn Pathol 12:1-3. 2008
    ..These alterations suggest that the multidirectional tumor differentiation might occur from a common stem cell in these malignancies...
  20. doi request reprint [HPV-associated alterations of the vulva and vagina. Morphology and molecular pathology]
    L C Horn
    Abteilung Mamma, Gynäko and Perinatalpathologie, Institut fur Pathologie, Zemtrum für Diagnostik, Universitatsklinikum Leipzig, Liebigstr 26, 04103, Leipzig, Deutschland
    Pathologe 32:467-75. 2011
    ....
  21. doi request reprint [Precancerous lesions of the uterine cervix: morphology and molecular pathology]
    L C Horn
    Institut fur Pathologie, Abteilung Mamma, Gynäko and Perinatalpathologie, Department für Diagnostik, Universitatsklinikum Leipzig, Liebigstr 26, 04103, Leipzig, Deutschland
    Pathologe 32:242-54. 2011
    ....
  22. doi request reprint [Changes in the TNM classification of gynecological tumors]
    L C Horn
    Institut fur Pathologie, Universitatsklinikum Leipzig, Liebigstr 26, 04103, Leipzig, Deutschland
    Pathologe 31:367-73. 2010
    ..In endometrial cancer, the previous pT1a and pT1b were merged to pT1a. The former category T1c has changed into T1b. The category pT1c is no longer used. For the first time, there is a TNM classification system for uterine sarcomas...
  23. doi request reprint Perineural invasion in carcinoma of the cervix uteri--prognostic impact
    Lars Christian Horn
    Division of Breast Gynecologic and Perinatal Pathology, Institute of Pathology, University of Leipzig, Liebigstrasse 26, 04103 Leipzig, Germany
    J Cancer Res Clin Oncol 136:1557-62. 2010
    ..Limited information exists about the occurrence and the impact of perineural invasion (PNI) in patients with cervical carcinoma (CX)...
  24. doi request reprint [Current TNM/FIGO classification for cervical and endometrial cancer as well as malignant mixed müllerian tumors. Facts and background]
    L C Horn
    Abteilung Mamma, Gynäko and Perinatalpathologie, Institut fur Pathologie, Universitat Leipzig, Liebigstr 26, 04103, Leipzig
    Pathologe 32:239-43. 2011
    ..In the TNM system, regional lymph node involvement can alternatively be classified as N1. The MMMT will be staged like endometrial carcinoma...
  25. doi request reprint Cyclooxygenase-2 expression, Ki-67 labeling index, and perifocal neovascularization in endometriotic lesions
    Lars Christian Horn
    Department of Breast, Gynecologic and Perinatal Pathology, Institute of Pathology, University of Leipzig, D 04103 Leipzig, Germany
    Ann Diagn Pathol 13:373-7. 2009
    ..Cyclooxygenase-2 inhibitors are of clinical interest as treatment options...
  26. ncbi request reprint [Histopathology of gestational trophoblastic disease. An update]
    L C Horn
    Abteilung Mamma, Gynäko and Perinatalpathologie, Institut fur Pathologie, Universitat Leipzig, Leipzig, Deutschland
    Pathologe 30:313-23. 2009
    ..Recent molecular data suggest a neoplastic transformation of (cyto-) trophoblastic stem cells, within the pathogenesis of (non-villous) GTD. The detection of target molecules for a targeted therapy is currently irrelevant...
  27. ncbi request reprint [Carcinosarcomas (malignant mixed Mullerian tumors) of the uterus. Morphology, pathogenetic aspects and prognostic factors]
    L C Horn
    Institut fur Pathologie, Abteilung Mamma, Gynäko and Perinatalpathologie, Universitat Leipzig, Leipzig, Deutschland
    Pathologe 30:292-301. 2009
    ..Clinical and pathologic staging should be performed as in endometrial carcinoma. The main differential diagnoses include uterine sarcomas, adenosarcoma and benign metaplastic change within the endometrium...
  28. doi request reprint [Pathoanatomical preparation and reporting of specimens from precancerous lesions and carcinomas of the vulva]
    L C Horn
    Abteilung Mamma, Gynäko and Perinatalpathologie, Institut fur Pathologie, Universitat Leipzig, Liebigstr 26, 04103, Leipzig, Deutschland
    Pathologe 30:56-64. 2009
    ..Tumor grade and the presence of lymphovascular space involvement are controversially discussed...
  29. doi request reprint Adenoid squamous carcinoma (pseudoangiosarcomatous carcinoma) of the vulva: a rare but highly aggressive variant of squamous cell carcinoma-report of a case and review of the literature
    Lars Christian Horn
    Institute of Pathology, Division of Gynecologic Pathology, Leipzig University, Leipzig, Germany
    Int J Gynecol Pathol 27:288-91. 2008
    ..However, further molecular studies are required...
  30. doi request reprint Application of tissue microarrays in placental research
    Lars Christian Horn
    Division of Gynecologic and Perintatal Pathology, Institute of Pathology, University of Leipzig, D 04103 Leipzig, Germany
    Ann Diagn Pathol 12:48-9. 2008
    ..Here we describe the technical details of the application of tissue microarray in placental research. Although the placenta represents a very inhomogeneous organ, this technique is also usable in placental research...
  31. ncbi request reprint Prognostic value of trophoblastic proliferation in complete hydatidiform moles in predicting persistent disease
    L C Horn
    Institute of Pathology, Division of Perinatal and Gynecologic Pathology, Leipzig University, Liebigstrasse 26, Leipzig D 04103, Germany
    Pathol Res Pract 202:151-6. 2006
    ..04), but not with the occurrence of metastatic disease. Histomorphology might predict the risk of persistent disease, indicating the necessity for closer a follow-up, but further studies are required...
  32. ncbi request reprint Occult tumor cells in pelvic lymph nodes and parametrial tissue of small-sized FIGO IB1 squamous cell carcinomas of the uterine cervix--results of a pilot study
    L C Horn
    Institute of Pathology, Division of Gynecologic Pathology, University of Leipzig, Liebigstrasse 26, Leipzig, D 04103, Germany
    Pathol Res Pract 201:513-6. 2005
    ....
  33. ncbi request reprint [Myxoid uterine leiomyoma with focal lymphangioma-like pattern]
    L C Horn
    Institut fur Pathologie, Universitat Leipzig
    Zentralbl Gynakol 123:655-8. 2001
    ..The lack of infiltrative growth patterns excluded myxoid leiomyosarcoma as the major differenzial diagnosis...
  34. ncbi request reprint Familial cancer history in patients with carcinoma of the cervix uteri
    Lars Christian Horn
    Institute of Pathology, Leipzig University, Liebigstrasse 26, D 04103 Leipzig, Germany
    Eur J Obstet Gynecol Reprod Biol 101:54-7. 2002
    ..Several cancers show the tendency to aggregate in families. But the contribution of heredity to the causation of sporadic malignancies, like cervical cancer is unclear...
  35. ncbi request reprint DNA cytometric analysis of surgically treated squamous cell cancer of the uterine cervix, stage pT1b1-pT2b
    Lars Christian Horn
    Institute of Pathology, Leipzig University, Germany
    Anal Quant Cytol Histol 24:23-9. 2002
    ..To determine the utility of DNA content and DNA-related variables of proliferative activity regarding prognosis in cervical cancer...
  36. ncbi request reprint [Recommendations for the oncologic pathology report and morphologic factors associated with prognosis in endometrial carcinoma]
    L C Horn
    Institut fur Pathologie, Gynäkopathologie, Universitat Leipzig, Germany
    Zentralbl Gynakol 124:36-44. 2002
    ..Well established prognostic factors are surgical tumor stage (pTNM-system), pelvic lymph node metastases and tumor grading. Molecular biologic and cellkinetic parameters should be used for research purpose only...
  37. ncbi request reprint [Gestational trophoblastic disease. Non-villous forms of gestational trophoblastic disease]
    L C Horn
    Institut fur Pathologie, Abteilung für Gynäkopathologie, Universitat Leipzig
    Pathologe 25:281-91. 2004
    ..The ETT consists large necrotic areas with hyalinisation. Typically small blood vessels with preserved walls are located within the center of glycogen-rich monomorphous proliferation of trophoblastic cells...
  38. ncbi request reprint Identification of the causes of intrauterine death during 310 consecutive autopsies
    Lars Christian Horn
    Institute of Pathology, University Hospital of Leipzig, Liebigstrasse 26, Leipzig D 04103, Germany
    Eur J Obstet Gynecol Reprod Biol 113:134-8. 2004
    ..Evaluation of causes of death in stillborn infants...
  39. ncbi request reprint Risk of progression in complex and atypical endometrial hyperplasia: clinicopathologic analysis in cases with and without progestogen treatment
    L C Horn
    Institute of Pathology Gynecopathology, University of Leipzig, Liebigstrasse 26, D 04103 Leipzig, Germany
    Int J Gynecol Cancer 14:348-53. 2004
    ..0001). Endometrial hyperplasia without atypia is likely to respond to hormonal treatment. Especially in postmenopausal situation, atypical hyperplasia should be treated with total hysterectomy...
  40. ncbi request reprint Histologic analysis of gonadal tissue in patients with Ullrich-Turner syndrome and derivative Y chromosomes
    L C Horn
    Institute of Pathology, Division of Perinatal and Gynecologic Pathology, University of Leipzig, Liebigstrasse 26, Leipzig D 04103, Germany
    Pediatr Dev Pathol 8:197-203. 2005
    ..Careful, complete processing, including step sectioning, of the gonadectomy specimens to detect small lesions is recommended...
  41. ncbi request reprint Intrinsic form of ureteral endometriosis causing ureteral obstruction and partial loss of kidney function
    L C Horn
    Institute of Pathology, Leipzig University, Leipzig, Germany
    Urol Int 73:181-4. 2004
    ..Urinary tract endometriosis is rare and occurs in about 1% of all endometriotic lesions. About 30% of patients suffer from reduced kidney function at the time of diagnosis...
  42. ncbi request reprint p53 in surgically treated and pathologically staged cervical cancer: correlation with local tumor progression, but not with lymphatic spread
    L C Horn
    Institute of Pathology, University Hospital of Leipzig, Germany
    Pathol Res Pract 197:605-9. 2001
    ..There is no correlation of p53-immunostaining with the occurrence of p53-gene mutations in cervical cancer...
  43. ncbi request reprint [Recommendations for the handling and oncologic pathology report of lymph node specimens submitted for evaluation of metastatic disease in gynecologic malignancies]
    L C Horn
    Abteilung für Gynäko and Perinatalpathologie, Institut für Pathologie der Universität Leipzig
    Pathologe 26:266-72. 2005
    ..In cases of metastatic disease and carcinoma of unknown primary (CUP-syndrome), information should be given regarding the primary tumor...
  44. ncbi request reprint [Cancer register for cervix carcinoma--useful and necessary?]
    L C Horn
    Institut fur Pathologie, Gynäkopathologie, Universitatsklinikum Leipzig
    Zentralbl Gynakol 123:311-4. 2001
    ..e. histopathology meets genomics...
  45. ncbi request reprint Endometrial metastasis from breast cancer in a patient receiving tamoxifen therapy
    L C Horn
    Institute of Pathology, Leipzig University, Leipzig, Germany
    Gynecol Obstet Invest 50:136-8. 2000
    ..However, clinicians should be aware of this possibility and provide patients receiving TAM therapy with close gynecologic follow-up using liberal indications for endometrial biopsies...
  46. ncbi request reprint [Pathoanatomical preparation and reporting for dysplasias and cancers of the cervix uteri: cervical biopsy, conization, radical hysterectomy and exenteration]
    L C Horn
    Abt für Gynäko and Perinatalpathologie, Institut fur Pathologie, Universitat, Liebigstrasse 26, 04103, Leipzig
    Pathologe 28:249-60. 2007
    ..The preparation of exenteration specimens is a highly skilled job: the exact tumor dimension should be given in its relation to all resected organs and structures with special focus on resection margins...
  47. ncbi request reprint Occult tumor cells in surgical specimens from cases of early cervical cancer treated by liposuction-assisted nerve-sparing radical hysterectomy
    L C Horn
    Institute of Pathology, Gynaecopathology, University of Leipzig, Germany
    Int J Gynecol Cancer 11:159-63. 2001
    ..We conclude that the LANS-RH technique is capable of resecting potentially tumor-bearing pelvic tissue. Careful histologic handling and immunohistochemical techniques may improve the detection of OTCD...
  48. ncbi request reprint [Epidemiology and pathogenesis of cervical cancer]
    U Fischer
    Universitäts Frauenklinik Leipzig
    Zentralbl Gynakol 123:198-205. 2001
    ..Both, CIN and ACIS represents proliferative active lesions, caused by infection with HPV. But the detection of morphologic alterations, associated with HPV, like koilocytes, are inverse correlated with the grade of the CIN-lesion...
  49. ncbi request reprint [Histopathological prognostic factors in primary surgically treated cervix carcinoma]
    L C Horn
    Institut fur Pathologie, Gynäkopathologie, Universitatsklinikum Leipzig
    Zentralbl Gynakol 123:266-74. 2001
    ....
  50. ncbi request reprint [Pathologic-anatomic description and basic morphological information for management of dysplasias and carcinomas of the cervix uteri]
    L C Horn
    Institut fur Pathologie, Gynäkopathologie, Universitatsklinikum Leipzig
    Zentralbl Gynakol 123:255-65. 2001
    ..Konizations and LOOP-excision specimens should be processed completely in step sections. The pathology report must include the severity of CIN-lesion, changes caused by HPV-infection, according to colposcopic localisation...
  51. ncbi request reprint CD44-v6 concentrations in carcinoma of the uterine cervix: lack of prognostic significance
    L C Horn
    Institute of Pathology Division of Gynecologic Pathology, University of Leipzig, Liebigstrasse 26, Leipzig, 04103, Germany
    Arch Gynecol Obstet 273:104-6. 2005
    ..81). The CD 44-v6 concentration was not informative regarding recurrence-free and overall survival. Contrary to immunohistochemistry, the quantification of CD 44-v6 using ELISA-technique does not provide any further information...
  52. ncbi request reprint Hormone replacement therapy (HRT) and endometrial morphology under consideration of the different molecular pathways in endometrial carcinogenesis
    Lars Christian Horn
    Institute of Pathology, Division of Gynecologic Pathology, University of Leipzig, Liebigstrasse 26, Leipzig D 04103, Germany
    Eur J Obstet Gynecol Reprod Biol 122:4-12. 2005
    ..The use of tibolone leaves the endometrium unaffected...
  53. ncbi request reprint Expression of COX-2 and HER-2/neu and estrogen and progesterone receptor in primary squamous cell carcinomas of the endometrium
    L C Horn
    Institute of Pathology, University of Leipzig, Liebigstrasse 26, 04103 Leipzig, Germany
    J Cancer Res Clin Oncol 131:226-8. 2005
    ..Primary endometrial squamous cell carcinoma (ESCC) are rare but aggressive malignancies. To evaluate therapeutically relevant molecules, ESCC were investigated immunohistochemically...
  54. ncbi request reprint Evaluation of the invasion front pattern of squamous cell cervical carcinoma by measuring classical and discrete compactness
    Jens Einenkel
    Department of Obstetrics and Gynecology, Leipzig University, Germany
    Comput Med Imaging Graph 31:428-35. 2007
    ..033). We conclude that the discrete compactness C(D) is a new and reproducible parameter for a computer assisted quantification of the invasion front pattern and, thus, defines a further phenotypic feature of SCC of the uterine cervix...
  55. ncbi request reprint Smooth muscle cells from human urinary bladder express connexin 43 in vivo and in vitro
    Jochen Neuhaus
    Department of Urology, University of Leipzig AöR, Stephanstr 11, 04103 Leipzig, Germany
    World J Urol 20:250-4. 2002
    ..Our findings support the notion that Cx 43 is constitutively expressed in human bladder SMC in vivo. Thus, the function of the bladder is likely to be influenced by the organisation of smooth muscle cells into functional syncytia...
  56. ncbi request reprint Diversity of CD97 in smooth muscle cells
    Gabriela Aust
    Department of Surgery, Faculty of Medicine Research Laboratories, Center of Surgery, University of Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany
    Cell Tissue Res 324:139-47. 2006
    ..Thus, CD97 showed variable expression in vascular and biochemical modification in tumorigenic SMC, suggesting that the function of the molecule is specific for the SMC subtype...
  57. ncbi request reprint Anatomical landmarks of radical prostatecomy
    Jens Uwe Stolzenburg
    Department of Urology, University of Leipzig, Leipzig, Germany
    Eur Urol 51:629-39. 2007
    ..In the present study, we review current literature and based on our experience, we present the anatomical landmarks of open and laparoscopic/endoscopic radical prostatectomy...
  58. ncbi request reprint Expression of erythropoietin and erythropoietin receptor in cervical cancer and relationship to survival, hypoxia, and apoptosis
    Cornelia Leo
    Department of Gynecology, Leipzig University, Leipzig, Germany
    Clin Cancer Res 12:6894-900. 2006
    ....
  59. ncbi request reprint Tumor hypoxia and expression of c-met in cervical cancer
    Cornelia Leo
    Department of Gynecology, Leipzig University, Philipp Rosenthal Strasse 55, 04103 Leipzig, Germany
    Gynecol Oncol 104:181-5. 2007
    ..The aim of this study, therefore, was to investigate the expression of the c-met protooncogene in cervical cancers in relation to intratumoral hypoxia levels and to clinico-pathological parameters...
  60. ncbi request reprint Alterations in connexin expression in the bladder of patients with urge symptoms
    Jochen Neuhaus
    Department of Urology, Clinic for Urology, University of Leipzig, Leipzig, Germany
    BJU Int 96:670-6. 2005
    ....
  61. ncbi request reprint Expression of Apaf-1 in cervical cancer correlates with lymph node metastasis but not with intratumoral hypoxia
    Cornelia Leo
    Department of Gynecology, Leipzig University, Philipp Rosenthal Strasse 55, 04103 Leipzig, Germany
    Gynecol Oncol 97:602-6. 2005
    ..The aim of this study was to investigate the expression of the proapoptotic protein Apaf-1 in cervical cancers. Moreover, we studied its correlation to intratumoral pO(2) and to clinico-pathological parameters...
  62. ncbi request reprint Association between the mesenchymal compartment of uterovaginal organogenesis and local tumour spread in stage IB-IIB cervical carcinoma: a prospective study
    Michael Hockel
    Department of Obstetrics and Gynaecology, University of Leipzig, Leipzig, Germany
    Lancet Oncol 6:751-6. 2005
    ..We aimed to define such a morphogenetic unit in Müllerian development, and to assess the role of total mesometrial resection in the treatment of patients with stage IB-IIB cervical carcinoma...
  63. ncbi request reprint Three-dimensional reconstruction and quantification of cervical carcinoma invasion fronts from histological serial sections
    Ulf Dietrich Braumann
    Interdisciplinary Center for Bioinformatics, University Leipzig, Leipzig, Germany
    IEEE Trans Med Imaging 24:1286-307. 2005
    ..By this, we achieved the most detailed 3-D reconstruction of the invasion of solid tumors so far. Once reconstructed, the invasion front of the segmented tumor is quantified using discrete compactness...
  64. ncbi request reprint Lack of apoptotic protease activating factor-1 expression and resistance to hypoxia-induced apoptosis in cervical cancer
    Cornelia Leo
    Department of Gynecology, Leipzig University, Leipzig, Germany
    Clin Cancer Res 13:1149-53. 2007
    ..Furthermore, the effect of hypoxia and apoptosis on survival was examined...
  65. ncbi request reprint Clonal history of papillomavirus-induced dysplasia in the female lower genital tract
    Svetlana Vinokurova
    Department of Molecular Pathology Applied Tumor Biology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    J Natl Cancer Inst 97:1816-21. 2005
    ....
  66. ncbi request reprint The status of cyclooxygenase-2 expression in ductal carcinoma in situ lesions and invasive breast cancer correlates to cyclooxygenase-2 expression in normal breast tissue
    Cornelia Leo
    Department of Gynecology, Leipzig University, 04103 Leipzig, Germany
    Ann Diagn Pathol 10:327-32. 2006
    ..The aim of this study, therefore, was to investigate COX-2 protein expression in normal breast tissue, DCIS, and invasive breast cancer in samples from the same patients...
  67. ncbi request reprint Combined three-dimensional microscopic visualisation of tumour-invasion front of cervical carcinoma
    Jens Einenkel
    Department of Obstetrics and Gynaecology, University of Leipzig, Leipzig, Germany
    Lancet Oncol 7:698. 2006
  68. doi request reprint Immunostaining for p16INK4a used as a conjunctive tool improves interobserver agreement of the histologic diagnosis of cervical intraepithelial neoplasia
    Lars Christian Horn
    Institute of Pathology, University of Leipzig, Germany
    Am J Surg Pathol 32:502-12. 2008
    ....
  69. ncbi request reprint 3-D analysis of the invasion front in squamous cell carcinoma of the uterine cervix: histopathologic evidence for collective invasion per continuitatem
    Jens Einenkel
    Department of Obstetrics and Gynecology, Interdisciplinary Center for Bioinformatics, Institute of Pathology, University Leipzig, Leipzig, Germany
    Anal Quant Cytol Histol 29:279-90. 2007
    ..To investigate spatial tumor invasion using ex vivo specimens and pursue a new morphometric approach for a quantitative assessment of the invasion front...
  70. ncbi request reprint Chorioamnionitis-induced changes of fetal extramedullar hematopoiesis in the second trimester of gestation. Is diagnosis from fetal autopsy possible?
    Cora Pfisterer
    Department of Obstetrics and Gynecology, University Hospital of Leipzig, Philipp Rosenthal Strasse 55, 04103, Leipzig, Germany
    Virchows Arch 446:150-6. 2005
    ..The morphology of fetal intrahepatic hematopoiesis and iron storing might also be helpful in the diagnosis of chorioamnionitis, especially when the placenta is not available for examination...
  71. ncbi request reprint Combined serial section-based 3D reconstruction of cervical carcinoma invasion using H&E/p16INK4a/CD3 alternate staining
    Nicolas Wentzensen
    Division for Applied Tumor Biology, Institute of Pathology, University Heidelberg, 69120 Heidelberg, Germany
    Cytometry A 71:327-33. 2007
    ..The present study analyzes the spatial organization of a cervical cancer and the relation of the tumor invasion front and the infiltration with CD3(+) T-cells...
  72. ncbi request reprint A misdiagnosed case of caesarean scar pregnancy
    Jens Einenkel
    Department of Obstetrics and Gynaecology, University of Leipzig, Philipp Rosenthal Strasse 55, 04103 Leipzig, Germany
    Arch Gynecol Obstet 271:178-81. 2005
    ..For the first time, a strongly vascularised pelvic tumour developed while the titre of serum human chorionic gonadotrophin decreased after a curettage abortion for an unwanted pregnancy...
  73. ncbi request reprint Lack of hypoxic response in uterine leiomyomas despite severe tissue hypoxia
    Arnulf Mayer
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Mainz, Germany
    Cancer Res 68:4719-26. 2008
    ..Malignancy in the same organ system is associated with growth and metabolism beyond tissue-inherent limitations leading to the induction of hypoxia-related markers, thereby contributing to a self-perpetuating aggressive phenotype...
  74. ncbi request reprint Unrealistic expectations for IR microspectroscopic imaging
    Jens Einenkel
    Nat Biotechnol 25:29-31; author reply 31-3. 2007
  75. ncbi request reprint Androgen receptors are frequently expressed in mammary and extramammary Paget's disease
    Bernadette Liegl
    Department of Pathology, Medical University of Graz, Graz, Austria
    Mod Pathol 18:1283-8. 2005
    ..The knowledge about frequent expression of AR in Paget's disease could lead to the development of a new adjuvant therapy, particularly in patients with recurrent disease...
  76. ncbi request reprint Delimitation of squamous cell cervical carcinoma using infrared microspectroscopic imaging
    Wolfram Steller
    Institute for Analytical Chemistry, Dresden University of Technology, 01062, Dresden, Germany
    Anal Bioanal Chem 384:145-54. 2006
    ....
  77. ncbi request reprint pRb, p16, and cyclin D1 in small cell carcinoma of the uterine cervix
    Lars Christian Horn
    Int J Gynecol Pathol 26:269. 2007