Sven Horke


Affiliation: University of Mainz
Country: Germany


  1. request reprint
    Horke S, Witte I, Wilgenbus P, Krüger M, Strand D, Förstermann U. Paraoxonase-2 reduces oxidative stress in vascular cells and decreases endoplasmic reticulum stress-induced caspase activation. Circulation. 2007;115:2055-64 pubmed
    ..We suggest that PON2 represents an endogenous defense mechanism against vascular oxidative stress and unfolded protein response-induced cell death, thereby contributing to the prevention of atherosclerosis. ..
  2. Ebert J, Wilgenbus P, Teiber J, Jurk K, Schwierczek K, Döhrmann M, et al. Paraoxonase-2 regulates coagulation activation through endothelial tissue factor. Blood. 2018;: pubmed publisher
    ..These experiments delineate a PON2 redox-dependent mechanism that regulates endothelial cell TF activity and prevents systemic coagulation activation and inflammation. ..
  3. Horke S, Witte I, Wilgenbus P, Altenhöfer S, Krüger M, Li H, et al. Protective effect of paraoxonase-2 against endoplasmic reticulum stress-induced apoptosis is lost upon disturbance of calcium homoeostasis. Biochem J. 2008;416:395-405 pubmed publisher