Thorsten Hoppe

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. ncbi request reprint Multiubiquitylation by E4 enzymes: 'one size' doesn't fit all
    Thorsten Hoppe
    Centre for Molecular Neurobiology ZMNH, University of Hamburg, Falkenried 94, 20251 Hamburg, Germany
    Trends Biochem Sci 30:183-7. 2005
  2. doi request reprint The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis
    Kirsten Kuhlbrodt
    Centre for Molecular Neurobiology ZMNH, University of Hamburg, Falkenried 94, 20251 Hamburg, Germany
    Nat Cell Biol 13:273-81. 2011
  3. ncbi request reprint The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathy
    Philipp Christoph Janiesch
    Centre for Molecular Neurobiology ZMNH, University of Hamburg, Falkenried 94, 20251 Hamburg, Germany
    Nat Cell Biol 9:379-90. 2007
  4. pmc Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication
    Julien Mouysset
    Centre for Molecular Neurobiology ZMNH, University of Hamburg, Falkenried 94, 20251 Hamburg, Germany
    Proc Natl Acad Sci U S A 105:12879-84. 2008
  5. doi request reprint Protein quality control gets muscle into shape
    Johnny Kim
    Centre for Molecular Neurobiology ZMNH, University of Hamburg, Falkenried 94, 20251 Hamburg, Germany
    Trends Cell Biol 18:264-72. 2008
  6. ncbi request reprint The ubiquitin-selective chaperone CDC-48/p97, a new player in DNA replication
    Alexandra Deichsel
    Centre for Molecular Neurobiology ZMNH, University of Hamburg, Hamburg, Germany
    Cell Cycle 8:185-90. 2009
  7. ncbi request reprint Orchestra for assembly and fate of polyubiquitin chains
    Kirsten Kuhlbrodt
    Centre for Molecular Neurobiology ZMNH, University of Hamburg, Falkenried 94, 20251 Hamburg, Germany
    Essays Biochem 41:1-14. 2005
  8. ncbi request reprint A conserved role of Caenorhabditis elegans CDC-48 in ER-associated protein degradation
    Julien Mouysset
    Centre for Molecular Neurobiology, ZMNH, University of Hamburg, Falkenried 94, 20251 Hamburg, Germany
    J Struct Biol 156:41-9. 2006
  9. pmc Think locally: control of ubiquitin-dependent protein degradation in neurons
    Alexandra Segref
    Centre for Molecular Neurobiology, ZMNH, University of Hamburg, Hamburg, Germany
    EMBO Rep 10:44-50. 2009
  10. ncbi request reprint Regulation of the myosin-directed chaperone UNC-45 by a novel E3/E4-multiubiquitylation complex in C. elegans
    Thorsten Hoppe
    Department of Molecular Neurogenetics, Adolph Butenandt Institute, Ludwig Maximilians University, Schillerstrasse 44, 80336 Munich, Germany
    Cell 118:337-49. 2004

Collaborators

  • Alexandra Segref
  • Carsten Hoege
  • Julien Mouysset
  • Kirsten Kuhlbrodt
  • Alexandra Deichsel
  • Philipp Christoph Janiesch
  • Johnny Kim
  • Roja Barikbin
  • Megan L Landsverk
  • Wolfdieter Springer
  • Eva Kevei
  • Thomas Lowe
  • Anthony A Hyman
  • Anton Gartner
  • Sandra Moser
  • Hanns Lochmuller
  • Ayaz Najafov
  • Giuseppe Cassata
  • Alex H Hutagalung
  • Shumin Li
  • Sabine Krause
  • Henry F Epstein
  • Jose M Barral
  • Christian K√§hler
  • Enrico Schmidt
  • Ralf Baumeister

Detail Information

Publications12

  1. ncbi request reprint Multiubiquitylation by E4 enzymes: 'one size' doesn't fit all
    Thorsten Hoppe
    Centre for Molecular Neurobiology ZMNH, University of Hamburg, Falkenried 94, 20251 Hamburg, Germany
    Trends Biochem Sci 30:183-7. 2005
    ..Recent studies have provided accumulating evidence that has led some researchers in the field to conclude that E4, indeed, represents a distinct and novel class of enzymes...
  2. doi request reprint The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis
    Kirsten Kuhlbrodt
    Centre for Molecular Neurobiology ZMNH, University of Hamburg, Falkenried 94, 20251 Hamburg, Germany
    Nat Cell Biol 13:273-81. 2011
    ....
  3. ncbi request reprint The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathy
    Philipp Christoph Janiesch
    Centre for Molecular Neurobiology ZMNH, University of Hamburg, Falkenried 94, 20251 Hamburg, Germany
    Nat Cell Biol 9:379-90. 2007
    ....
  4. pmc Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication
    Julien Mouysset
    Centre for Molecular Neurobiology ZMNH, University of Hamburg, Falkenried 94, 20251 Hamburg, Germany
    Proc Natl Acad Sci U S A 105:12879-84. 2008
    ..Our findings identified a role for CDC-48(UFD-1/NPL-4) in DNA replication, which is important for cell cycle progression and genome stability...
  5. doi request reprint Protein quality control gets muscle into shape
    Johnny Kim
    Centre for Molecular Neurobiology ZMNH, University of Hamburg, Falkenried 94, 20251 Hamburg, Germany
    Trends Cell Biol 18:264-72. 2008
    ..Here, we highlight the interplay between chaperone activity and protein degradation in respect to the formation and maintenance of muscle during physiological and pathological conditions...
  6. ncbi request reprint The ubiquitin-selective chaperone CDC-48/p97, a new player in DNA replication
    Alexandra Deichsel
    Centre for Molecular Neurobiology ZMNH, University of Hamburg, Hamburg, Germany
    Cell Cycle 8:185-90. 2009
    ..Here, we speculate on the function of CDC-48 (also known as Cdc48p in yeast and p97 in vertebrates) during DNA replication initiation, addressing its ubiquitin-selective chaperone activity...
  7. ncbi request reprint Orchestra for assembly and fate of polyubiquitin chains
    Kirsten Kuhlbrodt
    Centre for Molecular Neurobiology ZMNH, University of Hamburg, Falkenried 94, 20251 Hamburg, Germany
    Essays Biochem 41:1-14. 2005
    ..Here we propose a model in which E4-dependent polyubiquitination pathways are modulated by different ubiquitin-binding proteins, using ataxin-3 as an example...
  8. ncbi request reprint A conserved role of Caenorhabditis elegans CDC-48 in ER-associated protein degradation
    Julien Mouysset
    Centre for Molecular Neurobiology, ZMNH, University of Hamburg, Falkenried 94, 20251 Hamburg, Germany
    J Struct Biol 156:41-9. 2006
    ..Together, these data suggest an evolutionarily conserved retro-translocation machinery at the endoplasmic reticulum...
  9. pmc Think locally: control of ubiquitin-dependent protein degradation in neurons
    Alexandra Segref
    Centre for Molecular Neurobiology, ZMNH, University of Hamburg, Hamburg, Germany
    EMBO Rep 10:44-50. 2009
    ....
  10. ncbi request reprint Regulation of the myosin-directed chaperone UNC-45 by a novel E3/E4-multiubiquitylation complex in C. elegans
    Thorsten Hoppe
    Department of Molecular Neurogenetics, Adolph Butenandt Institute, Ludwig Maximilians University, Schillerstrasse 44, 80336 Munich, Germany
    Cell 118:337-49. 2004
    ..These results identify CHN-1 and UFD-2 as a functional E3/E4 complex and UNC-45 as its physiologically relevant substrate...
  11. ncbi request reprint A Caenorhabditis elegans Parkin mutant with altered solubility couples alpha-synuclein aggregation to proteotoxic stress
    Wolfdieter Springer
    ABI Molecular Neurogenetics, University of Munich, Germany
    Hum Mol Genet 14:3407-23. 2005
    ..Due to high-throughput capacity of C. elegans, this model is particularly well suited to identify genetic and chemical modifiers of toxicity...
  12. pmc The UNC-45 chaperone mediates sarcomere assembly through myosin degradation in Caenorhabditis elegans
    Megan L Landsverk
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Cell Biol 177:205-10. 2007
    ..These findings suggest a mechanism in which UNC-45-related proteins may contribute to the degradation of myosin in conditions such as heart failure and muscle wasting...