Research Topics
Genomes and Genes | Stefan HoningSummaryAffiliation: University of Cologne Country: Germany Publications
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Publications
Phosphatidylinositol-(4,5)-bisphosphate regulates sorting signal recognition by the clathrin-associated adaptor complex AP2Stefan Honing
Institute for Biochemistry II, University of Gottingen, Heinrich Düker Weg 12, 37073 Gottingen, Germany
Mol Cell 18:519-31. 2005..The binding of AP2 to acidic-dileucine motifs occurs at a different site from Yxxvarphi binding and is not enhanced by mu2Thr156 phosphorylation...- AP-1 and AP-3 mediate sorting of melanosomal and lysosomal membrane proteins into distinct post-Golgi trafficking pathwaysBjörn Chapuy
Institute of Biochemistry II, Department of Hematology and Oncology, University of Gottingen, Heinrich Düker Weg 12, 37073 Gottingen, Germany
Traffic 9:1157-72. 2008.... - Phosphorylation of the AP2 mu subunit by AAK1 mediates high affinity binding to membrane protein sorting signalsDoris Ricotta
Institute for Biochemistry II, University of Gottingen, 37073 Gottingen, Germany
J Cell Biol 156:791-5. 2002..We propose that phosphorylation of the AP2 mu 2 subunit by AAK1 ensures high affinity binding of AP2 to sorting signals of cargo membrane proteins during the initial steps of receptor-mediated endocytosis... - TIP47 functions in the biogenesis of lipid dropletsAnna V Bulankina
Institute for Biochemistry II, University of Gottingen, 37073 Gottingen, Germany
J Cell Biol 185:641-55. 2009..Suppression of TIP47 blocked LD maturation and decreased the incorporation of triacylglycerol into LDs. We conclude that TIP47 functions in the biogenesis of LDs... - The tyrosine motifs of Lamp 1 and LAP determine their direct and indirect targetting to lysosomesStefanie Obermuller
Institute for Biochemistry II, University of Gottingen, Heinrich Düker Weg 12, 37073 Gottingen, Germany
J Cell Sci 115:185-94. 2002..In conclusion, the residues +2 and +3 of the tyrosine motifs determine the sorting of Lamp 1 and LAP in endosomes, mediating either the direct or the indirect pathway to lysosomes... - Beta-arrestin binding to CC chemokine receptor 5 requires multiple C-terminal receptor phosphorylation sites and involves a conserved Asp-Arg-Tyr sequence motifFriederike Huttenrauch
Department of Immunology, University of Gottingen, Kreuzbergring 57, 37075 Gottingen, Germany
J Biol Chem 277:30769-77. 2002..These results suggest that a conserved sequence motif within the second intracellular loop of CCR5 that is known to be involved in G protein activation plays a significant role in beta-arrestin binding to CCR5... - Granzyme-mediated cytotoxicity does not involve the mannose 6-phosphate receptors on target cellsRalf Dressel
Division of Immunogenetics, University of Gottingen, Heinrich Düker Weg 12, 37073 Gottingen, Germany
J Biol Chem 279:20200-10. 2004..In conclusion, these results strongly argue against an Mpr300- or Mpr46-dependent pathway of granzyme-mediated killing and provide new insight in the internalization of monomeric and complexed granzyme B... - Deficiency of UDP-galactose:N-acetylglucosamine beta-1,4-galactosyltransferase I causes the congenital disorder of glycosylation type IIdBengt Hansske
Abteilung Biochemie II, Georg August Universitat Gottingen, Heinrich Düker Weg 12, D 37073 Gottingen, Germany
J Clin Invest 109:725-33. 2002..The patient was homozygous and his parents heterozygous for this mutation. Expression of a corresponding mutant cDNA in COS-7 cells led to the synthesis of a truncated, inactive polypeptide, which localized to the endoplasmic reticulum... - Arabidopsis mu A-adaptin interacts with the tyrosine motif of the vacuolar sorting receptor VSR-PS1Nicole Happel
Institute for Biochemistry and Molecular Cell Biology, , , Germany
Plant J 37:678-93. 2004..The trans-Golgi localization of the mu A-adaptin strongly suggests its involvement in Golgi- to vacuole-trafficking events...