Carsten Holzmann

Summary

Affiliation: Universitaetzmedizin Rostock
Location: Rostock, Germany
URL: http://www.genetik.med.uni-rostock.de/

Publications

  1. ncbi request reprint Selective striatal neuron loss and alterations in behavior correlate with impaired striatal function in Huntington's disease transgenic rats
    Orsolya Kántor
    Department of Anatomy and Cell Biology, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany
    Neurobiol Dis 22:538-47. 2006
  2. ncbi request reprint Expression mapping of tetracycline-responsive prion protein promoter: digital atlasing for generating cell-specific disease models
    Jana Boy
    Department of Medical Genetics, University of Tubingen, Tubingen, Germany
    Neuroimage 33:449-62. 2006
  3. ncbi request reprint Behavioral abnormalities precede neuropathological markers in rats transgenic for Huntington's disease
    Huu Phuc Nguyen
    Department of Functional and Applied Anatomy, Medical School of Hannover, Germany
    Hum Mol Genet 15:3177-94. 2006
  4. doi request reprint Neurodegeneration and motor dysfunction in a conditional model of Parkinson's disease
    Silke Nuber
    Department of Medical Genetics, University of Tuebingen, D 72076 Tuebingen, Germany
    J Neurosci 28:2471-84. 2008
  5. doi request reprint Reversibility of symptoms in a conditional mouse model of spinocerebellar ataxia type 3
    Jana Boy
    Department of Medical Genetics, University of Tuebingen, Tuebingen, Germany
    Hum Mol Genet 18:4282-95. 2009
  6. doi request reprint A transgenic mouse model of spinocerebellar ataxia type 3 resembling late disease onset and gender-specific instability of CAG repeats
    Jana Boy
    Medical Genetics, University of Tuebingen, Tuebingen, Germany
    Neurobiol Dis 37:284-93. 2010
  7. doi request reprint Age-dependent gene expression profile and protein expression in a transgenic rat model of Huntington's disease
    Huu Phuc Nguyen
    Department of Medical Genetics, University of Tuebingen, Tuebingen, Germany
    Proteomics Clin Appl 2:1638-50. 2008
  8. doi request reprint Effects of intrastriatal botulinum neurotoxin A on the behavior of Wistar rats
    Carsten Holzmann
    Department of Medical Genetics, University of Rostock, Ernst Heydemann Str 8, 18057 Rostock, Germany
    Behav Brain Res 234:107-16. 2012
  9. ncbi request reprint Regional and subtype selective changes of neurotransmitter receptor density in a rat transgenic for the Huntington's disease mutation
    Andreas Bauer
    Institute of Medicine, Research Center Julich, Julich, Germany
    J Neurochem 94:639-50. 2005
  10. ncbi request reprint Extended mutation analysis and association studies of Nurr1 (NR4A2) in Parkinson disease
    R Hering
    Department of Medical Genetics, Hertie Institute of Clinical Brain Research, University of Tubingen, Germany
    Neurology 62:1231-2. 2004

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Selective striatal neuron loss and alterations in behavior correlate with impaired striatal function in Huntington's disease transgenic rats
    Orsolya Kántor
    Department of Anatomy and Cell Biology, RWTH Aachen University, Wendlingweg 2, 52074 Aachen, Germany
    Neurobiol Dis 22:538-47. 2006
    ..No alterations in mean total numbers of striatal neurons were found in 6-month-old animals. Testing 14-month-old animals in a choice reaction time task indicated impaired striatal function of tgHD rats compared with controls...
  2. ncbi request reprint Expression mapping of tetracycline-responsive prion protein promoter: digital atlasing for generating cell-specific disease models
    Jana Boy
    Department of Medical Genetics, University of Tubingen, Tubingen, Germany
    Neuroimage 33:449-62. 2006
    ..The study serves as a precursor for a database resource allowing evaluation of the suitability of different promoter mouse lines for generating disease models...
  3. ncbi request reprint Behavioral abnormalities precede neuropathological markers in rats transgenic for Huntington's disease
    Huu Phuc Nguyen
    Department of Functional and Applied Anatomy, Medical School of Hannover, Germany
    Hum Mol Genet 15:3177-94. 2006
    ..The dissociation of onset between behavioral and neuropathological markers is suggestive of as yet undetected processes, which contribute to the early phenotype of these HD transgenic rats...
  4. doi request reprint Neurodegeneration and motor dysfunction in a conditional model of Parkinson's disease
    Silke Nuber
    Department of Medical Genetics, University of Tuebingen, D 72076 Tuebingen, Germany
    J Neurosci 28:2471-84. 2008
    ..Furthermore, alpha-syn-associated cytotoxicity is independent of filamentous inclusion body formation in our conditional mouse model...
  5. doi request reprint Reversibility of symptoms in a conditional mouse model of spinocerebellar ataxia type 3
    Jana Boy
    Department of Medical Genetics, University of Tuebingen, Tuebingen, Germany
    Hum Mol Genet 18:4282-95. 2009
    ....
  6. doi request reprint A transgenic mouse model of spinocerebellar ataxia type 3 resembling late disease onset and gender-specific instability of CAG repeats
    Jana Boy
    Medical Genetics, University of Tuebingen, Tuebingen, Germany
    Neurobiol Dis 37:284-93. 2010
    ..Few and small intranuclear aggregates appeared first at the age of 18 months, further supporting the claim that neuronal dysfunction precedes the formation of intranuclear aggregates...
  7. doi request reprint Age-dependent gene expression profile and protein expression in a transgenic rat model of Huntington's disease
    Huu Phuc Nguyen
    Department of Medical Genetics, University of Tuebingen, Tuebingen, Germany
    Proteomics Clin Appl 2:1638-50. 2008
    ....
  8. doi request reprint Effects of intrastriatal botulinum neurotoxin A on the behavior of Wistar rats
    Carsten Holzmann
    Department of Medical Genetics, University of Rostock, Ernst Heydemann Str 8, 18057 Rostock, Germany
    Behav Brain Res 234:107-16. 2012
    ....
  9. ncbi request reprint Regional and subtype selective changes of neurotransmitter receptor density in a rat transgenic for the Huntington's disease mutation
    Andreas Bauer
    Institute of Medicine, Research Center Julich, Julich, Germany
    J Neurochem 94:639-50. 2005
    ..In particular, there is evidence for a contribution of predominantly presynaptically localized cholinergic and noradrenergic receptors in the response to Huntington's disease pathology...
  10. ncbi request reprint Extended mutation analysis and association studies of Nurr1 (NR4A2) in Parkinson disease
    R Hering
    Department of Medical Genetics, Hertie Institute of Clinical Brain Research, University of Tubingen, Germany
    Neurology 62:1231-2. 2004
  11. pmc Isolation and characterization of the rat huntingtin promoter
    C Holzmann
    Department of Molecular Human Genetics, Ruhr University Bochum, D 44780 Bochum, Germany
    Biochem J 336:227-34. 1998
    ..DNase I footprinting and electrophoretic mobility-shift assays were used to define the nucleotide positions and binding affinity of DNA-protein interactions...
  12. ncbi request reprint Functional characterization of the human Huntington's disease gene promoter
    C Holzmann
    Department of Medical Genetics, University Rostock, D 18055 Rostock, Germany
    Brain Res Mol Brain Res 92:85-97. 2001
    ..Binding affinities of DNA-protein interactions were defined by electrophoretic mobility shift assays and the protected nucleotide positions were determined by DNase I footprinting...
  13. ncbi request reprint Neurofilament L gene is not a genetic factor of sporadic and familial Parkinson's disease
    Nils Rahner
    Department of Medical Genetics, Children s Hospital, University Rostock, Rembrandt Strasse 16 17, 18055, Rostock, Germany
    Brain Res 951:82-6. 2002
    ..Association studies based on these haplotypes revealed no significant differences between PD patients and 344 control individuals. Therefore, NF-L is unlikely to play a major role in the pathogenesis of PD...
  14. ncbi request reprint 14-3-3 protein is a component of Lewy bodies in Parkinson's disease-mutation analysis and association studies of 14-3-3 eta
    Andreas Ubl
    Department of Medical Genetics, Children s Hospital, University Rostock, Rembrandt Str 16 17, Germany
    Brain Res Mol Brain Res 108:33-9. 2002
    ..In accordance with these findings, there was no staining of substantia nigra Lewy bodies with antibodies specific for the 14-3-3 eta subunit...
  15. ncbi request reprint Polymorphisms of the alpha-synuclein promoter: expression analyses and association studies in Parkinson's disease
    C Holzmann
    Department of Medical Genetics, University of Rostock, Federal Republic of Germany
    J Neural Transm 110:67-76. 2003
    ..The -668C/-116G haplotype revealed significant higher CAT expression than the -668T/-116G or the -668T/-116C haplotype, respectively. Although the -668C/-116G haplotype was more common in PD patients, this difference was not significant...
  16. ncbi request reprint Transgenic rat model of Huntington's disease
    Stephan von Horsten
    Department of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany
    Hum Mol Genet 12:617-24. 2003
    ..This model allows longitudinal in vivo imaging studies and is therefore ideally suited for the evaluation of novel therapeutic approaches such as neurotransplantation...
  17. ncbi request reprint Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease
    Frank P Marx
    Department of Neurology, Laboratory of Neurodegeneration, University of Tubingen, Tubingen, Germany
    Hum Mol Genet 12:1223-31. 2003
    ....
  18. ncbi request reprint 14-3-3 proteins in the nervous system
    Daniela Berg
    Institute for Human Genetics, Department of Medical Genetics, University of Tubingen, Calwerstrasse 7, 72076 Tubingen, Germany
    Nat Rev Neurosci 4:752-62. 2003