Frank G Holz

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi request reprint Intraocular microablation of choroidal tissue by a 308 nm AIDA excimer laser for RPE-transplantation in patients with age-related macular degeneration
    F G Holz
    Universitäts Augenklinik Heidelberg Im Neuenheimer Feld 400 D 69120 Heidelberg
    Biomed Tech (Berl) 48:82-5. 2003
  2. ncbi request reprint Visualization of retinal pigment epithelial cells in vivo using digital high-resolution confocal scanning laser ophthalmoscopy
    Almut Bindewald
    Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany
    Am J Ophthalmol 137:556-8. 2004
  3. ncbi request reprint [Pharmacological therapy for age-related macular degeneration. Current developments and perspectives]
    F G Holz
    Universitäts Augenklinik Heidelberg
    Ophthalmologe 100:97-103. 2003
  4. ncbi request reprint Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration
    F G Holz
    Department of Ophthalmology, University of Heidelberg, Germany
    Invest Ophthalmol Vis Sci 42:1051-6. 2001
  5. ncbi request reprint [Autofluorescence imaging of the macula]
    F G Holz
    Augenklinik der Ruprecht Karls Universität Heidelberg
    Ophthalmologe 98:10-8. 2001
  6. ncbi request reprint Combined intravitreal bevacizumab and photodynamic therapy for neovascular age-related macular degeneration
    Markus S Ladewig
    Department of Ophthalmology, University of Bonn, Ernst Abbe Strasse 2, 53127, Bonn, Germany
    Graefes Arch Clin Exp Ophthalmol 246:17-25. 2008
  7. doi request reprint Fundus autofluorescence in Pseudoxanthoma elasticum
    Robert P Finger
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Retina 29:1496-505. 2009
  8. doi request reprint Reading performance is reduced by parafoveal scotomas in patients with macular telangiectasia type 2
    Robert P Finger
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 50:1366-70. 2009
  9. doi request reprint Clinical evaluation of simultaneous confocal scanning laser ophthalmoscopy imaging combined with high-resolution, spectral-domain optical coherence tomography
    Hans Martin Helb
    Department of Ophthalmology, University of Bonn, Germany
    Acta Ophthalmol 88:842-9. 2010
  10. ncbi request reprint Correlation of macular function with retinal thickness in nonproliferative type 2 idiopathic macular telangiectasia
    Peter Charbel Issa
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Am J Ophthalmol 145:169-175. 2008

Detail Information

Publications123 found, 100 shown here

  1. ncbi request reprint Intraocular microablation of choroidal tissue by a 308 nm AIDA excimer laser for RPE-transplantation in patients with age-related macular degeneration
    F G Holz
    Universitäts Augenklinik Heidelberg Im Neuenheimer Feld 400 D 69120 Heidelberg
    Biomed Tech (Berl) 48:82-5. 2003
    ..In preclinical experiments we used a 308 nm UV AIDA excimer laser to microablate choroidal tissue from such a graft in human donor eyes...
  2. ncbi request reprint Visualization of retinal pigment epithelial cells in vivo using digital high-resolution confocal scanning laser ophthalmoscopy
    Almut Bindewald
    Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany
    Am J Ophthalmol 137:556-8. 2004
    ..To visualize retinal pigment epithelial cells in vivo by fundus autofluorescence imaging using a confocal scanning laser ophthalmoscope...
  3. ncbi request reprint [Pharmacological therapy for age-related macular degeneration. Current developments and perspectives]
    F G Holz
    Universitäts Augenklinik Heidelberg
    Ophthalmologe 100:97-103. 2003
    ..Other targets include the inhibition of toxic compound formation in lipofuscin granules such as AZ-E. What follows is an overview of different substances and their stages of development in clinical trials...
  4. ncbi request reprint Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration
    F G Holz
    Department of Ophthalmology, University of Heidelberg, Germany
    Invest Ophthalmol Vis Sci 42:1051-6. 2001
    ....
  5. ncbi request reprint [Autofluorescence imaging of the macula]
    F G Holz
    Augenklinik der Ruprecht Karls Universität Heidelberg
    Ophthalmologe 98:10-8. 2001
    ..Furthermore, identification of high-risk characteristics in patients with age-related macular degeneration with this technique may be helpful for indicating and adjusting future therapies...
  6. ncbi request reprint Combined intravitreal bevacizumab and photodynamic therapy for neovascular age-related macular degeneration
    Markus S Ladewig
    Department of Ophthalmology, University of Bonn, Ernst Abbe Strasse 2, 53127, Bonn, Germany
    Graefes Arch Clin Exp Ophthalmol 246:17-25. 2008
    ..Our aim was to evaluate the short-term safety and efficacy of combined photodynamic therapy (PDT) with verteporfin and intravitreal bevacizumab in neovascular age-related macular degeneration (AMD)...
  7. doi request reprint Fundus autofluorescence in Pseudoxanthoma elasticum
    Robert P Finger
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Retina 29:1496-505. 2009
    ..Changes in Bruch membrane lead to progressive atrophy of the retinal pigment epithelium (RPE), secondary CNVs, and visual loss. The RPE-photoreceptor complex was studied in vivo using fundus autofluorescence (FAF) imaging...
  8. doi request reprint Reading performance is reduced by parafoveal scotomas in patients with macular telangiectasia type 2
    Robert P Finger
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 50:1366-70. 2009
    ..In an investigation of their significance for reading performance, reading acuity and speed were measured and correlated with parafoveal sensitivity and fixation stability...
  9. doi request reprint Clinical evaluation of simultaneous confocal scanning laser ophthalmoscopy imaging combined with high-resolution, spectral-domain optical coherence tomography
    Hans Martin Helb
    Department of Ophthalmology, University of Bonn, Germany
    Acta Ophthalmol 88:842-9. 2010
    ....
  10. ncbi request reprint Correlation of macular function with retinal thickness in nonproliferative type 2 idiopathic macular telangiectasia
    Peter Charbel Issa
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Am J Ophthalmol 145:169-175. 2008
    ..To correlate macular thickness determined by optical coherence tomography (OCT) with light increment sensitivity and visual acuity in patients with type 2 idiopathic macular telangiectasia (IMT)...
  11. doi request reprint Metamorphopsia in patients with macular telangiectasia type 2
    Peter Charbel Issa
    Department of Ophthalmology, University of Bonn, Ernst Abbe Str 2, 53127, Bonn, Germany
    Doc Ophthalmol 119:133-40. 2009
    ..To assess metamorphopsia in patients with macular telangiectasia (MacTel) type 2...
  12. doi request reprint Long-term effectiveness of intravitreal bevacizumab for choroidal neovascularization secondary to angioid streaks in pseudoxanthoma elasticum
    Robert P Finger
    Department of Ophthalmology, University of Bonn, Germany
    Retina 31:1268-78. 2011
    ..To investigate the long-term effectiveness of intravitreal bevacizumab for treating active choroidal neovascularizations in pseudoxanthoma elasticum (PXE)...
  13. doi request reprint Correlation of lines of increased autofluorescence in macular dystrophy and pigmented paravenous retinochoroidal atrophy by optical coherence tomography
    Monika Fleckenstein
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Arch Ophthalmol 126:1461-3. 2008
  14. doi request reprint The impact of the severity of vision loss on vision-related quality of life in India: an evaluation of the IND-VFQ-33
    Robert P Finger
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 52:6081-8. 2011
    ..To validate the 33-item Indian Vision Functioning Questionnaire (IND-VFQ-33), a vision-specific scale, and determine the relationship between the severity of vision impairment (VI) and vision-related quality of life (VRQoL)...
  15. doi request reprint Abnormal macular pigment distribution in type 2 idiopathic macular telangiectasia
    Hans Martin Helb
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Retina 28:808-16. 2008
    ..To determine the distribution of macular pigment in type 2 idiopathic macular telangiectasia (IMT)...
  16. doi request reprint High-resolution spectral domain-OCT imaging in geographic atrophy associated with age-related macular degeneration
    Monika Fleckenstein
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 49:4137-44. 2008
    ..To describe morphologic variations in outer retinal layers in eyes with atrophic age-related macular degeneration (AMD) using high-resolution, spectral-domain optical coherence tomography (SD-OCT)...
  17. doi request reprint High-resolution optical coherence tomography of subpigment epithelial structures in patients with pigment epithelium detachment secondary to age-related macular degeneration
    Christoph R Clemens
    Department of Ophthalmology, University of Muenster, Muenster, Germany
    Br J Ophthalmol 96:1088-91. 2012
    ..Spectral domain optical coherence tomography (SD-OCT) allows for improved morphological characterisation of the space underneath the retinal pigment epithelium (RPE)...
  18. doi request reprint Outer retinal hyperreflective spots on spectral-domain optical coherence tomography in macular telangiectasia type 2
    Sönke Baumüller
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Ophthalmology 117:2162-8. 2010
    ..To analyze focal hyperreflective morphologic alterations in outer retinal layers in patients with type 2 idiopathic macular telangiectasia (MacTel type 2) using spectral-domain optical coherence tomography (SD OCT)...
  19. doi request reprint The impact of the severity of vision loss on vision-specific functioning in a German outpatient population - an observational study
    Robert P Finger
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Graefes Arch Clin Exp Ophthalmol 249:1245-53. 2011
    ..To validate the German-translated VF-14, a vision-specific scale, and determine the relationship between the severity of vision impairment, ocular conditions, and visual functioning...
  20. doi request reprint Tracking progression with spectral-domain optical coherence tomography in geographic atrophy caused by age-related macular degeneration
    Monika Fleckenstein
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 51:3846-52. 2010
    ..To investigate, with the use of spectral-domain optical coherence tomography (SD-OCT), microstructural alterations over time in eyes with progressive geographic atrophy (GA) due to age-related macular degeneration...
  21. doi request reprint In vivo imaging of foveal sparing in geographic atrophy secondary to age-related macular degeneration
    Steffen Schmitz-Valckenberg
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 50:3915-21. 2009
    ..To investigate morphologic alterations in geographic atrophy caused by age-related macular degeneration (AMD) in the presence of foveal sparing using high-resolution in vivo imaging...
  22. ncbi request reprint Correlation between the area of increased autofluorescence surrounding geographic atrophy and disease progression in patients with AMD
    Steffen Schmitz-Valckenberg
    Department of Ophthalmology, University of Bonn, Bonn, Germany, and First Eye Hospital, University of Lublin, Poland
    Invest Ophthalmol Vis Sci 47:2648-54. 2006
    ....
  23. doi request reprint Intraocular pharmacokinetics of ranibizumab following a single intravitreal injection in humans
    Tim U Krohne
    University of Bonn, Department of Ophthalmology, Germany
    Am J Ophthalmol 154:682-686.e2. 2012
    ..To investigate intraocular concentrations and pharmacokinetics of ranibizumab after a single intravitreal injection in humans...
  24. ncbi request reprint Digital simultaneous fluorescein and indocyanine green angiography, autofluorescence, and red-free imaging with a solid-state laser-based confocal scanning laser ophthalmoscope
    Jork J Jorzik
    Department of Ophthalmology, University of Heidelberg, Germany
    Retina 25:405-16. 2005
    ..To describe and to evaluate a novel confocal scanning laser ophthalmoscope (cSLO) for fluorescence angiography, fundus autofluorescence (FAF), and red-free imaging...
  25. doi request reprint Spectral domain optical coherence tomography in adult-onset vitelliform macular dystrophy with cuticular drusen
    Robert P Finger
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Retina 30:1455-64. 2010
    ....
  26. ncbi request reprint Progression of geographic atrophy and impact of fundus autofluorescence patterns in age-related macular degeneration
    Frank G Holz
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Am J Ophthalmol 143:463-72. 2007
    ..To test if fundus autofluorescence (FAF) patterns around geographic atrophy (GA) have an impact on GA progression rates over time in atrophic age-related macular degeneration (AMD)...
  27. ncbi request reprint Classification of fundus autofluorescence patterns in early age-related macular disease
    Almut Bindewald
    Department of Ophthalmology, University of Bonn, Ernst Abbe Strasse 2, 53127 Bonn, Germany
    Invest Ophthalmol Vis Sci 46:3309-14. 2005
    ..To describe and classify patterns of abnormal fundus autofluorescence (FAF) in eyes with early nonexudative age-related macular disease (AMD)...
  28. doi request reprint Effects of lipid peroxidation products on lipofuscinogenesis and autophagy in human retinal pigment epithelial cells
    Tim U Krohne
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Exp Eye Res 90:465-71. 2010
    ..These mechanisms may contribute to RPE cell dysfunction and degeneration in AMD...
  29. doi request reprint Fundus autofluorescence imaging: review and perspectives
    Steffen Schmitz-Valckenberg
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Retina 28:385-409. 2008
    ..Its clinical value coupled with its simple, efficient, and noninvasive nature is increasingly appreciated. This review summarizes basic principles and FAF findings in various retinal diseases...
  30. doi request reprint Multimodal imaging including spectral domain OCT and confocal near infrared reflectance for characterization of outer retinal pathology in pseudoxanthoma elasticum
    Peter Charbel Issa
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 50:5913-8. 2009
    ....
  31. doi request reprint Quantification of reduced macular pigment optical density in the central retina in macular telangiectasia type 2
    Peter Charbel Issa
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Exp Eye Res 89:25-31. 2009
    ..This disease might serve as a model to further study abnormalities of MP distribution in retinal disorders and to elucidate the mechanisms of MP deposition in the retina...
  32. ncbi request reprint Accumulation of A2-E in mitochondrial membranes of cultured RPE cells
    Florian Schutt
    Department of Ophthalmology, University of Heidelberg, INF 400, 69120, Heidelberg, Germany
    Graefes Arch Clin Exp Ophthalmol 245:391-8. 2007
    ..This would require release or leakage of A2-E from the lysosomal compartment with subsequent targeting of other cellular compartments...
  33. doi request reprint Confocal blue reflectance imaging in type 2 idiopathic macular telangiectasia
    Peter Charbel Issa
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 49:1172-7. 2008
    ..To report the characteristics of confocal blue reflectance imaging in type 2 idiopathic macular telangiectasia (type 2 IMT)...
  34. pmc The relative impact of vision impairment and cardiovascular disease on quality of life: the example of pseudoxanthoma elasticum
    Robert P Finger
    Department of Ophthalmology, University of Bonn, Ernst Abbe Strasse 2, D 53127, Bonn, Germany
    Health Qual Life Outcomes 9:113. 2011
    ..To investigate the impact of pseudoxanthoma elasticum (PXE), a rare hereditary disease of concurrent vision impairment (VI) and cardiovascular complications (CVCs), on vision-related (VRQoL) and health-related quality of life (HRQoL)...
  35. pmc CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD
    Hendrik P N Scholl
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    PLoS ONE 4:e7418. 2009
    ....
  36. pmc Fundus autofluorescence and spectral-domain optical coherence tomography characteristics in a rapidly progressing form of geographic atrophy
    Monika Fleckenstein
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 52:3761-6. 2011
    ..To further characterize a previously described phenotypic variant of geographic atrophy (GA) associated with rapid progression and a diffuse-trickling appearance on fundus autofluorescence (FAF)...
  37. ncbi request reprint Fundus autofluorescence and fundus perimetry in the junctional zone of geographic atrophy in patients with age-related macular degeneration
    Steffen Schmitz-Valckenberg
    Department of Ophthalmology, University of Bonn, Abbe Strasse 2, D 53127 Bonn, Germany
    Invest Ophthalmol Vis Sci 45:4470-6. 2004
    ..To investigate retinal sensitivity in the junctional zone of geographic atrophy (GA), with variations in fundus autofluorescence (FAF) in patients with advanced age-related macular degeneration (AMD)...
  38. doi request reprint Multimodal fundus imaging in foveal hypoplasia: combined scanning laser ophthalmoscope imaging and spectral-domain optical coherence tomography
    Peter Charbel Issa
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Arch Ophthalmol 126:1463-5. 2008
  39. ncbi request reprint Effects of lipid peroxidation-related protein modifications on RPE lysosomal functions and POS phagocytosis
    Elke Kaemmerer
    Department of Pathology, University of Heidelberg, Heidelberg, Germany
    Invest Ophthalmol Vis Sci 48:1342-7. 2007
    ..The present study was conducted to test the hypothesis that these damaged proteins are more resistant to proteolytic attack and act as protease inhibitors...
  40. doi request reprint Fundus autofluorescence and progression of age-related macular degeneration
    Steffen Schmitz-Valckenberg
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Surv Ophthalmol 54:96-117. 2009
    ....
  41. ncbi request reprint Findings in fluorescein angiography and optical coherence tomography after intravitreal bevacizumab in type 2 idiopathic macular telangiectasia
    Peter Charbel Issa
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Ophthalmology 114:1736-42. 2007
    ..To report the short-term effects of intravitreal bevacizumab in patients with type 2 idiopathic macular telangiectasia (IMT)...
  42. doi request reprint Concordance of disease progression in bilateral geographic atrophy due to AMD
    Monika Fleckenstein
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 51:637-42. 2010
    ..To determine the degree of concordance for progression rate, size of atrophy, and visual acuity in patients with bilateral geographic atrophy (GA) due to age-related macular degeneration (AMD)...
  43. doi request reprint Combined treatment of acute subretinal haemorrhages with intravitreal recombined tissue plasminogen activator, expansile gas and bevacizumab: a retrospective pilot study
    Carsten H Meyer
    Department of Ophthalmology, University of Bonn, Germany
    Acta Ophthalmol 86:490-4. 2008
    ..To assess the effectiveness of consecutive intravitreal injections of recombined tissue plasminogen activator (rtPA), expansile gas and bevacizumab in eyes with acute subretinal haemorrhage (SRH)...
  44. doi request reprint Longitudinal analysis of reticular drusen associated with geographic atrophy in age-related macular degeneration
    Julia S Steinberg
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 54:4054-60. 2013
    ..To characterize longitudinal changes of reticular drusen (RDR) in subjects with geographic atrophy (GA) secondary to age-related macular degeneration in the multicenter, prospective natural history Geographic Atrophy Progression Study...
  45. doi request reprint Regular provision of outreach increases acceptance of cataract surgery in South India
    Robert P Finger
    Department of Ophthalmology, University of Bonn, Germany
    Trop Med Int Health 16:1268-75. 2011
    ....
  46. doi request reprint Safety and efficacy of a flexible dosing regimen of ranibizumab in neovascular age-related macular degeneration: the SUSTAIN study
    Frank G Holz
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Ophthalmology 118:663-71. 2011
    ..To evaluate the safety and efficacy of individualized ranibizumab treatment in patients with neovascular age-related macular degeneration...
  47. ncbi request reprint Microperimetric assessment of patients with type 2 idiopathic macular telangiectasia
    Peter Charbel Issa
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 48:3788-95. 2007
    ..To assess changes of the light increment sensitivity (LIS) of the macular area in patients with type 2 idiopathic macular telangiectasia (IMT)...
  48. ncbi request reprint Confocal scanning laser ophthalmoscopy findings in chronic solar retinopathy
    Peter Charbel Issa
    Department of Ophthalmology, University of Bonn, Ernst Abbe Strasse 2, 53127 Bonn, Germany
    Ophthalmic Surg Lasers Imaging 39:497-9. 2008
    ..The authors recommend including noninvasive confocal scanning laser ophthalmoscopy imaging in the work-up of unexplained visual disturbances because it may add important information beyond ophthalmoscopy and other imaging techniques...
  49. doi request reprint The effects of a flexible visual acuity-driven ranibizumab treatment regimen in age-related macular degeneration: outcomes of a drug and disease model
    Frank G Holz
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 51:405-12. 2010
    ..In the present study, a drug and disease model was used to evaluate the impact of an individualized, flexible treatment regimen on disease progression...
  50. doi request reprint Intraocular pharmacokinetics of bevacizumab after a single intravitreal injection in humans
    Tim U Krohne
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Am J Ophthalmol 146:508-12. 2008
    ..To investigate intraocular concentrations and pharmacokinetics of bevacizumab after a single intravitreal injection in humans...
  51. doi request reprint Evaluation of autofluorescence imaging with the scanning laser ophthalmoscope and the fundus camera in age-related geographic atrophy
    Steffen Schmitz-Valckenberg
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Am J Ophthalmol 146:183-92. 2008
    ..To compare fundus autofluorescence images (FAF) between a modified fundus camera (mFC) and a confocal scanning laser ophthalmoscope (cSLO)...
  52. doi request reprint Macular hole formation in the presence of a pigment epithelial detachment after three consecutive intravitreal antivascular endothelial growth factor injections
    Christoph R Clemens
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    J Ocul Pharmacol Ther 26:297-9. 2010
    ....
  53. doi request reprint Monthly ranibizumab for choroidal neovascularizations secondary to angioid streaks in pseudoxanthoma elasticum: a one-year prospective study
    Robert P Finger
    Department of Ophthalmology, University of Bonn, Germany
    Am J Ophthalmol 152:695-703. 2011
    ..To evaluate the efficacy and safety of monthly intravitreal ranibizumab for the treatment of choroidal neovascularizations (CNV) secondary to angioid streaks (AS) in pseudoxanthoma elasticum (PXE)...
  54. pmc The impact of successful cataract surgery on quality of life, household income and social status in South India
    Robert P Finger
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    PLoS ONE 7:e44268. 2012
    ..To explore the hypothesis that sight restoring cataract surgery provided to impoverished rural communities will improve not only visual acuity and vision-related quality of life (VRQoL) but also poverty and social status...
  55. ncbi request reprint Topography of geographic atrophy in age-related macular degeneration
    Matthias M Mauschitz
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 53:4932-9. 2012
    ..To determine the topographic distribution and progression of geographic atrophy (GA) in patients with AMD...
  56. ncbi request reprint Agreement among ophthalmologists in evaluating fluorescein angiograms in patients with neovascular age-related macular degeneration for photodynamic therapy eligibility (FLAP-study)
    Frank G Holz
    Department of Ophthalmology, University of Heidelberg, Im Neuenheimer Feld 400, D 69120 Heidelberg, Germany
    Ophthalmology 110:400-5. 2003
    ..To determine intraobserver and interobserver variation for classifying types of choroidal neovascularizations (CNV) in exudative age-related macular degeneration (ARMD)...
  57. doi request reprint In vivo visualization of dendritic cells, macrophages, and microglial cells responding to laser-induced damage in the fundus of the eye
    Nicole Eter
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 49:3649-58. 2008
    ..e., dendritic cells [DCs] and macrophages [MPhis]) in the posterior eye segment after laser-induced injury, and to gain a better understanding of the role of these cells in inflammatory eye disease...
  58. doi request reprint Reticular drusen associated with geographic atrophy in age-related macular degeneration
    Steffen Schmitz-Valckenberg
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 52:5009-15. 2011
    ..To characterize reticular drusen (RDR) in patients with geographic atrophy (GA) secondary to age-related macular degeneration (AMD) in a prospective, multicenter, natural history study...
  59. doi request reprint Lipid peroxidation products reduce lysosomal protease activities in human retinal pigment epithelial cells via two different mechanisms of action
    Tim U Krohne
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Exp Eye Res 90:261-6. 2010
    ..Via these mechanisms, lipid peroxidation products may induce lysosomal dysfunction and lipofuscinogenesis in the aging RPE and thus contribute to the pathogenesis of AMD...
  60. doi request reprint Visual functioning and quality of life under low luminance: evaluation of the German Low Luminance Questionnaire
    Robert P Finger
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 52:8241-9. 2011
    ....
  61. doi request reprint Monthly ranibizumab for nonproliferative macular telangiectasia type 2: a 12-month prospective study
    Peter Charbel Issa
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Am J Ophthalmol 151:876-886.e1. 2011
    ..To investigate the efficacy and safety of intravitreal ranibizumab for the treatment of nonproliferative macular telangiectasia (MacTel) type 2...
  62. ncbi request reprint Changes in fundus autofluorescence in patients with age-related maculopathy. Correlation to visual function: a prospective study
    Wilma Einbock
    Department of Ophthalmology, University of Leipzig, Liebigstrasse 10 14, 04103, Leipzig, Germany
    Graefes Arch Clin Exp Ophthalmol 243:300-5. 2005
    ..As members of the Fundus Autofluorescence in Age-related Macular Degeneration Study Group (FAM Study Group), we report changes of fundus autofluorescence (AF) in patients with multiple soft drusen in correlation to visual function...
  63. ncbi request reprint Symmetry of bilateral lesions in geographic atrophy in patients with age-related macular degeneration
    Caren Bellmann
    Department of Ophthalmology, University of Heidelberg, Im Neuenheimer Feld 400, D 69120 Heidelberg, Germany
    Arch Ophthalmol 120:579-84. 2002
    ..To assess symmetry, we determined intraindividual variations of various features of bilateral geographic atrophy in patients with atrophic age-related macular degeneration in a cross-sectional study...
  64. doi request reprint Discrete arcs of increased fundus autofluorescence in retinal dystrophies and functional correlate on microperimetry
    M Fleckenstein
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Eye (Lond) 23:567-75. 2009
    ..To describe the occurrence of discrete arcs of increased fundus autofluorescence (FAF) associated with various retinal dystrophies and to assess their functional significance by fundus-controlled microperimetry...
  65. doi request reprint Subretinal delivery of ultrathin rigid-elastic cell carriers using a metallic shooter instrument and biodegradable hydrogel encapsulation
    Boris V Stanzel
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 53:490-500. 2012
    ..To develop a surgical technique for the subretinal implantation of cell carriers suitable for the transplantation of cultured retinal pigment epithelium (RPE) in a preclinical animal model...
  66. doi request reprint Intraocular pharmacokinetics after a single intravitreal injection of 1.5 mg versus 3.0 mg of bevacizumab in humans
    Carsten H Meyer
    Department of Ophthalmology, University of Bonn, Germany
    Retina 31:1877-84. 2011
    ..To compare the concentration of unbound bevacizumab in the anterior chamber of patients with macular edema, who received a single intravitreal injection of two different dosages...
  67. doi request reprint Apical-to-basolateral transcytosis of photoreceptor outer segments induced by lipid peroxidation products in human retinal pigment epithelial cells
    Tim U Krohne
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 51:553-60. 2010
    ..Herein, they tested RPE cells for the basolateral release of undegraded modified POS proteins...
  68. ncbi request reprint Analysis of digital scanning laser ophthalmoscopy fundus autofluorescence images of geographic atrophy in advanced age-related macular degeneration
    Steffen Schmitz-Valckenberg
    Department of Ophthalmology, University of Heidelberg, Germany
    Graefes Arch Clin Exp Ophthalmol 240:73-8. 2002
    ..We have evaluated a method for automated computerized detection and quantitation of RPE atrophy...
  69. doi request reprint Concentrations of unbound bevacizumab in the aqueous of untreated fellow eyes after a single intravitreal injection in humans
    Carsten H Meyer
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Acta Ophthalmol 90:68-70. 2012
    ..To determine the concentration of unbound bevacizumab in untreated fellow eyes after contralateral intravitreal injection of bevacizumab...
  70. doi request reprint Localisation and significance of in vivo near-infrared autofluorescent signal in retinal imaging
    Steffen Schmitz-Valckenberg
    Department of Ophthalmology, Ernst Abbe Str 2, 53127 Bonn, Germany
    Br J Ophthalmol 95:1134-9. 2011
    ....
  71. doi request reprint Prevalence and causes of registered blindness in the largest federal state of Germany
    Robert P Finger
    Department of Ophthalmology, University of Bonn, Ernst Abbe Str 2, 53127 Bonn, Germany
    Br J Ophthalmol 95:1061-7. 2011
    ..5 million people in the federal state of Northrhine) assessing eligibility for an allowance payable to blind people was used to investigate the prevalence and the specific causes of blindness and visual impairment...
  72. ncbi request reprint Age-related structural abnormalities in the human retina-choroid complex revealed by two-photon excited autofluorescence imaging
    Meng Han
    University of Heidelberg, Mannheim Biomedical Engineering Laboratories, Faculty of Clinical Medicine, Heidelberg, Germany
    J Biomed Opt 12:024012. 2007
    ....
  73. ncbi request reprint Visual acuity and contrast sensitivity in patients with neovascular age-related macular degeneration. Results from the Radiation Therapy for Age-Related Macular Degeneration (RAD-) Study
    Caren Bellmann
    Department of Ophthalmology, University of Heidelberg, INF 400, 69120 Heidelberg, Germany
    Graefes Arch Clin Exp Ophthalmol 241:968-74. 2003
    ..We examined VA and CS changes over time in patients with subfoveal choroidal neovascularizations (CNV) as well as the correlation between the two parameters...
  74. ncbi request reprint Isolation of intact lysosomes from human RPE cells and effects of A2-E on the integrity of the lysosomal and other cellular membranes
    Florian Schutt
    Department of Ophthamology, University of Heidelberg, Germany
    Graefes Arch Clin Exp Ophthalmol 240:983-8. 2002
    ..Lipofuscin and its major retinoid compound and fluorophore A2-E interfere with the cellular metabolism of RPE cells in various ways. One of these mechanisms is thought to be related to detergent properties of A2-E...
  75. pmc Classification of abnormal fundus autofluorescence patterns in the junctional zone of geographic atrophy in patients with age related macular degeneration
    A Bindewald
    Department of Ophthalmology, University of Bonn, Ernst Abbe Strasse 2, D 53127 Bonn, Germany
    Br J Ophthalmol 89:874-8. 2005
    ..To describe and classify patterns of abnormal fundus autofluorescence (FAF) in the junctional zone of geographic atrophy (GA) in patients with age related macular degeneration...
  76. doi request reprint Eighteen-month follow-up of intravitreal bevacizumab in type 2 idiopathic macular telangiectasia
    P Charbel Issa
    Department of Ophthalmology, University of Bonn, Ernst Abbe Str 2, D 53127 Bonn, Germany
    Br J Ophthalmol 92:941-5. 2008
    ..To evaluate the effects of intravitreal bevacizumab for non-proliferative type 2 idiopathic macular telangiectasia (type 2 IMT) within a mean follow-up period of 18 months...
  77. ncbi request reprint Inhibition of the ATP-driven proton pump in RPE lysosomes by the major lipofuscin fluorophore A2-E may contribute to the pathogenesis of age-related macular degeneration
    M Bergmann
    Department of Molecular Pathology, University of Heidelberg, Heidelberg, Germany
    FASEB J 18:562-4. 2004
    ..These data support the hypothesis that A2-E-induced lysosomal dysfunction contributes to the pathogenesis of AMD and other retinal diseases associated with excessive lipofuscin accumulation...
  78. ncbi request reprint Proteins modified by malondialdehyde, 4-hydroxynonenal, or advanced glycation end products in lipofuscin of human retinal pigment epithelium
    Florian Schutt
    Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany
    Invest Ophthalmol Vis Sci 44:3663-8. 2003
    ..Toxic LF compounds may interfere with normal RPE function. Oxidative modification of proteins was determined in LF granules from human eyes...
  79. ncbi request reprint [Diagnostic vitrectomy in uveitis: possibilities of molecular biology]
    M D Becker
    Interdiszplinäres Uveitiszentrum Heidelberg, Heidelberg
    Ophthalmologe 100:796-801. 2003
    ..Genetic markers as well as species-specific sequences are used for the diagnostics of infection or masquerade syndromes. This article provides state-of-the art information about diagnostic vitrectomy...
  80. ncbi request reprint Proteome analysis of lipofuscin in human retinal pigment epithelial cells
    F Schutt
    Department of Ophthalmology, INF 400, D 69120 Heidelberg, Germany
    FEBS Lett 528:217-21. 2002
    ..Besides a better understanding of downstream pathways, this approach may provide new targets for therapeutic interventions in a currently untreatable disease...
  81. ncbi request reprint [Detergent-like effects of the lipofuscin retinoid component A2-E in retinal pigment epithelial cells]
    F Schutt
    Abteilung für Pathochemie und Allgemeine Neurochemie des Pathologischen Institutes, Heidelberg, Germany
    Ophthalmologe 99:861-5. 2002
    ..Here we sought to evaluate additional toxic mechanisms of A2-E, whereby possible detergent-like effects on various membranes in human RPE cells were investigated by latency measurements...
  82. ncbi request reprint Modelling the natural history of geographic atrophy in patients with age-related macular degeneration
    J Dreyhaupt
    Department of Medical Biometry and Informatics, University of Heidelberg, Germany
    Ophthalmic Epidemiol 12:353-62. 2005
    ..To model the natural course of geographic atrophy (GA) in patients with age-related macular degeneration (AMD)...
  83. pmc Digital analysis of choroidal neovascularisation in consecutive fluorescein angiograms for use in longitudinal clinical trials
    C Bellmann
    Department of Ophthalmology, University of Heidelberg, Germany
    Br J Ophthalmol 87:890-2. 2003
    ..The development and evaluation of an image analysis software for this purpose is described here. It allows for the quantitative analysis of changes in CNV and/or leakage area over time...
  84. ncbi request reprint [Retinal vein occlusions]
    S Dithmar
    Universitäts Augenklinik Heidelberg
    Ophthalmologe 100:561-77; quiz 578. 2003
    ..This overview provides information on the current knowledge of the pathogenesis and both established approaches and those in ongoing clinical trials for the treatment of central venous and branch vein occlusions...
  85. pmc Automated analysis of digital fundus autofluorescence images of geographic atrophy in advanced age-related macular degeneration using confocal scanning laser ophthalmoscopy (cSLO)
    A Deckert
    Institute of Medical Biometry and Informatics, University of Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany
    BMC Ophthalmol 5:8. 2005
    ..Automated computer-assisted methods for detecting and removing interfering vessels are needed to support the GA quantification process in longitudinal studies and in reading centres...
  86. ncbi request reprint Lipids and lipid peroxidation products in the pathogenesis of age-related macular degeneration
    J Kopitz
    Institute of Molecular Pathology, University of Heidelberg, Im Neuenheimer Feld 220, 69120 Heidelberg, Germany
    Biochimie 86:825-31. 2004
    ..The possible mechanisms underlying this lysosomal dysfunction and the resulting adverse effects on overall RPE function are discussed...
  87. ncbi request reprint [Therapeutic vitrectomy in uveitis: current status and recommendations]
    M D Becker
    Interdiszplinäres Uveitiszentrum Heidelberg, Heidelberg
    Ophthalmologe 100:787-95. 2003
    ..Here, the current knowledge on the subject is reviewed and critically discussed, and recommendations for patient management are given. Further studies are needed...
  88. ncbi request reprint Discovery of factors influencing the growth of geographic atrophy in patients with age-related macular degeneration
    J Dreyhaupt
    Institute of Medical Biometry and Informatics, University of Heidelberg, INF 305, 69120 Heidelberg, Germany
    Methods Inf Med 46:432-9. 2007
    ..Identifying factors influencing the growth of geographic atrophy (GA) in patients with age-related macular degeneration (AMD)...
  89. ncbi request reprint Bull's eye maculopathy in cat-eye syndrome
    H Steffen
    Department of Ophthalmology, University of Heidelberg, Germany
    Retina 22:223-5. 2002
  90. ncbi request reprint [A retinoid constituent of lipofuscin, A2-E, is a photosensitizer in human retinal pigment epithelial cells]
    F Schutt
    Universitäts Augenklinik Heidelberg
    Ophthalmologe 97:682-7. 2000
    ..This study addressed the phototoxic potential of A2-E on RPE cells...
  91. ncbi request reprint Simultaneous confocal scanning laser fluorescein and indocyanine green angiography
    F G Holz
    Department of Ophthalmology, University of Heidelberg, Germany
    Am J Ophthalmol 125:227-36. 1998
    ..To evaluate clinically a recently developed confocal scanning laser ophthalmoscope for simultaneous fluorescein and indocyanine green angiography...
  92. ncbi request reprint Patterns of increased in vivo fundus autofluorescence in the junctional zone of geographic atrophy of the retinal pigment epithelium associated with age-related macular degeneration
    F G Holz
    Department of Ophthalmology, University of Heidelberg, Germany
    Graefes Arch Clin Exp Ophthalmol 237:145-52. 1999
    ..To determine in vivo lipofuscin (LF)-induced topographic variations of fundus autofluorescence in eyes with geographic atrophy (GA) of the retinal pigment epithelium (RPE) associated with age-related macular degeneration (ARMD)...
  93. ncbi request reprint [The molecular mechanisms of neovascular age-related macular degeneration]
    D W Miller
    Universitäts Augenklinik Heidelberg
    Ophthalmologe 100:92-6. 2003
    ..This article describes current research in the pathophysiology of choroidal neovascularization secondary to age-related macular degeneration...
  94. pmc Lower limits of fluorescein and indocyanine green dye for digital cSLO fluorescence angiography
    A Bindewald
    Department of Ophthalmology, University of Bonn, Ernst Abbe Strasse 2, D 53127 Bonn, Germany
    Br J Ophthalmol 89:1609-15. 2005
    ..Here we used a novel confocal scanning laser ophthalmoscope (cSLO) to determine lower limits of dye required for fluorescein (FL) and indocyanine green (ICG) angiography...
  95. ncbi request reprint Multifocal ERG recording with simultaneous fundus monitoring using a confocal scanning laser ophthalmoscope
    C M Poloschek
    Department of Ophthamology, University of Heidelberg, Germany
    Eye (Lond) 17:159-66. 2003
    ..To assess the general feasibility of recording multifocal electroretinograms (mfERGs) with simultaneous fundus monitoring in a clinical setting...
  96. doi request reprint Intravitreal bevacizumab for choroidal neovascularisation associated with pseudoxanthoma elasticum
    R P Finger
    Department of Ophthalmology, University of Bonn, Ernst Abbe Str 2, 53127 Bonn, Germany
    Br J Ophthalmol 92:483-7. 2008
    ..To investigate the efficacy of intravitreal bevacizumab injections for treating choroidal neovascularisation (CNV) secondary to pseudoxanthoma elasticum (PXE)...
  97. ncbi request reprint [Incidence and extent of postoperative macular edema following vitreoretinal surgery with and without combined cataract operation]
    S Staudt
    Universitats Augenklinik, Heidelberg, Germany
    Ophthalmologe 100:702-7. 2003
    ..We evaluated the incidence and extent of macular edema after macular foramen surgery with and without combined cataract-surgery...
  98. doi request reprint Effect of 308 nm excimer laser irradiation on retinal pigment epithelium cell viability in vitro
    T U Krohne
    Department of Ophthalmology, University of Bonn, Ernst Abbe Str 2, D 53127 Bonn, Germany
    Br J Ophthalmol 93:91-5. 2009
    ..This study assessed potential adverse effects of excimer irradiation on RPE cells in vitro...
  99. ncbi request reprint Two-photon-excited fluorescence imaging of human RPE cells with a femtosecond Ti:Sapphire laser
    Almut Bindewald-Wittich
    Department of Ophthalmology, University of Bonn, Germany
    Invest Ophthalmol Vis Sci 47:4553-7. 2006
    ..To record the distribution and spectrum of human retinal pigment epithelial cell lipofuscin (LF) by two-photon-excited fluorescence (TPEF) and confocal laser scanning microscopy...
  100. ncbi request reprint Indocyanine green angiography in the presence of subretinal or intraretinal haemorrhages: clinical and experimental investigations
    Florian Schutt
    Department of Ophthalmology, Institute of Applied Physics and Institute of Pathology, Universityof Heidelberg, Heidelberg, Germany
    Clin Experiment Ophthalmol 30:110-4. 2002
    ..The degree and frequency of blockage by haemorrhages during ICG-A and fluorescein angiography (Fl-A) were compared and absorption characteristics by blood were experimentally determined...
  101. doi request reprint Macular full-thickness and lamellar holes in association with type 2 idiopathic macular telangiectasia
    P Charbel Issa
    Department of Ophthalmology, University of Bonn, Germany
    Eye (Lond) 23:435-41. 2009
    ..To describe patients with full-thickness macular holes (FTMHs) and lamellar macular holes (LMHs) in association with type 2 idiopathic macular telangiectasia (type 2 IMT)...