Frank G Holz

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi Intraocular microablation of choroidal tissue by a 308 nm AIDA excimer laser for RPE-transplantation in patients with age-related macular degeneration
    F G Holz
    Universitäts Augenklinik Heidelberg Im Neuenheimer Feld 400 D 69120 Heidelberg
    Biomed Tech (Berl) 48:82-5. 2003
  2. ncbi [Pharmacological therapy for age-related macular degeneration. Current developments and perspectives]
    F G Holz
    Universitäts Augenklinik Heidelberg
    Ophthalmologe 100:97-103. 2003
  3. ncbi Visualization of retinal pigment epithelial cells in vivo using digital high-resolution confocal scanning laser ophthalmoscopy
    Almut Bindewald
    Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany
    Am J Ophthalmol 137:556-8. 2004
  4. ncbi Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration
    F G Holz
    Department of Ophthalmology, University of Heidelberg, Germany
    Invest Ophthalmol Vis Sci 42:1051-6. 2001
  5. ncbi [Autofluorescence imaging of the macula]
    F G Holz
    Augenklinik der Ruprecht Karls Universität Heidelberg
    Ophthalmologe 98:10-8. 2001
  6. ncbi Combined intravitreal bevacizumab and photodynamic therapy for neovascular age-related macular degeneration
    Markus S Ladewig
    Department of Ophthalmology, University of Bonn, Ernst Abbe Strasse 2, 53127, Bonn, Germany
    Graefes Arch Clin Exp Ophthalmol 246:17-25. 2008
  7. ncbi Fundus autofluorescence in Pseudoxanthoma elasticum
    Robert P Finger
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Retina 29:1496-505. 2009
  8. ncbi Reading performance is reduced by parafoveal scotomas in patients with macular telangiectasia type 2
    Robert P Finger
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 50:1366-70. 2009
  9. ncbi Correlation of macular function with retinal thickness in nonproliferative type 2 idiopathic macular telangiectasia
    Peter Charbel Issa
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Am J Ophthalmol 145:169-175. 2008
  10. ncbi Clinical evaluation of simultaneous confocal scanning laser ophthalmoscopy imaging combined with high-resolution, spectral-domain optical coherence tomography
    Hans Martin Helb
    Department of Ophthalmology, University of Bonn, Germany
    Acta Ophthalmol 88:842-9. 2010

Detail Information

Publications122 found, 100 shown here

  1. ncbi Intraocular microablation of choroidal tissue by a 308 nm AIDA excimer laser for RPE-transplantation in patients with age-related macular degeneration
    F G Holz
    Universitäts Augenklinik Heidelberg Im Neuenheimer Feld 400 D 69120 Heidelberg
    Biomed Tech (Berl) 48:82-5. 2003
    ..In preclinical experiments we used a 308 nm UV AIDA excimer laser to microablate choroidal tissue from such a graft in human donor eyes...
  2. ncbi [Pharmacological therapy for age-related macular degeneration. Current developments and perspectives]
    F G Holz
    Universitäts Augenklinik Heidelberg
    Ophthalmologe 100:97-103. 2003
    ..Other targets include the inhibition of toxic compound formation in lipofuscin granules such as AZ-E. What follows is an overview of different substances and their stages of development in clinical trials...
  3. ncbi Visualization of retinal pigment epithelial cells in vivo using digital high-resolution confocal scanning laser ophthalmoscopy
    Almut Bindewald
    Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany
    Am J Ophthalmol 137:556-8. 2004
    ..To visualize retinal pigment epithelial cells in vivo by fundus autofluorescence imaging using a confocal scanning laser ophthalmoscope...
  4. ncbi Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration
    F G Holz
    Department of Ophthalmology, University of Heidelberg, Germany
    Invest Ophthalmol Vis Sci 42:1051-6. 2001
    ....
  5. ncbi [Autofluorescence imaging of the macula]
    F G Holz
    Augenklinik der Ruprecht Karls Universität Heidelberg
    Ophthalmologe 98:10-8. 2001
    ..Furthermore, identification of high-risk characteristics in patients with age-related macular degeneration with this technique may be helpful for indicating and adjusting future therapies...
  6. ncbi Combined intravitreal bevacizumab and photodynamic therapy for neovascular age-related macular degeneration
    Markus S Ladewig
    Department of Ophthalmology, University of Bonn, Ernst Abbe Strasse 2, 53127, Bonn, Germany
    Graefes Arch Clin Exp Ophthalmol 246:17-25. 2008
    ..Our aim was to evaluate the short-term safety and efficacy of combined photodynamic therapy (PDT) with verteporfin and intravitreal bevacizumab in neovascular age-related macular degeneration (AMD)...
  7. ncbi Fundus autofluorescence in Pseudoxanthoma elasticum
    Robert P Finger
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Retina 29:1496-505. 2009
    ..Changes in Bruch membrane lead to progressive atrophy of the retinal pigment epithelium (RPE), secondary CNVs, and visual loss. The RPE-photoreceptor complex was studied in vivo using fundus autofluorescence (FAF) imaging...
  8. ncbi Reading performance is reduced by parafoveal scotomas in patients with macular telangiectasia type 2
    Robert P Finger
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 50:1366-70. 2009
    ..In an investigation of their significance for reading performance, reading acuity and speed were measured and correlated with parafoveal sensitivity and fixation stability...
  9. ncbi Correlation of macular function with retinal thickness in nonproliferative type 2 idiopathic macular telangiectasia
    Peter Charbel Issa
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Am J Ophthalmol 145:169-175. 2008
    ..To correlate macular thickness determined by optical coherence tomography (OCT) with light increment sensitivity and visual acuity in patients with type 2 idiopathic macular telangiectasia (IMT)...
  10. ncbi Clinical evaluation of simultaneous confocal scanning laser ophthalmoscopy imaging combined with high-resolution, spectral-domain optical coherence tomography
    Hans Martin Helb
    Department of Ophthalmology, University of Bonn, Germany
    Acta Ophthalmol 88:842-9. 2010
    ....
  11. ncbi Long-term effectiveness of intravitreal bevacizumab for choroidal neovascularization secondary to angioid streaks in pseudoxanthoma elasticum
    Robert P Finger
    Department of Ophthalmology, University of Bonn, Germany
    Retina 31:1268-78. 2011
    ..To investigate the long-term effectiveness of intravitreal bevacizumab for treating active choroidal neovascularizations in pseudoxanthoma elasticum (PXE)...
  12. ncbi The impact of the severity of vision loss on vision-related quality of life in India: an evaluation of the IND-VFQ-33
    Robert P Finger
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 52:6081-8. 2011
    ..To validate the 33-item Indian Vision Functioning Questionnaire (IND-VFQ-33), a vision-specific scale, and determine the relationship between the severity of vision impairment (VI) and vision-related quality of life (VRQoL)...
  13. ncbi Metamorphopsia in patients with macular telangiectasia type 2
    Peter Charbel Issa
    Department of Ophthalmology, University of Bonn, Ernst Abbe Str 2, 53127, Bonn, Germany
    Doc Ophthalmol 119:133-40. 2009
    ..To assess metamorphopsia in patients with macular telangiectasia (MacTel) type 2...
  14. ncbi Abnormal macular pigment distribution in type 2 idiopathic macular telangiectasia
    Hans Martin Helb
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Retina 28:808-16. 2008
    ..To determine the distribution of macular pigment in type 2 idiopathic macular telangiectasia (IMT)...
  15. ncbi High-resolution spectral domain-OCT imaging in geographic atrophy associated with age-related macular degeneration
    Monika Fleckenstein
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 49:4137-44. 2008
    ..To describe morphologic variations in outer retinal layers in eyes with atrophic age-related macular degeneration (AMD) using high-resolution, spectral-domain optical coherence tomography (SD-OCT)...
  16. ncbi Correlation of lines of increased autofluorescence in macular dystrophy and pigmented paravenous retinochoroidal atrophy by optical coherence tomography
    Monika Fleckenstein
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Arch Ophthalmol 126:1461-3. 2008
  17. ncbi High-resolution optical coherence tomography of subpigment epithelial structures in patients with pigment epithelium detachment secondary to age-related macular degeneration
    Christoph R Clemens
    Department of Ophthalmology, University of Muenster, Muenster, Germany
    Br J Ophthalmol 96:1088-91. 2012
    ..Spectral domain optical coherence tomography (SD-OCT) allows for improved morphological characterisation of the space underneath the retinal pigment epithelium (RPE)...
  18. ncbi The impact of the severity of vision loss on vision-specific functioning in a German outpatient population - an observational study
    Robert P Finger
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Graefes Arch Clin Exp Ophthalmol 249:1245-53. 2011
    ..To validate the German-translated VF-14, a vision-specific scale, and determine the relationship between the severity of vision impairment, ocular conditions, and visual functioning...
  19. ncbi In vivo imaging of foveal sparing in geographic atrophy secondary to age-related macular degeneration
    Steffen Schmitz-Valckenberg
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 50:3915-21. 2009
    ..To investigate morphologic alterations in geographic atrophy caused by age-related macular degeneration (AMD) in the presence of foveal sparing using high-resolution in vivo imaging...
  20. ncbi Outer retinal hyperreflective spots on spectral-domain optical coherence tomography in macular telangiectasia type 2
    Sönke Baumüller
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Ophthalmology 117:2162-8. 2010
    ..To analyze focal hyperreflective morphologic alterations in outer retinal layers in patients with type 2 idiopathic macular telangiectasia (MacTel type 2) using spectral-domain optical coherence tomography (SD OCT)...
  21. ncbi Tracking progression with spectral-domain optical coherence tomography in geographic atrophy caused by age-related macular degeneration
    Monika Fleckenstein
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 51:3846-52. 2010
    ..To investigate, with the use of spectral-domain optical coherence tomography (SD-OCT), microstructural alterations over time in eyes with progressive geographic atrophy (GA) due to age-related macular degeneration...
  22. ncbi Intraocular pharmacokinetics of ranibizumab following a single intravitreal injection in humans
    Tim U Krohne
    University of Bonn, Department of Ophthalmology, Germany
    Am J Ophthalmol 154:682-686.e2. 2012
    ..To investigate intraocular concentrations and pharmacokinetics of ranibizumab after a single intravitreal injection in humans...
  23. ncbi Effects of lipid peroxidation products on lipofuscinogenesis and autophagy in human retinal pigment epithelial cells
    Tim U Krohne
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Exp Eye Res 90:465-71. 2010
    ..These mechanisms may contribute to RPE cell dysfunction and degeneration in AMD...
  24. ncbi Spectral domain optical coherence tomography in adult-onset vitelliform macular dystrophy with cuticular drusen
    Robert P Finger
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Retina 30:1455-64. 2010
    ....
  25. ncbi Progression of geographic atrophy and impact of fundus autofluorescence patterns in age-related macular degeneration
    Frank G Holz
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Am J Ophthalmol 143:463-72. 2007
    ..To test if fundus autofluorescence (FAF) patterns around geographic atrophy (GA) have an impact on GA progression rates over time in atrophic age-related macular degeneration (AMD)...
  26. ncbi Accumulation of A2-E in mitochondrial membranes of cultured RPE cells
    Florian Schutt
    Department of Ophthalmology, University of Heidelberg, INF 400, 69120, Heidelberg, Germany
    Graefes Arch Clin Exp Ophthalmol 245:391-8. 2007
    ..This would require release or leakage of A2-E from the lysosomal compartment with subsequent targeting of other cellular compartments...
  27. ncbi Digital simultaneous fluorescein and indocyanine green angiography, autofluorescence, and red-free imaging with a solid-state laser-based confocal scanning laser ophthalmoscope
    Jork J Jorzik
    Department of Ophthalmology, University of Heidelberg, Germany
    Retina 25:405-16. 2005
    ..A solid-state laser has advantages compared to argon gas laser sources, including less space occupation, heat emission, and noise production...
  28. ncbi Quantification of reduced macular pigment optical density in the central retina in macular telangiectasia type 2
    Peter Charbel Issa
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Exp Eye Res 89:25-31. 2009
    ..This disease might serve as a model to further study abnormalities of MP distribution in retinal disorders and to elucidate the mechanisms of MP deposition in the retina...
  29. ncbi Fundus autofluorescence imaging: review and perspectives
    Steffen Schmitz-Valckenberg
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Retina 28:385-409. 2008
    ..Its clinical value coupled with its simple, efficient, and noninvasive nature is increasingly appreciated. This review summarizes basic principles and FAF findings in various retinal diseases...
  30. ncbi Multimodal imaging including spectral domain OCT and confocal near infrared reflectance for characterization of outer retinal pathology in pseudoxanthoma elasticum
    Peter Charbel Issa
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 50:5913-8. 2009
    ....
  31. ncbi Confocal blue reflectance imaging in type 2 idiopathic macular telangiectasia
    Peter Charbel Issa
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 49:1172-7. 2008
    ..To report the characteristics of confocal blue reflectance imaging in type 2 idiopathic macular telangiectasia (type 2 IMT)...
  32. ncbi Classification of fundus autofluorescence patterns in early age-related macular disease
    Almut Bindewald
    Department of Ophthalmology, University of Bonn, Ernst-Abbe-Strasse 2, 53127 Bonn, Germany
    Invest Ophthalmol Vis Sci 46:3309-14. 2005
    ....
  33. ncbi The relative impact of vision impairment and cardiovascular disease on quality of life: the example of pseudoxanthoma elasticum
    Robert P Finger
    Department of Ophthalmology, University of Bonn, Ernst Abbe Strasse 2, D 53127, Bonn, Germany
    Health Qual Life Outcomes 9:113. 2011
    ..To investigate the impact of pseudoxanthoma elasticum (PXE), a rare hereditary disease of concurrent vision impairment (VI) and cardiovascular complications (CVCs), on vision-related (VRQoL) and health-related quality of life (HRQoL)...
  34. ncbi Concordance of disease progression in bilateral geographic atrophy due to AMD
    Monika Fleckenstein
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 51:637-42. 2010
    ..To determine the degree of concordance for progression rate, size of atrophy, and visual acuity in patients with bilateral geographic atrophy (GA) due to age-related macular degeneration (AMD)...
  35. ncbi CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD
    Hendrik P N Scholl
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    PLoS ONE 4:e7418. 2009
    ....
  36. ncbi Findings in fluorescein angiography and optical coherence tomography after intravitreal bevacizumab in type 2 idiopathic macular telangiectasia
    Peter Charbel Issa
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Ophthalmology 114:1736-42. 2007
    ..To report the short-term effects of intravitreal bevacizumab in patients with type 2 idiopathic macular telangiectasia (IMT)...
  37. ncbi Correlation between the area of increased autofluorescence surrounding geographic atrophy and disease progression in patients with AMD
    Steffen Schmitz-Valckenberg
    Department of Ophthalmology, University of Bonn, Bonn, Germany, and First Eye Hospital, University of Lublin, Poland
    Invest Ophthalmol Vis Sci 47:2648-54. 2006
    ..As the FAF signal originates from lipofuscin (LF) in postmitotic RPE cells and since increased FAF indicates excessive LF accumulation, these findings would underscore the pathophysiological role of RPE-LF in AMD pathogenesis...
  38. ncbi Effects of lipid peroxidation-related protein modifications on RPE lysosomal functions and POS phagocytosis
    Elke Kaemmerer
    Department of Pathology, University of Heidelberg, Heidelberg, Germany
    Invest Ophthalmol Vis Sci 48:1342-7. 2007
    ..The present study was conducted to test the hypothesis that these damaged proteins are more resistant to proteolytic attack and act as protease inhibitors...
  39. ncbi Multimodal fundus imaging in foveal hypoplasia: combined scanning laser ophthalmoscope imaging and spectral-domain optical coherence tomography
    Peter Charbel Issa
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Arch Ophthalmol 126:1463-5. 2008
  40. ncbi Combined treatment of acute subretinal haemorrhages with intravitreal recombined tissue plasminogen activator, expansile gas and bevacizumab: a retrospective pilot study
    Carsten H Meyer
    Department of Ophthalmology, University of Bonn, Germany
    Acta Ophthalmol 86:490-4. 2008
    ..To assess the effectiveness of consecutive intravitreal injections of recombined tissue plasminogen activator (rtPA), expansile gas and bevacizumab in eyes with acute subretinal haemorrhage (SRH)...
  41. ncbi Fundus autofluorescence and fundus perimetry in the junctional zone of geographic atrophy in patients with age-related macular degeneration
    Steffen Schmitz-Valckenberg
    Department of Ophthalmology, University of Bonn, Abbe Strasse 2, D 53127 Bonn, Germany
    Invest Ophthalmol Vis Sci 45:4470-6. 2004
    ..To investigate retinal sensitivity in the junctional zone of geographic atrophy (GA), with variations in fundus autofluorescence (FAF) in patients with advanced age-related macular degeneration (AMD)...
  42. ncbi Fundus autofluorescence and spectral-domain optical coherence tomography characteristics in a rapidly progressing form of geographic atrophy
    Monika Fleckenstein
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 52:3761-6. 2011
    ..To further characterize a previously described phenotypic variant of geographic atrophy (GA) associated with rapid progression and a diffuse-trickling appearance on fundus autofluorescence (FAF)...
  43. ncbi Fundus autofluorescence and progression of age-related macular degeneration
    Steffen Schmitz-Valckenberg
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Surv Ophthalmol 54:96-117. 2009
    ....
  44. ncbi Regular provision of outreach increases acceptance of cataract surgery in South India
    Robert P Finger
    Department of Ophthalmology, University of Bonn, Germany
    Trop Med Int Health 16:1268-75. 2011
    ....
  45. ncbi Confocal scanning laser ophthalmoscopy findings in chronic solar retinopathy
    Peter Charbel Issa
    Department of Ophthalmology, University of Bonn, Ernst Abbe Strasse 2, 53127 Bonn, Germany
    Ophthalmic Surg Lasers Imaging 39:497-9. 2008
    ..The authors recommend including noninvasive confocal scanning laser ophthalmoscopy imaging in the work-up of unexplained visual disturbances because it may add important information beyond ophthalmoscopy and other imaging techniques...
  46. ncbi Evaluation of autofluorescence imaging with the scanning laser ophthalmoscope and the fundus camera in age-related geographic atrophy
    Steffen Schmitz-Valckenberg
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Am J Ophthalmol 146:183-92. 2008
    ..To compare fundus autofluorescence images (FAF) between a modified fundus camera (mFC) and a confocal scanning laser ophthalmoscope (cSLO)...
  47. ncbi Intraocular pharmacokinetics of bevacizumab after a single intravitreal injection in humans
    Tim U Krohne
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Am J Ophthalmol 146:508-12. 2008
    ..To investigate intraocular concentrations and pharmacokinetics of bevacizumab after a single intravitreal injection in humans...
  48. ncbi Microperimetric assessment of patients with type 2 idiopathic macular telangiectasia
    Peter Charbel Issa
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 48:3788-95. 2007
    ..To assess changes of the light increment sensitivity (LIS) of the macular area in patients with type 2 idiopathic macular telangiectasia (IMT)...
  49. ncbi Safety and efficacy of a flexible dosing regimen of ranibizumab in neovascular age-related macular degeneration: the SUSTAIN study
    Frank G Holz
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Ophthalmology 118:663-71. 2011
    ..To evaluate the safety and efficacy of individualized ranibizumab treatment in patients with neovascular age-related macular degeneration...
  50. ncbi Monthly ranibizumab for choroidal neovascularizations secondary to angioid streaks in pseudoxanthoma elasticum: a one-year prospective study
    Robert P Finger
    Department of Ophthalmology, University of Bonn, Germany
    Am J Ophthalmol 152:695-703. 2011
    ..To evaluate the efficacy and safety of monthly intravitreal ranibizumab for the treatment of choroidal neovascularizations (CNV) secondary to angioid streaks (AS) in pseudoxanthoma elasticum (PXE)...
  51. ncbi Macular hole formation in the presence of a pigment epithelial detachment after three consecutive intravitreal antivascular endothelial growth factor injections
    Christoph R Clemens
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    J Ocul Pharmacol Ther 26:297-9. 2010
    ....
  52. ncbi The effects of a flexible visual acuity-driven ranibizumab treatment regimen in age-related macular degeneration: outcomes of a drug and disease model
    Frank G Holz
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 51:405-12. 2010
    ..In the present study, a drug and disease model was used to evaluate the impact of an individualized, flexible treatment regimen on disease progression...
  53. ncbi The impact of successful cataract surgery on quality of life, household income and social status in South India
    Robert P Finger
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    PLoS ONE 7:e44268. 2012
    ..To explore the hypothesis that sight restoring cataract surgery provided to impoverished rural communities will improve not only visual acuity and vision-related quality of life (VRQoL) but also poverty and social status...
  54. ncbi Topography of geographic atrophy in age-related macular degeneration
    Matthias M Mauschitz
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 53:4932-9. 2012
    ..To determine the topographic distribution and progression of geographic atrophy (GA) in patients with AMD...
  55. ncbi Agreement among ophthalmologists in evaluating fluorescein angiograms in patients with neovascular age-related macular degeneration for photodynamic therapy eligibility (FLAP-study)
    Frank G Holz
    Department of Ophthalmology, University of Heidelberg, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany
    Ophthalmology 110:400-5. 2003
    ..Because various current and emerging treatments including photodynamic therapy are based on specific angiographic characteristics, accurate interpretation will become more important...
  56. ncbi Symmetry of bilateral lesions in geographic atrophy in patients with age-related macular degeneration
    Caren Bellmann
    Department of Ophthalmology, University of Heidelberg, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany
    Arch Ophthalmol 120:579-84. 2002
    ..Symmetric manifestations, rather, reflect specific individual determinants in the pathogenesis and manifestation of the disease...
  57. ncbi In vivo visualization of dendritic cells, macrophages, and microglial cells responding to laser-induced damage in the fundus of the eye
    Nicole Eter
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 49:3649-58. 2008
    ..e., dendritic cells [DCs] and macrophages [MPhis]) in the posterior eye segment after laser-induced injury, and to gain a better understanding of the role of these cells in inflammatory eye disease...
  58. ncbi Visual functioning and quality of life under low luminance: evaluation of the German Low Luminance Questionnaire
    Robert P Finger
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 52:8241-9. 2011
    ....
  59. ncbi Lipid peroxidation products reduce lysosomal protease activities in human retinal pigment epithelial cells via two different mechanisms of action
    Tim U Krohne
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Exp Eye Res 90:261-6. 2010
    ..Via these mechanisms, lipid peroxidation products may induce lysosomal dysfunction and lipofuscinogenesis in the aging RPE and thus contribute to the pathogenesis of AMD...
  60. ncbi Reticular drusen associated with geographic atrophy in age-related macular degeneration
    Steffen Schmitz-Valckenberg
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 52:5009-15. 2011
    ..To characterize reticular drusen (RDR) in patients with geographic atrophy (GA) secondary to age-related macular degeneration (AMD) in a prospective, multicenter, natural history study...
  61. ncbi Monthly ranibizumab for nonproliferative macular telangiectasia type 2: a 12-month prospective study
    Peter Charbel Issa
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Am J Ophthalmol 151:876-886.e1. 2011
    ..To investigate the efficacy and safety of intravitreal ranibizumab for the treatment of nonproliferative macular telangiectasia (MacTel) type 2...
  62. ncbi Changes in fundus autofluorescence in patients with age-related maculopathy. Correlation to visual function: a prospective study
    Wilma Einbock
    Department of Ophthalmology, University of Leipzig, Liebigstrasse 10-14, 04103, Leipzig, Germany
    Graefes Arch Clin Exp Ophthalmol 243:300-5. 2005
    ..Our preliminary data suggest that a patchy pattern of AF indicates a relatively high risk of progression to age-related macular degeneration with visual loss...
  63. ncbi Discrete arcs of increased fundus autofluorescence in retinal dystrophies and functional correlate on microperimetry
    M Fleckenstein
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Eye (Lond) 23:567-75. 2009
    ..To describe the occurrence of discrete arcs of increased fundus autofluorescence (FAF) associated with various retinal dystrophies and to assess their functional significance by fundus-controlled microperimetry...
  64. ncbi Subretinal delivery of ultrathin rigid-elastic cell carriers using a metallic shooter instrument and biodegradable hydrogel encapsulation
    Boris V Stanzel
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 53:490-500. 2012
    ..To develop a surgical technique for the subretinal implantation of cell carriers suitable for the transplantation of cultured retinal pigment epithelium (RPE) in a preclinical animal model...
  65. ncbi Intraocular pharmacokinetics after a single intravitreal injection of 1.5 mg versus 3.0 mg of bevacizumab in humans
    Carsten H Meyer
    Department of Ophthalmology, University of Bonn, Germany
    Retina 31:1877-84. 2011
    ..To compare the concentration of unbound bevacizumab in the anterior chamber of patients with macular edema, who received a single intravitreal injection of two different dosages...
  66. ncbi Analysis of digital scanning laser ophthalmoscopy fundus autofluorescence images of geographic atrophy in advanced age-related macular degeneration
    Steffen Schmitz-Valckenberg
    Department of Ophthalmology, University of Heidelberg, Germany
    Graefes Arch Clin Exp Ophthalmol 240:73-8. 2002
    ....
  67. ncbi Apical-to-basolateral transcytosis of photoreceptor outer segments induced by lipid peroxidation products in human retinal pigment epithelial cells
    Tim U Krohne
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Invest Ophthalmol Vis Sci 51:553-60. 2010
    ..Herein, they tested RPE cells for the basolateral release of undegraded modified POS proteins...
  68. ncbi Concentrations of unbound bevacizumab in the aqueous of untreated fellow eyes after a single intravitreal injection in humans
    Carsten H Meyer
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Acta Ophthalmol 90:68-70. 2012
    ..To determine the concentration of unbound bevacizumab in untreated fellow eyes after contralateral intravitreal injection of bevacizumab...
  69. ncbi Visual acuity and contrast sensitivity in patients with neovascular age-related macular degeneration. Results from the Radiation Therapy for Age-Related Macular Degeneration (RAD-) Study
    Caren Bellmann
    Department of Ophthalmology, University of Heidelberg, INF 400, 69120 Heidelberg, Germany
    Graefes Arch Clin Exp Ophthalmol 241:968-74. 2003
    ..Both parameters provide important information about visual disability and should be evaluated as outcome in interventional studies...
  70. ncbi Age-related structural abnormalities in the human retina-choroid complex revealed by two-photon excited autofluorescence imaging
    Meng Han
    University of Heidelberg, Mannheim Biomedical Engineering Laboratories, Faculty of Clinical Medicine, Heidelberg, Germany
    J Biomed Opt 12:024012. 2007
    ....
  71. ncbi Localisation and significance of in vivo near-infrared autofluorescent signal in retinal imaging
    Steffen Schmitz-Valckenberg
    Department of Ophthalmology, Ernst Abbe Str 2, 53127 Bonn, Germany
    Br J Ophthalmol 95:1134-9. 2011
    ....
  72. ncbi Prevalence and causes of registered blindness in the largest federal state of Germany
    Robert P Finger
    Department of Ophthalmology, University of Bonn, Ernst Abbe Str 2, 53127 Bonn, Germany
    Br J Ophthalmol 95:1061-7. 2011
    ..5 million people in the federal state of Northrhine) assessing eligibility for an allowance payable to blind people was used to investigate the prevalence and the specific causes of blindness and visual impairment...
  73. ncbi Isolation of intact lysosomes from human RPE cells and effects of A2-E on the integrity of the lysosomal and other cellular membranes
    Florian Schutt
    Department of Ophthamology, University of Heidelberg, Germany
    Graefes Arch Clin Exp Ophthalmol 240:983-8. 2002
    ..Lipofuscin and its major retinoid compound and fluorophore A2-E interfere with the cellular metabolism of RPE cells in various ways. One of these mechanisms is thought to be related to detergent properties of A2-E...
  74. ncbi Classification of abnormal fundus autofluorescence patterns in the junctional zone of geographic atrophy in patients with age related macular degeneration
    A Bindewald
    Department of Ophthalmology, University of Bonn, Ernst-Abbe-Strasse 2, D-53127 Bonn, Germany
    Br J Ophthalmol 89:874-8. 2005
    ..A refined phenotypic classification may be helpful to identify prognostic determinants for the spread of atrophy and visual loss, for identification of genetic risk factors as well as for the design of future interventional trials...
  75. ncbi Eighteen-month follow-up of intravitreal bevacizumab in type 2 idiopathic macular telangiectasia
    P Charbel Issa
    Department of Ophthalmology, University of Bonn, Ernst Abbe Str 2, D 53127 Bonn, Germany
    Br J Ophthalmol 92:941-5. 2008
    ..To evaluate the effects of intravitreal bevacizumab for non-proliferative type 2 idiopathic macular telangiectasia (type 2 IMT) within a mean follow-up period of 18 months...
  76. ncbi Inhibition of the ATP-driven proton pump in RPE lysosomes by the major lipofuscin fluorophore A2-E may contribute to the pathogenesis of age-related macular degeneration
    M Bergmann
    Department of Molecular Pathology, University of Heidelberg, Heidelberg, Germany
    FASEB J 18:562-4. 2004
    ..These data support the hypothesis that A2-E-induced lysosomal dysfunction contributes to the pathogenesis of AMD and other retinal diseases associated with excessive lipofuscin accumulation...
  77. ncbi Proteins modified by malondialdehyde, 4-hydroxynonenal, or advanced glycation end products in lipofuscin of human retinal pigment epithelium
    Florian Schutt
    Department of Ophthalmology, University of Heidelberg, Heidelberg, Germany
    Invest Ophthalmol Vis Sci 44:3663-8. 2003
    ..Toxic LF compounds may interfere with normal RPE function. Oxidative modification of proteins was determined in LF granules from human eyes...
  78. ncbi [Diagnostic vitrectomy in uveitis: possibilities of molecular biology]
    M D Becker
    Interdiszplinäres Uveitiszentrum Heidelberg, Heidelberg
    Ophthalmologe 100:796-801. 2003
    ..Genetic markers as well as species-specific sequences are used for the diagnostics of infection or masquerade syndromes. This article provides state-of-the art information about diagnostic vitrectomy...
  79. ncbi Proteome analysis of lipofuscin in human retinal pigment epithelial cells
    F Schutt
    Department of Ophthalmology, INF 400, D 69120 Heidelberg, Germany
    FEBS Lett 528:217-21. 2002
    ..Besides a better understanding of downstream pathways, this approach may provide new targets for therapeutic interventions in a currently untreatable disease...
  80. ncbi [Detergent-like effects of the lipofuscin retinoid component A2-E in retinal pigment epithelial cells]
    F Schutt
    Abteilung für Pathochemie und Allgemeine Neurochemie des Pathologischen Institutes, Heidelberg, Germany
    Ophthalmologe 99:861-5. 2002
    ..Here we sought to evaluate additional toxic mechanisms of A2-E, whereby possible detergent-like effects on various membranes in human RPE cells were investigated by latency measurements...
  81. ncbi Modelling the natural history of geographic atrophy in patients with age-related macular degeneration
    J Dreyhaupt
    Department of Medical Biometry and Informatics, University of Heidelberg, Germany
    Ophthalmic Epidemiol 12:353-62. 2005
    ..To model the natural course of geographic atrophy (GA) in patients with age-related macular degeneration (AMD)...
  82. ncbi Digital analysis of choroidal neovascularisation in consecutive fluorescein angiograms for use in longitudinal clinical trials
    C Bellmann
    Department of Ophthalmology, University of Heidelberg, Germany
    Br J Ophthalmol 87:890-2. 2003
    ..The software is applicable to future clinical trials where the analysis of neovascular complex changes is required, for example, following therapeutic intervention...
  83. ncbi [Retinal vein occlusions]
    S Dithmar
    Universitäts Augenklinik Heidelberg
    Ophthalmologe 100:561-77; quiz 578. 2003
    ..This overview provides information on the current knowledge of the pathogenesis and both established approaches and those in ongoing clinical trials for the treatment of central venous and branch vein occlusions...
  84. ncbi Automated analysis of digital fundus autofluorescence images of geographic atrophy in advanced age-related macular degeneration using confocal scanning laser ophthalmoscopy (cSLO)
    A Deckert
    Institute of Medical Biometry and Informatics, University of Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany
    BMC Ophthalmol 5:8. 2005
    ..Automated computer-assisted methods for detecting and removing interfering vessels are needed to support the GA quantification process in longitudinal studies and in reading centres...
  85. ncbi Lipids and lipid peroxidation products in the pathogenesis of age-related macular degeneration
    J Kopitz
    Institute of Molecular Pathology, University of Heidelberg, Im Neuenheimer Feld 220, 69120 Heidelberg, Germany
    Biochimie 86:825-31. 2004
    ..The possible mechanisms underlying this lysosomal dysfunction and the resulting adverse effects on overall RPE function are discussed...
  86. ncbi [Therapeutic vitrectomy in uveitis: current status and recommendations]
    M D Becker
    Interdiszplinäres Uveitiszentrum Heidelberg, Heidelberg
    Ophthalmologe 100:787-95. 2003
    ..Here, the current knowledge on the subject is reviewed and critically discussed, and recommendations for patient management are given. Further studies are needed...
  87. ncbi Discovery of factors influencing the growth of geographic atrophy in patients with age-related macular degeneration
    J Dreyhaupt
    Institute of Medical Biometry and Informatics, University of Heidelberg, INF 305, 69120 Heidelberg, Germany
    Methods Inf Med 46:432-9. 2007
    ..Identifying factors influencing the growth of geographic atrophy (GA) in patients with age-related macular degeneration (AMD)...
  88. ncbi [The molecular mechanisms of neovascular age-related macular degeneration]
    D W Miller
    Universitäts Augenklinik Heidelberg
    Ophthalmologe 100:92-6. 2003
    ..This article describes current research in the pathophysiology of choroidal neovascularization secondary to age-related macular degeneration...
  89. ncbi Bull's eye maculopathy in cat-eye syndrome
    H Steffen
    Department of Ophthalmology, University of Heidelberg, Germany
    Retina 22:223-5. 2002
  90. ncbi Simultaneous confocal scanning laser fluorescein and indocyanine green angiography
    F G Holz
    Department of Ophthalmology, University of Heidelberg, Germany
    Am J Ophthalmol 125:227-36. 1998
    ..To evaluate clinically a recently developed confocal scanning laser ophthalmoscope for simultaneous fluorescein and indocyanine green angiography...
  91. ncbi [A retinoid constituent of lipofuscin, A2-E, is a photosensitizer in human retinal pigment epithelial cells]
    F Schutt
    Universitäts Augenklinik Heidelberg
    Ophthalmologe 97:682-7. 2000
    ..This study addressed the phototoxic potential of A2-E on RPE cells...
  92. ncbi Patterns of increased in vivo fundus autofluorescence in the junctional zone of geographic atrophy of the retinal pigment epithelium associated with age-related macular degeneration
    F G Holz
    Department of Ophthalmology, University of Heidelberg, Germany
    Graefes Arch Clin Exp Ophthalmol 237:145-52. 1999
    ..To determine in vivo lipofuscin (LF)-induced topographic variations of fundus autofluorescence in eyes with geographic atrophy (GA) of the retinal pigment epithelium (RPE) associated with age-related macular degeneration (ARMD)...
  93. ncbi Multifocal ERG recording with simultaneous fundus monitoring using a confocal scanning laser ophthalmoscope
    C M Poloschek
    Department of Ophthamology, University of Heidelberg, Germany
    Eye 17:159-66. 2003
    ..However, further improvement of the technique appears necessary before considering routine clinical application...
  94. ncbi Lower limits of fluorescein and indocyanine green dye for digital cSLO fluorescence angiography
    A Bindewald
    Department of Ophthalmology, University of Bonn, Ernst-Abbe-Strasse 2, D-53127 Bonn, Germany
    Br J Ophthalmol 89:1609-15. 2005
    ..These amounts can be used for routine angiography and allow relevant savings for units performing FL-A...
  95. ncbi Effect of 308 nm excimer laser irradiation on retinal pigment epithelium cell viability in vitro
    T U Krohne
    Department of Ophthalmology, University of Bonn, Ernst Abbe Str 2, D 53127 Bonn, Germany
    Br J Ophthalmol 93:91-5. 2009
    ..This study assessed potential adverse effects of excimer irradiation on RPE cells in vitro...
  96. ncbi [Incidence and extent of postoperative macular edema following vitreoretinal surgery with and without combined cataract operation]
    S Staudt
    , Heidelberg, Germany
    Ophthalmologe 100:702-7. 2003
    ..Furthermore it seems that a combined cataract operation compared to a consecutive procedure is not associated with disadvantages regarding the functional outcome...
  97. ncbi Intravitreal bevacizumab for choroidal neovascularisation associated with pseudoxanthoma elasticum
    R P Finger
    Department of Ophthalmology, University of Bonn, Ernst Abbe Str 2, 53127 Bonn, Germany
    Br J Ophthalmol 92:483-7. 2008
    ..To investigate the efficacy of intravitreal bevacizumab injections for treating choroidal neovascularisation (CNV) secondary to pseudoxanthoma elasticum (PXE)...
  98. ncbi Two-photon-excited fluorescence imaging of human RPE cells with a femtosecond Ti:Sapphire laser
    Almut Bindewald-Wittich
    Department of Ophthalmology, University of Bonn, Germany
    Invest Ophthalmol Vis Sci 47:4553-7. 2006
    ..With the proof of principle from this ex vivo study, further work is now planned to evaluate the safety of TPEF RPE imaging in RPE cultures and animal models...
  99. ncbi Indocyanine green angiography in the presence of subretinal or intraretinal haemorrhages: clinical and experimental investigations
    Florian Schutt
    Department of Ophthalmology, Institute of Applied Physics and Institute of Pathology, Universityof Heidelberg, Heidelberg, Germany
    Clin Experiment Ophthalmol 30:110-4. 2002
    ..The degree and frequency of blockage by haemorrhages during ICG-A and fluorescein angiography (Fl-A) were compared and absorption characteristics by blood were experimentally determined...
  100. ncbi Macular full-thickness and lamellar holes in association with type 2 idiopathic macular telangiectasia
    P Charbel Issa
    Department of Ophthalmology, University of Bonn, Germany
    Eye (Lond) 23:435-41. 2009
    ..To describe patients with full-thickness macular holes (FTMHs) and lamellar macular holes (LMHs) in association with type 2 idiopathic macular telangiectasia (type 2 IMT)...
  101. ncbi Kjellin's syndrome: fundus autofluorescence, angiographic, and electrophysiologic findings
    Inez B Frisch
    Department of Ophthalmology, University of Heidelberg, Germany
    Ophthalmology 109:1484-91. 2002
    ..The abnormal gene product in Kjellin's syndrome seems to cause progressive dysfunction in various neuronal tissues but seems to be distinct from the major defect underlying the Stargardt's disease phenotype...