Research Topics
| Gerald HoltmannSummaryAffiliation: University of Essen Country: Germany Publications
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Publications
[Significance of esophagocardiac reflexes for inducing thoracic pain]G Holtmann
Abteilung für Gastroenterologie und Hepatologie, Universitatsklinikum Essen
Herz 24:154-7. 1999..The available data convincingly demonstrate a reduction of the exertional angina threshold and changes of the ECG (ST segment depression and arrhythmia). These effects are most likely due to a reduced coronary blood flow...- Clinical presentation and personality factors are predictors of the response to treatment in patients with functional dyspepsia; a randomized, double-blind placebo-controlled crossover studyGerald Holtmann
Department of Gastroenterology and Hepatology, University of Essen, Essen, Germany
Dig Dis Sci 49:672-9. 2004..1-0.9). Symptom pattern and psychological disturbances are independent predictors of treatment response. Patients with reflux-like symptoms and greater psychological disturbances are more likely to respond to an acid-lowering compound... - IBS: a syndrome or many diseases?Gerald Holtmann
Department of Gastroenterology, Hepatology and General Internal Medicine, Royal Adelaide Hospital, University of Adelaide, North Terrace, South Australia 5000, Adelaide, Australia
Best Pract Res Clin Gastroenterol 18:91-7. 2004..Thus, it is reasonable to anticipate that IBS will be dissected accordingly and our disease concepts will accept the irritable bowel syndrome as the clinical manifestation of a number of different disorders... - G-protein beta 3 subunit 825 CC genotype is associated with unexplained (functional) dyspepsiaGerald Holtmann
Gastroenterology and Hepatology, University of Essen, Germany
Gastroenterology 126:971-9. 2004..We aimed to assess the association of specific G-protein beta 3 subunit genotypes with functional dyspepsia... - Review article: management of peptic ulcer bleeding-the roles of proton pump inhibitors and Helicobacter pylori eradicationG Holtmann
University of Essen, Department of Gastroenterology, Hufelandstr 55, D 45122, Essen, Germany
Aliment Pharmacol Ther 19:66-70. 2004..e. Helicobacter pylori infection, use of aspirin or nonsteroidal anti-inflammatory drugs). Elimination or modification of these risk factors reduces the risk of ulcer recurrence and, hence, of recurrent ulcer bleeding... - Efficacy of artichoke leaf extract in the treatment of patients with functional dyspepsia: a six-week placebo-controlled, double-blind, multicentre trialG Holtmann
Division of Internal Medicine, Department of Gastroenterology, University of Essen, Germany
Aliment Pharmacol Ther 18:1099-105. 2003..This study aimed to assess the efficacy of artichoke leaf extract (ALE) in the treatment of patients with functional dyspepsia (FD)... - Molecular basis of functional gastrointestinal disordersGerald Holtmann
Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Essen, Hufelandstr 55, 45122 Essen, Germany
Best Pract Res Clin Gastroenterol 18:633-40. 2004..Thus, relevant polymorphisms of genes with immunmodulating and/or neuromodulating features (OPRM1, IL-4, IL-4R, TNFalpha) may also play a role in the manifestation of FGIDs... - Do changes in visceral sensory function determine the development of dyspepsia during treatment with aspirin?Gerald Holtmann
Division of Gastroenterology and Hepatology, University of Essen, Essen, Germany
Gastroenterology 123:1451-8. 2002..We hypothesized that the development of dyspeptic symptoms during treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) would be linked to alterations in gastric mechanosensory function and gastric emptying... - A randomized placebo-controlled trial of simethicone and cisapride for the treatment of patients with functional dyspepsiaG Holtmann
Division of Gastroenterology and Hepatology, University of Essen, Germany
Aliment Pharmacol Ther 16:1641-8. 2002..To compare the efficacy of simethicone with placebo and the prokinetic cisapride in patients with functional dyspepsia... 
Differences in gastric mechanosensory function after repeated ramp distensions in non-consulters with dyspepsia and healthy controlsG Holtmann
Division of Gastroenterology and Hepatology, University of Essen, Germany
Gut 47:332-6. 2000..Decreased rectal thresholds following sigmoid mechanical stimulation have been observed in irritable bowel but this mechanism has not been evaluated in functional dyspepsia...- A randomized, double-blind, comparative study of standard-dose rabeprazole and high-dose omeprazole in gastro-oesophageal reflux diseaseG Holtmann
Department of Gastroenterology and Hepatology, University of Essen, Essen, Germany
Aliment Pharmacol Ther 16:479-85. 2002..Rabeprazole has a faster onset of antisecretory action than omeprazole, and it is of interest to determine whether this translates into faster symptom relief in patients with gastro-oesophageal reflux disease... - Gastric Helicobacter pylori infection accelerates healing of reflux esophagitis during treatment with the proton pump inhibitor pantoprazoleG Holtmann
Department of Gastroenterology and Hepatology, University of Essen, Essen, Germany
Gastroenterology 117:11-6. 1999..pylori-infected patients than in patients without H. pylori infection... - Reflux disease: the disorder of the third millenniumG Holtmann
Department of Gastroenterology, University of Essen, Germany
Eur J Gastroenterol Hepatol 13:S5-11. 2001..Treatment of GORD in the future will require effective techniques to control symptoms, maintain remission, and prevent complications in the affected patient... - Randomised double-blind comparison of simethicone with cisapride in functional dyspepsiaG Holtmann
Division of Gastroenterology, University of Essen, Germany
Aliment Pharmacol Ther 13:1459-65. 1999..To compare the efficacy of simethicone with cisapride in patients with functional (non-ulcer) dyspepsia... - Psychological stress and the severity of post-inflammatory visceral hyperalgesiaTobias Liebregts
Royal Adelaide Hospital, Department of Gastroenterology, Hepatology and General Medicine, University of Adelaide, North Terrace, Adelaide, SA 5000, Australia
Eur J Pain 11:216-22. 2007..Stress and inflammation contribute to this altered visceral sensory function. We aimed to elucidate the role of repetitive stress and acute mucosal inflammation, alone and in combination, on sensory function... - Severity of mucosal inflammation as a predictor for alterations of visceral sensory function in a rat modelBirgit Adam
Royal Adelaide Hospital, Department of Gastroenterology, Hepatology and General Medicine, University of Adelaide, Australia
Pain 123:179-86. 2006..Visceral hyperalgesia occurs after a transient colitis. However, even a mild acute but asymptomatic colitis can induce long-lasting visceral hyperalgesia in the presence of additional stimuli... - The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuliStuart M Brierley
Nerve Gut Research Laboratory, Department of Gastroenterology and Hepatology, Hanson Institute, Royal Adelaide Hospital, Adelaide, South Australia, Australia
Gastroenterology 137:2084-2095.e3. 2009..Sensory information from the GI tract is conducted via 5 afferent subtypes along 3 pathways... - A combination of peppermint oil and caraway oil attenuates the post-inflammatory visceral hyperalgesia in a rat modelBirgit Adam
Department of Gastroenterology, Hepatology and General Medicine, University of Adelaide, Royal Adelaide Hospital, Adelaide, South Australia, Australia
Scand J Gastroenterol 41:155-60. 2006..CONCLUSIONS: These data show that combined treatment with peppermint- and caraway oil modulates post-inflammatory visceral hyperalgesia synergistically. The exact mechanisms have to be further investigated... 
Recombinant human erythropoietin counteracts cisplatin-induced visceral hyperalgesiaMin Suk Yoon
Department of Neurology, University of Duisburg Essen, Essen, Germany
Neurosci Bull 26:282-8. 2010..The present study was aimed to investigate the effect of recombinant human erythropoietin (rhEPO) on cisplatin-induced visceral hyperalgesia...- Public speaking stress-induced neuroendocrine responses and circulating immune cell redistribution in irritable bowel syndromeSigrid Elsenbruch
Department of Medical Psychology, University Hospital of Essen Medical School, Essen, Germany
Am J Gastroenterol 101:2300-7. 2006..Future studies should discern the role of psychopathology in psychological and biological stress responses in IBS... - Heartburn in primary care: problems below the surfaceGerald Holtmann
Division of Internal Medicine, Department of Gastroenterology and Hepatology, University of Essen, Essen, Germany
J Gastroenterol 39:1027-34. 2004..This review discusses the symptoms and risk factors associated with GERD, possible links to Helicobacter pylori infection, and effective treatment strategies within a primary care setting... - Selective role for TRPV4 ion channels in visceral sensory pathwaysStuart M Brierley
Discipline of Physiology, School of Molecular and Biomedical Sciences, The University of Adelaide, Adelaide, Australia
Gastroenterology 134:2059-69. 2008..Here, we show that colonic afferents express a specific molecular transducer that underlies their specialized mechanosensory function: the transient receptor potential channel, vanilloid 4 (TRPV4)... - Immune activation in patients with irritable bowel syndromeTobias Liebregts
Department of Gastroenterology and Hepatology, University of Adelaide, Royal Adelaide Hospital, South Australia, Australia
Gastroenterology 132:913-20. 2007..We further aimed to explore whether symptoms and psychiatric comorbidity in IBS are linked to the release of proinflammatory cytokines... - On-demand treatment of acute heartburn with the antacid hydrotalcite compared with famotidine and placebo: randomized double-blind cross-over studyWolfgang Holtmeier
Department of Gastroenterology, Med Klinik I, J W Goethe Universitat, Frankfurt, Australia
J Clin Gastroenterol 41:564-70. 2007..Antacids are widely used in the self-treatment of gastroesophageal reflux-induced complaints, but respective studies are lacking... - [Evidence-based medicine and phytotherapy for functional dyspepsia and irritable bowel syndrome: a systematic analysis of evidence for the herbal preparation Iberogast]Gerald Holtmann
Departament of Gastroenterology, Hepatology and General Medicine, Royal Adelaide Hospital, University of Adelaide, Adelaide, South Australia, Australien
Wien Med Wochenschr 154:528-34. 2004..In this context, same standards apply as for conventional chemically defined medications... - A placebo-controlled trial of itopride in functional dyspepsiaGerald Holtmann
Department of Gastroenterology, Hepatology and General Medicine, Royal Adelaide Hospital and University of Adelaide, Adelaide, SA, Australia
N Engl J Med 354:832-40. 2006..The treatment of patients with functional dyspepsia remains unsatisfactory. We assessed the efficacy of itopride, a dopamine D2 antagonist with anti-acetylcholinesterase [corrected] effects, in patients with functional dyspepsia... - Psychological comorbidity and complexity of gastrointestinal symptoms in clinically diagnosed irritable bowel syndrome patientsAntonina Mikocka-Walus
Discipline of General Practice and School of Psychology, University of Adelaide, Adelaide, South Australia, Australia
J Gastroenterol Hepatol 23:1137-43. 2008.... - Failed therapy and directions for the future in dyspepsiaGerald Holtmann
Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, University of Adelaide, Adelaide, Australia
Dig Dis 26:218-24. 2008..However, a very careful assessment of potential risks and benefits needs to be undertaken on a case-by-case basis. Other evidence-based measures include psychological interventions such as psychotherapy and hypnotherapy... - Guideline adherence and patient satisfaction in the treatment of inflammatory bowel disorders--an evaluation studyClaudia Pieper
Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, Essen, Germany
BMC Health Serv Res 9:17. 2009..Thus the aim of this study was to identify variables that influence quality of treatment and quality of life as well as patient satisfaction... - Onset of relief of symptoms of gastroesophageal reflux disease: post hoc analysis of two previously published studies comparing pantoprazole 20 mg once daily with nizatidine or ranitidine 150 mg twice dailySebastian Haag
Department of Gastroenterology and Hepatology, University Hospital of Essen, Essen, Germany
Clin Ther 32:678-90. 2010..Systematic assessments of the onset of symptom relief in the treatment of gastroesophageal reflux disease (GERD) are lacking... - Functional dyspepsia is associated with a greater symptomatic response to fat but not carbohydrate, increased fasting and postprandial CCK, and diminished PYYAmelia N Pilichiewicz
University of Adelaide Discipline of Medicine, Royal Adelaide Hospital, Adelaide, Australia
Am J Gastroenterol 103:2613-23. 2008.... - Effects of a fixed combination of peppermint oil and caraway oil on symptoms and quality of life in patients suffering from functional dyspepsiaGerald Holtmann
University of Essen, Department of Gastroenterology and Hepatology, Essen, Germany
Phytomedicine 10:56-7. 2003 - Reflux disease and Barrett's esophagusS Haag
Dept. of Gastroenterology and Hepatology, Institute of Internal Medicine, University of Essen, Essen, Germany
Endoscopy 35:112-7. 2003..For this reason, it is justifiable to carry out curative endoscopic resection. Mucosal ablation procedures may also be appropriate, but these still need to be properly investigated in clinical trials... - Colonic transit studies with 99mTc-rhenium sulfide colloid in live rats. A preliminary studyChris Tsopelas
RAH Radiopharmacy, Nuclear Medicine Department, Royal Adelaide Hospital, North Terrace, Adelaide 5000, South Australia
Hell J Nucl Med 11:96-100. 2008..These results suggest this is a reliable technique of measuring regional colonic transit as a measure of colonic motility in normal rats. This methodology might be well suited to screen potential motility effects of drug candidates... - MR colonography in patients with incomplete conventional colonoscopyWaleed Ajaj
Department of Diagnostic and Interventional Radiology, University Hospital Essen, Hufelandstrasse 55, 45122 Essen, Germany
Radiology 234:452-9. 2005..To assess dark-lumen magnetic resonance (MR) colonography for the evaluation of colonic segments in patients in whom conventional colonoscopy could not be completed... - Serotoninergic and non-serotoninergic effects of two tricyclic antidepressants on visceral nociception in a rat modelLars P Bechmann
Department of Gastroenterology, University of Essen, Germany
Scand J Gastroenterol 44:680-6. 2009..The aim of this study was to compare the antinociceptive effects of different TCAs... - Understanding GERD symptoms in the clinical settingGerald Holtmann
Department of Gastroenterology, Hepatology and General Medicine, Royal Adelaide Hospital, Adelaide, Australia
Drugs Today (Barc) 41:13-7. 2005..Proper symptom assessment as a measure of the severity of disease and for the evaluation of treatment response is required, as are symptom assessment tools for practical clinical use... - Guidance on the use of over-the-counter proton pump inhibitors for the treatment of GERDGerald Holtmann
Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, University of Adelaide, Adelaide, SA, Australia
Int J Clin Pharm 33:493-500. 2011..The aim of this paper was to develop a guideline on the over-the-counter management of gastroesophageal reflux disease with proton pump inhibitors (i.e. omeprazole)... - Recurrent symptoms after fundoplication with a negative pH study--recurrent reflux or functional heartburn?Sarah K Thompson
Discipline of Surgery, University of Adelaide, Adelaide, South Australia, Australia
J Gastrointest Surg 13:54-60. 2009..The aim of our study is to determine whether these patients have an associated functional disorder or abnormal cytokine activity and to examine the reproducibility of pH testing... - Management of reflux symptoms with over-the-counter proton pump inhibitors: issues and proposed guidelinesSebastian Haag
Department of Gastroenterology and Hepatology, University Hospital Essen, Essen, Germany
Digestion 80:226-34. 2009..For the purpose of this review, relevant papers, including national and international guidelines were reviewed and recommendations made for appropriate use of OTC proton pump inhibitor (PPI) therapy... - Effects of Iberogast on proximal gastric volume, antropyloroduodenal motility and gastric emptying in healthy menAmelia N Pilichiewicz
University of Adelaide Discipline of Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia
Am J Gastroenterol 102:1276-83. 2007..The effects of Iberogast on the human gastrointestinal tract have not been evaluated... - Do we know what patients want? The doctor-patient communication gap in functional gastrointestinal disordersJoanne Collins
School of Psychology, University of Adelaide, Adelaide, Australia
Clin Gastroenterol Hepatol 7:1252-4, 1254.e1-2. 2009..Ideally, patients and doctors would have a common understanding of the issues involved. We sought to investigate this with matched questionnaires... - Intraoperative cholangioscopy in the management of biliary adenomasGeorgios C Sotiropoulos
Department of General Surgery and Transplantation, University Hospital Essen, Hufelandstrasse 55, D-45122 Essen, Germany
J Surg Oncol 85:91-2. 2004 - Real time high resolution magnetic resonance imaging for the assessment of gastric motility disordersW Ajaj
Department for Diagnostic and Interventional Radiology, University Hospital Essen, Hufelandstrasse 55, D 45122 Essen, Germany
Gut 53:1256-61. 2004..The aim of this study was to evaluate whether patients with increased or decreased gastric motility can be differentiated from healthy volunteers by means of real time magnetic resonance imaging (MRI)... - [Epidemiology and clinical phenomenology of visceral pain]J M Gschossmann
Abteilung für Gastroenterologie und Hepatologie, Universitatsklinikum Essen, Germany
Schmerz 16:447-51. 2002..Functional gastrointestinal disturbances which are localized in the lower abdomen are summarized as irritable bowel syndrome. Interestingly,both functional dyspepsia and irritable bowel syndrome may overlap... - [Diagnostic criteria and therapeutic strategies of abdominal pain syndromes]J M Gschossmann
Abteilung für Gastroenterologie und Hepatologie, Universitatsklinikum Essen, Germany
Schmerz 16:476-80. 2002..For these disorders no cure is currently available and treatment is targeted towards relief of symptoms only... - Symptom patterns in functional dyspepsia and irritable bowel syndrome: relationship to disturbances in gastric emptying and response to a nutrient challenge in consulters and non-consultersS Haag
Department of Gastroenterology, Hepatology, and General Internal Medicine, Royal Adelaide Hospital, University of Adelaide, North Terrace, Adelaide, South Australia 5000, Australia
Gut 53:1445-51. 2004..CONCLUSION: Gastric emptying and the global symptom response to a standardised nutrient challenge are abnormal in population based (non-health care seeking) subjects with dyspepsia... - An integrated model of care for inflammatory bowel disease sufferers in Australia: development and the effects of its implementationAntonina A Mikocka-Walus
School of Nursing and Midwifery and Sansom Institute for Health Research, University of South Australia, Adelaide, Australia
Inflamm Bowel Dis 18:1573-81. 2012..This review describes the development of such a model and the effects of its implementation in a hospital-based cohort of patients with IBD... - Effect of transient chemically induced colitis on the visceromotor response to mechanical colorectal distensionJürgen M Gschossmann
Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Essen, Hufelandstrasse 55, 45122 Essen, Germany
Eur J Gastroenterol Hepatol 14:1067-72. 2002..Acute mucosal inflammation may initiate alterations of visceral sensory function. However, experimental studies on the potential effects of a transient inflammation on visceral sensitivity are lacking... - H. pylori and functional dyspepsia: increased serum antibodies as an independent risk factor?G Holtmann
Department of Gastroenterology, University of Essen, Germany
Dig Dis Sci 46:1550-7. 2001..6, 95% CI 0.8-2.9) were not associated with frequent dyspepsia. In conclusion, in a subgroup of H. pylori-infected subjects who have high antibody titers, H. pylori appears to be associated with functional dyspepsia... - Epidemiological trends of functional gastrointestinal disordersJ M Gschossmann
Department of Gastroenterology and Hepatology, University of Essen, Hufelandstrasse 55, D-45122 Essen, Germany. Germany
Dig Dis 19:189-94. 2001..Thus, the available data do not provide evidence that the prevalence of these disorders has changed in recent decades... - Serum ferritin and survival of renal transplant recipients: a prospective 10-year cohort studyStefan Herget-Rosenthal
Division of Gastroenterology and Hepatology, Medizinische Klinik, , Hufelandstrasse 52, 45122, Essen, Germany
Transpl Int 16:642-7. 2003..1, confidence interval (CI): 1.1-9.2; P=0.03). These data suggest that serum ferritin levels above 1100 ng/ml due to multiple blood transfusions causing iron overload is a relevant factor that increases mortality... - Validation of the gastrointestinal symptom score for the assessment of symptoms in patients with functional dyspepsiaB Adam
Department of Gastroenterology, Hepatology and General Internal Medicine, Royal Adelaide Hospital, University of Adelaide, Australia
Aliment Pharmacol Ther 22:357-63. 2005..0055). CONCLUSION: The gastrointestinal symptom score is a valid and reliable instrument to assess symptom intensities in patients with functional dyspepsia... - Is there a benefit from intensified medical and psychological interventions in patients with functional dyspepsia not responding to conventional therapy?S Haag
Department of Gastroenterology and Hepatology, and Clinic for Psychosomatic Medicine and Psychotherapy, University Hospital Essen, Essen, Germany
Aliment Pharmacol Ther 25:973-86. 2007..standard medical therapy in patients with refractory functional dyspepsia (FD), referred to a tertiary referral medical center... - Impairment of health-related quality of life in functional dyspepsia and chronic liver disease: the influence of depression and anxietyS Haag
Department of Gastroenterology and Hepatology, University of Essen, Essen, Germany
Aliment Pharmacol Ther 27:561-71. 2008..Data on the relative impairment of HRQOL in chronic liver disease (CLD) and functional gastrointestinal disorders are lacking and no studies have assessed the link between impairment of HRQOL and psychosocial factors yet... - Is there any association between disturbed gastrointestinal visceromotor and sensory function and impaired quality of life in functional dyspepsia?S Haag
Department of Gastroenterology and Hepatology, University of Essen, Essen, Germany
Neurogastroenterol Motil 22:262-e79. 2010..CONCLUSIONS & INFERENCES In EPS and PDS, delayed gastric empting and altered sensory function are disease markers but not directly linked to the severity of HRQOL impairment or clinical presentation of FD... - [Functional gastrointestinal disorders]B Adam
University of Adelaide, Royal Adelaide Hospital, Department of Gastroenterology, Hepatology and General Medicine, North Terrace, Adelaide, SA 5000, Australia
Dtsch Med Wochenschr 131:2531-40, quiz 2541-4. 2006 - International validation of a health-related quality of life questionnaire in patients with erosive gastro-oesophageal reflux diseaseG Holtmann
Department of Medicine, University of Adelaide, Adelaide, SA, Australia
Aliment Pharmacol Ther 29:615-25. 2009.... - Real-time high-resolution MRI for the assessment of gastric motility: pre- and postpharmacological stimuliWaleed Ajaj
Department of Diagnostic and Interventional Radiology, University Hospital Essen, Essen, Germany
J Magn Reson Imaging 19:453-8. 2004..To determine the practicality of MRI using a new real-time sequence for the assessment of gastric motion, and quantify the effects of motility-modifying substances... - Are there alterations of neuroendocrine and cellular immune responses to nutrients in women with irritable bowel syndrome?Sigrid Elsenbruch
Department of Medical Psychology, University Clinic of Essen, Essen, Germany
Am J Gastroenterol 99:703-10. 2004..The goal was to investigate the neuroimmune axis in irritable bowel syndrome (IBS) by analyzing the neuroendocrine and cellular immune responses to nutrient load... - Neuroendocrine and blood pressure responses to rectal distensions in individuals with high and low visceral pain sensitivityS Elsenbruch
Department of Medical Psychology, University Hospital of Essen Medical School, University of Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
Psychoneuroendocrinology 32:580-5. 2007..The mechanisms of interindividual variations in visceral pain sensitivity remain poorly understood. We characterized the neuroendocrine responses to rectal distensions in healthy individuals with high vs. low rectal pain sensitivity... - [Maintaining remission of ulcerative colitis with the probiotic Escherichia Coli Nissle 1917 is as effective as with standard mesalazine]B Adam
Department of Gastroenterology, Hepatology and General Medicine, Royal Adelaide Hospital, University of Adelaide, Australien
Z Gastroenterol 44:267-9. 2006 - [Functional dyspepsia - diagnosis of desperation?]T Liebregts
Department of Gastroenterology, Hepatology and General Medicine, Royal Adelaide Hospital, University of Adelaide, North Terrace, Adelaide, Australia
Internist (Berl) 47:568, 570-2, 574, passim. 2006..While there is currently no therapy that cures functional dyspepsia, the therapeutic target is to control symptoms... - Persistently altered visceral perception after resection of an esophageal granular cell myoblastoma: a therapeutic concept revisitedA Canbay
Department of Medicine, Division of Gastroenterology and Hepatology, Essen University Clinic, Germany
Z Gastroenterol 41:917-20. 2003..Consequently, this case also cautions the therapeutic concept to solely relieve GCT symptoms by resection if the tumor is less than 20 mm in diameter... - Prevalence of unexplained upper abdominal symptoms in patients with migraineT Kurth
Department of Neurology, University Duisburg Essen, Essen, Germany, and Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
Cephalalgia 26:506-10. 2006..Upper abdominal symptoms are significantly more frequent in patients with migraine compared with healthy controls. The association between migraine and idiopathic upper abdominal symptoms may suggest common pathophysiological mechanisms... - Review article: the patient with gastro-oesophageal reflux disease--lifestyle advice and medicationG Holtmann
Department of Gastroenterology, Hepatology and General Medicine, Royal Adelaide Hospital, University of Adelaide, South Australia 5000, Australia
Aliment Pharmacol Ther 20:24-7. 2004..Thus, medication is usually necessary for symptom control. Proton pump inhibitors are now mainstream treatment for the reduction of acid secretion in patients with severe manifestations and 4-week healing rates are approaching 90%... - [Functional dyspepsia]S Haag
, Medizinische Klinik und Poliklinik, , Essen
MMW Fortschr Med 146:51-2. 2004 - [Irritable bowel syndrome]B Adam
Royal Adelaide Hospital, Department of Gastroenterology, Hepatology and General Medicine, University of Adelaide
Dtsch Med Wochenschr 130:399-401. 2005..At present no cure for patients with IBS exists. Thus, all currently available treatments target palliation of symptoms. This, however, may change in the future... - Susceptibility genes and functional gastrointestinal disordersT Liebregts
Department of Gastroenterology, Hepatology and General Medicine, University of Adelaide, Royal Adelaide Hospital, Adelaide, South Australia, Australia
J Gastroenterol Hepatol 20:1792-3. 2005 - Effect of E. coli Nissle 1917 on post-inflammatory visceral sensory function in a rat modelT Liebregts
Department of Gastroenterology, Hepatology and General Medicine, University of Adelaide, Royal Adelaide Hospital, South Australia, Adelaide, Australia
Neurogastroenterol Motil 17:410-4. 2005..CONCLUSION: The EcN administration caused a significant reduction of VH. Whether EcN might play a role in the treatment of post-infectious functional bowel disorders remains to be investigated in further studies... - Papillomatosis confined to the distal biliary tract--a rare cause of obstructive jaundice: report of a caseGeorgios C Sotiropoulos
Department of General Surgery and Transplantation, University Hospital Essen, Hufelandstrasse 55, D-45122 Essen, Germany
Surg Today 33:781-4. 2003..When considering a radical resection, intraoperative cholangioscopy is strongly recommended to confirm any localized papillomatosis and rule out any diffuse papillomatosis of the entire biliary tract... - GERD evaluation: time for a new paradigm?Irvin M Modlin
Yale University School of Medicine, New Haven, CT 06520, USA
J Clin Gastroenterol 41:237-41. 2007..We propose that accurate symptom delineation complemented with endoscopy performed in selected groups of patients will become the mainstay in diagnosis of GERD and the assessment of therapy efficacy... - GERD 2003 -- a consensus on the way aheadSteven F Moss
Brown University, Providence, R.I, USA
Digestion 67:111-7. 2003..Intestinal metaplasia in the lower esophagus is probably very common. Whether and how to, first, screen for, and then, perform surveillance in Barrett's esophagus remains highly problematic and contentious... - Hypothesis driven research and molecular mechanisms in functional dyspepsia: the beginning of a beautiful friendship in research and practice?Gerald Holtmann
Am J Gastroenterol 101:593-5. 2006.... - Increased visceral sensitivity to capsaicin after DSS-induced colitis in mice: spinal cord c-Fos expression and behaviorNiels Eijkelkamp
Laboratory for Psychoneuroimmunology, Univ Medical Center Utrecht, Rm KC 03 063 0, Lundlaan 6, 3584 EA Utrecht, The Netherlands
Am J Physiol Gastrointest Liver Physiol 293:G749-57. 2007.... - Time-resolved three-dimensional MR imaging of gastric emptying modified by IV administration of erythromycinThomas C Lauenstein
Department of Diagnostic Radiology, University Hospital Essen, Hufelandstrasse 55, D-45122 Essen, Germany
AJR Am J Roentgenol 180:1305-10. 2003..In patients with reduced rates of gastric emptying, 3D MR imaging may be an appropriate tool with which to monitor therapeutic approaches, such as the use of prokinetic agents like erythromycin... - Determinants of health-related quality of life in patients with chronic liver diseasesWinfried Häuser
Department of Internal Medicine I, Klinikum Saarbrücken gGmbH, Winterberg 1, D 66119, Saarbruecken, Germany
Clin Gastroenterol Hepatol 2:157-63. 2004.... - Asia-Pacific consensus on the management of gastroesophageal reflux disease: updateKwong Ming Fock
Division of Gastroenterology, Department of Medicine, Changi General Hospital, Singapore
J Gastroenterol Hepatol 23:8-22. 2008..Since the publication of the Asia-Pacific GERD consensus in 2004, more data concerning the epidemiology and management of gastroesophageal reflux disease (GERD) have emerged. An evidence based review and update was needed... - Mechanisms of disease: genetics of functional gastrointestinal disorders--searching the genes that matterBirgit Adam
Nerve Gut Research Laboratory, Department of Gastroenterology and Hepatology at the Royal Adelaide Hospital, SA, Australia
Nat Clin Pract Gastroenterol Hepatol 4:102-10. 2007..In the presence of specific hereditary factors, environmental factors that do not usually cause long-term functional alterations are linked to the manifestation of symptoms... - (Post) inflammatory visceral hyperalgesia: don't we believe what we don't see?Gerald Holtmann
Gastroenterology 122:823-5. 2002 - Functional gastroduodenal disordersJan Tack
Department of Gastroenterology, University Hospitals Leuven, Leuven, Belgium
Gastroenterology 130:1466-79. 2006..The proposed classification requires further research and careful validation but the criteria should be of value for clinical practice; for epidemiological, pathophysiological, and clinical management studies; and for drug development... - MR colonography with barium-based fecal tagging: initial clinical experienceThomas C Lauenstein
Department of Diagnostic Radiology, University Hospital Essen, Hufelandstrasse 55, D-45122 Essen, Germany
Radiology 223:248-54. 2002..Thus, sensitivity of MR colonography was 89.3% (25 of 28) for lesions and 91.7% (22 of 24) for patients. CONCLUSION: Barium-tagged MR colonography obviates bowel cleansing and depicts all lesions exceeding 8 mm in diameter...