Gerald Holtmann

Summary

Affiliation: University of Essen
Country: Germany

Publications

  1. ncbi request reprint [Significance of esophagocardiac reflexes for inducing thoracic pain]
    G Holtmann
    Abteilung für Gastroenterologie und Hepatologie, Universitatsklinikum Essen
    Herz 24:154-7. 1999
  2. ncbi request reprint Molecular basis of functional gastrointestinal disorders
    Gerald Holtmann
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Essen, Hufelandstr 55, 45122 Essen, Germany
    Best Pract Res Clin Gastroenterol 18:633-40. 2004
  3. ncbi request reprint G-protein beta 3 subunit 825 CC genotype is associated with unexplained (functional) dyspepsia
    Gerald Holtmann
    Gastroenterology and Hepatology, University of Essen, Germany
    Gastroenterology 126:971-9. 2004
  4. ncbi request reprint IBS: a syndrome or many diseases?
    Gerald Holtmann
    Department of Gastroenterology, Hepatology and General Internal Medicine, Royal Adelaide Hospital, University of Adelaide, North Terrace, South Australia 5000, Adelaide, Australia
    Best Pract Res Clin Gastroenterol 18:91-7. 2004
  5. ncbi request reprint Review article: management of peptic ulcer bleeding-the roles of proton pump inhibitors and Helicobacter pylori eradication
    G Holtmann
    University of Essen, Department of Gastroenterology, Hufelandstr 55, D 45122, Essen, Germany
    Aliment Pharmacol Ther 19:66-70. 2004
  6. ncbi request reprint Efficacy of artichoke leaf extract in the treatment of patients with functional dyspepsia: a six-week placebo-controlled, double-blind, multicentre trial
    G Holtmann
    Division of Internal Medicine, Department of Gastroenterology, University of Essen, Germany
    Aliment Pharmacol Ther 18:1099-105. 2003
  7. ncbi request reprint Clinical presentation and personality factors are predictors of the response to treatment in patients with functional dyspepsia; a randomized, double-blind placebo-controlled crossover study
    Gerald Holtmann
    Department of Gastroenterology and Hepatology, University of Essen, Essen, Germany
    Dig Dis Sci 49:672-9. 2004
  8. ncbi request reprint Do changes in visceral sensory function determine the development of dyspepsia during treatment with aspirin?
    Gerald Holtmann
    Division of Gastroenterology and Hepatology, University of Essen, Essen, Germany
    Gastroenterology 123:1451-8. 2002
  9. ncbi request reprint A randomized placebo-controlled trial of simethicone and cisapride for the treatment of patients with functional dyspepsia
    G Holtmann
    Division of Gastroenterology and Hepatology, University of Essen, Germany
    Aliment Pharmacol Ther 16:1641-8. 2002
  10. pmc Differences in gastric mechanosensory function after repeated ramp distensions in non-consulters with dyspepsia and healthy controls
    G Holtmann
    Division of Gastroenterology and Hepatology, University of Essen, Germany
    Gut 47:332-6. 2000

Detail Information

Publications84

  1. ncbi request reprint [Significance of esophagocardiac reflexes for inducing thoracic pain]
    G Holtmann
    Abteilung für Gastroenterologie und Hepatologie, Universitatsklinikum Essen
    Herz 24:154-7. 1999
    ..The available data convincingly demonstrate a reduction of the exertional angina threshold and changes of the ECG (ST segment depression and arrhythmia). These effects are most likely due to a reduced coronary blood flow...
  2. ncbi request reprint Molecular basis of functional gastrointestinal disorders
    Gerald Holtmann
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Essen, Hufelandstr 55, 45122 Essen, Germany
    Best Pract Res Clin Gastroenterol 18:633-40. 2004
    ..Thus, relevant polymorphisms of genes with immunmodulating and/or neuromodulating features (OPRM1, IL-4, IL-4R, TNFalpha) may also play a role in the manifestation of FGIDs...
  3. ncbi request reprint G-protein beta 3 subunit 825 CC genotype is associated with unexplained (functional) dyspepsia
    Gerald Holtmann
    Gastroenterology and Hepatology, University of Essen, Germany
    Gastroenterology 126:971-9. 2004
    ..We aimed to assess the association of specific G-protein beta 3 subunit genotypes with functional dyspepsia...
  4. ncbi request reprint IBS: a syndrome or many diseases?
    Gerald Holtmann
    Department of Gastroenterology, Hepatology and General Internal Medicine, Royal Adelaide Hospital, University of Adelaide, North Terrace, South Australia 5000, Adelaide, Australia
    Best Pract Res Clin Gastroenterol 18:91-7. 2004
    ..Thus, it is reasonable to anticipate that IBS will be dissected accordingly and our disease concepts will accept the irritable bowel syndrome as the clinical manifestation of a number of different disorders...
  5. ncbi request reprint Review article: management of peptic ulcer bleeding-the roles of proton pump inhibitors and Helicobacter pylori eradication
    G Holtmann
    University of Essen, Department of Gastroenterology, Hufelandstr 55, D 45122, Essen, Germany
    Aliment Pharmacol Ther 19:66-70. 2004
    ..e. Helicobacter pylori infection, use of aspirin or nonsteroidal anti-inflammatory drugs). Elimination or modification of these risk factors reduces the risk of ulcer recurrence and, hence, of recurrent ulcer bleeding...
  6. ncbi request reprint Efficacy of artichoke leaf extract in the treatment of patients with functional dyspepsia: a six-week placebo-controlled, double-blind, multicentre trial
    G Holtmann
    Division of Internal Medicine, Department of Gastroenterology, University of Essen, Germany
    Aliment Pharmacol Ther 18:1099-105. 2003
    ..This study aimed to assess the efficacy of artichoke leaf extract (ALE) in the treatment of patients with functional dyspepsia (FD)...
  7. ncbi request reprint Clinical presentation and personality factors are predictors of the response to treatment in patients with functional dyspepsia; a randomized, double-blind placebo-controlled crossover study
    Gerald Holtmann
    Department of Gastroenterology and Hepatology, University of Essen, Essen, Germany
    Dig Dis Sci 49:672-9. 2004
    ..1-0.9). Symptom pattern and psychological disturbances are independent predictors of treatment response. Patients with reflux-like symptoms and greater psychological disturbances are more likely to respond to an acid-lowering compound...
  8. ncbi request reprint Do changes in visceral sensory function determine the development of dyspepsia during treatment with aspirin?
    Gerald Holtmann
    Division of Gastroenterology and Hepatology, University of Essen, Essen, Germany
    Gastroenterology 123:1451-8. 2002
    ..We hypothesized that the development of dyspeptic symptoms during treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) would be linked to alterations in gastric mechanosensory function and gastric emptying...
  9. ncbi request reprint A randomized placebo-controlled trial of simethicone and cisapride for the treatment of patients with functional dyspepsia
    G Holtmann
    Division of Gastroenterology and Hepatology, University of Essen, Germany
    Aliment Pharmacol Ther 16:1641-8. 2002
    ..To compare the efficacy of simethicone with placebo and the prokinetic cisapride in patients with functional dyspepsia...
  10. pmc Differences in gastric mechanosensory function after repeated ramp distensions in non-consulters with dyspepsia and healthy controls
    G Holtmann
    Division of Gastroenterology and Hepatology, University of Essen, Germany
    Gut 47:332-6. 2000
    ..Decreased rectal thresholds following sigmoid mechanical stimulation have been observed in irritable bowel but this mechanism has not been evaluated in functional dyspepsia...
  11. ncbi request reprint A randomized, double-blind, comparative study of standard-dose rabeprazole and high-dose omeprazole in gastro-oesophageal reflux disease
    G Holtmann
    Department of Gastroenterology and Hepatology, University of Essen, Essen, Germany
    Aliment Pharmacol Ther 16:479-85. 2002
    ..Rabeprazole has a faster onset of antisecretory action than omeprazole, and it is of interest to determine whether this translates into faster symptom relief in patients with gastro-oesophageal reflux disease...
  12. ncbi request reprint Reflux disease: the disorder of the third millennium
    G Holtmann
    Department of Gastroenterology, University of Essen, Germany
    Eur J Gastroenterol Hepatol 13:S5-11. 2001
    ..Treatment of GORD in the future will require effective techniques to control symptoms, maintain remission, and prevent complications in the affected patient...
  13. ncbi request reprint Randomised double-blind comparison of simethicone with cisapride in functional dyspepsia
    G Holtmann
    Division of Gastroenterology, University of Essen, Germany
    Aliment Pharmacol Ther 13:1459-65. 1999
    ..To compare the efficacy of simethicone with cisapride in patients with functional (non-ulcer) dyspepsia...
  14. ncbi request reprint Gastric Helicobacter pylori infection accelerates healing of reflux esophagitis during treatment with the proton pump inhibitor pantoprazole
    G Holtmann
    Department of Gastroenterology and Hepatology, University of Essen, Essen, Germany
    Gastroenterology 117:11-6. 1999
    ..pylori-infected patients than in patients without H. pylori infection...
  15. ncbi request reprint Psychological stress and the severity of post-inflammatory visceral hyperalgesia
    Tobias Liebregts
    Royal Adelaide Hospital, Department of Gastroenterology, Hepatology and General Medicine, University of Adelaide, North Terrace, Adelaide, SA 5000, Australia
    Eur J Pain 11:216-22. 2007
    ..Stress and inflammation contribute to this altered visceral sensory function. We aimed to elucidate the role of repetitive stress and acute mucosal inflammation, alone and in combination, on sensory function...
  16. ncbi request reprint Severity of mucosal inflammation as a predictor for alterations of visceral sensory function in a rat model
    Birgit Adam
    Royal Adelaide Hospital, Department of Gastroenterology, Hepatology and General Medicine, University of Adelaide, Australia
    Pain 123:179-86. 2006
    ..Visceral hyperalgesia occurs after a transient colitis. However, even a mild acute but asymptomatic colitis can induce long-lasting visceral hyperalgesia in the presence of additional stimuli...
  17. pmc The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli
    Stuart M Brierley
    Nerve Gut Research Laboratory, Department of Gastroenterology and Hepatology, Hanson Institute, Royal Adelaide Hospital, Adelaide, South Australia, Australia
    Gastroenterology 137:2084-2095.e3. 2009
    ..Sensory information from the GI tract is conducted via 5 afferent subtypes along 3 pathways...
  18. ncbi request reprint A combination of peppermint oil and caraway oil attenuates the post-inflammatory visceral hyperalgesia in a rat model
    Birgit Adam
    Department of Gastroenterology, Hepatology and General Medicine, University of Adelaide, Royal Adelaide Hospital, Adelaide, South Australia, Australia
    Scand J Gastroenterol 41:155-60. 2006
    ..Thus, the aim of this study was to characterize the effects of peppermint- and caraway oil, individually and in combination, on visceral nociception in a rat model of post-inflammatory visceral hyperalgesia...
  19. ncbi request reprint Recombinant human erythropoietin counteracts cisplatin-induced visceral hyperalgesia
    Min Suk Yoon
    Department of Neurology, University of Duisburg Essen, Essen, Germany
    Neurosci Bull 26:282-8. 2010
    ..The present study was aimed to investigate the effect of recombinant human erythropoietin (rhEPO) on cisplatin-induced visceral hyperalgesia...
  20. pmc Selective role for TRPV4 ion channels in visceral sensory pathways
    Stuart M Brierley
    Discipline of Physiology, School of Molecular and Biomedical Sciences, The University of Adelaide, Adelaide, Australia
    Gastroenterology 134:2059-69. 2008
    ..Here, we show that colonic afferents express a specific molecular transducer that underlies their specialized mechanosensory function: the transient receptor potential channel, vanilloid 4 (TRPV4)...
  21. ncbi request reprint Public speaking stress-induced neuroendocrine responses and circulating immune cell redistribution in irritable bowel syndrome
    Sigrid Elsenbruch
    Department of Medical Psychology, University Hospital of Essen Medical School, Essen, Germany
    Am J Gastroenterol 101:2300-7. 2006
    ....
  22. ncbi request reprint Immune activation in patients with irritable bowel syndrome
    Tobias Liebregts
    Department of Gastroenterology and Hepatology, University of Adelaide, Royal Adelaide Hospital, South Australia, Australia
    Gastroenterology 132:913-20. 2007
    ..We further aimed to explore whether symptoms and psychiatric comorbidity in IBS are linked to the release of proinflammatory cytokines...
  23. ncbi request reprint Heartburn in primary care: problems below the surface
    Gerald Holtmann
    Division of Internal Medicine, Department of Gastroenterology and Hepatology, University of Essen, Essen, Germany
    J Gastroenterol 39:1027-34. 2004
    ..This review discusses the symptoms and risk factors associated with GERD, possible links to Helicobacter pylori infection, and effective treatment strategies within a primary care setting...
  24. ncbi request reprint Host immune response determines visceral hyperalgesia in a rat model of post-inflammatory irritable bowel syndrome
    Birgit Adam
    Department of Bone Marrow Transplantation, University Hospital Essen, University Duisburg Essen, West German Cancer Center, Hufelandstr 55, 45122, Essen, Germany
    J Gastroenterol 48:1119-27. 2013
    ..We aimed to investigate this concept by characterizing visceral sensitivity in two rat strains, following a chemically induced colitis...
  25. doi request reprint Sensory neuro-immune interactions differ between irritable bowel syndrome subtypes
    Patrick A Hughes
    Nerve Gut Research Laboratory, Discipline of Medicine, Faculty of Health Sciences, The University of Adelaide and Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, Adelaide, South Australia, Australia 5000
    Gut 62:1456-65. 2013
    ..Here we show how this dysfunction differs between major IBS subgroups and how immunocytes communicate with sensory nerves...
  26. ncbi request reprint [Evidence-based medicine and phytotherapy for functional dyspepsia and irritable bowel syndrome: a systematic analysis of evidence for the herbal preparation Iberogast]
    Gerald Holtmann
    Departament of Gastroenterology, Hepatology and General Medicine, Royal Adelaide Hospital, University of Adelaide, Adelaide, South Australia, Australien
    Wien Med Wochenschr 154:528-34. 2004
    ..In this context, same standards apply as for conventional chemically defined medications...
  27. ncbi request reprint Psychological comorbidity and complexity of gastrointestinal symptoms in clinically diagnosed irritable bowel syndrome patients
    Antonina Mikocka-Walus
    Discipline of General Practice and School of Psychology, University of Adelaide, Adelaide, South Australia, Australia
    J Gastroenterol Hepatol 23:1137-43. 2008
    ....
  28. ncbi request reprint A placebo-controlled trial of itopride in functional dyspepsia
    Gerald Holtmann
    Department of Gastroenterology, Hepatology and General Medicine, Royal Adelaide Hospital and University of Adelaide, Adelaide, SA, Australia
    N Engl J Med 354:832-40. 2006
    ..The treatment of patients with functional dyspepsia remains unsatisfactory. We assessed the efficacy of itopride, a dopamine D2 antagonist with anti-acetylcholinesterase [corrected] effects, in patients with functional dyspepsia...
  29. ncbi request reprint On-demand treatment of acute heartburn with the antacid hydrotalcite compared with famotidine and placebo: randomized double-blind cross-over study
    Wolfgang Holtmeier
    Department of Gastroenterology, Med Klinik I, J W Goethe Universitat, Frankfurt, Australia
    J Clin Gastroenterol 41:564-70. 2007
    ..Antacids are widely used in the self-treatment of gastroesophageal reflux-induced complaints, but respective studies are lacking...
  30. doi request reprint Failed therapy and directions for the future in dyspepsia
    Gerald Holtmann
    Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, University of Adelaide, Adelaide, Australia
    Dig Dis 26:218-24. 2008
    ..However, a very careful assessment of potential risks and benefits needs to be undertaken on a case-by-case basis. Other evidence-based measures include psychological interventions such as psychotherapy and hypnotherapy...
  31. ncbi request reprint Effects of a fixed combination of peppermint oil and caraway oil on symptoms and quality of life in patients suffering from functional dyspepsia
    Gerald Holtmann
    University of Essen, Department of Gastroenterology and Hepatology, Essen, Germany
    Phytomedicine 10:56-7. 2003
  32. pmc Guideline adherence and patient satisfaction in the treatment of inflammatory bowel disorders--an evaluation study
    Claudia Pieper
    Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, Essen, Germany
    BMC Health Serv Res 9:17. 2009
    ..Thus the aim of this study was to identify variables that influence quality of treatment and quality of life as well as patient satisfaction...
  33. doi request reprint Onset of relief of symptoms of gastroesophageal reflux disease: post hoc analysis of two previously published studies comparing pantoprazole 20 mg once daily with nizatidine or ranitidine 150 mg twice daily
    Sebastian Haag
    Department of Gastroenterology and Hepatology, University Hospital of Essen, Essen, Germany
    Clin Ther 32:678-90. 2010
    ..Systematic assessments of the onset of symptom relief in the treatment of gastroesophageal reflux disease (GERD) are lacking...
  34. doi request reprint Functional dyspepsia is associated with a greater symptomatic response to fat but not carbohydrate, increased fasting and postprandial CCK, and diminished PYY
    Amelia N Pilichiewicz
    University of Adelaide Discipline of Medicine, Royal Adelaide Hospital, Adelaide, Australia
    Am J Gastroenterol 103:2613-23. 2008
    ....
  35. ncbi request reprint Reflux disease and Barrett's esophagus
    S Haag
    Dept of Gastroenterology and Hepatology, Institute of Internal Medicine, University of Essen, Essen, Germany
    Endoscopy 35:112-7. 2003
    ..For this reason, it is justifiable to carry out curative endoscopic resection. Mucosal ablation procedures may also be appropriate, but these still need to be properly investigated in clinical trials...
  36. ncbi request reprint Understanding GERD symptoms in the clinical setting
    Gerald Holtmann
    Department of Gastroenterology, Hepatology and General Medicine, Royal Adelaide Hospital, Adelaide, Australia
    Drugs Today (Barc) 41:13-7. 2005
    ..Proper symptom assessment as a measure of the severity of disease and for the evaluation of treatment response is required, as are symptom assessment tools for practical clinical use...
  37. doi request reprint Serotoninergic and non-serotoninergic effects of two tricyclic antidepressants on visceral nociception in a rat model
    Lars P Bechmann
    Department of Gastroenterology, University of Essen, Germany
    Scand J Gastroenterol 44:680-6. 2009
    ..The aim of this study was to compare the antinociceptive effects of different TCAs...
  38. ncbi request reprint MR colonography in patients with incomplete conventional colonoscopy
    Waleed Ajaj
    Department of Diagnostic and Interventional Radiology, University Hospital Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Radiology 234:452-9. 2005
    ..To assess dark-lumen magnetic resonance (MR) colonography for the evaluation of colonic segments in patients in whom conventional colonoscopy could not be completed...
  39. ncbi request reprint Colonic transit studies with 99mTc-rhenium sulfide colloid in live rats. A preliminary study
    Chris Tsopelas
    RAH Radiopharmacy, Nuclear Medicine Department, Royal Adelaide Hospital, North Terrace, Adelaide 5000, South Australia
    Hell J Nucl Med 11:96-100. 2008
    ..These results suggest this is a reliable technique of measuring regional colonic transit as a measure of colonic motility in normal rats. This methodology might be well suited to screen potential motility effects of drug candidates...
  40. doi request reprint Guidance on the use of over-the-counter proton pump inhibitors for the treatment of GERD
    Gerald Holtmann
    Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, University of Adelaide, Adelaide, SA, Australia
    Int J Clin Pharm 33:493-500. 2011
    ..The aim of this paper was to develop a guideline on the over-the-counter management of gastroesophageal reflux disease with proton pump inhibitors (i.e. omeprazole)...
  41. ncbi request reprint Effects of Iberogast on proximal gastric volume, antropyloroduodenal motility and gastric emptying in healthy men
    Amelia N Pilichiewicz
    University of Adelaide Discipline of Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia
    Am J Gastroenterol 102:1276-83. 2007
    ..The effects of Iberogast on the human gastrointestinal tract have not been evaluated...
  42. doi request reprint Recurrent symptoms after fundoplication with a negative pH study--recurrent reflux or functional heartburn?
    Sarah K Thompson
    Discipline of Surgery, University of Adelaide, Adelaide, South Australia, Australia
    J Gastrointest Surg 13:54-60. 2009
    ..The aim of our study is to determine whether these patients have an associated functional disorder or abnormal cytokine activity and to examine the reproducibility of pH testing...
  43. doi request reprint Management of reflux symptoms with over-the-counter proton pump inhibitors: issues and proposed guidelines
    Sebastian Haag
    Department of Gastroenterology and Hepatology, University Hospital Essen, Essen, Germany
    Digestion 80:226-34. 2009
    ..For the purpose of this review, relevant papers, including national and international guidelines were reviewed and recommendations made for appropriate use of OTC proton pump inhibitor (PPI) therapy...
  44. doi request reprint Do we know what patients want? The doctor-patient communication gap in functional gastrointestinal disorders
    Joanne Collins
    School of Psychology, University of Adelaide, Adelaide, Australia
    Clin Gastroenterol Hepatol 7:1252-4, 1254.e1-2. 2009
    ..Ideally, patients and doctors would have a common understanding of the issues involved. We sought to investigate this with matched questionnaires...
  45. ncbi request reprint Intraoperative cholangioscopy in the management of biliary adenomas
    Georgios C Sotiropoulos
    Department of General Surgery and Transplantation, University Hospital Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    J Surg Oncol 85:91-2. 2004
  46. ncbi request reprint [Diagnostic criteria and therapeutic strategies of abdominal pain syndromes]
    J M Gschossmann
    Abteilung für Gastroenterologie und Hepatologie, Universitatsklinikum Essen, Germany
    Schmerz 16:476-80. 2002
    ..For these disorders no cure is currently available and treatment is targeted towards relief of symptoms only...
  47. ncbi request reprint [Epidemiology and clinical phenomenology of visceral pain]
    J M Gschossmann
    Abteilung für Gastroenterologie und Hepatologie, Universitatsklinikum Essen, Germany
    Schmerz 16:447-51. 2002
    ..Functional gastrointestinal disturbances which are localized in the lower abdomen are summarized as irritable bowel syndrome. Interestingly,both functional dyspepsia and irritable bowel syndrome may overlap...
  48. pmc Real time high resolution magnetic resonance imaging for the assessment of gastric motility disorders
    W Ajaj
    Department for Diagnostic and Interventional Radiology, University Hospital Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    Gut 53:1256-61. 2004
    ..The aim of this study was to evaluate whether patients with increased or decreased gastric motility can be differentiated from healthy volunteers by means of real time magnetic resonance imaging (MRI)...
  49. pmc Symptom patterns in functional dyspepsia and irritable bowel syndrome: relationship to disturbances in gastric emptying and response to a nutrient challenge in consulters and non-consulters
    S Haag
    Department of Gastroenterology, Hepatology, and General Internal Medicine, Royal Adelaide Hospital, University of Adelaide, North Terrace, Adelaide, South Australia 5000, Australia
    Gut 53:1445-51. 2004
    ..Our aim was to assess the relationship between gastric motor and sensory function and symptom patterns in community subjects and patients with functional dyspepsia (FD) or irritable bowel syndrome (IBS)...
  50. doi request reprint An integrated model of care for inflammatory bowel disease sufferers in Australia: development and the effects of its implementation
    Antonina A Mikocka-Walus
    School of Nursing and Midwifery and Sansom Institute for Health Research, University of South Australia, Adelaide, Australia
    Inflamm Bowel Dis 18:1573-81. 2012
    ..This review describes the development of such a model and the effects of its implementation in a hospital-based cohort of patients with IBD...
  51. ncbi request reprint Effect of transient chemically induced colitis on the visceromotor response to mechanical colorectal distension
    Jürgen M Gschossmann
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Eur J Gastroenterol Hepatol 14:1067-72. 2002
    ..Acute mucosal inflammation may initiate alterations of visceral sensory function. However, experimental studies on the potential effects of a transient inflammation on visceral sensitivity are lacking...
  52. ncbi request reprint Epidemiological trends of functional gastrointestinal disorders
    J M Gschossmann
    Department of Gastroenterology and Hepatology, University of Essen, Hufelandstrasse 55, D-45122 Essen, Germany. Germany
    Dig Dis 19:189-94. 2001
    ..Thus, the available data do not provide evidence that the prevalence of these disorders has changed in recent decades...
  53. ncbi request reprint H. pylori and functional dyspepsia: increased serum antibodies as an independent risk factor?
    G Holtmann
    Department of Gastroenterology, University of Essen, Germany
    Dig Dis Sci 46:1550-7. 2001
    ..6, 95% CI 0.8-2.9) were not associated with frequent dyspepsia. In conclusion, in a subgroup of H. pylori-infected subjects who have high antibody titers, H. pylori appears to be associated with functional dyspepsia...
  54. ncbi request reprint Serum ferritin and survival of renal transplant recipients: a prospective 10-year cohort study
    Stefan Herget-Rosenthal
    Division of Gastroenterology and Hepatology, Medizinische Klinik, Universitatsklinikum Essen, Hufelandstrasse 52, 45122, Essen, Germany
    Transpl Int 16:642-7. 2003
    ..1, confidence interval (CI): 1.1-9.2; P=0.03). These data suggest that serum ferritin levels above 1100 ng/ml due to multiple blood transfusions causing iron overload is a relevant factor that increases mortality...
  55. doi request reprint Is there any association between disturbed gastrointestinal visceromotor and sensory function and impaired quality of life in functional dyspepsia?
    S Haag
    Department of Gastroenterology and Hepatology, University of Essen, Essen, Germany
    Neurogastroenterol Motil 22:262-e79. 2010
    ..CONCLUSIONS & INFERENCES In EPS and PDS, delayed gastric empting and altered sensory function are disease markers but not directly linked to the severity of HRQOL impairment or clinical presentation of FD...
  56. ncbi request reprint International validation of a health-related quality of life questionnaire in patients with erosive gastro-oesophageal reflux disease
    G Holtmann
    Department of Medicine, University of Adelaide, Adelaide, SA, Australia
    Aliment Pharmacol Ther 29:615-25. 2009
    ....
  57. ncbi request reprint Validation of the gastrointestinal symptom score for the assessment of symptoms in patients with functional dyspepsia
    B Adam
    Department of Gastroenterology, Hepatology and General Internal Medicine, Royal Adelaide Hospital, University of Adelaide, Australia
    Aliment Pharmacol Ther 22:357-63. 2005
    ..To validate the gastrointestinal symptom score as an outcome measure for functional dyspepsia...
  58. doi request reprint Impairment of health-related quality of life in functional dyspepsia and chronic liver disease: the influence of depression and anxiety
    S Haag
    Department of Gastroenterology and Hepatology, University of Essen, Essen, Germany
    Aliment Pharmacol Ther 27:561-71. 2008
    ..Data on the relative impairment of HRQOL in chronic liver disease (CLD) and functional gastrointestinal disorders are lacking and no studies have assessed the link between impairment of HRQOL and psychosocial factors yet...
  59. ncbi request reprint Is there a benefit from intensified medical and psychological interventions in patients with functional dyspepsia not responding to conventional therapy?
    S Haag
    Department of Gastroenterology and Hepatology, and Clinic for Psychosomatic Medicine and Psychotherapy, University Hospital Essen, Essen, Germany
    Aliment Pharmacol Ther 25:973-86. 2007
    ..standard medical therapy in patients with refractory functional dyspepsia (FD), referred to a tertiary referral medical center...
  60. ncbi request reprint [Functional gastrointestinal disorders]
    B Adam
    University of Adelaide, Royal Adelaide Hospital, Department of Gastroenterology, Hepatology and General Medicine, North Terrace, Adelaide, SA 5000, Australia
    Dtsch Med Wochenschr 131:2531-40, quiz 2541-4. 2006
  61. ncbi request reprint Real-time high-resolution MRI for the assessment of gastric motility: pre- and postpharmacological stimuli
    Waleed Ajaj
    Department of Diagnostic and Interventional Radiology, University Hospital Essen, Essen, Germany
    J Magn Reson Imaging 19:453-8. 2004
    ..To determine the practicality of MRI using a new real-time sequence for the assessment of gastric motion, and quantify the effects of motility-modifying substances...
  62. ncbi request reprint Are there alterations of neuroendocrine and cellular immune responses to nutrients in women with irritable bowel syndrome?
    Sigrid Elsenbruch
    Department of Medical Psychology, University Clinic of Essen, Essen, Germany
    Am J Gastroenterol 99:703-10. 2004
    ..The goal was to investigate the neuroimmune axis in irritable bowel syndrome (IBS) by analyzing the neuroendocrine and cellular immune responses to nutrient load...
  63. ncbi request reprint Review article: the patient with gastro-oesophageal reflux disease--lifestyle advice and medication
    G Holtmann
    Department of Gastroenterology, Hepatology and General Medicine, Royal Adelaide Hospital, University of Adelaide, South Australia 5000, Australia
    Aliment Pharmacol Ther 20:24-7. 2004
    ..Thus, medication is usually necessary for symptom control. Proton pump inhibitors are now mainstream treatment for the reduction of acid secretion in patients with severe manifestations and 4-week healing rates are approaching 90%...
  64. ncbi request reprint [Functional dyspepsia - diagnosis of desperation?]
    T Liebregts
    Department of Gastroenterology, Hepatology and General Medicine, Royal Adelaide Hospital, University of Adelaide, North Terrace, Adelaide, Australia
    Internist (Berl) 47:568, 570-2, 574, passim. 2006
    ..While there is currently no therapy that cures functional dyspepsia, the therapeutic target is to control symptoms...
  65. ncbi request reprint Persistently altered visceral perception after resection of an esophageal granular cell myoblastoma: a therapeutic concept revisited
    A Canbay
    Department of Medicine, Division of Gastroenterology and Hepatology, Essen University Clinic, Germany
    Z Gastroenterol 41:917-20. 2003
    ..Consequently, this case also cautions the therapeutic concept to solely relieve GCT symptoms by resection if the tumor is less than 20 mm in diameter...
  66. ncbi request reprint Prevalence of unexplained upper abdominal symptoms in patients with migraine
    T Kurth
    Department of Neurology, University Duisburg Essen, Essen, Germany, and Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Cephalalgia 26:506-10. 2006
    ..Upper abdominal symptoms are significantly more frequent in patients with migraine compared with healthy controls. The association between migraine and idiopathic upper abdominal symptoms may suggest common pathophysiological mechanisms...
  67. ncbi request reprint [Maintaining remission of ulcerative colitis with the probiotic Escherichia Coli Nissle 1917 is as effective as with standard mesalazine]
    B Adam
    Department of Gastroenterology, Hepatology and General Medicine, Royal Adelaide Hospital, University of Adelaide, Australien
    Z Gastroenterol 44:267-9. 2006
  68. ncbi request reprint Neuroendocrine and blood pressure responses to rectal distensions in individuals with high and low visceral pain sensitivity
    S Elsenbruch
    Department of Medical Psychology, University Hospital of Essen Medical School, University of Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
    Psychoneuroendocrinology 32:580-5. 2007
    ..The mechanisms of interindividual variations in visceral pain sensitivity remain poorly understood. We characterized the neuroendocrine responses to rectal distensions in healthy individuals with high vs. low rectal pain sensitivity...
  69. ncbi request reprint [Functional dyspepsia]
    S Haag
    Universitatsklinikum Essen, Medizinische Klinik und Poliklinik, Abteilung für Gastroenterologie, Essen
    MMW Fortschr Med 146:51-2. 2004
  70. ncbi request reprint Susceptibility genes and functional gastrointestinal disorders
    T Liebregts
    Department of Gastroenterology, Hepatology and General Medicine, University of Adelaide, Royal Adelaide Hospital, Adelaide, South Australia, Australia
    J Gastroenterol Hepatol 20:1792-3. 2005
  71. ncbi request reprint Effect of E. coli Nissle 1917 on post-inflammatory visceral sensory function in a rat model
    T Liebregts
    Department of Gastroenterology, Hepatology and General Medicine, University of Adelaide, Royal Adelaide Hospital, South Australia, Adelaide, Australia
    Neurogastroenterol Motil 17:410-4. 2005
    ..In a subgroup of patients, the initial manifestation is preceded by GI inflammation. Recent studies have demonstrated an improvement of inflammation and symptoms during treatment with Escherichia coli Nissle 1917 (EcN)...
  72. ncbi request reprint [Irritable bowel syndrome]
    B Adam
    Royal Adelaide Hospital, Department of Gastroenterology, Hepatology and General Medicine, University of Adelaide
    Dtsch Med Wochenschr 130:399-401. 2005
    ..At present no cure for patients with IBS exists. Thus, all currently available treatments target palliation of symptoms. This, however, may change in the future...
  73. ncbi request reprint GERD 2003 -- a consensus on the way ahead
    Steven F Moss
    Brown University, Providence, R I, USA
    Digestion 67:111-7. 2003
    ..Intestinal metaplasia in the lower esophagus is probably very common. Whether and how to, first, screen for, and then, perform surveillance in Barrett's esophagus remains highly problematic and contentious...
  74. ncbi request reprint Papillomatosis confined to the distal biliary tract--a rare cause of obstructive jaundice: report of a case
    Georgios C Sotiropoulos
    Department of General Surgery and Transplantation, University Hospital Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    Surg Today 33:781-4. 2003
    ..When considering a radical resection, intraoperative cholangioscopy is strongly recommended to confirm any localized papillomatosis and rule out any diffuse papillomatosis of the entire biliary tract...
  75. ncbi request reprint GERD evaluation: time for a new paradigm?
    Irvin M Modlin
    Yale University School of Medicine, New Haven, CT 06520, USA
    J Clin Gastroenterol 41:237-41. 2007
    ..We propose that accurate symptom delineation complemented with endoscopy performed in selected groups of patients will become the mainstay in diagnosis of GERD and the assessment of therapy efficacy...
  76. ncbi request reprint Determinants of health-related quality of life in patients with chronic liver diseases
    Winfried Häuser
    Department of Internal Medicine I, Klinikum Saarbrücken gGmbH, Winterberg 1, D 66119, Saarbruecken, Germany
    Clin Gastroenterol Hepatol 2:157-63. 2004
    ....
  77. ncbi request reprint Increased visceral sensitivity to capsaicin after DSS-induced colitis in mice: spinal cord c-Fos expression and behavior
    Niels Eijkelkamp
    Laboratory for Psychoneuroimmunology, Univ Medical Center Utrecht, Rm KC 03 063 0, Lundlaan 6, 3584 EA Utrecht, The Netherlands
    Am J Physiol Gastrointest Liver Physiol 293:G749-57. 2007
    ....
  78. ncbi request reprint Functional gastroduodenal disorders
    Jan Tack
    Department of Gastroenterology, University Hospitals Leuven, Leuven, Belgium
    Gastroenterology 130:1466-79. 2006
    ..The proposed classification requires further research and careful validation but the criteria should be of value for clinical practice; for epidemiological, pathophysiological, and clinical management studies; and for drug development...
  79. doi request reprint Asia-Pacific consensus on the management of gastroesophageal reflux disease: update
    Kwong Ming Fock
    Division of Gastroenterology, Department of Medicine, Changi General Hospital, Singapore
    J Gastroenterol Hepatol 23:8-22. 2008
    ..Since the publication of the Asia-Pacific GERD consensus in 2004, more data concerning the epidemiology and management of gastroesophageal reflux disease (GERD) have emerged. An evidence based review and update was needed...
  80. ncbi request reprint MR colonography with barium-based fecal tagging: initial clinical experience
    Thomas C Lauenstein
    Department of Diagnostic Radiology, University Hospital Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    Radiology 223:248-54. 2002
    ..To assess a strategy for fecal tagging with barium sulfate as an inexpensive tagging agent in conjunction with magnetic resonance (MR) colonography in patients suspected of having colorectal lesions...
  81. ncbi request reprint Mechanisms of disease: genetics of functional gastrointestinal disorders--searching the genes that matter
    Birgit Adam
    Nerve Gut Research Laboratory, Department of Gastroenterology and Hepatology at the Royal Adelaide Hospital, SA, Australia
    Nat Clin Pract Gastroenterol Hepatol 4:102-10. 2007
    ..In the presence of specific hereditary factors, environmental factors that do not usually cause long-term functional alterations are linked to the manifestation of symptoms...
  82. ncbi request reprint Time-resolved three-dimensional MR imaging of gastric emptying modified by IV administration of erythromycin
    Thomas C Lauenstein
    Department of Diagnostic Radiology, University Hospital Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    AJR Am J Roentgenol 180:1305-10. 2003
    ..The aim of our study was to assess the effect of IV erythromycin on gastric emptying and subsequent small-bowel filling using three-dimensional (3D) MR imaging in both healthy subjects and patients with functional dyspepsia...
  83. ncbi request reprint (Post) inflammatory visceral hyperalgesia: don't we believe what we don't see?
    Gerald Holtmann
    Gastroenterology 122:823-5. 2002
  84. ncbi request reprint Hypothesis driven research and molecular mechanisms in functional dyspepsia: the beginning of a beautiful friendship in research and practice?
    Gerald Holtmann
    Am J Gastroenterol 101:593-5. 2006
    ....