Margrit Hollborn

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. ncbi request reprint Expression of HB-EGF by retinal pigment epithelial cells in vitreoretinal proliferative disease
    Margrit Hollborn
    Department of Ophthalmology and Eye Clinic, University of Leipzig, Leipzig, Germany
    Curr Eye Res 31:863-74. 2006
  2. ncbi request reprint Positive feedback regulation between MMP-9 and VEGF in human RPE cells
    Margrit Hollborn
    Department of Ophthalmology and Eye Clinic, University of Leipzig Faculty of Medicine, Leipzig, Germany
    Invest Ophthalmol Vis Sci 48:4360-7. 2007
  3. doi request reprint Transcriptional regulation of aquaporins in the ischemic rat retina: upregulation of aquaporin-9
    Margrit Hollborn
    Department of Ophthalmology and Eye Clinic, University of Leipzig, Leipzig, Germany
    Curr Eye Res 37:524-31. 2012
  4. pmc Cytotoxic effects of curcumin in human retinal pigment epithelial cells
    Margrit Hollborn
    Department of Ophthalmology and Eye Hospital, University of Leipzig, Leipzig, Germany
    PLoS ONE 8:e59603. 2013
  5. doi request reprint Activated blood coagulation factor X (FXa) induces angiogenic growth factor expression in human retinal pigment epithelial cells
    Margrit Hollborn
    Department of Ophthalmology and Eye Hospital, University of Leipzig, Leipzig, Germany
    Invest Ophthalmol Vis Sci 53:5930-9. 2012
  6. doi request reprint Transcriptional regulation of aquaporin-3 in human retinal pigment epithelial cells
    Margrit Hollborn
    Department of Ophthalmology and Eye Hospital, Faculty of Medicine, University of Leipzig, Liebigstrasse 10 14, 04103 Leipzig, Germany
    Mol Biol Rep 39:7949-56. 2012
  7. ncbi request reprint Signaling pathways involved in PDGF-evoked cellular responses in human RPE cells
    Margrit Hollborn
    Department of Ophthalmology and Eye Clinic, University of Leipzig Medical Faculty, 04103 Leipzig, Germany
    Biochem Biophys Res Commun 344:912-9. 2006
  8. pmc The human Müller cell line MIO-M1 expresses opsins
    Margrit Hollborn
    Department of Ophthalmology and Eye Hospital, University of Leipzig, Leipzig, Germany
    Mol Vis 17:2738-50. 2011
  9. doi request reprint Effects of thrombin on RPE cells are mediated by transactivation of growth factor receptors
    Margrit Hollborn
    Department of Ophthalmology and Eye Hospital, Center of Clinical Research IZKF, University of Leipzig, Leipzig, Germany
    Invest Ophthalmol Vis Sci 50:4452-9. 2009
  10. doi request reprint Expression of aquaporins in the retina of diabetic rats
    Margrit Hollborn
    Department of Ophthalmology and Eye Hospital, University of Leipzig, Leipzig, Germany
    Curr Eye Res 36:850-6. 2011

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Expression of HB-EGF by retinal pigment epithelial cells in vitreoretinal proliferative disease
    Margrit Hollborn
    Department of Ophthalmology and Eye Clinic, University of Leipzig, Leipzig, Germany
    Curr Eye Res 31:863-74. 2006
    ..The stimulating effect on the secretion of VEGF may suggest that HB-EGF is also implicated in the pathological angiogenesis of the retina...
  2. ncbi request reprint Positive feedback regulation between MMP-9 and VEGF in human RPE cells
    Margrit Hollborn
    Department of Ophthalmology and Eye Clinic, University of Leipzig Faculty of Medicine, Leipzig, Germany
    Invest Ophthalmol Vis Sci 48:4360-7. 2007
    ..They also sought to determine the effects of MMPs on cellular proliferation and migration and the effect of triamcinolone acetonide on MMP-9-evoked cellular responses...
  3. doi request reprint Transcriptional regulation of aquaporins in the ischemic rat retina: upregulation of aquaporin-9
    Margrit Hollborn
    Department of Ophthalmology and Eye Clinic, University of Leipzig, Leipzig, Germany
    Curr Eye Res 37:524-31. 2012
    ....
  4. pmc Cytotoxic effects of curcumin in human retinal pigment epithelial cells
    Margrit Hollborn
    Department of Ophthalmology and Eye Hospital, University of Leipzig, Leipzig, Germany
    PLoS ONE 8:e59603. 2013
    ..We investigated whether curcumin alters the viability and physiological properties of human retinal pigment epithelial (RPE) cells in vitro...
  5. doi request reprint Activated blood coagulation factor X (FXa) induces angiogenic growth factor expression in human retinal pigment epithelial cells
    Margrit Hollborn
    Department of Ophthalmology and Eye Hospital, University of Leipzig, Leipzig, Germany
    Invest Ophthalmol Vis Sci 53:5930-9. 2012
    ....
  6. doi request reprint Transcriptional regulation of aquaporin-3 in human retinal pigment epithelial cells
    Margrit Hollborn
    Department of Ophthalmology and Eye Hospital, Faculty of Medicine, University of Leipzig, Liebigstrasse 10 14, 04103 Leipzig, Germany
    Mol Biol Rep 39:7949-56. 2012
    ..Activation of phospholipase A(2) is a critical factor which induces AQP3 in RPE cells...
  7. ncbi request reprint Signaling pathways involved in PDGF-evoked cellular responses in human RPE cells
    Margrit Hollborn
    Department of Ophthalmology and Eye Clinic, University of Leipzig Medical Faculty, 04103 Leipzig, Germany
    Biochem Biophys Res Commun 344:912-9. 2006
    ..The data indicate that PDGF selectively stimulates the expression of VEGF-A in RPE cells. PDGF evokes at least three signal transduction pathways which are differentially involved in various cellular responses...
  8. pmc The human Müller cell line MIO-M1 expresses opsins
    Margrit Hollborn
    Department of Ophthalmology and Eye Hospital, University of Leipzig, Leipzig, Germany
    Mol Vis 17:2738-50. 2011
    ..To determine whether the human Müller cell line Moorfields/Institute of Ophthalmology-Müller 1 (MIO-M1) expresses opsins...
  9. doi request reprint Effects of thrombin on RPE cells are mediated by transactivation of growth factor receptors
    Margrit Hollborn
    Department of Ophthalmology and Eye Hospital, Center of Clinical Research IZKF, University of Leipzig, Leipzig, Germany
    Invest Ophthalmol Vis Sci 50:4452-9. 2009
    ....
  10. doi request reprint Expression of aquaporins in the retina of diabetic rats
    Margrit Hollborn
    Department of Ophthalmology and Eye Hospital, University of Leipzig, Leipzig, Germany
    Curr Eye Res 36:850-6. 2011
    ..Here, we investigated whether experimental diabetic retinopathy in rats results in alterations of the AQP expression in the neural retina and retinal pigment epithelium (RPE)...
  11. doi request reprint Chemotactic and cytotoxic effects of minocycline on human retinal pigment epithelial cells
    Margrit Hollborn
    Department of Ophthalmology and Eye Hospital, University of Leipzig, Leipzig, Germany
    Invest Ophthalmol Vis Sci 51:2721-9. 2010
    ..To reveal the effects of minocycline, an anti-inflammatory and neuroprotective agent, on the viability and physiological properties of retinal pigment epithelial (RPE) cells and to compare the effects with those of triamcinolone acetonide...
  12. ncbi request reprint Human retinal epithelium produces and responds to placenta growth factor
    Margrit Hollborn
    Department of Ophthalmology, Eye Clinic, University of Leipzig Medical Faculty, Liebigstrasse 10 14, 04103 Leipzig, Germany
    Graefes Arch Clin Exp Ophthalmol 244:732-41. 2006
    ..In addition, we determined whether the cells express receptors for PlGF, i.e. flt-1 and neuropilins...
  13. ncbi request reprint Characterization of the basic fibroblast growth factor-evoked proliferation of the human Müller cell line, MIO-M1
    Margrit Hollborn
    Department of Ophthalmology and Eye Clinic, University of Leipzig, Liebigstrasse 10 14, 04103, Leipzig, Germany
    Graefes Arch Clin Exp Ophthalmol 242:414-22. 2004
    ..In addition, we investigated whether bFGF evoked the release of vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) from the cells...
  14. ncbi request reprint Changes in retinal gene expression in proliferative vitreoretinopathy: glial cell expression of HB-EGF
    Margrit Hollborn
    Department of Ophthalmology, University Eye Hospital, University of Leipzig, Leipzig, Germany
    Mol Vis 11:397-413. 2005
    ....
  15. ncbi request reprint Expression of LRP1 in retinal pigment epithelial cells and its regulation by growth factors
    Margrit Hollborn
    Department of Ophthalmology, Paul Flechsig Institute for Brain Research, University of Leipzig, Leipzig, Germany
    Invest Ophthalmol Vis Sci 45:2033-8. 2004
    ..The purpose of this study was to investigate the expression of this receptor and its regulation, at the protein and mRNA levels, in human (h)RPE cells...
  16. doi request reprint Retinal gene expression and Müller cell responses after branch retinal vein occlusion in the rat
    Matus Rehak
    Department of Ophthalmology and Eye Hospital, University of Leipzig Faculty of Medicine, Liebigstrasse 10 14, 04103 Leipzig, Germany
    Invest Ophthalmol Vis Sci 50:2359-67. 2009
    ..In a rat model of branch retinal vein occlusion (BRVO), changes in gene expression of factors implicated in the development of retinal edema and alterations in the properties of Müller cells were determined...
  17. doi request reprint Müller cell response to blue light injury of the rat retina
    Ianors Iandiev
    Department of Ophthalmology and Eye Clinic, Translational Center for Regenerative Medicine, Faculty of Medicine, University of Leipzig, Leipzig, Germany
    Invest Ophthalmol Vis Sci 49:3559-67. 2008
    ..Because Müller cells mediate inner retinal osmohomeostasis (mainly through channel-mediated transport of potassium ions and water), the authors investigated whether these cells alter their properties in response to excessive blue light...
  18. doi request reprint Expression of CXCL8, CXCR1, and CXCR2 in neurons and glial cells of the human and rabbit retina
    Iwona Goczalik
    Paul Flechsig Institute for Brain Research, Interdisciplinary Centre for Clinical Research, Faculty of Medicine, University of Leipzig, Leipzig, Germany
    Invest Ophthalmol Vis Sci 49:4578-89. 2008
    ....
  19. doi request reprint Deletion of aquaporin-4 renders retinal glial cells more susceptible to osmotic stress
    Thomas Pannicke
    Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany
    J Neurosci Res 88:2877-88. 2010
    ..Possible implications of the data for understanding the pathophysiology of neuromyelitis optica, a human disease that has been suggested to involve serum antibodies to AQP4, are discussed...
  20. doi request reprint Effect of intravitreal anti-vascular endothelial growth factor treatment on the retinal gene expression in acute experimental central retinal vein occlusion
    Franziska Drechsler
    Department of Ophthalmology, University of Leipzig, Leipzig, Germany
    Ophthalmic Res 47:157-62. 2012
    ..To determine the effect of intravitreal bevacizumab and anti-vascular endothelial growth factor (VEGF) antibodies on the gene expression in the neural retina in a rat model of central retinal vein occlusion (CRVO)...
  21. doi request reprint Early activation of inflammation- and immune response-related genes after experimental detachment of the porcine retina
    Margrit Hollborn
    Department of Ophthalmology and Eye Clinic, Interdisciplinary Center of Clinical Research IZKF, University of Leipzig Faculty of Medicine, Leipzig, Germany
    Invest Ophthalmol Vis Sci 49:1262-73. 2008
    ..To determine early alterations in retinal gene expression in a porcine model of rhegmatogenous retinal detachment...
  22. doi request reprint Effects of intravitreal triamcinolone acetonide on retinal gene expression in a rat model of central retinal vein occlusion
    Matus Rehak
    Department of Ophthalmology and Eye Hospital, University of Leipzig, Faculty of Medicine, Liebigstrasse 10 14, 04103 Leipzig, Germany
    Graefes Arch Clin Exp Ophthalmol 249:1175-83. 2011
    ..The aim of this study was to investigate the effects of intravitreal triamcinolone acetonide on the alterations in retinal gene expression in a rat model of central retinal vein occlusion (CRVO)...
  23. doi request reprint Immunolocalization of aquaporin-6 in the rat retina
    Ianors Iandiev
    Department of Ophthalmology and Eye Hospital, University of Leipzig, 04103 Leipzig, Germany
    Neurosci Lett 490:130-4. 2011
    ..AQP6 might be involved in the glia-mediated osmo and ion regulation of the extracellular space in this layer...
  24. doi request reprint Purinergic receptor activation inhibits osmotic glial cell swelling in the diabetic rat retina
    Antje Wurm
    Paul Flechsig Institute of Brain Research, University of Leipzig, Jahnallee 59, 04109 Leipzig, Germany
    Exp Eye Res 87:385-93. 2008
    ..Whereas adenosine is liberated via facilitated transport in control retinas, an extracellular formation of adenosine contributes to the effect of triamcinolone in diabetic retinas...
  25. ncbi request reprint Glial cell expression of hepatocyte growth factor in vitreoretinal proliferative disease
    Margrit Hollborn
    Department of Ophthalmology, University Eye Clinic, Leipzig, Germany
    Lab Invest 84:963-72. 2004
    ..The results suggest an autocrine/paracrine role of HGF in glial cell responses during proliferative vitreoretinal disorders as well as in retinal neovascularization, by stimulating of VEGF release...
  26. ncbi request reprint Differential regulation of Kir4.1 and Kir2.1 expression in the ischemic rat retina
    Ianors Iandiev
    Paul Flechsig Institute of Brain Research, University of Leipzig Medical Faculty, Jahnallee 59, 04109 Leipzig, Germany
    Neurosci Lett 396:97-101. 2006
    ..1 mRNA was not altered. The data suggest that the glial expression of distinct Kir channels is differentially regulated after retinal ischemia, with deletarious consequences for K+ ion and water homeostasis...
  27. doi request reprint Purinergic signaling involved in Müller cell function in the mammalian retina
    Antje Wurm
    Paul Flechsig Institute of Brain Research, University of Leipzig, 04109 Leipzig, Germany
    Prog Retin Eye Res 30:324-42. 2011
    ..Pharmacological modulation of purinergic receptors of Müller cells may have clinical importance, e.g., for the clearance of retinal edema and for the inhibition of dysregulated cell proliferation in proliferative retinopathies...
  28. doi request reprint Localization of glial aquaporin-4 and Kir4.1 in the light-injured murine retina
    Ianors Iandiev
    Department of Ophthalmology and Eye Hospital, University of Leipzig Faculty of Medicine, Liebigstr 10 14, D 04103 Leipzig, Germany
    Neurosci Lett 434:317-21. 2008
    ..1 and aquaporin-4 proteins; this alteration is thought to be a response to the edema in the outer retina and may support the resolution of edema...
  29. ncbi request reprint Proliferative gliosis causes mislocation and inactivation of inwardly rectifying K(+) (Kir) channels in rabbit retinal glial cells
    Elke Ulbricht
    Paul Flechsig Institute of Brain Research, University of Leipzig Faculty of Medicine, Jahnallee 59, Leipzig, Germany
    Exp Eye Res 86:305-13. 2008
    ....
  30. doi request reprint Effects of intravitreal bevacizumab (Avastin) on the porcine retina
    Ianors Iandiev
    Klinik und Poliklinik für Augenheilkunde, Universitat Leipzig, Liebigstraße 10 14, 04103, Leipzig, Germany
    Graefes Arch Clin Exp Ophthalmol 249:1821-9. 2011
    ..1, aquaporin-1, aquaporin-4)...
  31. doi request reprint Involvement of oxidative stress and mitochondrial dysfunction in the osmotic swelling of retinal glial cells from diabetic rats
    Katja Krügel
    Paul Flechsig Institute of Brain Research, University of Leipzig, Jahnallee 59, 04109 Leipzig, Germany
    Exp Eye Res 92:87-93. 2011
    ..The data suggest that oxidative stress produced by xanthine oxidase, as well as the mitochondria, are implicated in the induction of osmotic swelling of Müller cells from diabetic rats...
  32. ncbi request reprint Contrary effects of cytokines on mRNAs of cell cycle- and ECM-related proteins in hRPE cells in vitro
    Margrit Hollborn
    Department of Ophthalmology, Faculty of Medicine, University of Leipzig, Leipzig, Germany
    Curr Eye Res 28:215-23. 2004
    ....
  33. ncbi request reprint Diversity of aquaporin mRNA expressed by rat and human retinas
    Solveig Tenckhoff
    Department of Ophthalmology and Eye Clinic, University of Leipzig Medical Faculty, Liebigstr 10 14, D 04103 Leipzig, Germany
    Neuroreport 16:53-6. 2005
    ..The data suggest that the development of proliferative gliosis is accompanied by disturbed transglial water and ion movements...
  34. doi request reprint Cellular signaling and factors involved in Müller cell gliosis: neuroprotective and detrimental effects
    Andreas Bringmann
    Department of Ophthalmology and Eye Hospital, University of Leipzig, Liebigstrasse 10 14, D 04103 Leipzig, Germany
    Prog Retin Eye Res 28:423-51. 2009
    ....
  35. doi request reprint Reactive glial cells: increased stiffness correlates with increased intermediate filament expression
    Yun Bi Lu
    Division of Soft Matter Physics, Department of Physics, and Paul Flechsig Institute of Brain Research, Universitat Leipzig, Leipzig, Germany
    FASEB J 25:624-31. 2011
    ..Thus, therapeutic suppression of IF up-regulation in reactive glial cells may facilitate neuroregeneration...
  36. doi request reprint Effects of arteriolar constriction on retinal gene expression and Müller cell responses in a rat model of branch retinal vein occlusion
    Patricia Köferl
    Department of Ophthalmology, University of Leipzig, Leipzig, Germany
    Graefes Arch Clin Exp Ophthalmol 252:257-65. 2014
    ..To investigate the effect of induced arteriolar constriction (AC) on alterations in gene expression of factors implicated in the development of edema in branch retinal vein occlusion (BRVO)...
  37. ncbi request reprint Effects of the vegetable polyphenols epigallocatechin-3-gallate, luteolin, apigenin, myricetin, quercetin, and cyanidin in primary cultures of human retinal pigment epithelial cells
    Rui Chen
    Department of Ophthalmology and Eye Hospital, University of Leipzig, Leipzig, Germany
    Mol Vis 20:242-58. 2014
    ....
  38. ncbi request reprint Elevated proto-oncogene and collagen mRNA expression in PVR retinas
    Margrit Hollborn
    Department of Ophthalmology, University of Leipzig, Liebigstrasse 10 14, 04103 Leipzig, Germany
    Graefes Arch Clin Exp Ophthalmol 241:439-46. 2003
    ..Herein we investigate the messenger RNA (mRNA) expression of proto-oncogenes responsible for cell proliferation and of structural proteins that have a role in membrane formation...
  39. pmc Müller cell reactivity in response to photoreceptor degeneration in rats with defective polycystin-2
    Stefanie Vogler
    Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany
    PLoS ONE 8:e61631. 2013
    ..It is unknown whether glial activation contributes to neurovascular degeneration after photoreceptor degeneration. We characterized the reactivity of Müller glial cells in retinas of rats that express defective polycystin-2...
  40. doi request reprint Alpha2-macroglobulin inhibits the malignant properties of astrocytoma cells by impeding beta-catenin signaling
    Inge Lindner
    Institute of Biochemistry, Department of Ophthalmology, University of Leipzig, Leipzig, Germany
    Cancer Res 70:277-87. 2010
    ..Notably, LRP1 antibodies could phenocopy the effects of A2M*. Our findings suggest a pathway of tumor suppression in astrocytoma that might be tractable to therapeutic exploitation...
  41. ncbi request reprint Influence of interleukin 10 and transforming growth factor-beta on T cell stimulation through allogeneic retinal pigment epithelium cells in vitro
    Volker Enzmann
    Department of Ophthalmology and Visual Sciences, School of Medicine, University of Louisville, Louisville, KY, USA
    Ophthalmic Res 34:232-40. 2002
    ..The maximum of suppression, especially by TGF-beta, was found after 48 and 72 h of incubation. This shows that the antigen-presenting properties of human RPE cells can be altered in culture...