Genomes and Genes
Affiliation: University of Munich
- Changes in gene expression profiles in developing B cells of murine bone marrowReinhard Hoffmann
Basel Institute for Immunology, 4005 Basel, Switzerland
Genome Res 12:98-111. 2002....
- Gene expression patterns in human and mouse B cell developmentR Hoffmann
Max von Pettenkofer Institute, Ludwigs Maximilians Universität, Munchen, Germany
Curr Top Microbiol Immunol 294:19-29. 2005..This implies that care should be taken with the interpretation of gene expression data from model organisms...
- Developmental markers of B cells are superior to those of T cells for identification of stages with distinct gene expression profilesReinhard Hoffmann
Max von Pettenkofer Institut, Department Bacteriology, Munich, Germany
J Leukoc Biol 74:602-10. 2003..We conclude that the protein markers currently widely used for separating stages of B cell development better identify molecularly distinct stages than those used for separating stages of T cell development...
- A genomic view of lymphocyte developmentReinhard Hoffmann
Max von Pettenkofer Institute, Department of Bacteriology, Pettenkoferstrasser 9A, D 80336, Munchen, Germany
Curr Opin Immunol 15:239-45. 2003..Comparable stages of the T-and B-lineage developmental programs share only a few genes. By contrast, homologous genes differentially expressed during both human and mouse B-cell development have very similar expression patterns...
- Rules for gene usage inferred from a comparison of large-scale gene expression profiles of T and B lymphocyte developmentReinhard Hoffmann
Basel Institute for Immunology, Basel, Switzerland
J Immunol 170:1339-53. 2003....
- Profound effect of normalization on detection of differentially expressed genes in oligonucleotide microarray data analysisReinhard Hoffmann
Department of Bacteriology, Max von Pettenkofer Institut, Pettenkoferstrasse 9a, 80336 Munich, Germany
Genome Biol 3:RESEARCH0033. 2002..A large number of procedures for normalization and detection of differentially expressed genes have been proposed. However, the relative impact of these methods on the detection of differentially expressed genes remains to be determined...
- Role of strain differences on host resistance and the transcriptional response of macrophages to infection with Yersinia enterocoliticaKatrin van Erp
Department of Bacteriology, Max von Pettenkofer Institut, Munich, Germany
Physiol Genomics 25:75-84. 2006..These data show that host resistance factors modulate a surprisingly small, but identifiable and functionally significant, portion of the macrophage transcriptome in response to Yersinia infection...
- Alternatively activated macrophages inhibit T-cell proliferation by Stat6-dependent expression of PD-L2Silke Huber
Institute for Immunology, Ludwig Maximilians University, Munich, Germany
Blood 116:3311-20. 2010..In vivo blockade of PD-L2 during N brasiliensis infection caused an enhanced Th2 response in the lung, indicating that AAM inhibit Th2 cells by expression of PD-L2...
- Neutrality, compensation, and negative selection during evolution of B-cell development transcriptomesReinhard Hoffmann
Basel Institute for Immunology, Basel, Switzerland
Mol Biol Evol 24:2610-8. 2007..Gene expression patterns are shaped by ontogenic relationships in early and by functional specialization in later stages of development...
- Yersinia enterocolitica inactivates NK cellsIsabel Koch
Ludwig Maximilians University, Max von Pettenkofer Institut, Department of Bacteriology, 80336 Munich, Germany
Int J Med Microbiol 303:433-42. 2013..Thus, we present the first report of a bacterial pathogen inactivating NK cells, and report interaction with Tyk2-STAT4 signaling as a novel function of YopP. ..
- Bacterial toxins induce sustained mRNA expression of the silencing transcription factor klf2 via inactivation of RhoA and Rhophilin 1Kristina Dach
Department of Bacteriology, Max von Pettenkofer Institut, Pettenkoferstr 9a, 80336 Munich, Germany
Infect Immun 77:5583-92. 2009..Thus, bacteria exploit the RhoA-rhophilin signaling cascade to mediate sustained expression of the immunosuppressive transcription factor klf2...
- High-resolution gene expression profiling for simultaneous kinetic parameter analysis of RNA synthesis and decayLars Dölken
Max von Pettenkofer Institute, Ludwig Maximilians University Munich, Munich 80337, Germany
RNA 14:1959-72. 2008....
- Transcript profiling of CD16-positive monocytes reveals a unique molecular fingerprintMarion Frankenberger
Comprehensive Pneumology Center, Helmholtz Zentrum Munchen, Ludwig Maximilians University and Asklepios Fachklinik Gauting, Munich, Germany
Eur J Immunol 42:957-74. 2012..Furthermore, CD16-positive MDMs showed a higher phagocytosis for opsonized Escherichia coli. The data demonstrate that CD16-positive monocytes form a distinct type of cell, which gives rise to a distinct macrophage phenotype...
- Notch1, Notch2, and Epstein-Barr virus-encoded nuclear antigen 2 signaling differentially affects proliferation and survival of Epstein-Barr virus-infected B cellsHella Kohlhof
Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Center Munich, German Research Center for Environmental Health, Munich, Germany
Blood 113:5506-15. 2009..These findings suggest that Notch signaling in B cells and B-cell lymphomas is only compatible with proliferation if pathways leading to antiapototic signals are active...
- Strain-specific genes of Helicobacter pylori: genome evolution driven by a novel type IV secretion system and genomic island transferWolfgang Fischer
Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat, Pettenkoferstr 9a, D 80336 MUnchen, Germany
Nucleic Acids Res 38:6089-101. 2010..Thus, in addition to its natural transformation competence, conjugative transfer of genomic islands has to be considered as an important source of genetic diversity in H. pylori...
- Reduced intragraft mRNA expression of matrix metalloproteinases Mmp3, Mmp12, Mmp13 and Adam8, and diminished transplant arteriosclerosis in Ccr5-deficient miceBruno Luckow
Klinikum der Universitat Munchen, Medizinische Poliklinik Innenstadt, Munchen, Germany
Eur J Immunol 34:2568-78. 2004..We conclude that early tissue remodeling may be a critical feature in the predisposition of allografts to the development of chronic dysfunction...
- Transcriptional responses of murine macrophages to infection with Yersinia enterocoliticaReinhard Hoffmann
Max von Pettenkofer Institut, Bacteriology Department, Pettenkoferstrasse 9a, 80336 Munich, Germany
Cell Microbiol 6:377-90. 2004..We suggest that Yersinia enterocolitica might use two independent mechanisms to inhibit macrophage inflammatory responses at the transcriptional level...
- Systematic analysis of viral and cellular microRNA targets in cells latently infected with human gamma-herpesviruses by RISC immunoprecipitation assayLars Dölken
Max von Pettenkofer Institute, Ludwig Maximilians University Munich, 80336 Munich, Germany
Cell Host Microbe 7:324-34. 2010..Transcript half-life both of cellular and viral miRNA targets negatively correlated with recruitment to RISC complexes, indicating that RIP-Chip offers a quantitative estimate of miRNA function...
- Structure, chromosomal localization and expression of the mouse regulator of G-protein signaling10 gene (mRGS10)Corinne Haller
Basel Institute for Immunology, Grenzacherstrasse 487, CH 4005, Basel, Switzerland
Gene 297:39-49. 2002..Finally, mRGS10 protein was detected in plasma cells of secondary lymphoid organs by immunofluorescence...
- Cellular target genes of Epstein-Barr virus nuclear antigen 2Sabine Maier
GSF National Research Center for Environment and Health, Institute of Clinical Molecular Biology, Munich, Germany
J Virol 80:9761-71. 2006....
- Embryonic endothelial progenitor cells expressing a broad range of proangiogenic and remodeling factors enhance vascularization and tissue recovery in acute and chronic ischemiaChristian Kupatt
GSF Research Center for Environment and Health, Institute for Clinical Molecular Biology and Tumor Genetics, Munich, Germany
FASEB J 19:1576-8. 2005..Our findings show that eEPCs induce blood vessel growth and cardioprotection in severe ischemic conditions providing a readily available source to study the mechanisms of neovascularization and tissue recovery...
- Autonomous role of medullary thymic epithelial cells in central CD4(+) T cell toleranceMaria Hinterberger
Institute for Immunology, Ludwig Maximilians Universitat, Munich, Germany
Nat Immunol 11:512-9. 2010..Our data document an autonomous contribution of mTECs to both dominant and recessive mechanisms of CD4(+) T cell tolerance and support an avidity model of T(reg) cell development versus deletion...
- Antibody repertoire and gene expression profile: implications for different developmental and functional traits of splenic and peritoneal B-1 lymphocytesKarsten Kretschmer
Molecular Immunology, German Research Center for Biotechnology, Braunschweig, Germany
J Immunol 171:1192-201. 2003..Thus, splenic and peritoneal B-1a cells differ not only in their developmental program but also in functional properties...
- Helicobacter pylori vacuolating cytotoxin inhibits T lymphocyte activationBettina Gebert
Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, LMU Munchen, Germany
Science 301:1099-102. 2003..VacA partially mimicked the activity of the immunosuppressive drug FK506 by possibly inducing a local immune suppression, explaining the extraordinary chronicity of Hp infections...
- The selection of marginal zone B cells differs from that of B-1a cellsKarsten Kretschmer
Molecular Immunology, Gesellschaft für Biotechnologishe Forschung, German Research Centre for Biotechnology, Braunschweig, Germany
J Immunol 171:6495-501. 2003..Thus, our data demonstrate that despite common functional properties, MZ B and B-1a cells exhibit striking differences in their selection and/or maintenance requirements...
- Molecular signatures of self-renewal, differentiation, and lineage choice in multipotential hemopoietic progenitor cells in vitroLudovica Bruno
Section of Gene Function and Regulation, The Institute of Cancer Research, London SW3 6JB, UK
Mol Cell Biol 24:741-56. 2004..These are likely to include genes important in self-renewal, the maintenance of multipotentiality, or the negative regulation of differentiation per se...
- Common and unique gene expression signatures of human macrophages in response to four strains of Mycobacterium avium that differ in their growth and persistence characteristicsAntje Blumenthal
Division of Molecular Infection Biology, Department of Immunochemistry and Biochemical Microbiology, Research Center Borstel, Parkallee 22, D 23845 Borstel, Germany
Infect Immun 73:3330-41. 2005..TMC724, a strain of avian origin, could not be classified by any one of these schemes, possibly indicating the limits of pathogen categorization solely by immune response signatures...
- Latent membrane protein 1 of Epstein-Barr virus coordinately regulates proliferation with control of apoptosisUlrike Dirmeier
Department of Gene Vectors, GSF National Research Center for Environment and Health, Marchioninistr 25, Munich D 81377, Germany
Oncogene 24:1711-7. 2005..LMP1 does induce both pro- and antiapoptotic genes whose balance seems to permit survival during LMP1's induction and maintenance of proliferation...
- Efficient isolation and gene expression profiling of small numbers of neural crest stem cells and developing Schwann cellsJohanna Buchstaller
Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, CH 8093 Zurich, Switzerland
J Neurosci 24:2357-65. 2004..The combination of methods applied in this study should be generally useful for isolating and profiling other stem cell and difficult to isolate cell populations...
- Genetically determined susceptibility to tuberculosis in mice causally involves accelerated and enhanced recruitment of granulocytesChristine Keller
Molecular Infection Biology, Research Center Borstel, Parkallee 22, D 23845 Borstel, Germany
Infect Immun 74:4295-309. 2006..tuberculosis significantly longer than control mice. We conclude that initially enhanced recruitment of granulocytes contributes to susceptibility to tuberculosis...
- Tissue-specific induction of ADAMTS2 in monocytes and macrophages by glucocorticoidsThomas P J Hofer
Clinical Cooperation Group Inflammatory Lung Diseases GSF National Research Center for Environment and Health and Asklepios Fachkliniken München Gauting, Robert Koch Allee 29, D 82131 Gauting, Germany
J Mol Med (Berl) 86:323-32. 2008....
- Temperature-sensitive eIF5A mutant accumulates transcripts targeted to the nonsense-mediated decay pathwayRainer Schrader
Department for Protein Analytics, Max Planck Institute for Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
J Biol Chem 281:35336-46. 2006..Our data suggest that eIF5A mediates important cellular processes like cell viability and senescence through its effects on the stability of certain mRNAs...
- Dissection of transcriptional programmes in response to serum and c-Myc in a human B-cell lineIsabel Schlosser
GSF Research Centre, Institute of Clinical Molecular Biology and Tumour Genetics, Marchioninistr 25, D 81377 Munich, Germany
Oncogene 24:520-4. 2005..The data support our current notion that Myc is essential for the regulation of a large number of growth-related genes in B cells, and cannot be replaced by other serum-induced factors...
- Coordinated changes of histone modifications and HDAC mobilization regulate the induction of MHC class II genes by Trichostatin AManolis Gialitakis
Institute of Molecular Biology and Biotechnology, FORTH, Heraklion 71110, Greece
Nucleic Acids Res 34:765-72. 2006..A complex pattern of gene reprogramming by TSA involves immune recognition, antiviral, apoptotic and inflammatory pathways and extends the rationale for using Histone Deacetylase Inhibitors (HDACi) to modulate the immune response...