Katrin Hoffmann

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. doi request reprint Effects of the high-affinity Peptide reversin 121 on multidrug resistance proteins in experimental pancreatic cancer
    Katrin Hoffmann
    Department of General Surgery, Ruprecht Karl University, Heidelberg, Germany
    Tumour Biol 29:351-8. 2008
  2. ncbi request reprint Sorafenib modulates the gene expression of multi-drug resistance mediating ATP-binding cassette proteins in experimental hepatocellular carcinoma
    Katrin Hoffmann
    Department of General and Transplantation Surgery, Ruprecht Karls University, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Anticancer Res 30:4503-8. 2010
  3. pmc Phase III trial of postoperative cisplatin, interferon alpha-2b, and 5-FU combined with external radiation treatment versus 5-FU alone for patients with resected pancreatic adenocarcinoma -- CapRI: study protocol [ISRCTN62866759]
    H P Knaebel
    Department of Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    BMC Cancer 5:37. 2005
  4. pmc Prospective, randomized, double-blind, multi-center, Phase III clinical study on transarterial chemoembolization (TACE) combined with Sorafenib versus TACE plus placebo in patients with hepatocellular cancer before liver transplantation - HeiLivCa [ISRCTN
    K Hoffmann
    Department of Surgery, Ruprecht Karls University, Heidelberg, Germany
    BMC Cancer 8:349. 2008
  5. ncbi request reprint Detection of disseminated pancreatic cells by amplification of cytokeratin-19 with quantitative RT-PCR in blood, bone marrow and peritoneal lavage of pancreatic carcinoma patients
    Katrin Hoffmann
    Department of Visceral, Transplantation, Thoracic and Vascular Surgery, University of Leipzig, Germany
    World J Gastroenterol 13:257-63. 2007
  6. pmc Major combined electrolyte deficiency during therapy with low-dose cisplatin, 5-fluorouracil and interferon alpha: report on several cases and review of the literature [ISRCTN62866759]
    Katrin Hoffmann
    Department of Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    BMC Cancer 6:128. 2006
  7. ncbi request reprint Interferon-alpha restitutes the chemosensitivity in pancreatic cancer
    Katrin Hoffmann
    Department of General Surgery, Ruprecht Karls University of Heidelberg, 69120 Heidelberg, Germany
    Anticancer Res 28:1499-507. 2008
  8. doi request reprint Melatonin protects from hepatic reperfusion injury through inhibition of IKK and JNK pathways and modification of cell proliferation
    Rui Liang
    Department of General Surgery, Ruprecht Karls University, Heidelberg, Germany
    J Pineal Res 46:8-14. 2009
  9. doi request reprint Risk factors of survival after liver transplantation for HCC: a multivariate single-center analysis
    Katrin Hoffmann
    Department of General and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
    Clin Transplant 25:E541-51. 2011
  10. doi request reprint Supplementation of amino acids to prevent reperfusion injury after liver surgery and transplantation--where do we stand today?
    Katrin Hoffmann
    Department of General and Transplantation Surgery, Ruprecht Karls University, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Clin Nutr 30:143-7. 2011

Collaborators

Detail Information

Publications31

  1. doi request reprint Effects of the high-affinity Peptide reversin 121 on multidrug resistance proteins in experimental pancreatic cancer
    Katrin Hoffmann
    Department of General Surgery, Ruprecht Karl University, Heidelberg, Germany
    Tumour Biol 29:351-8. 2008
    ..Multidrug resistance (MDR) is the major obstacle in the treatment of pancreatic carcinoma. Recent studies indicate resistance-modulating effects of high-affinity peptides...
  2. ncbi request reprint Sorafenib modulates the gene expression of multi-drug resistance mediating ATP-binding cassette proteins in experimental hepatocellular carcinoma
    Katrin Hoffmann
    Department of General and Transplantation Surgery, Ruprecht Karls University, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Anticancer Res 30:4503-8. 2010
    ..The aim of this study was to investigate the potential chemosensitizing effects of sorafenib on the multi-drug resistance (MDR) phenotype...
  3. pmc Phase III trial of postoperative cisplatin, interferon alpha-2b, and 5-FU combined with external radiation treatment versus 5-FU alone for patients with resected pancreatic adenocarcinoma -- CapRI: study protocol [ISRCTN62866759]
    H P Knaebel
    Department of Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    BMC Cancer 5:37. 2005
    ..Investigators from the Virginia Mason Clinic have reported a 5-year survival rate of 55% in a phase II trial evaluating adjuvant chemotherapy, immunotherapy and external-beam radiation...
  4. pmc Prospective, randomized, double-blind, multi-center, Phase III clinical study on transarterial chemoembolization (TACE) combined with Sorafenib versus TACE plus placebo in patients with hepatocellular cancer before liver transplantation - HeiLivCa [ISRCTN
    K Hoffmann
    Department of Surgery, Ruprecht Karls University, Heidelberg, Germany
    BMC Cancer 8:349. 2008
    ..The oral multikinase inhibitor sorafenib significantly increases overall survival and time-to-progression in patients with advanced hepatocellular cancer...
  5. ncbi request reprint Detection of disseminated pancreatic cells by amplification of cytokeratin-19 with quantitative RT-PCR in blood, bone marrow and peritoneal lavage of pancreatic carcinoma patients
    Katrin Hoffmann
    Department of Visceral, Transplantation, Thoracic and Vascular Surgery, University of Leipzig, Germany
    World J Gastroenterol 13:257-63. 2007
    ..To evaluate the diagnostic potential of cytokeratin-19 (CK-19) mRNA for the detection of disseminated tumor cells in blood, bone marrow and peritoneal lavage in patients with ductal adenocarcinoma of the pancreas...
  6. pmc Major combined electrolyte deficiency during therapy with low-dose cisplatin, 5-fluorouracil and interferon alpha: report on several cases and review of the literature [ISRCTN62866759]
    Katrin Hoffmann
    Department of Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    BMC Cancer 6:128. 2006
    ..Low-dose Cisplatin and Interferon alpha treatment of solid tumors rarely has been associated with severe hypocalcaemia. To the authors knowledge the phenomenon has not been reported previously in patients with pancreatic carcinoma...
  7. ncbi request reprint Interferon-alpha restitutes the chemosensitivity in pancreatic cancer
    Katrin Hoffmann
    Department of General Surgery, Ruprecht Karls University of Heidelberg, 69120 Heidelberg, Germany
    Anticancer Res 28:1499-507. 2008
    ..Multidrug resistance is a major obstacle in the treatment of pancreatic cancer. Immunochemotherapy including interferon-alpha increases response rates and survival...
  8. doi request reprint Melatonin protects from hepatic reperfusion injury through inhibition of IKK and JNK pathways and modification of cell proliferation
    Rui Liang
    Department of General Surgery, Ruprecht Karls University, Heidelberg, Germany
    J Pineal Res 46:8-14. 2009
    ..At the same time, melatonin reduced the expression of both PCNA and Ki67 in liver (P < 0.05). Melatonin is hepatoprotective most likely via mechanisms including inhibition of IKK and JNK pathways and regulation of cell proliferation...
  9. doi request reprint Risk factors of survival after liver transplantation for HCC: a multivariate single-center analysis
    Katrin Hoffmann
    Department of General and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany
    Clin Transplant 25:E541-51. 2011
    ..Thus, the aim of this study was to determine its impact on tumor progression during waiting time and identify patient subgroups with favorable oncological long-term outcome...
  10. doi request reprint Supplementation of amino acids to prevent reperfusion injury after liver surgery and transplantation--where do we stand today?
    Katrin Hoffmann
    Department of General and Transplantation Surgery, Ruprecht Karls University, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Clin Nutr 30:143-7. 2011
    ..Aim of this review was to summarize the evidence for prevention of IRI by amino acid supplement and to give an overview on potential clinical use in liver surgery...
  11. ncbi request reprint Factors Predictive of Survival After Stapler Hepatectomy of Hepatocellular Carcinoma: A Multivariate, Single-center Analysis
    Katrin Hoffmann
    Department of General and Transplant Surgery, University Hospital of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Anticancer Res 34:767-76. 2014
    ..New technical devices for hepatic parenchymal transection have improved perioperative safety and patient survival. The aim of the present study was to determine the oncological outcome after stapler hepatectomy in patients with HCC...
  12. doi request reprint Open-label, multicenter, randomized phase III trial of adjuvant chemoradiation plus interferon Alfa-2b versus fluorouracil and folinic acid for patients with resected pancreatic adenocarcinoma
    Jan Schmidt
    Department of Surgery, Ruprecht Karls University, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    J Clin Oncol 30:4077-83. 2012
    ..Adjuvant chemotherapy prolongs survival in patients with pancreatic cancer, but its benefit is limited. Long-term survival times of up to 44 months after adjuvant chemoradioimmunotherapy in phase II trials motivated the present study...
  13. pmc Involvement of the epidermal growth factor receptor in the modulation of multidrug resistance in human hepatocellular carcinoma cells in vitro
    Katrin Hoffmann
    Department of General and Transplantation Surgery, Ruprecht Karls University, Heidelberg, Germany
    Cancer Cell Int 11:40. 2011
    ..abstract:..
  14. doi request reprint Dietary glycine protects from chemotherapy-induced hepatotoxicity
    Saulius Mikalauskas
    Department of General and Transplantation Surgery, Ruprecht Karls University of Heidelberg, Heidelberg, Germany
    Amino Acids 40:1139-50. 2011
    ..05). This study shows for the first time that glycine reduces chemotherapy-induced liver injury. The underlying mechanisms most likely include Kupffer cells and an improved intrahepatic microperfusion...
  15. doi request reprint Sulforaphane protects hearts from early injury after experimental transplantation
    Zhanqing Li
    Department of General and Transplant Surgery, Ruprecht Karls University, Heidelberg, Germany
    Ann Transplant 18:558-66. 2013
    ..The aim of this study was to ameliorate IRI following heart transplants by recipient preconditioning...
  16. ncbi request reprint Correlation of gene expression of ATP-binding cassette protein and tyrosine kinase signaling pathway in patients with hepatocellular carcinoma
    Katrin Hoffmann
    Department of General and Transplantation Surgery, Ruprecht Karls University, Im Neuenheimer Feld 110, D 69120 Heidelberg, Germany
    Anticancer Res 31:3883-90. 2011
    ..The aim of our study was to determine the relevance of kinase and multidrug-resistance protein expression in human hepatocellular carcinoma (HCC)...
  17. doi request reprint Liver resection for multimodal treatment of breast cancer metastases: identification of prognostic factors
    Katrin Hoffmann
    Department of General and Transplantation Surgery, Ruprecht Karls University of Heidelberg, Heidelberg, Germany
    Ann Surg Oncol 17:1546-54. 2010
    ..The aim of this study was to evaluate the outcome of LR in patients with hepatic breast cancer metastases...
  18. doi request reprint Modified body mass index and time interval between diagnosis and operation affect survival after liver transplantation for hereditary amyloidosis: a single-center analysis
    Clemens Franz
    Department of General and Transplant Surgery, Ruprecht Karls University Heidelberg, Heidelberg, Germany
    Clin Transplant 27:40-8. 2013
    ..As the mutated amyloid protein is mainly produced in the liver, one form of treatment to halt the progression of disease is liver transplantation (LT). This study was performed to identify risk factors for decreased overall survival...
  19. pmc MEK inhibition induced downregulation of MRP1 and MRP3 expression in experimental hepatocellular carcinoma
    Shibo Lin
    Department of General and Transplant Surgery, Ruprecht Karls University, Im Neuenheimer Feld 110, Heidelberg, 69120, Germany
    Cancer Cell Int 13:3. 2013
    ..abstract:..
  20. doi request reprint Methylome analysis and integrative profiling of human HCCs identify novel protumorigenic factors
    Olaf Neumann
    Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany
    Hepatology 56:1817-27. 2012
    ..Additionally, functional analysis supported a tumor-suppressive function for PER3 and IGFALS in vitro...
  21. doi request reprint Is veno-venous bypass still needed during liver transplantation? A review of the literature
    Katrin Hoffmann
    Department of General Surgery, Ruprecht Karls University, Heidelberg, Germany
    Clin Transplant 23:1-8. 2009
    ..The latter, recent developments of cava-sparing surgical techniques, shorter anhepatic times plus optimized anesthetic management have made the necessity for a routine use of VVB questionable...
  22. ncbi request reprint Stroke MRI in intracerebral hemorrhage: is there a perihemorrhagic penumbra?
    Peter D Schellinger
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 34:1674-9. 2003
    ..We sought to assess the presence and prognostic effect of perihemorrhagic ischemic changes and hypoperfusion in a prospective stroke MRI study...
  23. ncbi request reprint Efficacy and nontarget effects of transarterial chemoembolization in bridging of hepatocellular carcinoma patients to liver transplantation: a histopathologic study
    Ulrike Stampfl
    Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany Electronic address
    J Vasc Interv Radiol 25:1018-1026.e4. 2014
    ..To histologically evaluate the efficacy and nontarget effects induced by transarterial chemoembolization as a "bridge" treatment of hepatocellular carcinoma (HCC) before liver transplantation (LT) and its relation to patient survival...
  24. doi request reprint Sorafenib treatment is save and may affect survival of recurrent hepatocellular carcinoma after liver transplantation
    Jan Pfeiffenberger
    Department of Gastroenterology and Hepatology, University Hospital Heidelberg, Heidelberg, INF 410, 69120, Heidelberg, Germany
    Langenbecks Arch Surg 398:1123-8. 2013
    ..Because of a plethora of possible drug interactions, e.g., with immunosuppressant or anti-infective therapy, safety and feasibility of sorafenib treatment requires special attention...
  25. ncbi request reprint Melatonin protects kidney grafts from ischemia/reperfusion injury through inhibition of NF-kB and apoptosis after experimental kidney transplantation
    Zhanqing Li
    Department of General Surgery, Ruprecht Karls University, Heidelberg, Germany
    J Pineal Res 46:365-72. 2009
    ..In conclusion, donor preconditioning with melatonin protected kidney donor grafts from IRI-induced renal dysfunction and tubular injury most likely through its anti-oxidative, anti-apoptotic and NF-kB inhibitory capacity...
  26. doi request reprint Prediction of relapse in paediatric pre-B acute lymphoblastic leukaemia using a three-gene risk index
    Katrin Hoffmann
    Division of Children s Leukaemia and Cancer Research, Telethon Institute for Child Health Research, Centre for Child Health Research, Unviersity of Western Australia, Perth, WA, Australia
    Br J Haematol 140:656-64. 2008
    ..This is particularly important for the identification of patients destined to relapse despite their current stratification as SR, as more intensive front-line treatment options for these individuals are already available...
  27. ncbi request reprint Identification of novel molecular prognostic markers for paediatric T-cell acute lymphoblastic leukaemia
    Nicholas G Gottardo
    Division of Children s Leukaemia and Cancer Research, Telethon Institute for Child Health Research and Centre for Child Health Research, University of Western Australia, Perth, WA, Australia
    Br J Haematol 137:319-28. 2007
    ..The independent influence of the 3-gene predictor was confirmed by multivariate analysis. Our study provides proof of principle that genome-wide expression profiling can detect novel molecular prognostic markers in paediatric T-ALL...
  28. pmc Translating microarray data for diagnostic testing in childhood leukaemia
    Katrin Hoffmann
    Division of Children s Leukaemia and Cancer Research, Telethon Institute for Child Health Research and Centre for Child Health Research, The University of Western Australia, Perth, Australia
    BMC Cancer 6:229. 2006
    ..As a step towards clinical application of these findings, we have systematically analyzed a published ALL microarray data set using Robust Multi-array Analysis (RMA) and Random Forest (RF)...
  29. ncbi request reprint The gene expression signature of relapse in paediatric acute lymphoblastic leukaemia: implications for mechanisms of therapy failure
    Alex H Beesley
    Division of Children s Leukaemia and Cancer Research, Telethon Institute for Child Health Research, University of Western Australia, Perth, WA, Australia
    Br J Haematol 131:447-56. 2005
    ..Our results provide evidence for a link between drug resistance and the microenvironment that has previously only been considered in the context of solid tumour biology...
  30. pmc Gene expression levels assessed by oligonucleotide microarray analysis and quantitative real-time RT-PCR -- how well do they correlate?
    Peter B Dallas
    Division of Children s Leukaemia and Cancer Research, Telethon Institute for Child Health Research and Centre for Child Health Research, The University of Western Australia, Perth, Australia
    BMC Genomics 6:59. 2005
    ..We have assessed the correlation between expression scores obtained for 48 human genes using oligonucleotide microarrays and the expression levels for the same genes measured by quantitative real-time RT-PCR (qRT-PCR)...
  31. ncbi request reprint Gene expression levels in small specimens from patients detected using oligonucleotide arrays
    Katrin Hoffmann
    Division of Children s Leukaemia and Cancer Research, Telethon Institute for Child Health Research, P O Box 855, West Perth WA 6872, Australia
    Mol Biotechnol 29:31-8. 2005
    ..Most importantly, there was no statistically significant difference when the concordance percentages for low abundance genes were compared, demonstrating that as little as 2 microg of total RNA is sufficient to perform GeneChip analysis...