H Hof

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. doi request reprint Gliotoxin in Aspergillus fumigatus: an example that mycotoxins are potential virulence factors
    Herbert Hof
    Institute of Medical Microbiology and Hygiene, University Clinic Mannheim, University of Heidelberg, Theodor, Kutzer Ufer, 68167, Mannheim, Germany
    Mycotoxin Res 25:123-31. 2009
  2. doi request reprint Antifungal activity of anidulafungin, a product of Aspergillus nidulans, against Aspergillus nidulans
    H Hof
    Institute of Medical Microbiology and Hygiene, University Clinic Mannheim, University of Heidelberg, Mannheim, Germany
    Int J Antimicrob Agents 33:285-6. 2009
  3. doi request reprint [Medical relevance of mycotoxins]
    H Hof
    Institut fur Medizin, Mikrobiologie und Hygiene, Universitatsklinikum Mannheim, Mannheim
    Dtsch Med Wochenschr 133:1084-8. 2008
  4. doi request reprint Is there a serious risk of resistance development to azoles among fungi due to the widespread use and long-term application of azole antifungals in medicine?
    Herbert Hof
    Institute of Medical Microbiology and Hygiene, University Clinic Mannheim, University of Heidelberg, D 68167 Mannheim, Germany
    Drug Resist Updat 11:25-31. 2008
  5. ncbi request reprint History and epidemiology of listeriosis
    H Hof
    Institute of Medical Microbiology and Hygiene, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Theodor Kutzer Ufer, 68167 Mannheim, Germany
    FEMS Immunol Med Microbiol 35:199-202. 2003
  6. ncbi request reprint Listeriosis: therapeutic options
    Herbert Hof
    Institute of Medical Microbiology and Hygiene, Faculty of Clinical Medicine, Mannheim, Heidelberg University, D 68167 Mannheim, Germany
    FEMS Immunol Med Microbiol 35:203-5. 2003
  7. ncbi request reprint [Candida, aspergillus and company. Pathogenic fungi]
    Herbert Hof
    Universitätsklinikum Mannheim Institut für Medizinische Mikrobiologie und Hygiene, 68135 Mannheim
    Pharm Unserer Zeit 32:96-103. 2003
  8. ncbi request reprint Mycotoxins: pathogenicity factors or virulence factors?
    Herbert Hof
    Institute of Medical Microbiology and Hygiene, University Clinic Mannheim, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany
    Mycoses 51:93-4. 2008
  9. doi request reprint Will resistance in fungi emerge on a scale similar to that seen in bacteria?
    H Hof
    Institute of Medical Microbiology and Hygiene, University Clinic Mannheim, University of Heidelberg, 68167 Mannheim, Germany
    Eur J Clin Microbiol Infect Dis 27:327-34. 2008
  10. ncbi request reprint An update on the medical management of listeriosis
    Herbert Hof
    Heidelberg University, Institute of Medical Microbiology and Hygiene, Faculty of Clinical Medicine Mannheim, D 68167 Mannheim, Germany
    Expert Opin Pharmacother 5:1727-35. 2004

Collaborators

Detail Information

Publications60

  1. doi request reprint Gliotoxin in Aspergillus fumigatus: an example that mycotoxins are potential virulence factors
    Herbert Hof
    Institute of Medical Microbiology and Hygiene, University Clinic Mannheim, University of Heidelberg, Theodor, Kutzer Ufer, 68167, Mannheim, Germany
    Mycotoxin Res 25:123-31. 2009
    ..Mycotoxins have also been shown to act as virulence factors in some fungal infections of insects and plants...
  2. doi request reprint Antifungal activity of anidulafungin, a product of Aspergillus nidulans, against Aspergillus nidulans
    H Hof
    Institute of Medical Microbiology and Hygiene, University Clinic Mannheim, University of Heidelberg, Mannheim, Germany
    Int J Antimicrob Agents 33:285-6. 2009
    ..031mg/L. The presence of serum did not affect the in vitro activity. In conclusion, chemical modification of the original echinocandin B moiety renders this natural product active against moulds, including A. nidulans...
  3. doi request reprint [Medical relevance of mycotoxins]
    H Hof
    Institut fur Medizin, Mikrobiologie und Hygiene, Universitatsklinikum Mannheim, Mannheim
    Dtsch Med Wochenschr 133:1084-8. 2008
    ..However, the relevance of mycotoxins in human medicine remains largely underestimated, because material from patients with characteristic symptoms is rarely tested for mycotoxins...
  4. doi request reprint Is there a serious risk of resistance development to azoles among fungi due to the widespread use and long-term application of azole antifungals in medicine?
    Herbert Hof
    Institute of Medical Microbiology and Hygiene, University Clinic Mannheim, University of Heidelberg, D 68167 Mannheim, Germany
    Drug Resist Updat 11:25-31. 2008
    ..Indeed, in epidemiologic studies on human and environmental isolates there is convincing evidence that azole resistance is quite uncommon...
  5. ncbi request reprint History and epidemiology of listeriosis
    H Hof
    Institute of Medical Microbiology and Hygiene, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Theodor Kutzer Ufer, 68167 Mannheim, Germany
    FEMS Immunol Med Microbiol 35:199-202. 2003
    ..the role in immunology: basic knowledge on cell-mediated immunity has been acquired through the model of listeriosis. This paper presents information on the past and the actual situation in research on Listeria and listeriosis...
  6. ncbi request reprint Listeriosis: therapeutic options
    Herbert Hof
    Institute of Medical Microbiology and Hygiene, Faculty of Clinical Medicine, Mannheim, Heidelberg University, D 68167 Mannheim, Germany
    FEMS Immunol Med Microbiol 35:203-5. 2003
    ..Few agents, such as macrolides and quinolones, are accumulated within host cells and may attack the intracellular Listeriae. The clinical experience shows that the combination of amoxicillin and gentamicin is the best option...
  7. ncbi request reprint [Candida, aspergillus and company. Pathogenic fungi]
    Herbert Hof
    Universitätsklinikum Mannheim Institut für Medizinische Mikrobiologie und Hygiene, 68135 Mannheim
    Pharm Unserer Zeit 32:96-103. 2003
  8. ncbi request reprint Mycotoxins: pathogenicity factors or virulence factors?
    Herbert Hof
    Institute of Medical Microbiology and Hygiene, University Clinic Mannheim, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany
    Mycoses 51:93-4. 2008
  9. doi request reprint Will resistance in fungi emerge on a scale similar to that seen in bacteria?
    H Hof
    Institute of Medical Microbiology and Hygiene, University Clinic Mannheim, University of Heidelberg, 68167 Mannheim, Germany
    Eur J Clin Microbiol Infect Dis 27:327-34. 2008
    ..Therefore, the likelihood for an explosion of fungal resistance is relatively low...
  10. ncbi request reprint An update on the medical management of listeriosis
    Herbert Hof
    Heidelberg University, Institute of Medical Microbiology and Hygiene, Faculty of Clinical Medicine Mannheim, D 68167 Mannheim, Germany
    Expert Opin Pharmacother 5:1727-35. 2004
    ..Adjunctive therapy with immunomodulators, which are able to reconstitute the defective defence capacities, would presumably create the conditions necessary to finally resolve listeriosis...
  11. ncbi request reprint [Epidemiology of listeriosis in Germany: a changing but ignored pattern]
    H Hof
    Institut fur Medizinische Mikrobiologie und Hygiene, Universitatsklinikum Mannheim, Universitat Heidelberg, Mannheim, Germany
    Dtsch Med Wochenschr 132:1343-8. 2007
    ..Furthermore, even within the food isolates there is a large diversity of clones. A comprehensive explanation for the changes in the epidemiology of human listeriosis has yet to be given...
  12. ncbi request reprint A new, broad-spectrum azole antifungal: posaconazole--mechanisms of action and resistance, spectrum of activity
    H Hof
    Institute for Medical Microbiology and Hygiene, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    Mycoses 49:2-6. 2006
    ..There are several methods to test the in vitro activities of posaconazole including the E-test, though interpretive breakpoints are still lacking...
  13. ncbi request reprint Listeria monocytogenes: a causative agent of gastroenteritis?
    H Hof
    Institute for Medical Microbiology and Hygiene, University of Heidelberg, Mannheim, Germany
    Eur J Clin Microbiol Infect Dis 20:369-73. 2001
    ..Although Listeria monocytogenes is undoubtedly a potential enteric pathogen, it is still debatable whether its detection in a routine bacteriological examination of a stool specimen is of clinical significance...
  14. ncbi request reprint Enhancement of the Listeria monocytogenes p60-specific CD4 and CD8 T cell memory by nonpathogenic Listeria innocua
    G Geginat
    Institut fur Medizinische Mikrobiologie und Hygiene, Fakultät für Klinische Medizin Mannheim der Universität Heidelberg, Mannheim, Germany
    J Immunol 162:4781-9. 1999
    ..innocua, which is nonpathogenic and not adapted to intracellular replication, can contribute to the maintenance of memory T cells specific for a related intracellular pathogen...
  15. ncbi request reprint A novel approach of direct ex vivo epitope mapping identifies dominant and subdominant CD4 and CD8 T cell epitopes from Listeria monocytogenes
    G Geginat
    Institut fur Medizinische Mikrobiologie und Hygiene, Fakultät für Klinische Medizin Mannheim der Universität Heidelberg, Mannheim, Germany
    J Immunol 166:1877-84. 2001
    ....
  16. ncbi request reprint Th1 cells specific for a secreted protein of Listeria monocytogenes are protective in vivo
    G Geginat
    Institut fur Medizinische Mikrobiologie und Hygiene, Fakultät für Klinische Medizin Mannheim der Universität Heidelberg, Mannheim, Germany
    J Immunol 160:6046-55. 1998
    ..monocytogenes...
  17. pmc Influence of liposomal amphotericin B on CD8 T-cell function
    M Kretschmar
    , , 68167 Mannheim, Germany
    Antimicrob Agents Chemother 45:2383-5. 2001
    ....
  18. ncbi request reprint Gliotoxin-mediated suppression of innate and adaptive immune functions directed against Listeria monocytogenes
    C Kupfahl
    Institut fur Medizinische Mikrobiologie und Hygiene, Fakultät für Klinische Medizin Mannheim der Universität Heidelberg, Theodor Kutzer Ufer 1 3, 68167, Mannheim, Germany
    Med Mycol 44:591-9. 2006
    ..monocytogenes infection. Taken together, these results demonstrate the suppressive effects of gliotoxin on the innate and also on the adaptive T cell-mediated antilisterial immunity...
  19. ncbi request reprint Immune reactions to Listeria monocytogenes in the brain
    D Schluter
    Institut für Med Mikrobiologie und Hygiene, Universitat Heidelberg, Universitatsklinikum Mannheim, Germany
    Immunobiology 201:188-95. 1999
    ..The favorable prognosis of immunized mice correlated with a reduced intracerebral bacterial load, an increased recruitment of protective CD4+ and CD8+ T cells as well as an upregulated mRNA production of protective cytokines...
  20. ncbi request reprint Efficient treatment of murine systemic infection with Candida albicans using amphotericin B incorporated in nanosize range particles (emulsomes)
    M Kretschmar
    Institute of Medical Microbiology and Hygiene, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Germany
    Mycoses 44:281-6. 2001
    ..Therefore, in our models, the incorporation of AmB into nanosize particles was able to reduce toxicity without loss of efficiency. EAmB may be considered a candidate preparation for the treatment of infections with C. albicans in humans...
  21. ncbi request reprint Fungicidal effect of tyrothricin on Candida albicans
    M Kretschmar
    Institute of Medical Microbiology and Hygiene, Faculty of Clinical Medicine, Mannheim, Germany
    Mycoses 39:45-50. 1996
    ..Because fungicidal concentrations of tyrothricin are locally achievable in patients, an evaluation of the local effect of tyrothricin in patients suffering from mucosal infections with Candida species should be considered...
  22. doi request reprint Developments in the epidemiolgy of invasive fungal infections - implications for the empiric and targeted antifungal therapy
    H Hof
    Institute for Medical Microbiology and Hygiene, University Clinic Mannheim, University of Heidelberg, Theodor Kutzer Ufer, Mannheim, Germany
    Mycoses 51:1-6. 2008
    ..Once the diagnosis is completed and a susceptibility pattern of the causative agent is available, a targeted therapy can be given respecting pharmacology, side effects and interactions with co-administered drugs...
  23. ncbi request reprint Dynamic antigen presentation patterns of Listeria monocytogenes-derived CD8 T cell epitopes in vivo
    M Skoberne
    , , Mannheim, Germany
    J Immunol 167:2209-18. 2001
    ..In summary, our studies show that Ag presentation during an infection is a highly dynamic process that only can be fully appreciated by the study of cells infected in their physiological environment...
  24. ncbi request reprint Systemic and intracerebral infections of mice with Listeria monocytogenes successfully treated with linezolid
    M Callapina
    Institute of Medical Microbiology and Hygiene, Faculty of Clinical Medicine, University of Heidelberg, Mannheim, Germany
    J Chemother 13:265-9. 2001
    ..In conclusion, linezolid might be useful for the treatment of infections with L monocytogenes in humans when ampicillin may not be used...
  25. ncbi request reprint Successful treatment of murine listeriosis and salmonellosis with levofloxacin
    T Nichterlein
    Institute of Medical Microbiology and Hygiene Mannheim, Faculty of Clinical Medicine, University of Heidelberg, Germany
    J Chemother 10:313-9. 1998
    ..In conclusion, levofloxacin is a candidate for the treatment of infections caused by facultative intracellular Gram-positive and Gram-negative bacteria...
  26. pmc Phosphatidylcholine-specific phospholipase C from Listeria monocytogenes is an important virulence factor in murine cerebral listeriosis
    D Schluter
    Institut fur Medizinische Mikrobiologie und Hygiene, Universit atsklinikum Mannheim, Universitat Heidelberg, Mannheim, Germany
    Infect Immun 66:5930-8. 1998
    ..In conclusion, this study points to PlcB as a virulence factor important for the intracerebral pathogenesis of murine L. monocytogenes meningoencephalitis...
  27. ncbi request reprint RP 59500, a streptogramin derivative, is effective in murine listeriosis
    T Nichterlein
    Institute of Medical Microbiology and Hygiene, University of Heidelberg, 68135 Mannheim, Germany
    J Chemother 8:107-12. 1996
    ..We conclude that RP 59500 is a candidate substance for the treatment of human listeriosis which might be used when therapy with ampicillin is not feasible...
  28. doi request reprint Breakpoints for posaconazole susceptibility testing: background and discussion about the need of establishing values
    R Fleck
    Faculty of Medicine Mannheim, Institute of Medical Microbiology and Hygiene, University of Heidelberg, Heidelberg, Germany
    Mycoses 51:1-4. 2008
    ..From the practical point of view, it is therefore important not only to establish breakpoints for the reference method but also for the inexpensive and easy to perform testing methods, which are suitable for smaller laboratories...
  29. ncbi request reprint Regulation of microglia by CD4+ and CD8+ T cells: selective analysis in CD45-congenic normal and Toxoplasma gondii-infected bone marrow chimeras
    D Schluter
    Institut für Med Mikrobiologie und Hygiene, Universität sklinikum Mannheim, Universitat Heidelberg, Germany
    Brain Pathol 11:44-55. 2001
    ..These findings demonstrate a specific regulation of microglia by T lymphocytes during the course of TE...
  30. ncbi request reprint Parameters for determination of Candida albicans virulence in murine peritonitis
    M Kretschmar
    Institut fur Medizinische Mikrobiologie und Hygiene, Klinikum Mannheim, Germany
    Mycoses 42:19-24. 1999
    ..albicans to invade neighbouring organs, to reach the brain upon dissemination and germination in the brain and kidneys may be used for measurement of virulence in this model when virulence is defined as lethality...
  31. ncbi request reprint Erythromycin is ineffective against Listeria monocytogenes in multidrug resistant cells
    T Nichterlein
    Institute of Medical Microbiology and Hygiene, University of Heidelberg, Mannheim, Germany
    J Chemother 7:184-8. 1995
    ....
  32. ncbi request reprint Effects of FK-506 on the course of murine salmonellosis
    T Nichterlein
    Institute of Medical Microbiology and Hygiene, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany
    J Chemother 8:449-56. 1996
    ..We conclude that both substances aggravate murine salmonellosis, most likely by inhibition of T-cell function. Patients receiving FK-506 might also be, therefore, at risk of salmonella infection...
  33. ncbi request reprint Adjuvant treatment of brain metastases
    F Lohr
    Department of Clinical Radiology, University of Heidelberg, Heidelberg, Germany frank
    Semin Surg Oncol 20:50-6. 2001
    ..However, RS is definitely an excellent option for salvage and palliation in patients with short life expectancy, as it is simultaneously noninvasive and cost-effective, with short hospitalization times...
  34. ncbi request reprint [Stereotactic irradiation of lung tumors]
    H Hof
    Abteilung Klinische Radiologie, Universitatsklinikum Heidelberg
    Radiologe 44:484-90. 2004
    ..But also the utilization for the therapy of lung metastases of solid tumors is possible. In spite of small patient cohorts and limited long-term data compared to conventional radiotherapy the results are promising...
  35. ncbi request reprint [Treatment of metastases--the place of radiotherapy]
    H Hof
    Abt Radioonkologie, Universitat Heidelberg
    MMW Fortschr Med 147:31-3. 2005
    ..Similar techniques of precision irradiation are now also being applied to visceral metastases. Impressive remission rates have been achieved in the lungs and liver...
  36. doi request reprint Change of aesthetic and functional outcome over time and their relationship to quality of life after breast conserving therapy
    J Heil
    Breast Unit, University of Heidelberg, Vossstrasse 9, 69115 Heidelberg, Germany
    Eur J Surg Oncol 37:116-21. 2011
    ..Our special interest resides in the question of whether these aspects gain or loose their influence on quality of life (QoL) with temporal progress...
  37. ncbi request reprint Diagnostic yield of bronchoscopy with bronchoalveolar lavage in febrile patients with hematologic malignancies and pulmonary infiltrates
    Margit Hummel
    3 Medizinische Klinik, Universitatsklinikum Mannheim, University of Heidelberg, Mannheim, Germany
    Ann Hematol 87:291-7. 2008
    ....
  38. ncbi request reprint Gliotoxin production by clinical and environmental Aspergillus fumigatus strains
    Claudio Kupfahl
    Faculty for Clinical Medicine Mannheim, University of Heidelberg, Institute for Medical Microbiology and Hygiene, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    Int J Med Microbiol 298:319-27. 2008
    ..In contrast, lack of gliotoxin production in the other Aspergillus species tested had no significant influence on the cytotoxic effect of culture supernatant on these immune cells...
  39. ncbi request reprint Candida species fail to produce the immunosuppressive secondary metabolite gliotoxin in vitro
    Claudio Kupfahl
    Institute for Medical Microbiology and Hygiene, Faculty for Clinical Medicine Mannheim of the University Heidelberg, Mannheim, Germany
    FEMS Yeast Res 7:986-92. 2007
    ..Therefore, in contrast to previous studies, our data strongly suggest that at least the Candida species investigated in this study are not able to produce the secondary metabolite gliotoxin...
  40. ncbi request reprint In vitro susceptibility of Candida species to five antifungal agents in a German university hospital assessed by the reference broth microdilution method and Etest
    Ralf Fleck
    Institute of Medical Microbiology and Hygiene, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Germany
    J Antimicrob Chemother 59:767-71. 2007
    ..Since quick results of in vitro testing are desirable, Etest and the CLSI broth microdilution (BMD) method (reference method) were compared, focusing on the validity of early readings...
  41. ncbi request reprint Water birth: microbiological colonisation of the newborn, neonatal and maternal infection rate in comparison to conventional bed deliveries
    Patricia Fehervary
    Universitätsfrauenklinik Mannheim, Klinische Fakultät, Universitat Heidelberg, Mannheim, Germany
    Arch Gynecol Obstet 270:6-9. 2004
    ..The risk of infectious complications after water birth which might be due to water contaminated by faecal bacteria or environmental microbes from the water supply system is still in discussion...
  42. ncbi request reprint Deletion of the gliP gene of Aspergillus fumigatus results in loss of gliotoxin production but has no effect on virulence of the fungus in a low-dose mouse infection model
    Claudio Kupfahl
    Institute for Medical Microbiology and Hygiene, Faculty for Clinical Medicine Mannheim of the University Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Mol Microbiol 62:292-302. 2006
    ..fumigatus. Gliotoxin is not required for pathogenicity of the fungus in immunocompromised mice, despite the fact that a reduced cytotoxicity of the culture supernatant of gliP deletion strains was demonstrated...
  43. ncbi request reprint Galactomannan enzyme immunoassay for monitoring systemic infection with Aspergillus fumigatus in mice
    M Kretschmar
    , Klinikum Mannheim, D-68135, Mannheim, Germany
    Diagn Microbiol Infect Dis 41:107-12. 2001
    ..Therefore, the test was excellent for detection of early i.v. infection with Aspergillus fumigatus but not suited for detection of limited organ infection in immunocompetent mice...
  44. pmc Toxoplasma gondii infection of neurons induces neuronal cytokine and chemokine production, but gamma interferon- and tumor necrosis factor-stimulated neurons fail to inhibit the invasion and growth of T. gondii
    D Schluter
    Institut fur Medizinische Mikrobiologie und Hygiene, Universitatsklinikum Mannheim, Universitat Heidelberg, Mannheim, Germany
    Infect Immun 69:7889-93. 2001
    ..Neuronal expression of some cytokines (IL-6, TGF-beta1) and chemokines (MIP-1beta) was regulated by infection and/or by IFN-gamma and TNF...
  45. doi request reprint Modulation of innate and antigen-specific immune functions directed against Listeria monocytogenes by fungal toxins in vitro
    I Herter
    Institute for Medical Microbiology and Hygiene, Medical Faculty Mannheim of the University Heidelberg, Theodor Kutzer Ufer 1 3, 68167, Mannheim, Germany
    Mycotoxin Res 30:79-87. 2014
    ..Thus, our results enhance the understanding of role of mycotoxins in the pathogenesis of human and animal diseases. ..
  46. ncbi request reprint Individual acid aspartic proteinases (Saps) 1-6 of Candida albicans are not essential for invasion and colonization of the gastrointestinal tract in mice
    Marianne Kretschmar
    Institut fur Medizinische Mikrobiologie und Hygiene, Fakultät für Klinische Medizin Mannheim der Universität Heidelberg, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    Microb Pathog 32:61-70. 2002
    ..We conclude that although Saps were produced, individual Saps were not indispensable factors for virulence during gastrointestinal infection of mice...
  47. ncbi request reprint Lentinan has a stimulatory effect on innate and adaptive immunity against murine Listeria monocytogenes infection
    C Kupfahl
    Institut fur Medizinische Mikrobiologie und Hygiene, Fakultät für Klinische Medizin Mannheim der Universität Heidelberg, Germany
    Int Immunopharmacol 6:686-96. 2006
    ..In summary these results show that lentinan enhances the protective CD8 T-cell response against L. monocytogenes probably by a mechanism that involves the IL-12-mediated augmentation of the specific antilisterial CD8 T-cell response...
  48. ncbi request reprint Trichosporon asahii infection of a dialysis PTFE arteriovenous graft
    S Krzossok
    Vth Department of Medicine Nephrology Endocrinology Rheumatology, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
    Clin Nephrol 62:66-8. 2004
    ..Here, we report on a Trichosporon infection of an arteriovenous graft in a patient on chronic hemodialysis. The infection was successfully treated with fluconazole and total surgical resection of the graft...
  49. doi request reprint Diagnostic yield of blood cultures from antibiotic-naïve and antibiotically treated patients with haematological malignancies and high-risk neutropenia
    Margit Hummel
    III Medizinische Universitätsklinik, Medizinische Fakultat Mannheim, Universitat Heidelberg, Mannheim, Germany
    Scand J Infect Dis 41:650-5. 2009
    ..The epidemiological data obtained are helpful for selecting empirical antibiotic treatment regimens...
  50. ncbi request reprint Cross-presentation of Listeria monocytogenes-derived CD4 T cell epitopes
    Mojca Skoberne
    Institut fur Medizinische Mikrobiologie und Hygiene, Fakultät für Klinische Medizin Mannheim der Universität Heidelberg, Mannheim, Germany
    J Immunol 169:1410-8. 2002
    ....
  51. ncbi request reprint Molecular characterization of the genes encoding DNA gyrase and topoisomerase IV of Listeria monocytogenes
    Robert Lampidis
    Institute of Medical Microbiology and Hygiene, Faculty of Clinical Medicine Mannheim, University of Heidelberg, D 68167 Mannheim, Germany
    J Antimicrob Chemother 49:917-24. 2002
    ..monocytogenes. However, these heterodiploid strains were not affected in their resistance to nalidixic acid. The effects of the mutant plasmids on ciprofloxacin and sparfloxacin susceptibility were only modest...
  52. doi request reprint Pneumocystis jiroveci pneumonia in a patient with Wegener's granulomatosis treated efficiently with caspofungin
    Herbert Hof
    Institute for Microbiology and Hygiene, University Hospital Mannheim, Medical Faculty Mannheim of the University of Heidelberg, Germany
    Mycoses 51:65-7. 2008
    ..The patient's complaints subsequently resolved within days after initiation of treatment. Tolerability of the drug was excellent. No relapse occurred during the ongoing 4 years, although immunosuppressive therapy continued...
  53. ncbi request reprint Functional analysis of a vacuolar ABC transporter in wild-type Candida albicans reveals its involvement in virulence
    Stephanie Theiss
    Zentrum für Infektionsforschung, Universitat Wurzburg, D 97070 Wurzburg, Germany
    Mol Microbiol 43:571-84. 2002
    ..Hence, this report provides primary evidence for the involvement of vacuolar ABC transporters in fungal virulence...
  54. pmc Rapid identification and typing of listeria species by matrix-assisted laser desorption ionization-time of flight mass spectrometry
    Sukhadeo B Barbuddhe
    Institute of Medical Microbiology, Justus Liebig University, Frankfurter Strasse 107, D 35392 Giessen, Germany
    Appl Environ Microbiol 74:5402-7. 2008
    ..MALDI-TOF MS fingerprinting may have potential for Listeria identification and subtyping and may improve infection control measures...
  55. pmc Transcriptional regulators Cph1p and Efg1p mediate activation of the Candida albicans virulence gene SAP5 during infection
    Peter Staib
    Zentrum für Infektionsforschung Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, Rontgenring 11, D 97070 Wurzburg, Germany
    Infect Immun 70:921-7. 2002
    ..The avirulence of the cph1 efg1 mutant seemed to be caused not only by the inability to form hyphae but also by a loss of expression of additional virulence genes in the host...
  56. ncbi request reprint Host versus in vitro signals and intrastrain allelic differences in the expression of a Candida albicans virulence gene
    Peter Staib
    Zentrum für Infektionsforschung, Universitat Wurzburg, D 97020 Würzburg, Germany
    Mol Microbiol 44:1351-66. 2002
    ..albicans seems to use its diploid genome to create further variability and host adaptation by differential evolution of even the two alleles of a single gene...
  57. ncbi request reprint [Oral candidiasis]
    Dieter Reinel
    Bundeswehrkrankenhaus Hamburg, Abt f Dermatologie, Venerologie und Allergologie
    J Dtsch Dermatol Ges 2:874-6. 2004
  58. ncbi request reprint [Tinea capitis]
    Claus Seebacher
    J Dtsch Dermatol Ges 2:462-8. 2004
  59. ncbi request reprint Onychomycosis
    Claus Seebacher
    Dresden, Germany
    J Dtsch Dermatol Ges 5:61-6. 2007
  60. ncbi request reprint Tinea capitis
    Claus Seebacher
    J Dtsch Dermatol Ges 4:1085-91. 2006