Research Topics
| A HoeraufSummaryAffiliation: University of Bonn Country: Germany Publications
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Detail Information
Publications
T regulatory-1 cells induce IgG4 production by B cells: role of IL-10Judith S Satoguina
Institute of Medical Parasitology, Friedrich Wilhelm University of Bonn, Bonn, Germany
J Immunol 174:4718-26. 2005..The correlation between IgG4 and IL-10 (r2 = 0.352) indicates that IL-10 is an important but not the only factor for IgG4 induction...- New strategies to combat filariasisAchim Hoerauf
Institute of Medical Microbiology, Immunology and Parasitology, University Clinic Bonn, 53105 Bonn, Germany
Expert Rev Anti Infect Ther 4:211-22. 2006.... 
Onchocerciasis Control: Vision for the Future from a Ghanian perspectiveMark J Taylor
Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Liverpool, UK
Parasit Vectors 2:7. 2009....- Cloning, expression and functional activity of deoxyhypusine synthase from Plasmodium vivaxJames T Njuguna
Institute for Medical Microbiology, Immunology and Parasitology, D 53105 Bonn, Germany
BMC Microbiol 6:91. 2006..falciparum. A comparison of the enzymatic properties of the DHS enzymes between the benign and severe Plasmodium species should contribute to our understanding of the differences in pathogenicity and phylogeny of both malaria parasites... 
Effects of 6-week azithromycin treatment on the Wolbachia endobacteria of Onchocerca volvulusAchim Hoerauf
Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Sigmund Freud Str 25, 53105, Bonn, Germany
Parasitol Res 103:279-86. 2008..But daily azithromycin should be studied in combination with other drugs and with other doses...- Immunomodulation by filarial nematodesA Hoerauf
Institute for Medical Parasitology, University Clinic Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Parasite Immunol 27:417-29. 2005.... - Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled studyAchim Hoerauf
Institute for Medical Microbiology, Immunology and Parasitology, University Clinic, Bonn, Sigmund Freud Strasse 25, Bonn, Germany
Med Microbiol Immunol 197:295-311. 2008..Doxycycline may be developed as second-line drug for onchocerciasis, to be administered in areas without transmission, in foci with IVM resistance and in areas with Loa co-infections... - Efficacy of 5-week doxycycline treatment on adult Onchocerca volvulusAchim Hoerauf
Institute for Medical Microbiology, Immunology and Parasitology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
Parasitol Res 104:437-47. 2009..However, doxycycline can be used for the treatment of individuals outside transmission areas, in foci where ivermectin resistance may occur, and in countries where onchocerciasis and loiasis are co-endemic... - Filariasis: new drugs and new opportunities for lymphatic filariasis and onchocerciasisAchim Hoerauf
Institute of Medical Microbiology, Immunology and Parasitology, University Bonn Medical Centre, Bonn, Germany
Curr Opin Infect Dis 21:673-81. 2008..This review details the recent indications for this new treatment, focussing on regimes for individual drug administration... - Filariasis in Africa--treatment challenges and prospectsA Hoerauf
Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Sigmund Freud Strasse, Bonn, Germany
Clin Microbiol Infect 17:977-85. 2011..Research into new treatment options is exploring several improved delivery strategies for the classic drugs or new antibiotic treatment regimens for anti-wolbachial chemotherapy... - The mitochondrial heat shock protein 60 (HSP60) is up-regulated in Onchocerca volvulus after the depletion of WolbachiaK M Pfarr
Institute for Medical Microbiology, Immunology and Parasitology, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
Parasitology 135:529-38. 2008..7 fold) compared with untreated worms. We hypothesize that the increased expression of HSP60 in the absence of Wolbachia is due to a disruption of the homeostasis of the endosymbiosis... - Interleukin-10 (IL-10) counterregulates IL-4-dependent effector mechanisms in Murine FilariasisSabine Specht
Institute for Medical Parasitology, Friedrich Wilhelm University of Bonn, Sigmund Freud Str 25, 53105, Germany
Infect Immun 72:6287-93. 2004..The finding that knockout of IL-10 reversed a disease phenotype induced by knockout of IL-4 gives the first causal evidence of an antagonistic activity between IL-4 and IL-10 in an infection in vivo... - Reduction in levels of plasma vascular endothelial growth factor-A and improvement in hydrocele patients by targeting endosymbiotic Wolbachia sp. in Wuchereria bancrofti with doxycyclineAlexander Y Debrah
Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany
Am J Trop Med Hyg 80:956-63. 2009..This finding preceded the reduction of the stage of hydrocele. A six-week regimen of doxycycline treatment against filariasis showed amelioration of pathologic conditions of hydrocele patients with active infection... - Ultrasonography in filaria-infected rodents: detection of adult Litomosoides sigmodontis and Brugia malayi filariaeS Mand
Institute of Medical Parasitology, Faculty of Medicine, Bonn University, Bonn, Germany
Trop Med Int Health 11:1382-7. 2006..To evaluate the usefulness of ultrasonography (USG) in the detection of adult filariae in rodents. Wuchereria bancrofti are frequently detected using USG in humans, whereas adult Brugia malayi have not been so far... - Lack of eosinophil peroxidase or major basic protein impairs defense against murine filarial infectionSabine Specht
Institute for Medical Microbiology, Immunology and Parasitology, Friedrich Wilhelm University Bonn, 53105 Bonn, Germany
Infect Immun 74:5236-43. 2006..These data suggest a hitherto unknown interaction between eosinophil granule proteins, defense against filarial nematodes, and cytokine responses of macrophages and CD4 T cells... - Transforming growth factor-beta expression by host cells is elicited locally by the filarial nematode Onchocerca volvulus in hyporeactive patients independently from WolbachiaSimone Korten
Institute of Medical Microbiology, Immunology and Parasitology IMMIP, University Clinic Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
Microbes Infect 12:555-64. 2010..TGF-beta(+) cells were reduced in HIV co-infection. This finding of local and sustained TGF-beta induction by vital and dead filariae, untreated and after treatment, adds new aspects to immunomodulation by helminths... - Filariasis and lymphoedemaK M Pfarr
Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany
Parasite Immunol 31:664-72. 2009.... - Low levels of transforming growth factor-beta (TGF-beta) and reduced suppression of Th2-mediated inflammation in hyperreactive human onchocerciasisS Korten
Institute for Medical Microbiology, Immunology and Parasitology, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
Parasitology 138:35-45. 2011..In conclusion, hyperreactivity is linked with reduced local expression of TGF-β, HLA-DR and IgG4, which might contribute to the insufficient down-regulation of inflammation via TGF-β- and HLA-DR-induced regulatory lymphocytes... - RNAi mediated silencing of actin expression in adult Litomosoides sigmodontis is specific, persistent and results in a phenotypeKenneth Pfarr
Institute for Medical Microbiology, Immunology and Parasitology, University Clinic Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Int J Parasitol 36:661-9. 2006..Thus, the use of lower dsRNA concentrations and proper controls for off-target effects make RNAi a viable method to study the function of filarial genes... - Efficacy of 2- and 4-week rifampicin treatment on the Wolbachia of Onchocerca volvulusSabine Specht
Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
Parasitol Res 103:1303-9. 2008..This treatment is less efficient than treatment with 6 weeks doxycycline, but might be an alternative for cases that cannot be treated with doxycycline, e.g. children, or might be further developed for combination therapy... - Core-specific adaptive regulatory T-cells in different outcomes of hepatitis CBettina Langhans
Department of Internal Medicine I, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Clin Sci (Lond) 119:97-109. 2010..Thus HCV core-specific Treg-cells may contribute to the immunoregulatory balance in chronic hepatitis C... - Doxycycline reduces plasma VEGF-C/sVEGFR-3 and improves pathology in lymphatic filariasisAlexander Yaw Debrah
Institute for Medical Microbiology, Immunology, and Parasitology, University of Bonn, Bonn, Germany
PLoS Pathog 2:e92. 2006.... - A niche for WolbachiaKenneth M Pfarr
Institute for Medical Microbiology, Immunology and Parasitology, University Clinic Bonn, Sigmund Freud Strasse 25, Bonn D 53105, Germany
Trends Parasitol 23:5-7. 2007..recently showed that, after transfer to uninfected Drosophila, Wolbachia rapidly accumulate in the somatic stem cell niche. From this location, the endobacteria might enter the developing oocytes and infect the progeny... - Newly acquired Onchocerca volvulus filariae after doxycycline treatmentSabine Specht
Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, 53105, Bonn, Germany
Parasitol Res 106:23-31. 2009..c) Only newly acquired worms presented normal embryogenesis and microfilariae production after sufficient treatment. We conclude that newly acquired filariae have to be considered when evaluating drug efficacy in onchocerciasis... - Macrofilaricidal effect of 4 weeks of treatment with doxycycline on Wuchereria bancroftiAlexander Yaw Debrah
Institute for Medical Microbiology, Immunology and Parasitology, University of Bonn, Bonn, Germany
Trop Med Int Health 12:1433-41. 2007..To evaluate the efficacy of doxycycline as a macrofilaricidal agent against Wuchereria bancrofti... - Bancroftian filariasis--absence of Wolbachia after doxycycline treatmentSabine Mand
Institute of Medical Microbiology, Immunology and Parasitology, University Clinic Bonn, Bonn, Germany
Am J Trop Med Hyg 78:854-5. 2008 - Induction of chronic colitis in IL-10 deficient mice requires IL-4Sabine Specht
Institute for Medical Parasitology, Friedrich Wilhelm University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Microbes Infect 8:694-703. 2006..Together these results indicate an important role of IL-4 for the onset of colitis in IL-10 KO mice by promoting a Th1 response and induction of a deleterious Th2 effector response... - Reliable and frequent detection of adult Wuchereria bancrofti in Ghanaian women by ultrasonographySabine Mand
Institute of Medical Parasitology, Faculty of Medicine, Bonn University, Bonn, Germany
Trop Med Int Health 9:1111-4. 2004..The surprisingly high number of worm nests detectable in microfilaraemic women recommends ultrasonography for diagnosis and treatment efficacy monitoring of female patients infected with W. bancrofti... - Differential display of genes expressed in the filarial nematode Litomosoides sigmodontis reveals a putative phosphate permease up-regulated after depletion of Wolbachia endobacteriaUlrike Heider
Institute for Medical Microbiology, Immunology and Parasitology, University Clinic Bonn, Sigmund-Freud-Strasse 25, D-53105 Bonn, Germany
Int J Med Microbiol 296:287-99. 2006..The potential role of Ls-ppe-1 in the nematode-bacterial symbiosis is discussed... - Filarial infection induces protection against P. berghei liver stages in miceDaniel Fernández Ruiz
Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Microbes Infect 11:172-80. 2009.... - Macrofilaricidal activity and amelioration of lymphatic pathology in bancroftian filariasis after 3 weeks of doxycycline followed by single-dose diethylcarbamazineSabine Mand
Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany
Am J Trop Med Hyg 81:702-11. 2009.... - The annotated genome of Wolbachia from the filarial nematode Brugia malayi: what it means for progress in antifilarial medicineKenneth Pfarr
Institute for Medical Parasitology, University of Bonn, Germany
PLoS Med 2:e110. 2005 - Mitochondrial genes for heme-dependent respiratory chain complexes are up-regulated after depletion of Wolbachia from filarial nematodesUta Strübing
Institute for Medical Microbiology, Immunology and Parasitology, University Clinic Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
Int J Parasitol 40:1193-202. 2010..Our results support targeting the Wolbachia heme synthesis pathway for the discovery of new anti-filarial drugs... - Filaria-induced IL-10 suppresses murine cerebral malariaSabine Specht
Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany
Microbes Infect 12:635-42. 2010..This suggests that the anti-inflammatory IL-10 elicited by filarial nematodes is able to suppress the overwhelming inflammatory reaction otherwise triggered against malaria parasites in C57BL/6 mice, preventing full progress to CM... - Differential expression of toll-like receptor 2 on dendritic cells from asymptomatic and symptomatic atopic donorsD von Bubnoff
Department of Dermatology and Allergology, University of Bonn, Bonn, Germany
Int Arch Allergy Immunol 159:41-50. 2012..Different expression of TLRs in symptomatic and asymptomatic atopic donors may contribute to the development of allergic disease... - Induction of immunoglobulin G4 in human filariasis: an indicator of immunoregulationT Adjobimey
Institute for Medical Microbiology, Immunology and Parasitology, University Clinic Bonn, Germany
Ann Trop Med Parasitol 104:455-64. 2010..Here, various aspects of the induction of IgG4 in humans and it roles in the immunomodulation of the human responses to filarial parasites are reviewed... - Control of filarial infections: not the beginning of the end, but more research is neededAchim Hoerauf
Institute of Medical Parasitology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Curr Opin Infect Dis 16:403-10. 2003.... - The guanylhydrazone CNI-1493: an inhibitor with dual activity against malaria-inhibition of host cell pro-inflammatory cytokine release and parasitic deoxyhypusine synthaseSabine Specht
Institute for Medical Microbiolgy, Immunology and Parasitology, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Parasitol Res 102:1177-84. 2008..From the current data, we consider CNI-1493 to be a promising drug for anti-malarial therapy because of its combined action, i.e., the decrease in eIF-5A biosynthesis of the parasite and host cell TNF biosynthesis... - Infection of the intermediate mite host with Wolbachia-depleted Litomosoides sigmodontis microfilariae: impaired L1 to L3 development and subsequent sex-ratio distortion in adult wormsSridhar Arumugam
Institute for Medical Microbiology, Immunology and Parasitology, University Clinic Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
Int J Parasitol 38:981-7. 2008.... - Detection of adult Brugia malayi filariae by ultrasonography in humans in India and IndonesiaS Mand
Institute of Medical Parasitology, Faculty of Medicine, Bonn University, Bonn, Germany
Trop Med Int Health 11:1375-81. 2006..The study shows that adult filariae of B. malayi in humans can be detected by USG, but the technique is limited by the fact that worm nests seem not to be stable over time in humans, as is the case in bancroftian filariasis... - Inhibition of hypusine biosynthesis in plasmodium: a possible, new strategy in prevention and therapy of malariaA Kaiser
Institute for Medical Parasitology, D 53105 Bonn, Germany
Mini Rev Med Chem 6:1231-41. 2006..Here, we describe a new class of compounds the piperidone 3-carboxylates which show an antiplasmodial effect in vitro and in vivo. This effect might be caused by inhibition of eukaryotic initiation factor (eIF-5A)... - Increased frequency of the CTLA-4 49 A/G polymorphism in patients with acquired haemophilia A compared to healthy controlsA Pavlova
Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, Bonn, Germany
Haemophilia 14:355-60. 2008..In conclusion, on the background of the CTLA-4 gene polymorphism, further genetic and/or environmental factors might contribute to and finally trigger the clinical manifestation of AH... - Tr1 and naturally occurring regulatory T cells induce IgG4 in B cells through GITR/GITR-L interaction, IL-10 and TGF-betaJudith S Satoguina
Institute of Medical Microbiology, Immunology and Parasitology, University Clinic Bonn, Bonn, Germany
Eur J Immunol 38:3101-13. 2008..Thus, the mechanism of IgG4 induction by regulatory cells involves GITR-GITR-L interactions, IL-10 and TGF-beta... - Heat shock protein 60 is released in immune-mediated glomerulonephritis and aggravates disease: in vivo evidence for an immunologic danger signalAndreas Lang
Institute of Molecular Medicine and Experimental Immunology, , 53105 Bonn, Germany
J Am Soc Nephrol 16:383-91. 2005..These findings demonstrate in vivo that Hsp60 fulfills criteria of immunologic danger signals and suggest that such signals may be involved in immune-mediated kidney disease... - Plasma vascular endothelial growth Factor-A (VEGF-A) and VEGF-A gene polymorphism are associated with hydrocele development in lymphatic filariasisAlexander Yaw Debrah
Institute for Medical Microbiology, Immunology and Parasitology, University of Bonn, Bonn, Germany
Am J Trop Med Hyg 77:601-8. 2007..412, P = 0.026) was observed between plasma VEGF-A and stage of hydrocele. The data suggest that the C polymorphism at -460 is a genetic risk factor for hydrocele development in lymphatic filariasis... - Pronounced phenotype in activated regulatory T cells during a chronic helminth infectionLaura E Layland
Institute for Medical Microbiology, Immunology and Hygiene, Technische Universitat Munchen, Munich, Germany
J Immunol 184:713-24. 2010..Using RT-PCR, we confirmed aspects of the microarray data and also showed that the expression profile of Tregs from S. mansoni-infected mice is simultaneously unique and comparable with Tregs derived from other infections... - Functional conservation of the lipid II biosynthesis pathway in the cell wall-less bacteria Chlamydia and Wolbachia: why is lipid II needed?Beate Henrichfreise
Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany
Mol Microbiol 73:913-23. 2009..Our results also indicate that the lipid II pathway may be exploited as an antibacterial target for chlamydial and filarial infections... - Piperidones with activity against Plasmodium falciparumMichael Saeftel
Institute for Medical Microbiology, Immunology and Parasitology, D-53105, Bonn, Germany
Parasitol Res 99:281-6. 2006..Using mimosine as a lead structure, alkyl 4-oxo-piperidine 3-carboxylates were found to have the most efficient antiplasmodial effects in vitro and in vivo... - Modification of eukaryotic initiation factor 5A from Plasmodium vivax by a truncated deoxyhypusine synthase from Plasmodium falciparum: An enzyme with dual enzymatic propertiesAnnette Kaiser
Institute for Medical Parasitology, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Bioorg Med Chem 15:6200-7. 2007..1 microM for the inhibitor GC7 being 2000-fold less than the nonguanylated derivative 1,7-diaminoheptane. Dhs transcription occurs in both develomental stages suggesting its necessity in cell proliferation... - Does helminth elimination promote or prevent malaria?Sabine Specht
Institute for Medical Microbiology, Immunology and Parasitology, University Clinic Bonn, 53105 Bonn, Germany
Lancet 369:446-7. 2007 - Antigen-specific T regulatory-1 cells are associated with immunosuppression in a chronic helminth infection (onchocerciasis)Judith Satoguina
Bernhard Nocht Institute of Tropical Medicine, Bernhard-Nocht-Strasse 74, 20359 Hamburg, Germany
Microbes Infect 4:1291-300. 2002..This is the first time that this type of suppressor T cell has been cloned as naturally occurring during an infectious disease... - The major surface protein of Wolbachia endosymbionts in filarial nematodes elicits immune responses through TLR2 and TLR4Norbert W Brattig
Tropical Medicine Section, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, D 20359 Hamburg, Germany
J Immunol 173:437-45. 2004..Thus, filarial helminths, through products of their endobacteria such as WSP, acquire characteristics of a typical microbial pathogen inducing immune responses via TLR2 and TLR4... - Antibiotics for the treatment of onchocerciasis and other filarial infectionsAchim Hoerauf
Department of Helminthology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
Curr Opin Investig Drugs 3:533-7. 2002..Indications of antiwolbachial therapy against onchocerciasis are discussed... - Involvement of Toll-like receptor 4 in the embryogenesis of the rodent filaria Litomosoides sigmodontisKenneth M Pfarr
Bernhard Nocht Institute for Tropical Medicine, Department of Helminthology, 20359 Hamburg, Germany
Med Microbiol Immunol 192:53-6. 2003..These results indicate a role for TLR4 signaling in the immune response that inhibits worm embryogenesis and prevents the release of microfilariae or directly kills released microfilariae... - A randomized, double-blind clinical trial of a 3-week course of doxycycline plus albendazole and ivermectin for the treatment of Wuchereria bancrofti infectionJoseph D Turner
Liverpool School of Tropical Medicine, Liverpool, United Kingdom
Clin Infect Dis 42:1081-9. 2006..Inflammatory reactions to antifilarial treatment are associated with levels of microfilariae and Wolbachia endosymbionts released into plasma... - Mass drug treatment for lymphatic filariasis and onchocerciasisDavid H Molyneux
Lymphatic Filariasis Support Centre, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
Trends Parasitol 19:516-22. 2003 - Synergism of gamma interferon and interleukin-5 in the control of murine filariasisMichael Saeftel
Bernhard Nocht Institute for Tropical Medicine, Department of Helminthology, 20359 Hamburg, Germany
Infect Immun 71:6978-85. 2003..Synergistic effects of the two cytokines may be mediated, at least in part, by neutrophils for the control of adult worms... - Macrofilaricidal activity after doxycycline treatment of Wuchereria bancrofti: a double-blind, randomised placebo-controlled trialMark J Taylor
Filariasis Research Group, Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Liverpool, UK
Lancet 365:2116-21. 2005..We used this strategy to investigate the effects of doxycycline treatment on the major cause of lymphatic filariasis, Wuchereria bancrofti... - Resistance and susceptibility in human onchocerciasis--beyond Th1 vs. Th2Achim Hoerauf
Bernhard Nocht Institute of Tropical Medicine, Bernhard Nocht Strasse 74, 20359, Hamburg, Germany
Trends Parasitol 18:25-31. 2002.... - Wolbachia bacterial endosymbionts of filarial nematodesMark J Taylor
Filariasis Research Laboratory, Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, UK
Adv Parasitol 60:245-84. 2005.... - Increased early local immune responses and altered worm development in high-dose infections of mice susceptible to the filaria Litomosoides sigmodontisSimon Babayan
, , 61 rue Buffon, 75213, Paris Cedex 05, France
Med Microbiol Immunol 194:151-62. 2005..This suggests that the very early events determine subsequent immune response and infection outcome rather than competitive interactions between the worms... - OnchocerciasisAchim Hoerauf
Bernhard Nocht Institute for Tropical Medicine, Department of Helminthology, Bernhard-Nocht-Strasse 74, 20359 Hamburg, Germany
BMJ 326:207-10. 2003 - The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindnessAmélie v Saint André
Division of Geographic Medicine, Department of Ophthalmology, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH 44106, USA
Science 295:1892-5. 2002..In addition, the inflammatory response induced by these bacteria was dependent on expression of functional Toll-like receptor 4 (TLR4) on host cells... - Doxycycline treatment of Brugia malayi-infected persons reduces microfilaremia and adverse reactions after diethylcarbamazine and albendazole treatmentTaniawati Supali
Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
Clin Infect Dis 46:1385-93. 2008..We assessed whether doxycycline alone or in combination with diethylcarbamazine-albendazole would lead to sustained amicrofilaremia and reduced incidence of adverse reactions... - Antibiotic therapy in murine filariasis (Litomosoides sigmodontis): comparative effects of doxycycline and rifampicin on Wolbachia and filarial viabilityLars Volkmann
Department of Helminthology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
Trop Med Int Health 8:392-401. 2003.... - Helminth infection with Litomosoides sigmodontis induces regulatory T cells and inhibits allergic sensitization, airway inflammation, and hyperreactivity in a murine asthma modelAnna M Dittrich
Department of Pediatric Pneumology and Immunology, Charite Campus Virchow Klinikum, Universitätsmedizin in Berlin, Augustenburger Platz 1, Germany
J Immunol 180:1792-9. 2008..In conclusion, our data support the epidemiological evidence and enhance the immunological understanding concerning the impact of helminth infections on atopic diseases thus providing new insights for the development of future studies... - Doxycycline in the treatment of human onchocerciasis: Kinetics of Wolbachia endobacteria reduction and of inhibition of embryogenesis in female Onchocerca wormsAchim Hoerauf
Department of Helminthology, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
Microbes Infect 5:261-73. 2003..Extension of the existing registration will not require much time or high cost. Treatment of individual patients can be considered immediately... - Doxycycline as a novel strategy against bancroftian filariasis-depletion of Wolbachia endosymbionts from Wuchereria bancrofti and stop of microfilaria productionAchim Hoerauf
Department of Helminthology, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
Med Microbiol Immunol 192:211-6. 2003..This could render doxycycline treatment an additional tool for the treatment of microfilaria-associated diseases in bancroftian filariasis, such as tropical pulmonary eosinophilia and microfiluria... - Murine filariasis: interleukin 4 and interleukin 5 lead to containment of different worm developmental stagesLars Volkmann
Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
Med Microbiol Immunol 192:23-31. 2003..factor of 160 in full infection). In conclusion, IL-4 and IL-5 dependent effector pathways operate against different stages of filarial worms, and IL-5 has a greater impact on parasite containment than IL-4... - Mice deficient in interleukin-4 (IL-4) or IL-4 receptor alpha have higher resistance to sporozoite infection with Plasmodium berghei (ANKA) than do naive wild-type miceMichael Saeftel
Section of Immunology, Bernhard Nocht Institute for Tropical Medicine, D 20359 Hamburg, Germany
Infect Immun 72:322-31. 2004..The absence of IL-4-mediated functions increases the protective innate immune mechanism identified above, which results in immunity against P. berghei infection in these mice, with no major role for IL-13... - In search of novel agents for therapy of tropical diseases and human immunodeficiency virusTim Goebel
Institute of Pharmacy and Food Chemistry, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany
J Med Chem 51:238-50. 2008..brucei brucei. The piperidine oximether 53 demonstrated the highest plasmodicidal activity. Moreover, compounds 11 and 53 were also able to inhibit replication of HIV-1... - Natural death of adult Onchocerca volvulus and filaricidal effects of doxycycline induce local FOXP3+/CD4+ regulatory T cells and granzyme expressionSimone Korten
Department of Immunology, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, D 20359 Hamburg, Germany
Microbes Infect 10:313-24. 2008..We newly report granzyme responses to helminths and their association with immunosuppression. FOXP3+Treg and granzyme+ cells might locally suppress defence against newly acquired worms... - On the taxonomic status of the intracellular bacterium Wolbachia pipientis: should this species name include the intracellular bacteria of filarial nematodes?Kenneth Pfarr
Int J Syst Evol Microbiol 57:1677-8. 2007 - Expansion of NK cells with reduction of their inhibitory Ly-49A, Ly-49C, and Ly-49G2 receptor-expressing subsets in a murine helminth infection: contribution to parasite controlSimone Korten
Department of Medical Microbiology and Immunology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
J Immunol 168:5199-206. 2002..These data demonstrate a new role for NK cells in the host defense against filariae and, for the first time, alterations of Ly-49 receptor-expressing NK cell subsets in a parasitic infection... - The variant Arg110Gln of human IL-13 is associated with an immunologically hyper-reactive form of onchocerciasis (sowda)Achim Hoerauf
Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
Microbes Infect 4:37-42. 2002..Arg110Gln has been suggested to lead to enhanced IL-13 signaling and thus may be involved in shifting the immune reaction towards the hyper-reactivity characteristic for the sowda form, thereby promoting defense mechanisms... - More research needed to consolidate achievements in filariasis controlAchim Hoerauf
Bernhard Nocht Institute of Tropical Medicine, 20359 Hamburg, Germany
Med Microbiol Immunol 192:1-2. 2003 - Newbouldiaquinone A: A naphthoquinone-anthraquinone ether coupled pigment, as a potential antimicrobial and antimalarial agent from Newbouldia laevisKenneth Oben Eyong
Department of Organic Chemistry, Yaounde University I, P.O. Box 812, Yaounde, Cameroon
Phytochemistry 67:605-9. 2006..Its antimicrobial activity against a wide range of microorganisms was 13- and 24-fold more active against Candida gabrata and Enterobacter aerogens than the reference antibiotics nystatin and gentamycin...