A Hoerauf

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. ncbi request reprint T regulatory-1 cells induce IgG4 production by B cells: role of IL-10
    Judith S Satoguina
    Institute of Medical Parasitology, Friedrich Wilhelm University of Bonn, Bonn, Germany
    J Immunol 174:4718-26. 2005
  2. ncbi request reprint New strategies to combat filariasis
    Achim Hoerauf
    Institute of Medical Microbiology, Immunology and Parasitology, University Clinic Bonn, 53105 Bonn, Germany
    Expert Rev Anti Infect Ther 4:211-22. 2006
  3. pmc Onchocerciasis Control: Vision for the Future from a Ghanian perspective
    Mark J Taylor
    Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Liverpool, UK
    Parasit Vectors 2:7. 2009
  4. pmc Cloning, expression and functional activity of deoxyhypusine synthase from Plasmodium vivax
    James T Njuguna
    Institute for Medical Microbiology, Immunology and Parasitology, D 53105 Bonn, Germany
    BMC Microbiol 6:91. 2006
  5. pmc Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study
    Achim Hoerauf
    Institute for Medical Microbiology, Immunology and Parasitology, University Clinic, Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Med Microbiol Immunol 197:295-311. 2008
  6. doi request reprint Efficacy of 5-week doxycycline treatment on adult Onchocerca volvulus
    Achim Hoerauf
    Institute for Medical Microbiology, Immunology and Parasitology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Parasitol Res 104:437-47. 2009
  7. ncbi request reprint Immunomodulation by filarial nematodes
    A Hoerauf
    Institute for Medical Parasitology, University Clinic Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Parasite Immunol 27:417-29. 2005
  8. doi request reprint Effects of 6-week azithromycin treatment on the Wolbachia endobacteria of Onchocerca volvulus
    Achim Hoerauf
    Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Sigmund Freud Str 25, 53105, Bonn, Germany
    Parasitol Res 103:279-86. 2008
  9. doi request reprint Filariasis: new drugs and new opportunities for lymphatic filariasis and onchocerciasis
    Achim Hoerauf
    Institute of Medical Microbiology, Immunology and Parasitology, University Bonn Medical Centre, Bonn, Germany
    Curr Opin Infect Dis 21:673-81. 2008
  10. doi request reprint Filariasis in Africa--treatment challenges and prospects
    A Hoerauf
    Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Sigmund Freud Strasse, Bonn, Germany
    Clin Microbiol Infect 17:977-85. 2011

Collaborators

Detail Information

Publications78

  1. ncbi request reprint T regulatory-1 cells induce IgG4 production by B cells: role of IL-10
    Judith S Satoguina
    Institute of Medical Parasitology, Friedrich Wilhelm University of Bonn, Bonn, Germany
    J Immunol 174:4718-26. 2005
    ..The correlation between IgG4 and IL-10 (r2 = 0.352) indicates that IL-10 is an important but not the only factor for IgG4 induction...
  2. ncbi request reprint New strategies to combat filariasis
    Achim Hoerauf
    Institute of Medical Microbiology, Immunology and Parasitology, University Clinic Bonn, 53105 Bonn, Germany
    Expert Rev Anti Infect Ther 4:211-22. 2006
    ....
  3. pmc Onchocerciasis Control: Vision for the Future from a Ghanian perspective
    Mark J Taylor
    Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Liverpool, UK
    Parasit Vectors 2:7. 2009
    ....
  4. pmc Cloning, expression and functional activity of deoxyhypusine synthase from Plasmodium vivax
    James T Njuguna
    Institute for Medical Microbiology, Immunology and Parasitology, D 53105 Bonn, Germany
    BMC Microbiol 6:91. 2006
    ..falciparum. A comparison of the enzymatic properties of the DHS enzymes between the benign and severe Plasmodium species should contribute to our understanding of the differences in pathogenicity and phylogeny of both malaria parasites...
  5. pmc Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study
    Achim Hoerauf
    Institute for Medical Microbiology, Immunology and Parasitology, University Clinic, Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Med Microbiol Immunol 197:295-311. 2008
    ..Doxycycline may be developed as second-line drug for onchocerciasis, to be administered in areas without transmission, in foci with IVM resistance and in areas with Loa co-infections...
  6. doi request reprint Efficacy of 5-week doxycycline treatment on adult Onchocerca volvulus
    Achim Hoerauf
    Institute for Medical Microbiology, Immunology and Parasitology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Parasitol Res 104:437-47. 2009
    ..However, doxycycline can be used for the treatment of individuals outside transmission areas, in foci where ivermectin resistance may occur, and in countries where onchocerciasis and loiasis are co-endemic...
  7. ncbi request reprint Immunomodulation by filarial nematodes
    A Hoerauf
    Institute for Medical Parasitology, University Clinic Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Parasite Immunol 27:417-29. 2005
    ....
  8. doi request reprint Effects of 6-week azithromycin treatment on the Wolbachia endobacteria of Onchocerca volvulus
    Achim Hoerauf
    Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Sigmund Freud Str 25, 53105, Bonn, Germany
    Parasitol Res 103:279-86. 2008
    ..But daily azithromycin should be studied in combination with other drugs and with other doses...
  9. doi request reprint Filariasis: new drugs and new opportunities for lymphatic filariasis and onchocerciasis
    Achim Hoerauf
    Institute of Medical Microbiology, Immunology and Parasitology, University Bonn Medical Centre, Bonn, Germany
    Curr Opin Infect Dis 21:673-81. 2008
    ..This review details the recent indications for this new treatment, focussing on regimes for individual drug administration...
  10. doi request reprint Filariasis in Africa--treatment challenges and prospects
    A Hoerauf
    Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Sigmund Freud Strasse, Bonn, Germany
    Clin Microbiol Infect 17:977-85. 2011
    ..Research into new treatment options is exploring several improved delivery strategies for the classic drugs or new antibiotic treatment regimens for anti-wolbachial chemotherapy...
  11. doi request reprint The mitochondrial heat shock protein 60 (HSP60) is up-regulated in Onchocerca volvulus after the depletion of Wolbachia
    K M Pfarr
    Institute for Medical Microbiology, Immunology and Parasitology, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Parasitology 135:529-38. 2008
    ..7 fold) compared with untreated worms. We hypothesize that the increased expression of HSP60 in the absence of Wolbachia is due to a disruption of the homeostasis of the endosymbiosis...
  12. ncbi request reprint Reduction in levels of plasma vascular endothelial growth factor-A and improvement in hydrocele patients by targeting endosymbiotic Wolbachia sp. in Wuchereria bancrofti with doxycycline
    Alexander Y Debrah
    Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany
    Am J Trop Med Hyg 80:956-63. 2009
    ..This finding preceded the reduction of the stage of hydrocele. A six-week regimen of doxycycline treatment against filariasis showed amelioration of pathologic conditions of hydrocele patients with active infection...
  13. pmc Interleukin-10 (IL-10) counterregulates IL-4-dependent effector mechanisms in Murine Filariasis
    Sabine Specht
    Institute for Medical Parasitology, Friedrich Wilhelm University of Bonn, Sigmund Freud Str 25, 53105, Germany
    Infect Immun 72:6287-93. 2004
    ..The finding that knockout of IL-10 reversed a disease phenotype induced by knockout of IL-4 gives the first causal evidence of an antagonistic activity between IL-4 and IL-10 in an infection in vivo...
  14. ncbi request reprint Ultrasonography in filaria-infected rodents: detection of adult Litomosoides sigmodontis and Brugia malayi filariae
    S Mand
    Institute of Medical Parasitology, Faculty of Medicine, Bonn University, Bonn, Germany
    Trop Med Int Health 11:1382-7. 2006
    ..To evaluate the usefulness of ultrasonography (USG) in the detection of adult filariae in rodents. Wuchereria bancrofti are frequently detected using USG in humans, whereas adult Brugia malayi have not been so far...
  15. pmc Lack of eosinophil peroxidase or major basic protein impairs defense against murine filarial infection
    Sabine Specht
    Institute for Medical Microbiology, Immunology and Parasitology, Friedrich Wilhelm University Bonn, 53105 Bonn, Germany
    Infect Immun 74:5236-43. 2006
    ..These data suggest a hitherto unknown interaction between eosinophil granule proteins, defense against filarial nematodes, and cytokine responses of macrophages and CD4 T cells...
  16. doi request reprint Transforming growth factor-beta expression by host cells is elicited locally by the filarial nematode Onchocerca volvulus in hyporeactive patients independently from Wolbachia
    Simone Korten
    Institute of Medical Microbiology, Immunology and Parasitology IMMIP, University Clinic Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Microbes Infect 12:555-64. 2010
    ..TGF-beta(+) cells were reduced in HIV co-infection. This finding of local and sustained TGF-beta induction by vital and dead filariae, untreated and after treatment, adds new aspects to immunomodulation by helminths...
  17. pmc Low levels of transforming growth factor-beta (TGF-beta) and reduced suppression of Th2-mediated inflammation in hyperreactive human onchocerciasis
    S Korten
    Institute for Medical Microbiology, Immunology and Parasitology, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Parasitology 138:35-45. 2011
    ..In conclusion, hyperreactivity is linked with reduced local expression of TGF-β, HLA-DR and IgG4, which might contribute to the insufficient down-regulation of inflammation via TGF-β- and HLA-DR-induced regulatory lymphocytes...
  18. pmc Filariasis and lymphoedema
    K M Pfarr
    Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany
    Parasite Immunol 31:664-72. 2009
    ....
  19. doi request reprint Efficacy of 2- and 4-week rifampicin treatment on the Wolbachia of Onchocerca volvulus
    Sabine Specht
    Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Parasitol Res 103:1303-9. 2008
    ..This treatment is less efficient than treatment with 6 weeks doxycycline, but might be an alternative for cases that cannot be treated with doxycycline, e.g. children, or might be further developed for combination therapy...
  20. ncbi request reprint Induction of chronic colitis in IL-10 deficient mice requires IL-4
    Sabine Specht
    Institute for Medical Parasitology, Friedrich Wilhelm University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Microbes Infect 8:694-703. 2006
    ..Together these results indicate an important role of IL-4 for the onset of colitis in IL-10 KO mice by promoting a Th1 response and induction of a deleterious Th2 effector response...
  21. pmc Newly acquired Onchocerca volvulus filariae after doxycycline treatment
    Sabine Specht
    Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, 53105, Bonn, Germany
    Parasitol Res 106:23-31. 2009
    ..c) Only newly acquired worms presented normal embryogenesis and microfilariae production after sufficient treatment. We conclude that newly acquired filariae have to be considered when evaluating drug efficacy in onchocerciasis...
  22. ncbi request reprint RNAi mediated silencing of actin expression in adult Litomosoides sigmodontis is specific, persistent and results in a phenotype
    Kenneth Pfarr
    Institute for Medical Microbiology, Immunology and Parasitology, University Clinic Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Int J Parasitol 36:661-9. 2006
    ..Thus, the use of lower dsRNA concentrations and proper controls for off-target effects make RNAi a viable method to study the function of filarial genes...
  23. ncbi request reprint Bancroftian filariasis--absence of Wolbachia after doxycycline treatment
    Sabine Mand
    Institute of Medical Microbiology, Immunology and Parasitology, University Clinic Bonn, Bonn, Germany
    Am J Trop Med Hyg 78:854-5. 2008
  24. ncbi request reprint A niche for Wolbachia
    Kenneth M Pfarr
    Institute for Medical Microbiology, Immunology and Parasitology, University Clinic Bonn, Sigmund Freud Strasse 25, Bonn D 53105, Germany
    Trends Parasitol 23:5-7. 2007
    ..recently showed that, after transfer to uninfected Drosophila, Wolbachia rapidly accumulate in the somatic stem cell niche. From this location, the endobacteria might enter the developing oocytes and infect the progeny...
  25. pmc Doxycycline reduces plasma VEGF-C/sVEGFR-3 and improves pathology in lymphatic filariasis
    Alexander Yaw Debrah
    Institute for Medical Microbiology, Immunology, and Parasitology, University of Bonn, Bonn, Germany
    PLoS Pathog 2:e92. 2006
    ....
  26. doi request reprint Core-specific adaptive regulatory T-cells in different outcomes of hepatitis C
    Bettina Langhans
    Department of Internal Medicine I, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Clin Sci (Lond) 119:97-109. 2010
    ..Thus HCV core-specific Treg-cells may contribute to the immunoregulatory balance in chronic hepatitis C...
  27. ncbi request reprint Macrofilaricidal effect of 4 weeks of treatment with doxycycline on Wuchereria bancrofti
    Alexander Yaw Debrah
    Institute for Medical Microbiology, Immunology and Parasitology, University of Bonn, Bonn, Germany
    Trop Med Int Health 12:1433-41. 2007
    ..To evaluate the efficacy of doxycycline as a macrofilaricidal agent against Wuchereria bancrofti...
  28. ncbi request reprint Reliable and frequent detection of adult Wuchereria bancrofti in Ghanaian women by ultrasonography
    Sabine Mand
    Institute of Medical Parasitology, Faculty of Medicine, Bonn University, Bonn, Germany
    Trop Med Int Health 9:1111-4. 2004
    ..The surprisingly high number of worm nests detectable in microfilaraemic women recommends ultrasonography for diagnosis and treatment efficacy monitoring of female patients infected with W. bancrofti...
  29. doi request reprint Filarial infection induces protection against P. berghei liver stages in mice
    Daniel Fernández Ruiz
    Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Microbes Infect 11:172-80. 2009
    ....
  30. doi request reprint Filaria-induced IL-10 suppresses murine cerebral malaria
    Sabine Specht
    Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany
    Microbes Infect 12:635-42. 2010
    ..This suggests that the anti-inflammatory IL-10 elicited by filarial nematodes is able to suppress the overwhelming inflammatory reaction otherwise triggered against malaria parasites in C57BL/6 mice, preventing full progress to CM...
  31. ncbi request reprint Differential display of genes expressed in the filarial nematode Litomosoides sigmodontis reveals a putative phosphate permease up-regulated after depletion of Wolbachia endobacteria
    Ulrike Heider
    Institute for Medical Microbiology, Immunology and Parasitology, University Clinic Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Int J Med Microbiol 296:287-99. 2006
    ..The potential role of Ls-ppe-1 in the nematode-bacterial symbiosis is discussed...
  32. doi request reprint Mitochondrial genes for heme-dependent respiratory chain complexes are up-regulated after depletion of Wolbachia from filarial nematodes
    Uta Strübing
    Institute for Medical Microbiology, Immunology and Parasitology, University Clinic Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Int J Parasitol 40:1193-202. 2010
    ..Our results support targeting the Wolbachia heme synthesis pathway for the discovery of new anti-filarial drugs...
  33. doi request reprint Macrofilaricidal activity and amelioration of lymphatic pathology in bancroftian filariasis after 3 weeks of doxycycline followed by single-dose diethylcarbamazine
    Sabine Mand
    Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany
    Am J Trop Med Hyg 81:702-11. 2009
    ....
  34. pmc The annotated genome of Wolbachia from the filarial nematode Brugia malayi: what it means for progress in antifilarial medicine
    Kenneth Pfarr
    Institute for Medical Parasitology, University of Bonn, Germany
    PLoS Med 2:e110. 2005
  35. doi request reprint Differential expression of toll-like receptor 2 on dendritic cells from asymptomatic and symptomatic atopic donors
    D von Bubnoff
    Department of Dermatology and Allergology, University of Bonn, Bonn, Germany
    Int Arch Allergy Immunol 159:41-50. 2012
    ..Different expression of TLRs in symptomatic and asymptomatic atopic donors may contribute to the development of allergic disease...
  36. pmc Induction of immunoglobulin G4 in human filariasis: an indicator of immunoregulation
    T Adjobimey
    Institute for Medical Microbiology, Immunology and Parasitology, University Clinic Bonn, Germany
    Ann Trop Med Parasitol 104:455-64. 2010
    ..Here, various aspects of the induction of IgG4 in humans and it roles in the immunomodulation of the human responses to filarial parasites are reviewed...
  37. doi request reprint The guanylhydrazone CNI-1493: an inhibitor with dual activity against malaria-inhibition of host cell pro-inflammatory cytokine release and parasitic deoxyhypusine synthase
    Sabine Specht
    Institute for Medical Microbiolgy, Immunology and Parasitology, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Parasitol Res 102:1177-84. 2008
    ..From the current data, we consider CNI-1493 to be a promising drug for anti-malarial therapy because of its combined action, i.e., the decrease in eIF-5A biosynthesis of the parasite and host cell TNF biosynthesis...
  38. ncbi request reprint Control of filarial infections: not the beginning of the end, but more research is needed
    Achim Hoerauf
    Institute of Medical Parasitology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Curr Opin Infect Dis 16:403-10. 2003
    ....
  39. doi request reprint Infection of the intermediate mite host with Wolbachia-depleted Litomosoides sigmodontis microfilariae: impaired L1 to L3 development and subsequent sex-ratio distortion in adult worms
    Sridhar Arumugam
    Institute for Medical Microbiology, Immunology and Parasitology, University Clinic Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Int J Parasitol 38:981-7. 2008
    ....
  40. doi request reprint Eotaxin-1 is involved in parasite clearance during chronic filarial infection
    K Gentil
    Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany
    Parasite Immunol 36:60-77. 2014
    ....
  41. ncbi request reprint Inhibition of hypusine biosynthesis in plasmodium: a possible, new strategy in prevention and therapy of malaria
    A Kaiser
    Institute for Medical Parasitology, D 53105 Bonn, Germany
    Mini Rev Med Chem 6:1231-41. 2006
    ..Here, we describe a new class of compounds the piperidone 3-carboxylates which show an antiplasmodial effect in vitro and in vivo. This effect might be caused by inhibition of eukaryotic initiation factor (eIF-5A)...
  42. ncbi request reprint Detection of adult Brugia malayi filariae by ultrasonography in humans in India and Indonesia
    S Mand
    Institute of Medical Parasitology, Faculty of Medicine, Bonn University, Bonn, Germany
    Trop Med Int Health 11:1375-81. 2006
    ..The study shows that adult filariae of B. malayi in humans can be detected by USG, but the technique is limited by the fact that worm nests seem not to be stable over time in humans, as is the case in bancroftian filariasis...
  43. ncbi request reprint Increased frequency of the CTLA-4 49 A/G polymorphism in patients with acquired haemophilia A compared to healthy controls
    A Pavlova
    Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, Bonn, Germany
    Haemophilia 14:355-60. 2008
    ..In conclusion, on the background of the CTLA-4 gene polymorphism, further genetic and/or environmental factors might contribute to and finally trigger the clinical manifestation of AH...
  44. ncbi request reprint Heat shock protein 60 is released in immune-mediated glomerulonephritis and aggravates disease: in vivo evidence for an immunologic danger signal
    Andreas Lang
    Institute of Molecular Medicine and Experimental Immunology, Friedrich Wilhelms Universität, 53105 Bonn, Germany
    J Am Soc Nephrol 16:383-91. 2005
    ..These findings demonstrate in vivo that Hsp60 fulfills criteria of immunologic danger signals and suggest that such signals may be involved in immune-mediated kidney disease...
  45. ncbi request reprint Plasma vascular endothelial growth Factor-A (VEGF-A) and VEGF-A gene polymorphism are associated with hydrocele development in lymphatic filariasis
    Alexander Yaw Debrah
    Institute for Medical Microbiology, Immunology and Parasitology, University of Bonn, Bonn, Germany
    Am J Trop Med Hyg 77:601-8. 2007
    ..412, P = 0.026) was observed between plasma VEGF-A and stage of hydrocele. The data suggest that the C polymorphism at -460 is a genetic risk factor for hydrocele development in lymphatic filariasis...
  46. doi request reprint Tr1 and naturally occurring regulatory T cells induce IgG4 in B cells through GITR/GITR-L interaction, IL-10 and TGF-beta
    Judith S Satoguina
    Institute of Medical Microbiology, Immunology and Parasitology, University Clinic Bonn, Bonn, Germany
    Eur J Immunol 38:3101-13. 2008
    ..Thus, the mechanism of IgG4 induction by regulatory cells involves GITR-GITR-L interactions, IL-10 and TGF-beta...
  47. doi request reprint Pronounced phenotype in activated regulatory T cells during a chronic helminth infection
    Laura E Layland
    Institute for Medical Microbiology, Immunology and Hygiene, Technische Universitat Munchen, Munich, Germany
    J Immunol 184:713-24. 2010
    ..Using RT-PCR, we confirmed aspects of the microarray data and also showed that the expression profile of Tregs from S. mansoni-infected mice is simultaneously unique and comparable with Tregs derived from other infections...
  48. doi request reprint Functional conservation of the lipid II biosynthesis pathway in the cell wall-less bacteria Chlamydia and Wolbachia: why is lipid II needed?
    Beate Henrichfreise
    Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany
    Mol Microbiol 73:913-23. 2009
    ..Our results also indicate that the lipid II pathway may be exploited as an antibacterial target for chlamydial and filarial infections...
  49. ncbi request reprint Piperidones with activity against Plasmodium falciparum
    Michael Saeftel
    Institute for Medical Microbiology, Immunology and Parasitology, D 53105, Bonn, Germany
    Parasitol Res 99:281-6. 2006
    ..Using mimosine as a lead structure, alkyl 4-oxo-piperidine 3-carboxylates were found to have the most efficient antiplasmodial effects in vitro and in vivo...
  50. ncbi request reprint Modification of eukaryotic initiation factor 5A from Plasmodium vivax by a truncated deoxyhypusine synthase from Plasmodium falciparum: An enzyme with dual enzymatic properties
    Annette Kaiser
    Institute for Medical Parasitology, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Bioorg Med Chem 15:6200-7. 2007
    ..1 microM for the inhibitor GC7 being 2000-fold less than the nonguanylated derivative 1,7-diaminoheptane. Dhs transcription occurs in both develomental stages suggesting its necessity in cell proliferation...
  51. ncbi request reprint Does helminth elimination promote or prevent malaria?
    Sabine Specht
    Institute for Medical Microbiology, Immunology and Parasitology, University Clinic Bonn, 53105 Bonn, Germany
    Lancet 369:446-7. 2007
  52. ncbi request reprint Antibiotic therapy in murine filariasis (Litomosoides sigmodontis): comparative effects of doxycycline and rifampicin on Wolbachia and filarial viability
    Lars Volkmann
    Department of Helminthology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Trop Med Int Health 8:392-401. 2003
    ....
  53. ncbi request reprint Doxycycline in the treatment of human onchocerciasis: Kinetics of Wolbachia endobacteria reduction and of inhibition of embryogenesis in female Onchocerca worms
    Achim Hoerauf
    Department of Helminthology, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
    Microbes Infect 5:261-73. 2003
    ..Extension of the existing registration will not require much time or high cost. Treatment of individual patients can be considered immediately...
  54. ncbi request reprint Doxycycline as a novel strategy against bancroftian filariasis-depletion of Wolbachia endosymbionts from Wuchereria bancrofti and stop of microfilaria production
    Achim Hoerauf
    Department of Helminthology, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
    Med Microbiol Immunol 192:211-6. 2003
    ..This could render doxycycline treatment an additional tool for the treatment of microfilaria-associated diseases in bancroftian filariasis, such as tropical pulmonary eosinophilia and microfiluria...
  55. ncbi request reprint Involvement of Toll-like receptor 4 in the embryogenesis of the rodent filaria Litomosoides sigmodontis
    Kenneth M Pfarr
    Bernhard Nocht Institute for Tropical Medicine, Department of Helminthology, 20359 Hamburg, Germany
    Med Microbiol Immunol 192:53-6. 2003
    ..These results indicate a role for TLR4 signaling in the immune response that inhibits worm embryogenesis and prevents the release of microfilariae or directly kills released microfilariae...
  56. ncbi request reprint Murine filariasis: interleukin 4 and interleukin 5 lead to containment of different worm developmental stages
    Lars Volkmann
    Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Med Microbiol Immunol 192:23-31. 2003
    ..factor of 160 in full infection). In conclusion, IL-4 and IL-5 dependent effector pathways operate against different stages of filarial worms, and IL-5 has a greater impact on parasite containment than IL-4...
  57. pmc Onchocerciasis
    Achim Hoerauf
    Bernhard Nocht Institute for Tropical Medicine, Department of Helminthology, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
    BMJ 326:207-10. 2003
  58. ncbi request reprint In search of novel agents for therapy of tropical diseases and human immunodeficiency virus
    Tim Goebel
    Institute of Pharmacy and Food Chemistry, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany
    J Med Chem 51:238-50. 2008
    ..brucei brucei. The piperidine oximether 53 demonstrated the highest plasmodicidal activity. Moreover, compounds 11 and 53 were also able to inhibit replication of HIV-1...
  59. ncbi request reprint Antigen-specific T regulatory-1 cells are associated with immunosuppression in a chronic helminth infection (onchocerciasis)
    Judith Satoguina
    Bernhard Nocht Institute of Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
    Microbes Infect 4:1291-300. 2002
    ..This is the first time that this type of suppressor T cell has been cloned as naturally occurring during an infectious disease...
  60. ncbi request reprint Antibiotics for the treatment of onchocerciasis and other filarial infections
    Achim Hoerauf
    Department of Helminthology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    Curr Opin Investig Drugs 3:533-7. 2002
    ..Indications of antiwolbachial therapy against onchocerciasis are discussed...
  61. ncbi request reprint The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindness
    Amélie v Saint André
    Division of Geographic Medicine, Department of Ophthalmology, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH 44106, USA
    Science 295:1892-5. 2002
    ..In addition, the inflammatory response induced by these bacteria was dependent on expression of functional Toll-like receptor 4 (TLR4) on host cells...
  62. ncbi request reprint Resistance and susceptibility in human onchocerciasis--beyond Th1 vs. Th2
    Achim Hoerauf
    Bernhard Nocht Institute of Tropical Medicine, Bernhard Nocht Strasse 74, 20359, Hamburg, Germany
    Trends Parasitol 18:25-31. 2002
    ....
  63. ncbi request reprint Mass drug treatment for lymphatic filariasis and onchocerciasis
    David H Molyneux
    Lymphatic Filariasis Support Centre, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Trends Parasitol 19:516-22. 2003
  64. pmc Synergism of gamma interferon and interleukin-5 in the control of murine filariasis
    Michael Saeftel
    Bernhard Nocht Institute for Tropical Medicine, Department of Helminthology, 20359 Hamburg, Germany
    Infect Immun 71:6978-85. 2003
    ..Synergistic effects of the two cytokines may be mediated, at least in part, by neutrophils for the control of adult worms...
  65. pmc Mice deficient in interleukin-4 (IL-4) or IL-4 receptor alpha have higher resistance to sporozoite infection with Plasmodium berghei (ANKA) than do naive wild-type mice
    Michael Saeftel
    Section of Immunology, Bernhard Nocht Institute for Tropical Medicine, D 20359 Hamburg, Germany
    Infect Immun 72:322-31. 2004
    ..The absence of IL-4-mediated functions increases the protective innate immune mechanism identified above, which results in immunity against P. berghei infection in these mice, with no major role for IL-13...
  66. ncbi request reprint Helminth infection with Litomosoides sigmodontis induces regulatory T cells and inhibits allergic sensitization, airway inflammation, and hyperreactivity in a murine asthma model
    Anna M Dittrich
    Department of Pediatric Pneumology and Immunology, Charite Campus Virchow Klinikum, Universitätsmedizin in Berlin, Augustenburger Platz 1, Germany
    J Immunol 180:1792-9. 2008
    ..In conclusion, our data support the epidemiological evidence and enhance the immunological understanding concerning the impact of helminth infections on atopic diseases thus providing new insights for the development of future studies...
  67. doi request reprint Natural death of adult Onchocerca volvulus and filaricidal effects of doxycycline induce local FOXP3+/CD4+ regulatory T cells and granzyme expression
    Simone Korten
    Department of Immunology, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, D 20359 Hamburg, Germany
    Microbes Infect 10:313-24. 2008
    ..We newly report granzyme responses to helminths and their association with immunosuppression. FOXP3+Treg and granzyme+ cells might locally suppress defence against newly acquired worms...
  68. doi request reprint Doxycycline treatment of Brugia malayi-infected persons reduces microfilaremia and adverse reactions after diethylcarbamazine and albendazole treatment
    Taniawati Supali
    Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
    Clin Infect Dis 46:1385-93. 2008
    ..We assessed whether doxycycline alone or in combination with diethylcarbamazine-albendazole would lead to sustained amicrofilaremia and reduced incidence of adverse reactions...
  69. ncbi request reprint A randomized, double-blind clinical trial of a 3-week course of doxycycline plus albendazole and ivermectin for the treatment of Wuchereria bancrofti infection
    Joseph D Turner
    Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    Clin Infect Dis 42:1081-9. 2006
    ..We assessed whether a shorter (i.e, 3-week) course of doxycycline with standard treatment would show superior efficacy to standard treatment alone and reduce the incidence of adverse reactions...
  70. ncbi request reprint Wolbachia bacterial endosymbionts of filarial nematodes
    Mark J Taylor
    Filariasis Research Laboratory, Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, UK
    Adv Parasitol 60:245-84. 2005
    ....
  71. ncbi request reprint Macrofilaricidal activity after doxycycline treatment of Wuchereria bancrofti: a double-blind, randomised placebo-controlled trial
    Mark J Taylor
    Filariasis Research Group, Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Liverpool, UK
    Lancet 365:2116-21. 2005
    ..We used this strategy to investigate the effects of doxycycline treatment on the major cause of lymphatic filariasis, Wuchereria bancrofti...
  72. ncbi request reprint The major surface protein of Wolbachia endosymbionts in filarial nematodes elicits immune responses through TLR2 and TLR4
    Norbert W Brattig
    Tropical Medicine Section, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, D 20359 Hamburg, Germany
    J Immunol 173:437-45. 2004
    ..Thus, filarial helminths, through products of their endobacteria such as WSP, acquire characteristics of a typical microbial pathogen inducing immune responses via TLR2 and TLR4...
  73. ncbi request reprint Increased early local immune responses and altered worm development in high-dose infections of mice susceptible to the filaria Litomosoides sigmodontis
    Simon Babayan
    Parasitologie Comparée et Modèles expérimentaux associé à INSERM U567 et Ecole Pratique des Hautes Etudes, Museum national d histoire naturelle, 61 rue Buffon, 75213, Paris Cedex 05, France
    Med Microbiol Immunol 194:151-62. 2005
    ..This suggests that the very early events determine subsequent immune response and infection outcome rather than competitive interactions between the worms...
  74. ncbi request reprint Newbouldiaquinone A: A naphthoquinone-anthraquinone ether coupled pigment, as a potential antimicrobial and antimalarial agent from Newbouldia laevis
    Kenneth Oben Eyong
    Department of Organic Chemistry, Yaounde University I, P O Box 812, Yaounde, Cameroon
    Phytochemistry 67:605-9. 2006
    ..Its antimicrobial activity against a wide range of microorganisms was 13- and 24-fold more active against Candida gabrata and Enterobacter aerogens than the reference antibiotics nystatin and gentamycin...
  75. ncbi request reprint More research needed to consolidate achievements in filariasis control
    Achim Hoerauf
    Bernhard Nocht Institute of Tropical Medicine, 20359 Hamburg, Germany
    Med Microbiol Immunol 192:1-2. 2003
  76. ncbi request reprint The variant Arg110Gln of human IL-13 is associated with an immunologically hyper-reactive form of onchocerciasis (sowda)
    Achim Hoerauf
    Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany
    Microbes Infect 4:37-42. 2002
    ..Arg110Gln has been suggested to lead to enhanced IL-13 signaling and thus may be involved in shifting the immune reaction towards the hyper-reactivity characteristic for the sowda form, thereby promoting defense mechanisms...
  77. ncbi request reprint Expansion of NK cells with reduction of their inhibitory Ly-49A, Ly-49C, and Ly-49G2 receptor-expressing subsets in a murine helminth infection: contribution to parasite control
    Simone Korten
    Department of Medical Microbiology and Immunology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
    J Immunol 168:5199-206. 2002
    ..These data demonstrate a new role for NK cells in the host defense against filariae and, for the first time, alterations of Ly-49 receptor-expressing NK cell subsets in a parasitic infection...
  78. pmc On the taxonomic status of the intracellular bacterium Wolbachia pipientis: should this species name include the intracellular bacteria of filarial nematodes?
    Kenneth Pfarr
    Int J Syst Evol Microbiol 57:1677-8. 2007