Carsten Hocke

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. doi request reprint Biodistribution studies of two (18)F-labeled pyridinylphenyl amides as subtype selective radioligands for the dopamine D3 receptor
    Carsten Hocke
    Molecular Imaging and Radiochemistry, Nuclear Medicine Clinic, Friedrich Alexander University, Schwabachanlage 6, D 91054 Erlangen, Germany Electronic address
    Nucl Med Biol 41:223-8. 2014
  2. doi request reprint A series of 18F-labelled pyridinylphenyl amides as subtype-selective radioligands for the dopamine D3 receptor
    Carsten Hocke
    Friedrich Alexander University Erlangen Nurnberg, Clinic of Nuclear Medicine, Friedrich Alexander University, Krankenhausstrasse 12, 91054 Erlangen, Germany
    ChemMedChem 5:941-8. 2010
  3. ncbi request reprint Structure-selectivity investigations of D2-like receptor ligands by CoMFA and CoMSIA guiding the discovery of D3 selective PET radioligands
    Ismail Salama
    Department of Medicinal Chemistry, Emil Fischer Center, Friedrich Alexander University, Schuhstrasse 19, D 91052 Erlangen, Germany
    J Med Chem 50:489-500. 2007
  4. doi request reprint 18F-Labeled FAUC 346 and BP 897 derivatives as subtype-selective potential PET radioligands for the dopamine D3 receptor
    Carsten Hocke
    Clinic of Nuclear Medicine, Friedrich Alexander University, Krankenhausstrasse 12, 91054 Erlangen, Germany
    ChemMedChem 3:788-93. 2008
  5. doi request reprint Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET
    Olaf Prante
    Laboratory of Molecular Imaging, Clinic of Nuclear Medicine, Friedrich Alexander University, Erlangen, Germany
    J Med Chem 51:1800-10. 2008
  6. ncbi request reprint Synthesis and evaluation of 18F-labeled dopamine D3 receptor ligands as potential PET imaging agents
    Carsten Hocke
    Department of Nuclear Medicine, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Bioorg Med Chem Lett 15:4819-23. 2005
  7. ncbi request reprint Synthesis and radioiodination of selective ligands for the dopamine D3 receptor subtype
    Carsten Hocke
    Department of Nuclear Medicine, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Bioorg Med Chem Lett 14:3963-6. 2004
  8. ncbi request reprint Characterization of uptake of 3-[(131)I]iodo-alpha-methyl-L-tyrosine in human monocyte-macrophages
    Olaf Prante
    Department of Nuclear Medicine, Laboratory of Molecular Imaging, Friedrich Alexander University, Erlangen, Germany
    Nucl Med Biol 31:365-72. 2004

Collaborators

Detail Information

Publications8

  1. doi request reprint Biodistribution studies of two (18)F-labeled pyridinylphenyl amides as subtype selective radioligands for the dopamine D3 receptor
    Carsten Hocke
    Molecular Imaging and Radiochemistry, Nuclear Medicine Clinic, Friedrich Alexander University, Schwabachanlage 6, D 91054 Erlangen, Germany Electronic address
    Nucl Med Biol 41:223-8. 2014
    ..We evaluated two in vitro selective fluorine-18-labeled radioligand candidates ([(18)F]5 and [(18)F]6) for positron emission tomography (PET) imaging of D3 receptor availability in the brain...
  2. doi request reprint A series of 18F-labelled pyridinylphenyl amides as subtype-selective radioligands for the dopamine D3 receptor
    Carsten Hocke
    Friedrich Alexander University Erlangen Nurnberg, Clinic of Nuclear Medicine, Friedrich Alexander University, Krankenhausstrasse 12, 91054 Erlangen, Germany
    ChemMedChem 5:941-8. 2010
    ....
  3. ncbi request reprint Structure-selectivity investigations of D2-like receptor ligands by CoMFA and CoMSIA guiding the discovery of D3 selective PET radioligands
    Ismail Salama
    Department of Medicinal Chemistry, Emil Fischer Center, Friedrich Alexander University, Schuhstrasse 19, D 91052 Erlangen, Germany
    J Med Chem 50:489-500. 2007
    ....
  4. doi request reprint 18F-Labeled FAUC 346 and BP 897 derivatives as subtype-selective potential PET radioligands for the dopamine D3 receptor
    Carsten Hocke
    Clinic of Nuclear Medicine, Friedrich Alexander University, Krankenhausstrasse 12, 91054 Erlangen, Germany
    ChemMedChem 3:788-93. 2008
    ..Optimization of the (18)F-labeling conditions led to radiochemical yields between 24 and 65 %...
  5. doi request reprint Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET
    Olaf Prante
    Laboratory of Molecular Imaging, Clinic of Nuclear Medicine, Friedrich Alexander University, Erlangen, Germany
    J Med Chem 51:1800-10. 2008
    ..The observed binding pattern was mainly consistent with the known D 4R distribution in the rat brain. Thus, [(18)F]3h (FAUC F41) represents a potential radioligand for studying the D 4R in vivo by positron emission tomography (PET)...
  6. ncbi request reprint Synthesis and evaluation of 18F-labeled dopamine D3 receptor ligands as potential PET imaging agents
    Carsten Hocke
    Department of Nuclear Medicine, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Bioorg Med Chem Lett 15:4819-23. 2005
    ..The most promising ligand, [18F]8d, was used as imaging agent of the D3 receptor in vitro. However, due to the lack of specific binding, further studies should aim at the development of radioligands with improved D3 receptor selectivity...
  7. ncbi request reprint Synthesis and radioiodination of selective ligands for the dopamine D3 receptor subtype
    Carsten Hocke
    Department of Nuclear Medicine, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Bioorg Med Chem Lett 14:3963-6. 2004
    ..Suitable precursors were radioiodinated with high radiochemical yields (53-85%) leading to potential imaging agents for the D3 receptor by SPET...
  8. ncbi request reprint Characterization of uptake of 3-[(131)I]iodo-alpha-methyl-L-tyrosine in human monocyte-macrophages
    Olaf Prante
    Department of Nuclear Medicine, Laboratory of Molecular Imaging, Friedrich Alexander University, Erlangen, Germany
    Nucl Med Biol 31:365-72. 2004
    ....