Research Topics
Genomes and Genes
| Klaus HocherlSummaryAffiliation: University of Regensburg Country: Germany Publications
| Collaborators
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Detail Information
Publications
Effect of tropisetron on circulating catecholamines and other putative biochemical markers in serum of patients with fibromyalgiaK Hocherl
Department of Pharmacology and Clinical Pharmacology, University of Regensburg, Germany
Scand J Rheumatol Suppl 113:46-8. 2000..Moreover, serum concentrations of serotonin, somatomedin C, oxytocin, calcitonin-gene-related-peptide, calcitonin and cholecystokinin were assayed as putative markers in pain-related disorders like primary fibromyalgia...
Activation of the PGI(2)/IP system contributes to the development of circulatory failure in a rat model of endotoxic shockKlaus Hocherl
Universitat Regensburg, Institut fur Physiologie, Universitätsstr 31, D 93040 Regensburg, Germany
Hypertension 52:330-5. 2008..Taken together, our data demonstrate a prominent role of the prostacyclin/IP system in the development of LPS-induced cardiovascular failure...- Inhibition of NF-kappaB ameliorates sepsis-induced downregulation of aquaporin-2/V2 receptor expression and acute renal failure in vivoKlaus Hocherl
Institut fur Physiologie, Universitat Regensburg, Universitätsstr 31, D 93040 Regensburg, Germany
Am J Physiol Renal Physiol 298:F196-204. 2010..In addition, our data indicate that NF-kappaB inhibition ameliorates sepsis-induced ARF... - Proteinase-activated receptors 1 and 2 exert opposite effects on renal renin releaseKlaus Hocherl
Institute of Physiology, University of Regensburg, Regensburg, Germany
Hypertension 58:611-8. 2011..Our data provide evidence that PAR1 activation inhibits renal renin secretion and induces renal vasoconstriction, whereas PAR2 activation stimulates renin release and induces vasodilation mainly via the release of NO... 
Everolimus treatment downregulates renocortical cyclooxygenase-2 expression in the rat kidneyKlaus Hocherl
Institut fur Pharmazie, Lehrstuhl für Pharmakologie und Toxikologie, Universitat Regensburg, Universitatsstrasse 31, D 93040 Regensburg, Germany
Br J Pharmacol 145:1112-22. 2005..Since inhibition of renal prostanoid formation by everolimus was associated by an increased rather than decreased natriuresis and diuresis, it appears as if everolimus also inhibits tubular salt and water resorption...- Cyclosporine A attenuates the natriuretic action of loop diuretics by inhibition of renal COX-2 expressionKlaus Hocherl
Institut fur Pharmakologie, Innere Medizin II and Physiologie, Universitat Regensburg, Regensburg, Germany
Kidney Int 65:2071-80. 2004..Recently, we found that cyclosporine A (CsA) inhibits renal COX-2 expression. Therefore, we examined the interferences of CsA with the renal actions of loop diuretics... - COX-2 inhibition attenuates endotoxin-induced downregulation of organic anion transporters in the rat renal cortexKlaus Hocherl
Institut fur Physiologie, Universitat Regensburg, Regensburg, Germany
Kidney Int 75:373-80. 2009..Our findings show that COX-2 derived prostanoids downregulate OATs during lipopolysaccharide-induced acute renal injury... - Cyclosporine A suppresses cyclooxygenase-2 expression in the rat kidneyKlaus Hocherl
Institut fur Pharmakologie, University of Regensburg, Regensburg, Germany
J Am Soc Nephrol 13:2427-36. 2002..Moreover, our data suggest that the stimulation of the renin system by low salt and by ACE inhibitors is not essentially mediated by COX-2 activity... - Cyclo-oxygenase-2 inhibition increases blood pressure in ratsKlaus Hocherl
Institut fur Pharmakologie, Universitätsstr 31, 93040 Regensburg, Germany
Br J Pharmacol 136:1117-26. 2002..Similarly, an activation of the renin-angiotensin-aldosterone axis appears to be an unlikely candidate mechanism... - Role of prostanoids in regulation of the renin-angiotensin-aldosterone system by salt intakeKlaus Hocherl
Institut fur Pharmakologie, der Universität Regensburg, D 93040 Regensburg, Germany
Am J Physiol Renal Physiol 283:F294-301. 2002..These findings suggest that COX-1-derived, but not COX-2-derived, prostanoids are of relevance for the regulation of the renin system by salt intake... - Renocortical expression of renin and of cyclooxygenase-2 in response to angiotensin II AT1 receptor blockade is closely coordinated but not causally linkedK Hocherl
Institut für Pharmakologie der Universität Regensburg, Germany
Pflugers Arch 442:821-7. 2001.... - Role of renal nerves in stimulation of renin, COX-2, and nNOS in rat renal cortex during salt deficiencyK Hocherl
Department of Pharmacology, University of Regensburg, 93040 Regensburg, Germany
Am J Physiol Renal Physiol 282:F478-84. 2002..However, beta-adrenoreceptor activity or renal nerve activity appears to be required for the full stimulation of nNOS expression by low salt intake or combined with angiotensin-converting enzyme inhibition... - Cyclooxygenase-2 inhibition attenuates lipopolysaccharide-induced cardiovascular failureKlaus Hocherl
Department of Pharmacology, University of Regensburg, Regensburg, Germany
Hypertension 40:947-53. 2002..Taken together, our data suggest that COX-2-derived prostanoids are major mediators for the detrimental effects of LPS on cardiovascular and organ function... - Inhibition of NF-kappaB activity prevents downregulation of alpha1-adrenergic receptors and circulatory failure during CLP-induced sepsisChristoph Schmidt
Department of Anesthesiology, University of Regensburg, Franz Josef Strauss, Regensburg, Germany
Shock 32:239-46. 2009..Our data further define a critical role for NF-kappaB in the pathogenesis of septic shock, indicating that targeting NF-kappaB is a desired therapeutic strategy to treat septic vasoplegia... - Blockade of multiple but not single cytokines abrogates downregulation of angiotensin II type-I receptors and anticipates septic shockChristoph Schmidt
Department of Anesthesiology, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
Cytokine 49:30-8. 2010..Our data demonstrate that downregulation of AT(1)-receptors during sepsis is due to multiple but not single cytokines and define a relevant role for NF-kappaB in the pathogenesis of septic shock... - COX-2 activity determines the level of renin expression but is dispensable for acute upregulation of renin expression in rat kidneysCorina Matzdorf
Institute für Pharmakologie, Universitat Regensburg, Regensburg, Germany
Am J Physiol Renal Physiol 292:F1782-90. 2007..As a consequence, it appears as if COX-2 activity relevantly determines the set point of the activity of the renin system in rat kidneys... - Role of nuclear factor-kappaB-dependent induction of cytokines in the regulation of vasopressin V1A-receptors during cecal ligation and puncture-induced circulatory failureChristoph Schmidt
Department of Anesthesiology, Regensburg University, Regensburg, Germany
Crit Care Med 36:2363-72. 2008..Here we characterize the impact of nuclear factor-kappaB and cytokines on cecal ligation and puncture-induced circulatory failure and regulation of vasopressin V1A-receptors during inflammation... - Proinflammatory cytokines cause down-regulation of renal chloride entry pathways during sepsisChristoph Schmidt
Department of Anesthesiology, Regensburg University, Regensburg, Germany
Crit Care Med 35:2110-9. 2007.... - Cytokine-mediated regulation of urea transporters during experimental endotoxemiaChristoph Schmidt
Departments of Anesthesiology, Regensburg University, Regensburg, Germany
Am J Physiol Renal Physiol 292:F1479-89. 2007..Furthermore, they suggest that the downregulation of renal urea transporters during LPS-induced ARF is mediated by proinflammatory cytokines and is independent from renal ischemia because of sepsis-induced hypotension... - In vivo efficacy of telithromycin on cytokine and nitric oxide formation in lipopolysaccharide-induced acute systemic inflammation in miceKristina Lotter
Department of Pharmacology und Toxicology, University of Regensburg Universitätsstr, Regensburg, Germany
J Antimicrob Chemother 58:615-21. 2006.... - Increased expression of cyclooxygenase 2 contributes to aberrant renin production in connexin 40-deficient kidneysCharlotte Wagner
Institute of Physiology, University of Regensburg, Regensburg, Germany
Am J Physiol Regul Integr Comp Physiol 293:R1781-6. 2007..Apparently, these disseminated cells do not contribute to the enhanced renin secretion rates of Cx40-deficient kidneys... - Physiology of kidney reninHayo Castrop
Institute of Physiology, University of Regensburg, Regensburg, Germany
Physiol Rev 90:607-73. 2010..The broad spectrum of biological actions of (pro)renin is mediated by receptors for (pro)renin, angiotensin II and angiotensin-(1-7)... - IRAG determines nitric oxide- and atrial natriuretic peptide-mediated smooth muscle relaxationMatthias Desch
Pharmakologie und Toxikologie, Universitat Regensburg, Universitätstr 31, D 93055 Regensburg, Germany
Cardiovasc Res 86:496-505. 2010..To elucidate the role of IRAG for NO- and ANP-mediated smooth muscle tone regulation, cGKI localization, and for its possible function in blood pressure adjustment, we generated IRAG-knockout mice by targeted deletion of exon 3... - Acute endotoxemia in mice induces downregulation of megalin and cubilin in the kidneyAndrea Schreiber
Institute of Physiology, University of Regensburg, Regensburg, Germany
Kidney Int 82:53-9. 2012..This downregulation may contribute, in part, to an increase in urine levels of albumin during acute renal failure... - Characterization of mouse heart adenylyl cyclaseMartin Göttle
Department of Pharmacology and Toxicology, University of Regensburg, Regensburg, Germany
J Pharmacol Exp Ther 329:1156-65. 2009..Moreover, lack of antibody specificity and Mn(2+) masking AC5 effects were problems... - Angiotensin AT1 receptor-associated protein Arap1 in the kidney vasculature is suppressed by angiotensin IIElisabeth Doblinger
Institute of Physiology, Univ of Regensburg, Universitätsstr 31, 93040 Regensburg, Germany
Am J Physiol Renal Physiol 302:F1313-24. 2012..In summary, Arap1 is highly expressed in the renal vasculature, and its expression is suppressed by angiotensin II. Thus Arap1 may serve as a local modulator of vascular AT(1) receptor function in vivo...