Klaus Hocherl

Summary

Affiliation: University of Regensburg
Country: Germany

Publications

  1. ncbi request reprint Effect of tropisetron on circulating catecholamines and other putative biochemical markers in serum of patients with fibromyalgia
    K Hocherl
    Department of Pharmacology and Clinical Pharmacology, University of Regensburg, Germany
    Scand J Rheumatol Suppl 113:46-8. 2000
  2. doi request reprint Activation of the PGI(2)/IP system contributes to the development of circulatory failure in a rat model of endotoxic shock
    Klaus Hocherl
    Universitat Regensburg, Institut fur Physiologie, Universitätsstr 31, D 93040 Regensburg, Germany
    Hypertension 52:330-5. 2008
  3. doi request reprint Inhibition of NF-kappaB ameliorates sepsis-induced downregulation of aquaporin-2/V2 receptor expression and acute renal failure in vivo
    Klaus Hocherl
    Institut fur Physiologie, Universitat Regensburg, Universitätsstr 31, D 93040 Regensburg, Germany
    Am J Physiol Renal Physiol 298:F196-204. 2010
  4. doi request reprint Proteinase-activated receptors 1 and 2 exert opposite effects on renal renin release
    Klaus Hocherl
    Institute of Physiology, University of Regensburg, Regensburg, Germany
    Hypertension 58:611-8. 2011
  5. pmc Everolimus treatment downregulates renocortical cyclooxygenase-2 expression in the rat kidney
    Klaus Hocherl
    Institut fur Pharmazie, Lehrstuhl für Pharmakologie und Toxikologie, Universitat Regensburg, Universitatsstrasse 31, D 93040 Regensburg, Germany
    Br J Pharmacol 145:1112-22. 2005
  6. ncbi request reprint Cyclosporine A attenuates the natriuretic action of loop diuretics by inhibition of renal COX-2 expression
    Klaus Hocherl
    Institut fur Pharmakologie, Innere Medizin II and Physiologie, Universitat Regensburg, Regensburg, Germany
    Kidney Int 65:2071-80. 2004
  7. doi request reprint COX-2 inhibition attenuates endotoxin-induced downregulation of organic anion transporters in the rat renal cortex
    Klaus Hocherl
    Institut fur Physiologie, Universitat Regensburg, Regensburg, Germany
    Kidney Int 75:373-80. 2009
  8. ncbi request reprint Cyclosporine A suppresses cyclooxygenase-2 expression in the rat kidney
    Klaus Hocherl
    Institut fur Pharmakologie, University of Regensburg, Regensburg, Germany
    J Am Soc Nephrol 13:2427-36. 2002
  9. pmc Cyclo-oxygenase-2 inhibition increases blood pressure in rats
    Klaus Hocherl
    Institut fur Pharmakologie, Universitätsstr 31, 93040 Regensburg, Germany
    Br J Pharmacol 136:1117-26. 2002
  10. ncbi request reprint Role of prostanoids in regulation of the renin-angiotensin-aldosterone system by salt intake
    Klaus Hocherl
    Institut fur Pharmakologie, der Universität Regensburg, D 93040 Regensburg, Germany
    Am J Physiol Renal Physiol 283:F294-301. 2002

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Effect of tropisetron on circulating catecholamines and other putative biochemical markers in serum of patients with fibromyalgia
    K Hocherl
    Department of Pharmacology and Clinical Pharmacology, University of Regensburg, Germany
    Scand J Rheumatol Suppl 113:46-8. 2000
    ..Moreover, serum concentrations of serotonin, somatomedin C, oxytocin, calcitonin-gene-related-peptide, calcitonin and cholecystokinin were assayed as putative markers in pain-related disorders like primary fibromyalgia...
  2. doi request reprint Activation of the PGI(2)/IP system contributes to the development of circulatory failure in a rat model of endotoxic shock
    Klaus Hocherl
    Universitat Regensburg, Institut fur Physiologie, Universitätsstr 31, D 93040 Regensburg, Germany
    Hypertension 52:330-5. 2008
    ..Taken together, our data demonstrate a prominent role of the prostacyclin/IP system in the development of LPS-induced cardiovascular failure...
  3. doi request reprint Inhibition of NF-kappaB ameliorates sepsis-induced downregulation of aquaporin-2/V2 receptor expression and acute renal failure in vivo
    Klaus Hocherl
    Institut fur Physiologie, Universitat Regensburg, Universitätsstr 31, D 93040 Regensburg, Germany
    Am J Physiol Renal Physiol 298:F196-204. 2010
    ..In addition, our data indicate that NF-kappaB inhibition ameliorates sepsis-induced ARF...
  4. doi request reprint Proteinase-activated receptors 1 and 2 exert opposite effects on renal renin release
    Klaus Hocherl
    Institute of Physiology, University of Regensburg, Regensburg, Germany
    Hypertension 58:611-8. 2011
    ..Our data provide evidence that PAR1 activation inhibits renal renin secretion and induces renal vasoconstriction, whereas PAR2 activation stimulates renin release and induces vasodilation mainly via the release of NO...
  5. pmc Everolimus treatment downregulates renocortical cyclooxygenase-2 expression in the rat kidney
    Klaus Hocherl
    Institut fur Pharmazie, Lehrstuhl für Pharmakologie und Toxikologie, Universitat Regensburg, Universitatsstrasse 31, D 93040 Regensburg, Germany
    Br J Pharmacol 145:1112-22. 2005
    ..Since inhibition of renal prostanoid formation by everolimus was associated by an increased rather than decreased natriuresis and diuresis, it appears as if everolimus also inhibits tubular salt and water resorption...
  6. ncbi request reprint Cyclosporine A attenuates the natriuretic action of loop diuretics by inhibition of renal COX-2 expression
    Klaus Hocherl
    Institut fur Pharmakologie, Innere Medizin II and Physiologie, Universitat Regensburg, Regensburg, Germany
    Kidney Int 65:2071-80. 2004
    ..Recently, we found that cyclosporine A (CsA) inhibits renal COX-2 expression. Therefore, we examined the interferences of CsA with the renal actions of loop diuretics...
  7. doi request reprint COX-2 inhibition attenuates endotoxin-induced downregulation of organic anion transporters in the rat renal cortex
    Klaus Hocherl
    Institut fur Physiologie, Universitat Regensburg, Regensburg, Germany
    Kidney Int 75:373-80. 2009
    ..Our findings show that COX-2 derived prostanoids downregulate OATs during lipopolysaccharide-induced acute renal injury...
  8. ncbi request reprint Cyclosporine A suppresses cyclooxygenase-2 expression in the rat kidney
    Klaus Hocherl
    Institut fur Pharmakologie, University of Regensburg, Regensburg, Germany
    J Am Soc Nephrol 13:2427-36. 2002
    ..Moreover, our data suggest that the stimulation of the renin system by low salt and by ACE inhibitors is not essentially mediated by COX-2 activity...
  9. pmc Cyclo-oxygenase-2 inhibition increases blood pressure in rats
    Klaus Hocherl
    Institut fur Pharmakologie, Universitätsstr 31, 93040 Regensburg, Germany
    Br J Pharmacol 136:1117-26. 2002
    ..Similarly, an activation of the renin-angiotensin-aldosterone axis appears to be an unlikely candidate mechanism...
  10. ncbi request reprint Role of prostanoids in regulation of the renin-angiotensin-aldosterone system by salt intake
    Klaus Hocherl
    Institut fur Pharmakologie, der Universität Regensburg, D 93040 Regensburg, Germany
    Am J Physiol Renal Physiol 283:F294-301. 2002
    ..These findings suggest that COX-1-derived, but not COX-2-derived, prostanoids are of relevance for the regulation of the renin system by salt intake...
  11. ncbi request reprint Renocortical expression of renin and of cyclooxygenase-2 in response to angiotensin II AT1 receptor blockade is closely coordinated but not causally linked
    K Hocherl
    Institut für Pharmakologie der Universität Regensburg, Germany
    Pflugers Arch 442:821-7. 2001
    ....
  12. ncbi request reprint Role of renal nerves in stimulation of renin, COX-2, and nNOS in rat renal cortex during salt deficiency
    K Hocherl
    Department of Pharmacology, University of Regensburg, 93040 Regensburg, Germany
    Am J Physiol Renal Physiol 282:F478-84. 2002
    ..However, beta-adrenoreceptor activity or renal nerve activity appears to be required for the full stimulation of nNOS expression by low salt intake or combined with angiotensin-converting enzyme inhibition...
  13. ncbi request reprint Cyclooxygenase-2 inhibition attenuates lipopolysaccharide-induced cardiovascular failure
    Klaus Hocherl
    Department of Pharmacology, University of Regensburg, Regensburg, Germany
    Hypertension 40:947-53. 2002
    ..Taken together, our data suggest that COX-2-derived prostanoids are major mediators for the detrimental effects of LPS on cardiovascular and organ function...
  14. doi request reprint Inhibition of NF-kappaB activity prevents downregulation of alpha1-adrenergic receptors and circulatory failure during CLP-induced sepsis
    Christoph Schmidt
    Department of Anesthesiology, University of Regensburg, Franz Josef Strauss, Regensburg, Germany
    Shock 32:239-46. 2009
    ..Our data further define a critical role for NF-kappaB in the pathogenesis of septic shock, indicating that targeting NF-kappaB is a desired therapeutic strategy to treat septic vasoplegia...
  15. doi request reprint Blockade of multiple but not single cytokines abrogates downregulation of angiotensin II type-I receptors and anticipates septic shock
    Christoph Schmidt
    Department of Anesthesiology, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Cytokine 49:30-8. 2010
    ..Our data demonstrate that downregulation of AT(1)-receptors during sepsis is due to multiple but not single cytokines and define a relevant role for NF-kappaB in the pathogenesis of septic shock...
  16. ncbi request reprint COX-2 activity determines the level of renin expression but is dispensable for acute upregulation of renin expression in rat kidneys
    Corina Matzdorf
    Institute für Pharmakologie, Universitat Regensburg, Regensburg, Germany
    Am J Physiol Renal Physiol 292:F1782-90. 2007
    ..As a consequence, it appears as if COX-2 activity relevantly determines the set point of the activity of the renin system in rat kidneys...
  17. doi request reprint Role of nuclear factor-kappaB-dependent induction of cytokines in the regulation of vasopressin V1A-receptors during cecal ligation and puncture-induced circulatory failure
    Christoph Schmidt
    Department of Anesthesiology, Regensburg University, Regensburg, Germany
    Crit Care Med 36:2363-72. 2008
    ..Here we characterize the impact of nuclear factor-kappaB and cytokines on cecal ligation and puncture-induced circulatory failure and regulation of vasopressin V1A-receptors during inflammation...
  18. ncbi request reprint Proinflammatory cytokines cause down-regulation of renal chloride entry pathways during sepsis
    Christoph Schmidt
    Department of Anesthesiology, Regensburg University, Regensburg, Germany
    Crit Care Med 35:2110-9. 2007
    ....
  19. ncbi request reprint Cytokine-mediated regulation of urea transporters during experimental endotoxemia
    Christoph Schmidt
    Departments of Anesthesiology, Regensburg University, Regensburg, Germany
    Am J Physiol Renal Physiol 292:F1479-89. 2007
    ..Furthermore, they suggest that the downregulation of renal urea transporters during LPS-induced ARF is mediated by proinflammatory cytokines and is independent from renal ischemia because of sepsis-induced hypotension...
  20. ncbi request reprint In vivo efficacy of telithromycin on cytokine and nitric oxide formation in lipopolysaccharide-induced acute systemic inflammation in mice
    Kristina Lotter
    Department of Pharmacology und Toxicology, University of Regensburg Universitätsstr, Regensburg, Germany
    J Antimicrob Chemother 58:615-21. 2006
    ....
  21. ncbi request reprint Increased expression of cyclooxygenase 2 contributes to aberrant renin production in connexin 40-deficient kidneys
    Charlotte Wagner
    Institute of Physiology, University of Regensburg, Regensburg, Germany
    Am J Physiol Regul Integr Comp Physiol 293:R1781-6. 2007
    ..Apparently, these disseminated cells do not contribute to the enhanced renin secretion rates of Cx40-deficient kidneys...
  22. doi request reprint Physiology of kidney renin
    Hayo Castrop
    Institute of Physiology, University of Regensburg, Regensburg, Germany
    Physiol Rev 90:607-73. 2010
    ..The broad spectrum of biological actions of (pro)renin is mediated by receptors for (pro)renin, angiotensin II and angiotensin-(1-7)...
  23. doi request reprint IRAG determines nitric oxide- and atrial natriuretic peptide-mediated smooth muscle relaxation
    Matthias Desch
    Pharmakologie und Toxikologie, Universitat Regensburg, Universitätstr 31, D 93055 Regensburg, Germany
    Cardiovasc Res 86:496-505. 2010
    ..To elucidate the role of IRAG for NO- and ANP-mediated smooth muscle tone regulation, cGKI localization, and for its possible function in blood pressure adjustment, we generated IRAG-knockout mice by targeted deletion of exon 3...
  24. doi request reprint Acute endotoxemia in mice induces downregulation of megalin and cubilin in the kidney
    Andrea Schreiber
    Institute of Physiology, University of Regensburg, Regensburg, Germany
    Kidney Int 82:53-9. 2012
    ..This downregulation may contribute, in part, to an increase in urine levels of albumin during acute renal failure...
  25. doi request reprint Characterization of mouse heart adenylyl cyclase
    Martin Göttle
    Department of Pharmacology and Toxicology, University of Regensburg, Regensburg, Germany
    J Pharmacol Exp Ther 329:1156-65. 2009
    ..Moreover, lack of antibody specificity and Mn(2+) masking AC5 effects were problems...
  26. doi request reprint Angiotensin AT1 receptor-associated protein Arap1 in the kidney vasculature is suppressed by angiotensin II
    Elisabeth Doblinger
    Institute of Physiology, Univ of Regensburg, Universitätsstr 31, 93040 Regensburg, Germany
    Am J Physiol Renal Physiol 302:F1313-24. 2012
    ..In summary, Arap1 is highly expressed in the renal vasculature, and its expression is suppressed by angiotensin II. Thus Arap1 may serve as a local modulator of vascular AT(1) receptor function in vivo...