- Hocherl K, Schmidt C, Kurt B, Bucher M. Activation of the PGI(2)/IP system contributes to the development of circulatory failure in a rat model of endotoxic shock. Hypertension. 2008;52:330-5 pubmed publisher..Taken together, our data demonstrate a prominent role of the prostacyclin/IP system in the development of LPS-induced cardiovascular failure. ..
- Hocherl K, Schmidt C, Bucher M. COX-2 inhibition attenuates endotoxin-induced downregulation of organic anion transporters in the rat renal cortex. Kidney Int. 2009;75:373-80 pubmed publisher..Our findings show that COX-2 derived prostanoids downregulate OATs during lipopolysaccharide-induced acute renal injury. ..
- Hocherl K, Schmidt C, Kurt B, Bucher M. Inhibition of NF-kappaB ameliorates sepsis-induced downregulation of aquaporin-2/V2 receptor expression and acute renal failure in vivo. Am J Physiol Renal Physiol. 2010;298:F196-204 pubmed publisher..In addition, our data indicate that NF-kappaB inhibition ameliorates sepsis-induced ARF. ..
- Hocherl K, Gerl M, Schweda F. Proteinase-activated receptors 1 and 2 exert opposite effects on renal renin release. Hypertension. 2011;58:611-8 pubmed publisher..Our data provide evidence that PAR1 activation inhibits renal renin secretion and induces renal vasoconstriction, whereas PAR2 activation stimulates renin release and induces vasodilation mainly via the release of NO. ..