Affiliation: University of Bonn
Sellin J, Schulze H, Paradis M, Gosejacob D, Papan C, Shevchenko A, et al
. Characterization of Drosophila Saposin-related mutants as a model for lysosomal sphingolipid storage diseases. Dis Model Mech. 2017;10:737-750 pubmed publisher
Mass E, Wachten D, Aschenbrenner A, Voelzmann A, Hoch M. Murine Creld1 controls cardiac development through activation of calcineurin/NFATc1 signaling. Dev Cell. 2014;28:711-26 pubmed publisher
..Collectively, our study identifies Creld1 as an important regulator of calcineurin/NFATc1 signaling. ..
Wakabayashi S, Sawamura N, Voelzmann A, Broemer M, Asahi T, Hoch M. Ohgata, the Single Drosophila Ortholog of Human Cereblon, Regulates Insulin Signaling-dependent Organismic Growth. J Biol Chem. 2016;291:25120-25132 pubmed
..The two inhibitory proteins were previously shown to be components of a heterotrimeric complex with growth-promoting DILP2 and DILP5. Our study reveals OHGT as a novel regulator of insulin-dependent organismic growth in Drosophila. ..
Richard M, Bauer R, Tavosanis G, Hoch M. The gap junction protein Innexin3 is required for eye disc growth in Drosophila. Dev Biol. 2017;425:191-207 pubmed publisher
..Our data provide a functional demonstration that putative Inx2/Inx3 heteromeric channels regulate organ size. ..
Wingen A, Carrera P, Ekaterini Psathaki O, Voelzmann A, Paululat A, Hoch M. Debris buster is a Drosophila scavenger receptor essential for airway physiology. Dev Biol. 2017;430:52-68 pubmed publisher
..Our data provide insights into a spatially confined function of the SR-B Dsb in intracellular trafficking critical for the physiology of the whole tubular airway network. ..
Varma D, Bülow M, Pesch Y, Loch G, Hoch M. Forkhead, a new cross regulator of metabolism and innate immunity downstream of TOR in Drosophila. J Insect Physiol. 2014;69:80-8 pubmed publisher
Richard M, Hoch M. Drosophila eye size is determined by Innexin 2-dependent Decapentaplegic signalling. Dev Biol. 2015;408:26-40 pubmed publisher
..We further show that inx2 is required for the transcriptional activation of dpp and punt in the eye disc. Our results highlight the crucial role of gap junction proteins in regulating morphogen-dependent organ size determination. ..
Gosejacob D, JÃ¤ger P, Vom Dorp K, Frejno M, Carstensen A, KÃ¶hnke M, et al
. Ceramide Synthase 5 Is Essential to Maintain C16:0-Ceramide Pools and Contributes to the Development of Diet-induced Obesity. J Biol Chem. 2016;291:6989-7003 pubmed publisher
..Our findings indicate that reduction of endogenous C16:0-ceramide by genetic inhibition ofCerS5is sufficient to ameliorate obesity and its comorbidities. ..
Moessinger C, Klizaite K, Steinhagen A, Philippou Massier J, Shevchenko A, Hoch M, et al
. Two different pathways of phosphatidylcholine synthesis, the Kennedy Pathway and the Lands Cycle, differentially regulate cellular triacylglycerol storage. BMC Cell Biol. 2014;15:43 pubmed publisher
..Differences in lipid droplet size may account for differences in lipid dynamics and be relevant to understand lipid overload diseases. ..