Burkhard Hinz

Summary

Affiliation: University of Rostock
Country: Germany

Publications

  1. doi request reprint Paracetamol and cyclooxygenase inhibition: is there a cause for concern?
    Burkhard Hinz
    Institute of Toxicology and Pharmacology, University of Rostock, Schillingallee 70, D 18057 Rostock, Germany
    Ann Rheum Dis 71:20-5. 2012
  2. ncbi request reprint Drug insight: cyclo-oxygenase-2 inhibitors--a critical appraisal
    Burkhard Hinz
    Institute of Toxicology and Pharmacology, University of Rostock, Germany
    Nat Clin Pract Rheumatol 3:552-60; quiz 1 p following 589. 2007
  3. ncbi request reprint Impact of naproxen sodium at over-the-counter doses on cyclooxygenase isoforms in human volunteers
    B Hinz
    Institute of Toxicology and Pharmacology, University of Rostock, Schillingallee 70, Rostock, Germany
    Int J Clin Pharmacol Ther 46:180-6. 2008
  4. ncbi request reprint Can drug removals involving cyclooxygenase-2 inhibitors be avoided? A plea for human pharmacology
    Burkhard Hinz
    Institute of Toxicology and Pharmacology, University of Rostock, Schillingallee 70, 18057 Rostock, Germany
    Trends Pharmacol Sci 29:391-7. 2008
  5. ncbi request reprint Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man
    Burkhard Hinz
    Institute of Toxicology and Pharmacology, University of Rostock, Schillingallee 70, D 18057 Rostock, Germany
    FASEB J 22:383-90. 2008
  6. ncbi request reprint Alkamides from Echinacea inhibit cyclooxygenase-2 activity in human neuroglioma cells
    Burkhard Hinz
    Institute of Toxicology and Pharmacology, University of Rostock, Schillingallee 70, D 18057 Rostock, Germany
    Biochem Biophys Res Commun 360:441-6. 2007
  7. doi request reprint COX-2 and PPAR-γ confer cannabidiol-induced apoptosis of human lung cancer cells
    Robert Ramer
    Institute of Toxicology and Pharmacology, University of Rostock, Rostock, Germany
    Mol Cancer Ther 12:69-82. 2013
  8. pmc Induction but not inhibition of COX-2 confers human lung cancer cell apoptosis by celecoxib
    Robert Ramer
    Institute of Toxicology and Pharmacology, University of Rostock, Schillingallee 70, D 18057 Rostock, Germany
    J Lipid Res 54:3116-29. 2013
  9. doi request reprint R(+)-methanandamide-induced apoptosis of human cervical carcinoma cells involves a cyclooxygenase-2-dependent pathway
    Karin Eichele
    Institute for Toxicology and Pharmacology, University of Rostock, Schillingallee 70, D 18057, Rostock, Germany
    Pharm Res 26:346-55. 2009
  10. doi request reprint Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1
    Robert Ramer
    Institute of Toxicology and Pharmacology, Department of General Surgery, University of Rostock, Schillingallee 70, D 18057 Rostock, Germany
    FASEB J 26:1535-48. 2012

Collaborators

  • Kay Brune
  • Kirsten Peters
  • Bertold Renner
  • A Pahl
  • Eldad Ben-Chetrit
  • Robert Ramer
  • Jutta Merkord
  • Helga Rohde
  • Ellen Schmuhl
  • Karin Eichele
  • Michael Linnebacher
  • Susanne Rösch
  • Nadine Freimuth
  • Olga Cheremina
  • Andreas Schmidt
  • Ulrike Werner
  • Achim Salamon
  • Philipp Borchert
  • Ulrike Weinzierl
  • Dierk Werner
  • Martin F Fromm
  • Bianca Schwind
  • Stefan Laufer
  • Katharina Heinemann
  • Udo Walther
  • Maria Haustein
  • Katharina Bublitz
  • Anja Rohde
  • Antje Neubert
  • Christoph Lambrecht
  • Iouri Bachmakov
  • Martin Gillich
  • Thomas Rau

Detail Information

Publications39

  1. doi request reprint Paracetamol and cyclooxygenase inhibition: is there a cause for concern?
    Burkhard Hinz
    Institute of Toxicology and Pharmacology, University of Rostock, Schillingallee 70, D 18057 Rostock, Germany
    Ann Rheum Dis 71:20-5. 2012
    ..Finally, paracetamol's fast elimination and consequently short-lived COX-2 inhibition, which requires repetitive dosing, should be definitely considered to avoid overdosage leading to hepatotoxicity...
  2. ncbi request reprint Drug insight: cyclo-oxygenase-2 inhibitors--a critical appraisal
    Burkhard Hinz
    Institute of Toxicology and Pharmacology, University of Rostock, Germany
    Nat Clin Pract Rheumatol 3:552-60; quiz 1 p following 589. 2007
    ..Moreover, this Review summarizes the pharmacology of COX2 inhibitors with emphasis on their different pharmacokinetic characteristics...
  3. ncbi request reprint Impact of naproxen sodium at over-the-counter doses on cyclooxygenase isoforms in human volunteers
    B Hinz
    Institute of Toxicology and Pharmacology, University of Rostock, Schillingallee 70, Rostock, Germany
    Int J Clin Pharmacol Ther 46:180-6. 2008
    ..The present study examines whether naproxen sodium after a single dose administration and at steady state using "over-the-counter (OTC) doses" produces sufficient COX-1 inhibition. COX-2 inhibition was assessed concomitantly...
  4. ncbi request reprint Can drug removals involving cyclooxygenase-2 inhibitors be avoided? A plea for human pharmacology
    Burkhard Hinz
    Institute of Toxicology and Pharmacology, University of Rostock, Schillingallee 70, 18057 Rostock, Germany
    Trends Pharmacol Sci 29:391-7. 2008
    ..In our opinion, such an approach could reduce unwanted drug effects and obviate drug removals...
  5. ncbi request reprint Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man
    Burkhard Hinz
    Institute of Toxicology and Pharmacology, University of Rostock, Schillingallee 70, D 18057 Rostock, Germany
    FASEB J 22:383-90. 2008
    ..In view of its substantial COX-2 inhibition, recently defined cardiovascular warnings for use of COX-2 inhibitors should also be considered for acetaminophen...
  6. ncbi request reprint Alkamides from Echinacea inhibit cyclooxygenase-2 activity in human neuroglioma cells
    Burkhard Hinz
    Institute of Toxicology and Pharmacology, University of Rostock, Schillingallee 70, D 18057 Rostock, Germany
    Biochem Biophys Res Commun 360:441-6. 2007
    ..Overall, our results suggest that certain alkamides derived from E. angustifolia roots may contribute to the pharmacological action of the herbal extract by inhibiting COX-2-dependent PGE2 formation at sites of inflammation...
  7. doi request reprint COX-2 and PPAR-γ confer cannabidiol-induced apoptosis of human lung cancer cells
    Robert Ramer
    Institute of Toxicology and Pharmacology, University of Rostock, Rostock, Germany
    Mol Cancer Ther 12:69-82. 2013
    ..Together, our data show a novel proapoptotic mechanism of cannabidiol involving initial upregulation of COX-2 and PPAR-γ and a subsequent nuclear translocation of PPAR-γ by COX-2-dependent PGs...
  8. pmc Induction but not inhibition of COX-2 confers human lung cancer cell apoptosis by celecoxib
    Robert Ramer
    Institute of Toxicology and Pharmacology, University of Rostock, Schillingallee 70, D 18057 Rostock, Germany
    J Lipid Res 54:3116-29. 2013
    ..Together, our data demonstrate a proapoptotic mechanism of celecoxib involving initial upregulation of COX-2 and PPARγ and a subsequent nuclear translocation of PPARγ by COX-2-dependent PGs...
  9. doi request reprint R(+)-methanandamide-induced apoptosis of human cervical carcinoma cells involves a cyclooxygenase-2-dependent pathway
    Karin Eichele
    Institute for Toxicology and Pharmacology, University of Rostock, Schillingallee 70, D 18057, Rostock, Germany
    Pharm Res 26:346-55. 2009
    ..Using human cervical carcinoma cells (HeLa), this study investigates the role of cyclooxygenase-2 (COX-2) in apoptosis elicited by the endocannabinoid analog R(+)-methanandamide (MA)...
  10. doi request reprint Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1
    Robert Ramer
    Institute of Toxicology and Pharmacology, Department of General Surgery, University of Rostock, Schillingallee 70, D 18057 Rostock, Germany
    FASEB J 26:1535-48. 2012
    ..7% for CBD + isotype antibody and 106.6% for CBD + ICAM-1 antibody]. Overall, our data indicate that cannabinoids induce ICAM-1, thereby conferring TIMP-1 induction and subsequent decreased cancer cell invasiveness...
  11. doi request reprint Decrease of plasminogen activator inhibitor-1 may contribute to the anti-invasive action of cannabidiol on human lung cancer cells
    Robert Ramer
    Institute of Toxicology and Pharmacology, University of Rostock, Schillingallee 70, D 18057, Rostock, Germany
    Pharm Res 27:2162-74. 2010
    ..Using human lung cancer cells, we evaluated the involvement of plasminogen activator inhibitor-1 (PAI-1) in the anti-invasive action of cannabidiol, a non-psychoactive cannabinoid...
  12. ncbi request reprint Increase of mesenchymal stem cell migration by cannabidiol via activation of p42/44 MAPK
    Ellen Schmuhl
    Institute of Toxicology and Pharmacology, University of Rostock, Schillingallee 70, D 18057 Rostock, Germany Department of Cell Biology, University of Rostock, Schillingallee 69, D 18057 Rostock, Germany
    Biochem Pharmacol 87:489-501. 2014
    ..CBD may therefore recruit MSCs to sites of calcifying tissue regeneration and subsequently support bone regeneration via an osteoanabolic action on MSCs. ..
  13. doi request reprint Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1
    Robert Ramer
    Institute of Toxicology and Pharmacology, University of Rostock, Schillingallee 70, D 18057 Rostock, Germany
    Biochem Pharmacol 79:955-66. 2010
    ..Altogether, these findings provide a novel mechanism underlying the anti-invasive action of cannabidiol and imply its use as a therapeutic option for the treatment of highly invasive cancers...
  14. ncbi request reprint Antitumorigenic effects of cannabinoids beyond apoptosis
    Nadine Freimuth
    Institute of Toxicology and Pharmacology, University of Rostock, Rostock, Germany
    J Pharmacol Exp Ther 332:336-44. 2010
    ..The findings discussed here provide a new perspective on the antitumorigenic potential of cannabinoids...
  15. doi request reprint Cyclooxygenase-2 and tissue inhibitor of matrix metalloproteinases-1 confer the antimigratory effect of cannabinoids on human trabecular meshwork cells
    Robert Ramer
    Institute of Toxicology and Pharmacology, University of Rostock, Schillingallee 70, D 18057 Rostock, Germany
    Biochem Pharmacol 80:846-57. 2010
    ..A decreased migration reducing TM cell loss in glaucoma might be involved in the antiglaucomatous action of cannabinoids...
  16. ncbi request reprint Inhibition of cancer cell invasion by cannabinoids via increased expression of tissue inhibitor of matrix metalloproteinases-1
    Robert Ramer
    Institute of Toxicology and Pharmacology, University of Rostock, Schillingallee 70, Rostock D 18057, Germany
    J Natl Cancer Inst 100:59-69. 2008
    ..Although the antiproliferative activities of cannabinoids have been intensively investigated, little is known about their effects on tumor invasion...
  17. ncbi request reprint Cyclooxygenase-2--10 years later
    Burkhard Hinz
    Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    J Pharmacol Exp Ther 300:367-75. 2002
    ..The present review assesses recent advances in COX-2 research, with particular emphasis on new insights into pathophysiological and physiological functions of this isoenzyme...
  18. ncbi request reprint Prostaglandin E2 induces cyclooxygenase-2 expression in human non-pigmented ciliary epithelial cells through activation of p38 and p42/44 mitogen-activated protein kinases
    Susanne Rösch
    Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Fahrstrasse 17, D 91054 Erlangen, Germany
    Biochem Biophys Res Commun 338:1171-8. 2005
    ..Positive feedback regulation of COX-2 may contribute to the production of outflow-facilitating PGs and consequently to regulation of IOP...
  19. ncbi request reprint Up-regulation of cyclooxygenase-2 expression is involved in R(+)-methanandamide-induced apoptotic death of human neuroglioma cells
    Burkhard Hinz
    Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Mol Pharmacol 66:1643-51. 2004
    ....
  20. ncbi request reprint Pain and osteoarthritis: new drugs and mechanisms
    Burkhard Hinz
    Department of Experimental and Clinical Pharmacology and Toxicology, Emil Fischer Center, Friedrich Alexander University Erlangen Nuremberg, Fahrstrasse 17, D 91054 Erlangen, Germany
    Curr Opin Rheumatol 16:628-33. 2004
    ..This review discusses the recent literature on drugs used for symptomatic pain relief in patients with osteoarthritis (OA) as well as potential mechanisms underlying their pharmacologic action...
  21. ncbi request reprint Ceramide is involved in r(+)-methanandamide-induced cyclooxygenase-2 expression in human neuroglioma cells
    Robert Ramer
    Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen, Erlangen, Germany
    Mol Pharmacol 64:1189-98. 2003
    ..Induction of COX-2 expression via ceramide represents a hitherto unknown mechanism by which cannabinoids mediate biological effects within the central nervous system...
  22. ncbi request reprint Aceclofenac spares cyclooxygenase 1 as a result of limited but sustained biotransformation to diclofenac
    Burkhard Hinz
    Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Clin Pharmacol Ther 74:222-35. 2003
    ..This study investigated whether biotransformation to metabolites (4'-hydroxy-aceclofenac, diclofenac, 4'-hydroxy-diclofenac) contributes to inhibitory effects on the cyclooxygenase (COX) isozymes in vitro and ex vivo...
  23. ncbi request reprint R(+)-methanandamide-induced cyclooxygenase-2 expression in H4 human neuroglioma cells: possible involvement of membrane lipid rafts
    Burkhard Hinz
    Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Fahrstrasse 17, D 91054 Erlangen, Germany
    Biochem Biophys Res Commun 324:621-6. 2004
    ..Together, our results suggest that R(+)-MA induces COX-2 expression in human neuroglioma cells via a pathway linked to lipid raft microdomains...
  24. pmc Bioavailability of diclofenac potassium at low doses
    Burkhard Hinz
    Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Fahrstrasse 17, D 91054 Erlangen, Germany
    Br J Clin Pharmacol 59:80-4. 2005
    ..However, given the considerable first-pass metabolism of diclofenac, the degree of absorption of diclofenac-K at low doses remained to be determined. The aim of this study was to determine the bioavailability of low-dose diclofenac-K...
  25. ncbi request reprint The effects of colchicine and hydroxychloroquine on the cyclo-oxygenases COX-1 and COX-2
    Eldad Ben-Chetrit
    FMF Clinic, Department of Medicine, Hadassah University Hospital, POB 12000, Jerusalem, Israel
    Rheumatol Int 25:332-5. 2005
    ..The aim of this study was to test whether colchicine and hydroxychloroquine have an inhibitory effect on cyclo-oxygenases (COX)...
  26. ncbi request reprint Latanoprost induces matrix metalloproteinase-1 expression in human nonpigmented ciliary epithelial cells through a cyclooxygenase-2-dependent mechanism
    Burkhard Hinz
    Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    FASEB J 19:1929-31. 2005
    ..Induction of COX-2- and subsequent MMP-1 expression in the NPE may represent a potential mechanism underlying the IOP-lowering and antiglaucomatous action of latanoprost...
  27. ncbi request reprint Induction of COX-2 expression by the endocannabinoid derivative R(+)-methanandamide
    Burkhard Hinz
    Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nuremberg, Germany
    Adv Exp Med Biol 525:145-52. 2003
  28. ncbi request reprint 15-Deoxy-Delta(12,14)-prostaglandin J2 inhibits the expression of proinflammatory genes in human blood monocytes via a PPAR-gamma-independent mechanism
    Burkhard Hinz
    Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Germany
    Biochem Biophys Res Commun 302:415-20. 2003
    ..Moreover, it is concluded that both inhibition of proinflammatory gene expression and restoration of LPS-induced decrease of PPAR-gamma expression may contribute to the biological action of 15d-PGJ(2)...
  29. ncbi request reprint Simultaneous determination of leflunomide and its active metabolite, A77 1726, in human plasma by high-performance liquid chromatography
    Andreas Schmidt
    Department of Experimental, Friedrich Alexander University Erlangen Nurnberg, Fahrstrasse 17, D 91054 Erlangen, Germany
    Biomed Chromatogr 17:276-81. 2003
    ..1-100 micro g/mL for A77 1726. The developed procedure was applied to assess steady-state plasma concentrations of A77 1726 in patients with rheumatoid arthritis treated with 10 or 20 mg leflunomide per day...
  30. ncbi request reprint Simultaneous determination of aceclofenac and three of its metabolites in human plasma by high-performance liquid chromatography
    Burkhard Hinz
    Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Fahrstrasse 17, D 91054 Erlangen, Germany
    Biomed Chromatogr 17:268-75. 2003
    ..The developed procedure was applied to assess the pharmacokinetics of aceclofenac and its metabolites following administration of a single 100 mg oral dose of aceclofenac to three healthy male volunteers...
  31. ncbi request reprint Celecoxib inhibits metabolism of cytochrome P450 2D6 substrate metoprolol in humans
    Ulrike Werner
    Department of Experimental and Clinical pharmacology and Toxicology and II Medical Clinic, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Clin Pharmacol Ther 74:130-7. 2003
    ..Therefore the objective of this study was to examine the effect of celecoxib and rofecoxib on the pharmacokinetics of the clinically relevant CYP2D6 substrate metoprolol...
  32. ncbi request reprint R(+)-methanandamide elicits a cyclooxygenase-2-dependent mitochondrial apoptosis signaling pathway in human neuroglioma cells
    Karin Eichele
    Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Fahrstrasse 17, D 91054, Erlangen, Germany
    Pharm Res 23:90-4. 2006
    ..The present study investigated a possible involvement of a mitochondrial-driven pathway in this process...
  33. ncbi request reprint A liquid chromatography-mass spectrometry method for the quantification of both etoricoxib and valdecoxib in human plasma
    Ulrike Werner
    Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Biomed Chromatogr 19:113-8. 2005
    ..The presented method was suf fi cient to cover more than 90% of the area under the plasma concentration time curve...
  34. ncbi request reprint Simultaneous determination of oxycodone and its major metabolite, noroxycodone, in human plasma by high-performance liquid chromatography
    Olga Cheremina
    Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Fahrstrasse 17, D 91054 Erlangen, Germany
    Biomed Chromatogr 19:777-82. 2005
    ..The developed procedure was applied to assess the pharmacokinetics of oxycodone and its metabolite following administration of a single 20 mg oral dose of oxycodone hydrochloride to one healthy male volunteer...
  35. ncbi request reprint Dipyrone elicits substantial inhibition of peripheral cyclooxygenases in humans: new insights into the pharmacology of an old analgesic
    Burkhard Hinz
    Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Fahrstrasse 17, D 91054 Erlangen, Germany
    FASEB J 21:2343-51. 2007
    ..In view of the observed COX-1 suppression, physicochemical factors (lack of acidity) rather than differential COX-1 inhibition may be responsible for dipyrone's favorable gastrointestinal tolerability compared with acidic COX inhibitors...
  36. ncbi request reprint A validated high-performance liquid chromatographic assay for determination of lumiracoxib in human plasma
    Olga Cheremina
    Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Fahrstrasse 17, D 91054 Erlangen, Germany
    Biomed Chromatogr 20:1033-7. 2006
    ..The validated quantitation range for lumiracoxib was 10-10,000 ng/mL. The developed procedure was applied to assess the pharmacokinetics of lumiracoxib following administration of a single oral 200 mg dose to a healthy male volunteer...
  37. ncbi request reprint More pronounced inhibition of cyclooxygenase 2, increase in blood pressure, and reduction of heart rate by treatment with diclofenac compared with celecoxib and rofecoxib
    Burkhard Hinz
    Dept of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Fahrstrasse 17, D 91054 Erlangen, Germany
    Arthritis Rheum 54:282-91. 2006
    ....
  38. ncbi request reprint Determination of the endocannabinoid anandamide in human plasma by high-performance liquid chromatography
    Andreas Schmidt
    Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Fahrstrasse 17, D 91054 Erlangen, Germany
    Biomed Chromatogr 20:336-42. 2006
    ..Anandamide levels determined under both conditions were within the validated concentration range with anandamide levels being 2.3-fold higher in plasma from PMSF-treated blood...
  39. ncbi request reprint R(+)-methanandamide and other cannabinoids induce the expression of cyclooxygenase-2 and matrix metalloproteinases in human nonpigmented ciliary epithelial cells
    Susanne Rösch
    Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Fahrstrasse 17, D 91054 Erlangen, Germany
    J Pharmacol Exp Ther 316:1219-28. 2006
    ..In conclusion, stimulation of intraocular COX-2 and MMP expression may represent a potential mechanism contributing to the IOP-lowering action of different cannabinoids...