Research Topics
| Burkhard HinzSummaryAffiliation: University of Rostock Country: Germany Publications
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Detail Information
Publications
Paracetamol and cyclooxygenase inhibition: is there a cause for concern?Burkhard Hinz
Institute of Toxicology and Pharmacology, University of Rostock, Schillingallee 70, D 18057 Rostock, Germany
Ann Rheum Dis 71:20-5. 2012..Finally, paracetamol's fast elimination and consequently short-lived COX-2 inhibition, which requires repetitive dosing, should be definitely considered to avoid overdosage leading to hepatotoxicity...- Can drug removals involving cyclooxygenase-2 inhibitors be avoided? A plea for human pharmacologyBurkhard Hinz
Institute of Toxicology and Pharmacology, University of Rostock, Schillingallee 70, 18057 Rostock, Germany
Trends Pharmacol Sci 29:391-7. 2008..In our opinion, such an approach could reduce unwanted drug effects and obviate drug removals... 
Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in manBurkhard Hinz
Institute of Toxicology and Pharmacology, University of Rostock, Schillingallee 70, D 18057 Rostock, Germany
FASEB J 22:383-90. 2008..In view of its substantial COX-2 inhibition, recently defined cardiovascular warnings for use of COX-2 inhibitors should also be considered for acetaminophen...- Impact of naproxen sodium at over-the-counter doses on cyclooxygenase isoforms in human volunteersB Hinz
Institute of Toxicology and Pharmacology, University of Rostock, Schillingallee 70, Rostock, Germany
Int J Clin Pharmacol Ther 46:180-6. 2008..The present study examines whether naproxen sodium after a single dose administration and at steady state using "over-the-counter (OTC) doses" produces sufficient COX-1 inhibition. COX-2 inhibition was assessed concomitantly... - Alkamides from Echinacea inhibit cyclooxygenase-2 activity in human neuroglioma cellsBurkhard Hinz
Institute of Toxicology and Pharmacology, University of Rostock, Schillingallee 70, D 18057 Rostock, Germany
Biochem Biophys Res Commun 360:441-6. 2007..Overall, our results suggest that certain alkamides derived from E. angustifolia roots may contribute to the pharmacological action of the herbal extract by inhibiting COX-2-dependent PGE2 formation at sites of inflammation... - Drug insight: cyclo-oxygenase-2 inhibitors--a critical appraisalBurkhard Hinz
Institute of Toxicology and Pharmacology, University of Rostock, Germany
Nat Clin Pract Rheumatol 3:552-60; quiz 1 p following 589. 2007..Moreover, this Review summarizes the pharmacology of COX2 inhibitors with emphasis on their different pharmacokinetic characteristics... - R(+)-methanandamide-induced apoptosis of human cervical carcinoma cells involves a cyclooxygenase-2-dependent pathwayKarin Eichele
Institute for Toxicology and Pharmacology, University of Rostock, Schillingallee 70, D 18057, Rostock, Germany
Pharm Res 26:346-55. 2009..Using human cervical carcinoma cells (HeLa), this study investigates the role of cyclooxygenase-2 (COX-2) in apoptosis elicited by the endocannabinoid analog R(+)-methanandamide (MA)... - Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1Robert Ramer
Institute of Toxicology and Pharmacology, Department of General Surgery, University of Rostock, Schillingallee 70, D 18057 Rostock, Germany
FASEB J 26:1535-48. 2012..7% for CBD + isotype antibody and 106.6% for CBD + ICAM-1 antibody]. Overall, our data indicate that cannabinoids induce ICAM-1, thereby conferring TIMP-1 induction and subsequent decreased cancer cell invasiveness... - Decrease of plasminogen activator inhibitor-1 may contribute to the anti-invasive action of cannabidiol on human lung cancer cellsRobert Ramer
Institute of Toxicology and Pharmacology, University of Rostock, Schillingallee 70, D 18057, Rostock, Germany
Pharm Res 27:2162-74. 2010..Using human lung cancer cells, we evaluated the involvement of plasminogen activator inhibitor-1 (PAI-1) in the anti-invasive action of cannabidiol, a non-psychoactive cannabinoid... - Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1Robert Ramer
Institute of Toxicology and Pharmacology, University of Rostock, Schillingallee 70, D 18057 Rostock, Germany
Biochem Pharmacol 79:955-66. 2010..Altogether, these findings provide a novel mechanism underlying the anti-invasive action of cannabidiol and imply its use as a therapeutic option for the treatment of highly invasive cancers... - Antitumorigenic effects of cannabinoids beyond apoptosisNadine Freimuth
Institute of Toxicology and Pharmacology, University of Rostock, Rostock, Germany
J Pharmacol Exp Ther 332:336-44. 2010..The findings discussed here provide a new perspective on the antitumorigenic potential of cannabinoids... - Cyclooxygenase-2 and tissue inhibitor of matrix metalloproteinases-1 confer the antimigratory effect of cannabinoids on human trabecular meshwork cellsRobert Ramer
Institute of Toxicology and Pharmacology, University of Rostock, Schillingallee 70, D 18057 Rostock, Germany
Biochem Pharmacol 80:846-57. 2010..A decreased migration reducing TM cell loss in glaucoma might be involved in the antiglaucomatous action of cannabinoids... - COX-2 and PPAR-γ Confer Cannabidiol-Induced Apoptosis of Human Lung Cancer CellsRobert Ramer
Corresponding Author Burkhard Hinz, Institute of Toxicology and Pharmacology, University of Rostock, Schillingallee 70, D 18057 Rostock, Germany
Mol Cancer Ther 12:69-82. 2013..Mol Cancer Ther; 12(1); 69-82. ©2012 AACR... - Inhibition of cancer cell invasion by cannabinoids via increased expression of tissue inhibitor of matrix metalloproteinases-1Robert Ramer
Institute of Toxicology and Pharmacology, University of Rostock, Schillingallee 70, Rostock D 18057, Germany
J Natl Cancer Inst 100:59-69. 2008..Although the antiproliferative activities of cannabinoids have been intensively investigated, little is known about their effects on tumor invasion... - Cyclooxygenase-2--10 years laterBurkhard Hinz
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
J Pharmacol Exp Ther 300:367-75. 2002..The present review assesses recent advances in COX-2 research, with particular emphasis on new insights into pathophysiological and physiological functions of this isoenzyme... - Prostaglandin E2 induces cyclooxygenase-2 expression in human non-pigmented ciliary epithelial cells through activation of p38 and p42/44 mitogen-activated protein kinasesSusanne Rösch
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Fahrstrasse 17, D 91054 Erlangen, Germany
Biochem Biophys Res Commun 338:1171-8. 2005..Positive feedback regulation of COX-2 may contribute to the production of outflow-facilitating PGs and consequently to regulation of IOP... - Up-regulation of cyclooxygenase-2 expression is involved in R(+)-methanandamide-induced apoptotic death of human neuroglioma cellsBurkhard Hinz
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
Mol Pharmacol 66:1643-51. 2004.... - Pain and osteoarthritis: new drugs and mechanismsBurkhard Hinz
Department of Experimental and Clinical Pharmacology and Toxicology, Emil Fischer Center, Friedrich Alexander University Erlangen Nuremberg, Fahrstrasse 17, D 91054 Erlangen, Germany
Curr Opin Rheumatol 16:628-33. 2004..This review discusses the recent literature on drugs used for symptomatic pain relief in patients with osteoarthritis (OA) as well as potential mechanisms underlying their pharmacologic action... - Ceramide is involved in r(+)-methanandamide-induced cyclooxygenase-2 expression in human neuroglioma cellsRobert Ramer
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen, Erlangen, Germany
Mol Pharmacol 64:1189-98. 2003..Induction of COX-2 expression via ceramide represents a hitherto unknown mechanism by which cannabinoids mediate biological effects within the central nervous system... - Aceclofenac spares cyclooxygenase 1 as a result of limited but sustained biotransformation to diclofenacBurkhard Hinz
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
Clin Pharmacol Ther 74:222-35. 2003..This study investigated whether biotransformation to metabolites (4'-hydroxy-aceclofenac, diclofenac, 4'-hydroxy-diclofenac) contributes to inhibitory effects on the cyclooxygenase (COX) isozymes in vitro and ex vivo... - R(+)-methanandamide-induced cyclooxygenase-2 expression in H4 human neuroglioma cells: possible involvement of membrane lipid raftsBurkhard Hinz
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Fahrstrasse 17, D 91054 Erlangen, Germany
Biochem Biophys Res Commun 324:621-6. 2004..Together, our results suggest that R(+)-MA induces COX-2 expression in human neuroglioma cells via a pathway linked to lipid raft microdomains... 
Bioavailability of diclofenac potassium at low dosesBurkhard Hinz
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Fahrstrasse 17, D 91054 Erlangen, Germany
Br J Clin Pharmacol 59:80-4. 2005..However, given the considerable first-pass metabolism of diclofenac, the degree of absorption of diclofenac-K at low doses remained to be determined. The aim of this study was to determine the bioavailability of low-dose diclofenac-K...- The effects of colchicine and hydroxychloroquine on the cyclo-oxygenases COX-1 and COX-2Eldad Ben-Chetrit
FMF Clinic, Department of Medicine, Hadassah University Hospital, POB 12000, Jerusalem, Israel
Rheumatol Int 25:332-5. 2005..The aim of this study was to test whether colchicine and hydroxychloroquine have an inhibitory effect on cyclo-oxygenases (COX)... - Induction of COX-2 expression by the endocannabinoid derivative R(+)-methanandamideBurkhard Hinz
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen-Nuremberg, Germany
Adv Exp Med Biol 525:145-52. 2003 - 15-Deoxy-Delta(12,14)-prostaglandin J2 inhibits the expression of proinflammatory genes in human blood monocytes via a PPAR-gamma-independent mechanismBurkhard Hinz
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Germany
Biochem Biophys Res Commun 302:415-20. 2003..Moreover, it is concluded that both inhibition of proinflammatory gene expression and restoration of LPS-induced decrease of PPAR-gamma expression may contribute to the biological action of 15d-PGJ(2)... - Latanoprost induces matrix metalloproteinase-1 expression in human nonpigmented ciliary epithelial cells through a cyclooxygenase-2-dependent mechanismBurkhard Hinz
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
FASEB J 19:1929-31. 2005..Induction of COX-2- and subsequent MMP-1 expression in the NPE may represent a potential mechanism underlying the IOP-lowering and antiglaucomatous action of latanoprost... - Simultaneous determination of leflunomide and its active metabolite, A77 1726, in human plasma by high-performance liquid chromatographyAndreas Schmidt
Department of Experimental, , Fahrstrasse 17, D-91054 Erlangen, Germany
Biomed Chromatogr 17:276-81. 2003..1-100 micro g/mL for A77 1726. The developed procedure was applied to assess steady-state plasma concentrations of A77 1726 in patients with rheumatoid arthritis treated with 10 or 20 mg leflunomide per day... - Simultaneous determination of aceclofenac and three of its metabolites in human plasma by high-performance liquid chromatographyBurkhard Hinz
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Fahrstrasse 17, D 91054 Erlangen, Germany
Biomed Chromatogr 17:268-75. 2003..The developed procedure was applied to assess the pharmacokinetics of aceclofenac and its metabolites following administration of a single 100 mg oral dose of aceclofenac to three healthy male volunteers... - Celecoxib inhibits metabolism of cytochrome P450 2D6 substrate metoprolol in humansUlrike Werner
Department of Experimental and Clinical pharmacology and Toxicology and II Medical Clinic, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
Clin Pharmacol Ther 74:130-7. 2003..Therefore the objective of this study was to examine the effect of celecoxib and rofecoxib on the pharmacokinetics of the clinically relevant CYP2D6 substrate metoprolol... - Determination of the endocannabinoid anandamide in human plasma by high-performance liquid chromatographyAndreas Schmidt
Department of Experimental and Clinical Pharmacology and Toxicology, , Fahrstrasse 17, D-91054 Erlangen, Germany
Biomed Chromatogr 20:336-42. 2006..Anandamide levels determined under both conditions were within the validated concentration range with anandamide levels being 2.3-fold higher in plasma from PMSF-treated blood... - A liquid chromatography-mass spectrometry method for the quantification of both etoricoxib and valdecoxib in human plasmaUlrike Werner
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
Biomed Chromatogr 19:113-8. 2005..The presented method was suf fi cient to cover more than 90% of the area under the plasma concentration time curve... - Dipyrone elicits substantial inhibition of peripheral cyclooxygenases in humans: new insights into the pharmacology of an old analgesicBurkhard Hinz
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Fahrstrasse 17, D 91054 Erlangen, Germany
FASEB J 21:2343-51. 2007..In view of the observed COX-1 suppression, physicochemical factors (lack of acidity) rather than differential COX-1 inhibition may be responsible for dipyrone's favorable gastrointestinal tolerability compared with acidic COX inhibitors... - A validated high-performance liquid chromatographic assay for determination of lumiracoxib in human plasmaOlga Cheremina
Department of Experimental and Clinical Pharmacology and Toxicology, , Fahrstrasse 17, D-91054 Erlangen, Germany
Biomed Chromatogr 20:1033-7. 2006..The validated quantitation range for lumiracoxib was 10-10,000 ng/mL. The developed procedure was applied to assess the pharmacokinetics of lumiracoxib following administration of a single oral 200 mg dose to a healthy male volunteer... - More pronounced inhibition of cyclooxygenase 2, increase in blood pressure, and reduction of heart rate by treatment with diclofenac compared with celecoxib and rofecoxibBurkhard Hinz
Dept of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Fahrstrasse 17, D 91054 Erlangen, Germany
Arthritis Rheum 54:282-91. 2006.... - R(+)-methanandamide and other cannabinoids induce the expression of cyclooxygenase-2 and matrix metalloproteinases in human nonpigmented ciliary epithelial cellsSusanne Rösch
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Fahrstrasse 17, D 91054 Erlangen, Germany
J Pharmacol Exp Ther 316:1219-28. 2006..In conclusion, stimulation of intraocular COX-2 and MMP expression may represent a potential mechanism contributing to the IOP-lowering action of different cannabinoids... - Simultaneous determination of oxycodone and its major metabolite, noroxycodone, in human plasma by high-performance liquid chromatographyOlga Cheremina
Department of Experimental and Clinical Pharmacology and Toxicology, , Fahrstrasse 17, D-91054 Erlangen, Germany
Biomed Chromatogr 19:777-82. 2005..The developed procedure was applied to assess the pharmacokinetics of oxycodone and its metabolite following administration of a single 20 mg oral dose of oxycodone hydrochloride to one healthy male volunteer... - R(+)-methanandamide elicits a cyclooxygenase-2-dependent mitochondrial apoptosis signaling pathway in human neuroglioma cellsKarin Eichele
Department of Experimental and Clinical Pharmacology and Toxicology, , Fahrstrasse 17, D-91054, Erlangen, Germany
Pharm Res 23:90-4. 2006..CONCLUSION: R(+)-MA-induced apoptosis is mediated via a mitochondrial-dependent pathway that becomes activated, at least in part, through up-regulation of the COX-2 enzyme...