Research Topics
Genomes and Genes
| Anke HinneySummaryAffiliation: University of Duisburg-Essen Country: Germany Publications
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Detail Information
Publications
Polygenic obesity in humansAnke Hinney
Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
Obes Facts 1:35-42. 2008..In the first GWA for extreme early onset obesity we substantiated that variation in FTO strongly contributes to early onset obesity...- Genome-wide association study in German patients with attention deficit/hyperactivity disorderAnke Hinney
Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
Am J Med Genet B Neuropsychiatr Genet 156:888-97. 2011..The second best SNP is located in an intron of GRM5, a gene located within a recently described region with an infrequent copy number variation in patients with ADHD... 
Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variantsAnke Hinney
Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
PLoS ONE 2:e1361. 2007..Obesity is a major health problem. Although heritability is substantial, genetic mechanisms predisposing to obesity are not very well understood. We have performed a genome wide association study (GWA) for early onset (extreme) obesity...- From monogenic to polygenic obesity: recent advancesAnke Hinney
Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Virchowstrasse 174, Essen, Germany
Eur Child Adolesc Psychiatry 19:297-310. 2010..The development of new strategies for diagnosis, treatment and prevention of obesity can be anticipated... - Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groupsAndre Scherag
Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg Essen, Essen, Germany
PLoS Genet 6:e1000916. 2010..We conclude that the currently known major common variants related to obesity overlap to a substantial degree between children and adults... - Analysis of sequence variations in the suppressor of cytokine signaling (SOCS)-3 gene in extremely obese children and adolescentsKatja Holter
Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps University of Marburg, Germany
BMC Med Genet 8:21. 2007..We investigated association of variations in the coding sequence and promoter region of SOCS3 with extreme obesity in German children and adolescents... - 'Fat mass and obesity associated' gene (FTO): no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescentsTimo D Müller
Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
BMC Med Genet 9:85. 2008..Additionally, we tested for association of rs9939609 alleles with fasting blood parameters indicative of glucose and lipid metabolism... - Mutation screen and association studies in the diacylglycerol O-acyltransferase homolog 2 gene (DGAT2), a positional candidate gene for early onset obesity on chromosome 11q13Susann Friedel
Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
BMC Genet 8:17. 2007..Additionally, we tested for linkage and performed family based association studies at four common variants in the 165 families of our initial genome scan... - Investigation of a genome wide association signal for obesity: synthetic association and haplotype analyses at the melanocortin 4 receptor gene locusAndre Scherag
Institute of Medical Informatics, Biometry and Epidemiology, University of Duisburg Essen, Essen, Germany
PLoS ONE 5:e13967. 2010..As both exist, functionally relevant mutations and polymorphisms in the MC4R coding region and a robust association downstream of the gene, MC4R is an ideal model to explore synthetic association... 
No evidence for an involvement of variants in the cannabinoid receptor gene (CNR1) in obesity in German children and adolescentsTimo Dirk Müller
Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Virchowstr 174, 45147 Essen, Germany
Mol Genet Metab 90:429-34. 2007..In addition, we confirmed the presence of rs1049353. As these variants could not explain the initial TDT, we conclude that there is no evidence for an association of CNR1 alleles with obesity in our study groups...- Gastric inhibitory polypeptide receptor: association analyses for obesity of several polymorphisms in large study groupsCarla I G Vogel
Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
BMC Med Genet 10:19. 2009..We genotyped three GIPR SNPs (rs8111428, rs2302382 and rs1800437) in German families with at least one obese index patient, two case-control studies and two cross-sectional population-based studies... - Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS)Susanne Tan
Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
BMC Med Genet 11:12. 2010..We examined the influence of validated genetic variants conferring susceptibility to obesity and/or type 2 diabetes mellitus (T2DM) on metabolic and PCOS-specific traits in patients with PCOS... - Non-replication of an association of CTNNBL1 polymorphisms and obesity in a population of Central European ancestryCarla I G Vogel
Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
BMC Med Genet 10:14. 2009..We investigated whether variants in CTNNBL1 (including rs6013029) and in three other genes (SH3PXD2B, SLIT3 and FLJ42133,) were associated with obesity... - Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesityTimo D Müller
Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
BMC Med Genet 11:2. 2010..The aim of this study was to analyse whether FAAH alleles are associated with early and late onset obesity... - Prevalence, spectrum, and functional characterization of melanocortin-4 receptor gene mutations in a representative population-based sample and obese adults from GermanyAnke Hinney
Department of Child and Adolescent Psychiatry, Rheinische Kliniken Essen, University of Duisburg Essen, Virchowstrasse 174, 45147 Essen, Germany
J Clin Endocrinol Metab 91:1761-9. 2006..Autosomal dominant inheritance of mutations in the melanocortin-4 receptor gene (MC4R) is currently regarded as the most relevant genetic cause for extreme obesity and affects 2-4% of extremely obese individuals... - Mutation analysis of the MCHR1 gene in human obesityAnne Kathrin Wermter
Clinical Research Group, Department of Child and Adolescent Psychiatry, Rheinische Kliniken Essen, University of Duisburg Essen, 45147 Essen, Germany
Eur J Endocrinol 152:851-62. 2005..The importance of the melanin-concentrating hormone (MCH) system for regulation of energy homeostasis and body weight has been demonstrated in rodents. We analysed the human MCH receptor 1 gene (MCHR1) with respect to human obesity... - Common variants near MC4R: exploring gender effects in overweight and obese children and adolescents participating in a lifestyle interventionCarla I G Vogel
Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
Obes Facts 4:67-75. 2011..Association with obesity and increased insulin levels have been reported for two variants (rs17782313 and rs12970134) located downstream of the melanocortin-4 receptor gene (MC4R)... - Procolipase gene: no association with early-onset obesity or fat intakeAnne Kathrin Wermter
Department of Child and Adolescent Psychiatry, University of Marburg, Germany
Obes Facts 2:40-4. 2009..We explored the relationship between genetic variation in CLPS, early-onset obesity and fat intake in humans... - SDCCAG8 obesity alleles and reduced weight loss after a lifestyle intervention in overweight children and adolescentsAndre Scherag
Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg Essen, Essen, Germany
Obesity (Silver Spring) 20:466-70. 2012..However, our results could not be confirmed in 626 obese adults undertaking a hypoenergetic diet intervention... - Preferential reciprocal transfer of paternal/maternal DLK1 alleles to obese children: first evidence of polar overdominance in humansAnne Kathrin Wermter
Department of Child and Adolescent Psychiatry, University of Marburg, Marburg, Germany
Eur J Hum Genet 16:1126-34. 2008..Analysis of the allelic transmission pattern indicated the existence of polar overdominance, an unusual mode of non-Mendelian inheritance in humans previously known from the callipyge mutation in sheep... - Lack of association of genetic variants in genes of the endocannabinoid system with anorexia nervosaTimo Dirk Müller
Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
Child Adolesc Psychiatry Ment Health 2:33. 2008..The aim of this study was to analyse whether nucleotide sequence variations in the CNR1, FAAH, NAAA and MGLL genes are associated with anorexia nervosa (AN)... - Environmental and genetic risk factors in obesityJohannes Hebebrand
Department of Child and Adolescent Psychiatry, Rheinische Kliniken Essen, University of Duisburg Essen, Virchowstr, 174, D 45147 Essen, Germany
Child Adolesc Psychiatr Clin N Am 18:83-94. 2009..Important factors are socioeconomic status and television consumption. The authors conclude by briefly assessing implications for treatment and prevention of childhood obesity... - Fat mass and obesity-associated gene (FTO) in eating disorders: evidence for association of the rs9939609 obesity risk allele with bulimia nervosa and anorexia nervosaTimo D Müller
Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
Obes Facts 5:408-19. 2012..As genetic variants associated with weight regulation might also be implicated in the etiology of eating disorders, we evaluated whether SNP rs9939609 is associated with bulimia nervosa (BN) and anorexia nervosa (AN)... - Transmission disequilibrium studies in early onset of obsessive-compulsive disorder for polymorphisms in genes of the dopaminergic systemSusanne Walitza
Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
J Neural Transm 115:1071-8. 2008..No evidence of transmission disequilibrium was detected for alleles of the DAT1 and COMT polymorphisms. These polymorphisms do not appear to play a major role in the genetic predisposition to early onset OCD in our study group... - The 103I variant of the melanocortin 4 receptor is associated with low serum triglyceride levelsGünter Brönner
Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Virchowstrasse 174, 45147 Essen, Germany
J Clin Endocrinol Metab 91:535-8. 2006..Recently, the V103I polymorphism of MC4R has been shown to be negatively associated with body mass index. This suggests that serum lipids and blood pressure in individuals carrying the 103I allele might be influenced as well... - Eating disorders: the current status of molecular genetic researchSusann Scherag
Department of Child and Adolescent Psychiatry and Psychotherapy, LVR Klinikum Essen, University of Duisburg Essen, Virchowstrasse 174, Essen, Germany
Eur Child Adolesc Psychiatry 19:211-26. 2010..The elucidation of the molecular mechanisms underlying eating disorders might improve therapeutic approaches... - Child and adolescent psychiatric geneticsJohannes Hebebrand
Department of Child and Adolescent Psychiatry, LVR Klinikum Essen, University of Duisburg Essen, Virchowstrasse 174, Essen, Germany
Eur Child Adolesc Psychiatry 19:259-79. 2010..This review represents the introductory article of this special issue of the European Child and Adolescent Psychiatry... - Chipping away the 'missing heritability': GIANT steps forward in the molecular elucidation of obesity - but still lots to goJohannes Hebebrand
Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
Obes Facts 3:294-303. 2010..The identified variants mostly have small to very small effect sizes; only 1-2% of the BMI variance is explained. Currently, a consensus explanation for this 'missing heritability' in complex diseases has not yet emerged... - Melanocortin-4 receptor gene: case-control study and transmission disequilibrium test confirm that functionally relevant mutations are compatible with a major gene effect for extreme obesityAnke Hinney
Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps University of Marburg, D 35039 Marburg, Germany
J Clin Endocrinol Metab 88:4258-67. 2003..8% (P = 0.033; exact one-sided McNemar test). These results support the hypothesis that these MC4R mutations represent major gene effects for obesity... - Genetic factors for overweight and CADGünter Brönner
Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, and Medical Clinic II, University Hospital Schleswig Holstein, Campus Luebeck, Germany
Herz 31:189-99. 2006..g., animal models, linkage studies, association studies, etc.). These methods are discussed either in the paragraphs on obesity or on CAD; the described principles apply to both phenotypes... - Successful methylphenidate treatment of early onset extreme obesity in a child with a melanocortin-4 receptor gene mutation and attention deficit/hyperactivity disorderOzgür Albayrak
Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Virchowstr 174, D 45147 Essen, Germany
Eur J Pharmacol 660:165-70. 2011..The potential benefit of methylphenidate in obese melanocortin MC(4)receptor mutation carriers with and without co-morbid ADHD warrants further studies... - Human galanin (GAL) and galanin 1 receptor (GALR1) variations are not involved in fat intake and early onset obesityNadine Schäuble
Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps University of Marburg, Germany
J Nutr 135:1387-92. 2005..244G-->A revealed no transmission disequilibrium. We conclude that the analyzed SNPs in GAL and GALR1 do not play a major role in early onset obesity or dietary fat intake in the obese children and adolescents of our study groups... - Lack of association between the -759C/T polymorphism of the 5-HT2C receptor gene and clozapine-induced weight gain among German schizophrenic individualsFrank M Theisen
Clinical Research Group, Department of Child and Adolescent Psychiatry, University of Marburg, Germany
Psychiatr Genet 14:139-42. 2004..Further pharmacogenetic studies pertaining to antipsychotic-induced weight gain are warranted... - Val103Ile polymorphism of the melanocortin-4 receptor gene (MC4R) in cancer cachexiaSusanne Knoll
Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Germany
BMC Cancer 8:85. 2008..We tested if cancer patients that are homo-/heterozygous for the Val103Ile polymorphism are more likely to develop cachexia and/or a loss of appetite than non-carriers of the 103Ile-allele... - Genetic risk factors in eating disordersAnke Hinney
Department of Child and Adolescent Psychiatry, Clinical Research Group, Philipps University of Marburg, Marburg, Germany
Am J Pharmacogenomics 4:209-23. 2004..Fine mapping of one of these regions led to the identification of genes where an association with anorexia nervosa was detected. Currently treatment of patients with eating disorders can not rely on results of molecular genetic studies... - Genetic findings in anorexia and bulimia nervosaAnke Hinney
Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Germany
Prog Mol Biol Transl Sci 94:241-70. 2010..Currently, an international consortium is conducting a genome-wide association study for AN, which will hopefully lead to the identification of the first genome-wide significant markers... - Ghrelin gene: identification of missense variants and a frameshift mutation in extremely obese children and adolescents and healthy normal weight studentsAnke Hinney
Clinical Research Group, Department of Child and Adolescent Psychiatry, University of Marburg, 35033 Marburg, Germany
J Clin Endocrinol Metab 87:2716. 2002..A frameshift mutation was detected in a normal weight individual. None of the variants seem to influence weight regulation... - Meta-analysis on the effect of the N363S polymorphism of the glucocorticoid receptor gene (GRL) on human obesityAmelia Marti
Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
BMC Med Genet 7:50. 2006..Individual studies may lack statistical power which may result in disparate results. This limitation can be overcome using meta-analytic techniques... - Ghrelin receptor gene: identification of several sequence variants in extremely obese children and adolescents, healthy normal-weight and underweight students, and children with short normal statureHai Jun Wang
Institute of Child and Adolescent Health, Health Science Center, Peking University, Beijing 100083, China
J Clin Endocrinol Metab 89:157-62. 2004..In conclusion, we did not obtain conclusive evidence for an involvement of the ghrelin receptor gene in body weight regulation or SNS in our study groups... - Case-control and combined family trios analysis of three polymorphisms in the ghrelin gene in European patients with anorexia and bulimia nervosaElena Cellini
Department of Neurology and Psychiatric Sciences, University of Florence, Florence, Italy
Psychiatr Genet 16:51-2. 2006 - A common genetic variant is associated with adult and childhood obesityAlan Herbert
Department of Genetics and Genomics, Boston University Medical School, E613, 715 Albany Street, Boston, MA 02118, USA
Science 312:279-83. 2006..The obesity-predisposing genotype is present in 10% of individuals. Our study suggests that common genetic polymorphisms are important determinants of obesity... - Common variants near MC4R are associated with fat mass, weight and risk of obesityRuth J F Loos
MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
Nat Genet 40:768-75. 2008.... - Glucose transporter 4 gene: association studies pertaining to alleles of two polymorphisms in extremely obese children and adolescents and in normal and underweight controlsSusann Friedel
Clinical Research Group, Child and Adolescent Psychiatry, Philipps University of Marburg, Germany
Ann N Y Acad Sci 967:554-7. 2002..05). Hence, we did not detect association of any of the analyzed SNP alleles in the GLUT4 to different weight extremes, so these seem not to be involved in weight regulation in our study groups... - Evidence for involvement of the vitamin D receptor gene in idiopathic short stature via a genome-wide linkage study and subsequent association studiesAstrid Dempfle
Institute of Medical Biometry and Epidemiology, Philipps University Marburg, Germany
Hum Mol Genet 15:2772-83. 2006..In conclusion, we identified significant linkage, which might be due to a functional SNP in the vitamin D receptor (VDR) gene and could be responsible for up to 34% of ISS cases in the population... - Hyperphagia, not hypometabolism, causes early onset obesity in melanocortin-4 receptor knockout miceKarin Weide
Max Planck Institut fuer physiologische und klinische Forschung, W G Kerckhoff Institut, D 61231 Bad Nauheim, Germany
Physiol Genomics 13:47-56. 2003.... - Confidence intervals for genotype relative risks and allele frequencies from the case parent trio design for candidate-gene studiesAndre Scherag
Institute of Medical Biometry and Epidemiology, Clinic of Child and Adolescent Psychiatry, University of Marburg, Marburg, Germany
Hum Hered 54:210-7. 2002.... - Melanocortin-4 receptor gene variant I103 is negatively associated with obesityFrank Geller
Institute of Medical Biometry and Epidemiology, Philipps University, Marburg, Germany
Am J Hum Genet 74:572-81. 2004..The respective protective effect against obesity implies that variation in the MC4R gene entails both loss and gain of function... - Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populationsMarta Ribases
Genes and Disease Program, Center for Genomic Regulation, Barcelona Biomedical Research Park, Barcelona, Spain
Hum Mol Genet 13:1205-12. 2004..These are the first two variants associated with the pathophysiology of ED in different populations and support a role for BDNF in the susceptibility to aberrant eating behaviors... - No evidence for involvement of the calpain-10 gene 'high-risk' haplotype combination for non-insulin-dependent diabetes mellitus in early onset obesityAnke Hinney
Department of Child and Adolescent Psychiatry of the Philipps University Marburg, Clinical Research Group, Schützenstr 49, Germany
Mol Genet Metab 76:152-6. 2002..4). All subsequent exploratory analyses were negative. Our analysis of the relationship between the NIDDM 'high-risk' haplotype combination and extreme early onset obesity revealed no evidence for linkage and association... - Genome scan for childhood and adolescent obesity in German familiesKathrin Saar
Molecular Genetics and Gene Mapping Center, , Berlin, Germany
Pediatrics 111:321-7. 2003..The genetic basis of childhood and adolescent obesity might not differ that much from adult obesity... - Brain-derived neurotrophic factor V66M polymorphism in childhood-onset obsessive-compulsive disorderRainald Mossner
Int J Neuropsychopharmacol 8:133-6. 2005 - Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolutionAgnar Helgason
deCODE Genetics, 101 Reykjavik, Iceland
Nat Genet 39:218-25. 2007.... - Definable somatic disorders in overweight children and adolescentsThomas Reinehr
Vestische Hospital for Children and Adolescents, University of Witten Herdecke, Datteln, Germany
J Pediatr 150:618-22, 622.e1-5. 2007..To analyze the frequencies and clinical presentation of definable somatic disorders in children who are overweight... - Is information on genetic determinants of obesity helpful or harmful for obese people?--A randomized clinical trialWinfried Rief
Department of Clinical Psychology and Psychotherapy, University of Marburg, Marburg, Germany
J Gen Intern Med 22:1553-9. 2007..Therefore, we assessed the positive and negative effects of informing obese people about the genetic etiology of being overweight... - Evidence of an influence of a polymorphism near the INSIG2 on weight loss during a lifestyle intervention in obese children and adolescentsThomas Reinehr
Vestische Hospital for Children and Adolescents, University of Witten Herdecke, Dr F Steiner Str 5, 45711 Datteln, Germany
Diabetes 57:623-6. 2008..The aim of this study was to analyze whether children homozygous for the C-allele lose less weight in an intervention than children with the GG- or GC-genotype... - [Genetic findings in Attention-Deficit and Hyperactivity Disorder (ADHD)]Benno Graf Schimmelmann
Klinik fur Psychiatrie und Psychotherapie des Kindes und Jugendalters, Universitat Duisburg Essen, Rheinische Kliniken Essen, Virchowstrasse 174, DE 45147 Essen
Z Kinder Jugendpsychiatr Psychother 34:425-33. 2006..The understanding of ADHD's neurobiology may be advanced by new technologies, such as SNP-based genome scans performed with gene chips comprising 10,000-1,000,000 SNPs, as well as using more sophisticated animal model designs... - Association of NTRK3 and its interaction with NGF suggest an altered cross-regulation of the neurotrophin signaling pathway in eating disordersJosep Maria Mercader
Genes and Disease Program, Center for Genomic Regulation, 08003 Barcelona, Catalonia, Spain
Hum Mol Genet 17:1234-44. 2008..The reported data, in addition to the previous reported findings for BDNF and NTRK2, point neurotrophin signaling genes as key regulators of eating behavior and their altered cross-regulation as susceptibility factors for EDs... - Association of the MC4R V103I polymorphism with the metabolic syndrome: the KORA StudyIris M Heid
Institute of Epidemiology, GSF National Research Center for Environment and Health, Neuherberg, Germany
Obesity (Silver Spring) 16:369-76. 2008..This study aims to provide epidemiological evidence for showing the association of this polymorphism with features of the metabolic syndrome and with parameters related to energy expenditure and dietary habits as potential mediators... - A role for beta-melanocyte-stimulating hormone in human body-weight regulationHeike Biebermann
Institute for Pediatric Endocrinology, Charite Universitatsmedizin Berlin, 13353 Berlin, Germany
Cell Metab 3:141-6. 2006..In vitro and in vivo data as well as postmortem human brain studies indicate that the POMC-derived neuropeptide beta-MSH plays a critical role in the hypothalamic control of body weight in humans... - Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in children and adolescents with obsessive-compulsive disorderRainald Mossner
Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg, Germany
Int J Neuropsychopharmacol 9:437-42. 2006..58 (95% CI 0.98-6.82). In conclusion, the results link TPH2 variations to the pathogenesis of early-onset OCD and further support the aetiological relevance of 5-HT signalling in OCD... - Lack of support for the association between GAD2 polymorphisms and severe human obesityMichael M Swarbrick
Diabetes Center, University of California, San Francisco, California, USA
PLoS Biol 3:e315. 2005.... - Association of BDNF with restricting anorexia nervosa and minimum body mass index: a family-based association study of eight European populationsMarta Ribases
Genes and Disease Program, Center for Genomic Regulation, Barcelona Biomedical Research Park, Barcelona, Spain
Eur J Hum Genet 13:428-34. 2005..These results support the involvement of BDNF in eating behaviour and further suggest its participation in the genetic susceptibility to ED, mainly ANR and low minBMI... - The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohortsHelen N Lyon
Program in Genomics, Divisions of Genetics and Endocrinology, Children s Hospital, Boston, Massachusetts, USA
PLoS Genet 3:e61. 2007....