Anke Hinney

Summary

Affiliation: University of Duisburg-Essen
Country: Germany

Publications

  1. pmc Eating disorders: the current status of molecular genetic research
    Susann Scherag
    Department of Child and Adolescent Psychiatry and Psychotherapy, LVR Klinikum Essen, University of Duisburg Essen, Virchowstrasse 174, Essen, Germany
    Eur Child Adolesc Psychiatry 19:211-26. 2010
  2. pmc Genome-wide analysis of rare copy number variations reveals PARK2 as a candidate gene for attention-deficit/hyperactivity disorder
    I Jarick
    Institute of Medical Biometry and Epidemiology, University of Marburg, Marburg, Germany
    Mol Psychiatry 19:115-21. 2014
  3. ncbi request reprint Genetics of eating disorders
    Anke Hinney
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Virchowstrasse 171, 45147, Essen, Germany
    Curr Psychiatry Rep 15:423. 2013
  4. doi request reprint Genome-wide association study in German patients with attention deficit/hyperactivity disorder
    Anke Hinney
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    Am J Med Genet B Neuropsychiatr Genet 156:888-97. 2011
  5. pmc Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants
    Anke Hinney
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    PLoS ONE 2:e1361. 2007
  6. pmc From monogenic to polygenic obesity: recent advances
    Anke Hinney
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Virchowstrasse 174, Essen, Germany
    Eur Child Adolesc Psychiatry 19:297-310. 2010
  7. doi request reprint Polygenic obesity in humans
    Anke Hinney
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
    Obes Facts 1:35-42. 2008
  8. pmc Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups
    Andre Scherag
    Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg Essen, Essen, Germany
    PLoS Genet 6:e1000916. 2010
  9. doi request reprint A consultation with genetic information about obesity decreases self-blame about eating and leads to realistic weight loss goals in obese individuals
    Matthias Conradt
    Psychology Department, Marburg University, Marburg, Germany
    J Psychosom Res 66:287-95. 2009
  10. pmc Mutation screen and association studies in the diacylglycerol O-acyltransferase homolog 2 gene (DGAT2), a positional candidate gene for early onset obesity on chromosome 11q13
    Susann Friedel
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    BMC Genet 8:17. 2007

Detail Information

Publications77

  1. pmc Eating disorders: the current status of molecular genetic research
    Susann Scherag
    Department of Child and Adolescent Psychiatry and Psychotherapy, LVR Klinikum Essen, University of Duisburg Essen, Virchowstrasse 174, Essen, Germany
    Eur Child Adolesc Psychiatry 19:211-26. 2010
    ..The elucidation of the molecular mechanisms underlying eating disorders might improve therapeutic approaches...
  2. pmc Genome-wide analysis of rare copy number variations reveals PARK2 as a candidate gene for attention-deficit/hyperactivity disorder
    I Jarick
    Institute of Medical Biometry and Epidemiology, University of Marburg, Marburg, Germany
    Mol Psychiatry 19:115-21. 2014
    ..3 × 10(-2)). Our results suggest that copy number variants at the PARK2 locus contribute to the genetic susceptibility of ADHD. Mutations and CNVs in PARK2 are known to be associated with Parkinson disease...
  3. ncbi request reprint Genetics of eating disorders
    Anke Hinney
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Virchowstrasse 171, 45147, Essen, Germany
    Curr Psychiatry Rep 15:423. 2013
    ..Genome-wide association studies have hinted to formerly unknown genetic regions. However, significant genome-wide findings have not yet been reported. ..
  4. doi request reprint Genome-wide association study in German patients with attention deficit/hyperactivity disorder
    Anke Hinney
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    Am J Med Genet B Neuropsychiatr Genet 156:888-97. 2011
    ..The second best SNP is located in an intron of GRM5, a gene located within a recently described region with an infrequent copy number variation in patients with ADHD...
  5. pmc Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants
    Anke Hinney
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    PLoS ONE 2:e1361. 2007
    ..Obesity is a major health problem. Although heritability is substantial, genetic mechanisms predisposing to obesity are not very well understood. We have performed a genome wide association study (GWA) for early onset (extreme) obesity...
  6. pmc From monogenic to polygenic obesity: recent advances
    Anke Hinney
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Virchowstrasse 174, Essen, Germany
    Eur Child Adolesc Psychiatry 19:297-310. 2010
    ..The development of new strategies for diagnosis, treatment and prevention of obesity can be anticipated...
  7. doi request reprint Polygenic obesity in humans
    Anke Hinney
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
    Obes Facts 1:35-42. 2008
    ..In the first GWA for extreme early onset obesity we substantiated that variation in FTO strongly contributes to early onset obesity...
  8. pmc Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups
    Andre Scherag
    Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg Essen, Essen, Germany
    PLoS Genet 6:e1000916. 2010
    ..We conclude that the currently known major common variants related to obesity overlap to a substantial degree between children and adults...
  9. doi request reprint A consultation with genetic information about obesity decreases self-blame about eating and leads to realistic weight loss goals in obese individuals
    Matthias Conradt
    Psychology Department, Marburg University, Marburg, Germany
    J Psychosom Res 66:287-95. 2009
    ..Furthermore, the study sought to explore possible predictors for weight gain/loss...
  10. pmc Mutation screen and association studies in the diacylglycerol O-acyltransferase homolog 2 gene (DGAT2), a positional candidate gene for early onset obesity on chromosome 11q13
    Susann Friedel
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    BMC Genet 8:17. 2007
    ..Additionally, we tested for linkage and performed family based association studies at four common variants in the 165 families of our initial genome scan...
  11. pmc 'Fat mass and obesity associated' gene (FTO): no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents
    Timo D Müller
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
    BMC Med Genet 9:85. 2008
    ..Additionally, we tested for association of rs9939609 alleles with fasting blood parameters indicative of glucose and lipid metabolism...
  12. pmc Analysis of sequence variations in the suppressor of cytokine signaling (SOCS)-3 gene in extremely obese children and adolescents
    Katja Holter
    Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps University of Marburg, Germany
    BMC Med Genet 8:21. 2007
    ..We investigated association of variations in the coding sequence and promoter region of SOCS3 with extreme obesity in German children and adolescents...
  13. pmc Investigation of a genome wide association signal for obesity: synthetic association and haplotype analyses at the melanocortin 4 receptor gene locus
    Andre Scherag
    Institute of Medical Informatics, Biometry and Epidemiology, University of Duisburg Essen, Essen, Germany
    PLoS ONE 5:e13967. 2010
    ..As both exist, functionally relevant mutations and polymorphisms in the MC4R coding region and a robust association downstream of the gene, MC4R is an ideal model to explore synthetic association...
  14. ncbi request reprint Mutation analysis of the MCHR1 gene in human obesity
    Anne Kathrin Wermter
    Clinical Research Group, Department of Child and Adolescent Psychiatry, Rheinische Kliniken Essen, University of Duisburg Essen, 45147 Essen, Germany
    Eur J Endocrinol 152:851-62. 2005
    ..The importance of the melanin-concentrating hormone (MCH) system for regulation of energy homeostasis and body weight has been demonstrated in rodents. We analysed the human MCH receptor 1 gene (MCHR1) with respect to human obesity...
  15. ncbi request reprint No evidence for an involvement of variants in the cannabinoid receptor gene (CNR1) in obesity in German children and adolescents
    Timo Dirk Müller
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Virchowstr 174, 45147 Essen, Germany
    Mol Genet Metab 90:429-34. 2007
    ..In addition, we confirmed the presence of rs1049353. As these variants could not explain the initial TDT, we conclude that there is no evidence for an association of CNR1 alleles with obesity in our study groups...
  16. ncbi request reprint Prevalence, spectrum, and functional characterization of melanocortin-4 receptor gene mutations in a representative population-based sample and obese adults from Germany
    Anke Hinney
    Department of Child and Adolescent Psychiatry, Rheinische Kliniken Essen, University of Duisburg Essen, Virchowstrasse 174, 45147 Essen, Germany
    J Clin Endocrinol Metab 91:1761-9. 2006
    ..Autosomal dominant inheritance of mutations in the melanocortin-4 receptor gene (MC4R) is currently regarded as the most relevant genetic cause for extreme obesity and affects 2-4% of extremely obese individuals...
  17. pmc Gastric inhibitory polypeptide receptor: association analyses for obesity of several polymorphisms in large study groups
    Carla I G Vogel
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    BMC Med Genet 10:19. 2009
    ..We genotyped three GIPR SNPs (rs8111428, rs2302382 and rs1800437) in German families with at least one obese index patient, two case-control studies and two cross-sectional population-based studies...
  18. pmc Mutation screen in the GWAS derived obesity gene SH2B1 including functional analyses of detected variants
    Anna Lena Volckmar
    Department of Child and Adolescent Psychiatry, University Duisburg Essen, Virchowstr, 171, D 45147, Essen, Germany
    BMC Med Genomics 5:65. 2012
    ..Large scale GWAS studies depicted markers in the vicinity of the gene; animal models suggest a potential relevance for human body weight regulation...
  19. pmc Novel common copy number variation for early onset extreme obesity on chromosome 11q11 identified by a genome-wide analysis
    Ivonne Jarick
    Institute of Medical Biometry and Epidemiology, Philipps University of Marburg, Bunsenstraße 3, D 35037 Marburg, Germany
    Hum Mol Genet 20:840-52. 2011
    ..However, rare CNVs had not been the focus of our study. We conclude that common CNVs are unlikely to contribute substantially to the genetic basis of early-onset extreme obesity...
  20. doi request reprint Procolipase gene: no association with early-onset obesity or fat intake
    Anne Kathrin Wermter
    Department of Child and Adolescent Psychiatry, University of Marburg, Germany
    Obes Facts 2:40-4. 2009
    ..We explored the relationship between genetic variation in CLPS, early-onset obesity and fat intake in humans...
  21. ncbi request reprint Preferential reciprocal transfer of paternal/maternal DLK1 alleles to obese children: first evidence of polar overdominance in humans
    Anne Kathrin Wermter
    Department of Child and Adolescent Psychiatry, University of Marburg, Marburg, Germany
    Eur J Hum Genet 16:1126-34. 2008
    ..Analysis of the allelic transmission pattern indicated the existence of polar overdominance, an unusual mode of non-Mendelian inheritance in humans previously known from the callipyge mutation in sheep...
  22. pmc Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity
    Timo D Müller
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
    BMC Med Genet 11:2. 2010
    ..The aim of this study was to analyse whether FAAH alleles are associated with early and late onset obesity...
  23. pmc Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS)
    Susanne Tan
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    BMC Med Genet 11:12. 2010
    ..We examined the influence of validated genetic variants conferring susceptibility to obesity and/or type 2 diabetes mellitus (T2DM) on metabolic and PCOS-specific traits in patients with PCOS...
  24. pmc Non-replication of an association of CTNNBL1 polymorphisms and obesity in a population of Central European ancestry
    Carla I G Vogel
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    BMC Med Genet 10:14. 2009
    ..We investigated whether variants in CTNNBL1 (including rs6013029) and in three other genes (SH3PXD2B, SLIT3 and FLJ42133,) were associated with obesity...
  25. doi request reprint Common variants near MC4R: exploring gender effects in overweight and obese children and adolescents participating in a lifestyle intervention
    Carla I G Vogel
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    Obes Facts 4:67-75. 2011
    ..Association with obesity and increased insulin levels have been reported for two variants (rs17782313 and rs12970134) located downstream of the melanocortin-4 receptor gene (MC4R)...
  26. pmc Molecular genetic aspects of weight regulation
    Johannes Hebebrand
    Department of Child and Adolescent Psychiatry, LVR Klinikum Essen, University of Duisburg Essen, Wickenburgstrasse 21, Essen, Germany
    Dtsch Arztebl Int 110:338-44. 2013
    ..Family and twin studies have empirically revealed a 40% to 70% heritability of body-mass index, yet only a few hereditary factors have been identified to date that increase the risk of being overweight...
  27. doi request reprint Fat mass and obesity-associated gene (FTO) in eating disorders: evidence for association of the rs9939609 obesity risk allele with bulimia nervosa and anorexia nervosa
    Timo D Müller
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
    Obes Facts 5:408-19. 2012
    ..As genetic variants associated with weight regulation might also be implicated in the etiology of eating disorders, we evaluated whether SNP rs9939609 is associated with bulimia nervosa (BN) and anorexia nervosa (AN)...
  28. doi request reprint Environmental and genetic risk factors in obesity
    Johannes Hebebrand
    Department of Child and Adolescent Psychiatry, Rheinische Kliniken Essen, University of Duisburg Essen, Virchowstr, 174, D 45147 Essen, Germany
    Child Adolesc Psychiatr Clin N Am 18:83-94. 2009
    ..Important factors are socioeconomic status and television consumption. The authors conclude by briefly assessing implications for treatment and prevention of childhood obesity...
  29. doi request reprint Evaluation of the obesity genes FTO and MC4R and the type 2 diabetes mellitus gene TCF7L2 for contribution to stroke risk: The Mannheim-Heidelberg Stroke Study
    Yaroslav Winter
    Department of Neurology, Philipps University Marburg, Marburg, Germany
    Obes Facts 4:290-6. 2011
    ..The objective was to investigate the genetic markers related to obesity genes FTO and MC4R and the gene of type 2 diabetes mellitus TCF7L2 for their contribution to risk of stroke and transient ischemic attacks (TIA)...
  30. pmc Mitochondrial DNA variants in obesity
    Nadja Knoll
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    PLoS ONE 9:e94882. 2014
    ....
  31. doi request reprint Successful treatment with atomoxetine of an adolescent boy with attention deficit/hyperactivity disorder, extreme obesity, and reduced melanocortin 4 receptor function
    Wilfried Pott
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Faculty of Human Medicine, Philipps University Marburg, Germany
    Obes Facts 6:109-15. 2013
    ..Recent case reports suggest a link between reduced melanocortinergic tone and both obesity and attention deficit / hyperactivity disorder (ADHD). We present the case of a 13-year-old, male, obese MC4R mutation carrier with ADHD...
  32. doi request reprint SDCCAG8 obesity alleles and reduced weight loss after a lifestyle intervention in overweight children and adolescents
    Andre Scherag
    Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg Essen, Essen, Germany
    Obesity (Silver Spring) 20:466-70. 2012
    ..However, our results could not be confirmed in 626 obese adults undertaking a hypoenergetic diet intervention...
  33. pmc Lack of association of genetic variants in genes of the endocannabinoid system with anorexia nervosa
    Timo Dirk Müller
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    Child Adolesc Psychiatry Ment Health 2:33. 2008
    ..The aim of this study was to analyse whether nucleotide sequence variations in the CNR1, FAAH, NAAA and MGLL genes are associated with anorexia nervosa (AN)...
  34. pmc Gene set of nuclear-encoded mitochondrial regulators is enriched for common inherited variation in obesity
    Nadja Knoll
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    PLoS ONE 8:e55884. 2013
    ..1052, p(MAGENTA,75) = 0.0251). The GSEA revealed that weak association signals for obesity might be enriched in the gene set of 16 nuclear regulators of mitochondrial genes...
  35. doi request reprint Chipping away the 'missing heritability': GIANT steps forward in the molecular elucidation of obesity - but still lots to go
    Johannes Hebebrand
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
    Obes Facts 3:294-303. 2010
    ..The identified variants mostly have small to very small effect sizes; only 1-2% of the BMI variance is explained. Currently, a consensus explanation for this 'missing heritability' in complex diseases has not yet emerged...
  36. ncbi request reprint Evidence for involvement of the vitamin D receptor gene in idiopathic short stature via a genome-wide linkage study and subsequent association studies
    Astrid Dempfle
    Institute of Medical Biometry and Epidemiology, Philipps University Marburg, Germany
    Hum Mol Genet 15:2772-83. 2006
    ..In conclusion, we identified significant linkage, which might be due to a functional SNP in the vitamin D receptor (VDR) gene and could be responsible for up to 34% of ISS cases in the population...
  37. doi request reprint Transmission disequilibrium studies in early onset of obsessive-compulsive disorder for polymorphisms in genes of the dopaminergic system
    Susanne Walitza
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    J Neural Transm 115:1071-8. 2008
    ..No evidence of transmission disequilibrium was detected for alleles of the DAT1 and COMT polymorphisms. These polymorphisms do not appear to play a major role in the genetic predisposition to early onset OCD in our study group...
  38. ncbi request reprint The 103I variant of the melanocortin 4 receptor is associated with low serum triglyceride levels
    Günter Brönner
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Virchowstrasse 174, 45147 Essen, Germany
    J Clin Endocrinol Metab 91:535-8. 2006
    ..Recently, the V103I polymorphism of MC4R has been shown to be negatively associated with body mass index. This suggests that serum lipids and blood pressure in individuals carrying the 103I allele might be influenced as well...
  39. ncbi request reprint Melanocortin-4 receptor gene: case-control study and transmission disequilibrium test confirm that functionally relevant mutations are compatible with a major gene effect for extreme obesity
    Anke Hinney
    Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps University of Marburg, D 35039 Marburg, Germany
    J Clin Endocrinol Metab 88:4258-67. 2003
    ..8% (P = 0.033; exact one-sided McNemar test). These results support the hypothesis that these MC4R mutations represent major gene effects for obesity...
  40. ncbi request reprint Human galanin (GAL) and galanin 1 receptor (GALR1) variations are not involved in fat intake and early onset obesity
    Nadine Schäuble
    Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps University of Marburg, Germany
    J Nutr 135:1387-92. 2005
    ..244G-->A revealed no transmission disequilibrium. We conclude that the analyzed SNPs in GAL and GALR1 do not play a major role in early onset obesity or dietary fat intake in the obese children and adolescents of our study groups...
  41. pmc Melanocortin-4 receptor gene variant I103 is negatively associated with obesity
    Frank Geller
    Institute of Medical Biometry and Epidemiology, Philipps University, Marburg, Germany
    Am J Hum Genet 74:572-81. 2004
    ..The respective protective effect against obesity implies that variation in the MC4R gene entails both loss and gain of function...
  42. doi request reprint Child and adolescent psychiatric genetics
    Johannes Hebebrand
    Department of Child and Adolescent Psychiatry, LVR Klinikum Essen, University of Duisburg Essen, Virchowstrasse 174, Essen, Germany
    Eur Child Adolesc Psychiatry 19:259-79. 2010
    ..This review represents the introductory article of this special issue of the European Child and Adolescent Psychiatry...
  43. doi request reprint Common obesity risk alleles in childhood attention-deficit/hyperactivity disorder
    Ozgür Albayrak
    Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, LVR Klinikum Essen, University of Duisburg Essen, D 45147 Essen, Germany
    Am J Med Genet B Neuropsychiatr Genet 162:295-305. 2013
    ..Our results justify further research on the elucidation of the common genetic background of ADHD and obesity...
  44. doi request reprint Causal attributions of obese men and women in genetic testing: implications of genetic/biological attributions
    Anja Hilbert
    Department of Psychology, Division of Clinical Psychology and Psychological Therapy, Philipps University of Marburg, Marburg, Germany
    Psychol Health 24:749-61. 2009
    ..Those who attribute their obesity to genetic/biological factors likely have a familial obesity risk...
  45. pmc Is information on genetic determinants of obesity helpful or harmful for obese people?--A randomized clinical trial
    Winfried Rief
    Department of Clinical Psychology and Psychotherapy, University of Marburg, Marburg, Germany
    J Gen Intern Med 22:1553-9. 2007
    ..Therefore, we assessed the positive and negative effects of informing obese people about the genetic etiology of being overweight...
  46. ncbi request reprint Genetic factors for overweight and CAD
    Günter Brönner
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, and Medical Clinic II, University Hospital Schleswig Holstein, Campus Luebeck, Germany
    Herz 31:189-99. 2006
    ..g., animal models, linkage studies, association studies, etc.). These methods are discussed either in the paragraphs on obesity or on CAD; the described principles apply to both phenotypes...
  47. doi request reprint Successful methylphenidate treatment of early onset extreme obesity in a child with a melanocortin-4 receptor gene mutation and attention deficit/hyperactivity disorder
    Ozgür Albayrak
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Virchowstr 174, D 45147 Essen, Germany
    Eur J Pharmacol 660:165-70. 2011
    ..The potential benefit of methylphenidate in obese melanocortin MC(4)receptor mutation carriers with and without co-morbid ADHD warrants further studies...
  48. pmc Val103Ile polymorphism of the melanocortin-4 receptor gene (MC4R) in cancer cachexia
    Susanne Knoll
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Germany
    BMC Cancer 8:85. 2008
    ..We tested if cancer patients that are homo-/heterozygous for the Val103Ile polymorphism are more likely to develop cachexia and/or a loss of appetite than non-carriers of the 103Ile-allele...
  49. ncbi request reprint Lack of association between the -759C/T polymorphism of the 5-HT2C receptor gene and clozapine-induced weight gain among German schizophrenic individuals
    Frank M Theisen
    Clinical Research Group, Department of Child and Adolescent Psychiatry, University of Marburg, Germany
    Psychiatr Genet 14:139-42. 2004
    ..Further pharmacogenetic studies pertaining to antipsychotic-induced weight gain are warranted...
  50. ncbi request reprint Melanocortin-4 receptor in energy homeostasis and obesity pathogenesis
    Anke Hinney
    Department of Child and Adolescent Psychiatry, Universitatsklinikum, University of Duisburg Essen, Essen, Germany
    Prog Mol Biol Transl Sci 114:147-91. 2013
    ..The functional implication of the finding is still unresolved; an effect on gene expression is the most likely mechanism. Synthetic association could not be detected for the MC4R region...
  51. ncbi request reprint Confidence intervals for genotype relative risks and allele frequencies from the case parent trio design for candidate-gene studies
    Andre Scherag
    Institute of Medical Biometry and Epidemiology, Clinic of Child and Adolescent Psychiatry, University of Marburg, Marburg, Germany
    Hum Hered 54:210-7. 2002
    ....
  52. ncbi request reprint Genetic variation at the CELF1 (CUGBP, elav-like family member 1 gene) locus is genome-wide associated with Alzheimer's disease and obesity
    Anke Hinney
    Department of Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, Universitatsklinikum Essen, University of Duisburg Essen, Essen, Germany
    Am J Med Genet B Neuropsychiatr Genet 165:283-93. 2014
    ..21 × 10(-06) ; pcorr  = 3.24 × 10(-04)). Our first GWAS based cross-disorder analysis for AD and obesity suggests that rs10838725 at the locus CELF1 might be relevant for both disorders...
  53. doi request reprint Genetic findings in anorexia and bulimia nervosa
    Anke Hinney
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Germany
    Prog Mol Biol Transl Sci 94:241-70. 2010
    ..Currently, an international consortium is conducting a genome-wide association study for AN, which will hopefully lead to the identification of the first genome-wide significant markers...
  54. ncbi request reprint Genetic risk factors in eating disorders
    Anke Hinney
    Department of Child and Adolescent Psychiatry, Clinical Research Group, Philipps University of Marburg, Marburg, Germany
    Am J Pharmacogenomics 4:209-23. 2004
    ..Fine mapping of one of these regions led to the identification of genes where an association with anorexia nervosa was detected. Currently treatment of patients with eating disorders can not rely on results of molecular genetic studies...
  55. ncbi request reprint Ghrelin gene: identification of missense variants and a frameshift mutation in extremely obese children and adolescents and healthy normal weight students
    Anke Hinney
    Clinical Research Group, Department of Child and Adolescent Psychiatry, University of Marburg, 35033 Marburg, Germany
    J Clin Endocrinol Metab 87:2716. 2002
    ..A frameshift mutation was detected in a normal weight individual. None of the variants seem to influence weight regulation...
  56. ncbi request reprint Hyperphagia, not hypometabolism, causes early onset obesity in melanocortin-4 receptor knockout mice
    Karin Weide
    Max Planck Institut fuer physiologische und klinische Forschung, W G Kerckhoff Institut, D 61231 Bad Nauheim, Germany
    Physiol Genomics 13:47-56. 2003
    ....
  57. ncbi request reprint Ghrelin receptor gene: identification of several sequence variants in extremely obese children and adolescents, healthy normal-weight and underweight students, and children with short normal stature
    Hai Jun Wang
    Institute of Child and Adolescent Health, Health Science Center, Peking University, Beijing 100083, China
    J Clin Endocrinol Metab 89:157-62. 2004
    ..In conclusion, we did not obtain conclusive evidence for an involvement of the ghrelin receptor gene in body weight regulation or SNS in our study groups...
  58. ncbi request reprint Glucose transporter 4 gene: association studies pertaining to alleles of two polymorphisms in extremely obese children and adolescents and in normal and underweight controls
    Susann Friedel
    Clinical Research Group, Child and Adolescent Psychiatry, Philipps University of Marburg, Germany
    Ann N Y Acad Sci 967:554-7. 2002
    ..05). Hence, we did not detect association of any of the analyzed SNP alleles in the GLUT4 to different weight extremes, so these seem not to be involved in weight regulation in our study groups...
  59. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....
  60. ncbi request reprint Case-control and combined family trios analysis of three polymorphisms in the ghrelin gene in European patients with anorexia and bulimia nervosa
    Elena Cellini
    Department of Neurology and Psychiatric Sciences, University of Florence, Florence, Italy
    Psychiatr Genet 16:51-2. 2006
  61. ncbi request reprint A common genetic variant is associated with adult and childhood obesity
    Alan Herbert
    Department of Genetics and Genomics, Boston University Medical School, E613, 715 Albany Street, Boston, MA 02118, USA
    Science 312:279-83. 2006
    ..The obesity-predisposing genotype is present in 10% of individuals. Our study suggests that common genetic polymorphisms are important determinants of obesity...
  62. pmc Meta-analysis on the effect of the N363S polymorphism of the glucocorticoid receptor gene (GRL) on human obesity
    Amelia Marti
    Department of Physiology and Nutrition, University of Navarra, Pamplona, Spain
    BMC Med Genet 7:50. 2006
    ..Individual studies may lack statistical power which may result in disparate results. This limitation can be overcome using meta-analytic techniques...
  63. doi request reprint Association of the MC4R V103I polymorphism with the metabolic syndrome: the KORA Study
    Iris M Heid
    Institute of Epidemiology, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Obesity (Silver Spring) 16:369-76. 2008
    ..This study aims to provide epidemiological evidence for showing the association of this polymorphism with features of the metabolic syndrome and with parameters related to energy expenditure and dietary habits as potential mediators...
  64. ncbi request reprint No evidence for involvement of the calpain-10 gene 'high-risk' haplotype combination for non-insulin-dependent diabetes mellitus in early onset obesity
    Anke Hinney
    Department of Child and Adolescent Psychiatry of the Philipps University Marburg, Clinical Research Group, Schützenstr 49, Germany
    Mol Genet Metab 76:152-6. 2002
    ..4). All subsequent exploratory analyses were negative. Our analysis of the relationship between the NIDDM 'high-risk' haplotype combination and extreme early onset obesity revealed no evidence for linkage and association...
  65. ncbi request reprint Genome scan for childhood and adolescent obesity in German families
    Kathrin Saar
    Molecular Genetics and Gene Mapping Center, Max Delbruck Center, Berlin, Germany
    Pediatrics 111:321-7. 2003
    ....
  66. doi request reprint Association of NTRK3 and its interaction with NGF suggest an altered cross-regulation of the neurotrophin signaling pathway in eating disorders
    Josep Maria Mercader
    Genes and Disease Program, Center for Genomic Regulation, 08003 Barcelona, Catalonia, Spain
    Hum Mol Genet 17:1234-44. 2008
    ..The reported data, in addition to the previous reported findings for BDNF and NTRK2, point neurotrophin signaling genes as key regulators of eating behavior and their altered cross-regulation as susceptibility factors for EDs...
  67. ncbi request reprint Evidence of an influence of a polymorphism near the INSIG2 on weight loss during a lifestyle intervention in obese children and adolescents
    Thomas Reinehr
    Vestische Hospital for Children and Adolescents, University of Witten Herdecke, Dr F Steiner Str 5, 45711 Datteln, Germany
    Diabetes 57:623-6. 2008
    ..The aim of this study was to analyze whether children homozygous for the C-allele lose less weight in an intervention than children with the GG- or GC-genotype...
  68. ncbi request reprint Definable somatic disorders in overweight children and adolescents
    Thomas Reinehr
    Vestische Hospital for Children and Adolescents, University of Witten Herdecke, Datteln, Germany
    J Pediatr 150:618-22, 622.e1-5. 2007
    ..To analyze the frequencies and clinical presentation of definable somatic disorders in children who are overweight...
  69. ncbi request reprint Brain-derived neurotrophic factor V66M polymorphism in childhood-onset obsessive-compulsive disorder
    Rainald Mossner
    Int J Neuropsychopharmacol 8:133-6. 2005
  70. ncbi request reprint Association of BDNF with restricting anorexia nervosa and minimum body mass index: a family-based association study of eight European populations
    Marta Ribases
    Genes and Disease Program, Center for Genomic Regulation, Barcelona Biomedical Research Park, Barcelona, Spain
    Eur J Hum Genet 13:428-34. 2005
    ..These results support the involvement of BDNF in eating behaviour and further suggest its participation in the genetic susceptibility to ED, mainly ANR and low minBMI...
  71. pmc The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts
    Helen N Lyon
    Program in Genomics, Divisions of Genetics and Endocrinology, Children s Hospital, Boston, Massachusetts, USA
    PLoS Genet 3:e61. 2007
    ....
  72. pmc Lack of support for the association between GAD2 polymorphisms and severe human obesity
    Michael M Swarbrick
    Diabetes Center, University of California, San Francisco, California, USA
    PLoS Biol 3:e315. 2005
    ....
  73. ncbi request reprint Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in children and adolescents with obsessive-compulsive disorder
    Rainald Mossner
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg, Germany
    Int J Neuropsychopharmacol 9:437-42. 2006
    ..58 (95% CI 0.98-6.82). In conclusion, the results link TPH2 variations to the pathogenesis of early-onset OCD and further support the aetiological relevance of 5-HT signalling in OCD...
  74. ncbi request reprint Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution
    Agnar Helgason
    deCODE Genetics, 101 Reykjavik, Iceland
    Nat Genet 39:218-25. 2007
    ....
  75. ncbi request reprint A role for beta-melanocyte-stimulating hormone in human body-weight regulation
    Heike Biebermann
    Institute for Pediatric Endocrinology, Charite Universitatsmedizin Berlin, 13353 Berlin, Germany
    Cell Metab 3:141-6. 2006
    ..In vitro and in vivo data as well as postmortem human brain studies indicate that the POMC-derived neuropeptide beta-MSH plays a critical role in the hypothalamic control of body weight in humans...
  76. ncbi request reprint [Genetic findings in Attention-Deficit and Hyperactivity Disorder (ADHD)]
    Benno Graf Schimmelmann
    Klinik fur Psychiatrie und Psychotherapie des Kindes und Jugendalters, Universitat Duisburg Essen, Rheinische Kliniken Essen, Virchowstrasse 174, DE 45147 Essen
    Z Kinder Jugendpsychiatr Psychother 34:425-33. 2006
    ..The understanding of ADHD's neurobiology may be advanced by new technologies, such as SNP-based genome scans performed with gene chips comprising 10,000-1,000,000 SNPs, as well as using more sophisticated animal model designs...
  77. ncbi request reprint Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations
    Marta Ribases
    Genes and Disease Program, Center for Genomic Regulation, Barcelona Biomedical Research Park, Barcelona, Spain
    Hum Mol Genet 13:1205-12. 2004
    ..These are the first two variants associated with the pathophysiology of ED in different populations and support a role for BDNF in the susceptibility to aberrant eating behaviors...