Axel M Hillmer

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. pmc Genome-wide scan and fine-mapping linkage study of androgenetic alopecia reveals a locus on chromosome 3q26
    Axel M Hillmer
    Department of Genomics, Life and Brain Center, University of Bonn, D 53127 Bonn, Germany
    Am J Hum Genet 82:737-43. 2008
  2. doi Susceptibility variants for male-pattern baldness on chromosome 20p11
    Axel M Hillmer
    Department of Genomics, Life and Brain Center, University of Bonn, D 53127 Bonn, Germany
    Nat Genet 40:1279-81. 2008
  3. pmc Recent positive selection of a human androgen receptor/ectodysplasin A2 receptor haplotype and its relationship to male pattern baldness
    Axel M Hillmer
    Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
    Hum Genet 126:255-64. 2009
  4. doi Androgenetic alopecia: identification of four genetic risk loci and evidence for the contribution of WNT signaling to its etiology
    Stefanie Heilmann
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    J Invest Dermatol 133:1489-96. 2013
  5. pmc Genome-wide pooling approach identifies SPATA5 as a new susceptibility locus for alopecia areata
    Lina M Forstbauer
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Eur J Hum Genet 20:326-32. 2012
  6. pmc Genetic variation in the human androgen receptor gene is the major determinant of common early-onset androgenetic alopecia
    Axel M Hillmer
    Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
    Am J Hum Genet 77:140-8. 2005
  7. ncbi The two most common alleles of the coding GGN repeat in the androgen receptor gene cause differences in protein function
    Felix F Brockschmidt
    Department of Genomics, Life and Brain Center, University of Bonn, Sigmund Freud Strasse 25, 53127 Bonn, Germany
    J Mol Endocrinol 39:1-8. 2007
  8. ncbi Loss-of-function mutations in the filaggrin gene and alopecia areata: strong risk factor for a severe course of disease in patients comorbid for atopic disease
    Regina C Betz
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    J Invest Dermatol 127:2539-43. 2007
  9. pmc Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia
    Johannes Schumacher
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Am J Hum Genet 78:52-62. 2006
  10. doi G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth
    Sandra M Pasternack
    Institute of Human Genetics, University of Bonn, Bonn 53111, Germany
    Nat Genet 40:329-34. 2008

Collaborators

Detail Information

Publications10

  1. pmc Genome-wide scan and fine-mapping linkage study of androgenetic alopecia reveals a locus on chromosome 3q26
    Axel M Hillmer
    Department of Genomics, Life and Brain Center, University of Bonn, D 53127 Bonn, Germany
    Am J Hum Genet 82:737-43. 2008
    ..97 (empirical p value = 0.00055). This is the first step toward the identification of new susceptibility genes in AGA, a process which will provide important insights into the molecular and cellular basis of scalp hair loss...
  2. doi Susceptibility variants for male-pattern baldness on chromosome 20p11
    Axel M Hillmer
    Department of Genomics, Life and Brain Center, University of Bonn, D 53127 Bonn, Germany
    Nat Genet 40:1279-81. 2008
    ..7 x 10(-15)). No interaction was detected with the X-chromosomal androgen receptor locus, suggesting that the 20p11 locus has a role in a yet-to-be-identified androgen-independent pathway...
  3. pmc Recent positive selection of a human androgen receptor/ectodysplasin A2 receptor haplotype and its relationship to male pattern baldness
    Axel M Hillmer
    Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
    Hum Genet 126:255-64. 2009
    ..It is therefore probable that the AGA risk haplotype rose to high frequency in combination with this EDA2R variant, possibly by hitchhiking on a positively selected 57K haplotype...
  4. doi Androgenetic alopecia: identification of four genetic risk loci and evidence for the contribution of WNT signaling to its etiology
    Stefanie Heilmann
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    J Invest Dermatol 133:1489-96. 2013
    ..Expression studies in human hair follicle tissue suggest that WNT10A has a functional role in AGA etiology. Thus, our study provides genetic evidence supporting an involvement of WNT signaling in AGA development...
  5. pmc Genome-wide pooling approach identifies SPATA5 as a new susceptibility locus for alopecia areata
    Lina M Forstbauer
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Eur J Hum Genet 20:326-32. 2012
    ..43 × 10(-4) (OR=1.24 (1.10-1.39)). This SNP maps to an intronic region of the SPATA5 (spermatogenesis-associated protein 5) gene on chromosome 4. The results therefore suggest the SPATA5 locus is a new susceptibility locus for AA...
  6. pmc Genetic variation in the human androgen receptor gene is the major determinant of common early-onset androgenetic alopecia
    Axel M Hillmer
    Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
    Am J Hum Genet 77:140-8. 2005
    ..The X-chromosomal location of AR stresses the importance of the maternal line in the inheritance of AGA...
  7. ncbi The two most common alleles of the coding GGN repeat in the androgen receptor gene cause differences in protein function
    Felix F Brockschmidt
    Department of Genomics, Life and Brain Center, University of Bonn, Sigmund Freud Strasse 25, 53127 Bonn, Germany
    J Mol Endocrinol 39:1-8. 2007
    ..In conclusion, our data provide evidence of functional differences between the two most common alleles of the AR GGN repeat, supporting its potential role in the development of human traits...
  8. ncbi Loss-of-function mutations in the filaggrin gene and alopecia areata: strong risk factor for a severe course of disease in patients comorbid for atopic disease
    Regina C Betz
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    J Invest Dermatol 127:2539-43. 2007
    ..003; odds ratio (OR)=5.47 (95% confidence interval (CI): 1.59-18.76)). In conclusion, our data suggest that when AA occurs in conjunction with FLG-associated atopic disorder, the clinical presentation of AA may be more severe...
  9. pmc Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia
    Johannes Schumacher
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Am J Hum Genet 78:52-62. 2006
    ....
  10. doi G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth
    Sandra M Pasternack
    Institute of Human Genetics, University of Bonn, Bonn 53111, Germany
    Nat Genet 40:329-34. 2008
    ..This finding may provide opportunities for new therapeutic approaches to the treatment of hair loss in humans...