Jens Hillengass

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. pmc Changes in magnetic resonance imaging before and after autologous stem cell transplantation correlate with response and survival in multiple myeloma
    Jens Hillengass
    Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany
    Haematologica 97:1757-60. 2012
  2. doi request reprint [Multiple myeloma: current recommendations for imaging]
    J Hillengass
    Abteilung für Hämatologie, Onkologie und Rheumatologie, Medizinische Universitatsklinik, Im Neuenheimer Feld 410, 69120, Heidelberg, Deutschland
    Radiologe 52:360-5. 2012
  3. doi request reprint Monoclonal gammopathy and smoldering multiple myeloma: diagnosis, staging, prognosis, management
    Jens Hillengass
    Department of Medicine V, University of Heidelberg, Heidelberg, Germany
    Recent Results Cancer Res 183:113-31. 2011
  4. doi request reprint Diffusion-weighted imaging for non-invasive and quantitative monitoring of bone marrow infiltration in patients with monoclonal plasma cell disease: a comparative study with histology
    Jens Hillengass
    Department of Haematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany
    Br J Haematol 153:721-8. 2011
  5. doi request reprint Prognostic significance of focal lesions in whole-body magnetic resonance imaging in patients with asymptomatic multiple myeloma
    Jens Hillengass
    Department of Hematology and Oncology, University Hospital Heidelberg, Heidelberg, Germany
    J Clin Oncol 28:1606-10. 2010
  6. doi request reprint Dynamic contrast-enhanced magnetic resonance imaging identifies a subgroup of patients with asymptomatic monoclonal plasma cell disease and pathologic microcirculation
    Jens Hillengass
    German Cancer Research Center, Department of Radiology University of Heidelberg, Department of Hematology, Oncology and Rheumatology, Heidelberg, Germany
    Clin Cancer Res 15:3118-25. 2009
  7. doi request reprint Clinical evidence for immunomodulation induced by high-dose melphalan and autologous blood stem cell transplantation as cause for complete clinical remission of multiple myeloma-associated cryoglobulin-vasculitis
    J Hillengass
    Department of Hematology, University Hospital of Heidelberg, Heidelberg, Germany
    Int J Hematol 88:454-6. 2008
  8. ncbi request reprint Lumbar bone marrow microcirculation measurements from dynamic contrast-enhanced magnetic resonance imaging is a predictor of event-free survival in progressive multiple myeloma
    Jens Hillengass
    Department of Hematology, Oncology, and Rheumatology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Clin Cancer Res 13:475-81. 2007
  9. pmc Inhibition of aurora kinases for tailored risk-adapted treatment of multiple myeloma
    Dirk Hose
    Medizinische Klinik V, Universitatsklinikum Heidelberg, Heidelberg, Germany
    Blood 113:4331-40. 2009
  10. doi request reprint Chromosomal aberrations +1q21 and del(17p13) predict survival in patients with recurrent multiple myeloma treated with lenalidomide and dexamethasone
    Ulrike Klein
    Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany
    Cancer 117:2136-44. 2011

Collaborators

Detail Information

Publications34

  1. pmc Changes in magnetic resonance imaging before and after autologous stem cell transplantation correlate with response and survival in multiple myeloma
    Jens Hillengass
    Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany
    Haematologica 97:1757-60. 2012
    ..We suggest that residual disease after high-dose chemotherapy detected by magnetic resonance imaging increases the risk of relapse. Therefore, myeloma patients with such findings after treatment might benefit from further cytoreduction...
  2. doi request reprint [Multiple myeloma: current recommendations for imaging]
    J Hillengass
    Abteilung für Hämatologie, Onkologie und Rheumatologie, Medizinische Universitatsklinik, Im Neuenheimer Feld 410, 69120, Heidelberg, Deutschland
    Radiologe 52:360-5. 2012
    ..e., osteoporosis or bone destruction. Diffuse or circumscribed bone marrow infiltration without damage to mineralized bone is so far not regarded as end organ damage...
  3. doi request reprint Monoclonal gammopathy and smoldering multiple myeloma: diagnosis, staging, prognosis, management
    Jens Hillengass
    Department of Medicine V, University of Heidelberg, Heidelberg, Germany
    Recent Results Cancer Res 183:113-31. 2011
    ..Future studies are required to combine increasing knowledge on risk factors and molecular pathogenesis with targeted agents to prevent progression...
  4. doi request reprint Diffusion-weighted imaging for non-invasive and quantitative monitoring of bone marrow infiltration in patients with monoclonal plasma cell disease: a comparative study with histology
    Jens Hillengass
    Department of Haematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany
    Br J Haematol 153:721-8. 2011
    ....
  5. doi request reprint Prognostic significance of focal lesions in whole-body magnetic resonance imaging in patients with asymptomatic multiple myeloma
    Jens Hillengass
    Department of Hematology and Oncology, University Hospital Heidelberg, Heidelberg, Germany
    J Clin Oncol 28:1606-10. 2010
    ..In this study, we investigated the prognostic significance of FLs in wb-MRI in patients with asymptomatic multiple myeloma (aMM)...
  6. doi request reprint Dynamic contrast-enhanced magnetic resonance imaging identifies a subgroup of patients with asymptomatic monoclonal plasma cell disease and pathologic microcirculation
    Jens Hillengass
    German Cancer Research Center, Department of Radiology University of Heidelberg, Department of Hematology, Oncology and Rheumatology, Heidelberg, Germany
    Clin Cancer Res 15:3118-25. 2009
    ....
  7. doi request reprint Clinical evidence for immunomodulation induced by high-dose melphalan and autologous blood stem cell transplantation as cause for complete clinical remission of multiple myeloma-associated cryoglobulin-vasculitis
    J Hillengass
    Department of Hematology, University Hospital of Heidelberg, Heidelberg, Germany
    Int J Hematol 88:454-6. 2008
    ..While clinical symptoms of vasculitis disappeared, elevated cryoglobulin levels persisted. Therefore we conclude that the relief of symptoms was caused by an immunomodulation induced by the autologous stem cell transplantation...
  8. ncbi request reprint Lumbar bone marrow microcirculation measurements from dynamic contrast-enhanced magnetic resonance imaging is a predictor of event-free survival in progressive multiple myeloma
    Jens Hillengass
    Department of Hematology, Oncology, and Rheumatology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Clin Cancer Res 13:475-81. 2007
    ..In this study, the prognostic value of the DCE-MRI variables for overall survival and event-free survival in patients with progressive multiple myeloma was investigated...
  9. pmc Inhibition of aurora kinases for tailored risk-adapted treatment of multiple myeloma
    Dirk Hose
    Medizinische Klinik V, Universitatsklinikum Heidelberg, Heidelberg, Germany
    Blood 113:4331-40. 2009
    ..Using gene expression profiling, aurora kinase inhibitors as a promising therapeutic option in myeloma can be tailoredly given to patients expressing aurora-A, who in turn have an adverse prognosis...
  10. doi request reprint Chromosomal aberrations +1q21 and del(17p13) predict survival in patients with recurrent multiple myeloma treated with lenalidomide and dexamethasone
    Ulrike Klein
    Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany
    Cancer 117:2136-44. 2011
    ..In the era of novel agents such as lenalidomide and bortezomib, risk stratification by chromosomal abnormalities may enable a more rational selection of therapeutic approaches in patients with multiple myeloma (MM)...
  11. doi request reprint Autologous retransplantation for patients with recurrent multiple myeloma: a single-center experience with 200 patients
    Leopold Sellner
    Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany
    Cancer 119:2438-46. 2013
    ..Therapeutic options for patients with recurrent multiple myeloma after autologous stem cell transplantation (ASCT) include novel agents, conventional chemotherapy, or salvage ASCT with no standard of care...
  12. doi request reprint Progression in smoldering myeloma is independently determined by the chromosomal abnormalities del(17p), t(4;14), gain 1q, hyperdiploidy, and tumor load
    Kai Neben
    Kai Neben, Anna Jauch, Jens Hillengass, Nicola Lehners, Martin Granzow, Marc S Raab, and Anthony D Ho, University of Heidelberg Thomas Hielscher, German Cancer Research Center and Anja Seckinger, Hartmut Goldschmidt, and Dirk Hose, University of Heidelberg and National Center for Tumor Diseases, Heidelberg, Germany
    J Clin Oncol 31:4325-32. 2013
    ..The aim of this study was to analyze chromosomal aberrations in terms of frequency and impact on time to progression in patients with smoldering multiple myeloma (SMM) on the background of clinical prognostic factors...
  13. pmc Proliferation is a central independent prognostic factor and target for personalized and risk-adapted treatment in multiple myeloma
    Dirk Hose
    Medizinische Klinik V, Universitatsklinikum Heidelberg, Im Neuenheimer Feld, Heidelberg, Germany
    Haematologica 96:87-95. 2011
    ..Proliferation of malignant plasma cells is a strong adverse prognostic factor in multiple myeloma and simultaneously targetable by available (e.g. tubulin polymerase inhibitors) and upcoming (e.g. aurora kinase inhibitors) compounds...
  14. doi request reprint Intravoxel incoherent motion imaging for assessment of bone marrow infiltration of monoclonal plasma cell diseases
    Rajiv Shah
    German Cancer Research Center, Heidelberg, Germany
    Ann Hematol 92:1553-7. 2013
    ..g., monoclonal protein, hemoglobin, and immunoparesis. In summary, we found that the non-invasively acquired imaging parameters correlated with the degree of plasma cell infiltration in the bone marrow. ..
  15. doi request reprint Staging monoclonal plasma cell disease: comparison of the Durie-Salmon and the Durie-Salmon PLUS staging systems
    Kerstin Fechtner
    Department of Diagnostic and Interventional Radiology, University Hospital of Heidelberg, Im Neuenheimer Feld 110, Heidelberg, Germany
    Radiology 257:195-204. 2010
    ..To investigate the concordance of the Durie-Salmon staging system with the Durie-Salmon PLUS staging system in monoclonal plasma cell disease...
  16. ncbi request reprint Dynamic contrast-enhanced MRI for assessing the disease activity of multiple myeloma: a comparative study with histology and clinical markers
    Sílvia Nosàs-Garcia
    Department of Radiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    J Magn Reson Imaging 22:154-62. 2005
    ..To examine whether parameters of dynamic, contrast-enhanced MRI (DCE MRI) reflect the degree of infiltration and vessel density in corresponding bone marrow biopsy specimens...
  17. doi request reprint Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted imaging of bone marrow in healthy individuals
    Jens Hillengass
    Department of Radiology, German Cancer Research Center, Heidelberg, Germany
    Acta Radiol 52:324-30. 2011
    ..Recently published examples cover breast cancer, CNS tumors, head and neck cancer, gastrointestinal cancer, prostate cancer as well as hematologic malignancies...
  18. pmc Combining information regarding chromosomal aberrations t(4;14) and del(17p13) with the International Staging System classification allows stratification of myeloma patients undergoing autologous stem cell transplantation
    Kai Neben
    Department of Internal Medicine V, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Haematologica 95:1150-7. 2010
    ..Specific changes in interphase cells can be detected by fluorescent in situ hybridization, which overcomes the problem of the lack of dividing cells required for conventional cytogenetics...
  19. doi request reprint Parametric histogram analysis of dynamic contrast-enhanced MRI in multiple myeloma: a technique to evaluate angiogenic response to therapy?
    Christian M Zechmann
    Department of Radiology, German Cancer Research Center, Heidelberg, Germany
    Acad Radiol 19:100-8. 2012
    ..The purpose of this study was to evaluate histogram analysis of dynamic contrast-enhanced magnetic resonance imaging in MM to monitor early treatment response on the basis of microcirculation patterns...
  20. doi request reprint Multiple myeloma and monoclonal gammopathy of undetermined significance: importance of whole-body versus spinal MR imaging
    Tobias Bauerle
    Department of Radiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Radiology 252:477-85. 2009
    ..To examine if standard magnetic resonance (MR) imaging of the axial skeleton is sufficient for evaluation of patients with multiple myeloma (MM) or monoclonal gammopathy of undetermined significance (MGUS) or if whole-body MR is necessary...
  21. doi request reprint Clinical and prognostic role of annexin A2 in multiple myeloma
    Anja Seckinger
    Medizinische Klinik V, Universitatsklinikum Heidelberg, Heidelberg, Germany
    Blood 120:1087-94. 2012
    ..ANXA2 exemplifies an interesting class of targetable bone-remodeling factors expressed by normal and malignant plasma cells and the BM microenvironment that have a significant impact on survival of myeloma patients...
  22. ncbi request reprint Induction of angiogenesis by normal and malignant plasma cells
    Dirk Hose
    Medizinische Klinik V, Universitatsklinikum Heidelberg, Heidelberg, Germany
    Blood 114:128-43. 2009
    ..Aberrant expression of proangiogenic and down-regulation of antiangiogenic genes by MMCs further increases the angiogenic stimulus, together leading to bone marrow angiogenesis at various degrees in all myeloma patients...
  23. ncbi request reprint Sensitivity of whole-body CT and MRI versus projection radiography in the detection of osteolyses in patients with monoclonal plasma cell disease
    Maya B Wolf
    Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg Germany Department of Radiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany Electronic address
    Eur J Radiol 83:1222-30. 2014
    ....
  24. doi request reprint Effective prophylaxis of thromboembolic complications with low molecular weight heparin in relapsed multiple myeloma patients treated with lenalidomide and dexamethasone
    Ulrike Klein
    Department of Internal Medicine V, University of Heidelberg, INF 410, 69120 Heidelberg, Germany
    Ann Hematol 88:67-71. 2009
    ..Therefore, we propose LMWH should be used in patients being treated with lenalidomide and dexamethasone at least for the first 3 months of treatment until randomized trials have proven the equality of other pharmacological prophylaxis...
  25. doi request reprint Gain of 1q21 and distinct adverse cytogenetic abnormalities correlate with increased microcirculation in multiple myeloma
    Jens Hillengass
    Department of Hematology, Oncology, and Rheumatology, University of Heidelberg, Heidelberg, Germany
    Int J Cancer 122:2871-5. 2008
    ..Our findings will have important implications for the design, analysis and stratification for clinical studies of patients with MM in particular if compounds with antiangiogenic activity are used...
  26. doi request reprint Quantitative assessment of microcirculation and diffusion in the bone marrow of osteoporotic rats using VCT, DCE-MRI, DW-MRI, and histology
    Yifei Liu
    Department of Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany
    Acta Radiol 54:205-13. 2013
    ..Etiologic and pathophysiologic role of functional bone marrow processes is not fully understood especially in the case of osteoporosis...
  27. ncbi request reprint Clinical outcome of patients with follicular lymphoma and bulky disease after rituximab-CHOP immunochemotherapy with and without consolidating radiotherapy
    Fabienne McClanahan
    Department of Internal Medicine V, University Hospital of Heidelberg, Heidelberg, Germany
    Eur J Haematol 85:11-9. 2010
    ..The strategy to apply involved-field radiotherapy (IF-RT) after immunochemotherapy in patients with bulky follicular lymphoma (FL) remains controversial...
  28. doi request reprint Osteoporosis influences osteogenic but not angiogenic response during bone defect healing in a rat model
    Yifei Liu
    Department of Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany
    Injury 44:923-9. 2013
    ..This study provides insight into the relationship between angiogenesis and osteogenesis during osteoporosis-related compromised bone healing...
  29. ncbi request reprint Infiltration patterns in monoclonal plasma cell disorders: correlation of magnetic resonance imaging with matched bone marrow histology
    Mindaugas Andrulis
    Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Eur J Radiol 83:970-4. 2014
    ..To investigate how plasma cell infiltration patterns detected by MRI match the plasma cell distribution in bone marrow biopsy...
  30. ncbi request reprint Where is the primary tumour?
    Christian M Zechmann
    Department of Radiology, German Cancer Research Centre DKFZ, Heidelberg, Germany
    Lancet 370:1800. 2007
  31. doi request reprint Kyphoplasty in patients with multiple myeloma a retrospective comparative pilot study
    Christian Kasperk
    Department of Medicine I and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany
    J Surg Oncol 105:679-86. 2012
    ..This retrospective study of 73 myeloma patients with painful vertebral lesions compares clinical and radiomorphological outcomes up to 2 years after additional kyphoplasty, radiation therapy or systemic treatment only...
  32. ncbi request reprint Challenges and opportunities of novel imaging techniques in monoclonal plasma cell disorders: imaging "early myeloma"
    Jens Hillengass
    Department of Hematology, Oncology and Rheumatology, University of Heidelberg, Heidelberg, Germany
    Leuk Lymphoma 54:1355-63. 2013
    ..The present review summarizes data on novel imaging techniques and discusses their clinical value and future opportunities for patients with monoclonal plasma cell diseases...
  33. ncbi request reprint Radiotherapy of solitary plasmacytoma
    Sonja Krause
    Department of Radiation Oncology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Ann Hematol 90:1093-7. 2011
    ..Radiotherapy can achieve excellent local control of solitary plasmacytoma. Progression to multiple myeloma, especially in the case of SBP, remains to be addressed by further studies...
  34. doi request reprint A quantification strategy for missing bone mass in case of osteolytic bone lesions
    Andrea Fränzle
    Department of Medical Physics in Radiation Oncology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Med Phys 40:123501. 2013
    ..Here, the authors present an automated segmentation method for the measurement of missing bone mass in a preclinical rat model with bone metastases in the hind leg bones based on 3D CT scans...