Research Topics
Genomes and Genes | S HiendlederSummaryAffiliation: University of Munich Country: Germany Publications
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Publications
Mitochondria and the success of somatic cell nuclear transfer cloning: from nuclear-mitochondrial interactions to mitochondrial complementation and mitochondrial DNA recombinationStefan Hiendleder
Institute of Molecular Animal Breeding and Biotechnology, Gene Center of the Ludwig Maximilian University, D 81377 Munich, Germany
Reprod Fertil Dev 17:69-83. 2005..Furthermore, we indicate pathways that could link epigenetic reprogramming and mitochondria effects in SCNT and address questions and perspectives for future research...
Tissue-specific elevated genomic cytosine methylation levels are associated with an overgrowth phenotype of bovine fetuses derived by in vitro techniquesStefan Hiendleder
Department of Molecular Animal Breeding and Biotechnology, Gene Center of the Ludwig Maximilian University, D 1377 Munich, Germany
Biol Reprod 71:217-23. 2004....
Mapping of QTL for Body Conformation and Behavior in CattleS Hiendleder
Institut für Tierzucht und Haustiergenetik der Justus Liebig Universität, D 35390 Giessen, Germany
J Hered 94:496-506. 2003..This study provides the first evidence for QTL involved in behavior of dairy cattle and identifies QTL for udder conformation on chromosome 6 that could form the basis of recently reported QTL for clinical mastitis...
Heteroplasmy in bovine fetuses produced by intra- and inter-subspecific somatic cell nuclear transfer: neutral segregation of nuclear donor mitochondrial DNA in various tissues and evidence for recipient cow mitochondria in fetal bloodStefan Hiendleder
Department of Molecular Animal Breeding and Biotechnology, Ludwig Maximilian University, D 85764 Oberschleissheim, Germany
Biol Reprod 68:159-66. 2003..primigenius) subspecies. Detection of mtDNA from the recipient animal in the circulation of two fetuses points to leakage of the placental barrier, mimicking heteroplasmy...
SNPs in the porcine INHA gene and linkage mapping to SSC15S Hiendleder
Department of Animal Breeding and Genetics, Justus-Liebig-University, Giessen, Germany
Anim Genet 33:247-8. 2002
Molecular analysis of wild and domestic sheep questions current nomenclature and provides evidence for domestication from two different subspeciesStefan Hiendleder
Department of Animal Breeding and Genetics, Justus Liebig University, Ludwigstr 21b, D 35390 Giessen, Germany
Proc Biol Sci 269:893-904. 2002..orientalis species, but belong to different clades. Furthermore, Ust-Urt sheep could be a hybrid population or an O. ammon subspecies closely related to O. ammon nigrimontana...
The complete mitochondrial DNA sequence of the domestic sheep (Ovis aries) and comparison with the other major ovine haplotypeS Hiendleder
Department of Animal Breeding and Genetics, Justus Liebig University, Ludwigstr 21b, D 35390 Giessen, Germany
J Mol Evol 47:441-8. 1998..indicus and B. taurus cattle. Datings based on complete mtDNAs suggest that the bovine and ovine lineages diverged about 30 million years before present. This dating is considerably earlier than that proposed previously...
A low rate of replacement substitutions in two major Ovis aries mitochondrial genomesS Hiendleder
Department of Animal Breeding and Genetics, Justus Liebig University, Giessen, Germany
Anim Genet 29:116-22. 1998..Nucleotide substitutions with a potential for phenotypic effects were found in the 12S and 16S rRNA and in the ND1 and COIII genes...
Transmitochondrial differences and varying levels of heteroplasmy in nuclear transfer cloned cattleS Hiendleder
Department of Animal Breeding and Genetics, Justus Liebig University, Giessen, Germany
Mol Reprod Dev 54:24-31. 1999..These results suggest that mtDNA type of donor embryos and recipient oocytes used in nuclear transfer cattle cloning should be controlled to obtain true clones with identical nuclear and cytoplasmic genomes...
Complete mitochondrial genomes of Bos taurus and Bos indicus provide new insights into intra-species variation, taxonomy and domesticationS Hiendleder
Department of Molecular Animal Breeding and Biotechnology, Gene Center of the Ludwig Maximilian University, Munchen, Germany
Cytogenet Genome Res 120:150-6. 2008..taurus cluster. These data suggest domestications from several differentiated populations of B. primigenius and a subspecies status for taurine (B. primigenius taurus) and zebuine (B. primigenius indicus) cattle...
Analysis of mitochondrial DNA indicates that domestic sheep are derived from two different ancestral maternal sources: no evidence for contributions from urial and argali sheepS Hiendleder
Department of Animal Breeding and Genetics, Justus Liebig University, Giessen, Germany
J Hered 89:113-20. 1998....
Rapid communication: a single-strand conformation polymorphism in the ovine interleukin-2 (IL-2) geneG Luhken
Department of Animal Breeding and Genetics, Justus Liebig University, Giessen, Germany
J Anim Sci 78:2754-5. 2000
Tissue-specific effects of in vitro fertilization procedures on genomic cytosine methylation levels in overgrown and normal sized bovine fetusesStefan Hiendleder
Institute of Molecular Animal Breeding and Biotechnology, Gene Center of the Ludwig Maximilian University, D 81377 Munich, and Pediatric Endocrinology Section, University Hospital, Tuebingen, Germany
Biol Reprod 75:17-23. 2006..Our data indicate that bovine IVF procedures can affect fetal genomic 5mC levels in a protocol- and tissue-specific manner and show that hepatic hypermethylation is associated with fetal overgrowth and its correlated endocrine changes...
Linkage mapping of the ovine alpha-inhibin (INHA) beta(A)-inhibin/activin (INHBA) and beta(B)-inhibin/activin (INHBB) genesS Hiendleder
Department of Animal Breeding and Genetics, Justus Liebig University, Giessen, Germany
J Hered 91:343-5. 2000....
Bovine somatic cell nuclear transfer using recipient oocytes recovered by ovum pick-up: effect of maternal lineage of oocyte donorsKatja Brüggerhoff
Department of Molecular Animal Breeding and Biotechnology, Ludwig Maximilian University, D 85764 Oberschleissheim, Germany
Biol Reprod 66:367-73. 2002..These will be valuable tools to experimentally dissect the effects of nuclear and cytoplasmic components on embryonic, fetal, and postnatal development...
[Methods for transcriptome and proteome research: applications for studying the biology of reproduction in cattle]Eckhard Wolf
Lehrstuhl für MolekulareTierzucht und Biotechnologie, Ludwig Maximilians Universitat Munchen
Berl Munch Tierarztl Wochenschr 119:7-16. 2006..This review provides an overview of the most important strategies for holistic transcriptome and proteome analyses. The successful application of these techniques is exemplified by our studies of bovine reproductive biology...
Maternal-fetal transplacental leakage of mitochondrial DNA in bovine nuclear transfer pregnancies: potential implications for offspring and recipientsStefan Hiendleder
Department of Molecular Animal Breeding and Biotechnology, Gene Center of the Ludwig Maximilian University, Munich, Germany
Cloning Stem Cells 6:150-6. 2004..e. whether leakage takes place in vivo. If recipients were chimeric for DNA or cells derived from genetically modified SCNT (or IVF) embryos, their subsequent utilization might be affected...
Nuclear-cytoplasmic interactions affect in utero developmental capacity, phenotype, and cellular metabolism of bovine nuclear transfer fetusesStefan Hiendleder
Department of Molecular Animal Breeding and Biotechnology, Gene Center of the Ludwig Maximilian University, D 81377 Munich, Germany
Biol Reprod 70:1196-205. 2004....
Functional genomics: tools for improving farm animal health and welfareS Hiendleder
Institute of Molecular Animal Breeding and Biotechnology, Gene Center of the Ludwig-Maximilian University, Feodor-Lynen-Strasse 25, 81377 Munich, Germany
Rev Sci Tech 24:355-77. 2005..This review describes major functional genomics tools, lists genomic resources available for farm animals and discusses the prospects and challenges of functional genomics in improving the health and welfare of farm animals...
Molecular genetic characterization of new bovine kappa-casein alleles CSN3F and CSN3G and genotyping by PCR-RFLPE M Prinzenberg
Department of Animal Breeding and Genetics, Justus Liebig University, Giessen, Germany
Anim Genet 27:347-9. 1996..A PCR-restriction fragment length polymorphism (RFLP) genotyping procedure for all currently known CSN3 alleles (CSN3A, CSN3B, CSN3C, CSN3E, CSN3F, CSN3G) was developed...
A bovine oviduct epithelial cell suspension culture system suitable for studying embryo-maternal interactions: morphological and functional characterizationRegine Rottmayer
Institute of Molecular Animal Breeding and Biotechnology, Gene Center of the Ludwig-Maximilians University Munich, Munich, Germany
Reproduction 132:637-48. 2006..Our novel culture system provides functional BOECs in sufficient quantities for holistic transcriptome and proteome studies, e.g. for deciphering early embryo-maternal communication...
Nucleotide sequence and variation of IGF2 gene exon 6 in Bos taurus and Bos indicus cattleKrzysztof Flisikowski
Institute of Genetics and Animal Breeding, Jastrzebiec, 05 552 Wolka Kosowska, Poland
Anim Biotechnol 16:203-8. 2005..A comparative analysis was performed for this fragment from different species; 99.5% identity was found between Bos taurus and Bos indicus cattle...
Combined analysis of data from two granddaughter designs: A simple strategy for QTL confirmation and increasing experimental power in dairy cattleJörn Bennewitz
Institut für Tierzucht und Tierhaltung, Christian Albrechts Universitat, 24098 Kiel, Germany
Genet Sel Evol 35:319-38. 2003..This study demonstrated the potential benefits of a combined analysis of data from different granddaughter designs...
Mitochondrial DNA inheritance after SCNTStefan Hiendleder
Department of Animal Science, The University of Adelaide, Roseworthy Campus, Roseworthy, South Australia 5371, Australia
Adv Exp Med Biol 591:103-16. 2007....
