C Hiemke

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. ncbi request reprint Automated determination of ziprasidone by HPLC with column switching and spectrophotometric detection
    Julia Sachse
    Department of Psychiatry, University of Mainz, Untere Zahlbacherstrasse 8, D 55131 Mainz, Germany
    Ther Drug Monit 27:158-62. 2005
  2. ncbi request reprint Therapeutic monitoring of new antipsychotic drugs
    Christoph Hiemke
    Department of Psychiatry, University of Mainz, D 55101 Mainz, Germany
    Ther Drug Monit 26:156-60. 2004
  3. doi request reprint [Individualized treatment with tricyclic antidepressives. The pharmacogenetics of depression]
    Christoph Hiemke
    Klinik fur Psychiatrie und Psychotherapie, Johannes Gutenberg Universitat Mainz, Untere Zahlbacher Str 8, 55131 Mainz
    Pharm Unserer Zeit 37:234-40. 2008
  4. doi request reprint Clinical utility of drug measurement and pharmacokinetics: therapeutic drug monitoring in psychiatry
    Christoph Hiemke
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Eur J Clin Pharmacol 64:159-66. 2008
  5. doi request reprint Therapeutic drug monitoring in neuropsychopharmacology: does it hold its promises?
    Christoph Hiemke
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Str 8, Mainz, Germany
    Eur Arch Psychiatry Clin Neurosci 258:21-7. 2008
  6. ncbi request reprint Pharmacokinetics of selective serotonin reuptake inhibitors
    C Hiemke
    Department of Psychiatry, University of Mainz, Germany
    Pharmacol Ther 85:11-28. 2000
  7. ncbi request reprint Prolactin plasma levels and D2-dopamine receptor occupancy measured with IBZM-SPECT
    S Schlegel
    Department of Psychiatry, University of Mainz, Germany
    Psychopharmacology (Berl) 124:285-7. 1996
  8. ncbi request reprint Addition of low-dose fluvoxamine to low-dose clozapine monotherapy in schizophrenia: drug monitoring and tolerability data from a prospective clinical trial
    A Szegedi
    Department of Psychiatry, University of Mainz, Germany
    Pharmacopsychiatry 32:148-53. 1999
  9. ncbi request reprint Plasma levels of benperidol, prolactin, and homovanillic acid after intravenous versus two different kinds of oral application of the neuroleptic in schizophrenic patients
    W Seiler
    Department of Psychiatry, University of Mainz, Germany
    Exp Clin Endocrinol 102:326-33. 1994
  10. ncbi request reprint Fluvoxamine but not sertraline inhibits the metabolism of olanzapine: evidence from a therapeutic drug monitoring service
    H Weigmann
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Ther Drug Monit 23:410-3. 2001

Collaborators

Detail Information

Publications93

  1. ncbi request reprint Automated determination of ziprasidone by HPLC with column switching and spectrophotometric detection
    Julia Sachse
    Department of Psychiatry, University of Mainz, Untere Zahlbacherstrasse 8, D 55131 Mainz, Germany
    Ther Drug Monit 27:158-62. 2005
    ..Forty to 130 ng/mL may be considered the recommended target plasma concentration range. HPLC with column switching and UV detection as described here is suitable for therapeutic drug monitoring of ziprasidone...
  2. ncbi request reprint Therapeutic monitoring of new antipsychotic drugs
    Christoph Hiemke
    Department of Psychiatry, University of Mainz, D 55101 Mainz, Germany
    Ther Drug Monit 26:156-60. 2004
    ..The few reported investigations, however, need to be confirmed and extended...
  3. doi request reprint [Individualized treatment with tricyclic antidepressives. The pharmacogenetics of depression]
    Christoph Hiemke
    Klinik fur Psychiatrie und Psychotherapie, Johannes Gutenberg Universitat Mainz, Untere Zahlbacher Str 8, 55131 Mainz
    Pharm Unserer Zeit 37:234-40. 2008
  4. doi request reprint Clinical utility of drug measurement and pharmacokinetics: therapeutic drug monitoring in psychiatry
    Christoph Hiemke
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Eur J Clin Pharmacol 64:159-66. 2008
    ..This would merely increase the amount of work and costs, as high-throughput methods are now available in many laboratories. Any progress in TDM has direct benefits for the treatment of many individual patients...
  5. doi request reprint Therapeutic drug monitoring in neuropsychopharmacology: does it hold its promises?
    Christoph Hiemke
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Str 8, Mainz, Germany
    Eur Arch Psychiatry Clin Neurosci 258:21-7. 2008
    ..Moreover, many drug interactions have been detected by using TDM. In conclusion, TDM is a reliable tool to optimise psychopharmacotherapy. When used adequately it is helpful for many psychiatric patients and in many situations...
  6. ncbi request reprint Pharmacokinetics of selective serotonin reuptake inhibitors
    C Hiemke
    Department of Psychiatry, University of Mainz, Germany
    Pharmacol Ther 85:11-28. 2000
    ....
  7. ncbi request reprint Prolactin plasma levels and D2-dopamine receptor occupancy measured with IBZM-SPECT
    S Schlegel
    Department of Psychiatry, University of Mainz, Germany
    Psychopharmacology (Berl) 124:285-7. 1996
    ..Prolactin levels were positively correlated with D2 receptor occupancy, reflecting at least in part a comparable dopamine receptor antagonism in different dopaminergic pathways...
  8. ncbi request reprint Addition of low-dose fluvoxamine to low-dose clozapine monotherapy in schizophrenia: drug monitoring and tolerability data from a prospective clinical trial
    A Szegedi
    Department of Psychiatry, University of Mainz, Germany
    Pharmacopsychiatry 32:148-53. 1999
    ..Further studies have to find out if the combined treatment could be advantageous to clozapine monotherapy...
  9. ncbi request reprint Plasma levels of benperidol, prolactin, and homovanillic acid after intravenous versus two different kinds of oral application of the neuroleptic in schizophrenic patients
    W Seiler
    Department of Psychiatry, University of Mainz, Germany
    Exp Clin Endocrinol 102:326-33. 1994
    ....
  10. ncbi request reprint Fluvoxamine but not sertraline inhibits the metabolism of olanzapine: evidence from a therapeutic drug monitoring service
    H Weigmann
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Ther Drug Monit 23:410-3. 2001
    ..Combination therapy of olanzapine and fluvoxamine should be used cautiously, and therapeutic drug monitoring should be instituted to avoid olanzapine-induced adverse effects or intoxications...
  11. doi request reprint Amisulpride doses and plasma levels in different age groups of patients with schizophrenia or schizoaffective disorder
    Matthias J Muller
    Department of Psychiatry, University of Mainz, Mainz, Germany
    J Psychopharmacol 23:278-86. 2009
    ....
  12. doi request reprint The serotonin transporter promoter polymorphism (5-HTTLPR) affects the relation between antidepressant serum concentrations and effectiveness in major depression
    N Dreimüller
    Department of Psychiatry and Psychotherapy, University Medical Centre, Mainz, Germany
    Pharmacopsychiatry 45:108-13. 2012
    ..Results, however, are inconsistent. The aim of this study was to investigate whether remission or response to SSRIs is influenced by an interaction of 5-HTTLPR and SSRI serum concentrations...
  13. ncbi request reprint Increased bioavailability of oral melatonin after fluvoxamine coadministration
    S Hartter
    Department of Psychiatry, University of Mainz, Germany
    Clin Pharmacol Ther 67:1-6. 2000
    ..It has not been clear whether these effects might be attributed to an increased melatonin production or to an decreased elimination of melatonin. The latter hypothesis was tested by this study...
  14. ncbi request reprint Serum levels of sulpiride enantiomers after oral treatment with racemic sulpiride in psychiatric patients: a pilot study
    M J Muller
    Department of Psychiatry, University of Mainz, Germany
    Pharmacopsychiatry 34:27-32. 2001
    ..66-0.97) in all patients. A slight negative correlation between CGI improvement and the ratio of L:D-SULP (p < 0.10) and a positive correlation between racemic SULP concentrations and side-effects at endpoint was found (p < 0.05)...
  15. ncbi request reprint [123I]IBZM SPECT in patients treated with typical and atypical neuroleptics: relationship to drug plasma levels and extrapyramidal side effects
    R Schlosser
    Department of Psychiatry, University of Mainz, Germany
    Psychiatry Res 75:103-14. 1997
    ..There was a negative continuous correlation between uptake of IBZM and extrapyramidal side effects, which is different from the threshold-based relationship between extrapyramidal side effects and IBZM uptake reported previously...
  16. ncbi request reprint Determination of benperidol and its reduced metabolite in human plasma by high-performance liquid chromatography and electrochemical detection
    S Suss
    Department of Psychiatry, University of Mainz, Germany
    J Chromatogr 565:363-73. 1991
    ..In plasma samples collected from a schizophrenic patient treated with a single oral dose of 6 mg of benperidol, plasma levels of benperidol and of the metabolite could be measured from 20 min to at least 12 h after administration...
  17. ncbi request reprint Pharmacokinetics and bioavailability of benperidol in schizophrenic patients after intravenous and two different kinds of oral application
    W Seiler
    Department of Psychiatry, University of Mainz, Germany
    Psychopharmacology (Berl) 116:457-63. 1994
    ..6% after liquid and 40.2% after tablet administration respectively. All parameters studied exhibited large intersubject variation. The plasma concentrations of the presumed metabolite "reduced benperidol" were found to be very low...
  18. ncbi request reprint CYP2D6 polymorphism and clinical effect of the antidepressant venlafaxine
    M E E Shams
    Department of Psychiatry, University of Mainz, Mainz, Germany
    J Clin Pharm Ther 31:493-502. 2006
    ..Objectives: The aim of this study was to assess whether the O-demethylation phenotype of V has an impact on the pharmacokinetics and clinical outcome...
  19. doi request reprint Early improvement and serum concentrations of citalopram to predict antidepressant drug response of patients with major depression
    E Ostad Haji
    Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Mainz, Germany
    Pharmacopsychiatry 46:261-6. 2013
    ....
  20. ncbi request reprint Simultaneous determination of olanzapine, clozapine and demethylated metabolites in serum by on-line column-switching high-performance liquid chromatography
    H Weigmann
    Department of Psychiatry, University of Mainz, Germany
    J Chromatogr B Biomed Sci Appl 759:63-71. 2001
    ..The limit of quantification was 10-20 ng/ml. Relative day to day standard variations ranged between 4.5 and 13.5%. The method is suitable for routine monitoring of olanzapine and clozapine including their demethylated metabolites...
  21. ncbi request reprint Gender aspects in the clinical treatment of schizophrenic inpatients with amisulpride: a therapeutic drug monitoring study
    M J Muller
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Pharmacopsychiatry 39:41-6. 2006
    ..However, to date no empirical evidence exists in support of this notion...
  22. doi request reprint The effect of age, sex, smoking and co-medication on serum levels of venlafaxine and O-desmethylvenlafaxine under naturalistic conditions
    S Unterecker
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Pharmacopsychiatry 45:229-35. 2012
    ..In this study we examined the influence of age, sex, smoking, and co-medication on serum levels of VEN and its metabolite O-desmethylvenlafaxine (ODVEN) in patients treated with VEN under naturalistic conditions...
  23. ncbi request reprint Therapeutic drug monitoring of tricyclic antidepressants: how does it work under clinical conditions?
    M J Muller
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Pharmacopsychiatry 36:98-104. 2003
    ..The results encourage further studies in order to optimize antidepressant pharmacotherapy when using TDM appropriately...
  24. ncbi request reprint Melperone is an inhibitor of the CYP2D6 catalyzed O-demethylation of venlafaxine
    M Grozinger
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Pharmacopsychiatry 36:3-6. 2003
    ..In an open pilot study, effects of melperone on the steady-state blood levels of venlafaxine, a recently introduced serotonin- and noradrenaline reuptake inhibiting antidepressant, were assessed...
  25. ncbi request reprint Relationship between mirtazapine dose, plasma concentration, response, and side effects in clinical practice
    K Grasmäder
    Department of Psychiatry, University of Bonn, Germany
    Pharmacopsychiatry 38:113-7. 2005
    ..The aim of this study was to evaluate the benefit of mirtazapine plasma concentration monitoring in a typical clinical setting...
  26. ncbi request reprint Differential effects of fluvoxamine and other antidepressants on the biotransformation of melatonin
    S Hartter
    Department of Psychiatry, University of Mainz, Germany
    J Clin Psychopharmacol 21:167-74. 2001
    ..Because this inhibitory action is also found in vivo, fluvoxamine might be used as an enhancer of melatonin, which might offer new therapeutic possibilities of fluvoxamine...
  27. ncbi request reprint Effects of GABA-transporter (GAT) inhibitors on rat behaviour in open-field and elevated plus-maze
    U Schmitt
    Department of Psychiatry, University of Mainz, Germany
    Behav Pharmacol 10:131-7. 1999
    ..SKF 89976-A exhibited minimal effects over the dose range tested. These results indicate that inhibition of GABA uptake might be a pharmacological strategy to treat not only epilepsy, but also anxiety disorders...
  28. doi request reprint Clozapine plasma level monitoring for prediction of rehospitalization schizophrenic outpatients
    V Stieffenhofer
    Department of Psychiatry and Psychotherapy, University Medical Center, Mainz, Germany
    Pharmacopsychiatry 44:55-9. 2011
    ..The aim of this naturalistic exploratory study was to examine whether blood antipsychotic drug concentrations can predict rehospitalizations in chronically medicated patients...
  29. ncbi request reprint Impact of polymorphisms of cytochrome-P450 isoenzymes 2C9, 2C19 and 2D6 on plasma concentrations and clinical effects of antidepressants in a naturalistic clinical setting
    Katja Grasmäder
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Eur J Clin Pharmacol 60:329-36. 2004
    ..Side effects and treatment response were analysed in an exploratory approach in poor and ultra-rapid metabolisers...
  30. ncbi request reprint Therapeutic drug monitoring for optimizing amisulpride therapy in patients with schizophrenia
    Matthias J Muller
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Str 8, D 55131 Mainz, Germany
    J Psychiatr Res 41:673-9. 2007
    ..Although our results were mainly explorative, TDM of amisulpride seems very useful for clinical decision making...
  31. ncbi request reprint The striatal and extrastriatal D2/D3 receptor-binding profile of clozapine in patients with schizophrenia
    Gerhard Grunder
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Neuropsychopharmacology 31:1027-35. 2006
    ..Extrastriatal binding of clozapine may be more relevant to its antipsychotic actions than striatal. However, further studies with an intraindividual comparison of untreated vs treated state are desirable to confirm this finding...
  32. doi request reprint The use of ziprasidone in clinical practice: analysis of pharmacokinetic and pharmacodynamic aspects from data of a drug monitoring survey
    Friederike Vogel
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Eur Psychiatry 24:143-8. 2009
    ..05) with doses or serum levels. It is concluded that TDM of ziprasidone may be useful for treatment optimization because of highly variable serum concentrations resulting under therapeutically recommended doses of the drug...
  33. doi request reprint Behavioural consequences of p-glycoprotein deficiency in mice, with special focus on stress-related mechanisms
    Y Schoenfelder
    Department of Psychiatry and Psychotherapy, University Medical Centre of the Johannes Gutenberg University Mainz, Mainz, Germany
    J Neuroendocrinol 24:809-17. 2012
    ..The results obtained in the present study demonstrate that a P-gp deficiency has an impact on the stress-related behaviour, possibly as a result of differences in HPA axis-feedback regulation...
  34. ncbi request reprint Cyclosporine A (CsA) affects the pharmacodynamics and pharmacokinetics of the atypical antipsychotic amisulpride probably via inhibition of P-glycoprotein (P-gp)
    U Schmitt
    Department of Psychiatry, University of Mainz, Mainz, Germany
    J Neural Transm 113:787-801. 2006
    ..16 vs 2.98 micromol h l(-1) for brain tissue) while renal clearance was not affected. These results pointed to a pharmacokinetic drug interaction between CsA and amisulpride most likely caused by inhibition of P-gp...
  35. doi request reprint Duloxetine serum concentrations and clinical effects. Data from a therapeutic drug monitoring (TDM) survey
    C Waldschmitt
    Department of Psychiatry and Psychotherapy, University of Mainz, Mainz, Germany
    Pharmacopsychiatry 42:189-93. 2009
    ..The aim of this study was to relate drug concentrations in serum and clinical effects in patients treated with the new antidepressant duloxetine...
  36. ncbi request reprint Long-term effects of the substituted benzamide derivative amisulpride on baseline and stimulated prolactin levels
    R Schlosser
    Department of Psychiatry, University of Mainz, Germany
    Neuropsychobiology 46:33-40. 2002
    ..However, the findings indicate also that treatment with amisulpride at clinically effective doses can be achieved at significantly lower prolactin levels during the long-term maintenance phase than during the prior acute phase...
  37. ncbi request reprint [Standardized documentation procedure as a basis for improvement of process quality of treatment in psychiatric hospitals]
    K Mann
    Psychiatrische Klinik der Universität Mainz
    Nervenarzt 74:235-44. 2003
    ..Moreover, in psychiatric care research, it is an adequate basis for evaluating the effectiveness and efficiency of treatment procedures...
  38. ncbi request reprint Rapid and reliable genotyping procedure for detection of alleles with mutations, deletion, or/and duplication of the CYP2D6 gene
    Borros Arneth
    Department of Clinical Chemistry, University of Mainz, Germany
    Clin Biochem 42:1282-90. 2009
    ..Therapeutic plasma levels of CYP2D6 substrates may be difficult to achieve. Here we describe a rapid and reliable procedure for CYP2D6*4, *3, *6, and *9 genotyping...
  39. ncbi request reprint Serum levels of aripiprazole and dehydroaripiprazole, clinical response and side effects
    Katrin M Kirschbaum
    Department of Psychiatry, University of Mainz, Germany
    World J Biol Psychiatry 9:212-8. 2008
    ....
  40. pmc Peripheral blood and neuropsychological markers for the onset of action of antidepressant drugs in patients with Major Depressive Disorder
    Andre Tadic
    Department of Psychiatry and Psychotherapy, University Medical Centre, Mainz, Germany
    BMC Psychiatry 11:16. 2011
    ..Peripheral blood markers and executive functions are particularly promising candidates as markers for the onset of action and thus the prediction of final treatment outcome in MDD...
  41. ncbi request reprint Over-expression of two different forms of the alpha-secretase ADAM10 affects learning and memory in mice
    Ulrich Schmitt
    Department of Psychiatry, Johannes Gutenberg University, 55101 Mainz, Germany
    Behav Brain Res 175:278-84. 2006
    ..Nevertheless, it could be concluded that both, ADAM10 and ADAM10-dn mice are suitable control mice for the assessment of alpha-secretase-related effects in animal models of Alzheimer's disease...
  42. ncbi request reprint Clinical improvement in a case of frontotemporal dementia under aripiprazole treatment corresponds to partial recovery of disturbed frontal glucose metabolism
    Andreas Fellgiebel
    Department of Psychiatry, University Hospital of Mainz, Mainz, Germany
    World J Biol Psychiatry 8:123-6. 2007
    ....
  43. ncbi request reprint Nocturnal hormone profiles in patients with schizophrenia treated with olanzapine
    Klaus Mann
    Department of Psychiatry, University of Mainz, Untere Zahibacher Strasse 8, Mainz D 55101, Germany
    Psychoneuroendocrinology 31:256-64. 2006
    ....
  44. ncbi request reprint Therapeutic monitoring of aripiprazole by HPLC with column-switching and spectrophotometric detection
    Katrin M Kirschbaum
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Clin Chem 51:1718-21. 2005
  45. ncbi request reprint Appropriateness of therapeutic drug monitoring for antidepressants in routine psychiatric inpatient care
    Klaus Mann
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Ther Drug Monit 28:83-8. 2006
    ....
  46. doi request reprint Cerebrospinal fluid tau protein levels and 18F-fluorodeoxyglucose positron emission tomography in the differential diagnosis of Alzheimer's disease
    Igor Yakushev
    Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Mainz, Germany
    Dement Geriatr Cogn Disord 30:245-53. 2010
    ....
  47. ncbi request reprint Tyrosine hydroxylase Val-81-Met polymorphism associated with early-onset alcoholism
    Norbert Dahmen
    Department of Psychiatry, University of Mainz, Germany
    Psychiatr Genet 15:13-6. 2005
    ..This effect was largely due to the association with early-onset alcoholism (77.8%), whereas no difference was noted between late-onset patients and controls. Our results suggest a role for tyrosine hydroxylase in early-onset alcoholism...
  48. pmc Rationale and design of the randomised clinical trial comparing early medication change (EMC) strategy with treatment as usual (TAU) in patients with major depressive disorder--the EMC trial
    Andre Tadic
    Department of Psychiatry and Psychotherapy, University Medical Centre Mainz, Germany
    Trials 11:21. 2010
    ..Even more important, non-improvement (HAMD decrease <20%) after 14 days of treatment was found to be highly predictive for a poor final treatment outcome...
  49. ncbi request reprint The N-demethylation of the doxepin isomers is mainly catalyzed by the polymorphic CYP2C19
    Sebastian Hartter
    Department of Psychiatry, University of Mainz, Germany
    Pharm Res 19:1034-7. 2002
    ....
  50. ncbi request reprint How does the benzamide antipsychotic amisulpride get into the brain?--An in vitro approach comparing amisulpride with clozapine
    Sebastian Hartter
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Neuropsychopharmacology 28:1916-22. 2003
    ..The permeation of AMS across the BBB was restricted partly due to an efflux transport. It is thus suggested that AMS reaches its target structures via transport across the blood-CSF barrier...
  51. ncbi request reprint [Therapeutic drug monitoring of new antidepressives and antipsychotics]
    Sebastian Hartter
    Neurochemisches Labor, Psychiatrische Klinik, Untere Zahlbacher Strasse 8, 55131 Mainz
    Med Monatsschr Pharm 26:160-2. 2003
  52. ncbi request reprint High striatal occupancy of D2-like dopamine receptors by amisulpride in the brain of patients with schizophrenia
    Ingo Vernaleken
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Int J Neuropsychopharmacol 7:421-30. 2004
    ..However, our data show high striatal D2-like receptor occupancies under rising plasma concentrations. Using the full range of recommended amisulpride dosage, striatal occupancies up to 90% can be measured...
  53. ncbi request reprint Quantification of D2-like dopamine receptors in the human brain with 18F-desmethoxyfallypride
    Gerhard Grunder
    Department of Psychiatry, University of Mainz, Mainz, Germany
    J Nucl Med 44:109-16. 2003
    ..18)F-Desmethoxyfallypride ((18)F-DMFP) is a benzamide tracer with the advantage of an (18)F label. We optimized the synthesis and evaluated (18)F-DMFP in PET studies on healthy human volunteers...
  54. doi request reprint P-glycoprotein influence on the brain uptake of a 5-HT(2A) ligand: [(18)F]MH.MZ
    Ulrich Schmitt
    Institute of Nuclear Chemistry, Johannes Gutenberg University Mainz, Mainz, Germany
    Neuropsychobiology 63:183-90. 2011
    ..The aim of this study was to determine whether transport by P-gp influences the distribution ratio of [(18)F]MH.MZ in the frontal cortex...
  55. doi request reprint Therapeutic plasma concentrations of antidepressants and antipsychotics: lessons from PET imaging
    G Grunder
    Department of Psychiatry, Psychotherapy, and Psychosomatics, Medical Faculty, RWTH Aachen University, Germany
    Pharmacopsychiatry 44:236-48. 2011
    ..Associations between brain target occupancy, plasma concentrations, and clinical effects and adverse reactions will be discussed for the most commonly used antidepressant and antipsychotic drugs...
  56. doi request reprint Spatial learning and expression patterns of PP1 mRNA in mouse hippocampus
    S Haege
    Department of Psychiatry and Psychotherapy, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany
    Neuropsychobiology 61:188-96. 2010
    ....
  57. ncbi request reprint Effects of subchronic paroxetine administration on night-time endocrinological profiles in healthy male volunteers
    R Schlosser
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Str 8, D 55131, Mainz, Germany
    Psychoneuroendocrinology 25:377-88. 2000
    ....
  58. ncbi request reprint Region specific distribution of levomepromazine in the human brain
    J Kornhuber
    Department of Psychiatry, University of Erlangen, Germany
    J Neural Transm 113:387-97. 2006
    ..The aim of this study was to examine concentrations of levomepromazine and its metabolite desmethyl-levomepromazine in different regions of human brain and in relationship to drug-free time...
  59. ncbi request reprint Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates
    Amal Abou El Ela
    Institute of Pharmacy, Biopharmaceutics and Pharmaceutical Technology, University of Mainz, Germany
    J Pharm Pharmacol 56:967-75. 2004
    ..The findings are explained on the basis of the limited contribution of P-gp-mediated transport to the elimination of fluphenazine and to a direct effect with respect to its distribution into the brain...
  60. ncbi request reprint Sex differences in allelic frequencies of the 5-HT2C Cys23Ser polymorphism in psychiatric patients and healthy volunteers: findings from an association study
    C Fehr
    Department of Psychiatry, University of Mainz, Germany
    Psychiatr Genet 10:59-65. 2000
    ..0178). The potential mechanisms of the observed gender difference in allele frequencies, including transmission ratio distortion, are discussed...
  61. ncbi request reprint Day- and night-time contents of monoamines and their metabolites in the medial preoptic area of the rat hypothalamus
    S Reuss
    Department of Anatomy, Johannes Gutenberg University, Mainz, Germany
    Neurosci Lett 266:29-32. 1999
    ..Our results of sex-specific and day time-dependent variations in dopamine and norepinephrine concentrations indicate that the two monoamines are candidate neurotransmitters that may transmit diurnal information to the mPOA...
  62. ncbi request reprint Tiagabine, a gamma-amino-butyric acid transporter inhibitor impairs spatial learning of rats in the Morris water-maze
    Ulrich Schmitt
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Str 8, Germany
    Behav Brain Res 133:391-4. 2002
    ..Retrieval was impaired in rats treated only at the probe trial with tiagabine. These results further elucidate the role of GABA in learning and memory...
  63. ncbi request reprint [Important to atypical antipsychotics: pharmacokinetics, interaction potential and therapeutic drug monitoring]
    Sebastian Hartter
    I Gutenberg Universität Mainz, Psychiatrische Klinik und Poliklinik, Untere Zahlbacher Str 8, 55131 Mainz
    Pharm Unserer Zeit 31:546-57. 2002
  64. ncbi request reprint Automated analysis of quetiapine and other antipsychotic drugs in human blood by high performance-liquid chromatography with column-switching and spectrophotometric detection
    Julia Sachse
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Str 8, D 55131 Mainz, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 830:342-8. 2006
    ..The method was thus suitable for routine therapeutic drug monitoring and may be extended to other drugs...
  65. doi request reprint Pharmacodynamic consequences of P-glycoprotein-dependent pharmacokinetics of risperidone and haloperidol in mice
    Katrin M Kirschbaum
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Strasse 8, Mainz, Germany
    Behav Brain Res 188:298-303. 2008
    ..P-gp-dependent brain distribution kinetics and behavioral effects of risperidone give evidence that the expression of P-gp has an impact on psychotropic drug actions when treating patients with drugs that are substrates of P-gp...
  66. ncbi request reprint Population pharmacokinetic analysis of mirtazapine
    Katja Grasmäder
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53121 Bonn, Germany
    Eur J Clin Pharmacol 60:473-80. 2004
    ..While controlled clinical studies have evaluated the effect of individual covariates on the pharmacokinetics of mirtazapine, our analysis aims to identify covariates within a naturalistic clinical setting...
  67. doi request reprint Pharmacodynamic effects of aripiprazole and ziprasidone with respect to p-glycoprotein substrate properties
    D Holthoewer
    Department of Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
    Pharmacopsychiatry 46:175-80. 2013
    ..Here we tested the pharmacodynamic consequences of these properties in a P-gp deficient mouse model by studying the effects of aripiprazole and of ziprasidone on motor coordination...
  68. ncbi request reprint Behavioral analysis indicates benzodiazepine-tolerance mediated by the benzodiazepine binding-site at the GABA(A)-receptor
    U Schmitt
    Department of Psychiatry, University of Mainz, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 25:1145-60. 2001
    ..In diazepam tolerant animals SKF-89976A produced anxiolytic-like behaviors 4. We conclude that the BZ- and not the GABA-binding site at the GABA(A)-receptor is involved in the development of BZ-tolerance...
  69. ncbi request reprint Fluvoxamine augmentation of olanzapine in chronic schizophrenia: pharmacokinetic interactions and clinical effects
    Christoph Hiemke
    Department of Psychiatry, University of Mainz, Germany
    J Clin Psychopharmacol 22:502-6. 2002
    ....
  70. ncbi request reprint Anxiolytic-like effects of acute and chronic GABA transporter inhibition in rats
    U Schmitt
    Department of Psychiatry, University of Mainz, Mainz, Federal Republic of Germany
    J Neural Transm 109:871-80. 2002
    ..It is concluded that anxiolytic effects of acute GABA-uptake inhibition by tiagabine persist under chronic treatment and are sensitive to concomitant use of benzodiazepine receptor ligands...
  71. ncbi request reprint The HTR1B 861G>C receptor polymorphism among patients suffering from alcoholism, major depression, anxiety disorders and narcolepsy
    C Fehr
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Str 8, D 55101, Mainz, Germany
    Psychiatry Res 97:1-10. 2000
    ....
  72. ncbi request reprint Rotarod impairment: catalepsy-like screening test for antipsychotic side effects
    Katrin M Kirschbaum
    Department of Psychiatry and Psychotherapeutics, University of Mainz, Mainz, Germany
    Int J Neurosci 119:1509-22. 2009
    ..Catalepsy test provided more specificity whereas the rotarod test provided higher degree of sensitivity to motor impairment including catalepsy...
  73. ncbi request reprint Automated determination of amisulpride by liquid chromatography with column switching and spectrophotometric detection
    Julia Sachse
    Department of Psychiatry, University of Mainz, Untere Zahlbacher Str 8, D 55131, Mainz, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 784:405-10. 2003
    ..1%. The performance of daily calibration standards revealed an imprecision always below 15% and maximum inaccuracy of 7.7%. The method can be applied to therapeutic drug monitoring as well as pharmacokinetic studies of amisulpride...
  74. ncbi request reprint Therapeutic drug monitoring of the antidepressant mirtazapine and its N-demethylated metabolite in human serum
    Mohamed Shams
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Ther Drug Monit 26:78-84. 2004
    ..05) lower N-desmethylmirtazapine/mirtazapine ratios were found under concomitant medications of the antidepressant sertraline and the antipsychotic amisulpride...
  75. ncbi request reprint Measurement of duloxetine in blood using high-performance liquid chromatography with spectrophotometric detection and column switching
    Christine Waldschmitt
    Department of Psychiatry, University of Mainz, Mainz, Germany
    Ther Drug Monit 29:767-72. 2007
    ..HPLC with column switching and ultraviolet detection as described here is suitable for pharmacokinetic studies and therapeutic drug monitoring of duloxetine...
  76. pmc A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model
    Rolf Postina
    Institute of Biochemistry, University of Mainz, Mainz, Germany
    J Clin Invest 113:1456-64. 2004
    ....
  77. ncbi request reprint Effects of fluoxetine on behavioral deficits evoked by chronic social stress in rats
    Rafal Rygula
    Clinical Neurobiology Laboratory, German Primate Center, Gottingen, Germany
    Behav Brain Res 174:188-92. 2006
    ..The stress-induced effects on locomotor activity and rearing behavior were counteracted by fluoxetine treatment...
  78. ncbi request reprint New dopamine D2 receptor polymorphisms in rats and association with apomorphine-induced stereotypies
    Sabine Germeyer
    Department of Psychiatry of the University of Mainz, Untere Zahlbacher Strasse 8, D 55131 Mainz, Germany
    Brain Res 926:1-9. 2002
    ..These findings indicate that in Wistar rats at least part of an individual apomorphine stimulated behavioural phenotype might be due to an individual dopamine receptor D2 genotype...
  79. ncbi request reprint Citalopram counteracts depressive-like symptoms evoked by chronic social stress in rats
    Rafal Rygula
    Department of Psychiatry and Psychotherapy, University of Gottingen, Germany
    Behav Pharmacol 17:19-29. 2006
    ..These observations provide evidence for the predictive validity of the chronic social stress paradigm as a model of depressive symptoms in rats...
  80. ncbi request reprint Appropriateness of plasma level determinations for lithium and valproate in routine care of psychiatric inpatients with affective disorders
    Klaus Mann
    J Clin Psychopharmacol 26:671-3. 2006
  81. ncbi request reprint Assessment of storage and transport stability of new antidepressant and antipsychotic drugs for a nationwide TDM service
    Sandra Heller
    Ther Drug Monit 26:459-61. 2004
  82. ncbi request reprint Therapeutic drug monitoring-based clozapine dosing recommendations
    Gerald Zernig
    Ther Drug Monit 29:130-1. 2007
  83. ncbi request reprint Elevated quetiapine serum concentrations in a patient treated concomitantly with doxepin, lorazepam, and pantoprazole
    Sebastian Hartter
    J Clin Psychopharmacol 24:568-71. 2004
  84. doi request reprint Pharmacological validation of a chronic social stress model of depression in rats: effects of reboxetine, haloperidol and diazepam
    Rafal Rygula
    Department of Psychiatry and Psychotherapy, University of Gottingen, Gottingen, Germany
    Behav Pharmacol 19:183-96. 2008
    ....
  85. doi request reprint Brain and plasma pharmacokinetics of aripiprazole in patients with schizophrenia: an [18F]fallypride PET study
    Gerhard Grunder
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany
    Am J Psychiatry 165:988-95. 2008
    ....
  86. pmc The AGNP-TDM Expert Group Consensus Guidelines: focus on therapeutic monitoring of antidepressants
    Pierre Baumann
    Department of Psychiatry, University of Lausanne, Prilly Lausanne, Switzerland
    Dialogues Clin Neurosci 7:231-47. 2005
    ..These consensus guidelines should be helpful for optimizing TDM of antidepressants...
  87. ncbi request reprint What the clinician still has to be reminded of
    Gerald Zernig
    Ther Drug Monit 26:582. 2004
  88. ncbi request reprint Clinical relevance of TDM of SSRIs
    Markus J Schwarz
    Ther Drug Monit 28:716-7; author reply 717. 2006
  89. ncbi request reprint Effect of chronic citalopram on serotonin-related and stress-regulated genes in the dorsal raphe nucleus of the rat
    Nashat Abumaria
    Laboratory of Clinical Neurobiology, German Primate Center, Kellnerweg 4, 37077 Gottingen, Germany
    Eur Neuropsychopharmacol 17:417-29. 2007
    ..These findings demonstrate that in the dorsal raphe nucleus of chronically stressed rats, citalopram normalizes TPH expression and blocks stress effects on distinct genes related to neurotransmitter release and neuroplasticity...
  90. ncbi request reprint Schizophrenic patients who smoke have a faster finger tapping rate than non-smokers
    Henry Silver
    Flugelman Mazra Psychiatric Hospital, Doar Na Ashrat, Israel
    Eur Neuropsychopharmacol 12:141-4. 2002
    ..Nicotine can improve central processing in medicated schizophrenia patients and this may constitute part of the incentive for smoking...
  91. ncbi request reprint The chronic psychosocial stress paradigm in male tree shrews: evaluation of a novel animal model for depressive disorders
    Marja Van Kampen
    Division of Neurobiology, German Primate Center, Kellnerweg 4, 37077 Gottingen, Germany
    Stress 5:37-46. 2002
    ....
  92. ncbi request reprint Chronic social stress inhibits cell proliferation in the adult medial prefrontal cortex: hemispheric asymmetry and reversal by fluoxetine treatment
    Boldizsar Czeh
    Clinical Neurobiology Laboratory, German Primate Center, Gottingen, Germany
    Neuropsychopharmacology 32:1490-503. 2007
    ..These pronounced changes in gliogenesis after chronic stress exposure may relate to the abnormalities of glial cell numbers reported in the frontolimbic areas of depressed patients...
  93. ncbi request reprint The TPH intron 7 A218C polymorphism and TCI dimension scores in alcohol-dependent patients: hints to nonspecific psychopathology
    Ion Anghelescu
    Department of Psychiatry and Psychotherapy, Charite, University Medicine Berlin, Campus Benjamin Franklin, Eschenallee 3, 14050 Berlin, Germany
    Addict Behav 30:1135-43. 2005
    ....