R Heun

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. ncbi request reprint Depression in Alzheimer's disease: is there a temporal relationship between the onset of depression and the onset of dementia?
    Reinhard Heun
    Department of Psychiatry of the University of Bonn, Sigmund Freud Str 25, 53105, Bonn, Germany
    Eur Psychiatry 17:254-8. 2002
  2. ncbi request reprint Differences of cerebral activation between superior and inferior learners during motor sequence encoding and retrieval
    Reinhard Heun
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Psychiatry Res 132:19-32. 2004
  3. ncbi request reprint Response-related fMRI analysis during encoding and retrieval revealed differences in cerebral activation by retrieval success
    R Heun
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, Venusberg, D 53105, Bonn, Germany
    Psychiatry Res 99:137-50. 2000
  4. ncbi request reprint Interindividual variation of cerebral activation during encoding and retrieval of words
    R Heun
    Department of Psychiatry, University of Bonn, Venusberg, D 53105 Bonn, Germany
    Eur Psychiatry 15:470-9. 2000
  5. ncbi request reprint A family study of Alzheimer disease and early- and late-onset depression in elderly patients
    R Heun
    Department of Psychiatry, University of Bonn, Venusberg, D 53105 Bonn, Germany
    Arch Gen Psychiatry 58:190-6. 2001
  6. ncbi request reprint Distinction of early- and late-onset depression in the elderly by their lifetime symptomatology
    R Heun
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53127 Bonn, Germany
    Int J Geriatr Psychiatry 15:1138-42. 2000
  7. ncbi request reprint Contribution of apolipoprotein E and cathepsin D genotypes to the familial aggregation of Alzheimer's disease
    Reinhard Heun
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Dement Geriatr Cogn Disord 18:151-8. 2004
  8. ncbi request reprint No evidence for a genetic relationship between Alzheimer's disease and longevity
    Reinhard Heun
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Dement Geriatr Cogn Disord 18:1-5. 2004
  9. ncbi request reprint Subjective memory complaints of family members of patients with Alzheimer's disease and depression
    Reinhard Heun
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Dement Geriatr Cogn Disord 16:78-83. 2003
  10. ncbi request reprint Lifetime symptoms of depression in Alzheimer's disease
    Reinhard Heun
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur Psychiatry 18:63-9. 2003

Collaborators

Detail Information

Publications112 found, 100 shown here

  1. ncbi request reprint Depression in Alzheimer's disease: is there a temporal relationship between the onset of depression and the onset of dementia?
    Reinhard Heun
    Department of Psychiatry of the University of Bonn, Sigmund Freud Str 25, 53105, Bonn, Germany
    Eur Psychiatry 17:254-8. 2002
    ..However, the increased incidence of MD within 5 years before and after the onset of dementia may indicate that a common neurobiological process causes cognitive decline and depression in a subsample of AD patients...
  2. ncbi request reprint Differences of cerebral activation between superior and inferior learners during motor sequence encoding and retrieval
    Reinhard Heun
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Psychiatry Res 132:19-32. 2004
    ..e. success and effort. Further intervention studies are needed to assess whether these interindividual differences are the cause or the consequence of differences in memory performance...
  3. ncbi request reprint Response-related fMRI analysis during encoding and retrieval revealed differences in cerebral activation by retrieval success
    R Heun
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, Venusberg, D 53105, Bonn, Germany
    Psychiatry Res 99:137-50. 2000
    ..Increased activation during false alarms might reflect a source-monitoring deficit or an increased subjective familiarity with distractors that have been most intensively processed in extrastriate visual cortex...
  4. ncbi request reprint Interindividual variation of cerebral activation during encoding and retrieval of words
    R Heun
    Department of Psychiatry, University of Bonn, Venusberg, D 53105 Bonn, Germany
    Eur Psychiatry 15:470-9. 2000
    ..The investigation of these interindividual variations will be an exciting scientific challenge in the near future...
  5. ncbi request reprint A family study of Alzheimer disease and early- and late-onset depression in elderly patients
    R Heun
    Department of Psychiatry, University of Bonn, Venusberg, D 53105 Bonn, Germany
    Arch Gen Psychiatry 58:190-6. 2001
    ..The substantial symptomatic overlap between depression and dementia in old age may be explained by common genetic vulnerability factors...
  6. ncbi request reprint Distinction of early- and late-onset depression in the elderly by their lifetime symptomatology
    R Heun
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53127 Bonn, Germany
    Int J Geriatr Psychiatry 15:1138-42. 2000
    ..To validate the phenomenological distinction, the affective symptoms of elderly subjects with EOD and LOD were compared...
  7. ncbi request reprint Contribution of apolipoprotein E and cathepsin D genotypes to the familial aggregation of Alzheimer's disease
    Reinhard Heun
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Dement Geriatr Cogn Disord 18:151-8. 2004
    ..The familial aggregation of late-onset Alzheimer's disease (AD) might be caused by the clustering of genetic risk factors in families. This study investigates the influence of variants of candidate genes on the familial aggregation of AD...
  8. ncbi request reprint No evidence for a genetic relationship between Alzheimer's disease and longevity
    Reinhard Heun
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Dement Geriatr Cogn Disord 18:1-5. 2004
    ..AD and life expectancy are both influenced by genetic factors. Consequently, a possible genetic relationship between AD and longevity was investigated using family study data...
  9. ncbi request reprint Subjective memory complaints of family members of patients with Alzheimer's disease and depression
    Reinhard Heun
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Dement Geriatr Cogn Disord 16:78-83. 2003
    ..To investigate the relevance of the above-mentioned hypotheses, the prevalence rates of subjective memory complaints of first-degree relatives and spouses of patients with AD, of patients with MD and of control subjects were compared...
  10. ncbi request reprint Lifetime symptoms of depression in Alzheimer's disease
    Reinhard Heun
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur Psychiatry 18:63-9. 2003
    ..The symptomatology of depression in dementia may differ from depression alone. Consequently, the reports on lifetime depressive symptoms were compared in AD patients and age-matched non-demented participants...
  11. ncbi request reprint Lifetime depressive and somatic symptoms as preclinical markers of late-onset depression
    Sandra Hein
    Department of Psychiatry, University of Bonn, Venusberg, 53105 Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 253:16-21. 2003
    ..Consequently, we examined lifetime depressive and somatic symptoms with respect to later development of late-onset depression...
  12. ncbi request reprint Psychiatric disorders in relatives of subjects with Alzheimer's disease. No evidence for common genetic risk factors
    Reinhard Heun
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 252:93-7. 2002
    ..Consequently, family study data were reinvestigated to assess, if there are indications for an overlap of genetic risk factors of AD and other psychiatric disorders...
  13. ncbi request reprint Response-related fMRI of veridical and false recognition of words
    Reinhard Heun
    Department of Psychiatry, University of Bonn, Sigmund Freud Street 25, Venusberg, 53105 Bonn, Germany
    Eur Psychiatry 19:42-52. 2004
    ..The present study intends to replicate and extend this observation by investigating common and differential activation by veridical and false recognition...
  14. ncbi request reprint Differential validity of informant-based diagnoses of dementia and depression in index subjects and in their first-degree relatives
    R Heun
    Department of Psychiatry, University of Bonn, Germany
    Soc Psychiatry Psychiatr Epidemiol 33:510-3. 1998
    ..Observations in selected samples, i.e. subjects treated, hospitalised and/or autopsied, cannot be generalised to first-degree relatives in family studies...
  15. ncbi request reprint Functional MRI of cerebral activation during encoding and retrieval of words
    R Heun
    Department of Psychiatry, University of Bonn, Germany
    Hum Brain Mapp 8:157-69. 1999
    ..The comparison of event-related activation occurring within one trial block instead of among several trial blocks may significantly improve the performance of memory studies...
  16. ncbi request reprint [The 4-week prevalence of somatoform disorders and associated psychosocial impairment]
    D Schoepf
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Universitatsklinikum Bonn
    Nervenarzt 74:245-51. 2003
    ..3 days of absence in work during the last month in female patients. The coexistence of SFS with other psychiatric disorders resulted in a greater extent of psychosocial impairment...
  17. ncbi request reprint Genetic polymorphism of cathepsin D is strongly associated with the risk for developing sporadic Alzheimer's disease
    A Papassotiropoulos
    Department of Psychiatry, University of Bonn, Germany
    Neurosci Lett 262:171-4. 1999
    ..The odds ratio for subjects with the apolipoprotein E epsilon 4 and the cathepsin D*T allele was 5.9. Our data suggest that the cathepsin D genotype is strongly associated with the risk for Alzheimer's disease...
  18. ncbi request reprint Polymorphisms in glutathione S-transferase omega-1 and AD, vascular dementia, and stroke
    H Kolsch
    Department of Psychiatry, University of Bonn, Germany
    Neurology 63:2255-60. 2004
    ..Polymorphisms in GSTO1 might influence the function of the protein and thus the risk of AD, VaD, and stroke...
  19. ncbi request reprint Association between an interleukin-6 promoter and 3' flanking region haplotype and reduced Alzheimer's disease risk in a German population
    M Bagli
    Department of Psychiatry and Psychotherapy, Rheinische Friedrich Wilhelms Universitat, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Neurosci Lett 283:109-12. 2000
    ..However, haplotype analysis showed a strong linkage disequilibrium between IL-6vntr and IL-6prom and demonstrated an interaction between IL-6vntr and IL-6prom which modifies AD risk...
  20. ncbi request reprint Common genetic variants of homocysteine metabolism in ischemic stroke: a case-control study
    M Linnebank
    Department of Neurology, University Hospital Bonn, Bonn, Germany
    Eur J Neurol 12:614-8. 2005
    ..677 C > T could be a minor factor of vulnerability especially in young patients (TT genotype), which might be helpful for the clinical work-up of stroke cases and for preventive dietary strategies...
  21. doi request reprint Association of CETP polymorphisms with the risk of vascular dementia and white matter lesions
    H Qureischie
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    J Neural Transm 116:467-72. 2009
    ..009). Our results suggest that CETP gene polymorphisms might influence WML load and the risk of VD, the latter in non-carriers of the APOE4 allele...
  22. ncbi request reprint Gene variations in GSTM3 are a risk factor for Alzheimer's disease
    G S Hong
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Neurobiol Aging 30:691-6. 2009
    ..95). The population attributable risk of this haplotype in APOE4-allele non-carriers was 32.2%. Our results suggest that there is a group of AD patients in which variations in metabolism of oxidative stress play an important role...
  23. ncbi request reprint Polymorphism in the peroxisome proliferator-activated receptor alpha gene influences the risk for Alzheimer's disease
    S Brune
    Department of Psychiatry, University of Bonn, Germany
    J Neural Transm 110:1041-50. 2003
    ..Cerebrospinal fluid amyloid-beta levels were influenced by PPAR-alpha L162V genotype. These results suggest, that PPAR-alpha polymorphism may be a risk factor for AD...
  24. ncbi request reprint Early-onset and late-onset depression are independent of the genetic polymorphism of apolipoprotein E
    A Papassotiropoulos
    Department of Psychiatry, University of Bonn, Germany
    Dement Geriatr Cogn Disord 10:258-61. 1999
    ..Our data do not disconfirm the hypothesis of depression sharing some common pathophysiologic features with AD, however, it seems very unlikely that the APOE genotype will elucidate the assumed common mechanisms...
  25. ncbi request reprint Proton MR spectroscopy detects a relative decrease of N-acetylaspartate in the medial temporal lobe of patients with AD
    F Jessen
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Neurology 55:684-8. 2000
    ..The reduction of N-acetylaspartate (NAA) detected by proton MR spectroscopy (1H-MRS) represents a robust but unspecific marker for neuronal loss or dysfunction...
  26. ncbi request reprint The validity of psychometric instruments for detection of dementia in the elderly general population
    R Heun
    Department of Psychiatry, University of Bonn, Germany
    Int J Geriatr Psychiatry 13:368-80. 1998
    ..To compare the validity of different instruments for screening and diagnosis of dementia and to provide threshold scores for these purposes, ie screening focusing on a high sensitivity and diagnosis focusing on a high specificity...
  27. ncbi request reprint Alpha-1-antichymotrypsin gene polymorphism and risk for sporadic Alzheimer's disease in a German population
    S G Schwab
    Department of Psychiatry, University of Bonn, Germany
    Dement Geriatr Cogn Disord 10:469-72. 1999
    ..When we analyzed the polymorphism in APOE epsilon4 carriers, no overrepresentation in our AD group could be shown for the ACT*AA genotype carriers. Copyrightz1999S.KargerAG,Basel..
  28. ncbi request reprint Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's disease
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Mol Psychiatry 7:899-902. 2002
    ..Our results indicate that the CYP46 gene locus may predispose to AD by increasing the 24S-hydroxycholesterol/cholesterol ratio in the brain...
  29. ncbi request reprint Seasonal distribution of births in patients with Alzheimer's disease and elderly depressive patients
    U Ptok
    Department of Psychiatry, University of Bonn, Sigmund Freud St 25 53105, Bonn, Germany
    Eur Psychiatry 16:157-61. 2001
    ..We concluded that in our sample a seasonal distribution of births was not found to increase the risk for AD or geriatric depression...
  30. ncbi request reprint Influence of peroxisome proliferator-activated receptor gamma gene polymorphism on 24S-hydroxycholesterol levels in Alzheimer's patients
    S Sauder
    Department of Psychiatry, University of Bonn, Germany
    J Neural Transm 112:1381-9. 2005
    ..PPARgamma polymorphism did not influence the risk of AD. These results might point to an influence of PPARgamma Pro12Ala polymorphism on the elimination of 24S-hydroxycholesterol...
  31. ncbi request reprint The insulin gene VNTR polymorphism in Alzheimer's disease: results of a pilot study
    M Majores
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Federal Republic of Germany
    J Neural Transm 109:1029-34. 2002
    ..002). Our preliminary results suggest, that genetically determined alterations of the INS/IGF-2 metabolism might modify the course of AD. Further studies are warranted to confirm these data in larger study samples...
  32. ncbi request reprint No association between an intronic polymorphism in the presenilin-1 gene and Alzheimer disease in a German population
    M Bagli
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    J Neurol Sci 167:34-6. 1999
    ..Our data do not support an association between the intronic polymorphism of the PS-1 gene and AD and there was no interaction between the PS-1 genotype and apolipoprotein E epsilon4 allele...
  33. ncbi request reprint Allelic association between the D10S1423 marker and Alzheimer's disease in a German population
    M Majores
    Department of Psychiatry, University of Bonn, Germany
    Neurosci Lett 289:224-6. 2000
    ..033). In conclusion, our results support that the D10S1423 marker is associated with an increased AD risk and provides further evidence for an AD susceptibility locus on chromosome 10...
  34. ncbi request reprint Polymorphism in neuropeptide Y influences CSF cholesterol levels but is no major risk factor of Alzheimer's disease
    H Kolsch
    Department of Psychiatry, University of Bonn, Bonn, Germany
    J Neural Transm 113:231-8. 2006
    ..Both NPY polymorphisms did not influence the risk of AD. Our data support the observation, that NPY polymorphisms might influence cholesterol metabolism, but might not act as major risk factor in AD...
  35. ncbi request reprint ACE I/D polymorphism is a risk factor of Alzheimer's disease but not of vascular dementia
    H Kolsch
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Neurosci Lett 377:37-9. 2005
    ..Cell-specific effects of ACE polymorphism are suggested, additional studies on neuronal cells might help to understand the role of this polymorphism in AD...
  36. ncbi request reprint Identical distribution of the alpha 2-macroglobulin pentanucleotide deletion in subjects with Alzheimer disease and controls in a German population
    M Bagli
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Am J Med Genet 96:775-7. 2000
    ..Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:775-777, 2000...
  37. ncbi request reprint Decrease of N-acetylaspartate in the MTL correlates with cognitive decline of AD patients
    F Jessen
    Department of Psychiatry, University of Bonn, Germany
    Neurology 57:930-2. 2001
    ..The reduction of NAA/Cr in the MTL represents a correlate of cognitive deterioration in AD, whereas it is of limited use to detect subtle changes over time in clinically stable patients...
  38. ncbi request reprint Influence of lysosomal acid lipase polymorphisms on chromosome 10 on the risk of Alzheimer's disease and cholesterol metabolism
    K T von Trotha
    Department of Psychiatry, Sigmund Freud Street 25, University of Bonn, 53105 Bonn, Germany
    Neurosci Lett 402:262-6. 2006
    ..Even though the biological function and gene location of LIPA on chromosome 10 suggest that LIPA might be a candidate for an AD risk gene, our results revealed that polymorphisms in LIPA did not influence the risk of AD in our study...
  39. ncbi request reprint Physical disorders and causes of death in relatives of Alzheimer's disease patients
    M Kockler
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Int J Geriatr Psychiatry 17:335-42. 2002
    ..g. Down's syndrome or Parkinson's disease. In the present study the risk of physical disorders in relatives of AD patients, of depressed patients and of control subjects were compared...
  40. ncbi request reprint Inter-rater reliability of family history information on psychiatric disorders in relatives
    U Ptok
    Department of Psychiatry, University of Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 251:279-83. 2001
    ..41-1.00) and any psychiatric disorder (kappa=0.79, 95% CI=0.66-0.91). We concluded that the family history interview is a useful family study instrument that can be applied reliably by different raters for frequent psychiatric disorders...
  41. ncbi request reprint CYP2D6 polymorphism and tardive dyskinesia in schizophrenic patients
    P L Lohmann
    Department of Psychiatry, University of Bonn, Germany
    Pharmacopsychiatry 36:73-8. 2003
    ..In conclusion, our results provide no evidence for the contribution of CYP2D6 genotype to the development of TD in schizophrenic patients receiving long-term antipsychotic medication...
  42. ncbi request reprint Amygdala-hippocampal atrophy and memory performance in dementia of Alzheimer type
    R Heun
    Department of Psychiatry, University of Mainz, Germany
    Dement Geriatr Cogn Disord 8:329-36. 1997
    ..Consequently, DAT seems to affect the amygdala-hippocampal complex and their related function (i.e. memory) more than other cerebral structures, but cerebral degeneration in DAT is not restricted to these structures...
  43. ncbi request reprint Identification of items which predict later development of depression in primary health care
    K Barkow
    Department of Psychiatry, University of Bonn
    Eur Arch Psychiatry Clin Neurosci 251:II21-6. 2001
    ..The present results might be helpful for future development of prediction scales...
  44. ncbi request reprint Sensory gating deficit expressed by a disturbed suppression of the P50 event-related potential in patients with Alzheimer's disease
    F Jessen
    Department of Psychiatry, University of Bonn, Sigmind Freud Str 25, 53105 Bonn, Germany
    Am J Psychiatry 158:1319-21. 2001
    ..In this study, the authors tested whether sensory gating is disturbed in patients with Alzheimer's disease...
  45. ncbi request reprint Activation of human language processing brain regions after the presentation of random letter strings demonstrated with event-related functional magnetic resonance imaging
    F Jessen
    Department of Psychiatry, University of Bonn, Germany
    Neurosci Lett 270:13-6. 1999
    ..Real words contrasted with random letter strings activated the left angular gyrus, bilateral precuneus and the left posterior cingulate gyrus, which may reflect the access of higher semantic associations...
  46. ncbi request reprint The impact of gender and age at onset on the familial aggregation of schizophrenia
    W Maier
    Department of Psychiatry, University of Mainz, Germany
    Eur Arch Psychiatry Clin Neurosci 242:279-85. 1993
    ..Affective disorders occurred in families independently of the probands' gender. Aetiological heterogeneity or ascertainment bias may account for the modifying effect of proband's gender in schizophrenia...
  47. ncbi request reprint Risk factors for new depressive episodes in primary health care: an international prospective 12-month follow-up study
    K Barkow
    Department of Psychiatry, University of Bonn, Germany
    Psychol Med 32:595-607. 2002
    ..Most samples had originated from highly developed industrial countries. This is the first study that prospectively investigates the risk factors of depressive episodes in an international primary care sample...
  48. ncbi request reprint The factor structure in the cognitive battery of the structured interview for the diagnosis of dementia of the Alzheimer type, multi-infarct dementia, and dementias of other aetiology
    M Kockler
    Department of Psychiatry, University of Bonn, Germany
    Int Psychogeriatr 13:311-23. 2001
    ..Syndrome scores should reflect these dimensions. Consequently, we propose to consider the empirically found factor structure in a new version of the SIDAM...
  49. ncbi request reprint The concreteness effect: evidence for dual coding and context availability
    F Jessen
    Department of Psychiatry, University of Bonn, Germany
    Brain Lang 74:103-12. 2000
    ....
  50. ncbi request reprint Advanced parental age: a risk factor for Alzheimer's disease or depression in the elderly?
    U Ptok
    Department of Psychiatry, University of Bonn, Germany
    Int Psychogeriatr 12:445-51. 2000
    ..In the present investigation, a sample of gerontopsychiatric patients was examined for a possible parental age effect...
  51. ncbi request reprint Interinformant reliability of family history information on psychiatric disorders in relatives
    R Heun
    Department of Psychiatry, University of Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 248:104-9. 1998
    ..It seems more important for the diagnosis of depression than for a diagnosis of dementia to get information from multiple informants...
  52. ncbi request reprint Altered levels of plasma 24S- and 27-hydroxycholesterol in demented patients
    H Kolsch
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Neurosci Lett 368:303-8. 2004
    ..Our results support the observation, that cholesterol metabolism is altered in dementing disorders, indicated by different plasma concentrations of brain specific and peripherally produced oxysterols...
  53. ncbi request reprint Psychometric analysis of the selective reminding procedure in a sample from the general elderly population
    M Burkart
    Department of Psychiatry, University of Mainz, Germany
    Dement Geriatr Cogn Disord 11:74-80. 2000
    ..Thus, the SRP may neither be recommended for assessment of different subfunctions of memory nor for dementia screening...
  54. ncbi request reprint Amplitude reduction of the mismatch negativity in first-degree relatives of patients with schizophrenia
    F Jessen
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25 53105 Bonn, Germany
    Neurosci Lett 309:185-8. 2001
    ..These results provide first evidence for disturbed sensory memory in relatives of patients with schizophrenia...
  55. pmc The methionine synthase polymorphism D919G alters susceptibility to primary central nervous system lymphoma
    M Linnebank
    Department of Neurology, University Hospital of Bonn, Sigmund Freud Str 25, Bonn D 53125, Germany
    Br J Cancer 90:1969-71. 2004
    ..26, CI(95%): 0.09-0.74; P=0.005), suggesting a protective function of the G allele. These data stimulate further epidemiological and functional studies focusing on the role of homocysteine and folate metabolism in lymphoma tumorigenesis...
  56. ncbi request reprint 24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia
    A Papassotiropoulos
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    J Psychiatr Res 36:27-32. 2002
    ..We believe that the CSF concentration of 24S-hydroxycholesterol is altered in AD-related neurodegeneration and thus, CSF 24S-hydroxycholesterol may be a marker for monitoring the onset and progression of the disease...
  57. ncbi request reprint A genetic variation of cathepsin D is a major risk factor for Alzheimer's disease
    A Papassotiropoulos
    Department of Psychiatry, University of Bonn, Germany
    Ann Neurol 47:399-403. 2000
    ..0 compared with subjects with neither of these two alleles. Our data confirm the results of a recently performed pilot study in an independent sample and suggest that the catD genotype is strongly associated with the risk for AD...
  58. ncbi request reprint Gender differences of depressive symptoms in depressed and nondepressed elderly persons
    M Kockler
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Int J Geriatr Psychiatry 17:65-72. 2002
    ..However, few studies investigated gender differences of depressive symptoms in the elderly. These gender differences in the elderly will be investigated in the present study...
  59. ncbi request reprint CSF tau protein phosphorylated at threonine 231 correlates with cognitive decline in MCI subjects
    K Buerger
    Dementia Research Section and Memory Clinic, Alzheimer Memorial Center, Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Neurology 59:627-9. 2002
    ..Independently, old age and APOE-epsilon 4 carrier status were predictive as well. Our data indicate that an increased p-tau(231) level is a potential risk factor for cognitive decline in patients with MCI...
  60. doi request reprint Type-2 diabetes mellitus in schizophrenia: increased prevalence and major risk factor of excess mortality in a naturalistic 7-year follow-up
    D Schoepf
    Department of Psychiatry and Psychotherapy, University of Bonn, 53125 Bonn, Germany
    Eur Psychiatry 27:33-42. 2012
    ....
  61. ncbi request reprint Multicenter assessment of reliability of cranial MRI
    M Ewers
    Department of Psychiatry, Dementia and Neuroimaging Section, Alzheimer Memorial Center D2, Ludwig Maximilian University of Munich, Nussbaumstr 7, 80336 Munich, Germany
    Neurobiol Aging 27:1051-9. 2006
    ..42) showed that the total sample size needed is N=180. In conclusion, despite minimal inclusion criteria, the reliability of MRI across centers was relatively good...
  62. doi request reprint A multicenter (1)H-MRS study of the medial temporal lobe in AD and MCI
    F Jessen
    Department of Psychiatry, University of Bonn, Germany
    Neurology 72:1735-40. 2009
    ..Within the German Competence Network on Dementia, we conducted a (1)H-MRS study in patients with mild dementia and mild cognitive impairment (MCI) at four sites to investigate the multicenter feasibility of (1)H-MRS...
  63. ncbi request reprint Detection of subthreshold depression and subthreshold anxiety in the elderly
    A Papassotiropoulos
    Department of Psychiatry, University of Bonn, Germany
    Int J Geriatr Psychiatry 14:643-50. 1999
    ..To assess the ability of screening instruments to detect subthreshold depression or subthreshold anxiety and to make suggestions for the improvement of instrument performance...
  64. ncbi request reprint Validity of the five-item WHO Well-Being Index (WHO-5) in an elderly population
    M Bonsignore
    Department of Psychiatry, University of Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 251:II27-31. 2001
    ..The second version is a stronger scale and was more specific for the detection of depression. The WHO-5 is an useful instrument for identifying elderly subjects with depression...
  65. ncbi request reprint Encoding and retrieval related cerebral activation in continuous verbal recognition
    F Jessen
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Brain Res Cogn Brain Res 12:199-206. 2001
    ..The results are discussed in relation to current concepts of spatial differentiation of memory function and findings from event-related potentials studies of continuous recognition...
  66. ncbi request reprint The role of 24S-hydroxycholesterol in Alzheimer's disease
    H Kolsch
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53127 Bonn, Germany
    J Nutr Health Aging 7:37-41. 2003
    ..This review will give a brief overview on the relevance of 24S-hydroxycholesterol as a possible risk factor and diagnostic state marker for AD...
  67. ncbi request reprint Fertility and number of children in patients with Alzheimer's disease
    U Ptok
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Arch Womens Ment Health 5:83-6. 2002
    ..The number of children did not seem to affect the risk of Alzheimer's disease, neither in female nor in male subjects. Natural exposure to oestrogen seems to reduce the risk of Alzheimer's disease in women...
  68. ncbi request reprint Screening for depression in the elderly: a study on misclassification by screening instruments and improvement of scale performance
    A Papassotiropoulos
    Department of Psychiatry, University of Bonn, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 23:431-46. 1999
    ..However, both questionnaires yielded a considerable proportion of false positive results. Elevation of the cut-off score may reduce the misclassification rate of the GHQ-12 but not that of the CES-D...
  69. ncbi request reprint Association between a functional polymorphism in the monoamine oxidase A gene promoter and major depressive disorder
    T G Schulze
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Am J Med Genet 96:801-3. 2000
    ..Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:801-803, 2000...
  70. ncbi request reprint No association of serum levels of interleukin-6 and its soluble receptor components with a genetic variation in the 3'flanking region of the interleukin-6 gene in patients with multiple sclerosis
    S Schmidt
    Department of Neurology, University of Bonn, Sigmund Freud Strasse 25, D 53105, Bonn, Germany
    Neurosci Lett 294:139-42. 2000
    ....
  71. ncbi request reprint Possible influence of selection bias on gender differences in the risk of Alzheimer's disease
    M Bonsignore
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Arch Womens Ment Health 5:73-7. 2002
    ..Study methods must be taken into account when interpreting information on gender differences in the risk of AD...
  72. ncbi request reprint Polymorphism in ABCA1 influences CSF 24S-hydroxycholesterol levels but is not a major risk factor of Alzheimer's disease
    Heike Kolsch
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    Int J Mol Med 17:791-4. 2006
    ..Our data support the observation that ABCA1 polymorphisms influence cholesterol metabolism of the brain, but might not act as a major risk factor in AD...
  73. ncbi request reprint A comparative study of the different N-acetylaspartate measures of the medial temporal lobe in Alzheimer's disease
    Frank Jessen
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Dement Geriatr Cogn Disord 20:178-83. 2005
    ..To investigate group differences and correlations and to determine the sensitivity and specificity of different measures of the neuronal marker N-acetylaspartate (NAA) in the medial temporal lobe of Alzheimer's Disease (AD) patients...
  74. doi request reprint Subjective Memory Impairment. A review of its definitions indicates the need for a comprehensive set of standardised and validated criteria
    Khaled Abdulrab
    Medical School, University of Birmingham, Birmingham, UK
    Eur Psychiatry 23:321-30. 2008
    ..Subjective Memory Impairment (SMI) may hold value in the elderly as a predictor of dementia. There is yet to exist any standard definition of SMI for use in research or for clinical practice...
  75. ncbi request reprint APOA1 polymorphism influences risk for early-onset nonfamiliar AD
    Heike Vollbach
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Ann Neurol 58:436-41. 2005
    ..No influence of the +83/84bp polymorphism on the risk for AD was observed. These results suggest that variants of APOA1 might influence the onset and the risk for AD...
  76. ncbi request reprint The effects of gender and CYP46 and apo E polymorphism on 24S-hydroxycholesterol levels in Alzheimer's patients treated with statins
    Gloria Lena Vega
    Department of Clinical Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9052, USA
    Curr Alzheimer Res 1:71-7. 2004
    ..Polymorphisms of CYP46 or apo E do not explain levels of oxysterol or non-HDL cholesterol or the responsiveness to statin treatment in this study...
  77. ncbi request reprint Volume reduction of the entorhinal cortex in subjective memory impairment
    Frank Jessen
    Department of Psychiatry, University of Bonn, Germany
    Neurobiol Aging 27:1751-6. 2006
    ..The mean volume reduction of the hippocampus was 6% (SMI), 16% (MCI) and 19% (AD). Our results mirror the temporal sequence of neurodegeneration in AD and support the concept of SMI as the first clinical manifestation of dementia...
  78. ncbi request reprint The ADH1C stop mutation in multiple system atrophy patients and healthy probands in the United Kingdom and Germany
    Ina Schmitt
    Mov Disord 21:2034. 2006
  79. ncbi request reprint Successful verbal retrieval in elderly subjects is related to concurrent hippocampal and posterior cingulate activation
    Reinhard Heun
    Department of Psychiatry, University of Birmingham, Birmingham, UK
    Dement Geriatr Cogn Disord 22:165-72. 2006
    ..We chose a correlational over the more traditional categorical approach to increase the power of detecting relevant activations...
  80. ncbi request reprint Familial aggregation of depression, but no familial aggregation of individual depressive symptoms
    Reinhard Heun
    The University of Birmingham, Division of Neuroscience, Queen Elizabeth Psychiatric Hospital, Mindelsohn Way, Birmingham B15 2QZ, United Kingdom
    Eur Psychiatry 22:16-21. 2007
    ..Up to now, no study investigated the possibility of a relationship between individual depressive symptoms and the familial aggregation of depression...
  81. ncbi request reprint A functional polymorphism within plasminogen activator urokinase (PLAU) is associated with Alzheimer's disease
    Matthias Riemenschneider
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany
    Hum Mol Genet 15:2446-56. 2006
    ..Further functional investigations are warranted to elucidate the specific role of PLAU, respectively, PLAU variants in the metabolism of Abeta proteins...
  82. ncbi request reprint Association of polymorphism in the transcription factor LBP-1c/CP2/LSF gene with Alzheimer's disease and major depression
    Schamim Schahab
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Dement Geriatr Cogn Disord 22:95-8. 2006
    ..These data suggest the presence of a putative risk gene for major depression at chromosome 12...
  83. pmc Identification of the genetic basis for complex disorders by use of pooling-based genomewide single-nucleotide-polymorphism association studies
    John V Pearson
    Translational Genomics Research Institute, Phoenix, AZ, 85004, USA
    Am J Hum Genet 80:126-39. 2007
    ....
  84. ncbi request reprint Mild cognitive impairment (MCI) and actual retrieval performance affect cerebral activation in the elderly
    Reinhard Heun
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Neurobiol Aging 28:404-13. 2007
    ..Activation differences between response categories might reflect success (hits) and effort (misses). Increased retrieval-related activation may be used as early marker in subjects at risk of Alzheimer's disease...
  85. ncbi request reprint A multicenter reproducibility study of single-voxel 1H-MRS of the medial temporal lobe
    Frank Träber
    Department of Radiology, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Eur Radiol 16:1096-103. 2006
    ..This is the basis for applying (1)H-MRS in large-scale early recognition and treatment studies in MTL affecting disorders...
  86. pmc Hippocampal activation in patients with mild cognitive impairment is necessary for successful memory encoding
    Tilo T Kircher
    Department of Neurology, RWTH Aachen, Pauwelsstr 30, D 52074 Aachen, Germany
    J Neurol Neurosurg Psychiatry 78:812-8. 2007
    ..Episodic memory enables us to consciously recollect personally experienced past events. Memory performance is reduced in patients with mild cognitive impairment (MCI), an at-risk condition for Alzheimer's disease (AD)...
  87. ncbi request reprint PPARD haplotype influences cholesterol metabolism but is no risk factor of Alzheimer's disease
    Julia Holzapfel
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Neurosci Lett 408:57-61. 2006
    ..8+/-7.7ng/mg; non-carriers: 58.6+/-2.3ng/mg; p=0.002) but not in non-demented controls. Our results suggest that PPARD haplotypes might influence levels of cholesterol metabolites in AD patients, but act not as risk factors of AD...
  88. ncbi request reprint Risk factors of major depression in the elderly
    Reinhard Heun
    Department of Psychiatry, University of Bonn, Venusberg, 53105 Bonn, Germany
    Eur Psychiatry 20:199-204. 2005
    ..Confirmation in independent samples is needed. The present follow-up study prospectively investigated risk factors of depression in an elderly German sample...
  89. ncbi request reprint Risk factors and early signs of Alzheimer's disease in a family study sample. Risk of AD
    Reinhard Heun
    Department of Psychiatry, University of Bonn, Venusberg, 53105 Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 256:28-36. 2006
    ....
  90. ncbi request reprint Investigation of a genetic variation of a variable number tandem repeat polymorphism of interleukin-6 gene in patients with multiple sclerosis
    Stephan Schmidt
    Dept of Neurology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    J Neurol 250:607-11. 2003
    ..Taken together, a disease-modifying effect of IL-6 C allele could not be demonstrated in MS patients of German Caucasian descent...
  91. ncbi request reprint Cathepsin D: screening for new polymorphisms using single-strand conformation polymorphism analysis
    Micael Majores
    Department of Psychiatry, University of Bonn, D 53105 Bonn, Germany
    Int J Mol Med 9:185-7. 2002
    ..Thus, if sequence variations within the CTSD gene influence the risk for various diseases, the pathogenic mechanism is likely to be linked to the amino acid substitution in the profragment of CTSD...
  92. ncbi request reprint Polymorphisms of the gene encoding the inflammatory cytokine interleukin-6 determine the magnitude of the increase in soluble interleukin-6 receptor levels in Alzheimer's disease. Results of a pilot study
    Metin Bagli
    Department of Psychiatry, University of Bonn, Venusberg, 53105 Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 253:44-8. 2003
    ..We conclude that plasma and CSF levels of sIL-6R are significantly increased in AD patients and that the magnitude of increase is determined by the IL-6 genotype...
  93. ncbi request reprint Regional N-acetylaspartate reduction in the hippocampus detected with fast proton magnetic resonance spectroscopic imaging in patients with Alzheimer disease
    Wolfgang Block
    Department of Radiology, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Arch Neurol 59:828-34. 2002
    ..To detect regional metabolic changes that resemble the expected spatial pattern of neuronal loss in patients with Alzheimer disease (AD)...
  94. ncbi request reprint Genetic variations and humoral immune responses to myelin oligodendroglia glycoprotein in adult phenotypes of X-linked adrenoleukodystrophy
    Stephan Schmidt
    Department of Neurology, University of Bonn, Sigmund Freud Str 20, 53105, Bonn, Germany
    J Neuroimmunol 135:148-53. 2003
    ..Anti-MOG antibodies were detectable in 17/54 X-ALD patients (31.5%). Anti-MOG antibodies were associated with the 226 bp (TAAA)(n) MOG gene polymorphism but not with distinct clinical phenotypes...
  95. ncbi request reprint Association of an interleukin-1beta gene polymorphism at position -511 with Alzheimer's disease
    Christian Ehl
    Department of Psychiatry, University of Bonn, D 53105 Bonn, Germany
    Int J Mol Med 11:235-8. 2003
    ..Even though IL-1beta -511 polymorphism did not influence the risk of AD it might have a pathophysiological influence on the disease process...
  96. ncbi request reprint Identification of a single nucleotide polymorphism in the choline acetyltransferase gene associated with Alzheimer's disease
    Victor Mubumbila
    Laboratoire de Génétique Moléculaire des Eucaryotes CNRS, Unité 184 de Biologie Moléculaire et de Génie Génétique INSERM, Faculte de Medecine, 11 rue Humann, 67085 Strasbourg, France
    Neurosci Lett 333:9-12. 2002
    ..We suggest that such a polymorphism might be one of the events conferring an increased risk for deterioration of memory and cognition functions in AD...
  97. ncbi request reprint Novelty detection and repetition suppression in a passive picture viewing task: a possible approach for the evaluation of neuropsychiatric disorders
    Frank Jessen
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Hum Brain Mapp 17:230-6. 2002
    ..Our results indicate that activation of disease-relevant brain regions under passive task conditions is possible. This might increase the utility of functional imaging in cognitively impaired patients...
  98. ncbi request reprint Test-retest reliability of self-reported age at onset of selected psychiatric diagnoses in general health care
    Katrin Barkow
    Department of Psychiatry, University of Bonn, Germany
    Acta Psychiatr Scand 106:117-25. 2002
    ..To investigate reliability of self-reported age at onset of frequent mental disorders and its association with patient and disorder characteristics...
  99. ncbi request reprint Cerebrospinal fluid levels of beta-amyloid(42) in patients with Alzheimer's disease are related to the exon 2 polymorphism of the cathepsin D gene
    Andreas Papassotiropoulos
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Neuroreport 13:1291-4. 2002
    ....
  100. ncbi request reprint Polymorphism in the BACE gene influences the risk for Alzheimer's disease
    Chartika M Kirschling
    Department of Psychiatry, University of Bonn, Germany
    Neuroreport 14:1243-6. 2003
    ..Furthermore, Abeta(42) CSF levels were influenced by BACE genotype. It appears that BACE polymorphism plays a more important role in the development of AD than previously assumed, possibly by influencing Abeta(42) levels...
  101. ncbi request reprint Reduced hippocampal activation during encoding and recognition of words in schizophrenia patients
    Frank Jessen
    Department of Psychiatry, University of Bonn, Germany
    Am J Psychiatry 160:1305-12. 2003
    ....