Swen Hesse

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. ncbi request reprint Altered serotonin transporter availability in patients with multiple sclerosis
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Liebigstraße 18, 04103, Leipzig, Germany
    Eur J Nucl Med Mol Imaging 41:827-35. 2014
  2. doi request reprint Imaging of the brain serotonin transporters (SERT) with 18F-labelled fluoromethyl-McN5652 and PET in humans
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    Eur J Nucl Med Mol Imaging 39:1001-11. 2012
  3. doi request reprint Dopamine transporter imaging in adult patients with attention-deficit/hyperactivity disorder
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    Psychiatry Res 171:120-8. 2009
  4. doi request reprint The serotonin transporter availability in untreated early-onset and late-onset patients with obsessive-compulsive disorder
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Germany
    Int J Neuropsychopharmacol 14:606-17. 2011
  5. doi request reprint Monoamine transporter availability in Parkinson's disease patients with or without depression
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Stephanstrasse 11, 04103 Leipzig, Germany
    Eur J Nucl Med Mol Imaging 36:428-35. 2009
  6. doi request reprint Effects of subthalamic nucleus stimulation on striatal dopaminergic transmission in patients with Parkinson's disease within one-year follow-up
    Swen Hesse
    Dept of Nuclear Medicine, University of Leipzig, Stephanstrasse 11, 04103 Leipzig, Germany
    J Neurol 255:1059-66. 2008
  7. ncbi request reprint Serotonin and dopamine transporter imaging in patients with obsessive-compulsive disorder
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Stephanstrasse 11, D 04103 Leipzig, Germany
    Psychiatry Res 140:63-72. 2005
  8. ncbi request reprint Concordant pre- and postsynaptic deficits of dopaminergic neurotransmission in neurologic Wilson disease
    Henryk Barthel
    Department of Nuclear Medicine, University of Leipzig, Germany
    AJNR Am J Neuroradiol 24:234-8. 2003
  9. doi request reprint Preserved serotonin transporter binding in de novo Parkinson's disease: negative correlation with the dopamine transporter
    Karl Strecker
    Department of Neurology, University of Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany
    J Neurol 258:19-26. 2011
  10. ncbi request reprint Serotonin transporter imaging with [123I]beta-CIT SPECT before and after one year of citalopram treatment of obsessive-compulsive disorder
    Katarina Stengler-Wenzke
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Neuropsychobiology 53:40-5. 2006

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Altered serotonin transporter availability in patients with multiple sclerosis
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Liebigstraße 18, 04103, Leipzig, Germany
    Eur J Nucl Med Mol Imaging 41:827-35. 2014
    ..Central serotonergic mechanisms have not been investigated in MS by in vivo imaging. The objective of the study was to assess the availability of SERT in antidepressant-naive patients with MS by means of PET...
  2. doi request reprint Imaging of the brain serotonin transporters (SERT) with 18F-labelled fluoromethyl-McN5652 and PET in humans
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    Eur J Nucl Med Mol Imaging 39:1001-11. 2012
    ..The aim of our study was to firstly use the new highly SERT-selective (18)F-labelled fluoromethyl analogue of (+)-McN5652 ((+)-[(18)F]FMe-McN5652) in humans and to evaluate its potential for SERT quantification...
  3. doi request reprint Dopamine transporter imaging in adult patients with attention-deficit/hyperactivity disorder
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    Psychiatry Res 171:120-8. 2009
    ..Further studies will have to deal with the question of whether these findings have the potential to influence treatment decisions in this complex disorder...
  4. doi request reprint The serotonin transporter availability in untreated early-onset and late-onset patients with obsessive-compulsive disorder
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Germany
    Int J Neuropsychopharmacol 14:606-17. 2011
    ..These findings suggest that late but not early onset of OCD is associated with abnormally low SERT availability. In part, functional polymorphisms of the SERT gene might determine the differences...
  5. doi request reprint Monoamine transporter availability in Parkinson's disease patients with or without depression
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Stephanstrasse 11, 04103 Leipzig, Germany
    Eur J Nucl Med Mol Imaging 36:428-35. 2009
    ..Therefore, we studied PD patients with depression (PD+D) and without depression (PD-D) using high-resolution single-photon emission computed tomography (SPECT) and the monoamine transporter marker [(123)I]FP-CIT...
  6. doi request reprint Effects of subthalamic nucleus stimulation on striatal dopaminergic transmission in patients with Parkinson's disease within one-year follow-up
    Swen Hesse
    Dept of Nuclear Medicine, University of Leipzig, Stephanstrasse 11, 04103 Leipzig, Germany
    J Neurol 255:1059-66. 2008
    ..These data show that clinical improvement and reduction of dopaminergic drugs in patients with advanced PD undergoing bilateral STN-DBS are paralleled by stable DAT and recovery of striatal D2R availability 12 months after surgery...
  7. ncbi request reprint Serotonin and dopamine transporter imaging in patients with obsessive-compulsive disorder
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Stephanstrasse 11, D 04103 Leipzig, Germany
    Psychiatry Res 140:63-72. 2005
    ..Our data provide evidence for imbalanced monoaminergic neurotransmitter modulation in OCD. Further studies with more selective DAT and SERT radiotracers are needed...
  8. ncbi request reprint Concordant pre- and postsynaptic deficits of dopaminergic neurotransmission in neurologic Wilson disease
    Henryk Barthel
    Department of Nuclear Medicine, University of Leipzig, Germany
    AJNR Am J Neuroradiol 24:234-8. 2003
    ..The present study was initiated to intra-individually determine the integrity of these compartments in patients with WD...
  9. doi request reprint Preserved serotonin transporter binding in de novo Parkinson's disease: negative correlation with the dopamine transporter
    Karl Strecker
    Department of Neurology, University of Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany
    J Neurol 258:19-26. 2011
    ..No alteration of SERT binding in our patients suggests that the serotonergic system is remarkably preserved in early PD. Correlation with DAT might point to a compensatory regulation of the serotonergic system in early stages of PD...
  10. ncbi request reprint Serotonin transporter imaging with [123I]beta-CIT SPECT before and after one year of citalopram treatment of obsessive-compulsive disorder
    Katarina Stengler-Wenzke
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Neuropsychobiology 53:40-5. 2006
    ..The neurobiological mechanisms of SSRI action and failure to respond to SSRI treatment remain to be elucidated...
  11. doi request reprint Individualized quantification of brain β-amyloid burden: results of a proof of mechanism phase 0 florbetaben PET trial in patients with Alzheimer's disease and healthy controls
    Henryk Barthel
    Department of Nuclear Medicine, University of Leipzig, Liebigstr 18, 04103 Leipzig, Germany
    Eur J Nucl Med Mol Imaging 38:1702-14. 2011
    ..The value of various quantitative parameters derived from the PET scans as potential surrogate markers of cognitive decline was also investigated...
  12. ncbi request reprint Is correction for age necessary in neuroimaging studies of the central serotonin transporter?
    Swen Hesse
    Department of Nuclear Medicine, University of Leipzig, Germany
    Eur J Nucl Med Mol Imaging 30:427-30. 2003
    ..From these results we conclude that age-related changes in SERT density need to be considered in future clinical studies...
  13. doi request reprint Reduced alpha4beta2*-nicotinic acetylcholine receptor binding and its relationship to mild cognitive and depressive symptoms in Parkinson disease
    Philipp M Meyer
    Department of Nuclear Medicine, University of Leipzig, Liebigstr 18, 04103 Leipzig, Germany
    Arch Gen Psychiatry 66:866-77. 2009
    ..Cognitive or depressive disorders are frequently noted in patients with Parkinson disease (PD) and may be related to altered signaling through alpha4beta2*-nicotinic acetylcholine receptors (alpha4beta2*-nAChRs)...
  14. ncbi request reprint Reduced serotonin transporter-availability in obsessive-compulsive disorder (OCD)
    Katarina Stengler-Wenzke
    Dept of Psychiatry, University of Leipzig, Johannisallee 20, 04317 Leipzig, Germany
    Eur Arch Psychiatry Clin Neurosci 254:252-5. 2004
    ..76 (OCD patients) and 3.53 +/- 1.01 (controls). This in vivo finding of significant reduced serotonin transporter availability in midbrain/brainstem using [(123)I] beta-CIT SPECT further supports the serotonin deficit hypothesis of OCD...
  15. doi request reprint Influence of scan duration on the accuracy of β-amyloid PET with florbetaben in patients with Alzheimer's disease and healthy volunteers
    Solveig Tiepolt
    Department of Nuclear Medicine, University of Leipzig, Liebigstr 18, 04103 Leipzig, Germany
    Eur J Nucl Med Mol Imaging 40:238-44. 2013
    ..In dementia imaging, shortening of scan duration may simplify future clinical use. The aim of this retrospective study was to investigate the effect of scan duration on diagnostic accuracy...
  16. doi request reprint Decreased cerebral α4β2* nicotinic acetylcholine receptor availability in patients with mild cognitive impairment and Alzheimer's disease assessed with positron emission tomography
    Kai Kendziorra
    Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany
    Eur J Nucl Med Mol Imaging 38:515-25. 2011
    ....
  17. ncbi request reprint Advances in in vivo imaging of serotonergic neurons in neuropsychiatric disorders
    Swen Hesse
    Department of Nuclear Medicine, University Hospital, University of Leipzig, Leipzig, Germany
    Neurosci Biobehav Rev 28:547-63. 2004
    ..We furthermore elucidate the potential of SERT imaging techniques in estimating the effect of selective serotonin reuptake-inhibitors...
  18. doi request reprint Kinetic analyses of [123I]IBZM SPECT for quantification of striatal dopamine D2 receptor binding: a critical evaluation of the single-scan approach
    Philipp T Meyer
    Department of Nuclear Medicine, University Hospital Aachen, Aachen, Germany
    Neuroimage 42:548-58. 2008
    ..The present study addresses these shortcomings...
  19. doi request reprint Impact of EEG-vigilance on brain glucose uptake measured with [(18)F]FDG and PET in patients with depressive episode or mild cognitive impairment
    Thomas Guenther
    Department of Psychiatry and Psychotherapy, University Hospital Leipzig, Semmelweisstr 10, 04103 Leipzig, Germany
    Neuroimage 56:93-101. 2011
    ..For the first time, the present study exploratively investigated this association in a routine diagnostic work-up...
  20. ncbi request reprint Correlation between automated writing movements and striatal dopaminergic innervation in patients with Wilson's disease
    Wieland Hermann
    Department of Neurology, University of Leipzig, Liebigstr 22a, 04107 Leipzig, Germany
    J Neurol 249:1082-7. 2002
    ..Furthermore analysis of automated handwriting movements could be useful for therapy monitoring and evaluation of striatal dopaminergic innervation...
  21. ncbi request reprint Evaluation of metabolism, plasma protein binding and other biological parameters after administration of (-)-[(18)F]Flubatine in humans
    Marianne Patt
    Department of Nuclear Medicine, University of Leipzig, Liebigstrasse 18, D 04103 Leipzig, Germany Electronic address
    Nucl Med Biol 41:489-94. 2014
    ..From a total participant number of 21 Alzheimer's disease (AD) patients and 20 healthy controls (HCs), the following parameters were determined: plasma protein binding, metabolism and activity distribution between plasma and whole blood...