Johannes M Herrmann

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. pmc Mba1, a novel component of the mitochondrial protein export machinery of the yeast Saccharomyces cerevisiae
    M Preuss
    Insitute for Phyisiological Chemistry, Goethestrasse 33, 80336 Munich, Germany
    J Cell Biol 153:1085-96. 2001
  2. ncbi request reprint Biogenesis of cytochrome oxidase-sophisticated assembly lines in the mitochondrial inner membrane
    Johannes M Herrmann
    Institute of Physiological Chemistry, Butenandtstrasse 5, 81377 Munchen, University of Munich, Germany
    Gene 354:43-52. 2005
  3. ncbi request reprint Chopped, trapped or tacked--protein translocation into the IMS of mitochondria
    Johannes M Herrmann
    Institut fur Physiologische Chemie, Universitat Munchen, Butenandtstrasse 5, 81377 Munich, Germany
    Trends Biochem Sci 30:205-11. 2005
  4. ncbi request reprint Protein export across the inner membrane of mitochondria: the nature of translocated domains determines the dependence on the Oxa1 translocase
    Johannes M Herrmann
    Institut fur Physiologische Chemie, Universitat Munchen, Butenandtstrasse 5, München 81377, Germany
    J Biol Chem 279:2507-12. 2004
  5. ncbi request reprint A disulfide relay system in the intermembrane space of mitochondria that mediates protein import
    Nikola Mesecke
    Institute für Physiologische Chemie, Universitat Munchen, Germany
    Cell 121:1059-69. 2005
  6. pmc Independent gene duplications of the YidC/Oxa/Alb3 family enabled a specialized cotranslational function
    Soledad Funes
    Gene Center, Department of Chemistry and Biochemistry, University of Munich, Feodor Lynen Strasse 25, 81377 Munich, Germany
    Proc Natl Acad Sci U S A 106:6656-61. 2009
  7. pmc Mba1, a membrane-associated ribosome receptor in mitochondria
    Martin Ott
    Institut fur Physiologische Chemie, Universitat Munchen, Munchen, Germany
    EMBO J 25:1603-10. 2006
  8. ncbi request reprint Evolution of mitochondrial oxa proteins from bacterial YidC. Inherited and acquired functions of a conserved protein insertion machinery
    Marc Preuss
    Institut fur Physiologische Chemie, Universitat Munchen, Butenandtstrasse 5, 81377 Munchen, Germany
    J Biol Chem 280:13004-11. 2005
  9. ncbi request reprint Conserved N-terminal negative charges in the Tim17 subunit of the TIM23 translocase play a critical role in the import of preproteins into mitochondria
    Stephan Meier
    Institut fur Physiologische Chemie, Universitat Munchen, Butenandtstrasse 5, 81377 Munchen, Germany
    J Biol Chem 280:7777-85. 2005
  10. pmc Proline residues of transmembrane domains determine the sorting of inner membrane proteins in mitochondria
    Stephan Meier
    Institut fur Physiologische Chemie, Universitat Munchen, 81377 Munich, Germany
    J Cell Biol 170:881-8. 2005

Collaborators

Detail Information

Publications39

  1. pmc Mba1, a novel component of the mitochondrial protein export machinery of the yeast Saccharomyces cerevisiae
    M Preuss
    Insitute for Phyisiological Chemistry, Goethestrasse 33, 80336 Munich, Germany
    J Cell Biol 153:1085-96. 2001
    ..We conclude that Mba1 is part of the mitochondrial protein export machinery and represents the first component of a novel Oxa1-independent insertion pathway into the mitochondrial inner membrane...
  2. ncbi request reprint Biogenesis of cytochrome oxidase-sophisticated assembly lines in the mitochondrial inner membrane
    Johannes M Herrmann
    Institute of Physiological Chemistry, Butenandtstrasse 5, 81377 Munchen, University of Munich, Germany
    Gene 354:43-52. 2005
    ..We propose that these chaperones, Mss51 for subunit 1 and Cox20 for subunit 2, control the coordinate assembly process to prevent potentially harmful redox reactions of unassembled or misassembled subunits...
  3. ncbi request reprint Chopped, trapped or tacked--protein translocation into the IMS of mitochondria
    Johannes M Herrmann
    Institut fur Physiologische Chemie, Universitat Munchen, Butenandtstrasse 5, 81377 Munich, Germany
    Trends Biochem Sci 30:205-11. 2005
    ..The second class depends on the energy gain of protein folding, and the third on the association of the proteins to high-affinity binding sites in the IMS...
  4. ncbi request reprint Protein export across the inner membrane of mitochondria: the nature of translocated domains determines the dependence on the Oxa1 translocase
    Johannes M Herrmann
    Institut fur Physiologische Chemie, Universitat Munchen, Butenandtstrasse 5, München 81377, Germany
    J Biol Chem 279:2507-12. 2004
    ..Our observations rather suggest that the dependence on Oxa1 correlates with the net charge of the domain that has to be translocated across the lipid bilayer...
  5. ncbi request reprint A disulfide relay system in the intermembrane space of mitochondria that mediates protein import
    Nikola Mesecke
    Institute für Physiologische Chemie, Universitat Munchen, Germany
    Cell 121:1059-69. 2005
    ..We suggest that this process reflects the evolutionary origin of the IMS from the periplasmic space of the prokaryotic ancestors of mitochondria...
  6. pmc Independent gene duplications of the YidC/Oxa/Alb3 family enabled a specialized cotranslational function
    Soledad Funes
    Gene Center, Department of Chemistry and Biochemistry, University of Munich, Feodor Lynen Strasse 25, 81377 Munich, Germany
    Proc Natl Acad Sci U S A 106:6656-61. 2009
    ..Our results are consistent with a gene-duplication event in gram-positive bacteria that enabled the specialization of a YidC isoform that mediates cotranslational activity independent of an SRP pathway...
  7. pmc Mba1, a membrane-associated ribosome receptor in mitochondria
    Martin Ott
    Institut fur Physiologische Chemie, Universitat Munchen, Munchen, Germany
    EMBO J 25:1603-10. 2006
    ..We propose that Mba1 functions as a ribosome receptor that cooperates with Oxa1 in the positioning of the ribosome exit site to the insertion machinery of the inner membrane...
  8. ncbi request reprint Evolution of mitochondrial oxa proteins from bacterial YidC. Inherited and acquired functions of a conserved protein insertion machinery
    Marc Preuss
    Institut fur Physiologische Chemie, Universitat Munchen, Butenandtstrasse 5, 81377 Munchen, Germany
    J Biol Chem 280:13004-11. 2005
    ..Our observations suggest that during evolution of mitochondria from their bacterial ancestors the two descendents of YidC functionally segregated to perform two distinct activities, one co-translational and one post-translational...
  9. ncbi request reprint Conserved N-terminal negative charges in the Tim17 subunit of the TIM23 translocase play a critical role in the import of preproteins into mitochondria
    Stephan Meier
    Institut fur Physiologische Chemie, Universitat Munchen, Butenandtstrasse 5, 81377 Munchen, Germany
    J Biol Chem 280:7777-85. 2005
    ..On the basis of these observations we propose that charged residues in Tim17 are critical for the preprotein-induced gating of the TIM23 translocase...
  10. pmc Proline residues of transmembrane domains determine the sorting of inner membrane proteins in mitochondria
    Stephan Meier
    Institut fur Physiologische Chemie, Universitat Munchen, 81377 Munich, Germany
    J Cell Biol 170:881-8. 2005
    ..We propose that proline residues, together with the hydrophobicity of the TMD and the presence of charged residues COOH-terminally flanking the TMD, are determinants of the intramitochondrial sorting of inner membrane proteins...
  11. pmc The zinc-binding protein Hot13 promotes oxidation of the mitochondrial import receptor Mia40
    Nikola Mesecke
    Institut fur Physiologische Chemie, Universitat Munchen, Butenandtstrasse 5, 81377 Munchen, Germany
    EMBO Rep 9:1107-13. 2008
    ..In mitochondria as well as in vitro, Hot13 can be functionally replaced by zinc-binding chelators. We propose that Hot13 maintains Mia40 in a zinc-free state, thereby facilitating its efficient oxidation by Erv1...
  12. ncbi request reprint Synthesis and sorting of mitochondrial translation products
    Heike Bauerschmitt
    Adolf Butenandt Institute of Physiological Chemistry, University of Munich, Munich, Germany
    Methods Mol Biol 457:95-112. 2008
    ..The methods described here can be applied also to the study of other aspects of organelle biogenesis such as folding, assembly, and degradation of proteins...
  13. ncbi request reprint Mia40, a novel factor for protein import into the intermembrane space of mitochondria is able to bind metal ions
    Nadia Terziyska
    Adolf Butenandt Institut für Physiologische Chemie, Ludwig Maximilians Universitat Munchen, Butenandtstrasse 5, D 81377 Munchen, Germany
    FEBS Lett 579:179-84. 2005
    ..Furthermore, Mia40 directly interacts with newly imported Tim13 protein. We conclude that Mia40 is the first essential component of a specific translocation pathway of metal-binding IMS proteins...
  14. doi request reprint The membrane-bound GTPase Guf1 promotes mitochondrial protein synthesis under suboptimal conditions
    Heike Bauerschmitt
    Institute of Physiological Chemistry, University of Munich, 81377 Munich, Germany
    J Biol Chem 283:17139-46. 2008
    ..These observations show a critical role for Guf1 in vivo. The observed defects in Guf1-deficient mitochondria are consistent with a function of Guf1 as a fidelity factor of mitochondrial protein synthesis...
  15. ncbi request reprint Translocation of proteins into mitochondria
    Walter Neupert
    Institut fur Physiologische Chemie, Universitat Munchen, 81377 Munchen, Germany
    Annu Rev Biochem 76:723-49. 2007
    ..This review summarizes the present knowledge on the import and sorting of mitochondrial precursor proteins, with a special emphasis on unresolved questions and topics of current research...
  16. pmc Ribosome binding to the Oxa1 complex facilitates co-translational protein insertion in mitochondria
    Gregor Szyrach
    Institut fur Physiologische Chemie, Butenandtstrasse 5, D 81377 Munchen, Germany
    EMBO J 22:6448-57. 2003
    ..This suggests that co-translational membrane insertion of mitochondrial translation products is facilitated by a physical interaction of translation complexes with the membrane-bound translocase...
  17. pmc A novel group of glutaredoxins in the cis-Golgi critical for oxidative stress resistance
    Nikola Mesecke
    Institute of Physiological Chemistry, University of Munich, 81377 Munich, Germany
    Mol Biol Cell 19:2673-80. 2008
    ..Our observations suggest that Grx6 and Grx7 do not play a general role in the oxidative folding of proteins in the early secretory pathway but rather counteract the oxidation of specific thiol groups in substrate proteins...
  18. ncbi request reprint The sulfhydryl oxidase Erv1 is a substrate of the Mia40-dependent protein translocation pathway
    Nadia Terziyska
    Adolf Butenandt Institut für Physiologische Chemie, Ludwig Maximilians Universitat Munchen, Butenandtstrasse 5, D 81377 Munchen, Germany
    FEBS Lett 581:1098-102. 2007
    ..Thus, Erv1 represents an unusual type of substrate of the Mia40-dependent import pathway...
  19. pmc Import of small Tim proteins into the mitochondrial intermembrane space
    Thomas Lutz
    Institut fur Physiologische Chemie, Universitat Munchen, Butenandtstrasse 5, 81377 Munchen, Germany
    EMBO J 22:4400-8. 2003
    ....
  20. ncbi request reprint Insertion of bitopic membrane proteins into the inner membrane of mitochondria involves an export step from the matrix
    Frank Baumann
    Institut fur Physiologische Chemie, Butenandtstrasse 5, 81377 Munchen, Germany
    J Biol Chem 277:21405-13. 2002
    ....
  21. ncbi request reprint Converting bacteria to organelles: evolution of mitochondrial protein sorting
    Johannes M Herrmann
    Institut fur Physiologische Chemie, Universitat Munchen, Butenandtstrasse 5, 81377 Munich, Germany
    Trends Microbiol 11:74-9. 2003
    ..The requirement for post-translational transport to their final destination has placed considerable constraints on the evolution of mitochondrial protein sequences...
  22. ncbi request reprint Analysis of mitochondrial protein synthesis in yeast
    Soledad Funes
    Institut fur Physiologische Chemie, Ludwig Maximilians Universitat Munchen, Germany
    Methods Mol Biol 372:255-63. 2007
    ....
  23. ncbi request reprint The Arabidopsis thaliana chloroplast inner envelope protein ARTEMIS is a functional member of the Alb3/Oxa1/YidC family of proteins
    Soledad Funes
    Institut fur Physiologische Chemie, Ludwig Maximilians Universitat Munchen, Butenandtstrasse 5, 81377 Munchen, Germany
    FEBS Lett 569:89-93. 2004
    ....
  24. ncbi request reprint Saccharomyces cerevisiae Cox18 complements the essential Sec-independent function of Escherichia coli YidC
    Edwin van Bloois
    Department of Molecular Microbiology, Institute of Molecular Cell Biology, Vrije Universiteit, Amsterdam, The Netherlands
    FEBS J 274:5704-13. 2007
    ..coli, we show here that Cox18 is able to complement the essential Sec-independent function of YidC. This identifies Cox18 as a bona fide member of the YidC/Oxa1/Alb3 family...
  25. doi request reprint New insights into the mechanism of precursor protein insertion into the mitochondrial membranes
    Markus Hildenbeutel
    Cell Biology, University of Kaiserslautern, 67663 Kaiserslautern, Germany
    Int Rev Cell Mol Biol 268:147-90. 2008
    ....
  26. ncbi request reprint Analysis of protein-protein interactions in mitochondria
    Johannes M Herrmann
    Institut fur Zellbiologie, Universitat Kaiserslautern, 67663 Kaiserslautern, Germany
    Methods Cell Biol 80:743-59. 2007
  27. pmc The disulfide relay system of mitochondria is connected to the respiratory chain
    Karl Bihlmaier
    Department of Cell Biology, University of Kaiserslautern, Kaiserslautern 67663, Germany
    J Cell Biol 179:389-95. 2007
    ..Thus, analogous to the system in the bacterial periplasm, the disulfide relay in the intermembrane space is connected to the electron transport chain of the inner membrane...
  28. pmc Catch me if you can! Oxidative protein trapping in the intermembrane space of mitochondria
    Johannes M Herrmann
    Department of Cell Biology, University of Kaiserslautern, 67663 Kaiserslautern, Germany
    J Cell Biol 176:559-63. 2007
    ..The principle of protein oxidation in the IMS presumably has been conserved from the bacterial periplasm and has been adapted during evolution to drive the vectorial translocation of proteins from the cytosol into the mitochondria...
  29. pmc Suppression of coatomer mutants by a new protein family with COPI and COPII binding motifs in Saccharomyces cerevisiae
    Thomas Sandmann
    Friedrich Miescher Laboratorium der Max Planck Gesellschaft, D 72076 Tubingen, Germany
    Mol Biol Cell 14:3097-113. 2003
    ..As a consequence, the amount of cargo that can bind COPI might be important for the regulation of the vesicle flow in the early secretory pathway...
  30. pmc The Oxa2 protein of Neurospora crassa plays a critical role in the biogenesis of cytochrome oxidase and defines a ubiquitous subbranch of the Oxa1/YidC/Alb3 protein family
    Soledad Funes
    Institut fur Physiologische Chemie, Universitat Munchen, 81377 Munchen, Germany
    Mol Biol Cell 15:1853-61. 2004
    ..The oxa2 sequence allowed the identification of a new subfamily of Oxa1/YidC/Alb3 proteins whose members appear to be ubiquitously present in mitochondria of fungi, plants, and animals including humans...
  31. ncbi request reprint Atp10p assists assembly of Atp6p into the F0 unit of the yeast mitochondrial ATPase
    Alexander Tzagoloff
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    J Biol Chem 279:19775-80. 2004
    ..Based on these observations, we propose Atp10p to be an Atp6p-specific chaperone that facilitates the incorporation of Atp6p into an intermediate subcomplex of ATPase subunits...
  32. ncbi request reprint The Sec-independent function of Escherichia coli YidC is evolutionary-conserved and essential
    Edwin van Bloois
    Department of Molecular Microbiology, Institute of Molecular Cell Biology, Vrije Universiteit, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands
    J Biol Chem 280:12996-3003. 2005
    ..Together, our data indicate that the Sec-independent function of YidC is conserved and essential for cell growth...
  33. ncbi request reprint Protein insertion into the inner membrane of mitochondria
    Johannes M Herrmann
    Institut fur Physiologische Chemie, Butenandt 5, 81377 Munchen, Germany
    IUBMB Life 55:219-25. 2003
    ..Two of these pathways depend on the related inner membrane proteins Oxa1 and Cox18. A third route is less well defined and depends on the membrane-associated matrix protein Mba1...
  34. ncbi request reprint The Oxa1 protein forms a homooligomeric complex and is an essential part of the mitochondrial export translocase in Neurospora crassa
    Frank E Nargang
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada
    J Biol Chem 277:12846-53. 2002
    ..Since the Oxa1 monomer has a molecular weight of 43,000, our data suggest that the OXA translocase consists of a homooligomer most likely containing four Oxa1 subunits...
  35. pmc Sequential processing of a mitochondrial tandem protein: insights into protein import in Schizosaccharomyces pombe
    Oleh Khalimonchuk
    Institut fur Genetik, Technische Universitat Dresden, Germany
    Eukaryot Cell 5:997-1006. 2006
    ..pombe...
  36. ncbi request reprint Tim17p regulates the twin pore structure and voltage gating of the mitochondrial protein import complex TIM23
    Sonia Martinez-Caballero
    Department of Basic Sciences, New York University College of Dentistry, New York, New York 10010, USA
    J Biol Chem 282:3584-93. 2007
    ..These results suggest that although Tim23p is the main structural unit of the pore Tim17p is required for twin pore structure and provides the voltage gate for the TIM23 channel...
  37. ncbi request reprint Mitochondrial targeting signals and mature peptides of 3-methylcrotonyl-CoA carboxylase
    Sonja C Stadler
    Dr von Hauner Children s Hospital, Department of Biochemical Genetics and Molecular Biology, Ludwig Maximilians University, Munich, Germany
    Biochem Biophys Res Commun 334:939-46. 2005
    ..Structural requirements for mitochondrial import were defined by site-directed mutagenesis. Our studies provide the prerequisite to understand the impact of specific mutations on the clinical phenotype of MCC deficiency...
  38. pmc Special issue: redox regulation of protein folding. Preface
    Johannes M Herrmann
    Biochim Biophys Acta 1783:519. 2008
  39. doi request reprint Two novel monothiol glutaredoxins from Saccharomyces cerevisiae provide further insight into iron-sulfur cluster binding, oligomerization, and enzymatic activity of glutaredoxins
    Nikola Mesecke
    Adolf Butenandt Institut für Physiologische Chemie, Ludwig Maximilians Universität D 81377, Munchen, Germany
    Biochemistry 47:1452-63. 2008
    ..Such different properties presumably reflect diverse functions in vivo and might therefore explain why there are at least seven glutaredoxins in yeast...