Affiliation: University of Hamburg
- Identification and characterization of SorCS, a third member of a novel receptor familyG Hermey
Zentrum für Molekulare Neurobiologie, Universitat Hamburg, Martinistrasse 52, Hamburg, 20246, Germany
Biochem Biophys Res Commun 266:347-51. 1999..SorCS is predominantly expressed in brain, but also in heart, liver, and kidney. SorCS transcripts detected by in situ hybridization in the murine central nervous system point to a neuronal expression...
- Alternative splicing of murine SorCS leads to two forms of the receptor that differ completely in their cytoplasmic tailsG Hermey
Zentrum für Molekulare Neurobiologie, Universitat Hamburg, Martinistr 52, 20246, Hamburg, Germany
Biochim Biophys Acta 1491:350-4. 2000..In contrast to the known intracellular regions of the related receptors, this splice variant contains no internalization or sorting signals...
- SorCS1, a member of the novel sorting receptor family, is localized in somata and dendrites of neurons throughout the murine brainG Hermey
, , Martinistrasse 52, D-20246 Hamburg, Germany
Neurosci Lett 313:83-7. 2001..This suggests variable functions for sorCS1 in the neurons of the brain...
- Identification of SorCS2, a novel member of the VPS10 domain containing receptor family, prominently expressed in the developing mouse brainM Rezgaoui
Zentrum für Molekulare Neurobiologie, Universitat Hamburg, Martinistrasse 52, D 20246, Hamburg, Germany
Mech Dev 100:335-8. 2001..Outside the nervous system expression is detected in lung and heart and transiently in a variety of mesodermally derived tissues...
- Transient expression of SorCS in developing telencephalic and mesencephalic structures of the mouseG Hermey
Zentrum für Molekulare Neurobiologie, Universitat Hamburg, Germany
Neuroreport 12:29-32. 2001..Transcripts were absent from fiber tracts hinting at a neuronal expression. The only exception was hybridization signals on the developing optic nerve correlating with the appearance of astrocytes migrating into the retina...
- Expression of the 100-kDa neurotensin receptor sortilin during mouse embryonal developmentI Hermans-Borgmeyer
Zentrum für Molekulare Neurobiologie, University of Hamburg, Martinistr 52, D 20246, Hamburg, Germany
Brain Res Mol Brain Res 65:216-9. 1999..We show that the nervous system is the main location of sortilin gene expression and that with ongoing development the forebrain exhibits the highest accumulation of transcripts...
- Identification of a novel seven-transmembrane receptor with homology to glycoprotein receptors and its expression in the adult and developing mouseG Hermey
Zentrum für Molekulare Neurobiologie, University of Hamburg, Martinistrasse 52, Hamburg, 20246, Germany
Biochem Biophys Res Commun 254:273-9. 1999..Because fex was expressed during periods of active morphogenesis, it may be an important receptor for signals controlling growth and differentiation of specific embryonic tissues...
- A novel G protein-coupled receptor with homology to neuropeptide and chemoattractant receptors expressed during bone developmentA Methner
Center for Molecular Neurobiology, University of Hamburg, Germany
Biochem Biophys Res Commun 233:336-42. 1997..It was also detectable in the adult parathyroid glands, hinting at a possible function in bone metabolism...