Genomes and Genes
Affiliation: University of Munich
- Overexpression of a dominant negative GIP receptor in transgenic mice results in disturbed postnatal pancreatic islet and beta-cell developmentNadja Herbach
Institute of Veterinary Pathology, Veterinaerstrasse 13, 80539 Munich, Germany
Regul Pept 125:103-17. 2005..These findings demonstrate in vivo evidence that intact signaling of G-protein coupled receptors is involved in postnatal islet and beta-cell development and neogenesis of the pancreatic islets...
- Postnatal development of numbers and mean sizes of pancreatic islets and beta-cells in healthy mice and GIPR(dn) transgenic diabetic miceNadja Herbach
Institute of Veterinary Pathology, Center for Clinical Veterinary Medicine, LMU Munich, Germany
PLoS ONE 6:e22814. 2011..GIPR(dn) transgenic mice show a disturbed expansion of the endocrine pancreas, due to perturbed islet neogenesis...
- Diabetic kidney lesions of GIPRdn transgenic mice: podocyte hypertrophy and thickening of the GBM precede glomerular hypertrophy and glomerulosclerosisNadja Herbach
Institute of Veterinary Pathology, Veterinaerstr 13, 80539 Munich, Germany
Am J Physiol Renal Physiol 296:F819-29. 2009..GIPR(dn) transgenic mice are considered an excellent new tool to study the mechanisms involved in onset and progression of diabetic nephropathy...
- Dominant-negative effects of a novel mutated Ins2 allele causes early-onset diabetes and severe beta-cell loss in Munich Ins2C95S mutant miceNadja Herbach
Institute of Veterinary Pathology, University of Munich, Munich, Germany
Diabetes 56:1268-76. 2007..Thus, Munich Ins2(C95S) mutant mice are considered a valuable model to study the mechanisms of beta-cell dysfunction and death during the development of diabetes...
- Diets influence the diabetic phenotype of transgenic mice expressing a dominant negative glucose-dependent insulinotropic polypeptide receptor (GIPRdn)Nadja Herbach
Institute of Veterinary Pathology, Veterinaerstr 13, 80539 Munich, Germany
Regul Pept 146:260-70. 2008..GIPR(dn) transgenic mice develop a severe diabetic phenotype which can be ameliorated by a HF diet, thereby resembling some aspects of the pathophysiology of human type 2 diabetes mellitus...
- Erythropoietin administration after myocardial infarction in mice attenuates ischemic cardiomyopathy associated with enhanced homing of bone marrow-derived progenitor cells via the CXCR-4/SDF-1 axisStefan Brunner
Klinikum Grosshadern, Medical Department I, Munich, Germany
FASEB J 23:351-61. 2009..However, EPO has no beneficial effects on resident CSCs. Therefore, new treatment regimes using EPO together with other agents may combine complementary beneficial effects preventing ischemic cardiomyopathy...
- Specific transgene expression in mouse pancreatic beta-cells under the control of the porcine insulin promoterMarjeta Grzech
Chair for Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Feodor Lynen Str 25, 81377 Munich, Germany
Mol Cell Endocrinol 315:219-24. 2010..We conclude that the newly designed expression cassette containing 1500bp of the porcine insulin promoter 5' UTR confers robust and specific transgene expression to beta-cells in vitro and in transgenic mice...
- Permanent neonatal diabetes in INS(C94Y) transgenic pigsSimone Renner
Chair for Molecular Animal Breeding and Biotechnology, Ludwig Maximilian University Munich, Munich, Germany
Diabetes 62:1505-11. 2013....
- Screening for increased plasma urea levels in a large-scale ENU mouse mutagenesis project reveals kidney disease modelsBernhard Aigner
Institute of Molecular Animal Breeding and BiotechnologyInstitute of Molecular Animal Breeding and Biotechnology, Ludwig Maximilians University, Munich, Germany
Am J Physiol Renal Physiol 292:F1560-7. 2007....
- The cardioprotective effects of parathyroid hormone are independent of endogenous granulocyte-colony stimulating factor releaseStefan Brunner
Department of Internal Medicine I, Ludwig Maximilians University, Campus Grosshadern, Munich, Germany
Cardiovasc Res 93:330-9. 2012..PTH-related stem cell mobilization was shown to be related to endogenous granulocyte-colony stimulating factor (G-CSF) release. The aim of our study is to determine the role of G-CSF on the cardioprotective effects of PTH...
- Systemic overexpression of growth hormone (GH) in transgenic FVB/N inbred mice: an optimized model for holistic studies of molecular mechanisms underlying GH-induced kidney pathologyDagmar C von Waldthausen
Institute of Molecular Animal Breeding and Biotechnology and Laboratory for Functional Genome Analysis LAFUGA, Gene Center, LMU Munich, Feodor Lynen Strasse 25, Munich, Germany
Transgenic Res 17:479-88. 2008..Moreover, genetically defined cbetaa-bGH mice facilitate random mutagenesis screens for modifier genes which influence the effects of chronic GH excess and associated pathological lesions...
- Glucose intolerance and reduced proliferation of pancreatic beta-cells in transgenic pigs with impaired glucose-dependent insulinotropic polypeptide functionSimone Renner
Chair for Molecular Animal Breeding and Biotechnology and Laboratory for Functional Genome Analysis, Gene Center, Ludwig Maximilians University LMU Munich, Munich, Germany
Diabetes 59:1228-38. 2010....
- Synergy between CD26/DPP-IV inhibition and G-CSF improves cardiac function after acute myocardial infarctionMarc Michael Zaruba
Medical Department I, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
Cell Stem Cell 4:313-23. 2009..Therefore, we propose pharmacological DPP-IV inhibition and G-CSF-based stem cell mobilization as a therapeutic concept for future stem cell trials after myocardial infarction...
- Differential glomerular proteome analysis of two murine nephropathy models at onset of albuminuriaAndreas Blutke
Institute of Veterinary Pathology, Ludwig Maximilians Universitaet München, Germany
Proteomics Clin Appl 5:375-81. 2011..The purpose of the present study was to identify protein biomarker candidates for these glomerular alterations...
- Growth analysis of the mouse adrenal gland from weaning to adulthood: time- and gender-dependent alterations of cell size and number in the cortical compartmentMax Bielohuby
Institute of Molecular Animal Breeding and Biotechnology, Ludwig Maximilians University, Munich, Germany
Am J Physiol Endocrinol Metab 293:E139-46. 2007..These factors require careful consideration in studies aiming at the functional dissection of genetic and environmental factors affecting adrenal growth and function...
- Xenografted islet cell clusters from INSLEA29Y transgenic pigs rescue diabetes and prevent immune rejection in humanized miceNikolai Klymiuk
Chair for Molecular Animal Breeding and Biotechnology, and Laboratory for Functional Genome Analysis, Gene Center, Ludwig Maximilians Universitat, Munich, Germany
Diabetes 61:1527-32. 2012..This approach may represent a major step toward the development of a novel strategy for pig-to-human islet transplantation without side effects of systemic immunosuppression...
- First inducible transgene expression in porcine large animal modelsNikolai Klymiuk
Ludwig Maximilians Universitat Munchen, Munich, Germany
FASEB J 26:1086-99. 2012..Our strategy revealed the first two examples of inducible transgene expression in pigs. The CAG-TA transgenic pigs generated in this study constitute an interesting basis for future pig models with inducible transgene expression...
- Betacellulin overexpression in transgenic mice causes disproportionate growth, pulmonary hemorrhage syndrome, and complex eye pathologyMarlon R Schneider
Institute of Molecular Animal Breeding and Biotechnology, Gene Center, University of Munich, Germany
Endocrinology 146:5237-46. 2005..Thus, our model uncovers multiple consequences of BTC overexpression in vivo. These transgenic mice provide a useful model for examining the effects of BTC excess on different organs...
- Parathyroid hormone treatment after myocardial infarction promotes cardiac repair by enhanced neovascularization and cell survivalMarc Michael Zaruba
Klinikum der Ludwig Maximilians Universität München Grosshadern, Med Klinik und Poliklinik I, Marchioninistr 15, Munich, Germany
Cardiovasc Res 77:722-31. 2008..Therefore, we analysed in a murine model of experimental myocardial infarction (MI) the influence of PTH treatment on survival, functional parameters, stem cell migration, and expression of vascular endothelial growth factor A (VEGF-A)...
- Exploration of global gene expression changes during the estrous cycle in equine endometriumSimone Gebhardt
Laboratory for Functional Genome Analysis LAFUGA and Chair for Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Munich, Germany
Biol Reprod 87:136. 2012....
- Short-term exposure to low-carbohydrate, high-fat diets induces low bone mineral density and reduces bone formation in ratsMaximilian Bielohuby
Endocrine Research Unit, Medizinische Klinik Innenstadt, Ludwig Maximilians University, Munich, Germany
J Bone Miner Res 25:275-84. 2010..This might indicate a lower rate of mesenchymal stem cells differentiating into osteoblasts, thus explaining reduced bone formation with LC-HF diets...
- Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projectsBernhard Aigner
Institute of Molecular Animal Breeding and Biotechnology, Hackerstrasse 27, Oberschleissheim, Germany
Am J Physiol Endocrinol Metab 294:E232-40. 2008....
- Temporal changes in phosphatidylserine expression and glucose metabolism after myocardial infarction: an in vivo imaging study in miceSebastian Lehner
Department of Nuclear Medicine, Institute of Veterinary Pathology, University of Munich, Munich, Germany
Mol Imaging 11:461-70. 2012..Whereas FDG-PET revealed continuous loss of cell viability after permanent LAD artery occlusion, annexin-PET indicated peak phosphatidylserine expression at day 2, which might be the optimal time point for therapy monitoring...
- HLA-E/human beta2-microglobulin transgenic pigs: protection against xenogeneic human anti-pig natural killer cell cytotoxicityElisabeth H Weiss
Department of Biology II, Anthropology and Human Genetics, LMU Munich, Planegg Martinsried, Germany
Transplantation 87:35-43. 2009....
- Gene expression profiling of bovine peripartal placentomes: detection of molecular pathways potentially involved in the release of foetal membranesDominik Streyl
Clinic for Ruminants with Ambulatory and Herd Health Services, Centre for Clinical Veterinary Medicine, LMU Munich, Oberschleißheim, Germany
Reproduction 143:85-105. 2012..These results are an excellent basis for future studies investigating the molecular basis of retained foetal membranes...
- Functional consequences of IGFBP excess-lessons from transgenic miceEckhard Wolf
Institute of Molecular Animal Breeding and Biotechnology Gene Center, Munich, Germany
Pediatr Nephrol 20:269-78. 2005..Furthermore, analysis of IGFBP expression in growth-selected mouse lines or pedigrees segregating for growth phenotypes will be important to understand the roles of IGFBPs in multigenic growth regulation...
- Induction of oxazolone-mediated features of atopic dermatitis in NOD-scid IL2Rγ(null) mice engrafted with human peripheral blood mononuclear cellsThomas Nolte
Institute of Molecular Animal Breeding and Biotechnology, and Laboratory for Functional Genome Analysis, Gene Center, LMU Munich, 81377 Munich, Germany
Dis Model Mech 6:125-34. 2013....
- Podocyte-specific deletion of integrin-linked kinase results in severe glomerular basement membrane alterations and progressive glomerulosclerosisChiraz El-Aouni
Division of Nephrology, Department of Internal Medicine, University of Michigan, 1570 MSRB II, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0676, USA
J Am Soc Nephrol 17:1334-44. 2006....