Nadja Herbach

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi request reprint Overexpression of a dominant negative GIP receptor in transgenic mice results in disturbed postnatal pancreatic islet and beta-cell development
    Nadja Herbach
    Institute of Veterinary Pathology, Veterinaerstrasse 13, 80539 Munich, Germany
    Regul Pept 125:103-17. 2005
  2. pmc Postnatal development of numbers and mean sizes of pancreatic islets and beta-cells in healthy mice and GIPR(dn) transgenic diabetic mice
    Nadja Herbach
    Institute of Veterinary Pathology, Center for Clinical Veterinary Medicine, LMU Munich, Germany
    PLoS ONE 6:e22814. 2011
  3. doi request reprint Diabetic kidney lesions of GIPRdn transgenic mice: podocyte hypertrophy and thickening of the GBM precede glomerular hypertrophy and glomerulosclerosis
    Nadja Herbach
    Institute of Veterinary Pathology, Veterinaerstr 13, 80539 Munich, Germany
    Am J Physiol Renal Physiol 296:F819-29. 2009
  4. ncbi request reprint Dominant-negative effects of a novel mutated Ins2 allele causes early-onset diabetes and severe beta-cell loss in Munich Ins2C95S mutant mice
    Nadja Herbach
    Institute of Veterinary Pathology, University of Munich, Munich, Germany
    Diabetes 56:1268-76. 2007
  5. ncbi request reprint Diets influence the diabetic phenotype of transgenic mice expressing a dominant negative glucose-dependent insulinotropic polypeptide receptor (GIPRdn)
    Nadja Herbach
    Institute of Veterinary Pathology, Veterinaerstr 13, 80539 Munich, Germany
    Regul Pept 146:260-70. 2008
  6. doi request reprint Erythropoietin administration after myocardial infarction in mice attenuates ischemic cardiomyopathy associated with enhanced homing of bone marrow-derived progenitor cells via the CXCR-4/SDF-1 axis
    Stefan Brunner
    Klinikum Grosshadern, Medical Department I, Munich, Germany
    FASEB J 23:351-61. 2009
  7. doi request reprint Specific transgene expression in mouse pancreatic beta-cells under the control of the porcine insulin promoter
    Marjeta Grzech
    Chair for Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Feodor Lynen Str 25, 81377 Munich, Germany
    Mol Cell Endocrinol 315:219-24. 2010
  8. pmc Permanent neonatal diabetes in INS(C94Y) transgenic pigs
    Simone Renner
    Chair for Molecular Animal Breeding and Biotechnology, Ludwig Maximilian University Munich, Munich, Germany
    Diabetes 62:1505-11. 2013
  9. ncbi request reprint Screening for increased plasma urea levels in a large-scale ENU mouse mutagenesis project reveals kidney disease models
    Bernhard Aigner
    Institute of Molecular Animal Breeding and BiotechnologyInstitute of Molecular Animal Breeding and Biotechnology, Ludwig Maximilians University, Munich, Germany
    Am J Physiol Renal Physiol 292:F1560-7. 2007
  10. doi request reprint The cardioprotective effects of parathyroid hormone are independent of endogenous granulocyte-colony stimulating factor release
    Stefan Brunner
    Department of Internal Medicine I, Ludwig Maximilians University, Campus Grosshadern, Munich, Germany
    Cardiovasc Res 93:330-9. 2012

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Overexpression of a dominant negative GIP receptor in transgenic mice results in disturbed postnatal pancreatic islet and beta-cell development
    Nadja Herbach
    Institute of Veterinary Pathology, Veterinaerstrasse 13, 80539 Munich, Germany
    Regul Pept 125:103-17. 2005
    ..These findings demonstrate in vivo evidence that intact signaling of G-protein coupled receptors is involved in postnatal islet and beta-cell development and neogenesis of the pancreatic islets...
  2. pmc Postnatal development of numbers and mean sizes of pancreatic islets and beta-cells in healthy mice and GIPR(dn) transgenic diabetic mice
    Nadja Herbach
    Institute of Veterinary Pathology, Center for Clinical Veterinary Medicine, LMU Munich, Germany
    PLoS ONE 6:e22814. 2011
    ..GIPR(dn) transgenic mice show a disturbed expansion of the endocrine pancreas, due to perturbed islet neogenesis...
  3. doi request reprint Diabetic kidney lesions of GIPRdn transgenic mice: podocyte hypertrophy and thickening of the GBM precede glomerular hypertrophy and glomerulosclerosis
    Nadja Herbach
    Institute of Veterinary Pathology, Veterinaerstr 13, 80539 Munich, Germany
    Am J Physiol Renal Physiol 296:F819-29. 2009
    ..GIPR(dn) transgenic mice are considered an excellent new tool to study the mechanisms involved in onset and progression of diabetic nephropathy...
  4. ncbi request reprint Dominant-negative effects of a novel mutated Ins2 allele causes early-onset diabetes and severe beta-cell loss in Munich Ins2C95S mutant mice
    Nadja Herbach
    Institute of Veterinary Pathology, University of Munich, Munich, Germany
    Diabetes 56:1268-76. 2007
    ..Thus, Munich Ins2(C95S) mutant mice are considered a valuable model to study the mechanisms of beta-cell dysfunction and death during the development of diabetes...
  5. ncbi request reprint Diets influence the diabetic phenotype of transgenic mice expressing a dominant negative glucose-dependent insulinotropic polypeptide receptor (GIPRdn)
    Nadja Herbach
    Institute of Veterinary Pathology, Veterinaerstr 13, 80539 Munich, Germany
    Regul Pept 146:260-70. 2008
    ..GIPR(dn) transgenic mice develop a severe diabetic phenotype which can be ameliorated by a HF diet, thereby resembling some aspects of the pathophysiology of human type 2 diabetes mellitus...
  6. doi request reprint Erythropoietin administration after myocardial infarction in mice attenuates ischemic cardiomyopathy associated with enhanced homing of bone marrow-derived progenitor cells via the CXCR-4/SDF-1 axis
    Stefan Brunner
    Klinikum Grosshadern, Medical Department I, Munich, Germany
    FASEB J 23:351-61. 2009
    ..However, EPO has no beneficial effects on resident CSCs. Therefore, new treatment regimes using EPO together with other agents may combine complementary beneficial effects preventing ischemic cardiomyopathy...
  7. doi request reprint Specific transgene expression in mouse pancreatic beta-cells under the control of the porcine insulin promoter
    Marjeta Grzech
    Chair for Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Feodor Lynen Str 25, 81377 Munich, Germany
    Mol Cell Endocrinol 315:219-24. 2010
    ..We conclude that the newly designed expression cassette containing 1500bp of the porcine insulin promoter 5' UTR confers robust and specific transgene expression to beta-cells in vitro and in transgenic mice...
  8. pmc Permanent neonatal diabetes in INS(C94Y) transgenic pigs
    Simone Renner
    Chair for Molecular Animal Breeding and Biotechnology, Ludwig Maximilian University Munich, Munich, Germany
    Diabetes 62:1505-11. 2013
    ....
  9. ncbi request reprint Screening for increased plasma urea levels in a large-scale ENU mouse mutagenesis project reveals kidney disease models
    Bernhard Aigner
    Institute of Molecular Animal Breeding and BiotechnologyInstitute of Molecular Animal Breeding and Biotechnology, Ludwig Maximilians University, Munich, Germany
    Am J Physiol Renal Physiol 292:F1560-7. 2007
    ....
  10. doi request reprint The cardioprotective effects of parathyroid hormone are independent of endogenous granulocyte-colony stimulating factor release
    Stefan Brunner
    Department of Internal Medicine I, Ludwig Maximilians University, Campus Grosshadern, Munich, Germany
    Cardiovasc Res 93:330-9. 2012
    ..PTH-related stem cell mobilization was shown to be related to endogenous granulocyte-colony stimulating factor (G-CSF) release. The aim of our study is to determine the role of G-CSF on the cardioprotective effects of PTH...
  11. ncbi request reprint Systemic overexpression of growth hormone (GH) in transgenic FVB/N inbred mice: an optimized model for holistic studies of molecular mechanisms underlying GH-induced kidney pathology
    Dagmar C von Waldthausen
    Institute of Molecular Animal Breeding and Biotechnology and Laboratory for Functional Genome Analysis LAFUGA, Gene Center, LMU Munich, Feodor Lynen Strasse 25, Munich, Germany
    Transgenic Res 17:479-88. 2008
    ..Moreover, genetically defined cbetaa-bGH mice facilitate random mutagenesis screens for modifier genes which influence the effects of chronic GH excess and associated pathological lesions...
  12. pmc Glucose intolerance and reduced proliferation of pancreatic beta-cells in transgenic pigs with impaired glucose-dependent insulinotropic polypeptide function
    Simone Renner
    Chair for Molecular Animal Breeding and Biotechnology and Laboratory for Functional Genome Analysis, Gene Center, Ludwig Maximilians University LMU Munich, Munich, Germany
    Diabetes 59:1228-38. 2010
    ....
  13. doi request reprint Synergy between CD26/DPP-IV inhibition and G-CSF improves cardiac function after acute myocardial infarction
    Marc Michael Zaruba
    Medical Department I, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Cell Stem Cell 4:313-23. 2009
    ..Therefore, we propose pharmacological DPP-IV inhibition and G-CSF-based stem cell mobilization as a therapeutic concept for future stem cell trials after myocardial infarction...
  14. doi request reprint Differential glomerular proteome analysis of two murine nephropathy models at onset of albuminuria
    Andreas Blutke
    Institute of Veterinary Pathology, Ludwig Maximilians Universitaet München, Germany
    Proteomics Clin Appl 5:375-81. 2011
    ..The purpose of the present study was to identify protein biomarker candidates for these glomerular alterations...
  15. ncbi request reprint Growth analysis of the mouse adrenal gland from weaning to adulthood: time- and gender-dependent alterations of cell size and number in the cortical compartment
    Max Bielohuby
    Institute of Molecular Animal Breeding and Biotechnology, Ludwig Maximilians University, Munich, Germany
    Am J Physiol Endocrinol Metab 293:E139-46. 2007
    ..These factors require careful consideration in studies aiming at the functional dissection of genetic and environmental factors affecting adrenal growth and function...
  16. pmc Xenografted islet cell clusters from INSLEA29Y transgenic pigs rescue diabetes and prevent immune rejection in humanized mice
    Nikolai Klymiuk
    Chair for Molecular Animal Breeding and Biotechnology, and Laboratory for Functional Genome Analysis, Gene Center, Ludwig Maximilians Universitat, Munich, Germany
    Diabetes 61:1527-32. 2012
    ..This approach may represent a major step toward the development of a novel strategy for pig-to-human islet transplantation without side effects of systemic immunosuppression...
  17. doi request reprint First inducible transgene expression in porcine large animal models
    Nikolai Klymiuk
    Ludwig Maximilians Universitat Munchen, Munich, Germany
    FASEB J 26:1086-99. 2012
    ..Our strategy revealed the first two examples of inducible transgene expression in pigs. The CAG-TA transgenic pigs generated in this study constitute an interesting basis for future pig models with inducible transgene expression...
  18. ncbi request reprint Betacellulin overexpression in transgenic mice causes disproportionate growth, pulmonary hemorrhage syndrome, and complex eye pathology
    Marlon R Schneider
    Institute of Molecular Animal Breeding and Biotechnology, Gene Center, University of Munich, Germany
    Endocrinology 146:5237-46. 2005
    ..Thus, our model uncovers multiple consequences of BTC overexpression in vivo. These transgenic mice provide a useful model for examining the effects of BTC excess on different organs...
  19. ncbi request reprint Parathyroid hormone treatment after myocardial infarction promotes cardiac repair by enhanced neovascularization and cell survival
    Marc Michael Zaruba
    Klinikum der Ludwig Maximilians Universität München Grosshadern, Med Klinik und Poliklinik I, Marchioninistr 15, Munich, Germany
    Cardiovasc Res 77:722-31. 2008
    ..Therefore, we analysed in a murine model of experimental myocardial infarction (MI) the influence of PTH treatment on survival, functional parameters, stem cell migration, and expression of vascular endothelial growth factor A (VEGF-A)...
  20. doi request reprint Exploration of global gene expression changes during the estrous cycle in equine endometrium
    Simone Gebhardt
    Laboratory for Functional Genome Analysis LAFUGA and Chair for Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Munich, Germany
    Biol Reprod 87:136. 2012
    ....
  21. ncbi request reprint Short-term exposure to low-carbohydrate, high-fat diets induces low bone mineral density and reduces bone formation in rats
    Maximilian Bielohuby
    Endocrine Research Unit, Medizinische Klinik Innenstadt, Ludwig Maximilians University, Munich, Germany
    J Bone Miner Res 25:275-84. 2010
    ..This might indicate a lower rate of mesenchymal stem cells differentiating into osteoblasts, thus explaining reduced bone formation with LC-HF diets...
  22. ncbi request reprint Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects
    Bernhard Aigner
    Institute of Molecular Animal Breeding and Biotechnology, Hackerstrasse 27, Oberschleissheim, Germany
    Am J Physiol Endocrinol Metab 294:E232-40. 2008
    ....
  23. ncbi request reprint Temporal changes in phosphatidylserine expression and glucose metabolism after myocardial infarction: an in vivo imaging study in mice
    Sebastian Lehner
    Department of Nuclear Medicine, Institute of Veterinary Pathology, University of Munich, Munich, Germany
    Mol Imaging 11:461-70. 2012
    ..Whereas FDG-PET revealed continuous loss of cell viability after permanent LAD artery occlusion, annexin-PET indicated peak phosphatidylserine expression at day 2, which might be the optimal time point for therapy monitoring...
  24. doi request reprint HLA-E/human beta2-microglobulin transgenic pigs: protection against xenogeneic human anti-pig natural killer cell cytotoxicity
    Elisabeth H Weiss
    Department of Biology II, Anthropology and Human Genetics, LMU Munich, Planegg Martinsried, Germany
    Transplantation 87:35-43. 2009
    ....
  25. doi request reprint Gene expression profiling of bovine peripartal placentomes: detection of molecular pathways potentially involved in the release of foetal membranes
    Dominik Streyl
    Clinic for Ruminants with Ambulatory and Herd Health Services, Centre for Clinical Veterinary Medicine, LMU Munich, Oberschleißheim, Germany
    Reproduction 143:85-105. 2012
    ..These results are an excellent basis for future studies investigating the molecular basis of retained foetal membranes...
  26. ncbi request reprint Functional consequences of IGFBP excess-lessons from transgenic mice
    Eckhard Wolf
    Institute of Molecular Animal Breeding and Biotechnology Gene Center, Munich, Germany
    Pediatr Nephrol 20:269-78. 2005
    ..Furthermore, analysis of IGFBP expression in growth-selected mouse lines or pedigrees segregating for growth phenotypes will be important to understand the roles of IGFBPs in multigenic growth regulation...
  27. pmc Induction of oxazolone-mediated features of atopic dermatitis in NOD-scid IL2Rγ(null) mice engrafted with human peripheral blood mononuclear cells
    Thomas Nolte
    Institute of Molecular Animal Breeding and Biotechnology, and Laboratory for Functional Genome Analysis, Gene Center, LMU Munich, 81377 Munich, Germany
    Dis Model Mech 6:125-34. 2013
    ....
  28. ncbi request reprint Podocyte-specific deletion of integrin-linked kinase results in severe glomerular basement membrane alterations and progressive glomerulosclerosis
    Chiraz El-Aouni
    Division of Nephrology, Department of Internal Medicine, University of Michigan, 1570 MSRB II, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0676, USA
    J Am Soc Nephrol 17:1334-44. 2006
    ....