Martin Hennenberg

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. pmc Sorafenib targets dysregulated Rho kinase expression and portal hypertension in rats with secondary biliary cirrhosis
    M Hennenberg
    Department of Internal Medicine I, University of Bonn, Germany
    Br J Pharmacol 157:258-70. 2009
  2. doi Hepatic VASP upregulation in rats with secondary biliary cirrhosis by expression in the peribiliary vascular plexus
    Martin Hennenberg
    Department of Internal Medicine I, University of Bonn, Germany
    Microvasc Res 78:235-40. 2009
  3. doi Mechanisms of extrahepatic vasodilation in portal hypertension
    M Hennenberg
    Department of Internal Medicine I, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Gut 57:1300-14. 2008
  4. doi Lack of effect of norfloxacin on hyperdynamic circulation in bile duct-ligated rats despite reduction of endothelial nitric oxide synthase function: result of unchanged vascular Rho-kinase?
    Martin Hennenberg
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Liver Int 29:933-41. 2009
  5. ncbi Vascular dysfunction in human and rat cirrhosis: role of receptor-desensitizing and calcium-sensitizing proteins
    Martin Hennenberg
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Hepatology 45:495-506. 2007
  6. doi Hepatic and HSC-specific sorafenib effects in rats with established secondary biliary cirrhosis
    Martin Hennenberg
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Lab Invest 91:241-51. 2011
  7. ncbi Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase
    Jonel Trebicka
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Hepatology 46:242-53. 2007
  8. ncbi Defective RhoA/Rho-kinase signaling contributes to vascular hypocontractility and vasodilation in cirrhotic rats
    Martin Hennenberg
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Gastroenterology 130:838-54. 2006
  9. doi Role of beta3-adrenoceptors for intrahepatic resistance and portal hypertension in liver cirrhosis
    Jonel Trebicka
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Hepatology 50:1924-35. 2009
  10. doi Treatment of bile duct-ligated rats with the nitric oxide synthase transcription enhancer AVE 9488 ameliorates portal hypertension
    Erwin Biecker
    Department of Internal Medicine I, University Hospital of Bonn, University of Bonn, Bonn, Germany
    Liver Int 28:331-8. 2008

Collaborators

Detail Information

Publications18

  1. pmc Sorafenib targets dysregulated Rho kinase expression and portal hypertension in rats with secondary biliary cirrhosis
    M Hennenberg
    Department of Internal Medicine I, University of Bonn, Germany
    Br J Pharmacol 157:258-70. 2009
    ..As the multikinase inhibitor sorafenib inhibits ERK, we tested the effect of sorafenib on haemodynamics and dysregulated vascular Rho kinase in rats with secondary biliary cirrhosis...
  2. doi Hepatic VASP upregulation in rats with secondary biliary cirrhosis by expression in the peribiliary vascular plexus
    Martin Hennenberg
    Department of Internal Medicine I, University of Bonn, Germany
    Microvasc Res 78:235-40. 2009
    ..Here, we investigated hepatic VASP expression in response to bile duct ligation (BDL) of rats...
  3. doi Mechanisms of extrahepatic vasodilation in portal hypertension
    M Hennenberg
    Department of Internal Medicine I, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Gut 57:1300-14. 2008
    ..The latter phenomenon has been termed "vascular hypocontractility". It is caused by a combination of different mechanisms and factors described in this review...
  4. doi Lack of effect of norfloxacin on hyperdynamic circulation in bile duct-ligated rats despite reduction of endothelial nitric oxide synthase function: result of unchanged vascular Rho-kinase?
    Martin Hennenberg
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Liver Int 29:933-41. 2009
    ..We investigated the haemodynamic and vascular effects of norfloxacin in rats with secondary biliary cirrhosis...
  5. ncbi Vascular dysfunction in human and rat cirrhosis: role of receptor-desensitizing and calcium-sensitizing proteins
    Martin Hennenberg
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Hepatology 45:495-506. 2007
    ..Our data suggest that in cirrhosis-induced vasodilation, the AT1-R is desensitized by GRK-2 and beta-arrestin-2 and that changed patterns of phosphorylated Ca(2+) sensitizing proteins decrease Ca(2+) sensitivity...
  6. doi Hepatic and HSC-specific sorafenib effects in rats with established secondary biliary cirrhosis
    Martin Hennenberg
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Lab Invest 91:241-51. 2011
    ..This leads to the decrease in intrahepatic vascular resistance, but also to liver damage in the dosage we used. Therefore, any translation to portal hypertensive patients who may profit from sorafenib should be done with particular care...
  7. ncbi Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase
    Jonel Trebicka
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Hepatology 46:242-53. 2007
    ..Furthermore, in BDL rats, atorvastatin significantly increased hepatic endothelial nitric oxide synthase (eNOS) mRNA and protein levels, phospho-eNOS, nitrite/nitrate, and the activity of the NO effector protein kinase G (PKG)...
  8. ncbi Defective RhoA/Rho-kinase signaling contributes to vascular hypocontractility and vasodilation in cirrhotic rats
    Martin Hennenberg
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Gastroenterology 130:838-54. 2006
    ..We investigated the role of the RhoA/Rho-kinase pathway in vascular smooth muscle hypocontractility of rats with secondary biliary cirrhosis...
  9. doi Role of beta3-adrenoceptors for intrahepatic resistance and portal hypertension in liver cirrhosis
    Jonel Trebicka
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Hepatology 50:1924-35. 2009
    ..beta(3)-AR agonists decrease intrahepatic resistance and portal pressure in cirrhotic rats...
  10. doi Treatment of bile duct-ligated rats with the nitric oxide synthase transcription enhancer AVE 9488 ameliorates portal hypertension
    Erwin Biecker
    Department of Internal Medicine I, University Hospital of Bonn, University of Bonn, Bonn, Germany
    Liver Int 28:331-8. 2008
    ..Nitric oxide levels are decreased in the cirrhotic liver and increased in the systemic vasculature. We investigated whether the nitric oxide synthase (NOS) transcription enhancer AVE 9488 ameliorates portal hypertension in cirrhotic rats...
  11. doi Hemodynamic effects of urotensin II and its specific receptor antagonist palosuran in cirrhotic rats
    Jonel Trebicka
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Hepatology 47:1264-76. 2008
    ..The U-II-receptor antagonist palosuran might represent a new therapeutic option in liver cirrhosis with portal hypertension...
  12. doi Atorvastatin attenuates hepatic fibrosis in rats after bile duct ligation via decreased turnover of hepatic stellate cells
    Jonel Trebicka
    Department of Internal Medicine I, University of Bonn, Germany
    J Hepatol 53:702-12. 2010
    ..In vitro, HMG-CoA reductase inhibitors (statins) inhibit proliferation and induce apoptosis of myofibroblastic HSC. To investigate the antifibrotic effects of atorvastatin in vivo we used bile duct ligated rats (BDL)...
  13. doi Role of cannabinoid receptors in alcoholic hepatic injury: steatosis and fibrogenesis are increased in CB2 receptor-deficient mice and decreased in CB1 receptor knockouts
    Jonel Trebicka
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Liver Int 31:860-70. 2011
    ..To investigate the differences between CB(1) and CB(2) in the hepatic response to chronic alcohol intake, we examined CB knockout mice (CB(1)(-/-), CB(2)(-/-))...
  14. ncbi Vascular, hemodynamic and renal effects of low-dose losartan in rats with secondary biliary cirrhosis
    Jorg Heller
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Liver Int 25:657-66. 2005
    ..We hypothesized that losartan decreases portal pressure by counteracting the impaired vascular responsive to alpha1-adrenoceptor agonists...
  15. pmc Intrahepatic upregulation of RhoA and Rho-kinase signalling contributes to increased hepatic vascular resistance in rats with secondary biliary cirrhosis
    Q Zhou
    Department of Internal Medicine I, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Gut 55:1296-305. 2006
    ..Activation of the RhoA/Rho-kinase pathway is essential for contraction of vascular smooth muscle. The aim of this study was to investigate RhoA/Rho-kinase mediated regulation of the intrahepatic vascular tone in cirrhotic rats...
  16. doi Vascular hyporesponsiveness to angiotensin II in rats with CCl(4)-induced liver cirrhosis
    M Hennenberg
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Eur J Clin Invest 39:906-13. 2009
    ..In this study, we analysed the interaction of AT(1) receptors with beta-arrestin-2 in the context of vascular hypocontractility in rats with CCl(4)-induced cirrhosis...
  17. ncbi Acute haemodynamic effects of losartan in anaesthetized cirrhotic rats
    J Heller
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Eur J Clin Invest 33:1006-12. 2003
    ..The angiotensin II type 1 receptor antagonist losartan has been suggested as a portal pressure-lowering drug in patients with cirrhosis...
  18. doi Regulation of NK cell trafficking by CD81
    Benjamin Kramer
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Eur J Immunol 39:3447-58. 2009
    ..Thus, our data suggest that the tetraspanin CD81 is importantly involved in the regulation of NK cell recruitment...