Affiliation: University of Freiburg
- Quantitative and semiquantitative evaluation of erythropoietin-induced bone marrow signal changes in lumbar spine MRI in patients with tumor anemiaNadir Ghanem
Department of Diagnostic Radiology, University Hospital Freiburg, Germany
Onkologie 30:303-8. 2007....
- Tumor cells with low proteasome subunit expression predict overall survival in head and neck cancer patientsChann Lagadec
Department of Radiation Oncology, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, CA 90095, USA
BMC Cancer 14:152. 2014..The objective of this study was to investigate if head and neck squamous cell carcinoma (HNSCC) also contain cancer stem cells that can be identified by low 26S proteasome activity and if their presence correlates to clinical outcome...
- The effects of tea extracts on proinflammatory signalingFrank Pajonk
Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1714, USA
BMC Med 4:28. 2006..We investigated the underlying molecular mechanisms and compared effects of tea extracts with the effects of epigallocatechin-gallate, the proposed most-active moiety of green tea...
- Blood hemoglobin level and treatment outcome of early breast cancerMichael Henke
Department of Radiotherapy, Radiological University Clinic, University Freiburg, Germany
Strahlenther Onkol 180:45-51. 2004..To determine whether the blood hemoglobin concentration correlates with the prognosis of patients with early breast cancer and, if so, whether this is restricted to treatment modality...
- CT-based study on potential mediastinal lymph node spread of patients with lung cancer. Contribution to 3-D treatment planning for adjuvant radiotherapy of the mediastinumJoachim Slanina
Department of Radiation Therapy, Radiological University Clinic, Freiburg, Germany
Strahlenther Onkol 178:199-208. 2002..To provide a schematized and graduated CT reference series of the mediastinum showing CT-detectable lymph node areas of lung cancer patients to support 3-D treatment planning and documentation for adjuvant irradiation of the mediastinum...
- Do erythropoietin receptors on cancer cells explain unexpected clinical findings?Michael Henke
Klinik fur Strahlenheilkunde, Universitatsklinikum, Robert Koch Strasse, 3 D 79106, Freiburg, Germany
J Clin Oncol 24:4708-13. 2006..Recent reports suggest that cancer control may worsen if erythropoietin is administered. We investigated whether erythropoietin receptor expression on cancer cells may correlate with this unexpected finding...
- Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: randomised, double-blind, placebo-controlled trialMichael Henke
Abteilung Strahlenheilkunde der Radiologischen Universitätsklinik, Hugstetter Strasse 55, D 79106, Freiburg, Germany
Lancet 362:1255-60. 2003..We investigated whether anaemia correction with epoetin beta could improve outcome of curative radiotherapy among patients with head and neck cancer...
- Palifermin decreases severe oral mucositis of patients undergoing postoperative radiochemotherapy for head and neck cancer: a randomized, placebo-controlled trialMichael Henke
University Clinic Freiburg, Germany
J Clin Oncol 29:2815-20. 2011..Radiochemotherapy of head and neck cancer causes severe mucositis in most patients. We investigated whether palifermin reduces this debilitating sequela...
- Blood hemoglobin level may affect radiosensitivity-preliminary results on acutely reacting normal tissuesM Henke
Abteilung Strahlentherapie, Radiologische Universitatsklinik, Freiburg, Germany
Int J Radiat Oncol Biol Phys 48:339-45. 2000..To evaluate the influence of blood hemoglobin concentration on the radiosensitivity of acutely reacting normal tissues...
- Erythropoietin in radiation oncology - A review. 1st international conference, Freiburg, June 11-12, 1999M Henke
Radiotherapy Department, Radiological University Clinic, Freiburg i Br, Germany
Oncology 58:175-82. 2000..This report gives a summary reviewing the topic...
- Correction of cancer anemia--impact on disease course, prognosis and treatment efficacy, particularly for patients undergoing radiotherapyM Henke
Strahlenheilkunde Radiologische Universitätsklinik, Freiburg i Br
Onkologie 24:450-4. 2001..Given the efficacy of rhEPO to stimulate erythropoiesis and improve quality of life of cancer patients and its potential to enhance radiation's efficacy seem to earn it a firm place at least in the radiooncologist's arsenal...
- [Alteration of radiation-induced hematotoxicity by amifostine (ethyol)]F Momm
Abteilung Strahlentherapie, Radiologische Universitatsklinik, Freiburg
Strahlenther Onkol 175:2-5. 1999..Radiotherapy--even of small volumes--can decrease leukocyte counts. We examined whether the radio-protector amifostine can reduce this hematotoxicity...
- FDG-PET imaging for the staging and follow-up of small cell lung cancerT Schumacher
Division of Nuclear Medicine, Albert Ludwigs University, Medical Center, Freiburg, Germany
Eur J Nucl Med 28:483-8. 2001..Finally, all findings considered suspicious for tumour involvement on the other staging procedures were also detected by FDG-PET. It is concluded that FDG-PET has potential for use as a simplified staging tool for small cell lung cancer...
- Alteration of radiation-induced hematotoxicity by amifostineF Momm
Department of Radiotherapy, University Clinic Freiburg, Freiburg, Germany
Int J Radiat Oncol Biol Phys 51:947-51. 2001..To investigate whether amifostine can reduce radiation hematotoxicity...
- Reirradiation plus EGFR inhibition in locally recurrent and unresectable head and neck cancer: final results from a single institutionD Milanovic
Department of Radiation Oncology, University Medical Center Freiburg, Robert Koch Str 3, 79106, Freiburg, Germany
Strahlenther Onkol 189:842-8. 2013..This retrospective single-institutional study investigates feasibility, toxicity, and outcome of reirradiation (re-RT) combined with EGFR blockade for these patients...
- Impact of [18F]FDG-PET on the primary staging of small-cell lung cancerI Brink
Division of Nuclear Medicine, University Hospital, Freiburg, Germany
Eur J Nucl Med Mol Imaging 31:1614-20. 2004..The purpose of this study was to evaluate the impact of [18F]fluorodeoxy-D-glucose positron emission tomography (FDG-PET) on the primary staging of patients with small-cell lung cancer (SCLC)...
- Epithelial cells in the peripheral blood of patients with cancer of the head and neck: incidence, detection and possible clinical significanceF Pajonk
Department of Radiotherapy, Radiological University Clinic, Hugstetter Strasse 55, 79106, Freiburg i. Brsg, Germany
Radiother Oncol 59:213-7. 2001..Detection of cytokeratin-19-positive cells coincided with local failure, distant metastasis and anemia...
- Moist skin care can diminish acute radiation-induced skin toxicityFelix Momm
Department of Radiation Therapy, Radiologic University Hospital, Freiburg i Br, Germany
Strahlenther Onkol 179:708-12. 2003..There are several methods of managing them. Validity of these methods, however, is not sufficiently studied. We therefore investigated, whether moist skin care with 3% urea lotion will reduce acute radiation skin toxicity...
- Venous thromboembolism and mortality associated with recombinant erythropoietin and darbepoetin administration for the treatment of cancer-associated anemiaCharles L Bennett
VA Chicago Healthcare System, Department of Medicine, Northwestern University Feinberg School of Medicine, and Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois 60611, USA
JAMA 299:914-24. 2008..Although systematic overviews of trials have identified venous thromboembolism (VTE) risks, none have identified mortality risks with ESAs...
- Does radiation prevent 5-fluorouracil-induced colitis in the early phase of radiochemotherapy? A case report and literature reviewHans Christian Rischke
Department of Radiotherapy, University Hospital Freiburg, Germany
Strahlenther Onkol 183:459-63. 2007..A palliative chemotherapy with 5-FU, oxaliplatin, and leucovorin was started. Again, the patient suffered from severe diarrhea and dose reduction was necessary...
- The erythropoietin-receptor pathway modulates survival of cancer cellsFrank Pajonk
Clinical and Experimental Radiation Biology Research Section, Department of Radiation Therapy, Radiological University Clinic, Robert Koch Str 3, 79106 Freiburg i Brsg, Germany
Oncogene 23:8987-91. 2004..As most human tumors express erythropoietin receptor, we advocate a restricted use erythropoietin to patients suffering from erythropoietin-receptor-expressing cancers...
- Religious belief as a coping strategy: an explorative trial in patients irradiated for head-and-neck cancerGerhild Becker
Department of Internal Medicine II, University Clinic, Freiburg, Germany
Strahlenther Onkol 182:270-6. 2006..To explore the role of religious belief in coping with disease symptoms and treatment-related side effects in patients with head-and-neck cancer under radiotherapy...
- Anemia and long-term outcome in adjuvant and neoadjuvant radiochemotherapy of stage II and III rectal adenocarcinoma: the Freiburg experience (1989-2002)Christian Weissenberger
Department of Radiotherapy, University Hospital of Freiburg, 79106 Freiburg, Germany
World J Gastroenterol 12:1849-58. 2006....
- Influence of intravenous amifostine on xerostomia, tumor control, and survival after radiotherapy for head-and- neck cancer: 2-year follow-up of a prospective, randomized, phase III trialTodd H Wasserman
Department of Radiation Oncology, Washington University, St Louis, MO 63110 1046, USA
Int J Radiat Oncol Biol Phys 63:985-90. 2005....
- Erythropoietin in the treatment of cancerMichael Henke
Onkologie 28:181-2. 2005
- Vitiligo at the sites of irradiation in a patient with Hodgkin's diseaseFrank Pajonk
Department of Radiation Therapy, Radiological University Clinic, Freiburg Br, Germany
Strahlenther Onkol 178:159-62. 2002..Current hypotheses discuss autoimmune, autotoxic and neuronal mechanisms. Here we report the case of radiation-induced depigmentation of the skin of a patient with Hodgkin's disease and 25-year history of vitiligo...
- A multinational, randomized phase III trial of iseganan HCl oral solution for reducing the severity of oral mucositis in patients receiving radiotherapy for head-and-neck malignancyAndy Trotti
Radiation Oncology Program, H Lee Moffitt Cancer Center at the University of South Florida, Tampa, FL, USA
Int J Radiat Oncol Biol Phys 58:674-81. 2004..It is hypothesized that infection plays a role in the development of OM. We tested the efficacy of iseganan HCl (iseganan), a synthetic peptide with broad-spectrum antimicrobial activity, for preventing RT-associated OM...
- Erythropoietin receptors on cancer cells: exciting perspectives, difficult to appreciateMichael Henke
Blood 108:1107-8; author reply 1108-9. 2006
- Psychosocial distress and need for psychotherapeutic treatment in cancer patients undergoing radiotherapyKurt Fritzsche
Department for Psychosomatics and Psychotherapy, University Hospital Freiburg, Hauptstr 8, D 79114 Freiburg, Germany
Radiother Oncol 72:183-9. 2004..We, therefore, assessed the degree of psychosocial distress of radio-oncology inpatients and their need for psychotherapeutic interventions...
- Metastatic breast cancer causing gas gangreneFelix Momm
J Pain Symptom Manage 31:385. 2006