J G Hengstler

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. ncbi request reprint Dephosphorylation of p-ERK1/2 in relation to tumor remission after HER-2 and Raf1 blocking therapy in a conditional mouse tumor model
    Carolin K Hausherr
    Department of Gynecology, University of Mainz, Mainz, Germany
    Mol Carcinog 45:302-8. 2006
  2. ncbi request reprint Metallothionein expression in ovarian cancer in relation to histopathological parameters and molecular markers of prognosis
    J G Hengstler
    Institute of Toxicology, University of Mainz, Mainz, Germany
    Int J Cancer 95:121-7. 2001
  3. ncbi request reprint Contribution of c-erbB-2 and topoisomerase IIalpha to chemoresistance in ovarian cancer
    J G Hengstler
    Institute of Toxicology, University of Mainz, Germany
    Cancer Res 59:3206-14. 1999
  4. ncbi request reprint Cryopreserved primary hepatocytes as a constantly available in vitro model for the evaluation of human and animal drug metabolism and enzyme induction
    J G Hengstler
    Institute of Toxicology, Mainz, Germany
    Drug Metab Rev 32:81-118. 2000
  5. ncbi request reprint Cultures with cryopreserved hepatocytes: applicability for studies of enzyme induction
    J G Hengstler
    Institute of Toxicology, Mainz, Germany
    Chem Biol Interact 125:51-73. 2000
  6. ncbi request reprint Challenging dogma: thresholds for genotoxic carcinogens? The case of vinyl acetate
    J G Hengstler
    Institute of Toxicology, University of Mainz, D 55131 Mainz, Germany
    Annu Rev Pharmacol Toxicol 43:485-520. 2003
  7. ncbi request reprint Occupational exposure to heavy metals: DNA damage induction and DNA repair inhibition prove co-exposures to cadmium, cobalt and lead as more dangerous than hitherto expected
    Jan G Hengstler
    Institute of Toxicology, Obere Zahlbacher Str 67, 55131 Mainz, Germany
    Carcinogenesis 24:63-73. 2003
  8. ncbi request reprint Permissive and suppressive effects of dexamethasone on enzyme induction in hepatocyte co-cultures
    M Ringel
    Institute of Toxicology, Obere Zahlbacher Str 67, D 55131 Mainz, Germany
    Xenobiotica 32:653-66. 2002
  9. ncbi request reprint Differential modulation of CYP2E1 activity by cAMP-dependent protein kinase upon Ser129 replacement
    B Oesch-Bartlomowicz
    Institute of Toxicology, University of Mainz, Germany
    Exp Cell Res 242:294-302. 1998
  10. doi request reprint Long-term outcome prediction by clinicopathological risk classification algorithms in node-negative breast cancer--comparison between Adjuvant!, St Gallen, and a novel risk algorithm used in the prospective randomized Node-Negative-Breast Cancer-3 (NNBC-3
    M Schmidt
    Department of Obstetrics and Gynecology, Johannes Gutenberg University, Mainz, Germany
    Ann Oncol 20:258-64. 2009

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Dephosphorylation of p-ERK1/2 in relation to tumor remission after HER-2 and Raf1 blocking therapy in a conditional mouse tumor model
    Carolin K Hausherr
    Department of Gynecology, University of Mainz, Mainz, Germany
    Mol Carcinog 45:302-8. 2006
    ....
  2. ncbi request reprint Metallothionein expression in ovarian cancer in relation to histopathological parameters and molecular markers of prognosis
    J G Hengstler
    Institute of Toxicology, University of Mainz, Mainz, Germany
    Int J Cancer 95:121-7. 2001
    ..High expression of both sulfhydryl factors may identify a subgroup of low-grade carcinomas with an increased risk of progression...
  3. ncbi request reprint Contribution of c-erbB-2 and topoisomerase IIalpha to chemoresistance in ovarian cancer
    J G Hengstler
    Institute of Toxicology, University of Mainz, Germany
    Cancer Res 59:3206-14. 1999
    ..The data suggest that topoisomerase IIlalpha, which correlates with c-erbB-2 expression, contributes to the resistance of c-erbB-2-overexpressing carcinomas...
  4. ncbi request reprint Cryopreserved primary hepatocytes as a constantly available in vitro model for the evaluation of human and animal drug metabolism and enzyme induction
    J G Hengstler
    Institute of Toxicology, Mainz, Germany
    Drug Metab Rev 32:81-118. 2000
    ..Systems with cryopreserved hepatocyte cultures that could be applied for studies of enzyme induction are already in a state allowing practical application, but may be further optimized...
  5. ncbi request reprint Cultures with cryopreserved hepatocytes: applicability for studies of enzyme induction
    J G Hengstler
    Institute of Toxicology, Mainz, Germany
    Chem Biol Interact 125:51-73. 2000
    ....
  6. ncbi request reprint Challenging dogma: thresholds for genotoxic carcinogens? The case of vinyl acetate
    J G Hengstler
    Institute of Toxicology, University of Mainz, D 55131 Mainz, Germany
    Annu Rev Pharmacol Toxicol 43:485-520. 2003
    ..The example of vinyl acetate underlines the importance of toxicological research that unequivocally identifies genotoxic carcinogens acting through a threshold process...
  7. ncbi request reprint Occupational exposure to heavy metals: DNA damage induction and DNA repair inhibition prove co-exposures to cadmium, cobalt and lead as more dangerous than hitherto expected
    Jan G Hengstler
    Institute of Toxicology, Obere Zahlbacher Str 67, 55131 Mainz, Germany
    Carcinogenesis 24:63-73. 2003
    ..Co-exposure may cause genotoxic effects, even if the concentrations of individual heavy metals do not exceed TRK-values...
  8. ncbi request reprint Permissive and suppressive effects of dexamethasone on enzyme induction in hepatocyte co-cultures
    M Ringel
    Institute of Toxicology, Obere Zahlbacher Str 67, D 55131 Mainz, Germany
    Xenobiotica 32:653-66. 2002
    ..However, a large interlaboratory variation is known. Our study provides evidence that differences in glucocorticoid concentration in the culture medium contribute to this variation...
  9. ncbi request reprint Differential modulation of CYP2E1 activity by cAMP-dependent protein kinase upon Ser129 replacement
    B Oesch-Bartlomowicz
    Institute of Toxicology, University of Mainz, Germany
    Exp Cell Res 242:294-302. 1998
    ....
  10. doi request reprint Long-term outcome prediction by clinicopathological risk classification algorithms in node-negative breast cancer--comparison between Adjuvant!, St Gallen, and a novel risk algorithm used in the prospective randomized Node-Negative-Breast Cancer-3 (NNBC-3
    M Schmidt
    Department of Obstetrics and Gynecology, Johannes Gutenberg University, Mainz, Germany
    Ann Oncol 20:258-64. 2009
    ..We have developed a novel risk classification algorithm and compared its prognostic utility to the Web-based tool Adjuvant! and to the St Gallen risk classification...
  11. ncbi request reprint Hepatocytes cultured in alginate microspheres: an optimized technique to study enzyme induction
    M Ringel
    Institute of Toxicology, University of Mainz, Germany
    Toxicology 206:153-67. 2005
    ..In conclusion, we optimized a technique for encapsulation of hepatocytes in alginate microspheres that allows identification of enzyme induction with an improved sensitivity compared to existing systems...
  12. doi request reprint Role of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor type 1 (PAI-1) for prognosis in endometrial cancer
    E Steiner
    Department of Gynecology, University of Mainz, Mainz, Germany
    Gynecol Oncol 108:569-76. 2008
    ..Here, we studied a possible association between cytosolic uPA and PA-1 concentrations in tumor tissue with prognosis in patients with endometrial cancer...
  13. ncbi request reprint Diabetes mellitus is a multivariate independent prognostic factor in endometrial carcinoma: a clinicopathologic study on 313 patients
    E Steiner
    Department of Obsterics and Gynaecology, Johannes Gutenberg University, Mainz, Germany
    Eur J Gynaecol Oncol 28:95-7. 2007
    ..The aim of this study was to analyse the influence of diabetes mellitus as a prognostic factor for overall survival in endometrial cancer...
  14. ncbi request reprint Mutation analysis of the cationic trypsinogen gene in patients with pancreatic cancer
    J G Hengstler
    Institute of Toxicology, University of Mainz, Germany
    Anticancer Res 20:2967-74. 2000
    ..In contrast to most oncogenes or tumor suppressor genes the cationic trypsinogen gene (3rd exon) does not contain mutational hot spots...
  15. ncbi request reprint Metabolic detoxification: implications for thresholds
    F Oesch
    Institute of Toxicology, University of Mainz, Germany
    Toxicol Pathol 28:382-7. 2000
    ..As pointed out above, absolute thresholds probably do not exist in chemical carcinogenesis...
  16. ncbi request reprint Multivariate independent prognostic factors in endometrial carcinoma: a clinicopathologic study in 181 patients: 10 years experience at the Department of Obstetrics and Gynecology of the Mainz University
    E Steiner
    Department of Obstetrics and Gynecology, Johannes Gutenberg University, Mainz, Germany
    Int J Gynecol Cancer 13:197-203. 2003
    ....
  17. ncbi request reprint New prognostic and predictive factors in breast cancer
    M Schmidt
    Department of Obstetrics and Gynecology, Johannes Gutenberg University, Mainz, Germany
    Minerva Ginecol 62:599-611. 2010
    ..This should allow us to quantify the risk of progression in each individual patient and tailor treatment accordingly, leading to a more personalized treatment recommendation...
  18. ncbi request reprint c-erbB-2 expression in small-cell lung cancer is associated with poor prognosis
    P Micke
    III Medical Department, Pulmonary Division, Mainz University Hospital, Mainz, Germany
    Int J Cancer 92:474-9. 2001
    ..Since c-erbB-2 is a therapeutical target in other types of cancer, further studies to identify the role of c-erbB-2 in SCLC are clearly warranted...
  19. ncbi request reprint cAMP-dependent phosphorylation of CYP2B1 as a functional switch for cyclophosphamide activation and its hormonal control in vitro and in vivo
    B Oesch-Bartlomowicz
    Institute of Toxicology, University of Mainz, Mainz, Germany
    Int J Cancer 94:733-42. 2001
    ..In conclusion, a successful therapy with CPA, helped by forced expression of CYP2B1 in tumor cells (as recently proposed) will, in addition, be profoundly modified by its phosphorylation status...
  20. ncbi request reprint Sequestration of biological reactive intermediates by trapping as covalent enzyme-intermediate complex
    F Oesch
    Institute of Toxicology, University of Mainz, Germany
    Adv Exp Med Biol 500:577-86. 2001
    ..Above 100 microM, the genotoxic effect of STO in the mEH-expressing cell line parallels the one in the parental cell line...
  21. ncbi request reprint [Deliberate self-poisoning with paracetamol (acetaminophen): an analysis from 1995 to 2002]
    M A von Mach
    Klinische Toxikologie und Beratungsstelle bei Vergiftungen, II Medizinische Klinik und Poliklinik, Klinikum der Johannes Gutenberg Universität Mainz, Germany
    Dtsch Med Wochenschr 128:15-9. 2003
    ..In the present study the cases of intoxications consulting our Poison Center should be analysed illustrating recent results and trends...
  22. ncbi request reprint Angiogenesis and fibroblast proliferation precede formation of recurrent tumors after radiation therapy in nude mice
    J Hast
    Department of Radiology, Johannes Gutenberg University Mainz, Germany
    Anticancer Res 22:677-88. 2002
    ....
  23. ncbi request reprint Lack of mutagenic and co-mutagenic effects of magnetic fields during magnetic resonance imaging
    W G Schreiber
    Department of Radiology, Johannes Gutenberg University, Mainz, Germany
    J Magn Reson Imaging 14:779-88. 2001
    ..No co-mutagenic effect of any magnetic field combination was observed. In conclusion, magnetic fields used during clinical magnetic resonance imaging (MRI) were neither mutagenic nor co-mutagenic...
  24. ncbi request reprint [Cryotherapy of malignant tumors: studies with MRI in an animal experiment and comparison with morphological changes]
    B Romaneehsen
    Klinik und Poliklinik für Radiologie, Johannes Gutenberg Universitat Mainz
    Rofo 173:632-8. 2001
    ....
  25. ncbi request reprint [Possible mutagenic effects of magnetic fields]
    E M Teichmann
    Klinik für Radiologie und Strahlentherapie
    Rofo 172:934-9. 2000
    ..To assess the potential mutagenic effect of static magnetic fields of 1.5 T and 7 T, gradient fields and high frequency magnetic fields...
  26. ncbi request reprint ERBB2-mediated transcriptional up-regulation of the alpha5beta1 integrin fibronectin receptor promotes tumor cell survival under adverse conditions
    Christian Spangenberg
    Children s Hospital, University of Mainz, Obere Zahlbacher Strasse 63, 55131 Mainz, Germany
    Cancer Res 66:3715-25. 2006
    ..This new insight could be the basis for additional approaches complementing current cancer therapy...
  27. ncbi request reprint Loss of tumor suppressor protein PTEN during renal carcinogenesis
    Walburgis Brenner
    Department of Urology, University of Mainz, Mainz, Germany
    Int J Cancer 99:53-7. 2002
    ..We conclude that PTEN expression and PTEN membrane localization are lost during early renal cell carcinogenesis and may therefore be a valuable RCC tumor marker...
  28. doi request reprint Conditional transgenic mouse models: from the basics to genome-wide sets of knockouts and current studies of tissue regeneration
    Ernesto Bockamp
    Johannes Gutenberg Universitat Mainz, Institute of Toxicology Mouse Genetics, Obere Zahlbacher Str 67, 55131, Mainz, Germany
    Regen Med 3:217-35. 2008
    ..Finally, the possibilities of conditional expression systems for investigating gene function in tissue regeneration will be illustrated by examples for neurodegenerative disease, liver regeneration and wound healing of the skin...
  29. doi request reprint Isolation of fibroblasts for coating of meshes for reconstructive surgery: differences between mesh types
    Christine E Skala
    Mainz University Hospital, Department of Obstetrics and Gynecology, D 55131 Mainz, Germany
    Regen Med 4:197-204. 2009
    ..Therefore, we aimed to establish a technique that allows isolation and propagation of fibroblasts from vaginal biopsies. Using these cells we tested the applicability of several clinically applied meshes for fibroblast coating...
  30. ncbi request reprint Premature senescence is a primary fail-safe mechanism of ERBB2-driven tumorigenesis in breast carcinoma cells
    Tatjana M Trost
    Children s Hospital, University of Mainz, Obere Zahlbacher Strasse 63, 55131 Mainz, Germany
    Cancer Res 65:840-9. 2005
    ..We propose a multistep model for the process of malignant transformation by ERBB2 wherein secondary lesions either target P21 or downstream effectors of senescence to bypass this primary fail-safe mechanism...
  31. doi request reprint Ep-CAM RNA expression predicts metastasis-free survival in three cohorts of untreated node-negative breast cancer
    Marcus Schmidt
    Department of Obstetrics and Gynecology, University Medical Center of the Johannes Gutenberg University, Langenbeckstr 1, 55131, Mainz, Germany
    Breast Cancer Res Treat 125:637-46. 2011
    ..030, HR = 1.8). In conclusion, Ep-CAM RNA expression is associated with poor MFS in three cohorts of untreated node-negative breast cancer...
  32. doi request reprint Prognostic effect of epithelial cell adhesion molecule overexpression in untreated node-negative breast cancer
    Marcus Schmidt
    Department of Obstetrics and Gynecology, Johannes Gutenberg University, Leipzig, Germany
    Clin Cancer Res 14:5849-55. 2008
    ..We examined Ep-CAM expression in 402 consecutive node-negative breast cancer patients with long-term follow-up not treated in the adjuvant setting...
  33. ncbi request reprint Protein kinase C eta is associated with progression of renal cell carcinoma (RCC)
    Walburgis Brenner
    Department of Urology, University of Mainz, Langenbeckstr 1, 55131 Mainz, Germany
    Anticancer Res 23:4001-6. 2003
    ..The expression of all eleven PKC-isoforms in clear cell RCCs (ccRCC) and in the corresponding normal renal tissue was quantified. A possible association of PKC-isoforms with histopathological parameters was examined...
  34. ncbi request reprint Regulation of beta1 integrin expression by PKCepsilon in renal cancer cells
    Walburgis Brenner
    Department of Urology, University of Mainz, D 55131 Mainz, Germany
    Int J Oncol 25:1157-63. 2004
    ..These findings provide a conceptual basis for treatment of renal cell carcinoma by interfering with tumor cell proliferation...
  35. ncbi request reprint Switching off HER-2/neu in a tetracycline-controlled mouse tumor model leads to apoptosis and tumor-size-dependent remission
    Ilka B Schiffer
    Institute of Toxicology, Johannes Gutenberg University of Mainz, Obere Zahlbacherstrasse 67, 55131 Mainz, Germany
    Cancer Res 63:7221-31. 2003
    ..Tumor remission was dependent on the volume of the tumors before down-regulation of HER-2/neu...
  36. ncbi request reprint No influence of magnetic fields on cell cycle progression using conditions relevant for patients during MRI
    Ilka B Schiffer
    Institute of Toxicology, University of Mainz, Mainz, Germany
    Bioelectromagnetics 24:241-50. 2003
    ..Care was taken to control secondary parameters of influence, such as vibration by the MR scanner or temperature to avoid false positive results...
  37. ncbi request reprint Experiences of a poison center network with renal insufficiency in acetaminophen overdose: an analysis of 17 cases
    M A von Mach
    Division of Clinical Toxicology and Poison Center, II Medical Department, University of Mainz, Mainz, Germany
    Clin Toxicol (Phila) 43:31-7. 2005
    ..Presently, a larger number of patients with renal insufficiency associated with acetaminophen overdose should be analyzed using a multicenter approach...
  38. ncbi request reprint Age-related and tissue-specific accumulation of oxidative DNA base damage in 7,8-dihydro-8-oxoguanine-DNA glycosylase (Ogg1) deficient mice
    M Osterod
    Institute of Pharmacy and Institute of Toxicology, University of Mainz, D 55099 Mainz, Germany
    Carcinogenesis 22:1459-63. 2001
    ....
  39. ncbi request reprint Size of pancreatic islets of Langerhans: a key parameter for viability after cryopreservation
    M A von Mach
    Second Medical Department, University of Mainz, Germany
    Acta Diabetol 40:123-9. 2003
    ..For different techniques of removal of the cryoprotectant, no significant influence on viabilities was found. We conclude that large islets represented a highly susceptible population concerning damage due to cryopreservation...
  40. doi request reprint The humoral immune system has a key prognostic impact in node-negative breast cancer
    Marcus Schmidt
    Department of Obstetrics and Gynecology, Medical School, Johannes Gutenberg University, Mainz, Germany
    Cancer Res 68:5405-13. 2008
    ..83; 95% CI, 0.7-0.97). Thus, we could show in three cohorts of untreated, node-negative breast cancer patients that the humoral immune system plays a pivotal role in metastasis-free survival of carcinomas of the breast...
  41. pmc Role of the progesterone receptor for paclitaxel resistance in primary breast cancer
    M Schmidt
    Department of Obstetrics and Gynecology, Medical School, University of Mainz, Mainz, Germany
    Br J Cancer 96:241-7. 2007
    ..Thus, PR status should be considered as a possible factor of influence when designing new trials and chemotherapy protocols...
  42. ncbi request reprint Quantitative analysis of VEGF-isoforms in head and neck squamous cell carcinoma cell lines: relation to xenotransplantability and tumour progression in mice
    Konstantinos Vlachtsis
    Department of Otorhinolaryngology, University Hospital, School of Medicine, Mainz, Germany
    Oncol Rep 9:1133-8. 2002
    ..We conclude that the ratio between the VEGF-subtypes during tumour implantation and growth is a prerequisite for progression and hypothesise an individual and different response of each tumour cell line to VEGF...
  43. doi request reprint Coordinates in the universe of node-negative breast cancer revisited
    Marcus Schmidt
    Department of Obstetrics and Gynecology, Johannes Gutenberg University, Medical School, Mainz, Germany
    Cancer Res 69:2695-8. 2009
    ..Dissecting tumors according to these three major biological axes will allow further understanding of biological processes relevant for tumor progression in patients with node-negative breast cancer...
  44. ncbi request reprint A global DNA repair mechanism involving the Cockayne syndrome B (CSB) gene product can prevent the in vivo accumulation of endogenous oxidative DNA base damage
    Marcel Osterod
    Institute of Pharmacy, University of Mainz, D 55099 Mainz, Germany
    Oncogene 21:8232-9. 2002
    ..The data indicate a role for Csb in the removal of 8-oxoG from the overall genome that is independent of both Ogg1-mediated base excision repair and regular transcription...
  45. ncbi request reprint Molecular modes of action of artesunate in tumor cell lines
    Thomas Efferth
    Center for Molecular Biology of the University of Heidelberg ZMBH, Heidelberg, Germany
    Mol Pharmacol 64:382-94. 2003
    ..ART acts via p53-dependent and- independent pathways in isogenic p53+/+ p21WAF1/CIP1+/+, p53-/- p21WAF1/CIP1+/+, and p53+/+ p21WAF1/CIP1-/- colon carcinoma cells...
  46. ncbi request reprint Carcinogenicity categorization of chemicals-new aspects to be considered in a European perspective
    Hermann M Bolt
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Ardeystr 67, D 44139 Dortmund, Germany
    Toxicol Lett 151:29-41. 2004
    ..This should be changed, as the philosophy of separation of a strictly sequential "hazard assessment" and "risk assessment" appears out-of-date...
  47. doi request reprint Cadmium, cobalt and lead cause stress response, cell cycle deregulation and increased steroid as well as xenobiotic metabolism in primary normal human bronchial epithelial cells which is coordinated by at least nine transcription factors
    Felix Glahn
    Institute of Environmental Toxicology, Martin Luther University, Halle Wittenberg, Halle Saale, Germany
    Arch Toxicol 82:513-24. 2008
    ..This study gives an overview of the most responsive genes...
  48. doi request reprint Prediction of paclitaxel resistance in breast cancer: is CYP1B1*3 a new factor of influence?
    Mathias Gehrmann
    Siemens Medical Solutions Diagnostics GmbH, Leverkusen, Germany
    Pharmacogenomics 9:969-74. 2008
    ..In the future, studies with SNP chips and studies on the transcriptome, proteome and metabolome level should be performed in order to identify signatures differentiating between paclitaxel-sensitive and -resistant patients...
  49. doi request reprint Developments in industrial and occupational toxicology: REACH, toxicogenomics, mycotoxins, lead, asbestos, boron, bitumen, deletions polymorphisms and SNP interactions: meeting report of the 16th EUROTOX training and discussion session
    Gisela H Degen
    Leibniz Research Centre for Working Environment and Human Factors IfADo, Institut fur Arbeitsphysiologie an der Universitat Dortmund, Ardeystrasse 67, 44139 Dortmund, Germany
    Arch Toxicol 82:483-7. 2008
  50. ncbi request reprint Perfluorinated compounds (PFC) hit the headlines : meeting report on a satellite symposium of the annual meeting of the German Society of Toxicology
    Peter H Roos
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Ardeystr 67, 44139 Dortmund, Germany
    Arch Toxicol 82:57-9. 2008
  51. ncbi request reprint Heavy metal status and oxidative stress in diesel engine tuning workers of central Indian population
    Sivanesan Saravana Devi
    Environmental Biotechnology Division, National Environmental Engineering Research Institute, Nagpur, India
    J Occup Environ Med 49:1228-34. 2007
    ..To assess the oxidative stress induced due to heavy metal exposure. Exposed populations are selected from an engine tuning station and control from the same area with no occupational exposure...
  52. ncbi request reprint Could treatment with neohepatocytes benefit patients with decompensated chronic liver disease?
    James A Hutchinson
    Am J Hematol 82:947-8. 2007
  53. ncbi request reprint SPOC1, a novel PHD-finger protein: association with residual disease and survival in ovarian cancer
    Gerrit Mohrmann
    Institute of Human Genetics, University of Erlangen Nuremberg, Erlangen, Germany
    Int J Cancer 116:547-54. 2005
    ..In conclusion, SPOC1 is a novel PHD-finger protein showing strong expression in spermatogonia and ovarian cancer cells. SPOC1 overexpression was associated with unresectable carcinomas and shorter survival in ovarian cancer...
  54. ncbi request reprint Differentiation of in vitro-modified human peripheral blood monocytes into hepatocyte-like and pancreatic islet-like cells
    Maren Ruhnke
    Department of General and Thoracic Surgery, University Hospital Schleswig Holstein, Kiel, Germany
    Gastroenterology 128:1774-86. 2005
    ..We evaluated the differentiation potential of human peripheral blood monocytes into hepatocyte-like and pancreatic islet-like cells...
  55. ncbi request reprint Benzene and its methyl-derivatives: derivation of maximum exposure levels in automobiles
    Thomas Schupp
    Elastogran, Department for Ecology and Product Safety, Lemförde, Germany
    Toxicol Lett 160:93-104. 2006
    ..A systematic toxicological evaluation of the risk associated with benzene exposure in cars seems to be necessary...
  56. ncbi request reprint Enzyme induction in cryopreserved human hepatocyte cultures
    Sabine Kafert-Kasting
    Cytonet GmbH and Co, KG Hannover Branch, Feodor Lynen Strasse 21, D 30625 Hannover, Germany
    Toxicology 220:117-25. 2006
    ..4-fold in non-frozen hepatocytes, respectively. In conclusion, human hepatocytes cryopreserved on collagen gels show a clear induction of CYP3A4 by rifampicin, although the basal activities are reduced compared to non-frozen cells...
  57. ncbi request reprint Expression patterns and novel splicing variants of glutathione-S-transferase isoenzymes of human lung and hepatocyte cell lines
    Mario Bauer
    Department of Human Exposure Research and Epidemiology, UFZ Centre for Environmental Research Leipzig Halle, Permoserstrasse 15, 04318 Leipzig, Germany
    Cell Tissue Res 324:423-32. 2006
    ..The most common genetic polymorphisms are present among the cell lines and have to be considered for in vitro stimulation approaches in a combinatory pattern...
  58. ncbi request reprint Tumor cell specific toxicity of Inula helenium extracts
    David C Dorn
    Laboratory of Developmental Hematopoiesis, Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Phytother Res 20:970-80. 2006
    ....
  59. pmc Functional integration of hepatocytes derived from human mesenchymal stem cells into mouse livers
    Ines Aurich
    1st Department of Medicine, Heinrich Damerow Strasse 1, Martin Luther University of Halle Wittenberg, D 06120 Halle Saale, Germany
    Gut 56:405-15. 2007
    ..Hence, novel cell sources are required to deliver hepatocytes of adequate quality for clinical use. Mesenchymal stem cells (MSCs) from human bone marrow may have the potential to differentiate into hepatocytes in vitro and in vivo...
  60. ncbi request reprint CYP2D6 increases toxicity of the designer drug 4-methylthioamphetamine (4-MTA)
    Helena Carmo
    REQUIMTE, Toxicology Department, Faculty of Pharmacy, University of Porto, Rua Anibal Cunha 164, 4099 030 Porto, Portugal
    Toxicology 229:236-44. 2007
    ..In contrast to CYP2D6, the CYP3A4 isoenzyme did not enhance 4-MTA toxicity. In conclusion, our results suggest that CYP2D6 rapid metabolizers may be more susceptible to 4-MTA toxicity than CYP2D6 poor metabolizers...
  61. ncbi request reprint Mathematical modelling of liver regeneration after intoxication with CCl(4)
    Stefan Höhme
    Interdisciplinary Centre for Bioinformatics, University of Leipzig, Hartelstr 16 18, D 04107 Leipzig, Germany
    Chem Biol Interact 168:74-93. 2007
    ....
  62. ncbi request reprint Maximum exposure levels for xylene, formaldehyde and acetaldehyde in cars
    Thomas Schupp
    Elastogran, Department for Ecology and Product Safety, P O Box 1140, D 49440 Lemförde, Germany
    Toxicology 206:461-70. 2005
    ..With respect to STELIAs and extrapolated concentrations at 65 degrees C (14.7, 1.47 and 1.68 mg/m(3), for xylene, formaldehyde and acetaldehyde, respectively), however, a reduction of the concentration of formaldehyde may be necessary...