Cristoph Helmstaedter

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. ncbi request reprint Memory outcome after selective amygdalohippocampectomy in patients with temporal lobe epilepsy: one-year follow-up
    Ulrike Gleissner
    University Hospital of Epileptology, Bonn, Germany
    Epilepsia 45:960-2. 2004
  2. doi request reprint Disentangling the relationship between epilepsy and its behavioral comorbidities - the need for prospective studies in new-onset epilepsies
    C Helmstaedter
    University Clinic of Epileptology, Bonn, Germany Electronic address
    Epilepsy Behav 31:43-7. 2014
  3. doi request reprint [Assessing activities of daily living in patients with epilepsy]
    C Helmstaedter
    Klinik für Epileptologie, Universitatsklinikum Bonn
    Fortschr Neurol Psychiatr 81:452-8. 2013
  4. doi request reprint Genetic variation in dopaminergic activity is associated with the risk for psychiatric side effects of levetiracetam
    Christoph Helmstaedter
    Department of Epileptology, University of Bonn, Bonn, Germany
    Epilepsia 54:36-44. 2013
  5. doi request reprint Multifactorial etiology of interictal behavior in frontal and temporal lobe epilepsy
    Christoph Helmstaedter
    Department of Epileptology, University of Bonn, Bonn, Germany
    Epilepsia 53:1765-73. 2012
  6. doi request reprint Neuropsychological outcome after selective amygdalohippocampectomy: subtemporal versus transsylvian approach
    Björn von Rhein
    Department of Epileptology, University of Bonn Medical Centre, Bonn, Germany
    J Neurol Neurosurg Psychiatry 83:887-93. 2012
  7. ncbi request reprint Effects of chronic epilepsy on declarative memory systems
    C Helmstaedter
    Department of Epileptology, University of Bonn, 53105 Bonn, Germany
    Prog Brain Res 135:439-53. 2002
  8. doi request reprint Chronic temporal lobe epilepsy: a neurodevelopmental or progressively dementing disease?
    C Helmstaedter
    Neuropsychology, Department of Epileptology, University Hospital of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Brain 132:2822-30. 2009
  9. ncbi request reprint Memory alterations during acute high-intensity vagus nerve stimulation
    C Helmstaedter
    Department of Epileptology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Epilepsy Res 47:37-42. 2001
  10. doi request reprint Positive and negative psychotropic effects of levetiracetam
    C Helmstaedter
    Department of Epileptology, University Hospital of Bonn, Bonn, Germany
    Epilepsy Behav 13:535-41. 2008

Collaborators

Detail Information

Publications88

  1. ncbi request reprint Memory outcome after selective amygdalohippocampectomy in patients with temporal lobe epilepsy: one-year follow-up
    Ulrike Gleissner
    University Hospital of Epileptology, Bonn, Germany
    Epilepsia 45:960-2. 2004
    ..We supposed that the observed postoperative impairments might have reflected acute effects of surgery. Therefore we evaluated in the present study whether a recovery can be found 1 year after surgery...
  2. doi request reprint Disentangling the relationship between epilepsy and its behavioral comorbidities - the need for prospective studies in new-onset epilepsies
    C Helmstaedter
    University Clinic of Epileptology, Bonn, Germany Electronic address
    Epilepsy Behav 31:43-7. 2014
    ....
  3. doi request reprint [Assessing activities of daily living in patients with epilepsy]
    C Helmstaedter
    Klinik für Epileptologie, Universitatsklinikum Bonn
    Fortschr Neurol Psychiatr 81:452-8. 2013
    ..The study at hand examined whether a questionnaire assessing the activities of daily living provides additional diagnostic information...
  4. doi request reprint Genetic variation in dopaminergic activity is associated with the risk for psychiatric side effects of levetiracetam
    Christoph Helmstaedter
    Department of Epileptology, University of Bonn, Bonn, Germany
    Epilepsia 54:36-44. 2013
    ..Recent behavioral research indicates that personality traits may predispose to these side effects. To assess the genetic basis of the adverse psychotropic profile of LEV, a candidate gene-based two-stage association study was conducted...
  5. doi request reprint Multifactorial etiology of interictal behavior in frontal and temporal lobe epilepsy
    Christoph Helmstaedter
    Department of Epileptology, University of Bonn, Bonn, Germany
    Epilepsia 53:1765-73. 2012
    ....
  6. doi request reprint Neuropsychological outcome after selective amygdalohippocampectomy: subtemporal versus transsylvian approach
    Björn von Rhein
    Department of Epileptology, University of Bonn Medical Centre, Bonn, Germany
    J Neurol Neurosurg Psychiatry 83:887-93. 2012
    ....
  7. ncbi request reprint Effects of chronic epilepsy on declarative memory systems
    C Helmstaedter
    Department of Epileptology, University of Bonn, 53105 Bonn, Germany
    Prog Brain Res 135:439-53. 2002
    ..Thus early and efficient seizure control and the prevention of any cerebral damage from the beginning of epilepsy are demanded...
  8. doi request reprint Chronic temporal lobe epilepsy: a neurodevelopmental or progressively dementing disease?
    C Helmstaedter
    Neuropsychology, Department of Epileptology, University Hospital of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Brain 132:2822-30. 2009
    ..The findings suggest that increased attention is to be paid to the time of epilepsy onset and thereafter. Early control of epilepsy is demanded to counteract developmental hindrance and damage at a younger age...
  9. ncbi request reprint Memory alterations during acute high-intensity vagus nerve stimulation
    C Helmstaedter
    Department of Epileptology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Epilepsy Res 47:37-42. 2001
    ..However, since the effectors and the direction of the cognitive effects of VNS seem to depend strongly on stimulation conditions, we recommend future experimental research covering a larger range of stimulation conditions...
  10. doi request reprint Positive and negative psychotropic effects of levetiracetam
    C Helmstaedter
    Department of Epileptology, University Hospital of Bonn, Bonn, Germany
    Epilepsy Behav 13:535-41. 2008
    ..The goals of this study were to observe behavioral changes in patients receiving levetiracetam (LEV), a newer antiepileptic drug (AED), and to answer the question of whether LEV exerts a specific effect on impulse control and aggression...
  11. ncbi request reprint The effects of cognitive rehabilitation on memory outcome after temporal lobe epilepsy surgery
    Cristoph Helmstaedter
    University Clinic of Epileptology Bonn, Bonn, Germany
    Epilepsy Behav 12:402-9. 2008
    ..The aim of this study was to investigate the short-term effects of cognitive rehabilitation on memory outcome after temporal lobe epilepsy surgery...
  12. ncbi request reprint Shift-back of right into left hemisphere language dominance after control of epileptic seizures: evidence for epilepsy driven functional cerebral organization
    C Helmstaedter
    Department of Epileptology, University of Bonn, Sigmund Freud Str 25, 53127 Bonn, Germany
    Epilepsy Res 70:257-62. 2006
    ..However, further research in larger groups of atypically dominant patients is required to identify the conditions under which atypical dominance becomes hardwired and when not...
  13. ncbi request reprint Chronic epilepsy and cognition: a longitudinal study in temporal lobe epilepsy
    Christoph Helmstaedter
    University Clinic of Epileptology, Bonn, Germany
    Ann Neurol 54:425-32. 2003
    ..Surgery, particularly if unsuccessful, accelerates this decline. However, memory decline may be stopped and even reversed if seizures are fully controlled...
  14. ncbi request reprint The impact of sex and language dominance on material-specific memory before and after left temporal lobe surgery
    C Helmstaedter
    University Clinic of Epileptology Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Brain 127:1518-25. 2004
    ..For clinical practice, it is important to note that incomplete right hemisphere and bilateral language dominance do not protect against verbal memory loss after left-sided temporal lobe surgery...
  15. ncbi request reprint Memory and epilepsy: characteristics, course, and influence of drugs and surgery
    C Helmstaedter
    Universitat Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Curr Opin Neurol 14:211-6. 2001
    ..New input in the field has resulted from improved imaging techniques, sophisticated experimental study designs, more selective surgical approaches, and new antiepileptic drugs...
  16. doi request reprint Unique and shared validity of the "Wechsler logical memory test", the "California verbal learning test", and the "verbal learning and memory test" in patients with epilepsy
    Christoph Helmstaedter
    Department of Epileptology, University of Bonn, Bonn, Germany
    Epilepsy Res 87:203-12. 2009
    ..This study was set-up to evaluate the construct validity of three verbal memory tests in epilepsy patients...
  17. doi request reprint Quality of life in patients with partial-onset seizures under adjunctive therapy with zonisamide: results from a prospective non-interventional surveillance study
    Christoph Helmstaedter
    University Clinic of Epileptology, University of Bonn, Bonn, Germany
    Epileptic Disord 13:263-76. 2011
    ..QOL improvement was predicted by baseline score, seizure outcome, and overall drug load, and is thus more likely a result of enhanced seizure control, rather than an intrinsic psychotropic effect of zonisamide...
  18. doi request reprint The cognitive consequence of resecting nonlesional tissues in epilepsy surgery--results from MRI- and histopathology-negative patients with temporal lobe epilepsy
    Christoph Helmstaedter
    Department of Epileptology, University of Bonn Medical Centre, Bonn, Germany
    Epilepsia 52:1402-8. 2011
    ....
  19. ncbi request reprint Neuropsychological aspects of epilepsy surgery
    Christoph Helmstaedter
    University Clinic of Epileptology Bonn, 53105 Bonn, Germany
    Epilepsy Behav 5:S45-55. 2004
    ..From a neuropsychological point of view, early recognition of pharmacoresistance is important along with early and complete seizure control with maximal sparing of functional tissues...
  20. doi request reprint Hippocampal resection length and memory outcome in selective epilepsy surgery
    Christoph Helmstaedter
    Department of Epileptology, University Hospital Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    J Neurol Neurosurg Psychiatry 82:1375-81. 2011
    ..Therefore, a sub-analysis of the larger SFB/TR3/A1 multicentre randomised trial on seizure outcome and mesial resection length in temporal lobe surgery was performed...
  21. doi request reprint Introduction and first validation of EpiTrack Junior, a screening tool for the assessment of cognitive side effects of antiepileptic medication on attention and executive functions in children and adolescents with epilepsy
    C Helmstaedter
    Department of Epileptology, University of Bonn, Bonn, Germany
    Epilepsy Behav 19:55-64. 2010
    ..Herewith we introduce the junior version of EpiTrack, a 12- to 15-minute screening test for monitoring the cognitive effects of antiepileptic drug treatment in children and adolescents aged 6 to 18...
  22. doi request reprint Cognitive outcome of antiepileptic treatment with levetiracetam versus carbamazepine monotherapy: a non-interventional surveillance trial
    Christoph Helmstaedter
    University Clinic of Epileptology, University of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Epilepsy Behav 18:74-80. 2010
    ..3, deterioration with CBZ OR=3.4). The findings suggest a mild but definitely superior cognitive outcome with LEV as opposed to CBZ monotherapy...
  23. ncbi request reprint Behavioral markers for self- and other-attribution of memory: a study in patients with temporal lobe epilepsy and healthy volunteers
    C Helmstaedter
    University Clinic of Epileptology Bonn Sigmund Freud Street 25, 53105, Bonn, Germany
    Epilepsy Res 41:235-43. 2000
    ..Regarding this we investigated in patients with temporal lobe epilepsy (TLE) whether there is evidence that persons mistake other cognitive performances for memory due to subjective memory theories...
  24. doi request reprint [Neuropsychology in epilepsy]
    C Helmstaedter
    Universitätsklinik für Epileptologie, Sigmund Freud Str 25, 53105 Bonn
    Fortschr Neurol Psychiatr 77:639-45. 2009
    ..Finally, the cognitive risks and benefits of epilepsy surgery and the advantages of selective surgery will be addressed. The consequences for the neuropsychological assessment are discussed in part two of this review...
  25. ncbi request reprint Clinical and neuropsychological characteristics of pediatric epilepsy patients with atypical language dominance
    U Gleissner
    Department of Epileptology, University of Bonn, Sigmund Freud Str 25, 53105, Bonn, Germany
    Epilepsy Behav 4:746-52. 2003
    ..It is recommended that the possibility of a language shift in the presurgical workup of pediatric patients be considered, particularly if a left-hemispheric epileptic focus is suspected...
  26. ncbi request reprint EpiTrack: tracking cognitive side effects of medication on attention and executive functions in patients with epilepsy
    M T Lutz
    Department of Epileptology, University of Bonn, Bonn, Germany
    Epilepsy Behav 7:708-14. 2005
    ..Test selection was based on recent studies on the effects of topiramate on cognition and retrospective inspection of results from patients with antiepileptic drug (AED) side effects...
  27. ncbi request reprint Hippocampal function and visual object processing in temporal lobe epilepsy
    M Vannucci
    Department of Epileptology, University of Bonn, Germany
    Neuroreport 14:1489-92. 2003
    ..This finding suggests that the hippocampus proper contributes to the semantic processing of visual objects and may help to explain visual memory deficits in TLE...
  28. ncbi request reprint Pre- and postoperative verbal memory in pediatric patients with temporal lobe epilepsy
    U Gleissner
    Department of Epileptology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Epilepsy Res 51:287-96. 2002
    ..Declines after left-sided temporal resections seem to be reversible at least for part of the children, perhaps due to the greater plasticity of the immature brain...
  29. doi request reprint [Neuropsychology in epilepsy]
    J A Witt
    Universitätsklinik für Epileptologie, Bonn
    Fortschr Neurol Psychiatr 77:691-8. 2009
    ....
  30. ncbi request reprint Synaptic plasticity in the human dentate gyrus
    H Beck
    Department of Epileptology, University of Bonn Medical Center, D 53105 Bonn, Germany
    J Neurosci 20:7080-6. 2000
    ..Because both verbal memory processes and synaptic plasticity are impaired by a hippocampal seizure focus, we suggest that impaired synaptic plasticity may contribute to deficient declarative memory in human temporal lobe epilepsy...
  31. pmc Lesional mesial temporal lobe epilepsy and limited resections: prognostic factors and outcome
    H Clusmann
    Department of Neurosurgery, University Bonn Medical Centre, 53105, Germany
    J Neurol Neurosurg Psychiatry 75:1589-96. 2004
    ..To evaluate the influence of clinical, investigational, surgical, and histopathological factors on postoperative seizure relief in patients with mesial temporal lobe epilepsy (MTLE) due to lesions other than ammonshornsclerosis (AHS)...
  32. ncbi request reprint Efficacy and cognitive side effects of tiagabine and topiramate in patients with epilepsy
    N Fritz
    Department of Epileptology, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Epilepsy Behav 6:373-81. 2005
    ..Therefore, we performed a comparative open randomized trial with TPM and TGB as add-on therapy, with particular consideration of cognition, mood, and health-related quality of life (HRQOL)...
  33. ncbi request reprint Neuropsychological outcome after chemotherapy for primary CNS lymphoma: a prospective study
    K Fliessbach
    Department of Neurology, University Hospital Bonn, Germany
    Neurology 64:1184-8. 2005
    ..The impact of high-dose methotrexate (MTX)-based chemotherapy alone on cognition and quality of life (QOL) is controversial...
  34. ncbi request reprint Greater functional recovery after temporal lobe epilepsy surgery in children
    U Gleissner
    Department of Epileptology, University of Bonn, Bonn, Germany
    Brain 128:2822-9. 2005
    ..Our neuropsychological data provide evidence of greater plasticity and compensational capacity in childhood. The results can be taken as a strong argument for early surgical intervention...
  35. ncbi request reprint [A new questionnaire for recognizing cognitive problems in children and adolescents]
    U Gleissner
    Epileptologie, Universitätsklinik Bonn
    Nervenarzt 77:449-65. 2006
    ..The purpose of this study was to present a parental questionnaire (KOPKIJ) that assesses neuropsychologic problems in children and adolescents between 6 and 16 years of age...
  36. ncbi request reprint The validity of the Child Behavior Checklist for children with epilepsy
    U Gleissner
    Department of Epileptology, University of Bonn, Bonn, Germany
    Epilepsy Behav 12:276-80. 2008
    ..Elevated scores on the ambiguous items thus probably reflect real behavioral problems and are not due to confusion with seizure semiology. The results support the CBCL as a valid assessment tool in children with epilepsy...
  37. pmc Collateral brain damage, a potential source of cognitive impairment after selective surgery for control of mesial temporal lobe epilepsy
    C Helmstaedter
    University Clinic of Epileptology, Bonn, Germany
    J Neurol Neurosurg Psychiatry 75:323-6. 2004
    ....
  38. pmc Behavioural disorders in children with epilepsy: early improvement after surgery
    M Lendt
    University Hospital of Epileptology, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    J Neurol Neurosurg Psychiatry 69:739-44. 2000
    ..However, the early postoperative development of behavioural problems has not been systematically evaluated...
  39. ncbi request reprint Human temporal lobe potentials in verbal learning and memory processes
    C E Elger
    Department of Epileptology, University of Bonn, Germany
    Neuropsychologia 35:657-67. 1997
    ..Thus, intracranial recordings indicated that different electrophysiological responses in different temporal lobe structures were linked to memory scores from specific neuropsychological tests...
  40. pmc Combined systemic and intraventricular chemotherapy in primary CNS lymphoma: a pilot study
    U Schlegel
    Department of Neurology, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    J Neurol Neurosurg Psychiatry 71:118-22. 2001
    ..In conclusion, primary chemotherapy based on high dose MTX and ara-C is highly efficient in PCNSL. Toxicity is manageable in patients younger than 70 years...
  41. ncbi request reprint Depression in patients with temporal lobe epilepsy is related to mesial temporal sclerosis
    A Quiske
    University Hospital of Epileptology, Bonn, Germany
    Epilepsy Res 39:121-5. 2000
    ..Depression was a good indicator for MTS but not vice versa. Hence, MTS can be discussed as a predisposing factor for the development of mood disorders in focal epilepsy...
  42. ncbi request reprint Pre- and postoperative neuropsychological profiles in children and adolescents with temporal lobe epilepsy
    M Lendt
    University Hospital of Epileptology, Bonn, Germany
    Epilepsia 40:1543-50. 1999
    ..To evaluate the neuropsychological performance of children before and after temporal lobe resection (TLR)...
  43. ncbi request reprint Ecological validity of list-learning tests and self-reported memory in healthy individuals and those with temporal lobe epilepsy
    C Helmstaedter
    University Hospital of Epileptology, Bonn, Germany
    J Clin Exp Neuropsychol 20:365-75. 1998
    ..They also indicate that incidentally acquired knowledge might be differentially represented in patients with a memory disorder and healthy persons...
  44. ncbi request reprint Long-term seizure outcome and antiepileptic drug treatment in surgically treated temporal lobe epilepsy patients: a controlled study
    C G Bien
    Department of Epileptology, University of Bonn, Bonn, Germany
    Epilepsia 42:1416-21. 2001
    ..To evaluate the long-term impact of surgical treatment on seizure outcome and antiepileptic drug (AED) use in patients with pharmacoresistant temporal lobe epilepsy (TLE)...
  45. ncbi request reprint The performance-complaint relationship in patients with epilepsy: a matter of daily demands?
    U Gleissner
    University Hospital of Epileptology, Bonn, Germany
    Epilepsy Res 32:401-9. 1998
    ..Cognitive demands thus appeared not as a modulating factor that weakens the relationship between test deficits and subjective complaints in patients with TLE...
  46. pmc Right hippocampal contribution to visual memory: a presurgical and postsurgical study in patients with temporal lobe epilepsy
    U Gleissner
    Klinik für Epileptologie, Bonn, Germany
    J Neurol Neurosurg Psychiatry 65:665-9. 1998
    ..The present study investigates in patients with right temporal lobe epilepsy (RTLE), both preoperatively and postoperatively, the role of the right hippocampus for visual memory, visuoconstruction, and spatial visualisation...
  47. ncbi request reprint Neuropsychological consequences of epilepsy surgery in frontal lobe epilepsy
    C Helmstaedter
    University Hospital of Epileptology, Bonn, Germany
    Neuropsychologia 36:681-9. 1998
    ..Finally, a release of functions associated to frontal areas not affected by surgery is suggested, when seizures are successfully controlled by surgery...
  48. ncbi request reprint Neuropsychological consequences of epilepsy surgery in frontal lobe epilepsy
    C Helmstaedter
    University Hospital of Epileptology, Bonn, Germany
    Neuropsychologia 36:333-41. 1998
    ..Finally, a release of functions associated with frontal areas not affected by surgery is suggested, when seizures are successfully controlled by surgery...
  49. pmc Verbal novelty detection within the human hippocampus proper
    T Grunwald
    Department of Epileptology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Proc Natl Acad Sci U S A 95:3193-7. 1998
    ..Because sclerosis of the hippocampus proper selectively reduced event-related potentials to new but not old verbal stimuli, it can be concluded that the human hippocampus proper contributes to verbal novelty detection...
  50. ncbi request reprint Relational verbal memory processing in patients with temporal lobe epilepsy
    C Helmstaedter
    University Hospital of Epileptology, Bonn
    Cortex 33:667-78. 1997
    ....
  51. ncbi request reprint Limbic encephalitis not associated with neoplasm as a cause of temporal lobe epilepsy
    C G Bien
    Departments of Epileptology, University of Bonn, Germany
    Neurology 55:1823-8. 2000
    ..To describe four patients with temporal lobe epilepsy with limbic encephalitis unrelated to neoplasm...
  52. ncbi request reprint The localizing value of ictal consciousness and its constituent functions: a video-EEG study in patients with focal epilepsy
    S Lux
    Department of Epileptology, University of Bonn, Germany
    Brain 125:2691-8. 2002
    ..The localizing value of patterns of impairment of constituent functions is superior to that of 'consciousness' as a whole...
  53. ncbi request reprint Global brain dysmyelination with above-average verbal skills in 18q- syndrome with a 17 Mb terminal deletion
    C Netzer
    Institute of Human Genetics, Rheinische Friedrich Wilhelms University, Bonn, Germany
    Acta Neurol Scand 114:133-8. 2006
    ....
  54. ncbi request reprint Sexuality in male psychiatric inpatients. a descriptive comparison of psychiatric patients, patients with epilepsy and healthy volunteers
    J Westheide
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Pharmacopsychiatry 40:183-90. 2007
    ..Therefore, the aim of the following study was to examine sexual behaviour and sexual dysfunction in a large sample of psychiatric patients...
  55. ncbi request reprint Diagnostic delay in psychogenic nonepileptic seizures
    M Reuber
    Department of Epileptology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Neurology 58:493-5. 2002
    ..Other patient factors did not explain the great variability of the time to diagnosis, suggesting that physician factors contributed to delays...
  56. ncbi request reprint Memory outcome after selective amygdalohippocampectomy: a study in 140 patients with temporal lobe epilepsy
    Ulrike Gleissner
    University Hospital of Epileptology, Bonn, Germany
    Epilepsia 43:87-95. 2002
    ..The results of previous studies, however, are equivocal in this regard. This study evaluated memory after SAH in a large sample of patients with mesial temporal lobe epilepsy...
  57. ncbi request reprint Memory reorganization in adult brain: observations in three patients with temporal lobe epilepsy
    Ulrike Gleissner
    University Hospital of Epileptology, Sigmund Frued Str 25, 53105, Bonn, Germany
    Epilepsy Res 48:229-34. 2002
    ..All patients showed a marked recovery of nonverbal memory after left-sided surgery. Results are discussed with respect to memory transfer and plasticity for memory functions in the adult brain...
  58. doi request reprint Neuropsychological results in pediatric patients with epilepsy surgery in the parietal cortex
    Ulrike Gleissner
    Department of Epileptology, University of Bonn, Bonn, Germany
    Epilepsia 49:700-4. 2008
    ..Postoperative improvements were found in behavior and attention; other cognitive functions were unchanged. All in all, this preliminary study indicated a satisfactory neuropsychological outcome in pediatric patients with PLE...
  59. ncbi request reprint Cognitive outcome of status epilepticus in adults
    Christoph Helmstaedter
    University Clinic of Epileptology, Department of Epileptology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Epilepsia 48:85-90. 2007
    ..Reviewing the literature the cognitive condition in patients with status epilepticus varies with the type of epilepsy, the etiology of epilepsy, severity of the status, and the age of the patient...
  60. doi request reprint Sensory gating in epilepsy - effects of the lateralization of hippocampal sclerosis
    Timm Rosburg
    Department of Epileptology, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Clin Neurophysiol 119:1310-9. 2008
    ..The role of the hippocampus in sensory gating is unresolved as yet. The current study was conducted in order to examine the effects of hippocampal lesions on the function of auditory sensory gating...
  61. doi request reprint Hippocampal response to visual objects is related to visual memory functioning
    Manila Vannucci
    Department of Epileptology, Bonn University Medical Center, Bonn, Germany
    Neuroreport 19:965-8. 2008
    ..These findings suggest that neural responses to visual objects within the hippocampus proper are directly linked to visual memory performance...
  62. pmc Enhancement of neocortical-medial temporal EEG correlations during non-REM sleep
    Nikolai Axmacher
    Department of Epileptology, University of Bonn, 53105 Bonn, Germany
    Neural Plast 2008:563028. 2008
    ....
  63. ncbi request reprint Ictal neuropsychological findings in focal nonconvulsive status epilepticus
    Thomas Profitlich
    Department of Epileptology, University of Bonn, Bonn, Germany
    Epilepsy Behav 12:269-75. 2008
    ..This study was intended to describe the neuropsychological phenomenology of focal nonconvulsive status epilepticus (NCSE)...
  64. ncbi request reprint Depressed mood and memory impairment in temporal lobe epilepsy as a function of focus lateralization and localization
    Christoph Helmstaedter
    Department of Epileptology, University of Bonn, Bonn, Germany
    Epilepsy Behav 5:696-701. 2004
    ..Memory disorders and depressed mood are prominent psychological symptoms of temporal lobe epilepsies (TLEs). We examined the interaction of depressive mood and memory as a function of focus localization...
  65. ncbi request reprint Long-term memory impairment in patients with focal epilepsy
    Christian Hoppe
    Department of Epileptology, University of Bonn Medical Centre, Bonn, Germany
    Epilepsia 48:26-9. 2007
    ..Preliminary findings indicate that postsurgical training improves memory deficits and encourage further research...
  66. ncbi request reprint Differential effects of temporal pole resection with amygdalohippocampectomy versus selective amygdalohippocampectomy on material-specific memory in patients with mesial temporal lobe epilepsy
    Christoph Helmstaedter
    Department of Epileptology, University of Bonn, Germany
    Epilepsia 49:88-97. 2008
    ....
  67. ncbi request reprint Outcome in psychogenic nonepileptic seizures: 1 to 10-year follow-up in 164 patients
    Markus Reuber
    Department of Neurology, Sheffield Teaching Hospitals NHS Trust, Sheffield, United Kingdom
    Ann Neurol 53:305-11. 2003
    ..Clinical and personality factors can be used to provide an individualized prognosis. By generating a patient-specific profile, they show particular maladaptive traits or tendencies that can identify goals for psychological therapy...
  68. ncbi request reprint Cognitive performance and magnetic resonance imaging findings after high-dose systemic and intraventricular chemotherapy for primary central nervous system lymphoma
    Klaus Fliessbach
    Department of Neurology, University of Bonn, Bonn, Germany
    Arch Neurol 60:563-8. 2003
    ..Treatment protocols without radiotherapy have been implemented to avoid this; however, little detailed neuropsychologic and neuroradiologic data exist to assess the frequency of long-term treatment sequelae in this patient group...
  69. ncbi request reprint Significant improvement in frontal lobe associated neuropsychological functions after withdrawal of topiramate in epilepsy patients
    Edgar Kockelmann
    Department of Epileptology, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Epilepsy Res 54:171-8. 2003
    ..In this study, we investigated changes in frontal lobe associated cognitive measures after TPM withdrawal in epilepsy patients hospitalized for presurgical evaluation...
  70. ncbi request reprint Rhinal-hippocampal EEG coherence is reduced during human sleep
    Juergen Fell
    Department of Epileptology, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Eur J Neurosci 18:1711-6. 2003
    ..The decrease of rhinal-hippocampal EEG coherence from waking state towards sleep may yield an electrophysiological explanation for the sleep-related deficiency of declarative memory...
  71. ncbi request reprint Cognitive profile of topiramate as compared with lamotrigine in epilepsy patients on antiepileptic drug polytherapy: relationships to blood serum levels and comedication
    Edgar Kockelmann
    Department of Epileptology, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Epilepsy Behav 5:716-21. 2004
    ..This retrospective study was conducted to identify cognitive domains affected by topiramate (TPM), and to evaluate the role of blood serum levels of TPM and comedication in the etiology of TPM-induced cognitive impairment...
  72. ncbi request reprint Neuropsychological outcome after selective amygdalohippocampectomy with transsylvian versus transcortical approach: a randomized prospective clinical trial of surgery for temporal lobe epilepsy
    Martin T Lutz
    University Clinic of Epileptology, Bonn, Germany
    Epilepsia 45:809-16. 2004
    ..In SAH, the mesial structures can be approached by different routes, the transsylvian approach and the transcortical approach. Advantages or disadvantages with respect to postoperative cognitive outcome are still a matter of debate...
  73. ncbi request reprint Persistent severe amnesia due to seizure recurrence after unilateral temporal lobectomy
    Thomas Dietl
    Department of Epileptology, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Epilepsy Behav 5:394-400. 2004
    ..In the other patient, repeated conventional MRI revealed no structural abnormalities in the contralateral temporal lobe...
  74. ncbi request reprint Depression and anxiety before and after temporal lobe epilepsy surgery
    Markus Reuber
    University Hospital of Epileptology, Sigmund Freud Str 25, 53105 Bonn, Germany
    Seizure 13:129-35. 2004
    ..To examine the course of depression and anxiety in patients with temporal lobe epilepsy (TLE) treated with epilepsy surgery (and anticonvulsant drugs) or medical means alone...
  75. ncbi request reprint Are there physical risk factors for psychogenic non-epileptic seizures in patients with epilepsy?
    Markus Reuber
    Academic Unit of Neurology, Division of Genomic Medicine, University of Sheffield, Royal Hallanshire Hospital, Glossop Road, Sheffield S10 2JF, UK
    Seizure 12:561-7. 2003
    ..We examine whether these or other physical factors affect the risk of PNES in patients with epilepsy in a controlled study...
  76. ncbi request reprint Prognostic factors and outcome after different types of resection for temporal lobe epilepsy
    Hans Clusmann
    Department of Neurosurgery, University Clinic Bonn, Germany
    J Neurosurg 97:1131-41. 2002
    ..It is unknown whether different resection strategies for temporal lobe epilepsy (TLE) produce alterations in seizure control or neuropsychological performance...
  77. ncbi request reprint Rhinal-hippocampal connectivity determines memory formation during sleep
    Juergen Fell
    Department of Epileptology, University of Bonn, Bonn, Germany
    Brain 129:108-14. 2006
    ..This suggests that rhinal-hippocampal connectivity is a key factor in determining declarative memory formation...
  78. ncbi request reprint Surgical treatment for refractory temporal lobe epilepsy in the elderly: seizure outcome and neuropsychological sequels compared with a younger cohort
    Athanasios Grivas
    Department of Neurosurgery, University Bonn Medical Center, Bonn, Germany
    Epilepsia 47:1364-72. 2006
    ..We intend to delineate clinical and surgical factors influencing outcome in patients older than 50 years at operation and to compare the results with those of a younger patient cohort...
  79. pmc Distinct regional atrophy in the corpus callosum of patients with temporal lobe epilepsy
    Bernd Weber
    Department of Epileptology, University of Bonn, Germany
    Brain 130:3149-54. 2007
    ..These findings may reflect non-specific as well as specific effects of temporal lobe epilepsy on CC development and interhemispheric connectivity...
  80. ncbi request reprint Correlation between EEG rhythms during sleep: surface versus mediotemporal EEG
    Annkathrin Poepel
    Department of Epileptology, University of Bonn, Bonn, Germany
    Neuroreport 18:837-40. 2007
    ..In contrast, we found that within the hippocampus delta/theta power alternated in parallel with fast oscillations above 16 Hz during non-rapid-eye-movement sleep (positive correlations)...
  81. ncbi request reprint Human neocortical and hippocampal near-DC shifts are interconnected
    Juergen Fell
    Department of Epileptology, University of Bonn, D 53105 Bonn, Germany
    Hippocampus 17:413-9. 2007
    ..The finding that neocortical and hippocampal near-DC shifts are interconnected may open new perspectives for the prediction and control of mediotemporal lobe seizures...
  82. ncbi request reprint Cognitive outcomes in patients with chronic temporal lobe epilepsy
    Christoph Helmstaedter
    Department of Epileptology, University of Bonn, Germany
    Epilepsia 47:96-8. 2006
    ..With regard to treatment-associated factors, prevention of additional brain dysfunction/damage and successful seizure control are important...
  83. ncbi request reprint Amelioration of water maze performance deficits by topiramate applied during pilocarpine-induced status epilepticus is negatively dose-dependent
    Christian Frisch
    Department of Epileptology, University of Bonn Medical Center, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Epilepsy Res 73:173-80. 2007
    ..The present results indicate a negative dose-dependency of memory-saving effects of TPM applied during status epilepticus apparently dissociated from hippocampal neuroprotection...
  84. ncbi request reprint Chronic epilepsy and cognition
    Christian E Elger
    Department of Epileptology, Bonn University Hospital, Bonn, Germany
    Lancet Neurol 3:663-72. 2004
    ....
  85. ncbi request reprint Interaction of cognitive aging and memory deficits related to epilepsy surgery
    Christoph Helmstaedter
    Department of Epileptology, University of Bonn, Bonn, Germany
    Ann Neurol 52:89-94. 2002
    ..The results support earlier and tailored epilepsy surgery and suggest that memory prognosis in older age should be considered if more extensive temporal resections would be inevitable...
  86. ncbi request reprint Hippocampus proper distinguishes between identified and unidentified real-life visual objects: an intracranial ERP study
    Manila Vannucci
    Department of Epileptology, Bonn University Medical Center, Germany
    Neurosci Lett 401:165-70. 2006
    ..These findings demonstrate that the hippocampus proper contributes to the identification of visual objects discriminating from the very early between identified and unidentified meaningful visual objects...
  87. ncbi request reprint Postsurgical outcome in pediatric patients with epilepsy: a comparison of patients with intellectual disabilities, subaverage intelligence, and average-range intelligence
    Ulrike Gleissner
    Department of Epileptology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Epilepsia 47:406-14. 2006
    ..Several studies in adult patients have indicated that IQ alone is not a good predictor of postoperative cognitive and seizure outcome. Our study evaluated this subject in children and adolescents...
  88. ncbi request reprint Face and facial expression memory in temporal lobe epilepsy patients: preliminary results
    Sonja Glogau
    Department of Epileptology, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Epilepsy Behav 5:106-12. 2004
    ..Results are discussed according to functional reorganization, memory strategies, perception performance, naming problems, and group characteristics...