Sabine Hellwig

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. ncbi request reprint [¹⁸F]FDG-PET is superior to [¹²³I]IBZM-SPECT for the differential diagnosis of parkinsonism
    Sabine Hellwig
    Department of Neurology, University of Freiburg, Germany
    Neurology 79:1314-22. 2012
  2. doi request reprint Neural correlates of cognitive dysfunction in Lewy body diseases and tauopathies: combined assessment with FDG-PET and the CERAD test battery
    Sabine Hellwig
    Department of Neurology, University Hospital Freiburg, Freiburg, Germany Department of Psychiatry, University Hospital Freiburg, Freiburg, Germany Electronic address
    Brain Lang 127:307-14. 2013
  3. doi request reprint Cerebellar volume is linked to cognitive function in temporal lobe epilepsy: a quantitative MRI study
    Sabine Hellwig
    Department of Psychiatry and Psychotherapy, University Hospital Freiburg, Freiburg, Germany
    Epilepsy Behav 28:156-62. 2013
  4. pmc Reelin together with ApoER2 regulates interneuron migration in the olfactory bulb
    Sabine Hellwig
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Freiburg, Germany
    PLoS ONE 7:e50646. 2012
  5. ncbi request reprint Negative amyloid PET imaging in a patient with probable Alzheimer's disease
    Sabine Hellwig
    Department of Psychiatry and Psychotherapy, University Hospital Freiburg, Freiburg, Germany
    Clin Nucl Med 36:1120-1. 2011
  6. doi request reprint Alzheimer's disease camouflaged by histrionic personality disorder
    Sabine Hellwig
    Department of Psychiatry and Psychotherapy, University Hospital Freiburg, Freiburg, Germany
    Neurocase 18:75-9. 2012
  7. doi request reprint Psychiatric comorbidity in patients with pharmacoresistant focal epilepsy and psychiatric outcome after epilepsy surgery
    Sabine Hellwig
    Department of Psychiatry and Psychotherapy, University Hospital Freiburg, Freiburg, Germany
    Epilepsy Behav 23:272-9. 2012
  8. doi request reprint 123I-iodobenzamide SPECT is not an independent predictor of dopaminergic responsiveness in patients with suspected atypical parkinsonian syndromes
    Sabine Hellwig
    Department of Neurology, University Hospital Freiburg, Freiburg, Germany
    J Nucl Med 54:2081-6. 2013
  9. doi request reprint Assessment of striatal dopamine D2/D3 receptor availability with PET and 18F-desmethoxyfallypride: comparison of imaging protocols suited for clinical routine
    Florian Amtage
    Department of Neurology, University Hospital Freiburg, Freiburg, Germany
    J Nucl Med 53:1558-64. 2012
  10. doi request reprint Syndrome-specific patterns of regional cerebral glucose metabolism in posterior cortical atrophy in comparison to dementia with lewy bodies and Alzheimer's disease-a [f-18]-fdg pet study
    Timo S Spehl
    Department of Nuclear Medicine, Freiburg, Germany
    J Neuroimaging 25:281-8. 2015

Detail Information

Publications19

  1. ncbi request reprint [¹⁸F]FDG-PET is superior to [¹²³I]IBZM-SPECT for the differential diagnosis of parkinsonism
    Sabine Hellwig
    Department of Neurology, University of Freiburg, Germany
    Neurology 79:1314-22. 2012
    ....
  2. doi request reprint Neural correlates of cognitive dysfunction in Lewy body diseases and tauopathies: combined assessment with FDG-PET and the CERAD test battery
    Sabine Hellwig
    Department of Neurology, University Hospital Freiburg, Freiburg, Germany Department of Psychiatry, University Hospital Freiburg, Freiburg, Germany Electronic address
    Brain Lang 127:307-14. 2013
    ..In line with disease-specific patterns of regional glucose metabolism, tauopathies and LBD show distinct cognitive profiles, which may assist clinical differentiation. ..
  3. doi request reprint Cerebellar volume is linked to cognitive function in temporal lobe epilepsy: a quantitative MRI study
    Sabine Hellwig
    Department of Psychiatry and Psychotherapy, University Hospital Freiburg, Freiburg, Germany
    Epilepsy Behav 28:156-62. 2013
    ....
  4. pmc Reelin together with ApoER2 regulates interneuron migration in the olfactory bulb
    Sabine Hellwig
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Freiburg, Germany
    PLoS ONE 7:e50646. 2012
    ..We identified ApoER2 as being the main receptor responsible for Reelin mediated detachment of neuroblasts and correct migration of early generated interneurons within the OB, a prerequisite for correct OB lamination...
  5. ncbi request reprint Negative amyloid PET imaging in a patient with probable Alzheimer's disease
    Sabine Hellwig
    Department of Psychiatry and Psychotherapy, University Hospital Freiburg, Freiburg, Germany
    Clin Nucl Med 36:1120-1. 2011
  6. doi request reprint Alzheimer's disease camouflaged by histrionic personality disorder
    Sabine Hellwig
    Department of Psychiatry and Psychotherapy, University Hospital Freiburg, Freiburg, Germany
    Neurocase 18:75-9. 2012
    ..The unusual coincidence of AD and a histrionic personality disorder hampered the clinical process of diagnosing dementia. We discuss unawareness as a complex concept incorporating neuroanatomical, psychiatric, and psychosocial aspects...
  7. doi request reprint Psychiatric comorbidity in patients with pharmacoresistant focal epilepsy and psychiatric outcome after epilepsy surgery
    Sabine Hellwig
    Department of Psychiatry and Psychotherapy, University Hospital Freiburg, Freiburg, Germany
    Epilepsy Behav 23:272-9. 2012
    ..Symptoms in 48% of patients with preoperative affective syndromes and 60% of patients with DD remitted after surgery. Seizure freedom and improved psychosocial status predicted remission of preoperative psychopathology...
  8. doi request reprint 123I-iodobenzamide SPECT is not an independent predictor of dopaminergic responsiveness in patients with suspected atypical parkinsonian syndromes
    Sabine Hellwig
    Department of Neurology, University Hospital Freiburg, Freiburg, Germany
    J Nucl Med 54:2081-6. 2013
    ..We investigated whether striatal dopamine D2/D3 receptor (D2R) binding assessed by (123)I-iodobenzamide SPECT is an independent predictor of dopaminergic responsiveness in patients with parkinsonism...
  9. doi request reprint Assessment of striatal dopamine D2/D3 receptor availability with PET and 18F-desmethoxyfallypride: comparison of imaging protocols suited for clinical routine
    Florian Amtage
    Department of Neurology, University Hospital Freiburg, Freiburg, Germany
    J Nucl Med 53:1558-64. 2012
    ..The present study was undertaken to define the optimal clinical scan protocol with regard to quantification accuracy and scan time...
  10. doi request reprint Syndrome-specific patterns of regional cerebral glucose metabolism in posterior cortical atrophy in comparison to dementia with lewy bodies and Alzheimer's disease-a [f-18]-fdg pet study
    Timo S Spehl
    Department of Nuclear Medicine, Freiburg, Germany
    J Neuroimaging 25:281-8. 2015
    ..Syndrome-specific patterns of metabolism have not yet been demonstrated that allow for a reliable differentiation with [F-18]-FDG-PET...
  11. doi request reprint Functional correlates of vertical gaze palsy and other ocular motor deficits in PSP: an FDG-PET study
    Florian Amtage
    Department of Neurology, University Medical Center Freiburg, Freiburg, Germany Freiburg Brain Imaging, University Medical Center Freiburg, Freiburg, Germany Electronic address
    Parkinsonism Relat Disord 20:898-906. 2014
    ..To determine the functional correlates of vertical gaze palsy and other ocular motor deficits in patients with progressive supranuclear palsy (PSP) using [(18)F]fluorodeoxyglucose (FDG-)PET...
  12. doi request reprint Neuronal correlates of clinical asymmetry in progressive supranuclear palsy
    Florian Amtage
    From the Department of Neurology, Freiburg Brain Imaging FBI, Department of Psychiatry and Psychotherapy, Department of Nuclear Medicine, University Medical Center Freiburg, Freiburg and Department of Psychiatry and Psychotherapy, University Medical Center Mainz, Mainz, Germany
    Clin Nucl Med 39:319-25. 2014
    ....
  13. doi request reprint Role of semiquantitative assessment of regional binding potential in 123I-FP-CIT SPECT for the differentiation of frontotemporal dementia, dementia with Lewy bodies, and Alzheimer's dementia
    Timo S Spehl
    From the Department of Nuclear Medicine, Centre of Geriatrics and Gerontology, Departments of Radiation Oncology, Psychiatry and Psychotherapy, and Neurology, University Hospital Freiburg, Freiburg, Germany
    Clin Nucl Med 40:e27-33. 2015
    ..The role of I-FP-CIT SPECT in frontotemporal dementia (FTD) is rather unclear, albeit nigrostriatal involvement may occur. The aim of this study was to evaluate its role in the differentiation of FTD, DLB, and AD...
  14. doi request reprint Role for Reelin in neurotransmitter release
    Sabine Hellwig
    Institut fur Anatomie und Zellbiologie, Albert Ludwigs Universitat Freiburg, Freiburg, Germany
    J Neurosci 31:2352-60. 2011
    ..Together, these novel findings suggest a role for Reelin in modulating presynaptic release mechanisms...
  15. doi request reprint Comparative analyses of Purkinje cell gene expression profiles reveal shared molecular abnormalities in models of different polyglutamine diseases
    Bernd Friedrich
    Department of Neurology, University Hospital Freiburg, Germany
    Brain Res 1481:37-48. 2012
    ..Furthermore, downregulation of mRNAs mediated by the Pcp2-promoter is common in both models. Thus, our data reveal shared molecular abnormalities in different polyQ disorders...
  16. doi request reprint Dual-biomarker imaging of regional cerebral amyloid load and neuronal activity in dementia with PET and 11C-labeled Pittsburgh compound B
    Philipp T Meyer
    Department of Nuclear Medicine, University Hospital Freiburg, Freiburg, Germany
    J Nucl Med 52:393-400. 2011
    ..We investigated the validity of relative regional CBF estimates (R(1)) gained from pharmacokinetic analyses of (11)C-labeled Pittsburgh compound B ((11)C-PIB) PET studies as a marker of neuronal activity and neurodegeneration...
  17. doi request reprint Image quality and data quantification in dopamine transporter SPECT: advantage of 3-dimensional OSEM reconstruction?
    Oliver H Winz
    Department of Nuclear Medicine, University Hospital Aachen, Aachen, The Netherlands
    Clin Nucl Med 37:866-71. 2012
    ..We investigated if image reconstruction by 3-dimensional ordered-subset expectation maximization (3D-OSEM) with resolution recovery, which has recently become available for clinical routine, provides a relevant improvement...
  18. doi request reprint Update on SPECT and PET in parkinsonism - part 2: biomarker imaging of cognitive impairment in Lewy-body diseases
    Philipp T Meyer
    aDepartment of Nuclear Medicine bCentre of Geriatrics and Gerontology cDepartment of Neurology dDepartment of Psychiatry and Psychotherapy, University Hospital Freiburg, Freiburg, Germany
    Curr Opin Neurol 27:398-404. 2014
    ..To give an update on recent biomarker imaging studies using single-photon emission computed tomography (SPECT) and positron emission tomography (PET) on cognitive impairment in Lewy-body diseases (LBD)...
  19. doi request reprint Update on SPECT and PET in parkinsonism - part 1: imaging for differential diagnosis
    Philipp T Meyer
    aDepartment of Nuclear Medicine bDepartment of Neurology cDepartment of Psychiatry and Psychotherapy, University Hospital Freiburg, Freiburg, Germany
    Curr Opin Neurol 27:390-7. 2014
    ....