C Hellerbrand

Summary

Affiliation: University of Regensburg
Country: Germany

Publications

  1. ncbi request reprint In situ expression patterns of melanoma inhibitory activity 2 in healthy and diseased livers
    Claus Hellerbrand
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Liver Int 25:357-66. 2005
  2. pmc DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma
    Elke Schaeffeler
    Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, Auerbachstrasse 112, 70376 Stuttgart, Germany
    Genome Med 3:82. 2011
  3. pmc Activating transcription factor-3 (ATF3) functions as a tumor suppressor in colon cancer and is up-regulated upon heat-shock protein 90 (Hsp90) inhibition
    Christina Hackl
    Department of Surgery, University of Regensburg Medical Center, Franz Josef Straus Allee 11, 93042 Regensburg, Germany
    BMC Cancer 10:668. 2010
  4. pmc ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma(HCC) cells, and inhibits growth and vascularization in vivo
    Christian Moser
    Department of Surgery, Regensburg Medical Center, Regensburg, Germany
    BMC Cancer 8:206. 2008
  5. ncbi request reprint Reduced expression of CYLD in human colon and hepatocellular carcinomas
    Claus Hellerbrand
    Department of Internal Medicine I, University Regensburg, 93053 Regensburg, Germany
    Carcinogenesis 28:21-7. 2007
  6. ncbi request reprint The novel gene MIA2 acts as a tumour suppressor in hepatocellular carcinoma
    C Hellerbrand
    University of Regensburg, Department of Internal Medicine I, D 93042 Regensburg, Germany
    Gut 57:243-51. 2008
  7. ncbi request reprint HFE C282Y heterozygosity in hepatocellular carcinoma: evidence for an increased prevalence
    Claus Hellerbrand
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Clin Gastroenterol Hepatol 1:279-84. 2003
  8. doi request reprint Pathophysiological similarities and synergisms in alcoholic and non-alcoholic steatohepatitis
    Claus Hellerbrand
    Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany
    Dig Dis 28:783-91. 2010
  9. ncbi request reprint Mutation analysis of the HFE gene in German hemochromatosis patients and controls using automated SSCP-based capillary electrophoresis and a new PCR-ELISA technique
    C Hellerbrand
    Dept of Internal Medicine I, University of Regensburg, Germany
    Scand J Gastroenterol 36:1211-6. 2001
  10. ncbi request reprint Hepatocellular carcinoma in southern Germany: epidemiological and clinicopathological characteristics and risk factors
    C Hellerbrand
    Department of Internal Medicine I, University of Regensburg, Germany
    Dig Dis 19:345-51. 2001

Detail Information

Publications73

  1. ncbi request reprint In situ expression patterns of melanoma inhibitory activity 2 in healthy and diseased livers
    Claus Hellerbrand
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Liver Int 25:357-66. 2005
    ..Here, we analyzed the in situ expression of MIA2 protein and mRNA in healthy and diseased livers to get first insights into the function of MIA2...
  2. pmc DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma
    Elke Schaeffeler
    Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, Auerbachstrasse 112, 70376 Stuttgart, Germany
    Genome Med 3:82. 2011
    ..Therefore, we investigated the role of DNA methylation in the transcriptional regulation of the family members SLC22A1/OCT1, SLC22A2/OCT2 and SLC22A3/OCT3 in HCC...
  3. pmc Activating transcription factor-3 (ATF3) functions as a tumor suppressor in colon cancer and is up-regulated upon heat-shock protein 90 (Hsp90) inhibition
    Christina Hackl
    Department of Surgery, University of Regensburg Medical Center, Franz Josef Straus Allee 11, 93042 Regensburg, Germany
    BMC Cancer 10:668. 2010
    ..Here we followed-up on our previous observation that inhibition of Hsp90 may increase ATF3 expression and sought to determine the role of ATF3 in colon cancer...
  4. pmc ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma(HCC) cells, and inhibits growth and vascularization in vivo
    Christian Moser
    Department of Surgery, Regensburg Medical Center, Regensburg, Germany
    BMC Cancer 8:206. 2008
    ..We hypothesized that therapeutic inhibition of HIF-1alpha could be achieved by using a novel tubulin-binding agent (ENMD-1198). ENMD-1198 is an analog of 2-methoxyestradiol (2ME2) with antiproliferative and antiangiogenic activity...
  5. ncbi request reprint Reduced expression of CYLD in human colon and hepatocellular carcinomas
    Claus Hellerbrand
    Department of Internal Medicine I, University Regensburg, 93053 Regensburg, Germany
    Carcinogenesis 28:21-7. 2007
    ..Thus, functional relevant loss of CYLD expression may contribute to tumor development and progression, and may provide a new target for therapeutic strategies...
  6. ncbi request reprint The novel gene MIA2 acts as a tumour suppressor in hepatocellular carcinoma
    C Hellerbrand
    University of Regensburg, Department of Internal Medicine I, D 93042 Regensburg, Germany
    Gut 57:243-51. 2008
    ..The selective expression of MIA2 in hepatocytes is controlled by hepatocyte nuclear factor (HNF) 1 binding sites in the MIA2 promotor. In contrast, in most hepatocellular carcinomas (HCC) MIA2 expression is down-regulated or lost...
  7. ncbi request reprint HFE C282Y heterozygosity in hepatocellular carcinoma: evidence for an increased prevalence
    Claus Hellerbrand
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Clin Gastroenterol Hepatol 1:279-84. 2003
    ..The discovery of the HH gene HFE has enabled identification of the heterozygote status. The aim of this study was to evaluate if heterozygosity for HH is a risk factor for HCC...
  8. doi request reprint Pathophysiological similarities and synergisms in alcoholic and non-alcoholic steatohepatitis
    Claus Hellerbrand
    Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany
    Dig Dis 28:783-91. 2010
    ..Undoubtedly, alcohol and the metabolic syndrome appear as a dangerous mix, and there are important synergistic effects of either condition with regard to crucial triggers of liver injury...
  9. ncbi request reprint Mutation analysis of the HFE gene in German hemochromatosis patients and controls using automated SSCP-based capillary electrophoresis and a new PCR-ELISA technique
    C Hellerbrand
    Dept of Internal Medicine I, University of Regensburg, Germany
    Scand J Gastroenterol 36:1211-6. 2001
    ....
  10. ncbi request reprint Hepatocellular carcinoma in southern Germany: epidemiological and clinicopathological characteristics and risk factors
    C Hellerbrand
    Department of Internal Medicine I, University of Regensburg, Germany
    Dig Dis 19:345-51. 2001
    ..This study analyses the characteristics of HCC patients in southern Germany, a low endemic area of HCC...
  11. ncbi request reprint Olive oil attenuates the cholesterol-induced development of nonalcoholic steatohepatitis despite increased insulin resistance in a rodent model
    R Buettner
    Department of Internal Medicine I, University Medical Center Regensburg, Regensburg, Germany
    Horm Metab Res 45:795-801. 2013
    ..However, dietary cholesterol is an important causal agent for the development of NASH. Olive oil plays a protective role in this respect, which might be due to the high content of monounsaturated fatty acids. ..
  12. doi request reprint Dietary folic acid activates AMPK and improves insulin resistance and hepatic inflammation in dietary rodent models of the metabolic syndrome
    R Buettner
    Department of Internal Medicine I, University Medical Center Regensburg, Regensburg, Germany
    Horm Metab Res 42:769-74. 2010
    ..Dietary folic acid improved parameters of insulin resistance and hepatic inflammation in rodent models. This might be due to an increased AMK activation...
  13. ncbi request reprint Promoter-hypermethylation is causing functional relevant downregulation of methylthioadenosine phosphorylase (MTAP) expression in hepatocellular carcinoma
    Claus Hellerbrand
    Department of Internal Medicine I and Institute of Pathology, University of Regensburg, D 93042 Regensburg, Germany
    Carcinogenesis 27:64-72. 2006
    ..Furthermore, in the light of a recent report revealing an association between MTAP activity and IFN sensitivity, our findings may have clinical significance for therapeutic strategies...
  14. ncbi request reprint A novel MCP-1 gene polymorphism is associated with hepatic MCP-1 expression and severity of HCV-related liver disease
    Marcus Muhlbauer
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Gastroenterology 125:1085-93. 2003
    ..In this study, we investigated the correlation of the functional -2518 MCP-1 promoter polymorphism with hepatic MCP-1 expression and the disease outcome in patients with HCV...
  15. doi request reprint Bone morphogenetic protein 4 is induced in hepatocellular carcinoma by hypoxia and promotes tumour progression
    Ulrike Maegdefrau
    Institute of Pathology, University of Regensburg, Germany
    J Pathol 218:520-9. 2009
    ..Therefore, BMP4 expression may have clinical relevance, and interfering with BMP4 signalling appears as an attractive therapeutic target for this highly aggressive tumour...
  16. ncbi request reprint Loss of E-cadherin leads to upregulation of NFkappaB activity in malignant melanoma
    S Kuphal
    Institute of Pathology, University of Regensburg, Franz Josef Strauss Allee 11, D 93053 Regensburg, Germany
    Oncogene 23:8509-19. 2004
    ..In summary, we conclude that loss of E-cadherin and cytoplasmatic beta-catenin induces p38-mediated NFkappaB activation, potentially revealing an important mechanism of tumorigenesis in malignant melanomas...
  17. ncbi request reprint Different effects of a CD14 gene polymorphism on disease outcome in patients with alcoholic liver disease and chronic hepatitis C infection
    C Meiler
    Department of Internal Medicine I, University of Regensburg, Regensburg D 93042, Germany
    World J Gastroenterol 11:6031-7. 2005
    ..Here, we investigated this polymorphism in patients with less advanced alcoholic liver disease (ALD) and chronic hepatitis C virus (HCV) infection...
  18. ncbi request reprint Hepatitis C - contamination of toothbrushes: myth or reality?
    G Lock
    Albertinenkrankenhaus Hamburg, 2nd Medical Department, University of Regensburg, Regensburg, Germany
    J Viral Hepat 13:571-3. 2006
    ....
  19. pmc GLUT1 expression is increased in hepatocellular carcinoma and promotes tumorigenesis
    Thomas Amann
    University of Regensburg, Department of Internal Medicine I, D 93042 Regensburg, Germany
    Am J Pathol 174:1544-52. 2009
    ..In summary, our findings suggest that increased GLUT1 expression levels in HCC cells functionally affect tumorigenicity, and thus, we propose GLUT1 as an innovative therapeutic target for this highly aggressive tumor...
  20. ncbi request reprint [Liver histology in hepatitis C: correlation with different biochemical and virological parameters]
    G Lock
    Klinik und Poliklinik für Innere Medizin I, Universitatsklinikum, D 93042 Regensburg
    Med Klin (Munich) 95:603-7. 2000
    ..This study aimed at investigating the correlation between different biochemical and virological parameters and histological scores of inflammation and fibrosis in chronic hepatitis C...
  21. ncbi request reprint Adiponectin and its receptors in rodent models of fatty liver disease and liver cirrhosis
    Markus Neumeier
    Department of Internal Medicine I, University of Regensburg, Regensburg D 93042, Germany
    World J Gastroenterol 12:5490-4. 2006
    ..To determine circulating and hepatic adiponectin in rodents with fatty liver disease or liver cirrhosis and investigate expression of the adiponectin receptors AdipoR1 on the mRNA and protein level and AdipoR2 on the mRNA level...
  22. ncbi request reprint Xanthohumol, a chalcon derived from hops, inhibits hepatic inflammation and fibrosis
    Christoph Dorn
    Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany
    Mol Nutr Food Res 54:S205-13. 2010
    ..These data indicate that XN has the potential as functional nutrient for the prevention or treatment of non-alcoholic steatohepatitis or other chronic liver disease...
  23. pmc Reduced expression of fibroblast growth factor receptor 2IIIb in hepatocellular carcinoma induces a more aggressive growth
    Thomas Amann
    University of Regensburg, Department of Internal Medicine I, D 93042 Regensburg, Germany
    Am J Pathol 176:1433-42. 2010
    ..Identification of the molecular mechanisms promoting regeneration in normal tissue while suppressing malignancy may lead to novel therapeutic targets of this highly aggressive tumor...
  24. doi request reprint Elevated adiponectin serum levels in patients with chronic alcohol abuse rapidly decline during alcohol withdrawal
    Christa Buechler
    Department of Internal Medicine I, University of Regensburg, Regensburg D 93042, Germany
    J Gastroenterol Hepatol 24:558-63. 2009
    ..Adiponectin is a circulating protein with hepatoprotective effects. Aims: To study the relationship of excessive alcohol consumption and serum adiponectin levels (SAL)...
  25. ncbi request reprint Repression of cytochrome P450 activity in human hepatocytes in vitro by a novel hepatotrophic factor, augmenter of liver regeneration
    Wolfgang E Thasler
    Center for Liver Cell Research, University of Regensburg Hospital, Germany
    J Pharmacol Exp Ther 316:822-9. 2006
    ..These findings further imply a possible role of ALR in drug interactions during impaired hepatic function, whereas liver regeneration is triggered...
  26. doi request reprint Uncoupling of sympathetic nervous system and hypothalamic-pituitary-adrenal axis in cirrhosis
    Reiner Wiest
    Department of Internal Medicine, Regensburg University Medical Center, Regensburg, Germany
    J Gastroenterol Hepatol 23:1901-8. 2008
    ..This physiological synergism of the axes aims at optimizing anti-inflammatory actions. Therefore, we investigated whether this synergism is altered in patients with liver cirrhosis...
  27. ncbi request reprint Correlation between iron status and genetic hemochromatosis (codon C282Y) in a large German population
    Christian E Wrede
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Isr Med Assoc J 6:30-3. 2004
    ..Representative population studies are needed to evaluate the phenotype of people heterozygous and homozygous for the C282Y mutation...
  28. doi request reprint Sterol regulatory element-binding protein 2 (SREBP2) activation after excess triglyceride storage induces chemerin in hypertrophic adipocytes
    Sabrina Bauer
    Department of Internal Medicine I, Regensburg University Hospital, D 93042 Regensburg, Germany
    Endocrinology 152:26-35. 2011
    ..In conclusion, the current data show that adipocyte hypertrophy and chronic inflammation are equally important in inducing chemerin synthesis...
  29. ncbi request reprint Polymorphism of monocyte chemoattractant protein 1 in Crohn's disease
    Hans Herfarth
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    Int J Colorectal Dis 18:401-5. 2003
    ..Furthermore, we studied whether a functional single nucleotide polymorphism (G or A) located in the distal regulatory region of the MCP-1 gene is associated with Crohn's disease and/or its phenotype...
  30. ncbi request reprint The -2518 promotor polymorphism in the MCP-1 gene is associated with systemic sclerosis
    Sigrid Karrer
    Department of Dermatology, University of Regensburg, Regensburg, Germany
    J Invest Dermatol 124:92-8. 2005
    ..The A -2518G polymorphism of the MCP-1 gene appears to affect MCP-1 expression of skin fibroblasts of patients with SSc. In accordance, the G/G genotype may predispose patients to SSc...
  31. ncbi request reprint Lack of association between the functional CX3CR1 polymorphism V249I and hepatocellular carcinoma
    Marcus Muhlbauer
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Oncol Rep 13:957-63. 2005
    ....
  32. doi request reprint Quantification of intermediates of the methionine and polyamine metabolism by liquid chromatography-tandem mass spectrometry in cultured tumor cells and liver biopsies
    Axel P Stevens
    Institute of Functional Genomics, University of Regensburg, Josef Engert Str 9, 93053 Regensburg, Germany
    J Chromatogr A 1217:3282-8. 2010
    ....
  33. ncbi request reprint Specific expression and regulation of the new melanoma inhibitory activity-related gene MIA2 in hepatocytes
    Anja K Bosserhoff
    Institute of Pathology and Department of Internal Medicine I, University of Regensburg, 93053 Regensburg, Germany
    J Biol Chem 278:15225-31. 2003
    ..The increased transcription in more severe chronic liver disease suggests that MIA2 may serve as a marker of hepatic disease activity and severity...
  34. ncbi request reprint FHL2 suppresses growth and differentiation of the colon cancer cell line HT-29
    Thomas Amann
    Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany
    Oncol Rep 23:1669-74. 2010
    ....
  35. doi request reprint Activated hepatic stellate cells promote tumorigenicity of hepatocellular carcinoma
    Thomas Amann
    Department of Internal Medicine I, University of Regensburg, D 93053, Regensburg, Germany
    Cancer Sci 100:646-53. 2009
    ..In summary, our data indicate that stromal HSC promotes HCC progression and suggest the HSC-HCC interaction as an interesting tumor differentiation-independent target for therapy of this highly aggressive cancer...
  36. ncbi request reprint Xanthohumol, a prenylated chalcone derived from hops, inhibits proliferation, migration and interleukin-8 expression of hepatocellular carcinoma cells
    Christoph Dorn
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Int J Oncol 36:435-41. 2010
    ..In summary, our data showed that xanthohumol can ameliorate different pro-tumorigenic mechanisms known to promote HCC progression, indicating its potential as promising therapeutic agent that selectively affects cancer cells...
  37. ncbi request reprint Differential effects of deoxycholic acid and taurodeoxycholic acid on NF-kappa B signal transduction and IL-8 gene expression in colonic epithelial cells
    M Muhlbauer
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Am J Physiol Gastrointest Liver Physiol 286:G1000-8. 2004
    ..These differences may have implications for the understanding of the pathophysiology of inflammation and carcinogenesis in the gut...
  38. ncbi request reprint Association between serum ferritin and the insulin resistance syndrome in a representative population
    C E Wrede
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    Eur J Endocrinol 154:333-40. 2006
    ..However, as yet the association between IRS and SF in a representative population has not been investigated...
  39. ncbi request reprint Expression of E-selectin ligand-1 (CFR/ESL-1) on hepatic stellate cells: implications for leukocyte extravasation and liver metastasis
    Marianne Antoine
    Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, D 93042 Regensburg, Germany
    Oncol Rep 21:357-62. 2009
    ..Therefore, we hypothesize that under hypoxia, ESL-1 is shed from activated HSC. Our findings provide a novel perspective on the function of HSC in liver metastasis and inflammatory liver diseases...
  40. ncbi request reprint Characterization of the human zinc finger protein 267 promoter: essential role of nuclear factor Y
    Kanghong Hu
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    Biochim Biophys Acta 1729:14-23. 2005
    ....
  41. pmc Dietary glycine blunts liver injury after bile duct ligation in rats
    Matthias Froh
    Department of Internal Medicine I, University of Regensburg, Regensburg 93042, Germany
    World J Gastroenterol 14:5996-6003. 2008
    ..To investigate the effects of (dietary) glycine against oxidant-induced injury caused by bile duct ligation (BDL)...
  42. ncbi request reprint Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10
    Bernd Schnabl
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Biochem Biophys Res Commun 335:87-96. 2005
    ..In conclusion, our results suggest that ZNF267 as a negative transcriptional regulator of MMP-10 might promote liver fibrogenesis through alteration of matrix degradation in vivo...
  43. doi request reprint Iron-induced expression of bone morphogenic protein 6 in intestinal cells is the main regulator of hepatic hepcidin expression in vivo
    Stephanie Arndt
    Institute of Pathology, University of Regensburg, Regensburg, Germany
    Gastroenterology 138:372-82. 2010
    ..Recent studies identified bone morphogenic protein 6 (BMP6) as a key regulator of hepatic hepcidin expression and iron metabolism, but the cellular source of BMP6 and the reason for its specific effect on hepatocytes are unknown...
  44. doi request reprint GLUT1 as a therapeutic target in hepatocellular carcinoma
    Thomas Amann
    University Hospital Regensburg, Department of Internal Medicine I, D 93042 Regensburg, Germany
    Expert Opin Ther Targets 13:1411-27. 2009
    ..This review summarizes our current knowledge on the expression and function of GLUT1 in HCC, available drugs/strategies to inhibit GLUT1 expression or function, and potential side effects of such therapeutic strategies...
  45. ncbi request reprint LPS-mediated NFkappaB activation varies between activated human hepatic stellate cells from different donors
    Marcus Muhlbauer
    Department of Internal Medicine I, University of Regensburg, Germany
    Biochem Biophys Res Commun 325:191-7. 2004
    ....
  46. ncbi request reprint PD-L1 is induced in hepatocytes by viral infection and by interferon-alpha and -gamma and mediates T cell apoptosis
    Marcus Muhlbauer
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    J Hepatol 45:520-8. 2006
    ..Absence of PD-1 enhanced proliferation of T cells in adenovirus-infected livers and resulted in a rapid clearance of the virus. Here, we aimed to get more insight into hepatic PD-L1 expression, regulation and function...
  47. ncbi request reprint Raf kinase inhibitor protein is downregulated in hepatocellular carcinoma
    Marion M Schuierer
    Institute of Pathology, University of Regensburg, 93053 Regensburg, Germany
    Oncol Rep 16:451-6. 2006
    ..In addition, our study demonstrates functional relevance of downregulation of RKIP in HCC that may play an important role in HCC development and progression...
  48. pmc Analysis of monocyte chemotactic protein-1 gene polymorphism in patients with spontaneous bacterial peritonitis
    Erwin Gabele
    Department of Internal Medicine I, University Medical Center Regensburg, Regensburg, Germany
    World J Gastroenterol 15:5558-62. 2009
    ..To investigate a genetic polymorphism of the monocyte chemotactic protein-1 (MCP-1) gene in patients with spontaneous bacterial peritonitis (SBP)...
  49. pmc Expression of fatty acid synthase in nonalcoholic fatty liver disease
    Christoph Dorn
    Department of Internal Medicine I, University Hospital Regensburg, D 93042 Regensburg, Germany
    Int J Clin Exp Pathol 3:505-14. 2010
    ....
  50. ncbi request reprint Lipid accumulation in hepatocytes induces fibrogenic activation of hepatic stellate cells
    Hella Wobser
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Cell Res 19:996-1005. 2009
    ..Herewith, this study provides an attractive in vitro model to study the molecular mechanisms of steatosis-induced fibrogenesis, and to identify and test novel targets for antifibrotic therapies in fatty liver disease...
  51. doi request reprint Role of TLR9 in hepatic stellate cells and experimental liver fibrosis
    Erwin Gabele
    Department of Internal Medicine I, University of Regensburg, Franz Josef Strauss Alle 11, D 93042 Regensburg, Germany
    Biochem Biophys Res Commun 376:271-6. 2008
    ..In addition, the expression of hepatic alpha-smooth-muscle actin, a known marker for HSC activation, was reduced in TLR9-/- mice indicating that bacterial DNA induces the activation of HSC and therefore promotes hepatic fibrosis...
  52. ncbi request reprint Expression and function of fibroblast growth factor (FGF) 9 in hepatic stellate cells and its role in toxic liver injury
    Marianne Antoine
    Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Franz Josef Strauss Allee 11, D 93042 Regensburg, Germany
    Biochem Biophys Res Commun 361:335-41. 2007
    ..Our findings suggest that HSC FGF9 provide a paracrine mitogenic signal to hepatocytes during acute liver injury, while the autocrine FGF9 signaling appears to be not sufficient to induce cell proliferation...
  53. ncbi request reprint Ligation versus propranolol for the primary prophylaxis of variceal bleeding in cirrhosis
    Michael Schepke
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Hepatology 40:65-72. 2004
    ..In conclusion, VBL and PPL were similarly effective for primary prophylaxis of variceal bleeding. VBL should be offered to patients who are not candidates for long-term PPL treatment...
  54. doi request reprint Xanthohumol feeding does not impair organ function and homoeostasis in mice
    Christoph Dorn
    Department of Internal Medicine I, University Hospital Regensburg, Germany
    Food Chem Toxicol 48:1890-7. 2010
    ..Particularly, hepatotoxic effects could be ruled out confirming a good safety profile of xanthohumol as prerequisite for further studies in humans...
  55. pmc Role of HSP-90 for increased nNOS-mediated vasodilation in mesenteric arteries in portal hypertension
    Lukas Moleda
    Department of Internal Medicine I, University Medical Center, D 93042 Regensburg, Germany
    World J Gastroenterol 16:1837-44. 2010
    ..To explore the role of heat shock protein-90 (HSP-90) for nitrergic vasorelaxation in the splanchnic circulation in rats with and without portal hypertension...
  56. doi request reprint Lactic acid and acidification inhibit TNF secretion and glycolysis of human monocytes
    Katrin Dietl
    Department of Hematology and Oncology, University of Regensburg, Regensburg, Germany
    J Immunol 184:1200-9. 2010
    ..These results support the hypothesis that TNF secretion by human monocytes depends on glycolysis and suggest that LA and acidification may be involved in the suppression of TNF secretion in the tumor environment...
  57. ncbi request reprint Elevation of endoglin (CD105) concentrations in serum of patients with liver cirrhosis and carcinoma
    Eray Yagmur
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital Aachen, Germany
    Eur J Gastroenterol Hepatol 19:755-61. 2007
    ..The aim of this study was to evaluate circulating endoglin (CD105) in the serum of patients with liver cirrhosis and at high risk for HCC...
  58. ncbi request reprint Analysis of the transforming growth factor-beta1 (TGF-beta1) codon 25 gene polymorphism by LightCycler-analysis in patients with chronic hepatitis C infection
    Carmen G Tag
    Institute of Clinical Chemistry and Pathobiochemistry, RWTH University Hospital, Pauwelsstr 30, D 52074, Aachen, Germany
    Cytokine 24:173-81. 2003
    ..This suggests that the stage of hepatic fibrosis, rather than the grade (inflammation), is influenced by the presence of proline at codon 25 in patients with chronic hepatitis C...
  59. pmc Activated hepatic stellate cells express keratinocyte growth factor in chronic liver disease
    Heike Steiling
    Department of Biology, Institute of Cell Biology, Swiss Federal Institute of Technology, Zurich, Switzerland
    Am J Pathol 165:1233-41. 2004
    ..Based on the known effects of KGF on hepatocytes in vitro, our findings suggest that HSC/myofibroblast-derived KGF may enhance liver regeneration and/or hepatocyte survival in patients with chronic liver disease...
  60. ncbi request reprint Strong expression of methylthioadenosine phosphorylase (MTAP) in human colon carcinoma cells is regulated by TCF1/[beta]-catenin
    Frauke Bataille
    Institute of Pathology, University of Regensburg Medical School, Regensburg, Germany
    Lab Invest 85:124-36. 2005
    ..This finding may be of clinical significance concerning the homeostasis of normal colon epithelium and potential treatment of colon carcinoma...
  61. ncbi request reprint Transforming growth factor-beta1 gene polymorphisms are associated with progression of liver fibrosis in Caucasians with chronic hepatitis C infection
    Hao Wang
    Department of Laboratory Medicine, Changzheng Hospital, Second Military Medical University, Shanghai, China
    World J Gastroenterol 11:1929-36. 2005
    ..For this reason, much emphasis has been placed on studies elucidating the impact of TGF-beta1 and its gene variations for the susceptibility and pathogenesis of these diseases. Unfortunately, some studies have serious limitations...
  62. ncbi request reprint Association of myeloperoxidase promotor polymorphism with cirrhosis in patients with hereditary hemochromatosis
    Christoph H Osterreicher
    Department of Internal Medicine IV, Gastroenterology and Hepatology, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Wien, Austria
    J Hepatol 42:914-9. 2005
    ..This study assessed the impact of polymorphisms of the MPO (-463G/A) and the HO-1 promotors of Vienna (GT)n on the evolution of cirrhosis in patients with HHC...
  63. ncbi request reprint TGF-beta1 codon 25 gene polymorphism is associated with cirrhosis in patients with hereditary hemochromatosis
    Christoph H Osterreicher
    Department of Internal Medicine IV, Medical University of Vienna, Austria
    Cytokine 31:142-8. 2005
    ..8 (95% CI 1.4-5.7, p = 0.004). In conclusion, C282Y homozygotes carrying TGF-beta1 genotypes Arg/Pro and Pro/Pro are more likely to develop cirrhosis than those with genotype Arg/Arg...
  64. ncbi request reprint Alcohol dehydrogenase 1C*1 allele is a genetic marker for alcohol-associated cancer in heavy drinkers
    Nils Homann
    Department of Medicine I, University of Lubeck, Germany
    Int J Cancer 118:1998-2002. 2006
    ..11-4.36), respectively. The data identify genotype ADH1C*1/1 as an independent risk factor for the development of alcohol-associated tumors among heavy drinkers, indicating a genetic predisposition of individuals carrying this genotype...
  65. ncbi request reprint Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans
    Sonja Hillebrandt
    Department of Medicine III, University Hospital Aachen, Aachen University, Aachen, Germany
    Nat Genet 37:835-43. 2005
    ..Thus, the mouse quantitative trait gene led to the identification of an unknown gene underlying human susceptibility to liver fibrosis, supporting the idea that C5 has a causal role in fibrogenesis across species...
  66. ncbi request reprint Prediction of progression to cirrhosis by a glutathione S-transferase P1 polymorphism in subjects with hereditary hemochromatosis
    Felix Stickel
    Department of Medicine I, University of Erlangen Nurnberg, Erlangen, Germany
    Arch Intern Med 165:1835-40. 2005
    ..Our objective was to establish the role of the functional polymorphisms of GSTP1 (codon 105 Ile-->Val) and MnSOD (codon 16 of precursor protein Ala-->Val) on the evolution of cirrhosis in patients with HHC and CHC...
  67. doi request reprint No role of matrixmetalloproteinase-3 genetic promoter polymorphism 1171 as a risk factor for cirrhosis in alcoholic liver disease
    Felix Stickel
    Institute of Clinical Pharmacology, University of Berne, Switzerland
    Alcohol Clin Exp Res 32:959-65. 2008
    ..We tested whether a functional promoter polymorphism in the gene encoding matrix metalloproteinase-3 (MMP-3; 1171 5A/6A) was associated liver cirrhosis in alcoholics...
  68. ncbi request reprint Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells
    Frank Tacke
    Medical Clinic III, University Hospital Aachen, Aachen, Germany
    Dig Dis Sci 52:3404-15. 2007
    ..Elevated systemic and hepatic levels of BMP7 in patients with chronic liver disease may contribute to progression of liver fibrogenesis in vivo...
  69. doi request reprint Evaluation of the transforming growth factor beta1 codon 25 (Arg-->Pro) polymorphism in alcoholic liver disease
    Christoph H Osterreicher
    Department of Medicine, University of California, San Diego, Leichtag Building, Room 349 I, 9500 Gilman Drive, 0702, La Jolla, CA 92093 0702, USA
    Cytokine 42:18-23. 2008
    ..Its contribution to the progression of ALD has not been investigated sufficiently so far...
  70. ncbi request reprint The fractalkine receptor CX3CR1 is involved in liver fibrosis due to chronic hepatitis C infection
    Hermann E Wasmuth
    Medical Department III, University Hospital Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
    J Hepatol 48:208-15. 2008
    ..The chemokine receptor CX3CR1 and its specific ligand fractalkine (CX3CL1) are known to modulate inflammatory and fibroproliferative diseases. Here we investigate the role of CX3CR1/fractalkine in HCV-induced liver fibrosis...
  71. ncbi request reprint Up-regulated eotaxin plasma levels in chronic liver disease patients indicate hepatic inflammation, advanced fibrosis and adverse clinical course
    Frank Tacke
    Medical Clinic III, University Hospital Aachen, Aachen, Germany
    J Gastroenterol Hepatol 22:1256-64. 2007
    ..The aim of this study was to analyze the role of eotaxin in chronic liver disease...
  72. doi request reprint A TLR4/MD2 fusion protein inhibits LPS-induced pro-inflammatory signaling in hepatic stellate cells
    Bernd Schnabl
    Department of Medicine, University of California San Diego, 9500 Gilman Drive, MC0702, La Jolla, CA 92093, USA
    Biochem Biophys Res Commun 375:210-4. 2008
    ..In addition, TLR4/MD2 fused to human IgG-Fc neutralized LPS activity. Since TLR4 mutant mice are resistant to liver fibrosis, the TLR4/MD2 soluble receptor might represent a new therapeutic molecule for liver fibrogenesis in vivo...
  73. doi request reprint The Nrf2 transcription factor protects from toxin-induced liver injury and fibrosis
    Weihua Xu
    Department of Biology, Institute of Cell Biology, ETH Zurich, Switzerland
    Lab Invest 88:1068-78. 2008
    ..These results suggest that activation of Nrf2 may be a novel strategy to prevent or ameliorate toxin-induced liver injury and fibrosis...