Ulrich Hegerl

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi request reprint The alliance against depression: 2-year evaluation of a community-based intervention to reduce suicidality
    Ulrich Hegerl
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Psychol Med 36:1225-33. 2006
  2. ncbi request reprint Anterior cingulum volumetry, auditory P300 in schizophrenia with negative symptoms
    Ulrich W Preuss
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstrasse 7, D 80336 Munich, Germany
    Psychiatry Res 183:133-9. 2010
  3. doi request reprint Attention to emotion: auditory-evoked potentials in an emotional choice reaction task and personality traits as assessed by the NEO FFI
    Verena Mittermeier
    Department of Psychiatry and Psychotherapy, LMU, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 261:111-20. 2011
  4. doi request reprint Reduced early auditory evoked gamma-band response in patients with schizophrenia
    Gregor Leicht
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, 7D 80336 Munich, Germany
    Biol Psychiatry 67:224-31. 2010
  5. ncbi request reprint Electrophysiological evidence for cortical abnormalities in obsessive-compulsive disorder - a replication study using auditory event-related P300 subcomponents
    Doris Gohle
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    J Psychiatr Res 42:297-303. 2008
  6. ncbi request reprint [123I] ADAM brainstem binding correlates with the loudness dependence of auditory evoked potentials
    Oliver Pogarell
    Dept of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 258:40-7. 2008
  7. doi request reprint Serotonergic functioning as measured by the loudness dependence of auditory evoked potentials is related to a haplotype in the brain-derived neurotrophic factor (BDNF) gene
    Georg Juckel
    Department of Psychiatry, Ruhr University, 44791 Bochum, Germany
    J Psychiatr Res 44:541-6. 2010
  8. doi request reprint Loudness dependence of auditory evoked potentials in patients with borderline personality disorder--impact of psychopathology
    Nadine Schaaff
    Department of Psychiatry, Ludwig Maximilian University of Munich, Germany
    Psychiatry Res 199:181-7. 2012
  9. ncbi request reprint Inefficient neural activity in patients with schizophrenia and nonpsychotic relatives of schizophrenic patients: evidence from a working memory task
    Susanne Karch
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstrasse 7, D 80336 Munich, Germany
    J Psychiatr Res 43:1185-94. 2009
  10. ncbi request reprint Association of catechol-O-methyltransferase variants with loudness dependence of auditory evoked potentials
    Georg Juckel
    Department of Psychiatry, Ruhr University Bochum, Germany
    Hum Psychopharmacol 23:115-20. 2008

Detail Information

Publications93

  1. ncbi request reprint The alliance against depression: 2-year evaluation of a community-based intervention to reduce suicidality
    Ulrich Hegerl
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Psychol Med 36:1225-33. 2006
    ..The aim of the Nuremberg Alliance against Depression (NAD) is to establish and to assess the effectiveness of a four-level intervention program for improving the care of patients with depression...
  2. ncbi request reprint Anterior cingulum volumetry, auditory P300 in schizophrenia with negative symptoms
    Ulrich W Preuss
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstrasse 7, D 80336 Munich, Germany
    Psychiatry Res 183:133-9. 2010
    ..In addition, while right hemisphere ACC volumes significantly differ between schizophrenia subgroups, combining measures of event-related potential (ERP) and ACC volumetry does not add additional information...
  3. doi request reprint Attention to emotion: auditory-evoked potentials in an emotional choice reaction task and personality traits as assessed by the NEO FFI
    Verena Mittermeier
    Department of Psychiatry and Psychotherapy, LMU, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 261:111-20. 2011
    ..Interestingly, subjects with high scores in the personality trait extraversion showed significantly higher EPN amplitudes for emotional paradigms (syllables and words) than introverted subjects...
  4. doi request reprint Reduced early auditory evoked gamma-band response in patients with schizophrenia
    Gregor Leicht
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, 7D 80336 Munich, Germany
    Biol Psychiatry 67:224-31. 2010
    ..power and phase-locking in schizophrenic patients?; and 2) Is this possible decrease a result of reduced activity in the auditory cortex and/or the anterior cingulate cortex (ACC), which were identified as sources of the GBR previously?..
  5. ncbi request reprint Electrophysiological evidence for cortical abnormalities in obsessive-compulsive disorder - a replication study using auditory event-related P300 subcomponents
    Doris Gohle
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    J Psychiatr Res 42:297-303. 2008
    ..Once again, our findings point to a hyperactivated cortical state also of temporo-parietal and hippocampal regions in OCD...
  6. ncbi request reprint [123I] ADAM brainstem binding correlates with the loudness dependence of auditory evoked potentials
    Oliver Pogarell
    Dept of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 258:40-7. 2008
    ..01). Associations between LD and SERT availability contribute to the understanding of the central serotonergic system and further validate the use of neurophysiological approaches as indirect measures of neurochemical brain activity...
  7. doi request reprint Serotonergic functioning as measured by the loudness dependence of auditory evoked potentials is related to a haplotype in the brain-derived neurotrophic factor (BDNF) gene
    Georg Juckel
    Department of Psychiatry, Ruhr University, 44791 Bochum, Germany
    J Psychiatr Res 44:541-6. 2010
    ..To evaluate the genetic basis of this relationship, we studied whether the LDAEP is correlated with genetic variants within the BDNF gene...
  8. doi request reprint Loudness dependence of auditory evoked potentials in patients with borderline personality disorder--impact of psychopathology
    Nadine Schaaff
    Department of Psychiatry, Ludwig Maximilian University of Munich, Germany
    Psychiatry Res 199:181-7. 2012
    ..The significant clinical correlations suggest monoaminergic modulations of psychopathology on the symptom level...
  9. ncbi request reprint Inefficient neural activity in patients with schizophrenia and nonpsychotic relatives of schizophrenic patients: evidence from a working memory task
    Susanne Karch
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstrasse 7, D 80336 Munich, Germany
    J Psychiatr Res 43:1185-94. 2009
    ..In addition, compensatory strategies were demonstrated. These findings suggest that the genetic risk for schizophrenia is accompanied by neural inefficiency which is associated with cognitive deficits, especially in difficult tasks...
  10. ncbi request reprint Association of catechol-O-methyltransferase variants with loudness dependence of auditory evoked potentials
    Georg Juckel
    Department of Psychiatry, Ruhr University Bochum, Germany
    Hum Psychopharmacol 23:115-20. 2008
    ..The aim of this study was to investigate the relationship between genetic variants of the COMT gene influencing synaptic dopamine levels and the LDAEP...
  11. ncbi request reprint Acute prefrontal rTMS increases striatal dopamine to a similar degree as D-amphetamine
    Oliver Pogarell
    Department of Psychiatry, Ludwig Maximilians University of Munich, Munich, Germany
    Psychiatry Res 156:251-5. 2007
    ..95% (difference not statistically significant). Acute rTMS challenge showed similar striatal dopaminergic effects to those associated with the administration of d-amphetamine, a substance known to increase synaptic dopamine...
  12. ncbi request reprint Influence of trait anxiety on inhibitory control in alcohol-dependent patients: simultaneous acquisition of ERPs and BOLD responses
    Susanne Karch
    Department of Psychiatry, Ludwig Maximilians University of Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    J Psychiatr Res 42:734-45. 2008
    ..This may indicate that comorbid psychiatric symptoms need to be considered when assessing brain responses in alcohol-dependent patients...
  13. doi request reprint Dopaminergic mechanisms of target detection - P300 event related potential and striatal dopamine
    Oliver Pogarell
    Department of Psychiatry, Ludwig Maximilian University of Munich, Germany
    Psychiatry Res 194:212-8. 2011
    ..This association might be of relevance for the interpretation of P300 studies in psychiatric disorders...
  14. ncbi request reprint Auditory cortex and anterior cingulate cortex sources of the early evoked gamma-band response: relationship to task difficulty and mental effort
    Christoph Mulert
    Department of Psychiatry, LMU, Nussbaumstrasse 7, D 80336 Munich, Germany
    Neuropsychologia 45:2294-306. 2007
    ..These findings are in line with a top-down influence of dACC-activity to the auditory association area 22 during the early evoked GBR...
  15. ncbi request reprint Rostral anterior cingulate cortex activity in the theta band predicts response to antidepressive medication
    Christoph Mulert
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Clin EEG Neurosci 38:78-81. 2007
    ..In addition to major differences between responders and nonresponders in the rostral ACC, we have identified a nearby region in the midline orbito-frontal region...
  16. ncbi request reprint Prediction of clinical response to antidepressants in patients with depression: neurophysiology in clinical practice
    Oliver Pogarell
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Clin EEG Neurosci 38:74-7. 2007
    ..This review focuses on recent studies providing evidence for the validity of LD as an indirect serotonergic marker and highlights data on the clinical application in terms of prediction of treatment response in patients with depression...
  17. doi request reprint Avoiding the ballistocardiogram (BCG) artifact of EEG data acquired simultaneously with fMRI by pulse-triggered presentation of stimuli
    Matthias Ertl
    Department of Psychiatry, LMU, Munich, Germany
    J Neurosci Methods 186:231-41. 2010
    ..In combination with an averaged artifact subtraction method signal distortion was reduced at best by 47%...
  18. ncbi request reprint Prediction of treatment response in major depression: integration of concepts
    Christoph Mulert
    Department of Psychiatry, LMU, Munich, Germany
    J Affect Disord 98:215-25. 2007
    ..Here, a high LDAEP is supposed to reflect low central serotonergic activity. We present the first study comparing both approaches in the same group of patients...
  19. doi request reprint Are treatment preferences relevant in response to serotonergic antidepressants and cognitive-behavioral therapy in depressed primary care patients? Results from a randomized controlled trial including a patients' choice arm
    Roland Mergl
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Psychother Psychosom 80:39-47. 2011
    ..We investigated whether better clinical outcome in depressed primary care patients is associated with receiving their preferred treatment...
  20. ncbi request reprint Association of 5-HT1B receptor polymorphisms with the loudness dependence of auditory evoked potentials in a community-based sample of healthy volunteers
    Georg Juckel
    Department of Psychiatry, Ruhr University Bochum, Alexandrinenstrasse 1, 44791 Bochum, Germany
    Am J Med Genet B Neuropsychiatr Genet 147:454-8. 2008
    ....
  21. doi request reprint Is evaluation of humorous stimuli associated with frontal cortex morphology? A pilot study using facial micro-movement analysis and MRI
    Georg Juckel
    Department of Psychiatry, Ruhr University Bochum, Germany
    Cortex 47:569-74. 2011
    ....
  22. ncbi request reprint Loudness dependence of auditory evoked potentials is not associated with polymorphisms or haplotypes in the serotonin transporter gene in a community-based sample of German healthy volunteers
    Georg Juckel
    Department of Psychiatry, Ruhr University Bochum, Germany
    Psychiatry Res 153:183-7. 2007
    ..We speculate that the LD endophenotype depends more on genetic variations in components of the serotonergic system controlling release than on those controlling the uptake mechanism...
  23. doi request reprint Effects of pharmacotherapy and psychotherapy in depressed primary-care patients: a randomized, controlled trial including a patients' choice arm
    Ulrich Hegerl
    Department of Psychiatry, University of Leipzig, Semmelweisstr 10, D 04103 Leipzig, Germany
    Int J Neuropsychopharmacol 13:31-44. 2010
    ..Overall, sertraline is efficacious in primary-care patients with milder forms of depression. The superiority of cognitive-behavioural group therapy over guided self-help groups might partly be explained by 'nocebo' effects of the latter...
  24. ncbi request reprint Sustainable effects on suicidality were found for the Nuremberg alliance against depression
    Ulrich Hegerl
    Department of Psychiatry, University of Leipzig, Semmelweisstr 10, 04103, Leipzig, Germany
    Eur Arch Psychiatry Clin Neurosci 260:401-6. 2010
    ..The four-level intervention concept appears to be cost-effective and is presently implemented in many European regions...
  25. doi request reprint Single-trial coupling of EEG and fMRI reveals the involvement of early anterior cingulate cortex activation in effortful decision making
    Christoph Mulert
    Department of Psychiatry, LMU, Nussbaumstrasse 7, 80336 Munich, Germany
    Neuroimage 42:158-68. 2008
    ..4). These findings suggest a role of early ACC activation in effort-related decision making and provide a direct link between the N1 component and its corresponding BOLD signal...
  26. pmc [I-123] ADAM and SPECT in patients with borderline personality disorder and healthy control subjects
    Walter Koch
    Department of Nuclear Medicine, Ludwig Maximilians University, Munich, Germany
    J Psychiatry Neurosci 32:234-40. 2007
    ..The aim of this study was to investigate serotonin transporter availability in patients with BPD as a marker of the central serotonergic system...
  27. ncbi request reprint Differential prediction of first clinical response to serotonergic and noradrenergic antidepressants using the loudness dependence of auditory evoked potentials in patients with major depressive disorder
    Georg Juckel
    Department of Psychiatry, Ruhr University Bochum, Bochum, Germany
    J Clin Psychiatry 68:1206-12. 2007
    ..The aim of the current randomized prospective study was to investigate whether or not LDAEP also allows the differential prediction of treatment response to serotonergic versus noradrenergic antidepressants...
  28. doi request reprint EEG-vigilance and response to stimulants in paediatric patients with attention deficit/hyperactivity disorder
    Christian Sander
    Department of Psychiatry, University Hospital Leipzig, Leipzig, Germany
    Clin Neurophysiol 121:1511-8. 2010
    ..In a pilot study it was investigated whether assessment of EEG-vigilance is useful for the prediction of treatment outcome in ADHD patients...
  29. ncbi request reprint Allelic variants of the functional promoter polymorphism of the human serotonin transporter gene is associated with auditory cortical stimulus processing
    Jurgen Gallinat
    Department of Psychiatry, Free University of Berlin, Eschenallee 3, 14050 Berlin, Germany
    Neuropsychopharmacology 28:530-2. 2003
    ..The LD may serve as endophenotype in human serotonin research...
  30. ncbi request reprint EEG-vigilance and BOLD effect during simultaneous EEG/fMRI measurement
    Sebastian Olbrich
    Department of Psychiatry, University of Leipzig, Semmelweisstrasse 10, D 04103 Leipzig, Germany
    Neuroimage 45:319-32. 2009
    ..For cognitive fMRI-research it therefore seems important to pay attention to vigilance switches in order to separate vigilance associated BOLD signal changes from those specifically related to cognition...
  31. doi request reprint Beside the Geriatric Depression Scale: the WHO-Five Well-being Index as a valid screening tool for depression in nursing homes
    Antje Kathrin Allgaier
    Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Int J Geriatr Psychiatry 28:1197-204. 2013
    ....
  32. ncbi request reprint Depressive, anxiety, and somatoform disorders in primary care: prevalence and recognition
    Roland Mergl
    Department of Psychiatry, Ludwig Maximilians University Munich, Munich, Germany
    Depress Anxiety 24:185-95. 2007
    ..These results confirm assumptions that the current division between depression and anxiety might be debatable. Validity of screeners tested in our study was not affected by comorbid conditions (e.g., anxiety or somatoform disorders)...
  33. ncbi request reprint Symptom-specific EEG power correlations in patients with obsessive-compulsive disorder
    Oliver Pogarell
    Department of Psychiatry, Division of Clinical Neurophysiology, Ludwig Maximilians University of Munich, Germany
    Int J Psychophysiol 62:87-92. 2006
    ..The opposite correlations of neurophysiological data and clinical features, i.e. obsessions and compulsions, are suggestive of pathophysiological differences based on the presence of the respective cardinal symptoms of OCD...
  34. ncbi request reprint EEG-vigilance differences between patients with borderline personality disorder, patients with obsessive-compulsive disorder and healthy controls
    Ulrich Hegerl
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Eur Arch Psychiatry Clin Neurosci 258:137-43. 2008
    ....
  35. ncbi request reprint Seasonality of suicide attempts: association with gender
    Roland Mergl
    Department of Psychiatry, University of Leipzig, Semmelweisstr 10, 04103, Leipzig, Germany
    Eur Arch Psychiatry Clin Neurosci 260:393-400. 2010
    ..Whereas seasonality was absent in male suicide attempters, the frequency of low-risk suicide attempts in females was 13.1% lower than expected in the spring...
  36. doi request reprint Diagnostic usefulness of cognitive auditory event-related p300 subcomponents in patients with Alzheimers disease?
    Georg Juckel
    Department of Psychiatry, Ruhr University Bochum, Germany
    J Clin Neurophysiol 25:147-52. 2008
    ....
  37. ncbi request reprint Serotonergic dysfunction in schizophrenia assessed by the loudness dependence measure of primary auditory cortex evoked activity
    Georg Juckel
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Schizophr Res 64:115-24. 2003
    ..These results suggest that the loudness dependence of primary auditory cortex evoked activity is well suitable to assess serotonergic dysfunction in schizophrenia...
  38. ncbi request reprint Elevated brain serotonin transporter availability in patients with obsessive-compulsive disorder
    Oliver Pogarell
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Biol Psychiatry 54:1406-13. 2003
    ..The aim of this study was to investigate the serotonin transporter availability in patients with OCD as an in vivo marker of the central serotonergic system...
  39. ncbi request reprint Onset of depressive episodes is faster in patients with bipolar versus unipolar depressive disorder: evidence from a retrospective comparative study
    Ulrich Hegerl
    Department of Psychiatry, University of Leipzig, Johannisallee 20, D 04317 Leipzig, Germany
    J Clin Psychiatry 69:1075-80. 2008
    ....
  40. doi request reprint Can effects of antidepressants in patients with mild depression be considered as clinically significant?
    Ulrich Hegerl
    Department of Psychiatry, University of Leipzig, Semmelweisstr 10, D 04103 Leipzig, Germany
    J Affect Disord 138:183-91. 2012
    ..A mean difference of at least 3 points on the Hamilton Depression Rating Scale (HAMD-17) between active treatment and placebo has been proposed as cut-off score for clinical significance in antidepressant trials...
  41. ncbi request reprint White matter alterations in schizophrenic patients with pronounced negative symptomatology and with positive family history for schizophrenia
    Thomas Zetzsche
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstr 7, 80336, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 258:278-84. 2008
    ..The aim of our analysis was to investigate potential changes of white matter in schizophrenic patients compared to controls, and the relationship to clinical characteristics...
  42. ncbi request reprint Event-related potentials in psychiatry
    Oliver Pogarell
    Department of Psychiatry, Division of Clinical Neurophysiology, Ludwig Maximilians University of Munich, Germany
    Clin EEG Neurosci 38:25-34. 2007
    ..Among these techniques, event-related potentials (ERPs) are of major interest in psychiatry, particularly since these tools can indicate cortical neuronal dysfunctions, which play a major role in various neuropsychiatric disorders...
  43. ncbi request reprint Influence of anxiety on electrophysiological correlates of response inhibition capacities in alcoholism
    Susanne Karch
    Dept of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Clin EEG Neurosci 38:89-95. 2007
    ..The results emphasize the importance of monitoring trait anxiety in studies regarding cognitive functions in subjects with alcohol use disorder...
  44. ncbi request reprint How effective is advanced training concerning depression and suicidality among the elderly? Results of a pilot study
    Anja Ziervogel
    Department of Psychiatry, German Research Net on Depression and Suicidality, University of Munich, Munich, Germany
    Arch Suicide Res 9:11-7. 2005
    ..Attitude towards "suicide in old age" also changed significantly. The training program was effective in improving knowledge and attitudes of geriatric caregivers concerning depression and suicidality...
  45. ncbi request reprint Simultaneous EEG-fMRI: perspectives in psychiatry
    Christoph Mulert
    Department of Psychiatry, University of Munich, Germany
    Clin EEG Neurosci 39:61-4. 2008
    ..EEG-fMRI may prove to be crucial in providing much deeper understanding of brain activity over the next decades. This review summarizes the basic physiology, methodological issues and interesting applications in psychiatry...
  46. pmc Optimizing suicide prevention programs and their implementation in Europe (OSPI Europe): an evidence-based multi-level approach
    Ulrich Hegerl
    University of Leipzig, Department of Psychiatry, Germany
    BMC Public Health 9:428. 2009
    ..However, the evidence for effective preventive strategies is scarce. The protocol of a European research project to develop an optimized evidence based program for suicide prevention is presented...
  47. doi request reprint Cholinergic receptor subtypes and their role in cognition, emotion, and vigilance control: an overview of preclinical and clinical findings
    Susanne Graef
    Department of Psychiatry, University of Leipzig, Semmelweisstr 10, 04103 Leipzig, Germany
    Psychopharmacology (Berl) 215:205-29. 2011
    ..The cholinergic system has long been linked to cognitive processes. Two main classes of acetylcholine (ACh) receptors exist in the human brain, namely muscarinic and nicotinic receptors, of which several subtypes occur...
  48. ncbi request reprint Facial expressions and personality: a kinematical investigation during an emotion induction experiment
    Roland Mergl
    Department of Psychiatry, Ludwig Maximilians University Munich, Nussbaumstrasse 7, DE 80336 Munich, Germany
    Neuropsychobiology 54:114-9. 2006
    ....
  49. ncbi request reprint Screening for depression in the older long-term unemployed
    Iris Liwowsky
    Dept of Psychiatry, Ludwig Maximilian University Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    Soc Psychiatry Psychiatr Epidemiol 44:622-7. 2009
    ..Screening for depression could be a first step to increasing treatment rates within this high-risk group. Therefore, the WHO-5 Well-Being Index was tested for its validity in unemployment offices...
  50. ncbi request reprint Screening for depression in primary care: will one or two items suffice?
    Verena Henkel
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 254:215-23. 2004
    ....
  51. ncbi request reprint Differential effects of reboxetine and citalopram on hand-motor function in patients suffering from major depression
    Ulrich Hegerl
    Laboratory of Clinical Neurophysiology, Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Nussbaumstr 7, 80336, Munich, Germany
    Psychopharmacology (Berl) 178:58-66. 2005
    ..However, the effects of antidepressants on motor function in depression have rarely been analyzed systematically. Computerized methods allow the objective registration of drug-induced motor dysfunction and were applied in this study...
  52. ncbi request reprint P300 subcomponents and clinical symptoms in schizophrenia
    Thomas Frodl
    Section of Clinical Neurophysiology, Department of Psychiatry of the Ludwig Maximilians University, Nussbaumstr 7, 80336, Munich, Germany
    Int J Psychophysiol 43:237-46. 2002
    ..On the other hand, diminished P300 with illness duration in the group of patients with later age of onset supports an underlying neurodegenerative progressive process in this subgroup of patients...
  53. ncbi request reprint Serotonin and dopamine transporter availabilities correlate with the loudness dependence of auditory evoked potentials in patients with obsessive-compulsive disorder
    Oliver Pogarell
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Neuropsychopharmacology 29:1910-7. 2004
    ....
  54. ncbi request reprint Should combined pharmaco- and psychotherapy be offered to depressed patients? A qualitative review of randomized clinical trials from the 1990s
    Ulrich Hegerl
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Nussbaumstr 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 254:99-107. 2004
    ..Compared to psychotherapy alone, severely depressed MDD patients profit more and faster when treated with combined psycho-pharmacotherapy...
  55. ncbi request reprint Identification of a naturally occurring polymorphism in the promoter region of the norepinephrine transporter and analysis in major depression
    Peter Zill
    Psychiatric Hospital of the Ludwig Maximilians University Munich, Nussbaumstr 7, D 80336 Munich, Germany
    Neuropsychopharmacology 26:489-93. 2002
    ..Our results suggest that the investigated polymorphisms are not major susceptibility factors in the etiology of major depression...
  56. ncbi request reprint Use of brief depression screening tools in primary care: consideration of heterogeneity in performance in different patient groups
    Verena Henkel
    Department of Psychiatry, Ludwig Maximilians University Munich, Nussbaumstr 7, D 80336 Munich, Germany
    Gen Hosp Psychiatry 26:190-8. 2004
    ..This should be considered if routine depression screening should be widely introduced. Of course, the benefit of routine screening also depends on efforts made for treatment and monitoring of patients in whom depression was diagnosed...
  57. ncbi request reprint [Improvement of knowledge and attitudes towards depression and suicidality in geriatric caregivers: evaluation of an advanced training program]
    Antje Kathrin Allgaier
    Deutsches Bündnis gegen Depression eV, Klinik und Poliklinik fur Psychiatrie der Universitat Leipzig, Leipzig, Germany
    Z Gerontol Geriatr 42:228-35. 2009
    ..Especially pronounced effects were found for the attitudes towards depression and suicidality as well as treatability with antidepressants. These changes were stable, as indicated by the follow-up evaluation...
  58. ncbi request reprint Integration of fMRI and simultaneous EEG: towards a comprehensive understanding of localization and time-course of brain activity in target detection
    Christoph Mulert
    Department of Psychiatry, LMU, Nussbaumstrasse 7, 80336 Munich, Germany
    Neuroimage 22:83-94. 2004
    ..The results suggest that the combination of EEG and fMRI permits an improved understanding of the spatiotemporal dynamics of brain activity...
  59. ncbi request reprint The gamma amino butyric acid (GABA) receptor alpha-3 subunit gene polymorphism in unipolar depressive disorder: a genetic association study
    Verena Henkel
    Department of Psychiatry, Ludwig Maximilians University Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    Am J Med Genet B Neuropsychiatr Genet 126:82-7. 2004
    ....
  60. ncbi request reprint Investigation of a possible diencephalic pathology in schizophrenia
    Eva M Meisenzahl
    Department of Psychiatry, Ludwig Maximilians Universitat, Nussbaumstr 7, 80 339 Munich, Germany
    Psychiatry Res 115:127-35. 2002
    ..Interestingly, the subgroup of healthy controls without AI also had larger third ventricles. The absence of AI may represent another early developmental marker of cerebral malformation in a clinical subgroup of schizophrenic patients...
  61. ncbi request reprint EEG abnormalities associated with antipsychotics: a comparison of quetiapine, olanzapine, haloperidol and healthy subjects
    Benedikt L Amann
    Department of Psychiatry, Section of Clinical Neurophysiology, University of Munich, Germany
    Hum Psychopharmacol 18:641-6. 2003
    ..To our knowledge, this is the first electrophysiological investigation comparing the new atypical antipsychotics quetiapine, haloperidol, olanzapine with healthy subjects...
  62. ncbi request reprint Value of event-related P300 subcomponents in the clinical diagnosis of mild cognitive impairment and Alzheimer's Disease
    Thomas Frodl
    Department of Psychiatry, Ludwig Maximilians University Munich, Germany
    Psychophysiology 39:175-81. 2002
    ..Similar results were found using Pz amplitudes as well as Fz latencies. Our data suggest that TB-P300 amplitudes and TS-P300 latencies may be an accurate clinically available, nonexpensive, noninvasive, and reliable marker for AD...
  63. ncbi request reprint The evaluation of suicide prevention activities: state of the art
    David Althaus
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    World J Biol Psychiatry 4:156-65. 2003
    ..The authors therefore argue that a combination of different strategies in a multi-level approach might prove to be the most effective...
  64. ncbi request reprint Effects of sertraline on kinematic aspects of hand movements in patients with obsessive-compulsive disorder
    Roland Mergl
    Department of Psychiatry, Laboratory of Clinical Neurophysiology, Ludwig Maximilians Universitat Munchen, Nussbaumstrasse 7, 80336, Munchen, Germany
    Psychopharmacology (Berl) 171:179-85. 2004
    ..Movement disorders such as disturbances of fine motor co-ordination are a frequent phenomenon in patients with obsessive-compulsive disorder (OCD)...
  65. pmc Identifying depression in primary care: a comparison of different methods in a prospective cohort study
    Verena Henkel
    Department of Psychiatry, Ludwig Maximilians University Munich, Nussbaumstr 7, D 80336 Munich, Germany
    BMJ 326:200-1. 2003
  66. ncbi request reprint [Media coverage on suicide in Nuremberg's daily papers--frequency and form of the reporting before and during media-intervention with guidelines]
    Rita Schäfer
    Klinik für Psychiatrie und Psychotherapie der Ludwig Maximilians Universität München
    Psychiatr Prax 33:132-7. 2006
    ..The effects of this mediaguide on the reporting are being evaluated...
  67. ncbi request reprint Can a subgroup of OCD patients with motor abnormalities and poor therapeutic response be identified?
    Roland Mergl
    Laboratory of Clinical Neurophysiology, Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Nussbaumstr 7, 80336 Munich, Bavaria, Germany
    Psychopharmacology (Berl) 179:826-37. 2005
    ..In a subgroup of patients with obsessive-compulsive disorder (OCD), motor soft signs, tics and other movement disorders can be observed, indicating a special pathogenetic involvement of basal ganglia...
  68. ncbi request reprint Evidence for a close relationship between conscious effort and anterior cingulate cortex activity
    Christoph Mulert
    Department of Psychiatry, Nussbaumstrasse 7, LMU, Munich 80336 München, Germany
    Int J Psychophysiol 56:65-80. 2005
    ..These results provide direct evidence for a close relationship between conscious effort and ACC activity and suggest the usefulness of the applied effort-self-rating...
  69. ncbi request reprint SERT and DAT availabilities under citalopram treatment in obsessive-compulsive disorder (OCD)
    Oliver Pogarell
    Department of Psychiatry, Section of Clinical Neurophysiology, Ludwig Maximilians University of Munich, Nussbaumstr 7, D 80336 Munich, Germany
    Eur Neuropsychopharmacol 15:521-4. 2005
    ..The data point at a citalopram induced modulation of both serotonergic and dopaminergic activity and support the notion of functional interactions of monoaminergic systems in the human brain...
  70. ncbi request reprint [Whether pyromaniac, kleptomaniac, pathological gambler or messy--the impulse is out of control]
    Ulrich Hegerl
    Psychiatrische Klinik der LMU München
    MMW Fortschr Med 146:33-4. 2004
  71. ncbi request reprint Depression with atypical features in a sample of primary care outpatients: prevalence, specific characteristics and consequences
    Verena Henkel
    Department of Psychiatry, Ludwig Maximilians University Munich, Nussbaumstr 7, D 80336 Munich, Germany
    J Affect Disord 83:237-42. 2004
    ....
  72. ncbi request reprint P300 subcomponents in obsessive-compulsive disorder
    Paraskevi Mavrogiorgou
    Department of Psychiatry, Section of Clinical Neurophysiology and Outpatient Clinic for Obsessive Compulsive Disorder, Ludwig Maximilians University Munich, Germany
    J Psychiatr Res 36:399-406. 2002
    ....
  73. ncbi request reprint Sound level dependence of the primary auditory cortex: Simultaneous measurement with 61-channel EEG and fMRI
    Christoph Mulert
    Department of Psychiatry, LMU, Munich, Germany
    Neuroimage 28:49-58. 2005
    ..In addition, the correspondence of the ERP-based data and the fMRI results further supports the validity of the ERP localization approach...
  74. ncbi request reprint One followed by many?-Long-term effects of a celebrity suicide on the number of suicidal acts on the German railway net
    Ulrich Hegerl
    Department of Psychiatry, University of Leipzig, Semmelweisstr 10, D 04103 Leipzig, Germany
    J Affect Disord 146:39-44. 2013
    ..Main aims of the present study were to analyze long-term effects of this incidence and to compare them with overall national suicide data, as well as to investigate possible "anniversary effects"...
  75. ncbi request reprint Treatment of depression with atypical features: a meta-analytic approach
    Verena Henkel
    Department of Psychiatry, Laboratory of Clinical Neurophysiology, Ludwig Maximilians University Munich, Nussbaumstr 7, D 80336 Munich, Germany
    Psychiatry Res 141:89-101. 2006
    ..The available data are insufficient for a direct comparison between MAOIs and selective serotonin reuptake inhibitors...
  76. ncbi request reprint A Ser9Gly polymorphism in the dopamine D3 receptor gene (DRD3) and event-related P300 potentials
    Christoph Mulert
    Department of Psychiatry, University of Munich, LMU, Munich, Germany
    Neuropsychopharmacology 31:1335-44. 2006
    ..Further studies should address the direct role of the DRD3 Ser9Gly polymorphism in attenuated P300 amplitudes in psychiatric disorders like schizophrenia or alcoholism...
  77. ncbi request reprint Event related potentials and fMRI in neuropsychopharmacology
    Oliver Pogarell
    Department of Psychiatry, Division of Clinical Neurophysiology, Ludwig Maximilians University of Munich, Munich, Germany
    Clin EEG Neurosci 37:99-107. 2006
    ..Owing to important recent developments in the field of brain functional diagnostics the combination of neurophysiological techniques and functional magnetic resonance imaging (fMRI) will be included...
  78. doi request reprint Focus on mental health care reforms in Europe: the European alliance against depression: a multilevel approach to the prevention of suicidal behavior
    Ulrich Hegerl
    Department of Psychiatry, University of Leipzig, Semmelweisstrasse10, 04103 Leipzig, Germany
    Psychiatr Serv 60:596-9. 2009
    ..Several countries have expanded their original model program into other regions or nationwide...
  79. doi request reprint Mania and attention-deficit/hyperactivity disorder: common symptomatology, common pathophysiology and common treatment?
    Ulrich Hegerl
    Department of Psychiatry, University of Leipzig, Semmelweisstrasse 10, Leipzig, Germany
    Curr Opin Psychiatry 23:1-7. 2010
    ..This raises the question concerning common neurobiological pathomechanisms and concerning common treatments...
  80. ncbi request reprint Striatal dopamine release after prefrontal repetitive transcranial magnetic stimulation in major depression: preliminary results of a dynamic [123I] IBZM SPECT study
    Oliver Pogarell
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstr 7, D 80336 Munich, Germany
    J Psychiatr Res 40:307-14. 2006
    ..In future, this approach can be used to differentiate specific and non-specific reward-related effects of rTMS on dopaminergic neurotransmission...
  81. ncbi request reprint The German Research Network on Depression and Suicidality
    Tim Pfeiffer
    Psychiatric Hospital at the University of Munich, Munich, Germany
    Arch Suicide Res 9:3-9. 2005
    ..Since then more than 20 individual projects have been initiated. Meanwhile more and more results of these projects become available and increasing efforts are undertaken to transfer these results into elements of standard health care...
  82. ncbi request reprint Screening for depression in adult acne vulgaris patients: tools for the dermatologist
    Verena Henkel
    Department of Psychiatry, Ludwig Maximilians University Munich, Munich, Germany
    J Cosmet Dermatol 1:202-7. 2002
    ..If psychiatric co-morbidity is unrecognized, undetected and untreated, the consequences may be fatal. Acne is the most common skin disorder of the second and third decades of life. Acne and its treatments may cause depression...
  83. doi request reprint Association of functional polymorphisms in NOS1 and NOS3 with loudness dependence of auditory evoked potentials
    Wolfram Kawohl
    Research Group Clinical and Experimental Psychopathology, Psychiatric University Hospital Zurich, Zurich, Switzerland
    Int J Neuropsychopharmacol 11:477-83. 2008
    ..Further studies are needed to fully clarify the relationship between nitrinergic transmission, LDAEP and complex disorders such as schizophrenia and affective disorders...
  84. ncbi request reprint [The German Research Network on depression and suicidality]
    Tim Pfeiffer-Gerschel
    Klinik und Poliklinik für Psychiatrie und Psychotherapie der Ludwig Maximilians Universität, Munchen
    Med Klin (Munich) 101:505-8. 2006
    ..Since then, more than 20 individual projects have been initiated. Meanwhile, more and more results of these projects become available and increasing efforts are undertaken to transfer these results into elements of standard health care...
  85. ncbi request reprint Loudness dependence of the auditory evoked N1/P2 component as an indicator of serotonergic dysfunction in patients with schizophrenia--a replication study
    Georg Juckel
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Germany
    Psychiatry Res 158:79-82. 2008
    ..Thus, we were able again to demonstrate electrophysiological evidence for an upregulated serotonergic system in schizophrenia...
  86. ncbi request reprint [Speed of onset of depressive episodes: a clinical criterion helpful for separating uni- from bipolar affective disorders]
    Ulrich Hegerl
    Klinik und Poliklinik fur Psychiatrie, Universitatsklinikum Leipzig
    Neuropsychiatr 22:92-9. 2008
    ..The aim of this study was to analyze speed of onset of depressive episodes in patients with unipolar depression (UD) and bipolar affective disorders (BD)...
  87. ncbi request reprint Suicide attempts: results and experiences from the German Competency Network on Depression
    Hartmut Lehfeld
    Klinik fur Psychiatrie und Psychotherapie, Klinikum Nürnberg, Deutschland
    Adv Psychosom Med 26:137-43. 2004
  88. ncbi request reprint Electroencephalographic abnormalities associated with antidepressant treatment: a comparison of mirtazapine, venlafaxine, citalopram, reboxetine, and amitriptyline
    Andrea Sterr
    J Clin Psychiatry 67:325-6. 2006
  89. ncbi request reprint Suicide prevention strategies: a systematic review
    J John Mann
    New York State Psychiatric Institute, Division of Neuroscience, New York, NY 10032, USA
    JAMA 294:2064-74. 2005
    ..Some developed nations have implemented national suicide prevention plans. Although these plans generally propose multiple interventions, their effectiveness is rarely evaluated...
  90. ncbi request reprint Hand-motor dysfunction in depression: characteristics and pharmacological effects
    Roland Mergl
    Dept of Psychiatry, University Leipzig, Germany
    Clin EEG Neurosci 38:82-8. 2007
    ..II: Computer-aided analysis of hand movements is a sensitive tool for the registration of differential pharmaceutical effects on hand-motor function in depression...
  91. ncbi request reprint [The "European Alliance Against Depression". An European network targeting at effective care in community-based services for persons suffering from depressive disorders]
    Tim Pfeiffer-Gerschel
    Klinik und Poliklinik für Psychiatrie und Psychotherapie der LMU Mümchen
    Neuropsychiatr 21:51-8. 2007
    ....
  92. ncbi request reprint [Kinematic movement analyses and their application in psychiatry]
    Georg Juckel
    Klinik fur Psychiatrie und Psychotherapie, Charite, Campus Mitte Berlin
    Psychiatr Prax 32:S31-7. 2005
    ..Thus, these methods are well suitable for relating them to other neurobiological parameters in order to contribute to the pathophysiological understanding of psycho-motor symptoms in psychiatric patients...
  93. ncbi request reprint [From the Nuremberg Alliance Against Depression to a European network (EAAD)--extending community-based awareness-campaigns on national and European level]
    Ulrich Hegerl
    Klinik und Poliklinik fur Psychiatrie der Universitat Leipzig, Johannesallee 20, 04317 Leipzig
    Psychiatr Prax 34:S261-5. 2007
    ..On international level the European Alliance Against Depression (EAAD) was established 2004. Funded by the European Commission the four-level-programme is implemented in 17 European countries...