U Hegerl

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. doi request reprint Alliances against depression - A community based approach to target depression and to prevent suicidal behaviour
    Ulrich Hegerl
    Department of Psychiatry, University of Leipzig Stiftung Deutsche Depressionshilfe, Germany Electronic address
    Neurosci Biobehav Rev 37:2404-9. 2013
  2. pmc Why has the continuous decline in German suicide rates stopped in 2007?
    Ulrich Hegerl
    Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany
    PLoS ONE 8:e71589. 2013
  3. pmc Time perception at different EEG-vigilance levels
    Juliane Minkwitz
    Department of Psychiatry and Psychotherapy, University of Leipzig, Semmelweisstr, 10, 04103 Leipzig, Germany
    Behav Brain Funct 8:50. 2012
  4. pmc Developing social capital in implementing a complex intervention: a process evaluation of the early implementation of a suicide prevention intervention in four European countries
    Fiona M Harris
    Nursing, Midwifery and Allied Health Professions Research Unit, Iris Murdoch Building, University of Stirling, Stirling FK9 4LA, UK
    BMC Public Health 13:158. 2013
  5. doi request reprint Fast versus slow onset of depressive episodes: a clinical criterion for subtyping patients with major depression
    U Hegerl
    Department of Psychiatry, University of Leipzig, Semmelweisstr 10, 04103 Leipzig, Germany
    Eur Psychiatry 28:288-92. 2013
  6. pmc Methylphenidate in mania project (MEMAP): study protocol of an international randomised double-blind placebo-controlled study on the initial treatment of acute mania with methylphenidate
    Michael Kluge
    Department of Psychiatry and Psychotherapy, University of Leipzig, Semmelweisstrasse 10, 04103, Leipzig, Germany
    BMC Psychiatry 13:71. 2013
  7. doi request reprint One followed by many?-Long-term effects of a celebrity suicide on the number of suicidal acts on the German railway net
    Ulrich Hegerl
    Department of Psychiatry, University of Leipzig, Semmelweisstr 10, D 04103 Leipzig, Germany
    J Affect Disord 146:39-44. 2013
  8. doi request reprint Does pain improve earlier than mood in depressed patients with painful physical symptoms treated with duloxetine?
    U Hegerl
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Pharmacopsychiatry 45:114-8. 2012
  9. doi request reprint Can effects of antidepressants in patients with mild depression be considered as clinically significant?
    Ulrich Hegerl
    Department of Psychiatry, University of Leipzig, Semmelweisstr 10, D 04103 Leipzig, Germany
    J Affect Disord 138:183-91. 2012
  10. pmc Prestimulus vigilance predicts response speed in an easy visual discrimination task
    Juliane Minkwitz
    Department of Psychiatry and Psychotherapy, University of Leipzig, Semmelweisstr, 10, 04103 Leipzig, Germany
    Behav Brain Funct 7:31. 2011

Collaborators

Detail Information

Publications144 found, 100 shown here

  1. doi request reprint Alliances against depression - A community based approach to target depression and to prevent suicidal behaviour
    Ulrich Hegerl
    Department of Psychiatry, University of Leipzig Stiftung Deutsche Depressionshilfe, Germany Electronic address
    Neurosci Biobehav Rev 37:2404-9. 2013
    ..Within the suicide prevention project OSPI-Europe, the four-level-approach was optimized and further implemented and evaluated in different European regions...
  2. pmc Why has the continuous decline in German suicide rates stopped in 2007?
    Ulrich Hegerl
    Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany
    PLoS ONE 8:e71589. 2013
    ....
  3. pmc Time perception at different EEG-vigilance levels
    Juliane Minkwitz
    Department of Psychiatry and Psychotherapy, University of Leipzig, Semmelweisstr, 10, 04103 Leipzig, Germany
    Behav Brain Funct 8:50. 2012
    ..Thus, we hypothesised that the re-tapping interval length and the accuracy of reproduction performance would vary depending on the state of vigilance determined by EEG...
  4. pmc Developing social capital in implementing a complex intervention: a process evaluation of the early implementation of a suicide prevention intervention in four European countries
    Fiona M Harris
    Nursing, Midwifery and Allied Health Professions Research Unit, Iris Murdoch Building, University of Stirling, Stirling FK9 4LA, UK
    BMC Public Health 13:158. 2013
    ..This paper reports on a process evaluation of the early implementation stage of an optimised suicide prevention programme (OSPI-Europe) implemented in four European countries...
  5. doi request reprint Fast versus slow onset of depressive episodes: a clinical criterion for subtyping patients with major depression
    U Hegerl
    Department of Psychiatry, University of Leipzig, Semmelweisstr 10, 04103 Leipzig, Germany
    Eur Psychiatry 28:288-92. 2013
    ..Thus, we aimed to explore whether patients with fast onset of the full-blown depressive symptomatology (≤7 days) differ from those with slow onset (>7 days) with regard to demographic and clinical aspects...
  6. pmc Methylphenidate in mania project (MEMAP): study protocol of an international randomised double-blind placebo-controlled study on the initial treatment of acute mania with methylphenidate
    Michael Kluge
    Department of Psychiatry and Psychotherapy, University of Leipzig, Semmelweisstrasse 10, 04103, Leipzig, Germany
    BMC Psychiatry 13:71. 2013
    ..We present here the study protocol of a trial intended to study the efficacy and safety of methylphenidate in the initial treatment of acute mania...
  7. doi request reprint One followed by many?-Long-term effects of a celebrity suicide on the number of suicidal acts on the German railway net
    Ulrich Hegerl
    Department of Psychiatry, University of Leipzig, Semmelweisstr 10, D 04103 Leipzig, Germany
    J Affect Disord 146:39-44. 2013
    ..Main aims of the present study were to analyze long-term effects of this incidence and to compare them with overall national suicide data, as well as to investigate possible "anniversary effects"...
  8. doi request reprint Does pain improve earlier than mood in depressed patients with painful physical symptoms treated with duloxetine?
    U Hegerl
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Pharmacopsychiatry 45:114-8. 2012
    ..We investigated whether under treatment with duloxetine pain improves earlier than mood...
  9. doi request reprint Can effects of antidepressants in patients with mild depression be considered as clinically significant?
    Ulrich Hegerl
    Department of Psychiatry, University of Leipzig, Semmelweisstr 10, D 04103 Leipzig, Germany
    J Affect Disord 138:183-91. 2012
    ..A mean difference of at least 3 points on the Hamilton Depression Rating Scale (HAMD-17) between active treatment and placebo has been proposed as cut-off score for clinical significance in antidepressant trials...
  10. pmc Prestimulus vigilance predicts response speed in an easy visual discrimination task
    Juliane Minkwitz
    Department of Psychiatry and Psychotherapy, University of Leipzig, Semmelweisstr, 10, 04103 Leipzig, Germany
    Behav Brain Funct 7:31. 2011
    ..We hypothesised that a low EEG-vigilance state immediately before a reaction task would entail a longer RT. Shorter RTs were expected for a high EEG-vigilance state...
  11. pmc Drug suicide: a sex-equal cause of death in 16 European countries
    Airi Varnik
    Estonian Swedish Mental Health and Suicidology Institute Estonian Centre of Behavioural and Health Sciences, Oie 39, Tallinn 11615, Estonia
    BMC Public Health 11:61. 2011
    ....
  12. pmc Early reduction in painful physical symptoms is associated with improvements in long-term depression outcomes in patients treated with duloxetine
    Edith Schneider
    Lilly Deutschland GmbH, Medical Department, Bad Homburg, Germany
    BMC Psychiatry 11:150. 2011
    ..To investigate the association of the change of painful physical symptoms (PPS) after 4 weeks, with the 6-month treatment outcomes of depressive symptoms in patients treated with duloxetine in clinical practice...
  13. doi request reprint Are antidepressants useful in the treatment of minor depression: a critical update of the current literature
    Ulrich Hegerl
    Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany
    Curr Opin Psychiatry 25:1-6. 2012
    ....
  14. doi request reprint Mania and attention-deficit/hyperactivity disorder: common symptomatology, common pathophysiology and common treatment?
    Ulrich Hegerl
    Department of Psychiatry, University of Leipzig, Semmelweisstrasse 10, Leipzig, Germany
    Curr Opin Psychiatry 23:1-7. 2010
    ..This raises the question concerning common neurobiological pathomechanisms and concerning common treatments...
  15. doi request reprint The clinical significance of antidepressant treatment effects cannot be derived from placebo-verum response differences
    U Hegerl
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    J Psychopharmacol 24:445-8. 2010
    ..Eight arguments are presented indicating that using this definition as a criterion for assessing the clinical utility of antidepressants in daily practice would risk erroneously discarding treatments with a clear benefit for patients...
  16. doi request reprint Sustainable effects on suicidality were found for the Nuremberg alliance against depression
    Ulrich Hegerl
    Department of Psychiatry, University of Leipzig, Semmelweisstr 10, 04103, Leipzig, Germany
    Eur Arch Psychiatry Clin Neurosci 260:401-6. 2010
    ..The four-level intervention concept appears to be cost-effective and is presently implemented in many European regions...
  17. pmc Optimizing suicide prevention programs and their implementation in Europe (OSPI Europe): an evidence-based multi-level approach
    Ulrich Hegerl
    University of Leipzig, Department of Psychiatry, Germany
    BMC Public Health 9:428. 2009
    ..However, the evidence for effective preventive strategies is scarce. The protocol of a European research project to develop an optimized evidence based program for suicide prevention is presented...
  18. doi request reprint [Subdiagnostic depression. Are there treatments with clinically relevant effects?]
    U Hegerl
    Klinik und Poliklinik fur Psychiatrie, Universitatsklinikum Leipzig AoR, Semmelweis Strasse 10, 04103, Leipzig
    Nervenarzt 80:532-4, 536-9. 2009
    ..Due to lacking clinical evidence, aspects of a pragmatic therapeutic approach in those patients are presented...
  19. doi request reprint Are psychostimulants a treatment option in mania?
    U Hegerl
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Pharmacopsychiatry 42:169-74. 2009
    ..g., sleep spindles in EEG) under resting conditions with low external stimulation. The "paradoxical" antimanic effect of psychostimulants possibly results from their vigilance stabilizing properties...
  20. doi request reprint Focus on mental health care reforms in Europe: the European alliance against depression: a multilevel approach to the prevention of suicidal behavior
    Ulrich Hegerl
    Department of Psychiatry, University of Leipzig, Semmelweisstrasse10, 04103 Leipzig, Germany
    Psychiatr Serv 60:596-9. 2009
    ..Several countries have expanded their original model program into other regions or nationwide...
  21. ncbi request reprint Onset of depressive episodes is faster in patients with bipolar versus unipolar depressive disorder: evidence from a retrospective comparative study
    Ulrich Hegerl
    Department of Psychiatry, University of Leipzig, Johannisallee 20, D 04317 Leipzig, Germany
    J Clin Psychiatry 69:1075-80. 2008
    ....
  22. doi request reprint [Manic behavior as an autoregulatory attempt to stabilize vigilance]
    U Hegerl
    Klinik und Poliklinik fur Psychiatrie, Universitatsklinikum Leipzig, AöR, Semmelweissstrasse 10, 04107, Leipzig, Germany
    Nervenarzt 79:1283-4, 1286-90. 2008
    ..They are well proven for ADHD and have repeatedly been shown to have a paradoxical effect in manic patients. The proposed concept opens new approaches for the treatment of acute mania...
  23. ncbi request reprint EEG-vigilance differences between patients with borderline personality disorder, patients with obsessive-compulsive disorder and healthy controls
    Ulrich Hegerl
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Eur Arch Psychiatry Clin Neurosci 258:137-43. 2008
    ....
  24. ncbi request reprint The 'European Alliance Against Depression (EAAD)': a multifaceted, community-based action programme against depression and suicidality
    Ulrich Hegerl
    Klinik und Poliklinik fur Psychiatrie, Universitat Leipzig, Leipzig, Germany
    World J Biol Psychiatry 9:51-8. 2008
    ..EAAD is mentioned by the European commission as a best practice example within the Green Paper 'Improving the mental health of the population: Towards a strategy on mental health for the European Union' (European Commission 2005)...
  25. ncbi request reprint [From the Nuremberg Alliance Against Depression to a European network (EAAD)--extending community-based awareness-campaigns on national and European level]
    Ulrich Hegerl
    Klinik und Poliklinik fur Psychiatrie der Universitat Leipzig, Johannesallee 20, 04317 Leipzig
    Psychiatr Prax 34:S261-5. 2007
    ..On international level the European Alliance Against Depression (EAAD) was established 2004. Funded by the European Commission the four-level-programme is implemented in 17 European countries...
  26. ncbi request reprint [Early detection of depressive illnesses]
    Ulrich Hegerl
    Klinik und Poliklinik fur Psychiatrie, Universitatsklinikum Leipzig
    MMW Fortschr Med 149:27-9, 31. 2007
    ..psychiatriekonsil.de) available to physicians, psychotherapists and pharmacists, which provides advice, free of charge and anonymously, to all those seeking support on depressive or other psychiatric illnesses...
  27. doi request reprint Effects of pharmacotherapy and psychotherapy in depressed primary-care patients: a randomized, controlled trial including a patients' choice arm
    Ulrich Hegerl
    Department of Psychiatry, University of Leipzig, Semmelweisstr 10, D 04103 Leipzig, Germany
    Int J Neuropsychopharmacol 13:31-44. 2010
    ..Overall, sertraline is efficacious in primary-care patients with milder forms of depression. The superiority of cognitive-behavioural group therapy over guided self-help groups might partly be explained by 'nocebo' effects of the latter...
  28. ncbi request reprint [Speed of onset of depressive episodes: a clinical criterion helpful for separating uni- from bipolar affective disorders]
    Ulrich Hegerl
    Klinik und Poliklinik fur Psychiatrie, Universitatsklinikum Leipzig
    Neuropsychiatr 22:92-9. 2008
    ..The aim of this study was to analyze speed of onset of depressive episodes in patients with unipolar depression (UD) and bipolar affective disorders (BD)...
  29. ncbi request reprint Digitized analysis of abnormal hand-motor performance in schizophrenic patients
    P Tigges
    Department of Psychiatry, Ludwig Maximilians University Munich, Clinical Neurophysiology Section, Nussbaumstrasse 7, D 80336, Munich, Germany
    Schizophr Res 45:133-43. 2000
    ..Our findings show NSS in schizophrenic patients, independently of neuroleptics. Further, the hypothesis of lateralization of cerebral structures generating NSS towards the right hemisphere in schizophrenia is supported...
  30. ncbi request reprint The loudness dependency of the auditory evoked N1/P2-component as a predictor of the acute SSRI response in depression
    J Gallinat
    Department of Psychiatry, Free University Berlin, Germany
    Psychopharmacology (Berl) 148:404-11. 2000
    ..In animal and human data there is a growing amount of evidence that a strong loudness dependency of late auditory evoked potentials (LDAEP) is an indicator of low serotonergic activity and vice versa...
  31. ncbi request reprint Loudness dependence of auditory evoked potentials in obsessive-compulsive disorder: a pilot study
    M T Carrillo-de-la-Peña
    Department of Psychiatry, Section of Clinical Neurophysiology and Outpatient Clinic for Obsessive Compulsive Disorder, Ludwig Maximilians Universitat, Munich, Germany
    Psychiatry Res 93:209-16. 2000
    ..These findings do not support the hypothesis of a serotonergic dysfunction in OCD patients...
  32. pmc Kinematical analysis of emotionally induced facial expressions: a novel tool to investigate hypomimia in patients suffering from depression
    R Mergl
    Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Nussbaumstrasse 7, D 80336 Munich, Germany
    J Neurol Neurosurg Psychiatry 76:138-40. 2005
    ..A novel technique for the kinematic analysis of emotionally induced facial expressions was applied to detect subtle mimic dysfunction in patients with depression...
  33. pmc Kinematic analysis of handwriting movements in patients with obsessive-compulsive disorder
    P Mavrogiorgou
    Laboratory of Clinical Neurophysiology and Outpatient Clinic for Obsessive-Compulsive Disorder, Department of Psychiatry, , Nussbaumstrasse 7, , Germany
    J Neurol Neurosurg Psychiatry 70:605-12. 2001
    ..The findings also support the concept that patients with OCD with early versus late age of onset differ in pathophysiological mechanisms and basal ganglia dysfunction...
  34. ncbi request reprint Schizophrenics with small P300: a subgroup with a neurodevelopmental disturbance and a high risk for tardive dyskinesia?
    U Hegerl
    Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Germany
    Acta Psychiatr Scand 91:120-5. 1995
    ..These findings indicate that schizophrenic patients with a reduced P3 have a higher risk of developing tardive dyskinesia and correspond clinically to a schizophrenic subgroup with a supposedly neurodevelopmental disturbance...
  35. ncbi request reprint The effect of the skull on event-related P300
    T Frodl
    Laboratory for Neuroimaging of Functional Psychosis, Department of Psychiatry, Ludwig Maximilians University Munich, Nussbaumstrasse 7, 80336 Munich, Germany
    Clin Neurophysiol 112:1773-6. 2001
    ..The aim of the present study was to investigate this influence of skull and scalp thicknesses on event-related P300 potentials...
  36. doi request reprint Single-trial coupling of the gamma-band response and the corresponding BOLD signal
    C Mulert
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
    Neuroimage 49:2238-47. 2010
    ..Single-trial coupling might be a useful method in order to increase our knowledge about the functional neuroanatomy of "neural ensembles" coupled by 40 Hz oscillations...
  37. ncbi request reprint Loudness dependence of primary auditory-cortex-evoked activity as predictor of therapeutic outcome to prophylactic lithium treatment in affective disorders--a retrospective study
    G Juckel
    Section of Clinical Neurophysiology, Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Pharmacopsychiatry 37:46-51. 2004
    ....
  38. ncbi request reprint Kinematical analysis of handwriting movements in depressed patients
    R Mergl
    Laboratory of Clinical Neurophysiology, Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Munchen, Germany
    Acta Psychiatr Scand 109:383-91. 2004
    ..We hypothesized that depressed patients draw and write significantly slower than controls and that motor disturbances become more pronounced under bi-manual demands...
  39. ncbi request reprint Corpus callosum and P300 in schizophrenia
    T Frodl
    Laboratory of Clinical Neurophysiology, Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336, Munich, Germany
    Schizophr Res 49:107-19. 2001
    ..The results are discussed in terms of the possibility that abnormalities in interhemispheric transfer may underlie the mechanisms of schizophrenia...
  40. ncbi request reprint Clinical and biological findings in a case with 48-hour bipolar ultrarapid cycling before and during valproate treatment
    G Juckel
    Department of Psychiatry, Ludwig Maximilians University Munich, Germany
    J Clin Psychiatry 61:585-93. 2000
    ..The rare cases of patients with 48-hour ultrarapid cycling allow close investigation of mood cycles in affective disorders, because rhythmic changes in psychopathologic state and biological parameters happen very precisely...
  41. pmc EEG coherence reflects regional corpus callosum area in Alzheimer's disease
    O Pogarell
    Department of Psychiatry, Ludwig Maximilians University of Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
    J Neurol Neurosurg Psychiatry 76:109-11. 2005
    ..Correlations between corpus callosum size and interhemispheric EEG coherence were investigated as measures of interhemispheric connectivity in patients with Alzheimer's disease...
  42. doi request reprint Treatment of atypical depression: post-hoc analysis of a randomized controlled study testing the efficacy of sertraline and cognitive behavioural therapy in mildly depressed outpatients
    V Henkel
    Department of Psychiatry, Ludwig Maximilians University Munich, Nussbaumstrasse 7, Munich, Germany
    Eur Psychiatry 25:491-8. 2010
    ..This paper examines the efficacy of sertraline and cognitive behavioural therapy (CBT) among depressed patients with atypical features...
  43. ncbi request reprint The neural basis of the P300 potential. Focus on the time-course of the underlying cortical generators
    C Mulert
    Laboratory for Clinical Neurophysiology, Department of Psychiatry, Nussbaumstrasse 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 254:190-8. 2004
    ..In these selected regions, an analysis of the activation time-courses has been performed...
  44. ncbi request reprint Prefrontal cortex modulation of mood and emotionally induced facial expressions: a transcranial magnetic stimulation study
    F Padberg
    Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    J Neuropsychiatry Clin Neurosci 13:206-12. 2001
    ..On the basis of this study, the authors propose to combine rTMS and facial expression analysis for further studies of the cortical modulation of emotions in humans...
  45. ncbi request reprint Markers from event-related potential subcomponents and reaction time for information processing dysfunction in schizophrenia
    T Frodl
    Department of Psychiatry, , Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 248:307-13. 1998
    ..The input-related processing stages (N100 and P200) were not altered, whereas later, the deviant and task-related processes (N200, frontal P300, parietal P300 and reaction time) were significantly prolonged in schizophrenia...
  46. ncbi request reprint Thalamic volume in first-episode and chronic schizophrenic subjects: a volumetric MRI study
    U W Preuss
    Department of Psychiatry, Psychiatrische Klinik und Poliklinik, Ludwig Maximilians Universitat Munchen, Nussbaumstr 7, 80336 Munchen, Germany
    Schizophr Res 73:91-101. 2005
    ....
  47. ncbi request reprint Assessment of handedness using a digitizing tablet: a new method
    V Henkel
    Department of Psychiatry, Ludwig Maximilians University Munich, Section of Clinical Neurophysiology, Nussbaumstr 7, 80336, Munich, Germany
    Neuropsychologia 39:1158-66. 2001
    ..According to our results handedness should be assessed not only with the EHI, but also with the computer-aided analysis of hand-movements...
  48. ncbi request reprint Residual symptoms and P300 in schizophrenic outpatients
    G Juckel
    Department of Psychiatry, Ludwig Maximilians University Munchen, Germany
    Psychiatry Res 65:23-32. 1996
    ..A reduced P300 amplitude may characterize a subgroup of schizophrenic patients with a disposition to cognitive disturbances and incomplete remissions...
  49. ncbi request reprint Ventricle size and P300 in schizophrenia
    G Juckel
    Department of Psychiatry, , Germany
    Eur Arch Psychiatry Clin Neurosci 243:352-4. 1994
    ..It is assumed that the P3 amplitude is related rather to abnormalities in the temporal lobe of schizophrenic patients...
  50. ncbi request reprint Periodic motor impairments in a case of 48-hour bipolar ultrarapid cycling before and under treatment with valproate
    P Tigges
    Department of Psychiatry, Section of Clinical Neurophysiology, Ludwig Maximilians University, Munich, Germany
    Neuropsychobiology 42:38-42. 2000
    ..Therefore, it can be assumed that the handwriting skills reflect a state marker of the disease. Poorer handwriting skills on the manic days, as compared to the depressive ones, support the hypothesis of a low arousal in manic patients...
  51. ncbi request reprint Depression with atypical features in a sample of primary care outpatients: prevalence, specific characteristics and consequences
    Verena Henkel
    Department of Psychiatry, Ludwig Maximilians University Munich, Nussbaumstr 7, D 80336 Munich, Germany
    J Affect Disord 83:237-42. 2004
    ....
  52. ncbi request reprint Kinematical analysis of motor function in schizophrenic patients: a possibility to separate negative symptoms from extrapyramidal dysfunction induced by neuroleptics?
    Verena Henkel
    Department of Psychiatry, Ludwig Maximilians University Munich, Munich, Germany
    Pharmacopsychiatry 37:110-8. 2004
    ..In this prospective matched case-control study, hand movement analysis was conducted using a digitizing tablet (kinematical analysis)...
  53. doi request reprint Age effects on the P300 potential and the corresponding fMRI BOLD-signal
    G Juckel
    Department of Psychiatry, Ruhr University Bochum, Bochum, Germany
    Neuroimage 60:2027-34. 2012
    ..Taken together, the results indicate diminished neural responses in older compared to younger subjects especially in frontal, temporo-parietal and subcortical brain regions...
  54. ncbi request reprint In-vivo analysis of the human planum temporale (PT): does the definition of PT borders influence the results with regard to cerebral asymmetry and correlation with handedness?
    T Zetzsche
    Department of Psychiatry, University of Munich, Ludwig Maximilians University, Nussbaumstr 7, 80336 Munich, Germany
    Psychiatry Res 107:99-115. 2001
    ..The possible implications of the correlation between handedness and the extension of the right parietal PT are discussed and have to be elucidated by further studies...
  55. ncbi request reprint Event-related potentials. Do they reflect central serotonergic neurotransmission and do they predict clinical response to serotonin agonists?
    U Hegerl
    Department of Psychiatry, Ludwig Maximilians Universitat, Nussbaumstr 7, D 80336, Munchen, Germany
    J Affect Disord 62:93-100. 2001
    ..Additionally, there is evidence from several studies with patients with affective disorders implicating a strong LDAEP as a predictor of favorable response to a preventive lithium treatment...
  56. ncbi request reprint Kinematical analysis of emotionally induced facial expressions in patients with obsessive-compulsive disorder
    R Mergl
    Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Laboratory of Clinical Neurophysiology, Munchen, Germany
    Psychol Med 33:1453-62. 2003
    ..To investigate subtle motor dysfunction, kinematical analysis of emotional facial expressions can be used. Our aim was to investigate facial movements in response to humorous film stimuli in OCD patients...
  57. ncbi request reprint Identifying psychiatric patients with serotonergic dysfunctions by event-related potentials
    U Hegerl
    Department of Psychiatry, Ludwig Maximilians Universitat, Nussbaumstr 7, 80336 Munchen, Germany
    World J Biol Psychiatry 1:112-8. 2000
    ..Additionally, there is evidence from several studies with patients with affective disorders that a strong LDAEP predicts favourable response to a preventive lithium treatment...
  58. ncbi request reprint How effective is advanced training concerning depression and suicidality among the elderly? Results of a pilot study
    Anja Ziervogel
    Department of Psychiatry, German Research Net on Depression and Suicidality, University of Munich, Munich, Germany
    Arch Suicide Res 9:11-7. 2005
    ..Attitude towards "suicide in old age" also changed significantly. The training program was effective in improving knowledge and attitudes of geriatric caregivers concerning depression and suicidality...
  59. ncbi request reprint Depressive, anxiety, and somatoform disorders in primary care: prevalence and recognition
    Roland Mergl
    Department of Psychiatry, Ludwig Maximilians University Munich, Munich, Germany
    Depress Anxiety 24:185-95. 2007
    ..These results confirm assumptions that the current division between depression and anxiety might be debatable. Validity of screeners tested in our study was not affected by comorbid conditions (e.g., anxiety or somatoform disorders)...
  60. ncbi request reprint Prolonged confusional state following electroconvulsive therapy--diagnostic clues from serial electroencephalography
    O Pogarell
    Department of Psychiatry, Ludwig Maximilians University of Munich, Munich, Germany
    Pharmacopsychiatry 38:316-20. 2005
    ..Since cognitive dysfunction can also be caused by ictal states, electroencephalography (EEG) is an essential tool for these conditions...
  61. ncbi request reprint P300 and symptom improvement in schizophrenia
    J Gallinat
    Department of Psychiatry, Laboratory of Clinical Psychophysiology, Free University Berlin, Eschenallee 3, 14050 Berlin, Germany
    Psychopharmacology (Berl) 158:55-65. 2001
    ..A reduced amplitude of the auditory evoked P300 was interpreted as a trait marker of schizophrenia but reports about correlations between schizophrenic psychopathology and P300 amplitude indicate also a state character...
  62. doi request reprint [Optimised services for depressed patients. The German Alliance Against Depression]
    A Cibis
    Klinik und Poliklinik fur Psychiatrie der Universitat Leipzig, Semmelweisstrasse 10, Leipzig, BRD
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 51:430-5. 2008
    ..Improving the care of affected persons requires a systematic research approach. The "Mental Health Research Network" contributes to research related to the optimisation of services for persons with mental disorders...
  63. ncbi request reprint Electrophysiological evidence for cortical abnormalities in obsessive-compulsive disorder - a replication study using auditory event-related P300 subcomponents
    Doris Gohle
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    J Psychiatr Res 42:297-303. 2008
    ..Once again, our findings point to a hyperactivated cortical state also of temporo-parietal and hippocampal regions in OCD...
  64. ncbi request reprint Use of brief depression screening tools in primary care: consideration of heterogeneity in performance in different patient groups
    Verena Henkel
    Department of Psychiatry, Ludwig Maximilians University Munich, Nussbaumstr 7, D 80336 Munich, Germany
    Gen Hosp Psychiatry 26:190-8. 2004
    ..This should be considered if routine depression screening should be widely introduced. Of course, the benefit of routine screening also depends on efforts made for treatment and monitoring of patients in whom depression was diagnosed...
  65. ncbi request reprint Can a subgroup of OCD patients with motor abnormalities and poor therapeutic response be identified?
    Roland Mergl
    Laboratory of Clinical Neurophysiology, Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Nussbaumstr 7, 80336 Munich, Bavaria, Germany
    Psychopharmacology (Berl) 179:826-37. 2005
    ..In a subgroup of patients with obsessive-compulsive disorder (OCD), motor soft signs, tics and other movement disorders can be observed, indicating a special pathogenetic involvement of basal ganglia...
  66. ncbi request reprint Depression in nursing homes: prevalence, recognition, and treatment
    Dietmar Kramer
    University of Leipzig, Germany
    Int J Psychiatry Med 39:345-58. 2009
    ..Therefore, the present study aimed at assessing accuracy of the unaided clinical diagnosis of the attending physicians, and the medical treatment situation in nursing home residents...
  67. doi request reprint The role of alcohol use disorder and alcohol consumption in suicide attempts--a secondary analysis of 1921 suicide attempts
    S Boenisch
    Department of Mental Health, University of Leipzig, Semmelweisstrasse 10, Leipzig, Germany
    Eur Psychiatry 25:414-20. 2010
    ..It is not known how characteristics of suicide attempts vary with different forms of alcohol involvement. The aim of this study is to clarify the role of alcohol use disorder and acute alcohol consumption in suicide attempts...
  68. doi request reprint Determination of nicotine and cotinine in human serum by means of LC/MS
    F Baumann
    Institute of Clinical Pharmacology, University of Leipzig, Leipzig, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 878:107-11. 2010
    ..The limits of quantification were 5 and 2ng/ml for cotinine and nicotine, respectively. A simultaneous study was conducted to measure nicotine receptor availability and the vigilance in the same group of volunteers...
  69. ncbi request reprint [Evaluation of an online discussion forum for depressive patients and their relatives--an examination focussing motives and effects of participation]
    Anne Blume
    Klinik und Poliklinik fur Psychiatrie, der Universität Leipzig
    Neuropsychiatr 23:42-51. 2009
    ..Furthermore, the effects of participation in the forum on individual handling of the illness are examined...
  70. ncbi request reprint Hand-motor dysfunction in depression: characteristics and pharmacological effects
    Roland Mergl
    Dept of Psychiatry, University Leipzig, Germany
    Clin EEG Neurosci 38:82-8. 2007
    ..II: Computer-aided analysis of hand movements is a sensitive tool for the registration of differential pharmaceutical effects on hand-motor function in depression...
  71. doi request reprint [Improvement of knowledge and attitudes towards depression and suicidality in geriatric caregivers: evaluation of an advanced training program]
    Antje Kathrin Allgaier
    Deutsches Bündnis gegen Depression eV, Klinik und Poliklinik fur Psychiatrie der Universitat Leipzig, Leipzig, Germany
    Z Gerontol Geriatr 42:228-35. 2009
    ..Especially pronounced effects were found for the attitudes towards depression and suicidality as well as treatability with antidepressants. These changes were stable, as indicated by the follow-up evaluation...
  72. doi request reprint EEG-vigilance and BOLD effect during simultaneous EEG/fMRI measurement
    Sebastian Olbrich
    Department of Psychiatry, University of Leipzig, Semmelweisstrasse 10, D 04103 Leipzig, Germany
    Neuroimage 45:319-32. 2009
    ..For cognitive fMRI-research it therefore seems important to pay attention to vigilance switches in order to separate vigilance associated BOLD signal changes from those specifically related to cognition...
  73. doi request reprint Impact of a campaign on the public's attitudes towards depression
    Sandra Dietrich
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Universitatsklinikum Leipzig, Semmelweisstrasse 10, D 04103 Leipzig, Germany
    Health Educ Res 25:135-50. 2010
    ..The fact that many of the changes in the general population declined in the second year of the campaign, when activities were done with lower intensity, illustrates the need for permanent depression awareness action...
  74. doi request reprint Time of mood switches in ultra-rapid cycling disorder: a brief review
    Kathrin Wilk
    University of Leipzig, Department of Psychiatry, Germany
    Psychiatry Res 180:1-4. 2010
    ..These findings indicate that in patients with mood cycles of 48h or less the switch process is closely linked to circadian aspects...
  75. doi request reprint ICA-based muscle artefact correction of EEG data: what is muscle and what is brain? Comment on McMenamin et al
    Sebastian Olbrich
    Department of Psychiatry and Psychotherapy of the University Clinic of Leipzig, Leipzig, Germany
    Neuroimage 54:1-3; discussion 4-9. 2011
    ..ICA-based artefact correction already provides a powerful tool for muscle artefact rejection. More research is needed for determining reliable criteria to delineate myogenic from neurogenic components...
  76. ncbi request reprint Effects of sertraline on kinematic aspects of hand movements in patients with obsessive-compulsive disorder
    Roland Mergl
    Department of Psychiatry, Laboratory of Clinical Neurophysiology, Ludwig Maximilians Universitat Munchen, Nussbaumstrasse 7, 80336, Munchen, Germany
    Psychopharmacology (Berl) 171:179-85. 2004
    ..Movement disorders such as disturbances of fine motor co-ordination are a frequent phenomenon in patients with obsessive-compulsive disorder (OCD)...
  77. doi request reprint EEG-vigilance and response to stimulants in paediatric patients with attention deficit/hyperactivity disorder
    Christian Sander
    Department of Psychiatry, University Hospital Leipzig, Leipzig, Germany
    Clin Neurophysiol 121:1511-8. 2010
    ..In a pilot study it was investigated whether assessment of EEG-vigilance is useful for the prediction of treatment outcome in ADHD patients...
  78. ncbi request reprint Symptom-specific EEG power correlations in patients with obsessive-compulsive disorder
    Oliver Pogarell
    Department of Psychiatry, Division of Clinical Neurophysiology, Ludwig Maximilians University of Munich, Germany
    Int J Psychophysiol 62:87-92. 2006
    ..The opposite correlations of neurophysiological data and clinical features, i.e. obsessions and compulsions, are suggestive of pathophysiological differences based on the presence of the respective cardinal symptoms of OCD...
  79. doi request reprint Seasonality of suicide attempts: association with gender
    Roland Mergl
    Department of Psychiatry, University of Leipzig, Semmelweisstr 10, 04103, Leipzig, Germany
    Eur Arch Psychiatry Clin Neurosci 260:393-400. 2010
    ..Whereas seasonality was absent in male suicide attempters, the frequency of low-risk suicide attempts in females was 13.1% lower than expected in the spring...
  80. doi request reprint Are treatment preferences relevant in response to serotonergic antidepressants and cognitive-behavioral therapy in depressed primary care patients? Results from a randomized controlled trial including a patients' choice arm
    Roland Mergl
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Psychother Psychosom 80:39-47. 2011
    ..We investigated whether better clinical outcome in depressed primary care patients is associated with receiving their preferred treatment...
  81. ncbi request reprint Kinematic analysis of handwriting movements in patients with Alzheimer's disease, mild cognitive impairment, depression and healthy subjects
    A Schroter
    Department of Psychiatry, Ludwig Maximilian University Munich, Munich, Germany
    Dement Geriatr Cogn Disord 15:132-42. 2003
    ..Both patients with MCI and patients with probable AD exhibited loss of fine motor performance. Movements of AD patients were significantly less regular than those of healthy controls...
  82. ncbi request reprint Cognitive-behavioural theories of helplessness/hopelessness: valid models of depression?
    V Henkel
    Department of Psychiatry, Ludwig Maximilians University Munich, Nussbaumstr 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 252:240-9. 2002
    ..Last but not least, the models are of high interest with respect to the theoretical background of important modules of cognitive-behavioural therapy and its acute and prophylactic effects...
  83. ncbi request reprint Public attitudes towards treatment of depression: effects of an information campaign
    U Hegerl
    University of Munich, Department of Psychiatry, Munich, Germany
    Pharmacopsychiatry 36:288-91. 2003
    ..However, no effects were found with respect to the misconceptions about pharmacotherapy...
  84. ncbi request reprint Comparison between the analysis of the loudness dependency of the auditory N1/P2 component with LORETA and dipole source analysis in the prediction of treatment response to the selective serotonin reuptake inhibitor citalopram in major depression
    C Mulert
    Laboratory for Clinical Neurophysiology, Department of Psychiatry, Nussbaumstrasse 7, 80336 Munchen, LMU, Munich, Germany
    Clin Neurophysiol 113:1566-72. 2002
    ..So far, LDAEP has been typically investigated with dipole source analysis, because with this method the primary and secondary auditory cortex (with a high versus low serotonergic innervation) can be separated at least in parts...
  85. ncbi request reprint Simultaneous ERP and event-related fMRI: focus on the time course of brain activity in target detection
    C Mulert
    Laboratory for Clinical Neurophysiology, Department of Psychiatry, LMU, Munich, Germany
    Methods Find Exp Clin Pharmacol 24:17-20. 2002
    ..For a comprehensive understanding of the brain activity underlying the P300 paradigm, we have used a combination of EEG and fMRI to get a precise localization and a high-time resolution of the underlying brain activity...
  86. ncbi request reprint Screening for depression in primary care: will one or two items suffice?
    Verena Henkel
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 254:215-23. 2004
    ....
  87. ncbi request reprint The alliance against depression: 2-year evaluation of a community-based intervention to reduce suicidality
    Ulrich Hegerl
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Psychol Med 36:1225-33. 2006
    ..The aim of the Nuremberg Alliance against Depression (NAD) is to establish and to assess the effectiveness of a four-level intervention program for improving the care of patients with depression...
  88. ncbi request reprint Differential effects of reboxetine and citalopram on hand-motor function in patients suffering from major depression
    Ulrich Hegerl
    Laboratory of Clinical Neurophysiology, Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Nussbaumstr 7, 80336, Munich, Germany
    Psychopharmacology (Berl) 178:58-66. 2005
    ..However, the effects of antidepressants on motor function in depression have rarely been analyzed systematically. Computerized methods allow the objective registration of drug-induced motor dysfunction and were applied in this study...
  89. ncbi request reprint Differential prediction of first clinical response to serotonergic and noradrenergic antidepressants using the loudness dependence of auditory evoked potentials in patients with major depressive disorder
    Georg Juckel
    Department of Psychiatry, Ruhr University Bochum, Bochum, Germany
    J Clin Psychiatry 68:1206-12. 2007
    ..The aim of the current randomized prospective study was to investigate whether or not LDAEP also allows the differential prediction of treatment response to serotonergic versus noradrenergic antidepressants...
  90. ncbi request reprint Elevated brain serotonin transporter availability in patients with obsessive-compulsive disorder
    Oliver Pogarell
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Biol Psychiatry 54:1406-13. 2003
    ..The aim of this study was to investigate the serotonin transporter availability in patients with OCD as an in vivo marker of the central serotonergic system...
  91. ncbi request reprint Serotonergic dysfunction in schizophrenia assessed by the loudness dependence measure of primary auditory cortex evoked activity
    Georg Juckel
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Schizophr Res 64:115-24. 2003
    ..These results suggest that the loudness dependence of primary auditory cortex evoked activity is well suitable to assess serotonergic dysfunction in schizophrenia...
  92. ncbi request reprint Evidence for a close relationship between conscious effort and anterior cingulate cortex activity
    Christoph Mulert
    Department of Psychiatry, Nussbaumstrasse 7, LMU, Munich 80336 München, Germany
    Int J Psychophysiol 56:65-80. 2005
    ..These results provide direct evidence for a close relationship between conscious effort and ACC activity and suggest the usefulness of the applied effort-self-rating...
  93. ncbi request reprint Loudness dependence of auditory evoked potentials is not associated with polymorphisms or haplotypes in the serotonin transporter gene in a community-based sample of German healthy volunteers
    Georg Juckel
    Department of Psychiatry, Ruhr University Bochum, Germany
    Psychiatry Res 153:183-7. 2007
    ..We speculate that the LD endophenotype depends more on genetic variations in components of the serotonergic system controlling release than on those controlling the uptake mechanism...
  94. ncbi request reprint P300 subcomponents in obsessive-compulsive disorder
    Paraskevi Mavrogiorgou
    Department of Psychiatry, Section of Clinical Neurophysiology and Outpatient Clinic for Obsessive Compulsive Disorder, Ludwig Maximilians University Munich, Germany
    J Psychiatr Res 36:399-406. 2002
    ....
  95. ncbi request reprint Prediction of treatment response in major depression: integration of concepts
    Christoph Mulert
    Department of Psychiatry, LMU, Munich, Germany
    J Affect Disord 98:215-25. 2007
    ..Here, a high LDAEP is supposed to reflect low central serotonergic activity. We present the first study comparing both approaches in the same group of patients...
  96. ncbi request reprint Facial expressions and personality: a kinematical investigation during an emotion induction experiment
    Roland Mergl
    Department of Psychiatry, Ludwig Maximilians University Munich, Nussbaumstrasse 7, DE 80336 Munich, Germany
    Neuropsychobiology 54:114-9. 2006
    ....
  97. ncbi request reprint Prediction of clinical response to antidepressants in patients with depression: neurophysiology in clinical practice
    Oliver Pogarell
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Clin EEG Neurosci 38:74-7. 2007
    ..This review focuses on recent studies providing evidence for the validity of LD as an indirect serotonergic marker and highlights data on the clinical application in terms of prediction of treatment response in patients with depression...
  98. ncbi request reprint Rostral anterior cingulate cortex activity in the theta band predicts response to antidepressive medication
    Christoph Mulert
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Clin EEG Neurosci 38:78-81. 2007
    ..In addition to major differences between responders and nonresponders in the rostral ACC, we have identified a nearby region in the midline orbito-frontal region...
  99. ncbi request reprint Treatment of depression with atypical features: a meta-analytic approach
    Verena Henkel
    Department of Psychiatry, Laboratory of Clinical Neurophysiology, Ludwig Maximilians University Munich, Nussbaumstr 7, D 80336 Munich, Germany
    Psychiatry Res 141:89-101. 2006
    ..The available data are insufficient for a direct comparison between MAOIs and selective serotonin reuptake inhibitors...
  100. pmc Identifying depression in primary care: a comparison of different methods in a prospective cohort study
    Verena Henkel
    Department of Psychiatry, Ludwig Maximilians University Munich, Nussbaumstr 7, D 80336 Munich, Germany
    BMJ 326:200-1. 2003
  101. ncbi request reprint Superior temporal gyrus and P300 in schizophrenia: a combined ERP/structural magnetic resonance imaging investigation
    E M Meisenzahl
    Department of Psychiatry, Psychiatrische Klinik der LMU München, Nussbaumstr 7, 80 336, Munich, Germany
    J Psychiatr Res 38:153-62. 2004
    ..No associations between the electrophysiological and structural measurements could be detected. There were also no significant reductions of ERP and MRI measurements within the subgroup of patients with pronounced negative symptoms...