Peter Heger

Summary

Affiliation: University of Cologne
Country: Germany

Publications

  1. Jabbari K, Heger P, Sharma R, Wiehe T. The Diverging Routes of BORIS and CTCF: An Interactomic and Phylogenomic Analysis. Life (Basel). 2018;8: pubmed publisher
  2. Schiffer P, Kroiher M, Kraus C, Koutsovoulos G, Kumar S, Camps J, et al. The genome of Romanomermis culicivorax: revealing fundamental changes in the core developmental genetic toolkit in Nematoda. BMC Genomics. 2013;14:923 pubmed publisher
    ..Embryogenesis of the enoplean Romanomermis culicivorax has been studied in detail, but the genetic circuitry underpinning development in this species has not been explored...
  3. Heger P, Marin B, Schierenberg E. Loss of the insulator protein CTCF during nematode evolution. BMC Mol Biol. 2009;10:84 pubmed publisher
    ..Here, all or some of these components are missing. Instead operons, polycistronic transcriptional units common in derived nematodes, seemingly adopted their function. ..
  4. Heger P, Marin B, Bartkuhn M, Schierenberg E, Wiehe T. The chromatin insulator CTCF and the emergence of metazoan diversity. Proc Natl Acad Sci U S A. 2012;109:17507-12 pubmed publisher
    ..Such a kernel could explain (i) the formation of Hox clusters in Bilateria, (ii) the diversity of bilaterian body plans, and (iii) the uniqueness and time of onset of the Cambrian explosion. ..
  5. Heger P, George R, Wiehe T. Successive gain of insulator proteins in arthropod evolution. Evolution. 2013;67:2945-56 pubmed publisher
    ..Expansion of insulator systems may therefore be a general strategy to increase an organism's gene regulatory repertoire and its potential for morphological plasticity. ..
  6. Heger P, Kroiher M, Ndifon N, Schierenberg E. Conservation of MAP kinase activity and MSP genes in parthenogenetic nematodes. BMC Dev Biol. 2010;10:51 pubmed publisher
    ..elegans, thus requiring intact MSP genes. However, MSP expression has been shifted to non-sperm cells and is reduced below the detection limits, but is still sufficient to trigger MAP kinase activation and embryogenesis. ..