Research Topics
Genomes and GenesSpecies | Christoph HeesenSummaryAffiliation: University of Hamburg Country: Germany Publications
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Detail Information
Publications
Delivering the diagnosis of MS--results of a survey among patients and neurologistsC Heesen
Department of Neurology, University Hospital Eppendorf, Hamburg, Germany
Acta Neurol Scand 107:363-8. 2003..We assessed the current status of diagnostic and therapeutic information on MS from the point of view of patients and neurologists...
Correlates of cognitive dysfunction in multiple sclerosisC Heesen
Institute of Neuroimmunology and Clinical MS Research, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
Brain Behav Immun 24:1148-55. 2010..We conclude that fatigue and depression are the main correlates of cognitive impairment, which show domain-specific associations with measures of attention and memory...- Behavioral interventions in multiple sclerosis: a biopsychosocial perspectiveC Heesen
University Medical Center Hamburg Eppendorf, Institute for Neuroimmunology and Clinical MS Research and Department of Neurology, Hamburg, Germany
Expert Rev Neurother 12:1089-100. 2012..Therefore, behavioral interventions not only ameliorate symptoms but may have the potential to modify the disease process itself... - [Results of radiotherapy for vertebral hemangioma]S Brackrock
Abteilung für Strahlentherapie und Radioonkologie, Universitätskrankenhaus Hamburg Eppendorf
Strahlenther Onkol 175:405-8. 1999..Assessment of treatment results of symptomatic vertebral hemangiomas and review of the literature (Table 3)... - Altered cytokine responses to cognitive stress in multiple sclerosis patients with fatigueChristoph Heesen
Department of Neurology, University Hospital Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
Mult Scler 11:51-7. 2005..05). Overall, cognitive stress induces IFNgamma production in healthy controls but not in MS patients with fatigue. Furthermore, a reduced cardiac response might indicate an autonomic dysfunction in this group of patients... - Patient perception of bodily functions in multiple sclerosis: gait and visual function are the most valuableC Heesen
Institute of Neuroimmunology and Clinical MS Research, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Mult Scler 14:988-91. 2008..These results underline that ambulation-focused scales in MS represent a key dimension from the patient perspective. Visual functioning should be taken more into account... - Decisions on multiple sclerosis immunotherapy: new treatment complexities urge patient engagementChristoph Heesen
Institute of Neuroimmunology and Clinical MS Research inims, University Medical Center Hamburg Eppendorf, Hamburg, Germany
J Neurol Sci 306:192-7. 2011..Still, it remains a challenge to adequately assess decision quality. Therefore, a study in six European and one Australian centers will start soon aiming to establish adequate tools to assess decision-making quality... 
Fatigue in multiple sclerosis: an example of cytokine mediated sickness behaviour?C Heesen
Department of Neurology, University Hospital Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
J Neurol Neurosurg Psychiatry 77:34-9. 2006..Evidence from chronic fatigue syndrome and studies on sickness behaviour suggest that immune and neuroendocrine factors may play a causative role in the development of fatigue...- Physical exercise in multiple sclerosis: supportive care or a putative disease-modifying treatmentChristoph Heesen
Department of Neurology, University Medical Center, Martinistrasse 52, 20246 Hamburg, Eppendorf, Germany
Expert Rev Neurother 6:347-55. 2006..Possible biological effect mediators, such as neurotrophic factors or anti-inflammatory cytokines, will be discussed. Exercise management guidelines will be proposed and possible further research strategies are presented... - Risk perception in natalizumab-treated multiple sclerosis patients and their neurologistsChristoph Heesen
Institute of Neuroimmunology and Clinical MS Research inims, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Mult Scler 16:1507-12. 2010..Natalizumab is associated with the potentially life-threatening side-effect progressive multifocal leukoencephalopathy (PML). Little is known about patients' and physicians' risk estimates and attitudes towards natalizumab treatment... - Informed shared decision making in multiple sclerosis--inevitable or impossible?C Heesen
Institute of Neuroimmunology and Clinical Multiple Sclerosis Research INIMS, Hamburg Eppendorf, Germany
J Neurol Sci 259:109-17. 2007..Results in early 2007 will show to which extent patient education with a focus on evidence-based patient information influences participation in the decision making process... - Stress regulation in multiple sclerosis: current issues and conceptsC Heesen
Department of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Mult Scler 13:143-8. 2007..Consensus statements from the group to these aspects are given. Research objectives and strategies are delineated, as well as clinical implications... - Shared decision making and self-management in multiple sclerosis--a consequence of evidenceChristoph Heesen
Dept of Neurology, University Medical Center, Martinistr 52, 20246, Hamburg, Germany
J Neurol 254:II116-21. 2007..Assuming that patient education programmes will enhance self-management abilities and the sense of control over the disease with enhanced quality of life and well-being, further modules covering all aspects of MS are to be developed... - Stress and hypothalamic-pituitary-adrenal axis function in experimental autoimmune encephalomyelitis and multiple sclerosis - a reviewC Heesen
Institute of Neuroimmunology and Clinical MS Research inims, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
Psychoneuroendocrinology 32:604-18. 2007..Hyper- and hypoactivity of the HPA axis, have been described to be associated with more severe courses. This paper presents an overview of the evidence for a role of HPA dysfunction in EAE and MS based on stress-experimental studies... - Suspected multiple sclerosis - what to do? Evaluation of a patient information leafletC Heesen
Institute of Neuroimmunology and Clinical MS Research inims, University Medical Center Hamburg Eppendorf, Martinistrasse, Hamburg, Germany
Mult Scler 15:1103-12. 2009.... - Decisional role preferences, risk knowledge and information interests in patients with multiple sclerosisChristoph Heesen
Department of Neurology, University Hospital Eppendorf, Hamburg, Germany
Mult Scler 10:643-50. 2004..To evaluate prerequisite factors for this kind of decision making we studied patients' decisional role preferences in medical decision making, knowledge on risks, information interests and the relations between these factors in MS... - CD95-mediated apoptosis and DNA fragmentation in MSC Heesen
Department of Neurology, University of Hamburg, Germany
Acta Neurol Scand 102:333-6. 2000..To investigate possible associations of soluble CD95 (sCD95) serum levels and DNA defragmentation with different MS disease stages and activities... - Oral terbutaline differentially affects cytokine (IL-10, IL-12, TNF, IFNg) release in multiple sclerosis patients and controlsChristoph Heesen
Department of Neurology, University Hospital Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
J Neuroimmunol 132:189-95. 2002..Our findings might reflect a disturbed autonomic control of the immune system in MS... - Cognitive impairment correlates with hypothalamo-pituitary-adrenal axis dysregulation in multiple sclerosisChristoph Heesen
Department of Neurology, University Hospital Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
Psychoneuroendocrinology 27:505-17. 2002..We conclude that the observed dysregulation is more likely a secondary effect of the extent of brain damage rather than primarily involved in the pathogenesis of MS... - Endocrine and cytokine responses to standardized physical stress in multiple sclerosisChristoph Heesen
Department of Neurology, University Hospital Eppendorf, Martinistrasse 53, D 20246 Hamburg, Germany
Brain Behav Immun 17:473-81. 2003..From these data we could not demonstrate a proinflammatory immune deviation in response to physical stress in MS. The observed trend of hyporesponsive TNFalpha and IL-10 responses in MS warrants further investigation... - Prolactin stimulation in multiple sclerosis--an indicator of disease subtypes and activity?Christoph Heesen
Department of Neurology, University of Hamburg, Germany
Endocr Res 28:9-18. 2002..Nevertheless in the regression analysis of stimulatory test results, 14% of the variance was attributable to disease activity. In conclusion PRL does not seem to be relevant as an activity marker in the whole MS population... - Hypothalamo-pituitary-adrenal axis activity predicts disease progression in multiple sclerosisStefan M Gold
Department of Neurology, University Hospital Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
J Neuroimmunol 165:186-91. 2005..Furthermore, HPA axis activity correlated with progression ratings and cognitive impairment three years later. Tests of HPA axis activity may be useful biomarkers for disease progression in MS... - Impact of aerobic training on immune-endocrine parameters, neurotrophic factors, quality of life and coordinative function in multiple sclerosisKarl-Heinz Schulz
Institute of Medical Psychology and Transplantation-Center, University Hospital Eppendorf, Martinistrasse 52, S3520246 Hamburg, Germany
J Neurol Sci 225:11-8. 2004..In summary, low-level aerobic training in MS improves not only quality of life but also coordinative function and physical fitness... - Basal serum levels and reactivity of nerve growth factor and brain-derived neurotrophic factor to standardized acute exercise in multiple sclerosis and controlsStefan M Gold
Department of Neurology, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
J Neuroimmunol 138:99-105. 2003..We conclude that moderate exercise can be used to induce neutrophin production in humans. This may mediate beneficial effects of physical exercise in MS reported recently... - Implementation of a patient education program on multiple sclerosis relapse managementSascha Köpke
Institute of Neuroimmunology and Clinical MS Research inims, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Patient Educ Couns 86:91-7. 2012..To study the implementation of a patient education program on relapses and relapse therapy into routine care... - Patients' and observers' perceptions of involvement differ. Validation study on inter-relating measures for shared decision makingJürgen Kasper
Institute of Neuroimmunology and Clinical MS Research, University Medical Center Hamburg, Hamburg, Germany
PLoS ONE 6:e26255. 2011..While use and reporting of these instruments might imply wide overlap regarding the addressed constructs this assumption seems questionable with respect to the diversity of the perspectives from which the assessments are administered... - Applying the theory of planned behaviour to multiple sclerosis patients' decisions on disease modifying therapy--questionnaire concept and validationJürgen Kasper
Institute of Neuroimmunology and Clinical MS Research inims and Department of Neurology, University Medical Center, Hamburg, Germany
BMC Med Inform Decis Mak 12:60. 2012..Our aim was therefore to develop and validate an instrument modeling the process of multiple sclerosis (MS) patients' decision making about whether to undergo disease modifying (immuno-)therapies (DMT)... - Evidence-based patient information about treatment of multiple sclerosis--a phase one study on comprehension and emotional responsesJürgen Kasper
Unit of Health Sciences and Education, University of Hamburg, Martin Luther King Platz 6, 20146 Hamburg, Germany
Patient Educ Couns 62:56-63. 2006..The core module is designed to enable patients to process scientific uncertainty without adverse effects. It considers existing standards for risk communication and presentation of data... - Completing the third person's perspective on patients' involvement in medical decision-making: approaching the full pictureJürgen Kasper
Department of Primary Medical Care, University Medical Center Hamburg, Germany
Z Evid Fortbild Qual Gesundhwes 106:275-83. 2012..Content and quality of information provided to involve patients in medical decisions are hardly considered in evaluation of SDM. This study investigates the advantages of a revised observer inventory taking into account these aspects... - Endocrine and cytokine responses to acute psychological stress in multiple sclerosisChristoph Heesen
Department of Neurology, University Hospital Hamburg-Eppendorf, Hamburg, Germany
Brain Behav Immun 16:282-7. 2002..An altered neural immune signaling in relapsing-remitting MS patients during acute experimental stress could not be proven for the parameters analyzed... - Decreased hydrocortisone sensitivity of T cell function in multiple sclerosis-associated major depressionAnja Fischer
Institute for Neuroimmunology and Clinical Multiple Sclerosis Research, Center for Molecular Neurobiology, University Hospital Hamburg Eppendorf, Hamburg, Germany
Psychoneuroendocrinology 37:1712-8. 2012..To our knowledge, this study provides first evidence for altered steroid sensitivity of T cells from MS patients with comorbid MDD possibly due to MR dysregulation... - Cognitive impairment in multiple sclerosis does not affect reliability and validity of self-report health measuresStefan M Gold
Multiple Sclerosis Research Group, Department of Neurology, University Hospital Eppendorf, Hamburg, Germany
Mult Scler 9:404-10. 2003..The common pattern of poor correlation between self-rated and objective cognitive function thus appears to be a result of the patients' (adaptive or maladaptive) coping mechanisms rather than being due to inaccurate measurement... - Childhood trauma in multiple sclerosis: a case-control studyCarsten Spitzer
Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg Eppendorf and Schön Klinik Hamburg Eilbek, Martinistr 52, 20246 Hamburg, Germany
Psychosom Med 74:312-8. 2012.... - Effects of mitoxantrone on multiple sclerosis patients' lymphocyte subpopulations and production of immunoglobulin, TNF-alpha and IL-10Joystone Gbadamosi
Department of Neurology, University Hospital Hamburg, Germany
Eur Neurol 49:137-41. 2003.... - Informed shared decision making about immunotherapy for patients with multiple sclerosis (ISDIMS): a randomized controlled trialJ Kasper
Institute of Neuroimmunology and Clinical MS Research, University of Hamburg, Hamburg, Germany
Eur J Neurol 15:1345-52. 2008..To evaluate the effects of an evidence-based patient decision aid (DA) on multiple sclerosis (MS) immunotherapy... - MAPPIN'SDM--the multifocal approach to sharing in shared decision makingJürgen Kasper
Faculty of Mathematics, Informatics, Unit of Health Sciences and Education, University of Hamburg, Hamburg, Germany
PLoS ONE 7:e34849. 2012..This study aims at investigating interrelations of SDM indicators administered from different perspectives... - Endocrine and immune substrates of depressive symptoms and fatigue in multiple sclerosis patients with comorbid major depressionStefan M Gold
Institute for Neuroimmunology und Clinical Multiple Sclerosis Research inims, Falkenried 94, D 20251 Hamburg, Germany
J Neurol Neurosurg Psychiatry 82:814-8. 2011..In this study, the relative role of cytokines and hypothalamic-pituitary-adrenal (HPA) axis activity in depression and fatigue were examined in patients with relapsing-remitting MS (RRMS)... - [Criteria for evidence-based patient information]Anke Steckelberg
Universitat Hamburg, Fachwissenschaft Gesundheit
Z Arztl Fortbild Qualitatssich 99:343-51. 2005..The presentation of information should be clear and consider risk communication as a source of framing of data. Patients should be involved in the process of development and evaluation... - Responsiveness of patient-based and external rating scales in multiple sclerosis: head-to-head comparison in three clinical settingsStefan M Gold
Department of Neurology, UCLA School of Medicine, Los Angeles, CA, USA
J Neurol Sci 290:102-6. 2010..Responsiveness to health-related change of quality of life scales is thus an important property when these measures are to be used successfully in clinical trials... - [The concept of allostasis and allostatic load: psychoneuroimmunological findings]Karl Heinz Schulz
Institut und Poliklinik für Medizinische Psychologie, Zentrum fur Psychosoziale Medizin
Psychother Psychosom Med Psychol 55:452-61. 2005..When using allostatic load as a heuristic model, one needs to consider that stress mediators and outcomes are interconnected in a non-linear network... - Patient education program to enhance decision autonomy in multiple sclerosis relapse management: a randomized-controlled trialS Köpke
Unit of Health Sciences and Education, University of Hamburg, Hamburg, Germany
Mult Scler 15:96-104. 2009..Oral corticosteroids administered by physicians or patients themselves or no corticosteroids also appear justifiable... - Failure of ondansetron in treating cerebellar tremor in MS patients--an open-label pilot studyJ Gbadamosi
Department of Neurology, University of Hamburg, Germany
Acta Neurol Scand 104:308-11. 2001..We neither found significant improvement in the upper extremity tests nor in the subjective response of the patients. In conclusion we could not confirm a beneficial effect of ondansetron on cerebellar tremor of MS patients... - Collateral circulation is an independent radiological predictor of outcome after thrombolysis in acute ischaemic strokeT Kucinski
Department of Neuroradiology, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20251 Hamburg, Germany
Neuroradiology 45:11-8. 2003..9, 95% confidence interval 1.3-26.7, P=0.02). EIS were not predictive in either case. Occlusion type and recanalisation, are related to outcome only if adequate collateralisation prevents infarction until recanalisation occurs... - Visual recovery in a man with the rare combination of mtDNA 11778 LHON mutation and a MS-like disease after mitoxantrone therapyC Buhmann
Department of Neurology, University Hospital Eppendorf, Hamburg, Germany
Acta Neurol Scand 106:236-9. 2002..We suggest a search for the LHON mutation in MS patients with predominant visual impairment, independent of patients' gender... - Steroid treatment for relapses in multiple sclerosis - the evidence urges shared decision-makingS Köpke
Department of Neurology, University Hospital Eppendorf, Hamburg, Germany
Acta Neurol Scand 110:1-5. 2004..The British General Medical Council (GMC) has published ethical guidelines on seeking patients' consent for medical interventions, formulating topics of information patients need in order to make an informed treatment decision... - Motor cortex excitability and fatigue in multiple sclerosis: a transcranial magnetic stimulation studyJ Liepert
Department of Neurology, University Hospital Eppendorf, Hamburg, Germany
Mult Scler 11:316-21. 2005..We conclude that MS patients with fatigue have an impairment of inhibitory circuits in their primary motor cortex. The results also indicate that fatigue severity is associated with an exercise-induced reduction of membrane excitability... - Patient information on cognitive symptoms in multiple sclerosis - acceptability in relation to disease durationC Heesen
Department of Neurology, University Medical Center Hamburg, Hamburg, Germany
Acta Neurol Scand 114:268-72. 2006..Recently, regular cognitive screening assessments have been advised in multiple sclerosis (MS). No studies have been carried out yet on the acceptability of information on cognitive deficits among MS patients... - [Effects of exercise in chronically ill patients. Examples from oncology and neurology]K H Schulz
Universitätsklinikum Eppendorf, Hamburg
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 48:906-13. 2005..Potential pathophysiological pathways regarding a progression to dementia are presented. Consequently exercise programs could play a pivotal role in the prevention and therapy of the cognitive decline in the aged in an aging society... - Why not? - Communicating stochastic information by use of unsorted frequency pictograms - a randomised controlled trialJürgen Kasper
Institute of Neuroimmunology and Clinical MS Research inims, University Medical Center Hamburg, Germany
Psychosoc Med 8:Doc08. 2011..General poor performance and the corresponding high variance of recall might have clouded existing effects of the arrangement types. More research is needed with varying proportions and other samples... - Placebo cohorts in phase-3 MS treatment trials - predictors for on-trial disease activity 1990-2010 based on a meta-analysis and individual case dataJan Patrick Stellmann
Institute for Neuroimmunology and Clinical MS Research inims and Department of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
PLoS ONE 7:e50347. 2012..The causes of these changes are not clear. We consider a better understanding of this phenomenon essential for valuing the effects of new drugs and by designing new trials... - Escalating immunotherapy of multiple sclerosis--new aspects and practical applicationP Rieckmann
Dept of Neurology, Josef Schneider Str 11, 97080, Wurzburg, Germany
J Neurol 251:1329-39. 2004..Moreover, in long-term treated patients, secondary treatment failure should be identified by pre-planned follow-up examinations, and other treatment options should then be considered... - Intravenous immunoglobulin in primary and secondary chronic progressive multiple sclerosis: a randomized placebo controlled multicentre studyD Pöhlau
Department of Neurology, Multiple Sclerosis Center, Kamillus Klinik Asbach, Germany
Mult Scler 13:1107-17. 2007..Treatment was generally well tolerated. It was concluded that monthly IVIG infusion could delay progression of disease in patients with PPMS, and that there was a trend in favour of IVIG treatment in patients with SPMS... - Biological outcome measurements for behavioral interventions in multiple sclerosisAnja Fischer
Institute for Neuroimmunology and Clinical Multiple Sclerosis Research inims, University Hospital Hamburg, Eppendorf, Germany
Ther Adv Neurol Disord 4:217-29. 2011..We focus on two areas of interest as potential targets for behavioral interventions: depression and fatigue... - Stem cell transplantation in multiple sclerosisSven Schippling
Institute of Neuroimmunology and Multiple Sclerosis Research INiMS, Center of Molecular Neurobiology, Falkenried 3, 20246 Hamburg, Germany
J Neurol 255:43-7. 2008.... - Early anisotropy changes in the corpus callosum of patients with optic neuritisM Bester
Department of Neuroradiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Neuroradiology 50:549-57. 2008..In this prospective study we aimed to determine whether diffusion tensor imaging (DTI) could quantify structural changes in patients with early MS... - Disease specific quality of life instruments in multiple sclerosis: validation of the Hamburg Quality of Life Questionnaire in Multiple Sclerosis (HAQUAMS)S M Gold
Department of Neurology, University Hospital Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
Mult Scler 7:119-30. 2001..No floor or ceiling effects were found in either of the HAQUAMS subscales. The HAQUAMS is a reliable, valid and appropriate instrument for QoL assessment in multiple sclerosis. Data of responsiveness are currently being obtained... - Protocol for German trial of Acyclovir and corticosteroids in Herpes-simplex-virus-encephalitis (GACHE): a multicenter, multinational, randomized, double-blind, placebo-controlled German, Austrian and Dutch trial [ISRCTN45122933]Francisco Martinez-Torres
Department of Neurology, University of Heidelberg, Germany
BMC Neurol 8:40. 2008..But currently there is no available evidence to support the routine use of adjuvant corticosteroid treatment in HSVE. A randomized multicenter trial is the only useful instrument to address this question... - Stress and disease progression in multiple sclerosis and its animal modelsStefan M Gold
Multiple Sclerosis Program, Department of Neurology and Cousins Center for Psychoneuroimmunology, UCLA School of Medicine, Los Angeles, CA 90095, USA, and University Hospital Hamburg Eppendorf, Germany
Neuroimmunomodulation 13:318-26. 2006..These findings can be integrated into a biological model of stress response system alterations in MS... - Participation preferences of patients with acute and chronic conditionsJohannes Hamann
Klinik und Poliklinik für Psychiatrie und Psychotherapie der TU München, Munchen, Germany
Health Expect 10:358-63. 2007..There is little knowledge as to whether the chronicity of a disease affects patients' desire for participation... - Corticosteroids treatment of multiple sclerosisSascha Köpke
J Neurol Sci 234:117-8; author reply 119-20. 2005 - The role of stress-response systems for the pathogenesis and progression of MSStefan M Gold
Multiple Sclerosis Program, Department of Neurology and Cousins Center for Psychoneuroimmunology, Neuropsychiatric Institute, UCLA School of Medicine, NRB1 (Rm 479, 635 Charles E. Young Drive South, Los Angeles, CA 90095, USA
Trends Immunol 26:644-52. 2005..Here, we integrate findings from molecular, cellular, experimental, clinical and epidemiological research to describe the involvement of stress response systems in MS pathogenesis and progression...