Research Topics
| Jurgen HeesemannSummaryAffiliation: University of Munich Country: Germany Publications
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Detail Information
Publications
Yersinia's stratagem: targeting innate and adaptive immune defenseJurgen Heesemann
Max von Pettenkofer Institut, Pettenkoferstrasse 9 a, D 80336 Muenchen, Germany
Curr Opin Microbiol 9:55-61. 2006....
The Yersinia enterocolitica type three secretion chaperone SycO is integrated into the Yop regulatory network and binds to the Yop secretion protein YscM1Svea Dittmann
Max von Pettenkofer Institut, Lehrstuhl für Bakteriologie, Ludwig Maximilians Universitat Munchen, Munchen, Germany
BMC Microbiol 7:67. 2007..The effectors YopO and YopP are encoded on an operon together with SycO, the chaperone of YopO. The characterization of SycO is the focus of this study...- The two-component sensor kinase TcsC and its role in stress resistance of the human-pathogenic mold Aspergillus fumigatusAllison McCormick
Max von Pettenkofer Institut, Ludwig Maximilians University, Munich, Germany
PLoS ONE 7:e38262. 2012..Although TcsC plays a role in the adaptation of A. fumigatus to hypoxia, it seems to be dispensable for virulence... 
The Yersinia enterocolitica type 3 secretion system (T3SS) as toolbox for studying the cell biological effects of bacterial Rho GTPase modulating T3SS effector proteinsStefan Wolke
Max von Pettenkofer Institut, LMU Munich, Pettenkofer Straße 9A, 80336 Munich, Germany
Cell Microbiol 13:1339-57. 2011..In summary, the Yersinia toolbox is suitable to study cellular effects of effector proteins of diverse bacterial species separately or in combination in the context of bacterial T3SS-mediated injection...- Yersinia enterocolitica type III secretion: evidence for the ability to transport proteins that are folded prior to secretionGottfried Wilharm
Max von Pettenkofer Institut, Pettenkoferstr, 9a, D 80336 MUnchen, Germany
BMC Microbiol 4:27. 2004..It was suggested that folding is prevented either by co-translational secretion or by the assistance of specific Yop chaperones (called Sycs)... - Farnesol misplaces tip-localized Rho proteins and inhibits cell wall integrity signalling in Aspergillus fumigatusKarl Dichtl
Max von Pettenkofer Institut, Ludwig Maximilians Universitat, Munich, Germany
Mol Microbiol 76:1191-204. 2010..After farnesol treatment this localization is rapidly lost, which is accompanied by swelling of the hyphal tips. Parallel displacement of tropomyosin from the tips suggests a concomitant disorganization of the apical actin cytoskeleton... - Characterisation of the CipC-like protein AFUA_5G09330 of the opportunistic human pathogenic mould Aspergillus fumigatusBettina Bauer
Max von Pettenkofer Institut, Ludwig Maximilians Universitat, Munich, Germany
Mycoses 53:296-304. 2010..fumigatus during infection. Further studies are required to define the biological function of this hyphae-specific protein and its potential relevance for the pathogenicity of A. fumigatus... - On the role of specific chaperones, the specific ATPase, and the proton motive force in type III secretionGottfried Wilharm
Max von Pettenkofer Institut, Lehrstuhl für Bakteriologie, Ludwig Maximilians Universitat Munchen, Pettenkoferstrasse 9a, D 80336 Munich, Germany
Int J Med Microbiol 297:27-36. 2007..Here, we focus on the role of specific T3SS chaperones, the specific ATPase, and the proton motive force in type III secretion... - Bacterial toxins induce sustained mRNA expression of the silencing transcription factor klf2 via inactivation of RhoA and Rhophilin 1Kristina Dach
Department of Bacteriology, Max von Pettenkofer Institut, Pettenkoferstr 9a, 80336 Munich, Germany
Infect Immun 77:5583-92. 2009..Thus, bacteria exploit the RhoA-rhophilin signaling cascade to mediate sustained expression of the immunosuppressive transcription factor klf2... - Yersinia enterocolitica type III secretion depends on the proton motive force but not on the flagellar motor components MotA and MotBGottfried Wilharm
Bakteriologie, Max von Pettenkofer Institut, Pettenkoferstrasse 9a, D 80336 Munich, Germany
Infect Immun 72:4004-9. 2004..Thus, the hypothesis that the Ysc TTSS might adopt flagellar motor components was not confirmed. The finding that, in addition to consumption of ATP, Ysc TTSS requires the proton motive force is discussed... - Yersinia as oral live carrier vaccine: influence of Yersinia outer proteins (Yops) on the T-cell responseKonrad Trulzsch
Max von Pettenkofer Institut, LMU Munchen, Pettenkoferstr 9a, D 80336 MUnchen, Germany
Int J Med Microbiol 298:59-67. 2008.... - AfMkk2 is required for cell wall integrity signaling, adhesion, and full virulence of the human pathogen Aspergillus fumigatusFranziska Dirr
Max von Pettenkofer Institut, Ludwig Maximilians Universitat, Pettenkoferstraße 9a, 80336 Munich, Germany
Int J Med Microbiol 300:496-502. 2010..And in agreement with its sensitivity to moderate temperatures, it is less virulent in a murine infection model. Our data underline the importance of mkk2 for the fitness, but also for the pathogenicity of A. fumigatus... - Transcriptional responses of murine macrophages to infection with Yersinia enterocoliticaReinhard Hoffmann
Max von Pettenkofer Institut, Bacteriology Department, Pettenkoferstrasse 9a, 80336 Munich, Germany
Cell Microbiol 6:377-90. 2004..We suggest that Yersinia enterocolitica might use two independent mechanisms to inhibit macrophage inflammatory responses at the transcriptional level... - Two distinct coagulase-dependent barriers protect Staphylococcus aureus from neutrophils in a three dimensional in vitro infection modelChristoph Guggenberger
Max von Pettenkofer Institut, Ludwig Maximilians University of Munich LMU, Munich, Germany
PLoS Pathog 8:e1002434. 2012..aureus abscess formation by temporal dissection of bacterial growth and recruitment of immune cells. It can complement established animal infection models in the development of new treatment options...