Jurgen Heesemann

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi request reprint Yersinia's stratagem: targeting innate and adaptive immune defense
    Jurgen Heesemann
    Max von Pettenkofer Institut, Pettenkoferstrasse 9 a, D 80336 Muenchen, Germany
    Curr Opin Microbiol 9:55-61. 2006
  2. pmc Yersinia V-antigen exploits toll-like receptor 2 and CD14 for interleukin 10-mediated immunosuppression
    Andreas Sing
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat Munchen, Pettenkoferstrasse 9a, Germany
    J Exp Med 196:1017-24. 2002
  3. ncbi request reprint Contribution of toll-like receptors 2 and 4 in an oral Yersinia enterocolitica mouse infection model
    Andreas Sing
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat Munchen, Munchen, Germany
    Int J Med Microbiol 293:341-8. 2003
  4. ncbi request reprint Mechanisms of Yersinia enterocolitica evasion of the host innate immune response by V antigen
    Andreas Sing
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat Munchen, Pettenkoferstrasse 9a, 80336 Munchen, Germany
    Adv Exp Med Biol 529:165-7. 2003
  5. doi request reprint Dynamics of adaptive microevolution of hypermutable Pseudomonas aeruginosa during chronic pulmonary infection in patients with cystic fibrosis
    Christina Hoboth
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Germany
    J Infect Dis 200:118-30. 2009
  6. ncbi request reprint Role of strain differences on host resistance and the transcriptional response of macrophages to infection with Yersinia enterocolitica
    Katrin van Erp
    Department of Bacteriology, Max von Pettenkofer Institut, Munich, Germany
    Physiol Genomics 25:75-84. 2006
  7. doi request reprint Yersinia enterocolitica Yop mutants as oral live carrier vaccines
    Robert Leibiger
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universität Miinchen, Pettenkoferstr 9a, 80336 Munchen, Germany
    Vaccine 26:6664-70. 2008
  8. pmc A hypervariable N-terminal region of Yersinia LcrV determines Toll-like receptor 2-mediated IL-10 induction and mouse virulence
    Andreas Sing
    Lehrstuhl Bakteriologie, Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Pettenkoferstrasse 9a, 80336 Munich, Germany
    Proc Natl Acad Sci U S A 102:16049-54. 2005
  9. pmc The Yersinia enterocolitica type three secretion chaperone SycO is integrated into the Yop regulatory network and binds to the Yop secretion protein YscM1
    Svea Dittmann
    Max von Pettenkofer Institut, Lehrstuhl für Bakteriologie, Ludwig Maximilians Universitat Munchen, Munchen, Germany
    BMC Microbiol 7:67. 2007
  10. ncbi request reprint Yersinia outer protein P inhibits CD8 T cell priming in the mouse infection model
    Konrad Trulzsch
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat, Munchen, Germany
    J Immunol 174:4244-51. 2005

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Yersinia's stratagem: targeting innate and adaptive immune defense
    Jurgen Heesemann
    Max von Pettenkofer Institut, Pettenkoferstrasse 9 a, D 80336 Muenchen, Germany
    Curr Opin Microbiol 9:55-61. 2006
    ....
  2. pmc Yersinia V-antigen exploits toll-like receptor 2 and CD14 for interleukin 10-mediated immunosuppression
    Andreas Sing
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat Munchen, Pettenkoferstrasse 9a, Germany
    J Exp Med 196:1017-24. 2002
    ..We conclude that yersiniae might exploit host innate pattern recognition molecules and defense mechanisms to evade the host immune response...
  3. ncbi request reprint Contribution of toll-like receptors 2 and 4 in an oral Yersinia enterocolitica mouse infection model
    Andreas Sing
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat Munchen, Munchen, Germany
    Int J Med Microbiol 293:341-8. 2003
    ..enterocolitica infection than wild-type C3H mice. To our knowledge, this is the first report on a divergent influence of a TLR-deficiency on infection outcome in mice of different genetic backgrounds...
  4. ncbi request reprint Mechanisms of Yersinia enterocolitica evasion of the host innate immune response by V antigen
    Andreas Sing
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat Munchen, Pettenkoferstrasse 9a, 80336 Munchen, Germany
    Adv Exp Med Biol 529:165-7. 2003
  5. doi request reprint Dynamics of adaptive microevolution of hypermutable Pseudomonas aeruginosa during chronic pulmonary infection in patients with cystic fibrosis
    Christina Hoboth
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Germany
    J Infect Dis 200:118-30. 2009
    ..In patients with cystic fibrosis (CF), the emergence of hypermutable Pseudomonas aeruginosa drives the selection of P. aeruginosa variants that are efficiently adapted to the inflamed lungs of these patients...
  6. ncbi request reprint Role of strain differences on host resistance and the transcriptional response of macrophages to infection with Yersinia enterocolitica
    Katrin van Erp
    Department of Bacteriology, Max von Pettenkofer Institut, Munich, Germany
    Physiol Genomics 25:75-84. 2006
    ..These data show that host resistance factors modulate a surprisingly small, but identifiable and functionally significant, portion of the macrophage transcriptome in response to Yersinia infection...
  7. doi request reprint Yersinia enterocolitica Yop mutants as oral live carrier vaccines
    Robert Leibiger
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universität Miinchen, Pettenkoferstr 9a, 80336 Munchen, Germany
    Vaccine 26:6664-70. 2008
    ..The success in designing a Yersinia oral vaccine carrier is therefore dependent to a great extent on the subtle balance between immunogenicity and attenuation...
  8. pmc A hypervariable N-terminal region of Yersinia LcrV determines Toll-like receptor 2-mediated IL-10 induction and mouse virulence
    Andreas Sing
    Lehrstuhl Bakteriologie, Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Pettenkoferstrasse 9a, 80336 Munich, Germany
    Proc Natl Acad Sci U S A 102:16049-54. 2005
    ..LcrV is a defined bacterial virulence factor shown to target the TLR system for evasion of the host's immune response...
  9. pmc The Yersinia enterocolitica type three secretion chaperone SycO is integrated into the Yop regulatory network and binds to the Yop secretion protein YscM1
    Svea Dittmann
    Max von Pettenkofer Institut, Lehrstuhl für Bakteriologie, Ludwig Maximilians Universitat Munchen, Munchen, Germany
    BMC Microbiol 7:67. 2007
    ..The effectors YopO and YopP are encoded on an operon together with SycO, the chaperone of YopO. The characterization of SycO is the focus of this study...
  10. ncbi request reprint Yersinia outer protein P inhibits CD8 T cell priming in the mouse infection model
    Konrad Trulzsch
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat, Munchen, Germany
    J Immunol 174:4244-51. 2005
    ..Using this approach we could further show that the listeriolysin O-specific CD8 T cells generated in vivo by the yopP mutant are functional and are able to protect mice against a lethal challenge with wild type Listeria...
  11. ncbi request reprint Horizontal transfer of Yersinia high-pathogenicity island by the conjugative RP4 attB target-presenting shuttle plasmid
    Uladzimir Antonenka
    Max von Pettenkofer Institut, Pettenkoferstr 9a, 80336 Munich, Germany
    Mol Microbiol 57:727-34. 2005
    ..Such 'trapping' of pathogenicity islands and subsequent shuffling to new hosts by a conjugative replicon carrying a suitable attB site could be applied to other functional integrative elements and explain wide dissemination of PAIs...
  12. pmc Contribution of trimeric autotransporter C-terminal domains of oligomeric coiled-coil adhesin (Oca) family members YadA, UspA1, EibA, and Hia to translocation of the YadA passenger domain and virulence of Yersinia enterocolitica
    Nikolaus Ackermann
    Max von Pettenkofer Institute for Hygiene and Medical Microbiology, Ludwig Maximilians University Munich, Pettenkoferstrasse 9a, 80336 Munich, Germany
    J Bacteriol 190:5031-43. 2008
    ....
  13. ncbi request reprint Transcriptional responses of murine macrophages to infection with Yersinia enterocolitica
    Reinhard Hoffmann
    Max von Pettenkofer Institut, Bacteriology Department, Pettenkoferstrasse 9a, 80336 Munich, Germany
    Cell Microbiol 6:377-90. 2004
    ..We suggest that Yersinia enterocolitica might use two independent mechanisms to inhibit macrophage inflammatory responses at the transcriptional level...
  14. ncbi request reprint The Yersinia high-pathogenicity island (HPI): evolutionary and functional aspects
    Soren Schubert
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Lehrstuhl für Bakteriologie, Pettenkoferstr 9a, D 80336 MUnchen, Germany
    Int J Med Microbiol 294:83-94. 2004
    ..A model of conjugative transfer for the dissemination of HPIs is proposed in which the excised HPI is mobilized to a new recipient either trapped by a transmissive asn tDNA-carrying plasmid or autonomously as an ICE named ICEEcl...
  15. ncbi request reprint Expression of Pseudomonas aeruginosa exoS is controlled by quorum sensing and RpoS
    Michael Hogardt
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians University Munich, Pettenkoferstrasse 9a, D 80336 Munich, Germany
    Microbiology 150:843-51. 2004
    ..Moreover, these data suggest that the exoenzyme S regulon may be downregulated in P. aeruginosa biofilms...
  16. ncbi request reprint Yersinia enterocolitica type III secretion chaperone SycD: recombinant expression, purification and characterization of a homodimer
    Annika Schmid
    Max von Pettenkofer Institut, Lehrstuhl für Bakteriologie, Ludwig Maximilians Universitat Munchen, Pettenkoferstr 9a, D 80336 MUnchen, Germany
    Protein Expr Purif 49:176-82. 2006
    ..To prove functionality of purified SycD previously suggested interactions of SycD with Yop secretion protein M2 (YscM2), and low calcium response protein V (LcrV), respectively, were reinvestigated...
  17. ncbi request reprint Yersinia enterocolitica evasion of the host innate immune response by V antigen-induced IL-10 production of macrophages is abrogated in IL-10-deficient mice
    Andreas Sing
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Pettenkoferstrasse 9a, 80336 Munich, Germany
    J Immunol 168:1315-21. 2002
    ....
  18. ncbi request reprint Characterization of YopT effects on Rho GTPases in Yersinia enterocolitica-infected cells
    Martin Aepfelbacher
    Max von Pettenkofer Institut für Medizinische Mikrobiologie, Ludwig Maximilians Universitat, Pettenkoferstrasse 9a, 80336 Munich, Germany
    J Biol Chem 278:33217-23. 2003
    ..These findings indicate that bacterially translocated YopT acts on membrane-bound and GDI-complexed RhoA but not Rac or CDC42, and this is sufficient for disruption of macrophage immune functions...
  19. pmc Transfer of the core region genes of the Yersinia enterocolitica WA-C serotype O:8 high-pathogenicity island to Y. enterocolitica MRS40, a strain with low levels of pathogenicity, confers a yersiniabactin biosynthesis phenotype and enhanced mouse virulenc
    Cosima Pelludat
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, 80336 Munich, Germany
    Infect Immun 70:1832-41. 2002
    ..Thus, the core genes of Yen-HPI are sufficient to confer a positive CAS phenotype and mouse virulence to Y. enterocolitica MRS40, BG 2, but are insufficient to confer this phenotype to Y. enterocolitica NF-O, BG 1A...
  20. ncbi request reprint Yersinia enterocolitica YopQ: strain-dependent cytosolic accumulation and post-translational secretion
    Janja Trcek
    Max von Pettenkofer Institut, Pettenkoferstrasse 9a, D 80336 Munich, Germany
    Microbiology 148:1457-65. 2002
    ..Moreover, post-translational secretion of YopQ could be demonstrated. These findings do not support the mRNA signal hypothesis for co-translational secretion...
  21. ncbi request reprint Yersinia enterocolitica inactivates NK cells
    Isabel Koch
    Ludwig Maximilians University, Max von Pettenkofer Institut, Department of Bacteriology, 80336 Munich, Germany
    Int J Med Microbiol 303:433-42. 2013
    ..Thus, we present the first report of a bacterial pathogen inactivating NK cells, and report interaction with Tyk2-STAT4 signaling as a novel function of YopP. ..
  22. doi request reprint Farnesol misplaces tip-localized Rho proteins and inhibits cell wall integrity signalling in Aspergillus fumigatus
    Karl Dichtl
    Max von Pettenkofer Institut, Ludwig Maximilians Universitat, Munich, Germany
    Mol Microbiol 76:1191-204. 2010
    ..After farnesol treatment this localization is rapidly lost, which is accompanied by swelling of the hyphal tips. Parallel displacement of tropomyosin from the tips suggests a concomitant disorganization of the apical actin cytoskeleton...
  23. pmc The two-component sensor kinase TcsC and its role in stress resistance of the human-pathogenic mold Aspergillus fumigatus
    Allison McCormick
    Max von Pettenkofer Institut, Ludwig Maximilians University, Munich, Germany
    PLoS ONE 7:e38262. 2012
    ..Although TcsC plays a role in the adaptation of A. fumigatus to hypoxia, it seems to be dispensable for virulence...
  24. pmc Bacterial toxins induce sustained mRNA expression of the silencing transcription factor klf2 via inactivation of RhoA and Rhophilin 1
    Kristina Dach
    Department of Bacteriology, Max von Pettenkofer Institut, Pettenkoferstr 9a, 80336 Munich, Germany
    Infect Immun 77:5583-92. 2009
    ..Thus, bacteria exploit the RhoA-rhophilin signaling cascade to mediate sustained expression of the immunosuppressive transcription factor klf2...
  25. ncbi request reprint The Yersinia enterocolitica type 3 secretion system (T3SS) as toolbox for studying the cell biological effects of bacterial Rho GTPase modulating T3SS effector proteins
    Stefan Wolke
    Max von Pettenkofer Institut, LMU Munich, Pettenkofer Straße 9A, 80336 Munich, Germany
    Cell Microbiol 13:1339-57. 2011
    ..In summary, the Yersinia toolbox is suitable to study cellular effects of effector proteins of diverse bacterial species separately or in combination in the context of bacterial T3SS-mediated injection...
  26. pmc Cross-talk between type three secretion system and metabolism in Yersinia
    Annika Schmid
    Department of Bacteriology, Max von Pettenkofer Institute for Hygiene and Medical Microbiology, Pettenkoferstrasse 9a, D 80336 Munich, Germany
    J Biol Chem 284:12165-77. 2009
    ..enterocolitica. We propose a "load-and-shoot cycle" model to account for the cross-talk between T3SS and metabolism in pathogenic yersiniae...
  27. pmc Yersinia enterocolitica type III secretion: evidence for the ability to transport proteins that are folded prior to secretion
    Gottfried Wilharm
    Max von Pettenkofer Institut, Pettenkoferstr, 9a, D 80336 MUnchen, Germany
    BMC Microbiol 4:27. 2004
    ..It was suggested that folding is prevented either by co-translational secretion or by the assistance of specific Yop chaperones (called Sycs)...
  28. ncbi request reprint Sequence variability and functional analysis of MutS of hypermutable Pseudomonas aeruginosa cystic fibrosis isolates
    Michael Hogardt
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat, Pettenkoferstrasse 9a, D 80336 MUnchen, Germany
    Int J Med Microbiol 296:313-20. 2006
    ..This work supports the hypothesis that the respiratory tract of CF patients represents an environment that favors the selection of highly adaptive mutator phenotypes...
  29. ncbi request reprint Uncovering genomic differences in human pathogenic Yersinia enterocolitica
    Andrey Golubov
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Pettenkofer Str 9a, 80336 Munich, Germany
    FEMS Immunol Med Microbiol 38:107-11. 2003
    ..Mapped out genomic differences may be applied in identification and development of novel therapeutic strategies for the treatment of enteropathogenic Yersinia...
  30. ncbi request reprint Yersinia enterocolitica type III secretion chaperone SycH. Recombinant expression, purification, characterisation, and crystallisation
    Wibke Neumayer
    Max von Pettenkofer Institut, Lehrstuhl für Bakteriologie, Ludwig Maximilians Universitat Munchen, Pettenkoferstr 9a, D 80336 Munich, Germany
    Protein Expr Purif 35:237-47. 2004
    ..In addition, we found that YopH was enzymatically active in the presence of SycH. This implies that the function of the secretion chaperone SycH is not to keep YopH in a globally unfolded state prior to secretion...
  31. ncbi request reprint Characterisation of the CipC-like protein AFUA_5G09330 of the opportunistic human pathogenic mould Aspergillus fumigatus
    Bettina Bauer
    Max von Pettenkofer Institut, Ludwig Maximilians Universitat, Munich, Germany
    Mycoses 53:296-304. 2010
    ..fumigatus during infection. Further studies are required to define the biological function of this hyphae-specific protein and its potential relevance for the pathogenicity of A. fumigatus...
  32. ncbi request reprint Yersinia as oral live carrier vaccine: influence of Yersinia outer proteins (Yops) on the T-cell response
    Konrad Trulzsch
    Max von Pettenkofer Institut, LMU Munchen, Pettenkoferstr 9a, D 80336 MUnchen, Germany
    Int J Med Microbiol 298:59-67. 2008
    ....
  33. pmc Yersinia enterocolitica infection of mice reveals clonal invasion and abscess formation
    Mark F Oellerich
    Max von Pettenkofer Institute for Hygiene and Medical Microbiology, Ludwig Maximillians University, Pettenkoferstrasse 9a, 80336 Munich, Germany
    Infect Immun 75:3802-11. 2007
    ..Furthermore, we show that the host severely restricts sequential microcolony formation in previously infected Peyer's patches...
  34. ncbi request reprint On the role of specific chaperones, the specific ATPase, and the proton motive force in type III secretion
    Gottfried Wilharm
    Max von Pettenkofer Institut, Lehrstuhl für Bakteriologie, Ludwig Maximilians Universitat Munchen, Pettenkoferstrasse 9a, D 80336 Munich, Germany
    Int J Med Microbiol 297:27-36. 2007
    ..Here, we focus on the role of specific T3SS chaperones, the specific ATPase, and the proton motive force in type III secretion...
  35. pmc Yersinia enterocolitica type III secretion depends on the proton motive force but not on the flagellar motor components MotA and MotB
    Gottfried Wilharm
    Bakteriologie, Max von Pettenkofer Institut, Pettenkoferstrasse 9a, D 80336 Munich, Germany
    Infect Immun 72:4004-9. 2004
    ..Thus, the hypothesis that the Ysc TTSS might adopt flagellar motor components was not confirmed. The finding that, in addition to consumption of ATP, Ysc TTSS requires the proton motive force is discussed...
  36. ncbi request reprint A novel integrative and conjugative element (ICE) of Escherichia coli: the putative progenitor of the Yersinia high-pathogenicity island
    Soren Schubert
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Lehrstuhl für Bakteriologie, Pettenkoferstr 9a, 80336 Munich, Germany
    Mol Microbiol 51:837-48. 2004
    ..It may represent the progenitor of the HPI found in Y. pestis and E. coli, revealing a missing link in the horizontal transfer of an element that contributes to microbial pathogenicity upon acquisition...
  37. ncbi request reprint Stage-specific adaptation of hypermutable Pseudomonas aeruginosa isolates during chronic pulmonary infection in patients with cystic fibrosis
    Michael Hogardt
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat, Munich, Germany
    J Infect Dis 195:70-80. 2007
    ..In cystic fibrosis (CF), such mutator strains may lead to the rapid selection of survivors that are specifically adapted to the hostile environment of the inflamed CF lung...
  38. pmc Characterization of an iroBCDEN gene cluster on a transmissible plasmid of uropathogenic Escherichia coli: evidence for horizontal transfer of a chromosomal virulence factor
    Liisa Johanna Sorsa
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, 80336 Munich, Germany
    Infect Immun 71:3285-93. 2003
    ....
  39. doi request reprint Probing the cellular effects of bacterial effector proteins with the Yersinia toolbox
    Stefan Wolke
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, LMU Munich, Pettenkofer Strasse 9a, 80336 Munich, Germany
    Future Microbiol 7:449-56. 2012
    ....
  40. ncbi request reprint Recombinant Yersinia enterocolitica YscM1 and YscM2: homodimer formation and susceptibility to thrombin cleavage
    Gottfried Wilharm
    Department of Bacteriology, Max von Pettenkofer Institut, Pettenkoferstr 9a, Munich D 80336, Germany
    Protein Expr Purif 31:167-72. 2003
    ..The YscM1 and YscM2 homodimers could be dissociated at high ionic strength, indicating that salt bridges essentially contribute to the dimerization. We further demonstrated that YscM1 and YscM2 are susceptible to thrombin cleavage...
  41. pmc Attenuated Yersinia pseudotuberculosis carrier vaccine for simultaneous antigen-specific CD4 and CD8 T-cell induction
    Holger Rüssmann
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat Munchen, 80336 Munich, Germany
    Infect Immun 71:3463-72. 2003
    ..For the first time, it is shown that cytosolic antigen display mediated by an extracellular bacterial carrier vaccine results in simultaneous CD4 and CD8 T-cell priming, conferring protection against an intracellular pathogen...
  42. pmc Improvement of reporter activity by IRES-mediated polycistronic reporter system
    Hicham Bouabe
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat, 80336 Munich, Germany
    Nucleic Acids Res 36:e28. 2008
    ..Thus, endogenous gene expression and regulation, especially those controlled by weak promoters, can be analyzed with our IRES-dependent polycistronic reporter gene expression system...
  43. doi request reprint AfMkk2 is required for cell wall integrity signaling, adhesion, and full virulence of the human pathogen Aspergillus fumigatus
    Franziska Dirr
    Max von Pettenkofer Institut, Ludwig Maximilians Universitat, Pettenkoferstraße 9a, 80336 Munich, Germany
    Int J Med Microbiol 300:496-502. 2010
    ..And in agreement with its sensitivity to moderate temperatures, it is less virulent in a murine infection model. Our data underline the importance of mkk2 for the fitness, but also for the pathogenicity of A. fumigatus...
  44. pmc Yersinia high-pathogenicity island contributes to virulence in Escherichia coli causing extraintestinal infections
    Soren Schubert
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, 80336 Munich, Germany
    Infect Immun 70:5335-7. 2002
    ..coli. Moreover, using a mouse infection model, we show for the first time that the HPI contributes to the virulence of ExPEC...
  45. ncbi request reprint Reactive arthritis associated with prolonged cryptosporidial infection
    Andreas Sing
    Max von Pettenkofer Institut für Hygiene und Medizinische Mikrobiologie der LMU, Pettenkoferstrasse 9a, Munich 80336, Germany
    J Infect 47:181-4. 2003
    ..Symptoms resolved spontaneously after 20 months in parallel with stool samples negative for cryptosporidia...
  46. ncbi request reprint Pitfalls of polymyxin antimicrobial susceptibility testing of Pseudomonas aeruginosa isolated from cystic fibrosis patients
    Michael Hogardt
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, National Consulting Laboratory Southern Germany on Cystic Fibrosis Bacteriology, Ludwig Maximilians University Munich, Germany
    J Antimicrob Chemother 54:1057-61. 2004
    ....
  47. ncbi request reprint Prospective study on nontuberculous mycobacteria in patients with and without cystic fibrosis
    Lorenz Leitritz
    Max von Pettenkofer Institut, Ludwig Maximilians Universitat Munchen, Pettenkoferstrasse 9a, 80336 Munchen, Germany
    Med Microbiol Immunol 193:209-17. 2004
    ..Treated CF patients showed favorable clinical outcomes, as opposed to untreated patients. We propose a modified definition for diagnosis and hence treatment of NTM pulmonary infection in CF patients...
  48. pmc Two distinct coagulase-dependent barriers protect Staphylococcus aureus from neutrophils in a three dimensional in vitro infection model
    Christoph Guggenberger
    Max von Pettenkofer Institut, Ludwig Maximilians University of Munich LMU, Munich, Germany
    PLoS Pathog 8:e1002434. 2012
    ..aureus abscess formation by temporal dissection of bacterial growth and recruitment of immune cells. It can complement established animal infection models in the development of new treatment options...